LOCUS       c00045_gnlPro..        14821 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJLEINMB_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:11:30
            Original ID  :: gnl|Prokka|KJLEINMB_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14821
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14821
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1572:4821]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1573..4821
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..14821
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14821
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             194..1570
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_1"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.1e-14, bitscore:
                     43.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 2.1e-121,
                     bitscore: 395.5, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VPGHKRGRGNPELAQLLGEKCVGLDVNSMKPLDNLCHPVSVIREA
                     EELAADAFGAAHAFLMVGGTTSAVQSMILSVCKAGDKIILPRNVHKSAINALVLCGAIP
                     VYVNPEVNAQLGISLGMEVSQVEKAMDENPDAVAVLVNNPTYYGICSDLRTIVKKAHAR
                     GMKVLADEAHGTHLYFGRNLPVSGMAAGADMAAVSMHKSGGSLTQSSLLLLNKSMNAEK
                     VRQIINLTQTTSASYLLLSSLDISRRNLALRGEESFEKVAGMAQYAREEINEIGGYYAY
                     GMDLINGTSVFDFDVTKLSIYTLGNGLAGIEVYDLLRDEYDIQIEFGDICNILAYISIG
                     DRLQDIERLVGALADIERLYKKDSTGMLSGEYIAPAVVASPQQAFYAEKESLPMEQAAG
                     RISGEFVMCYPPGIPILAPGEMVTQEIVEYILYARDKGCSMQGMEDPKVEHLQVLKGGI
                     "
     CDS             1573..2433
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_2"
                     /sec_met_domain="Spermine_synth (E-value: 5.6e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 8.3e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             2430..3710
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 6.9e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 3.3e-36,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             3700..4821
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.5e-15,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKNRLS"
     CDS             4769..5959
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_5"
                     /sec_met_domain="PAD_porph (E-value: 1.3e-128, bitscore:
                     418.9, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISDTKTLRTGFPDICRAIKEKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGTFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTQEDVDGFVFEEGEDEREAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             6060..6938
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_6"
                     /sec_met_domain="CN_hydrolase (E-value: 1.4e-56, bitscore:
