LOCUS       c00090_gnlPro..        15590 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DFDIIAHB_90.
ACCESSION   c00090_gnlPro..
VERSION     c00090_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:17:52
            Original ID  :: gnl|Prokka|DFDIIAHB_90
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15590
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15590
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1062:5590]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1063..5590
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15590
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15590
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             65..781
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_1"
                     /sec_met_domain="Peptidase_M22 (E-value: 5.8e-28, bitscore:
                     88.7, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEAAKSKGMKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFMAGIYPLAVNMASLSQKAYDDGRFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             850..996
                     /locus_tag="ctg90_2"
                     /transl_table=11
                     /translation="MRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVEDTSTEISPVPIE
                     QAN"
     CDS             complement(1063..2223)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_3"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-153, bitscore:
                     501.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYTIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKLFNLILKDGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(2228..2659)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.1e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIADVEVNGTPYQVKLEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVTRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(2681..3568)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_5"
                     /sec_met_domain="OAD_gamma (E-value: 4.7e-13, bitscore:
                     40.1, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHTLFWADGQP
                     DRGTFHVNFVLDPSKENYIALYDADGKTLIDEVTIPAGQMADISYGRVIDGKDEWAQLK
                     KVTPSTNNLTLDSNEKIDNFKQNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGRLSISA
                     SKRNAQKAAGTTSVSVDAGQESGEIFAAIATALYEMSDDNHDIEHTVLTIHKVQRTYSP
                     WSSKLYGLRQTPHK"
     CDS             complement(3590..5143)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_6"
                     /sec_met_domain="CT_Btheta (E-value: 1.7e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(5180..5590)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.5e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             complement(5719..8130)
                     /locus_tag="ctg90_8"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISIIYSCLGYNKAERIIPSAQADMRLNVQMNYTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKRPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPNDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRKVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             8252..8812
