LOCUS       c00033_gnlPro..        15977 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAGPJMLO_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:11:32
            Original ID  :: gnl|Prokka|DAGPJMLO_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 24889
            Orig. end    :: 40866
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15977
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[34889:40498]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15609
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15977
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15977
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1790..2320
                     /locus_tag="ctg33_17"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKIRLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             2574..3992
                     /locus_tag="ctg33_18"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANL
                     KMPFISKKDHGDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             4134..4847
                     /locus_tag="ctg33_19"
                     /transl_table=11
                     /translation="LLVLEERIVMKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYS
                     GSGISAISSVPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAF
                     SEFLDVNEAWINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEI
                     IKVKYSKIKVSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKH
                     FRFVNFTQHCSLHVQ"
     CDS             4983..5180
                     /locus_tag="ctg33_20"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             5174..5938
                     /locus_tag="ctg33_21"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             6279..7463
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.4; E-value: 1.6e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_22"
                     /sec_met_domain="MFS_1 (E-value: 7.9e-25, bitscore: 78.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             7479..7721
                     /locus_tag="ctg33_23"
                     /transl_table=11
                     /translation="MERLIFHIDVNSAFLSWESARRVSQGIPEKMWPLPVRNLLFLGKA
                     SEQKLLNQGIRTIGDLAREREANVQLWLGEKPEHR"
     CDS             complement(7793..8758)
                     /locus_tag="ctg33_24"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDARTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(9017..9652)
                     /locus_tag="ctg33_25"
                     /transl_table=11
                     /translation="MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(10001..10249)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_26"
                     /sec_met_domain="ALS_ss_C (E-value: 4.5e-23, bitscore:
                     72.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEILYIKVFNCSREDKAELFQIAETFKAKVIDYGKDSLLLEFVQ
                     TAIKNDAVVKLIKEEFHRIEVVRGGSVGIESISMMER"
     CDS             complement(10562..11275)