                     181.9, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGIIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELSGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             7166..7627
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGKAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             7831..12528
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYDTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIRAEVTPNRLRSFVVQDILEDC
                     LTIEDASKISIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQFLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARSVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVAEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLNVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEVVFKTESTEPEKIVNTAKA
                     RGDISPEIAAQQEVYVKTKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGNGGSSYGNSGGYGSYQGGSMAGSS
                     KTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             12525..13412
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQ
                     MAGVKNREGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSKS
                     PAFEYGYKLSSPVYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAEPK"
     CDS             13604..14695
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_10"
                     /sec_met_domain="Peripla_BP_3 (E-value: 9.8e-34, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
ORIGIN
        1 aatatataga gaaataattg aatcattgtg ccggtttgag gcagtataca attgctgaat
       61 gatagaactg tatttgccgg tacatgacga caggaaaaga ggaacatgtc aaatggatta
      121 tgaaagacaa cagcatgcgc ccatatatga agcactggaa cgtttccgaa agaagagagt
      181 cgttcccttt gatgtgccgg gacataaaag aggaagagga aatccggagc ttgcacagtt
      241 gctgggagag aaatgtgtgg ggctggatgt taattctatg aagccactgg acaatctctg
      301 ccacccggtt tcggtgatca gagaagcgga ggagcttgca gcagatgctt ttggcgcagc
      361 gcatgcattc cttatggtag gaggaaccac atctgcagtg cagagcatga tcctgtctgt
      421 ctgcaaggca ggggataaga tcattctgcc gcgaaatgta cataaaagtg ccatcaatgc
      481 cctggtactg tgcggtgcaa ttccggttta tgtaaacccg gaggtgaatg cgcagctggg
      541 catttccctt ggcatggaag tcagtcaggt ggagaaggct atggatgaga atccggatgc
      601 ggtggcagtt cttgtaaata accctaccta ttatggaatc tgttcggatc tgcggactat
      661 cgtaaagaag gctcatgcaa gaggaatgaa ggtgctggca gatgaggctc atggaaccca
      721 tctttatttc ggcagaaacc ttcctgtgtc cggaatggcg gcaggtgctg acatggcggc
      781 agtttccatg cacaaatccg gcggaagtct gacacagagt tcgctgctgc ttttgaataa
      841 gagtatgaat gcagagaaag tgcgccagat catcaatttg actcagacca caagcgcttc
      901 ttatcttctg ttgtccagtc tggatatctc cagaagaaat ctggcactca ggggagagga
      961 atcctttgaa aaggttgcag ggatggcgca gtatgccaga gaggagatca atgagatcgg
     1021 cggttattat gcatatggta tggatctgat caatggaacc agtgtttttg attttgatgt
     1081 tacaaaactc tccatttata cactgggaaa tgggctggca ggtattgaag tttatgatct