                     /locus_tag="ctg90_9"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEEDSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKETGE"
     CDS             8809..9576
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_10"
                     /sec_met_domain="F420_oxidored (E-value: 1.7e-09, bitscore:
                     28.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVIPEEIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYPLQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPVRAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             9569..10090
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_11"
                     /sec_met_domain="HAD_2 (E-value: 1.4e-08, bitscore: 25.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEH
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             10128..10709
                     /locus_tag="ctg90_12"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRVISDIDESYPDS
                     IDSMEIPLYIARSKAEAYKPTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(10712..11089)
                     /locus_tag="ctg90_13"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNSTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(11098..12126)
                     /locus_tag="ctg90_14"
                     /transl_table=11
                     /translation="MRKNISILVSLLILSLTACSDKGQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFIKAEEISKKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             complement(12152..13876)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_15"
                     /sec_met_domain="ILVD_EDD (E-value: 2.5e-183, bitscore:
                     600.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAREELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMKEIKEFLHLDVKTVTGRTLGE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARRLD
                     IIGTGGIERSAEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             complement(13921..14487)
                     /locus_tag="ctg90_16"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSTKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             complement(14489..15010)
                     /locus_tag="ctg90_17"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAVNYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDTAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKRRKP
                     IEEIIKRESF"
ORIGIN
        1 taatcagatt gaaggattga gattgtttgt tcgttcaatt atcaattgtt aatagttaat
       61 tattatgtca ttgatcttaa atatcgagac atccacttcc gtatgttcag tagccctgtc
      121 ggaaggggag gaggtggtct ttgagaaggc ttcctttgag gggccgtctc atgcggcgtt
      181 attgggcgtt tatatggaag aggcattaga ggccgcgaag tcgaaaggga tgaaactgga
      241 tgccgtggcg gtaagtagcg gacccggatc ttatacggga ttacgcatcg gggtgtctgt
      301 ggctaaagga ttatgctttg ggtatggtat tcctttgatc ggtattcata cgctggatat
      361 tttagcgtct gccgctatcc ggaaaaataa ggaggaggcc gattgcttgt attgcgctat
      421 gttggatgcc cgccgtatgg aagtctactc ttcgatttat gattcccatc tcaacacgat
      481 acgtgccacg actgctgata tcgtagatgc tgattcgtat gcttcttttt tagagaacgg