                     /locus_tag="ctg33_27"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             12038..13294
                     /locus_tag="ctg33_28"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGNPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             complement(13363..13872)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_29"
                     /sec_met_domain="ALS_ss_C (E-value: 7.1e-23, bitscore:
                     71.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSREDK
                     AELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(13891..15609)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_30"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-49, bitscore:
                     157.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDVLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFKEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             complement(15797..15976)
                     /locus_tag="ctg33_31"
                     /transl_table=11
                     /translation="RGNIFALGKQAQGVFYYIQNCGSCFTAFSAESAQRHSAPVSANTQ
                     LRNLFVWCAFAGVV"
ORIGIN
        1 tcagactatg gcatcggatg tttttccaaa agtgcatatg aatttgtaga ctggttaaag
       61 gaagcaggac agacttactg gcagattctg ccattgggac cgaccagcta tggagattct
      121 ccatatcagt ctttctctac atttgcaggt aatccatatt ttattgatct ggatacactt
      181 gtggaagaag gagttcttga taagaaagac tgcgagaaag ttaactgggg aaagaagcct
      241 gatgaggtag attatgaaaa aatctacaaa ggccgttatc ctcttctgag aaaagcatac
      301 gagaacagtg atatcagcaa gaatcctgac tatcagaaat tcgtagcaga gaacagctgg
      361 tggttgtcag attatgctct gtttatggca gtaaaagacc gtttcgaagg tgtagaatgg
      421 accaaatggg ctgaggatat cagactccgc tggaacaatg ccatggatta ttatcgtgaa
      481 gaactctatt ttgatattga attccagcag tatatgcagt ttaagttcta tgagcagtgg
      541 atgaaactga aatcctatgc aaattcaaaa ggaatccaga tcattggaga tattccgatt
      601 tatgttgcaa tggacagtgc tgatgcatgg gcgcatccgg agctgttcca gctggatcag
      661 gataatgtac cactggcagt agcaggatgc cctccggatg gattttctgc aaccggtcag
      721 ttatggggaa atccgttata tcgctgggat tatcacagaa atacaggata tcagtggtgg
      781 atttccagaa tgagttattg cttcagactg tatgatgttg tgcgaatcga tcatttccgt
      841 ggatttgatg aatatttctc tattccatac ggagataaag atgcaagagg cggacactgg
      901 gaaaagggtc ccggaattga tctgttccgt aagattgaac aggcgcttgg atggaagcag
      961 gttattgcag aggacttggg atatatgaca gattccgtac gtcatctggt atatgagagc
     1021 ggcttcccgg gaatgaaggt tctggaattt gcgtttgact ccagagattc cggatgtgcc
     1081 agtgattatc tgccacataa ctatccggag aactgcgtgg catatacagg aacccatgat
     1141 aatgaaacta tcgtgggatg gtggaggagc atcacagcag ctgagagaaa actggcgaga
     1201 gattatctgt gtgatcatgc aacaccggaa gaagaactgt ataaatgttt catcagtctg
     1261 atcatgcgca gtgctgcgcg cgtctgcgtt atcccaatgc aggactatat gggactggac
     1321 aacagattcc gaatgaataa accatctaca gttggtacga actggaagtg gagaatcaag
     1381 aagagagatc ttacaaagaa actccagaag gaaatctatg atgtgacact tcgttacgga
     1441 cgtaagaact gggattaaat acataatgaa ataattggaa taatgacagc gtttcggata