     1141 tctcagagat gaatatgata ttcagatcga gtttggagat atctgtaata ttctggctta
     1201 catttccatt ggagacaggc ttcaggatat tgagagactg gtaggggcat tggctgatat
     1261 tgaacgtctg tataagaagg acagcacagg tatgctttcc ggggaatata tcgcacctgc
     1321 agtggtggcg tctccacagc aggcatttta tgcggagaaa gaatctctgc ccatggaaca
     1381 ggcggcaggc aggatcagcg gtgaatttgt tatgtgttat cctccgggaa tcccgattct
     1441 tgctcctgga gaaatggtga cacaggaaat tgtagaatac attctttatg caagagacaa
     1501 aggctgttcc atgcagggaa tggaggatcc gaaggtagaa catcttcagg tcctgaaagg
     1561 gggtatctga tcatggaatt atggtattcc gagttccata caggaaatgt aaagctttct
     1621 gtccggatta accgacagtt attttcaggg gaaagtgaat ttcagagaat cgatgtgttt
     1681 gagtctgaag aatttggaag atttgtggct ctggacggtg agatcgtatt ctctgataaa
     1741 gatgaattta tttatgatga aatggtcacg catgtgccaa tgacagtaca tcccaatgta
     1801 aaaaatgttc tgatcatcgg cggcggtgac ggtggagttg ccagagaact gatccattat
     1861 ccacagattg agagcattga tgtggtggaa tctgataaaa tgtttgtgga tgtatgtgcg
     1921 gagatgtttc cggatattgc ccagggactg aaggatgaga gagtcaacat ttattatgaa
     1981 gacggccttc ggttcctgcg gaataaaaag gccagatatg acctgatcat caatgattcc
     2041 acagatccgc tgggacatac agagggactt tttacaaagg aattctacgg aagctgttat
     2101 aaggctctca gagatgacgg aatcatggtt tatcagcatg gaagtccttt ttatgatgag
     2161 gatgaggtgg aatgcagaaa gatgcacaga aaggttttcc ggtcatttcc ggtgagcagg
     2221 gtttatcagg cacatatccc tacctgtccc tcgggatact ggctttttgg atttgcatca
     2281 aagaaatatc atccactgga agatttcagg ccggagaggt ttgataatct taatatagaa
     2341 acatggtatt atacaacaaa ccttcacaga ggagcattta tgcttccaaa atatgtagaa
     2401 gatttactgg aagaggagga aaacagttta tgagcagatt attggtaatc ggatgtggtg
     2461 gggtagcttc agtggcaatt cgcaaatgct gtcagaatag cgatgttttt acagagatta
     2521 tgatcgcaag caggacaaag gaaaaatgcg atgcactcaa agagaagatt gaaagtacaa
     2581 cgaagacaaa aattgagaca gcaaaggtag atgcggataa tgcagcagag gtcgcagaat
     2641 tgatcagagc ctataagccg gatgctgtcc tgaatgtggc acttccatat caggatctta
     2701 ccatcatgga tgcatgtctg gaagccggtg cggattatat tgatactgcc aattatgaag
     2761 cagaggatac agaagatccc acatggcgtg caatctacga aaagagatgt aaagaaaaag
     2821 gctttactgc atatttcgat tattcctggc agtgggctta tgatgagaaa tttaaggaag
     2881 caggactgac tgctcttctg ggaaccggtt ttgatccggg tgttaccagt gtattcagtg
     2941 cctatgccct gaagcattat tttgatgaaa tccataccat tgatattctg gactgtaacg
     3001 gcggtgatca tggatatcct tttgccacaa actttaaccc ggagatcaat cttcgagagg
     3061 tttccgcaaa tggttcctac tgggaagacg gacattgggt agaaacagag cctatggaat
     3121 ttaaatctgt ctacgatttt cctgaggtag gaaagaagga tatgtatctc cttcatcatg
     3181 aagagattga atcactggca aaaaatattc cgggagtaca gagaatccgt ttctttatga
     3241 cattcggaca gagctatctg acacatatga aatgtctgga aaatgtagga atgctttcca
     3301 ccgcacctgt ggaatttaat ggacaggaga tcgtgccgat ccagtttttg aaagctcttc
     3361 tgccggatcc tgcatctctg ggtccgagaa cagtgggtaa aacaaatatc ggctgtattt