      541 taaggtttgt ttctttggag acggtgccgc taaatgtgag acggtaatca cttctccgaa
      601 cgcctgtttt atggctggta tctatccatt ggctgtaaat atggcatcct tgtcgcagaa
      661 agcatatgat gatggccgtt ttgagaatgt ggcttatttt gagcctttct atttgaaaga
      721 attccaagca acgatcgcta agaacaaagt gctgaacgag gcgttaggga aaaacaaata
      781 agagtaaggg tacacaacca aattcatgtt ccggctgttt attctaaaat gaataaatca
      841 gttaaagaca tgagaaagaa aagtgtgaat acgctattgg tatttggtgt ggttgtcgct
      901 ataatccttt tgatgatctg gttgttcctc gggacaacgt tggtggagga tacgagtacg
      961 gagattagtc cggttcctat agagcaagct aactgagaac aataacataa aaaggcggga
     1021 tcctttcgga cctcgccttt tttaatatag atagttgttt tattaaccaa ggaatcctag
     1081 caagataccg gcagctacag cggaaccgat tacacctgct acgttcggac ccatagcatg
     1141 catcaacaag tagttggtcg ggtcatattc caaacctacg acttgagaga tacgagctga
     1201 gtctggaaca gcagatacac cagcgttacc gataagcggg ttaatcttgt taccgtcttt
     1261 caatattaaa ttgaacaatt taacgaacaa tacaccggca caagtcgcga tcacgaaaga
     1321 caatgctcct aaaccgaaga tcttgataga gttcaatgtt aagaattgag tagcttgggt
     1381 agaagcacct accgtgatac ccaataagat cgtgattgta tcgatcagcg gaccacgagc
     1441 agtctctgcc aaacgacgag tcacgccact ttctttcaat aagtttccga agaatagcat
     1501 acctaacaat ggtaaaccgg acggaaccaa gaagcaagta agcaacaaac caacgatcgg
     1561 gaagataatt ttttccgtgg aagaaacggc tctcggcggt ttcatacgga tcaaacgctc
     1621 tttcttagtc gtaagcaatc tcatgaacgg cggttggata ataggaacca acgccatgta
     1681 tgagtaagcg gataccgcga tcgcacccat taagtttggc gctaacttag aagaaaggaa
     1741 gatagccgtc ggaccgtcag caccaccgat aataccgata gcacctgctt ggttcggctc
     1801 aaatcccatt tgaagagcaa tcgtataagc accaaagata ccgaactgag ccgctgcacc
     1861 gatcaacatc aacttaggat tggagatcaa tgcggagaag tcggtcatgg ccccgatacc
     1921 gaggaagatc aatggcggat accatccaga ggtcacaccc tgatagagga tgttcagtac
     1981 agacccttgc tcataaatac ctacctgaag acctgcgtcc ttgaaaggaa tattaccgat
     2041 caagatacca aatccgatag ggatcaaaag catcggttca aactcatatt taatcgccag
     2101 gaatataaac aacagaccta ccagaatcat gatgagatgt cccggagtag cgttgtatac
     2161 acctgtatag gtaaggaaca gttgtaagtt ctcacctaag aatgttaaaa agctctcttg
     2221 catagtctta tccgattact acgagatcag caccttctag cacagagtct cccttgtgta
     2281 ctttaatttc tataatctta ccgtcacggt ctgcgttgat gttgttctcc atcttcatag
     2341 cctcaaggat aatcaatgtt tgacctctct tcactgtatc acctacgttg cacttaacct
     2401 gcaagataac acctggtagc ggagtcttaa cagcgccttg tgtagtagag gctgccggac
     2461 gagtaactac agggtcgcca cttgctgttg tcggtgcttg agccggacgt ttcaatgtaa
     2521 ccatttgttt cttcgccggt ttctctaatt ttacttgata aggtgtacca tttacttcaa
     2581 catctgcgat gtcatccact acagaattga tgtgtacttt atatacgtta ccgttaatgg
     2641 tatatttaaa acttttcatt ctttgttcgt ttttagataa ttacttatgt ggggtttgac
     2701 gcaaaccgta gagttttgaa ctccaaggag aataagtcct ttgtaccttg tggatcgtaa
     2761 gaaccgtgtg ctcgatgtca tgattgtcat cactcatctc gtacaaagcg gtagcgatag
     2821 cggcgaagat ctcaccagac tcttgtccgg cgtcaaccga tacacttgtt gttcccgcag
     2881 ctttctgagc gttacgtttg cttgcggata tagacaatct accgatctgc ttaaagatga
     2941 tgtataacaa aaataatccc aagaacacta cagccatagc ggtaatggtc ataccgatac
     3001 ctaaagagtc attctgtttg aaattatcga ttttctcatt agaatccaat gttaggttat