     1501 taaataatat tcggaacgct gtttttttaa ccgaatcaag cagttatttg gttaaaaaag
     1561 caacgaagtg gttggtttta tctgttttgt tttatccagt cagagttatt tgtcagaggg
     1621 agaaaaaaag gacagtttcg caagctcttt atttttgtat gaaaaagaaa acattgaaat
     1681 tgttttggcg ggcgtacaat tgaaaaagaa atgcattgat tttcgggcaa tgtctgataa
     1741 aatattaacc agaaaaagca aaagaacaga ttttcaggag ggaaaataaa tgaactataa
     1801 cagattagaa accagtctga tcgatgtgat caaagaggaa caggcgaagc ttggatatat
     1861 gaaggagaag attcgccttt attatccgct cagttccctg aatcatttct ttggcaatga
     1921 gacggatgct gcaggcatga tggagatttt aaaagatttt ccttcttata tagaagagaa
     1981 atttggtgaa gtagcagtat cacacagagg agatcgtttc tgcttcactg tttcggaaaa
     2041 agcttccgaa tatgtacata ataatatgaa agagaatgaa tttatcaagg cattgatcga
     2101 actggttggc agacatggat gtacgataga ggaaattaaa gaactgttcc attcttattc
     2161 agataaaatc attactgaac caatggataa cgaggagttt gatgtgatga tccgctttga
     2221 tgatggatca gatccttatt attattgttt taaagatgaa ggatgccata tcatttacca
     2281 cagatttctg ccggaagact atgcagattt tggattctga taagaatgag tgaaaaattt
     2341 tccaactgtc ggatcagcaa aaatatatgt gatatttgca acaaaagtat gttatttttt
     2401 tgtcaaatat caacaaaaat aagtcgaaat tctatattga cagatagtct caataatggt
     2461 aatttttatt tgatttaatg ttttcattta tagaaacagg taaaatttta ttacattatt
     2521 ttacaggaat aaaatagata aaattgagtt gacagtttgg agggaaagat taaatgagaa
     2581 aaaccaaaat tatctgtaca atgggaccgt ctactgataa gggcgatgtt atggagcagc
     2641 ttgtgagaga gggaatggac gtagcacgtt tcaacttctc acatggacct cacgatgagc
     2701 agagaggccg tatccagaaa ctgagagaac ttcgcaagaa atatgacaga cctgttgcag
     2761 cacttcttga tacaaaggga ccggagatca gacttggatg cttcaaggat ggcaaggttt
     2821 ctctggaaga aggacagata tttacattta caaataaaga tattgaagga actaatgagt
     2881 gcgtaagcat tacttataaa gagctttata aggatgtgca gccgggcgga catattctgg
     2941 ttgatgatgg actggtagac ctggaggttc aggacatcgc aggaaaggac attgtctgca
     3001 aggttattaa tgcaggtgtg attggcgaca ggaagggtgt caatgttccg ggtgcaaacc
     3061 tgaagatgcc attcatcagt aaaaaagacc atggtgatct tctcttcggt atccaggaag
     3121 gatttgattt cgttgcagca tcttttacac gtactgcaaa cgatatccgc gaagtaagaa
     3181 aaattctgaa agaaaacggc ggtgaagaga ttcagatcat tgcaaagatt gagaaccagc
     3241 agggcgttga caatatcgac gagattattg aagcagcaga tggcatcatg atcgccagag
     3301 gtgacatggg tgttgagatc ccgccggaat atgtacctgt tatccagcag aaaatcattc
     3361 agaaagttta cacagcagga aaaccggtta ttacagcaac acagatgctt gactccatga
     3421 tctctcatcc gagaccaacc cgtgcagagg ctacagacgt tgccaatgcg attttccagg
     3481 gaacaagtgc aactatgctt tcaggagaaa ccgcagccgg taaatatccg gtacaggcac
     3541 ttcagatgat gagccgtatt gcagaacata tggagcagaa tattgattac aatacaatct
     3601 ttaagaaaac agacagaaat gagaatccgg atattacaaa tgcaatcgca catgcaacct
     3661 gtctgactgc aatcgacctg aaggccagtg caatccttgc agtgacaaaa tccggaagta
     3721 cagctcatat gatgtccaaa cacagaccag gatgtctgat cggtgcatgt acaagctctg
     3781 agagagttct tcgccagctg aatctgtcct ggggtgttta cccgatgctg atcaaggaag
     3841 aatacagttc tgagatcctt tgcctgagag caatcgaagc agcacagaag cataaacttg