     3421 tcacaggtgt taaggacgga aaagagaaaa gtatttatat ttataatgta tgtgatcatc
     3481 aggaatgcta taaagaggtg gaatcccaag caatctccta tacaacaggt gttccggcta
     3541 tgatcggttc catgatggta gtgaccggac agtggaagaa gccgggtgta tttaatgtgg
     3601 aagaatttga tccggatcca tatatggaag cactgaacaa atggggactt ccatggaaag
     3661 tctgcgaaga tcctgaactg gtaaaggtct ggaaagccaa tgaagattga tcaactgcaa
     3721 actccctgct atgtgatcga tgagaagaag atgagggaga atctggagat tttgaaaaaa
     3781 gtccaggagg ataccgggtg taagatcctt ctggcgcaga aagcgttttc cggctttgct
     3841 ctgtatccca tgatcggaaa atatctggca ggtaccactg ccagcggtct gtttgaggca
     3901 aggcttggat atgaagagat ggggaaagag aatcatgttt tttcccctgc ttaccgtaca
     3961 gaagatatag aagaactgga tcgtatctgt gaccatatta tctttaattc cacagcacag
     4021 ctgaagaaat ttaaagaagt gtgtaccgga gccagtctgg gactccgtat taatccggaa
     4081 tgctccactc agggggatca tgcgatctat gatccctgtg cgccgggttc caggctgggg
     4141 gttaccagag agaactttga cggggaatgt ctgaaatgga tcgacggact gcattttcat
     4201 acgctctgcg aacagaatgc ggatgacctg gagaaaacat tgcaggcggt agaggagaag
     4261 tttggagaat ttctgtctga ggtttcctgg ctgaatatgg gcggcggaca tcatattacc
     4321 agagaggatt atgatgtaaa gctcttggaa aaatgtattc agcatatgaa ggaaacctat
     4381 gatctggata tttatctgga gcccggggag gctgttgccc tgaatgccgg atatctggtg
     4441 acagaggtta tggacattgt ggaaaatgag atcagaacgc tgattttgga tgcttctgca
     4501 gcctgccata tgccggatgt gctggagatg ccctatcgtc cgcctcttaa ggacagcggg
     4561 gaagcagggg agaaggcata tacctaccgc ttatcttcct gcacctgcct ggcaggagat
     4621 gtaatcggag attattcctt tgacagagag atccggatcg gggacaagct gtattttatg
     4681 gatatggcga tttattctat ggtgaagaat aatacattta acggtatgcc gctgccggat
     4741 attgcggtta tgcatgagga cggagagtgt gaggttatca gacatttcgg atacgaagac
     4801 tttaagaacc ggctttcctg atatctgccg ggctatcaaa gaaaaggaga cagacatgga
     4861 agttacagag aagaacagaa caaaatatcg tatgcccgga gaatttgagc ctcatgaggg
     4921 atgtgtgatg atctggccgg aacgtcccgg ttcctggaat tatggggcaa gggaagcaca
     4981 gaaagcattt gtgaaagttg cagaggctat tggagagagc gaaaaggtgt atatgctggt
     5041 ttccaaagct cagatggaga atgcaaagaa tcagcttggg aatgtttccg gtgtgacttt
     5101 gctggaatgc gagacagatg acgcctgggc cagagatgtg ggagcaacca tggttctgga
     5161 tgagaaaggg gcggtctgtg gagttgactg gcagtttaat gcctggggag gtacctttga
     5221 cgggctttac cggaactggg aaaaggatga cagggtggct gcctttatct gcaggactct
     5281 cggttgtcca tgtctggatg ccagaccttt tgtgctggag ggcggttcca tccattctga
     5341 cggagagggg actctgattg ttacagaggc ctgtcttctg agtcagggac gtaatcctca
     5401 gatgagcagg gaacagatag aggaacagtt gaagtactgg ctcggtgtcc acaagattat
     5461 ctggcttcca tgtggaatct atcaggatga aaccaatgag catgtggata acgtgtgcgc
     5521 ttttgtaagg cccggagagg ttgtgcttgc atggacagag gatgagacag atccgcagta
     5581 tgccatgtct ctggctgatc tgaaggtgct ggaacaggaa acagatgcaa aaggcagaaa
     5641 atttaagatt cataagcttc cgattcctca gaaaccggtc tgccttaccc aggaagatgt