     3061 tcgtactggg agtaactttc ttcagctgtg cccattcatc tttaccatcg atcactctac
     3121 cgtaactgat atcagccatt tgtccggcag ggatcgtaac ttcgtcgatc aatgttttac
     3181 catctgcatc atacagagct atataattct ccttagaggg atctaatacg aagttaacgt
     3241 ggaatgtacc tctgtccggc tgtccgtcag cccaaaatag tgtgtgctgg cggggttgga
     3301 tctgagttaa tacgtctccc ttcgggatcg gatatttcat gggattgttt ttgtcgtctg
     3361 tcaaataaca tcccgcgata tttaccgttc cggccgaagt gttgaacaac tcaatccagc
     3421 catgacgttt gccatagtca tcaacgaagt tatcctcgtt gataaccaat acttcattaa
     3481 ttcgcatgga ggttgcgcgc tgtgcctttg ccccgaatga aatgagcaaa gcgaacagta
     3541 gcaatacccc tattttctta tttatcatat tcatctcctg ttttacggat tatagaggca
     3601 ggttatcatg tttcttagca ggattgctta acttcttagt ctgcaattgc tgcaaagcac
     3661 gaataatacg gaaacgagtg ttacgtggtt cgataacatc gtcgatataa ccgtattgag
     3721 ctgcgttata aggattagcg aatgctttct tatattcagc ttctttctct gctgcgcatg
     3781 ctttcggatc ttcagcggct gctacttcct tggcgaagat aacctctacg gcaccgctcg
     3841 ggcccataac agcgatctcg gctgtcggcc atgcgtaatt catatcacca cgtaaatgtt
     3901 tagaactcat cacgcaataa gctccaccgt aagacttacg caatgtaacg gtaatcttag
     3961 gaacggtggc ctcaccataa gcgtaaagca atttagcgcc atgaaggatt acaccgttgt
     4021 attcctgacc tgtacccgga aggaatcccg gaacgtcaac caatgttacc aaaggaatat
     4081 tgaaagcgtc gcagaaacga acgaagcgac ctgctttacg agatgcgttg ctatccaagc
     4141 atcctgccat aaccttcggc tggttggcta cgataccgac agattgtccg ttgaaacgag
     4201 cgaaacctac gatgatattc ttagcgtaat ccgcatgaac ctctagaaac tcgttgttat
     4261 cgacgattgt accgataacc tcatacatat cgtaagattg gttagcgtta tcgggaatga
     4321 tatcattcaa tacatcgtcc aaacgatcga tcgggtcttt acactcaact aacggcgttt
     4381 cctctaagtt gttctgaggt aagaagctga gcaatttacg aatcaattgc aaaccatcct
     4441 cttccgtatc aacagcgaaa tgggctacac ccgattttgt agtgtgtacg ctggctccac
     4501 ccaactgctc ttgggttaca tcctcacctg ttacggtttt tacgactttc ggaccagtca
     4561 agaacatata gctggtacca cgtgtcatga tgttgaagtc tgtcaaagcc ggagaataaa
     4621 cggctccacc ggcgcaaggg ccgaagatac cggaaatctg aggaacaaca ccggaagcca
     4681 agatgttacg ttggaaaatc tctgcgtatc ctgccaaggc gtttacacct tcttggatac
     4741 gagctccacc agagtcgttc aaaccgataa cgggagcgcc catcttcatg gcttgatcca
     4801 ttactttaca gattttcata gccaaagcct cagacaaggc tccaccgaat acggtgaaat
     4861 cttgagcgaa gatatatacc aaacgtccgt cgatcgtacc ataacctgtt acgataccat
     4921 cgcctaaata tttagttttc tcgataccga agtttgtaca acggtgttga acaaacatgt
     4981 cgaattcctc gaaactacct tcgtcaagca acatggcgat acgctcacga gcggtatatt
     5041 tgcctttttt gtgctgtgat tcgattcttt tctctcctcc acccaagcga gcttgctcac
     5101 gaagtgcgat gagctctttt actttttcaa gctggttact cattgtattt tgatttgttg
     5161 ttagaaatga acggattaat tatttgttgc ccggcatgca aagttctgtc aatacgctgc
     5221 aagttgattt cgggtgaagg aaagcgatgt tcaagccttc cgcgccacca cgaggagctt
     5281 tatcgattaa tttaacgcct ttttcctcag cctcgttcaa agctgcctgt acatcaggta
     5341 ccgcgaatgc gatatggtgg ataccttcac cttttttctc gataaatttc gcgatcgtgc
     5401 tatcttcgct ggtcggctct agtagttcaa tcttagtctg tcctaccttg aaaaatgcgg
     5461 tttttacttt ttggtctgct actacttcga tattgtagca ttttaatcca agaacgcctt
     5521 cataataggg taaacaagcc tcgatactct tcactgcgat acctaaatgt tcgatatgtg