     3901 taaaagttgg cgacactatt gtatttgccg gtggtgtacc gcttggaatt ccgggaagaa
     3961 caaacctgat ccgcgtctgc acggttgagt aagtcaggaa aatatcagta gttgaagtgg
     4021 gaaacttgcc tgattcgata aaaaatagta ttttcagaaa atataagatg taaaagacac
     4081 aggggtctgc cgtcagaaaa gtatgacaga aaatattttc tgacagcagt cccttgcttg
     4141 tgttagagga gagaattgtt atgaaaacaa atgaggaaga agattcgaga catattttca
     4201 gaggagagct ggcattggtg atagcagtca tgatcaacag tcttgctgtt attctgatgc
     4261 tgtattctgg ttcaggaata tctgccatat ccagtgttcc ttatgcattt gaaaaagtat
     4321 ttccggtaat tacactggga acatggactt atatttttca ggcacttctg atcttaagtc
     4381 tgatgatact gagaaaaaaa tttgtacctg cttatctgtg cagttttctg gttggatttg
     4441 cattcagtga gtttttggat gttaatgagg catggatcaa tatcctgcca aagacaattc
     4501 cactcagagt gttatatttt gtgatcagtt atctgctgat ctgtataggg atcgcacttt
     4561 ctaacagatg cggtctgccg attattccta cagatctgtt tcctcgtgaa ctgtcagaga
     4621 ttataaaggt gaaatattct aagatcaagg tttcttttga tgtgatctgt ctgatgatta
     4681 ctgcctgtat gacagggctg attctggggc atatcaacgg actgggaatc ggaacagtga
     4741 tggcggcatt taccatggga aaagtaattg gattgattgg tgatgagatg gataagcact
     4801 tccggtttgt gaatttcact cagcactgtt cacttcatgt acagtaacag agtttcttca
     4861 ttgcaggatt tttctttcta tgatatactt gacgcattat agaagtaaag atatcataag
     4921 aaatctgtga tggaagtatg ttgcaactct ggtatctgaa aataatatat taaggaatag
     4981 tgatgcagat tatgaaacgg ttgctcataa aaaacaaaag aaagctctgg ctttggtttc
     5041 tgctccttgt ttttttgttt ctggcatgca gagctgctta cattacaggc agcaaagcag
     5101 aacagaccag aaataatgaa gtagaagaaa ggcaggcaga tagtcggtca ataccgaatg
     5161 aaatggagat attatgttga atcaattttc aagaacagag cttcttctgg gaaaagaagc
     5221 aatgaataaa ctggagaact cccgtgtggc agtgtttgga atcggagggg ttggaggata
     5281 tgtatgtgaa gcattggtca gaagcggtgt ggggaccttt gatctgatcg atgatgacaa
     5341 agtatgcctg acgaatctta acagacagat tattgccacc aggaaaactg ttggtcaata
     5401 taaaacagag gtgatgcggg acaggatcct ggacattaat ccgaaagcag atgtgagaat
     5461 ccataactgt ttttatcttc cggagaatgc tgctgatttc gattttagtg agtatgatta
     5521 tgtggtagat gctgtggaca cagtgactgc gaagattgaa ctgatcatgc gtgcaaagga
     5581 ggcagggact cctgttatca gcagtatggg tgccggaaat aagctggatg ccagtgcgtt
     5641 tcgggtggcg gatatctata agactaaggt gtgtccgctg gcgaaggtta tgcgtagaga
     5701 gctgaagaag cgtggtgtga agaaactgaa ggttgtttat tcagaggaac agccgatcag
     5761 accaattgaa gatatggcga tcagctgcag gtcgcattgt atttgtcctc cgggtgctgc
     5821 gcataagtgt acggagcgca gagatattcc gggcagtgtg gcctttgtgc cgtctgtcgt
     5881 cgggctgatt attgcaggag aggttattaa agacctgact gcggagtaca gaagataaga
     5941 agtgtttatt ttgagatgtg tatggtgtca gaaatggtat ggtacacatc tttttttgcg
     6001 ggaaatattt tgaattggat tgatggatta cctgttagag tgtatagaat tgttatatga
     6061 gaaaaagtca aaataacata aaaatttata ggattttcaa aatataatga aagaaaaaag
     6121 aaagaatctg tgatacactg tcattattga ttgatagaac tgtgaaggtg cagaatttgg
     6181 tgaatgagaa tgcctgaacg atatcagcgt aataaattgt tactgcttac tccgttctca
     6241 gtaactaata aatttcagat tggaggatat catatcgaat gaaaacaaat tacaacagaa