     5701 ggatggcttt gtgtttgaag agggagaaga cgaacgggaa gcaggagaac ggatggctgc
     5761 cagttatgtg aatttctata tttccaatgg aggaatcatc cttccacagt ttggggatga
     5821 aaatgacaaa agggcagtgg agattctgca gaagtgtttt cctgaaagaa ggatttatcc
     5881 cattgatgcc agagccatca ttgtcggcgg tggaaatatt cactgtatca cccagcagat
     5941 tcccggaaaa aatatctgac cctgatgcag aaaactttga gagtcatgtg tttgagggtt
     6001 atacctgaaa gttatgaaaa aacttactta tgtaaacagg agcaggagga acagacagga
     6061 tgagaaatgt aacagtggca gcagttcaga tgaaatgcag taaaagtgtg gagaaaaata
     6121 ttgcccatgc agaggaactg gtgcgtcagg cagcagcaaa gggagctgag attgttcttc
     6181 ttccggagct ttttgaacgg ccctatttct gccaggagcg cagatatgag tattatgaat
     6241 atgcgcagac tgcagaggaa aaccctgcag tgcgtcattt cagcagggta gcggcagagc
     6301 tggggattgt gatcccggtc agcttttatg aaaaagaggt caataatacc tataacagcg
     6361 ttgcggttct ggatgcagat gggaagaatc tcggcgttta ccggaaaaca catattccgg
     6421 atgaccatta ttatcaggaa aaattctatt tcacaccggg agataccggc tttaaggttt
     6481 ttgataccag atttggaatc attggagttg gaatctgctg ggatcagtgg ttcccggaaa
     6541 cggcaagatg tatggcactg cagggagcag agcttctctt ttatcccact gccatcggca
     6601 gtgaacccat cctggaatgt gacagcatgg aacactggag aagatgtatg cagggacacg
     6661 ctgcctccaa cctgatccct gtgatcgctg ccaacagaat cggtgaggaa acagtagagc
     6721 catgtccgga aaacggaatg cagaaatctg ctcttaattt ttacggctct tcttttatca
     6781 cagacaacac aggtgctctc tgtgcagaac tgtccggagg ggaagagggg gtgcttgtaa
     6841 gcacttttga cctggatgca ttaaaggcag acagactgaa ctggggactt ttcagagacc
     6901 gcagaccgga aatgtatgca aaaattgtcg ggaaatgaca tacaagccaa aattccattg
     6961 ccgcaggcaa tctggaatga attttggctc agttactgag aacggagtga acagtaactg
     7021 agtttataag aatttcataa aaagtttatg attatattag ttgctacctg cggtatatat
     7081 ggtaaaataa gagtacgaac gttactgata acggagagag cagtagagtt ttgatatgta
     7141 tttctggcaa aatggagtgt agaagatgaa cagaaaagaa tttttggaaa tcctgagaag
     7201 ccagcttgcc gggcagatgc aggagggcaa agcagcagca catatcaggt attatgaaga
     7261 ttatatacag tctcaggtac gtggcggacg ttcagagcag gaagtactgc aggaactggg
     7321 agacccgcat ctgatagcaa aaactctgat tgatacagat gatggaagta cacaggaaga
     7381 ttacggagag tattcttctt acggaagcag ttatggcaat gagacagagc ttcctcatca
     7441 gcaggagaaa agatggaaaa aagtaatcga tctttctacc tggcatggca aggctgttgt
     7501 tattgcagcg gcggctgtta taattgtttt actgatactg ataatcggag ttgcgattcc
     7561 gttttttatt attcttgcaa ttattcttta ttttctttca tggctgaaga aaagaaatga
     7621 tcaatgaaaa tctgtgcagg gtttcagaaa aggaaccctg cgcagaatct taaaaatctt
     7681 aagtgtaaac gttcttgttt cacgatatta attccccttg aatatttata atcatacaat
     7741 ctcaacttat ttctattctt taatcctgcc aggtgcaggg aaaaatccca cattcatttt
     7801 tatatttttt gttcggaaag gagacggaaa atgaaacaca atttcaaact gaaagaacgc
     7861 cttggagctt tgctgcttgc aatgcttttt attctgcagg caattctggg gcttgtgcct
     7921 gtctgcgtaa ctcaggcggc accgttaact gtagaaacat gggacagtga caaggtggta