     5581 taagttccat gtcaataata atttaaagat ttagtaaatg tttgtttcta ttgtgtgcaa
     5641 atgtacacta ctttttatga atgaggaaat aattttttgt ttttatctcc cagtaaatgt
     5701 gtttaaagat acattttatt aaaaatcgac aatcagacga acgttcaatt gacgtccggt
     5761 cagatagttt ggaactgcgt attggacatt atatacatct gttatccaat agtaggaact
     5821 aacgtttttg atgtctaata tgttaaacac atccagacct agccaaatgt ttttcaaatg
     5881 gcggaagaag cccctgtcca tgatagcgtc cgtgcctcct gccaattgat aggagaggcc
     5941 gatatctaca cgtttgtagg cgggcgtacg gaaatagccg gcttcgtatc ctttgcccgg
     6001 gattgtctgg ggaagtcctc cggatagaac tcctttcaga tttagcttga ctcgtttata
     6061 gcccgggaaa taatcttgga agaagagtga gatgttgtag ccttggctat tggccatagg
     6121 aacggtcgtt gtttcccgga tggtttgctg ggctttcatc aaggagaagc tgatccatga
     6181 gtcggtaccc ggtacgaatt ctccgaagaa tttgacatcg agtcccatgg cgtaaccttt
     6241 ggcgcagttc tcaccgtaat agcggatctt gacgttatct acggtgtagg gattcagatt
     6301 gtccagcttt ttatagtaca tctcggcggt caccttgaaa ttccggtcta cggcacggaa
     6361 cgtataatct cctcccaata tgaaatggat ggagcgttgt gactttagat ctttgttcaa
     6421 taccgtgata ttattgccgt tcttatcttt gtctacttta cgtaattcct tgtagaaggg
     6481 cgattgataa tacagtccgg tggcgaaacg gagcgtcaag tcttggtcga agttcgggat
     6541 aaagcccaat gaggcacggg gactgaaaag gaactcctta ttataagtcc aataactacc
     6601 tctaacccct gcgactaacg tgaacagacc ttgcttggtc ctgaatttga atgcgtcttg
     6661 cgcataagcg gaaaagcgtg tgctttctat ctgattatca gaaaagaggt tcgaatatac
     6721 acttacgtta ttaccggttt ggggcaaaga ataacctgag gaatcccttt tttcccattc
     6781 actgatctta tcattgattt tctccatttg taccgtggct ccccatttca acgtattgtt
     6841 taaaaggcgg gccatcccat agtgcccgac attcatgacg gtggagttca aacggtttcg
     6901 tgcgtgctcg tgataacggc ctacggacat ggcggctgac gcgtcgtcat tcggattttc
     6961 cgctccgttc tcgctcagcc aatattctcc ggcgatatcg tatccctctt cttccttgct
     7021 tttgaaagcg gaggcttgaa gtcccaactc tgtgttctca ttggggttgt gtttcaatgt
     7081 aagcgcaccg aataaggttt ggaaacggtc tctttccctt ccgtcgaaat agactttgaa
     7141 gttcttggga tgctcggctg taccgaaaga ggtttcccgg ctataagggg tgaatttata
     7201 attattgtta gcgaggtttc ccaagaaatt gatttcccat ttaggggcca attggtacgt
     7261 gatgtaagtt tgcaaatcga taaatttagg gtcgtattct gcgtctgtat ccatggtacc
     7321 caaaatagac cgaccgcttt taaagcggaa acccgttact tgggtaaatt taccgataga
     7381 actgcctaca taagcattcg cgcccaacaa gctcgcagaa gccgagcctt cgaatatctt
     7441 aggtctttta taggtaatat ccagcacaga actcatcttg tctccgtaac gagcctcgaa
     7501 gccaccggcg gcgaaattga ccgcctccgt taggtccgga ttgataaagc taaggccctc
     7561 ttgttgtccc gagcgaatca gaagtggacg gaatacctcg atcccattca cataaacgat
     7621 attttcatca taactacctc cacgtacgga atactgggaa cttaactcgt tattggacga
     7681 tactccggca aacgtaacga ccaagctctc tatactacct ccggaaggat cgggcaataa
     7741 cttgattttg tccgcattta gggactccat ggtcgtggtc tgcttgcgga tggcagtaac
     7801 agatacttcc cctaaatcaa atgaggtata gttcatctgt acgttcaggc gcatatcggc
     7861 ttgtgctgaa ggaatgatac gttcagcttt attatatccc agacaagagt aaataatgga
     7921 gatagaatcc cccggcgata tggaaaagga ataatatccc ttctcgttgg tcatggagcc
     7981 gatcaacgtg ttcttaaccc ggacattcac taattccaga gggttaccgt cggcgtcacg
     8041 gacataacca gtgattttta tgcggccttc gccaaaggca ctcacggaaa taagtataaa