     6301 cagtgcaggc ctgttttatc ggatatgtag tgcaggccat tgtgaacaat ttcgttcctc
     6361 tgctgtttct gacatttcag ggcagttacg ggatttcgct gcagaagatc acacttctgg
     6421 ttacttttaa tttcgggatt cagttgctgg tagatctggc atcgattgga tttgtggaca
     6481 gaataggtta tcgtgcatct atgatcctgg cacatgcaat ggcggctgca ggtctgattt
     6541 tgctcacagt attgccggag tgcctgggag atccgtttgt gggacttctc attgcagtta
     6601 tgatctatgc catcggaggc ggattgctgg aggtgctggt aagtcctgtg gtggaagcct
     6661 gccctacaga taataaggaa aaagcaatga gtctccttca ttccttttac tgttggggac
     6721 atgtgggagt ggtacttctt tctacattat tctttcgtat tttcgggatt gcaaactgga
     6781 aatatatggc gctggtgtgg gcattgattc ccattgcaaa tggaatcttt tttaccagag
     6841 ttcccattgc tccactgctg gatgagggtg aaaaggggct gactatggga gagcttttta
     6901 agaaaaaaat cttctgggtt ctgatgttaa tgatgctctg tgcaggagcc agtgagcagg
     6961 cggtaagcca gtgggcttct actctggctg agaaaagctt tggaatcaat aaaactatcg
     7021 gagatctggc aggtcccatg gcgtttgcaa ttcttatggg aagttcaagg gcattttatg
     7081 gaaaatttgg agataaaatc aatctggaac gctttatgca atacagtgca gttctgtgca
     7141 tggtttccta tctgatgatc gcatttatcc cggtacctgc gttgggaatc cttggatgtg
     7201 cggtttgcgg tctgtctgta ggtattatgt ggccgggaac cttcagcatg gcggctgcct
     7261 cagtaaagcg tggcggaaca gccctgtttg ccctccttgc ccttgctgga gatgtgggat
     7321 gctcatccgg accaacctat gtggggatga tttcaggagc actgaatgat aatctgaaac
     7381 ttggaatctt tgcggcactg attttccctg tgttgatgat aatggggatt aagatgattg
     7441 gaagtctgca aaaatatgat tgagatatat taaaaagtat ggaacgatta atttttcata
     7501 ttgatgtaaa cagcgcattt ctttcctggg agtcagccag aagggtaagc cagggaatac
     7561 cggagaaaat gtggccactt cctgtccgta acctgttatt tctgggaaaa gcctccgagc
     7621 agaagcttct gaatcaggga atccgtacta ttggtgatct ggcaagggaa cgggaagcaa
     7681 atgtacagct ctggcttgga gaaaaaccag agcacagatg aaaaatgaag acagacagga
     7741 agaataaaag cgcagagatg atactttttc tctgcgcttt tatagcggac tgttatacat
     7801 atttcaaaaa ttcttcatcc tggatccggg aagtatggat ggcattttgg atagcctgag
     7861 ccatgacttc tgcggcgaga gttcctgcca tattgatatc tacagaaaca tcgccaatgc
     7921 tggcagcata gatggaatcg ccgtcagcca tagttgctac aggattgatg catctggcat
     7981 aggcacagcg ggtcatagag gcaattttat tcagttcagc ctttgaaaat gccccattgg
     8041 tgatcacagc cccgatggtg gtattgccgg taaactggtc atgaggtgtc ataaagcggt
     8101 ataattcgtg gacactatcc agaaacccgc ttctgtcagg cgttttcagc cctgcgattt
     8161 tctgaccatt ttgtggacta aagatatctc ccagtgcatt gacaacgaca attgcggcca
     8221 tctggaaatt tcccactgat acagcggcaa taccaagacc tgacttcatg gattgtttca
     8281 taccgtaaag ttttcccaca gttgcaccgg tacctgcgcc gatattcccg gttctggcat
     8341 ctgttcctgc aaatgcctga cggcaggctt cttcgcccat ttttgcagtt ggacgtattt
     8401 taggatctcc gtaagagagg tcatagatac aggactggca tacaagagga accagggctg
     8461 caccggtgtt ataaccgata ttttgtgatt ccagatagtt catcacaccg tcagcagcag
     8521 ccagtccata agcagaacct ccggacaaga caatagcatt gatgggattg tcggcagtga
     8581 caggagaggt gagaggagtt tctctggaag cagggccgcc tccgcttata tcgcagcctg
     8641 cttttgctcc atttggaaaa taaagaacag ttacaccggt cttcgcatca tggtcagaag
     8701 tatgaccgat gcgtaaattt gaaagctctg taatagaaat ctcttttaat aatgacataa