     7981 gattatggtt atcgctttaa catgaagttt cagcccggaa ttaccacata tgaatctttt
     8041 gggtgtgata atctggacag ggaagctttt tcagacaatg gaaaaagcga acgtgacaca
     8101 gagtgcgttc gtgtaggagc ggactataaa gccggaagcg cagggatgcg ttataacaat
     8161 gtaggaaaag atggaaatgg aaatattgtt gatgtcagac tcattcttgt gggagtagag
     8221 aatgcagaac cccgttatga tttgcgcact gcagaatcga ttgttcagaa taaaggcgga
     8281 gctacgtttg catggaaaga taatgaagct tatccaatgg ttggcttttc caaaaacagt
     8341 atcggtgtat ttatttattc tgtaggatac gcaaaggtta agtttcagtt tctgaagcat
     8401 ggaacagaag aaacactgcc gatcagtggc catggaacca tacgtgatat tgatgcggga
     8461 cagggagtcc gtattccgtc agacagcagt ctggataatg catatgttct gaaaaacaat
     8521 gattatctga cggtagatgg aaattctgta agctcacccc tgggttccgt tgagccggat
     8581 gatccgagag gatggctgaa tcttttttat gatacagata attttacggt agaattctgt
     8641 catcagttca gactggataa atgggataaa agtcgtgaag atgccattgc aaaagccggt
     8701 tctcaggaaa gatgggcaga gattacaaga aataaatatc tggatccatc aggcaacagt
     8761 tattgtccga actttaaagg acagaaatac tgcaaagcat atgcatattt tgattttaca
     8821 tcctattgtt tcggtgatgt tgagatgaaa aaagcgcctg agaaacgtgt gggagaggca
     8881 aactgtacat gggaacaggc agctgccgca tcaaaagaaa aaccttttgg cattcgtcag
     8941 ggacaggaat ttcagtatat gatccgggcg gaggtgacac ccaatagact gagatccttt
     9001 gtggtacagg atatacttga ggattgtctt actatagagg atgcatcaaa aatcagtatt
     9061 gtgaatgatg cagggcagac agtgacagac tggtttgatg ttgctgttga aggacagaaa
     9121 gtgacctgca gggccaaagc agagagcctt caggatgaag catttacaga taatcagact
     9181 tacacattta ctttaaaagt acgccagaga ccggaatcag aaattaacat ttcaaaatac
     9241 cttgcagagg atgggtacag tattcttgta ccaaaccatg catccatgag ttatgaacgt
     9301 acaaacggaa gcggagatac aatggatacg gaaacagtgt gggtaaaggg tgtgattcca
     9361 ccggaactgg aagtaaagaa aaatacttct cagtatgaat ggaaaacggg agatatcata
     9421 gattatgagg ttctggtttc tcagacaaaa caggatgtaa aagcagtaaa tgttgttatt
     9481 acagatgagc ttccatcatg tctgcagttt ctggaagggc agtatgctgt agagacaagt
     9541 cagggaggcg agaactgtac gcttaccgga cagggagaaa atggatggaa agcagagtgt
     9601 ccgtccctga agtatgggga gacgatcaca atccgtttta aatgtcaggc atctgcggat
     9661 tccaatggac aggaatggga aaatattgtg actgcaacag cggataatct gatcaatcct
     9721 gagacaggag aacaggaatc cagaaaggat atggcagaag tatggccgaa cagtccacag
     9781 cttgaaattg ataaaacagc agacaaatat gaatggcagg caggagagca ggtagcttac
     9841 cggatcgtgg tgaataatgt aacggcagga acaattgcaa aagatgtaac tattactgat
     9901 attggtctgc cgcagggact ggttctggca ggtggtgcac agagcatgga agtactggga
     9961 gttcagcaac aggtaaacta tcccgtaccg gataagaaaa caggacaggc atatgaagcg
    10021 agatctgtgg attctcagtt gaatgcagat gagaacggat tttcctttta ttgttcttat
    10081 gtgccataca gtcagcctgt aacgattatt ttccattgta tcgcacagga agaggcaaat
    10141 ggacacgaaa gcgtaaatgc agcaactgta aaagctgcta atacagatga gagatctgat
    10201 gatgcagaag tatatgtaaa ttcaggagaa ttctggattg agaaatctgc agatcattat