     8101 tagcagcgcg gctatcgcac gaatcttcat aatctattgt tcaattataa aaatactaac
     8161 gagaaaaaag aacgatacgt atatatgggt gcaaaaaatt atatttatat ttgcgaatct
     8221 taatattaaa agagtacaaa gaacgaaaaa aatggagagt tttgcaacac ttatacaaaa
     8281 tagaagaagt acacgtaagt ttaccgaaca actactttca cccgagcagg tagaactgat
     8341 cttgaaggcg gcgttgatgg ctccggcctc aaaacgtagt aatccttggc agttcgtggt
     8401 cgtggaagat aaggaaatgt tgaagaaact tgccgggtgt aagaaaaatg gttccgcttt
     8461 tctggagggt tgtgccttgg ccgtggttgt cttggcgaat gtgatggaaa gcgatgtttg
     8521 gatcgaggac gcttcggtcg cttctattta tatgcaattg caagcagagg atttgggatt
     8581 gggcagttgc tggtgtcaga tccggaaccg ggtaacagag gacgaggagg attcgaataa
     8641 ttatgttcgt tcgttgctgg atatccctta tcaattggat gtcttgtcta tcattggtat
     8701 cggttataag gatcaggttc gtaagccttt tgatgaatcc catttacaat gggagaagat
     8761 acatatagga aagttctctc ttccggaaga aaataaagag acgggagaat gagagtcgta
     8821 tttgttggtg ccggaaactt agctacccgg ctttcgttgg aaatgcgtaa gtctggaatg
     8881 agtatcgggc aagtatatag tcacacaagc gagcatgcta agattttagc tgatgaattg
     8941 ggatgtgggt ggaccgtgat cccggaagag attgtggaag atgccgactt gtatgttttc
     9001 tctttgaaag atgccgtgct ccaagatgtt atcgcccgtg taaaaccgaa taacggtttg
     9061 tgggtgcata cggcagggag tatgcctatc tctgtatttg aaggtcttac ggctagatat
     9121 ggggtggttt atccgttaca aacgtttagt aagagtaggg aagtggattt caagaaaata
     9181 ccgttctttt tagaggcgaa ctcgtctgaa gatgagaagg tgctgggcga ggtggctagg
     9241 gcgctctcca gtgatgtccg tttcctctcc tccgagaagc gaaagaactt acatttagcg
     9301 gcggttttcg cttgtaattt tacgaatcat atgtatgcgc tagctgaaaa gatcttggaa
     9361 gaacagcaaa taccgggaga ggtcttgcta cctttgatag acgagacagc cgctaaggta
     9421 catgtaatgt cgccggtgcg agcccaaacg ggaccagcta tacgatatga cgagaatgtg
     9481 ataaacaaac atatggctat gcttaaagat ccggatatgc gaaatctata tgagctgatt
     9541 agccgaagta tacataagga ggctcgacat gagtagtata aactatgatt tgagaaaaat
     9601 aaaggctttt gtctttgatg tagacggggt gctatcctgc gatgtgattc cgcttcaccc
     9661 gaatggcgat ccgatgcgta ctgtcaatat caaggatggc tatgccttgc aattggccgt
     9721 gaagaaaggt tatgaggtcg ctataattac gggcggatat acggaagccg tacagattcg
     9781 cttttctcgt ttaggaatac aacatattta tatgcgtagc gctgtaaagg tgcatgactt
     9841 taaggatttc atggaaaaaa cgggcttgtc tcctgagcac atcatgtatg cgggtgatga
     9901 tattcctgat tatgaggtaa tgacgcgagt cggattgccg gtggcgcctg cggatgcggc
     9961 tccggagatc aaggagatag cgaaatatat atcctcccgg cgaggtggcg aaggcgtagc
    10021 tagggacgtg atcgagcaaa cgatgcgggc tcaaggacac tggttcggcg aggaggcttt
    10081 tgggtggtaa aattttggtg aatgtgtaac gcttaatcga ataggttatg ttagagaatt
    10141 taaaaaagta caagatcgtc ttagcctcta attctccgag acgacggaat ttgttatctg
    10201 gtctggatat cgacttcgag gtgagggtaa tttcggatat tgacgagtct tatccggatt
    10261 ctattgactc catggagatc cctttatata ttgcccgttc gaaagcggag gcctataaac
    10321 cgactatggc ggatgatgaa ttgctaatca cggcagatac gatcgtttgg acgtttgacg
    10381 gggttatggg aaagcctgcg aatcgagagg aagcttatgc tatgcttcat gctttgtcgg
    10441 atcatgtaca tcaggtaata accggtgttt gtatcatgac gaaggacaaa aatgtaggct
    10501 tttccgtcga atctgcggtt tgtttcgcta aattgggtga tgaagagatt aattattatt