     8761 aaatctcctt tattatgtga tagcaattct atgaaatact gagagcaatc cagcccatca
     8821 gaatgtgaag tactgcgtca gatattttcc ttgtctttcg cactctgctg aactgtcttg
     8881 attgcattat tttgtgagat tgctatagat attaattgaa tcaggtagga tttctgtttt
     8941 aaatgtgcca gataaaaaaa cctgactacg gtgacaatgt agtcaggttt tttggaaaag
     9001 gctgttcttt taaagattat gcacgtttca gtgccacaga aagtgccttg gaaacgatac
     9061 ttcccactac aaagcagaag cccgcttcga tcagtccctg aacgcccaca aaagcagcaa
     9121 cgaagacaac aggattgctt actccaagac tggaaacaat accctgaatg taatctgtgt
     9181 tgtagaagaa gagacataaa aagcccatga agaagaaagt attcagtaac gggcatgcca
     9241 gtgaagcaac gtaataggaa aatttcttcg ccggtgattt atataatgct gcgaaaataa
     9301 gtcctgtgat ccatccttcc agcacacgtg ccacgataca tacaataaaa gtgccaaatg
     9361 gattaatgtt aaaaagtgca gcagcgaaag ctgaacttcc tgtgacagcc atatagaagc
     9421 tggttgcacc gaaagcaagt ccgcatacag caccaccttt cggtccgagg atgatagctc
     9481 ctacagctac cgggatggtg agaagagtga tggataagcc gggagtacga aggtagccca
     9541 gcggggtaaa ggacatgagc agaataatgg caatcatcat agccagctct accatgtaaa
     9601 gagtgctgct tctttttgcg gcagctgttg tagtagttgt tgttgtgttc atatgaattc
     9661 tccttttggt ctgataaaac ggcgcaatgc gtcccctgct tttcagacag tttagagtat
     9721 ggggatcagg cgttatgaaa aatatgcatc agaacaaaag aaaaatttcc ggtgtgtaga
     9781 cgccttacag gtcgcctcac aaatttaacc agactgtgaa gtggatgact ttatccacca
     9841 gactgtcaga tgtggaaatc agatgcattt tctttcgaat aacgctcccg taaacaataa
     9901 cacatttgat taaaaactgc aatattttat agtatgtttg aaaataaata caggatatag
     9961 agacgtttct atattctgca aaaaatattg attatgagat ttagcgttcc atcatgctga
    10021 tggattcaat tcccacactt ccaccacgta ctacttcgat tctgtggaat tcttccttga
    10081 tcagtttgac aactgcatca ttcttgatgg ctgtctggac aaattccaga agcaggctgt
    10141 ctttgccgta gtcaatgact tttgccttga aggtttctgc aatctgaaac agttctgctt
    10201 tatcttccct ggagcagttg aaaaccttga tatagagaat ttctttcatt ctgacaaata
    10261 catctgtgaa gtcgattacc ttgataacct cgattatgcg gtttaactat tttttgatct
    10321 gttcaaaggt ttcatcatcg ctgactgttg cgatagtcat tcgggatact gtaggatcct
    10381 cggtggttcc tacagtaaga ctgatctatc aagagatatg taaatggtta agtgagtttt
    10441 gttaattaaa atgtactaaa atgtcgtctt ttttgacaag aaattataga aaataaacaa
    10501 aataacacaa tgcaaaaaac aatgcataaa ataaaagaat gtccctttga ggaacattct
    10561 tttaacgtgt ctgaaggaaa acttttaatt tgggaagctg gttgttaagg ataagagttt
    10621 ccggaaacat gagctggtga acgaattctt cggcataggt gaaatctcca acatgttctt
    10681 ttccgtggct gtcgctggac aaaataacag gaagctgata tttctgacag agatacagga
    10741 ttctggcggc attggctctt gtgtctcccc gatatcctcc gggtgcgagg gaagcttcgt
    10801 ttatttcaaa aataacattt tcccgtaaag ctgctcttgc cagcgtttca taatctacag
    10861 ggaaatgtgt atcgtcgcag tggccgagta tttttacagc aggatgtttt attgcattga
    10921 tgtaagcttc tgtattctga gatacagagc ctgaacggta gttctgccga tgcatactga
    10981 tgatagcgta atccaggttg ttcagcagtt catctgacag atctgtatgt cctgcactgt
    11041 ccaggatgtt tagttcaact ccgtaaagaa tatctatgcc gaatcttttt ctgggataaa
    11101 aaggaaggct tctgaaataa gaagaagttc cggaagccag agttcccggg ccgtggtcag