    10261 gaatggcagg tcggagaaca ggtacagtac aatgtggtgg tggagaataa aaaagcaggt
    10321 acagtggccc ggaacgtaac tgtctgggat accggtatgc cggcaggact tgcgctttca
    10381 tcggcagagg atgtatcggt aagcggaatc ccacagaata ttacgcagct gacagcaggg
    10441 accaaagatg ttttgaacca gctcaatccg gaattttata atgagacatc agagaaaccg
    10501 gtgaattatg aatttcttca ggagggaagc ggatggagac tgaacatttc agatcttccg
    10561 gcaaatactc cggttatgat ttctttcctt tgcacagttg cggaagcggc aaatggaatg
    10621 gaaagcatta atgttgccaa tgtgcaggcg cagaatgccc ctgtttcaca ggatgacgca
    10681 gaagtgtatg taaatacagc agttctttct attgagaaaa gttttcagaa tccatatctg
    10741 gcagccgggg atggacgtgc ggaaaatgaa tttcgggtag gagaacaggt gaattatcag
    10801 gttacggtta ataatcttca gaagggatct atcgcaagaa atcttgtgat cagtgatctt
    10861 tcccttcctg aagggctggc tctggacgga gctgaagatg ctgttactgt aagcggtgtt
    10921 ccggctgtta ttcagaatcc ggtggcagga actgatgatg caggaaatca gctgaatccg
    10981 gaaaattata aagaaacagt ggaaaaaccg gtcagctgtc aggttacacg tcagggaacc
    11041 ggatggatcg tgacgatttc agatcttccg tatcagacac ctgtgactgt taatttccgc
    11101 tgtactgcgc aggaaagcgt aaatgggatg gagattgtaa atacagcaca ggcgtatgca
    11161 gataatgcac agaaagtaaa ggactcctca aaaatctggg tgaactcgcc tgttcttaac
    11221 gtagagaaga cgacggacaa accattttac aaatatggtg atattattac ataccgcatt
    11281 gtcctgacac aggagcagac cggatgtgtg gcgcgtaatg ttactctgca ggatgtgatc
    11341 gatactcagg gagtacgtct tctgaaggat tcggtgattc tgatggatga gaaaggaaat
    11401 gtggcagatg ctgatgtaca gatcaatgat gataatactt tcctgatgtc aacaggcagg
    11461 acactggtca gggacagcag atatagtatc tgcgataatg ataaaggcgg tctttttgag
    11521 caggtaatgt ataatcctct ggactgtcag gaacagaaaa gtatgatcgt ggaatatcag
    11581 gcagcagtga ttgatgcagc cctggcagga cagaaagtgc acaatactgc agttgcagac
    11641 agcagtgaaa agatacctgc aaccggggaa acagagacag aggtacacag tccgattctg
    11701 gaaattgtga aggaatcaga taagaaagag tatgcgtccg gtgagaaagg atactataag
    11761 ctgacagtaa gacaactgcg tgaggatgtc acagatcaga atattgttat cgaagataaa
    11821 ctggaaaccc aaggggcttc tattgtaaaa gacagcattt ttgtgaagaa aaacggcata
    11881 gagctgaaag atgccaaaat agaggcagat gatacaggat ttgtaattca gacaggagca
    11941 tcgttgtcag atatggataa aattgaagtc tgctatgaag tggtatttaa aacagaaagc
    12001 acagagcctg aaaaaattgt aaacacagcg aaagcaagag gagatatttc accggaaatt
    12061 gcggcgcagc aggaggtata tgtgaaaaca aaagcagaac ccactgccac accaacaccg
    12121 tctgcaacac cgaaaccaac agaaacacca aagccgacag agacaccaaa acctacagaa
    12181 gtaccgaaac cgacggagca gccaaaagcc acaccaacac catctgtacc gggaacctgc
    12241 ccgaaaatga ctcctgtacc gacgaaagca ccgttggcat cttacaatgg tggaaataat
    12301 ggaggcacaa cttccggaaa cggaggcagc agttacggaa attcgggtgg atacggaagc
    12361 tatcagggtg gttccatggc aggaagttct aaaacaggag atgtcagacc gtttaaaatg
    12421 atggctgttc ttggacttat cggaatggga ctgctgacag gaggtgtggt gatctacaga
    12481 agaactgttt ccgggaaaag aaatataaag ggtatgccgc ggaaatgaaa aaactcagaa