    10561 tggataaata taaaccttat gataaagcgg gagggtatgg cattcaggag tggatcggtt
    10621 atatcggggt agaggctatc aatggtagtt tttataacgt gatgggatta cctgtgcaaa
    10681 agctttatca ggaattgaaa catttttaat ctcaattcaa ggtaaagtat ttatccttca
    10741 tataatattc tatctgattt aatgtgtgcg ctaaggctgg gggaatcggt aagacgaccg
    10801 gtttctccac attccattcc gggtcattta tgatcatgtc ggatagactg cccgcatgta
    10861 ttaagataag gcgggtaggg gctgaggcta taaccttatg attggtgttt tgcgcaagta
    10921 gcatgaaatg atcttttgcc acttccgcta tatgtgtccc ttcttggctg taaataataa
    10981 gttttcccga aaatacgaag attaataggt tatccgtggt tgtggaatta aacagggaat
    11041 ctccggctct cagtattttg cattcaagtt gatttagata acgcttcatg taggaactta
    11101 aggattttcg aggatagcca atgtttttct gttaggaagg tattccaaca taccttttga
    11161 gtaggtgact ttctgttgtc cgttgttgtc cgcataaata atgaaatact ctatttgggg
    11221 gatggattgt gccagtagct tcgctttctc gactcccaaa accatgaaag tcgtagcgta
    11281 agcgtctgct gtcatacaat cttccgccac gattgtcgca ctaagaatat tttgtccagc
    11341 gggataaccg gtcgctggat tgatcgtatg ggcatatttc ttaccatcct tgatgtagaa
    11401 gtttcggtag tcaccagaag tagccacccc ccctttttgg cataattgta cgatctcttc
    11461 aacatcattt gttacgccac ttgtccctat ttccggcttg ttgatgccga ctcgccaaca
    11521 gtcaccttgt tgatttacgc ctttcatggt gacctcacca cctatttcta ccatgtagtt
    11581 ctttacgcct tctttttcca gcaggcgggc gataacatcg caagcataac cttttgcgat
    11641 ggacgaacaa ttcaatagaa tccggggatc ttctttgatg attttctttc cttccaatct
    11701 tactttttga taaccgacga aagccttgat gctatcgatc atctgcgggg ttacgctgtc
    11761 catcttactg aatccgaatc cccatagatt aattaatgga gcgcaagtaa tatcaaaagc
    11821 tcctcctgat tttttggaga tttcttccgc cttaatgaat acttcggtaa accattcatc
    11881 tacctccaca tcctcgttat tattgacttt agcgatcgtg gagttggggt tgaaaggatt
    11941 taaggagagg ttaaaacgtt gcagctcgct gtcgatctta tcggttagga tttgcttggc
    12001 cttgtatttg atgtggtaac ttgtatgaaa aacagaacca ctctcttcga aatattggcc
    12061 cttgtccgag caagccgtaa gcgataagat caacaggctg actaatatgg aaatattctt
    12121 gcgcatcatt atgaaatttt atgtcgcgaa cttacataaa aaattccata tatgcccctt
    12181 tcatggggga gacgctattg tgtgtataaa tatcaaggat tcctttttta tattgtgact
    12241 ctggttttat ccaatgtgca cgcctttcgg ataggatctt ttctatttct tccgcgcttc
    12301 tctcgatacc gccggtaccg attatatcca atcttctcgc tggaatatcg atacggatca
    12361 agtcatcgtt ctctaccaag gcgatcggtc ccccctcgga agcctccggg gatacatgtc
    12421 cgatcgccgg gcctcgggtc gctccggaga aacgaccgtc ggtgatcaat gcgatggtct
    12481 ctaccaactc aggatcggag gcgatcgctt ctgtcgtata aaacatttct ggcattccac
    12541 ttcctttcgg tccttcataa cggataaata ccgcttctcc cgggtggatt ttcttttgta
    12601 ataccgcctc aatagcgttc tcctcacaat cgaataccct cgctttcagg gtgacttgca
    12661 tcaagcgggg tgaaatcgcc gaatgtttta cgactgcccc ttcgggcgct aaatttcctt
    12721 tcaatatagc gatggctcct tgtgccttga tcggtgtgtg aagaggtttg ataatatcgc
    12781 caacctttac tcctagggca ggaagatatt tatggcaatt ctcatagaag ccgttgagct
    12841 gtaaatcttt taagttttct cccaatgttc tgccggtaac ggtcttgaca tcgagatgga
    12901 ggaattcctt gatttctttc atgatcgccg gtacgcctcc cgcataccag aaatattcgc
    12961 cgggccaaaa accgctggga cgtatattta aaaggtaggg gatcttacga tgtatcttgt
    13021 cgaacaaatc cggtgataac tggattccca gttcatgggc gatagctgga agatgaagca