    11161 aaatcccaag gagtttcagt ccttttttgc tggctgcttt tgccatgtca gagatggtac
    11221 aggtggttcc gtgaccgctg gcgatagaat gtgtgtggat gtcagaaaga tacattgttt
    11281 gtctcctttc cagagcggtt tctatatatg ataagagcct tacggaagat gcaaagctgc
    11341 tgtttgatgg tacattcgtt atattcaagt atgacagatg aggatttaaa tgtcaatgag
    11401 gaaacaaaat aaaaacaact gaaatacaac aaaaatcaaa tgaaaagcaa cacaaataaa
    11461 cggctgatac atgttaaatt atgttgactt cgggaaaatg agaaggtata atggaactat
    11521 atgaaaacac gggggcttat tgctgatcaa tgacagcgat ggcactgttt gcttatgtgt
    11581 agacagttac ttcatgagaa aggagtaaca tggaaaaatt tcaaacatca gacattcccg
    11641 gaattctctt atgaatggct ggaggctgaa ctggatactg gtatgattcc acaaatatgg
    11701 acagcgaaga aattgctcct aatctttatg actaatcgat aagtatatat cgagaggaaa
    11761 tgaatcctca gaattaagta aaaaaagtta ccgggaacaa tgtgaccggt agcgaaatac
    11821 agacgccgca ctgccgtatg gcaagtgcgg cgttgttgtt caaaactctg atagcagagt
    11881 gaaatcaaac aaatataaat acagtaacag ctcagacaag atgatgcaaa taaagacact
    11941 tttttggaca aacgaggttc ttaccctgga gagcagatca gggtaaaatg aaatcatcag
    12001 atatgaagag cgcaattcat atattggagg aagaacagtg aaaagtacgg aacggttaat
    12061 ttttcatatt gatgtaaaca gtgcatttct ttcctgggaa tcagccagaa gggtgagcca
    12121 ggggttgccg gatctcagag aaattccttc ctgtgtagga ggaaatccaa agaaacggac
    12181 aggtatcgtg gttgccaaat ctatccctgc aaaaaaatac gggatccaga ccggcgagcc
    12241 agtagctatg gctcttcgga aatgtcccaa tttggtgatc gttcccagtg attttgaatt
    12301 atacgataaa tgttcccggg catttaaagc aatctgtgct tcctttgcac ctgtgatgga
    12361 atctttttcc attgatgagg tatttctgga tatgacaggt acttctctga tctatcctga
    12421 ccctgtagct gctgctcatg agctgaaaga caagattcac agagagctgg gattcacagt
    12481 aaatgtagga atttctacca ataagctttt ggcaaagatg gcatcagatt ttcaaaagcc
    12541 ggacagagta cacactctgt tcccggatga aatcccggag aaaatgtggc ctcttcctat
    12601 ccgtaatctg ctgtttctgg gaaaagcttc cgagcagaag cttctgaatc agggaatccg
    12661 taccatcggt gatctggcaa gagaaagagc atccaatgtg cagtactggc ttggggaaaa
    12721 aacgggacat cagctatggc aatatgccag aggtatcgat gattcccctg taaaagcagt
    12781 gcctgatgag gcaaaaggtt tcagcgtgga aactactttt aacgatgata ttacttccat
    12841 agagcaggtg tttcccatac ttttggagca gtgtgatgtt ctggcaacca gaatgcgcag
    12901 aaaagataag aaatgcaact gtatttccgt gactttccgt actttggatt tcagaaaccg
    12961 ttcacaccag acaaagctgg aaaatgctac agatcttaca gatgaaattt atataaatgc
    13021 tacaagactt tttaaagaat tctggaaagg acagccgcta cgtctgattg gtgtggcact
    13081 gacaggcctt acagatggca cttatgaaca gatgtctctg tttgaagata cagaaaataa
    13141 agaacgccac agaaagctgg atgcagctat ggatgagatc cggatgaaat ttggaaatga
    13201 taagatcacc cgtgccagta ttatgaacag caatgcacgg attgggcgaa aagcgaaagc
    13261 acagatgaaa aacgaaaaga tggaagaacc gtaagtaaag ggaggactga gcattaagaa
    13321 caatgcgaca atcctccctt tataaaaatt tcagaaaaag ttttatcgtt ccatcatact
    13381 gatagattcg attcctacac ttcctccacg taccacttca attctgtgga attcttcctt
    13441 gatcagttta acaactgcat cattcttggt ggctgtctgg acaaattcca gaagcagact
    13501 gtctttgcca tagtcaatga cttttgcctt gaaggtttct gcaatctgaa acagctctgc