    12541 catttgcagt aagtatgatc atagcagcaa ttgggcttct tatatattgt gccggtttct
    12601 atataaaaag ttatgaacag aatcttgcag caaggcagga atatgcagag ctttcccaaa
    12661 tggcaggggt gaagaacaga gaaggtgccg gattattggc agacggcaaa aaaactgatg
    12721 aagacagcag tacaaaaaac agtgaaaaaa aacgcaggaa aaaacagaga agatcttctg
    12781 aatcaaaaaa caaaaactgt acagatgaaa tcagggaatc cttcgggatt tcctgggaaa
    12841 atttaagaaa gatcaactct cagacagttg cctggattac tgtcccggga gccgatattt
    12901 cttatcctgt agttcaggcg gcagatgatg aatattacct gaaacataat ttcagaggag
    12961 aggaagatct gtttggatgt atttttctgg aacatgacat aaaaaagaat tttacagatt
    13021 cccacagtat tctttacggg cataatatag aaggtaatat gatgtttgca aatctgaacc
    13081 gttatgaaca gcctgaattt ctaaaaaaat gtcctgaaat tgagatcaca acaccaaaaa
    13141 gaaagtttct gtacaaaatt ttttctgtgg aacaggcatc ttccaaaagc ccggcatttg
    13201 aatatggata caagttatcc agtcctgtat acaggagaca attatctata ttgaaaaata
    13261 attccatgta tgacacagga gtagagcctg atgaaaggga gagaatggtg actctgatca
    13321 cctgtaattc acgtctggat aaagaaatac gtatggcggt acatgggatt tgccatgaat
    13381 gttatggtat agaaaaagct gagccgaagt gatgttgaaa tcaatcggat attggtaact
    13441 ttcgtaaagg atgaactgtt actgttcaca tatcactatc cctcgaggtg ttttggaaaa
    13501 aactaatgaa aaatctctcg atattttgta taatttgtgc ataaaaaaca acttgttcgt
    13561 acgtgcgtac aagttgtatc ctaaatacag gagggaagaa gacatgacag ataatggaaa
    13621 gccgaaatat ttctcactga tggaacagct cagaagtgat attatgtcag gagctatccg
    13681 accgggagag aagcttcctt cagaaaacga gctttcacag aaatattccc tgagtagaca
    13741 tacagttcgt aaagcactgg gaatcctgga gcaggacgga tatgtagagg catttcacgg
    13801 aagaggtact tattgctctg agaatatgcg ccatataaag aattcaaaga atattgcggt
    13861 agtgaccaca tatatttctg attatatttt tccgagactg atacagggaa tggataatgt
    13921 cctttcagaa agcggttaca gtattatcct gaaaaacaca gcaaacagca gacagaaaga
    13981 ggccagatgt ctggaggaac ttctgaagaa agatattgat ggactgatca ttgaaccaag
    14041 caaaagtgag atgatctgta aacacagaaa tctttatcag aatctggata aatttgaaat
    14101 tccgtatgtg tttattcagg gaatctattc agaaatgagg gataaacctc atattcttat
    14161 ggatgatgca cagggaggct atcttgtaac aaaatatctg ctggaactgg gacataaaaa
    14221 gatcaagggt ttctttaagg cagacgatat gcagggactg gagcgccaca agggatatgt
    14281 gaaggcctta caggagtcag ggattgccta tgatcctgat gatgttgtct ggtttcatac
    14341 agaggacagg aaagtaaaac ctgcactgat ggcaaaagaa atggtacaga gcggacagct
    14401 tccggatgga atcgtctgtt acaatgatca gattgctgtt caggttatgg aagaactgga
    14461 gaaaatggga gtcaggatac cggatgatat ttccattacc ggttatgaca attcactgta
    14521 tgctcagcga ggaagcggaa tcacaacgat agctcatccg caggaaaagc tgggagaaat
    14581 ggcagcagag cttatacttg agaagatcaa cggagttcct gaagaagaaa gtaaggttga
    14641 aagactgatt tatccggaac tgatcatacg gggatcatgc agaaaaatat tgtaaacaaa
    14701 tgaaataaat aaaaaataaa aataaatccg ggaggaattt tatcatgaaa acaggaagaa
    14761 actataagtt ctggttttgt acaggttcac aggatcttta cggagatgag tgcttaagaa
    14821 a
//