    13081 ggctgttgct ggaacccgct atggcggcat gtaccatgat cgcattttca aacgcttgta
    13141 tcgtcatgat atcggagggt tttaactctt ctctcgccag tccgagcgca tgttctccgg
    13201 ctttacgggc ggtttctttt aactcgggta aatgggcggg gatcaaggcg gaacccggta
    13261 aagcgatgcc tagcgcttct gccattactt gcatcgtaga ggcagtgccc atgaaagagc
    13321 aagctccaca atccggacat gcgtcacgct tataaaccat gaattgttct tccgttattt
    13381 cttttcgctc gtactgggcg ctataggtac cgatttgttc taacgtgagt aggttgggac
    13441 cggctttcat tataccaccg ggcatgaata tagcaggcat atctagccgg gctatcgcca
    13501 tcaaatgcgc agggacggat ttgtcgcaac tggctataaa gacaccagcg tcgaaaggag
    13561 tcgcttttac atgaatctcc atcatggcgg ccatgatatc acgggagact aatgagtagt
    13621 tcataccatc gtgtccctgc gcctctccat cacaaatatc agtgacgaag tagtttgcgg
    13681 cacgtccccc cttttccttt ataccgattc cggcctcgtc caccaattta tccagatggg
    13741 cgcttcccgg atggctatgt ccgtaactgc tttctacaat gatttgcggt ttactcaatt
    13801 cgtcgatttt ccaaccgctg cctagccgga gtgaatccag ctccggcgct agttttcgta
    13861 attgctggct tttcatgtct attaattaat gtataaggtt atttattcaa taaggtatcc
    13921 ctagctaaag aatacatgct ctatcaaaat ctttgtaccg ataccgatta agattaaacc
    13981 tccgatgagg tccagcttca agtcgattct cttgccgaat cggttaccga aatagacgcc
    14041 gaaggcagag atagcgaagg tgacaacacc gatagtcgag gcttgcagca agagcggtga
    14101 ttttaagatc gccagagaga ttcctacggc gagggcatcg atacttgtcg ctattcccaa
    14161 tccgcataat gtccggttac atagaggatc gaatttcccg tcttcctcct cttccttcgt
    14221 gctatcgtat atcatttttc cacctaagta aagcaagagg gtaaatgcga tccaatgatc
    14281 gaaggcgcaa atgtattttt cgaatcctaa tcccatcgta taaccaatca cggtcattcc
    14341 ggcttggaat ataccgagca cgctcgctat cttaataata ttaccggcgg tgcagttgtt
    14401 cttaagaact gcgccgccgg taactgatac tgctaggcta tccatggata agccgatcgc
    14461 tagtagcaga acttcaatgt ataacatact agaatgattc ccgtttaata atttcttcta
    14521 tgggcttacg tctctttgga gtctcatcga ataatgccgg gtcggaagga tagccgaacg
    14581 gtatcaatac aacaggctcg atcgtttccg gaattttaaa atgtttacgg caaagctccg
    14641 tgtcgaaatt gcaaacccaa caagtaccca atccttgttc ggcagcggct aaacaaatgt
    14701 gttccgtggc gatagccgta tcgatatcca tatgatcctt atgatcgccc cgtttccaag
    14761 attgctgatg atctccgcaa acgatcaagt aataaggcgc ttgcttgaac cattcccggg
    14821 gatagcattc ttgtaattta gcttttcctt ccgcactttg aacccataca aaataccaag
    14881 gttgataatt taccgccgaa ggggccaaac gagctgcttc taggatataa tcaatctttt
    14941 cttgctctac gtttttgggg gcatactttc ggatagagca acgttttctc gctaattcta
    15001 ggaaactcat atctcatcct ctattttata gttattgcga ttcggagaat tgcgggaaat
    15061 caactccccg ataaagcccg ctaggaacat ctgggttccc agaatcatcg ctgtcaatga
    15121 aatatagaaa taaggggaac ttgtaaccaa aggtcttaga tctccagagt acatcgagat
    15181 caatttcatg ctgagtacga ttactagagc gataaaacca atgaagaaca tagcgcttcc
    15241 ccataaaccg aagaagtgca tcggtttctt tccgaatttg gaagtaaacc aaagcgtgat
    15301 caaatcaaga taaccgttca cgaagcgatc caacccgaat ttagtagttc cgtacttgcg
    15361 ggcttgatgt ttcactactt tctcgccaat cttgtgaaat ccggcaatct tagctaaata
    15421 aggtatgtaa cggtgcatat cgttatacac ctctatattt ttaatgacaa cattcttata
    15481 cgctttcaat ccgcaattga aatcgtgtaa gttctttatt cccgagaatt tacgagctgt
    15541 tgcgttgaat aatttcgtgg ggatcgtctt agacaacggg tcatatcttt
//