    13561 tttatcttcc ctggagcagt tgaaaacctt gatgtagaga atttctttca ttctgacaaa
    13621 tacatctgtg aagtcaatta ccttgataac ctcgatcatg cggtttaact gttttttgat
    13681 ctgttcaaag gtttcatcat cgctgactgt tgcgatagtc attcgagata ctgtggggtc
    13741 ctcggtagtt cctacagtaa gactgtccag attgtagctt tttccggaga aaagtccgga
    13801 gattttggac agaacaccta cctggttctc aacatagaga gaaatccatc tttttttcat
    13861 tcctttatcc ataataatct ttcctcctgc ctaacaatcc atgatcatat cttccagagt
    13921 tccgcccggt ttgatcatcg ggtagaccat ttcttctggg tcaatgataa attcgattac
    13981 tgtaggtgct tttgtatttt tctttgcttc tttgaaggcg gctgcgattt cttctttctt
    14041 tgtaacgcgg attccctttg cgcgatagct ttctgcaagt ttaatgaaat ccggtgtgta
    14101 ctgtggatat tccatgcctt ctgtgcggcg ggaaagtgct ccggcgcgca ggttggtcat
    14161 ggcgtagcgt ttaccgtaga agagtttctg ccactggcgt accattccaa gatattcatt
    14221 gttaaagata cacaggatta ctggaagttc ctccagaact gctgttgcaa gctcctggat
    14281 attcatctgc acaccgccgt caccggagat aacgatgaca ggcctgtcag gatttccgat
    14341 tttggctccg ataccgcccg gaagaccata gcccatggtt cccagaccgc cggacatgat
    14401 catctgtttg ccctctgtga tttccgcata ctgagaaaca agcatctggt gctggcctac
    14461 atctgtaacg ataatgctgt tttcgaactg ttcattgatt tctttcagaa tgtccattgg
    14521 acttaaaaca tcgtttggac gcattttaag cggatgctct tctttccagt ttttgatcag
    14581 gttaagccac ttgtccgttg aacattcctg gacgtattcg ttcattttgg tgatagcctc
    14641 ttttgcatca gcaacaatgg ggatatccac ctgaatgttt cgggaaatgg atgccgtatc
    14701 aatatcaatg tggataatct gggcatgtgg tgcaaattca tgaagttttc cggtgattct
    14761 gtcattgaat ctggttccga tggagaacaa cacatcgcag ttgctgacag ccatgtttgc
    14821 tgcataggca ccatgcatgc cgaggtttcc gatataaagc ggatggtcag taggaatgga
    14881 acctttgccc attacggttg tgacaaccgg tacttttgtt ttttctacta cttcccggaa
    14941 gatttcgtgg gcgcgggaga ttactacacc gccgcctgca aggaataaag gacgttttgc
    15001 cttgtttaaa agtttgatgg cacgtttgag ctgaccgata tggacatctg tgttgggctt
    15061 gtatccgcgg atgtttacat ttttaggata ctcagcgctg ccaagttctg ccattacgtc
    15121 ctttggaagg tcgataagga caggtcccgg acggccggtg cgggcaatgt agaaggcttc
    15181 tttgataatt ctgccaaggt cttcacgtct gcggacagta acgccgtatt tggtgatgct
    15241 tctggtgatt cctacgatgt ctacttcctg aaatgcatcg ttgccgatga ggtggcgggc
    15301 tacctggccg gtgaagcata caagaggtac gctgtcatag ttggcggttg caagtcctgt
    15361 tacaaggttg gttgctccgg gaccgctggt taccagacat acgccgactt tgccggtggt
    15421 tctggcgtag gcgtcggctt cgtgtacaag ggcctgttcg tgacggggga ggatgatttt
    15481 gacatcgtcc tgtttgtaga gttcatcact gatgtcgatg gtacaggctc cggggtagcc
    15541 gaagaggtat tctacgcctt cttcttttaa ggctttgact aagagtttgt tgccggatat
    15601 ttgtttcata ttttggtaaa cctcctttgt gtatgtgtat aggacgctca gaaatttatt
    15661 tgtttggtgt gcggtttcgg agcctagtag atctaagtgt ctgaaaatct gctaaaagcg
    15721 ttcagaaaaa tctcaaactc gctgcgctca gacagtgaga tttttctgaa caacgcagat
    15781 ttccaggcac taagatctac acgactcctg caaatgcaca ccaaacaaat aaatttctga
    15841 gctgtgtatt ggctgataca ggggcagaat ggcgctgcgc tgattctgct gagaacgctg
    15901 taaagcagct cccacaattc tgaatatagt aaaaaacgcc ctgggcttgt ttgcccaggg
    15961 cgaaaatgtt tccgcgg
//
