LOCUS       gnlProkkaNMEGLINO_40   14089 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NMEGLINO_40.
ACCESSION   gnlProkkaNMEGLINO_40
VERSION     gnlProkkaNMEGLINO_40
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 06:24:51
            Original ID  :: gnl|Prokka|NMEGLINO_40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14089
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14089
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3822:4089]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3823..4089
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14089
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14089
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..913
                     /locus_tag="ctg40_1"
                     /transl_table=11
                     /translation="MKPTLFLLAAGMGSRYGGLKQLDGLGPNGETIMDYSIYDAINAGF
                     GKLVFVIRKDFEQDFRDKIISKYEGHIPCELVFQSIDDLPEGFTCPEGRTKPWGTNHAV
                     MMGADVIKEPFAVINCDDFYGRDSFQVMGKFLAALPEGSKNVYSMVGFRIGNTLSESGT
                     VSRGLCGTDANNLLTSVVERTKIQRMDGEVKYIDDNGEWTATPETTPVSMNFWGFTPDY
                     FAYSAEFFKSFLSDPKNMENLKSEFFIPLMVDKLINDGTATCEVLDTTSKWFGVTYPED
                     RQSVVDKIQALVDAGEYPAKLF"
     CDS             complement(958..2628)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 277.7; E-value:
                     3.2e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_2"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRFSCRFPAGSCIAIVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETSHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASQEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(2651..3814)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_3"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.9e-45, bitscore:
                     146.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPASFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             complement(3823..4089)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_4"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.5e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.6e-15, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             complement(4102..4461)
                     /locus_tag="ctg40_5"
                     /transl_table=11
                     /translation="MRGNSMNPFLVDRRDRVTLGDFTTEQLQPGVTVLARDLTERIVFH
                     RIIRRNGDILILQGDGNLAQTEETDIGRVMGVMTEAMRKDKRYTADGKVWKLYSYWWMK
                     LNPARRWLLALFRRI"
     CDS             complement(4569..5480)
                     /locus_tag="ctg40_6"
                     /transl_table=11
                     /translation="MDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKVIFETE
                     IDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWMECNDNF
                     RQCFIHLPACRTETPVPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATETGKGYL
                     FLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTPCYRKE
                     SMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTELATLAP
                     VYHLKCLPDREATELCRKTVEG"
     CDS             complement(5742..8942)
                     /locus_tag="ctg40_7"
                     /transl_table=11
                     /translation="MTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMAAMIKLTVN
                     KIPAEATTFKIIASNNIAGTCTVDLTAADPILTVASNGSKEITASFTASNDIKSRNFYI
                     PLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVDATTPSALSTA
                     LADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFNTAPTTSTA
                     APLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTLAAVGNKAT
                     YNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGNTTIYIIKGTEASL
                     PATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLDLNGYTLTA
                     DNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDASMTMESGNI
                     SAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIINITDGELIS
                     TADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGSTGNWGDGTG
                     GLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFSDPSALKYM
                     KANANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETNSCQLLEGS
                     NVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINNTTINAGSN
                     ANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTELMKLNITSGTFNGDLKV
                     DASVGTENAQSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTELATGYILNAA
                     NATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASATAKDDGYRM
                     VIEARGYGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYGTPNNDTDG
                     RYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDGSVYTAAHK
                     VGDGRKEYIVGQTSQENR"
     CDS             9145..9351
                     /locus_tag="ctg40_8"
                     /transl_table=11
                     /translation="MYSSFTVVRVSVPAPSNVALTVMFPFRPLFSNSSWLQLNAVKAAV
                     AMQATCIRFLNFIIMKSPLVFYG"
     CDS             complement(9334..9549)
                     /locus_tag="ctg40_9"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             complement(9915..10241)
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWRKELRTREKTKQPPCKLPDRASRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             11107..11439
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TAETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             11674..12450
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg40_12_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_12"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        11827..12108
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg40_12_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg40_12_oMT.1"
                     /locus_tag="ctg40_12"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(12525..12704)
                     /locus_tag="ctg40_13"
                     /transl_table=11
                     /translation="MEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRH
                     TGIPPQKFRTSSKQ"
     CDS             complement(12717..13373)
                     /locus_tag="ctg40_14"
                     /transl_table=11
                     /translation="MNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGAGKVMMDK
                     FHIIGKHYIFPLSKTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKE"
     CDS             complement(13384..13614)
                     /locus_tag="ctg40_15"
                     /transl_table=11
                     /translation="MRNIRIHQNWFIIQEAKFGLKCLYHKQTLINQYSILICIYSIIHN
                     FTLFNRDKLSVILILTVTSVIYTLLSPIFAS"
ORIGIN
        1 tatgaaacca actttattct tattggcagc cggtatgggc agccgttatg gtggcttgaa
       61 acaattggac ggattgggac cgaatggcga aactatcatg gattattcta tttacgatgc
      121 catcaatgcc ggttttggca agctcgtttt cgtaatccgt aaagattttg aacaggactt
      181 ccgcgacaag attatttcca aatacgaagg ccatattccc tgcgaactgg tattccagtc
      241 catagatgac cttcctgaag gcttcacctg ccccgaaggc cgtaccaaac cttggggaac
      301 caaccatgct gtaatgatgg gtgccgatgt aataaaggaa ccgtttgctg ttatcaattg
      361 cgacgatttc tacggtcgtg actccttcca ggtaatgggc aaattccttg cagcccttcc
      421 cgaaggctcc aaaaacgtat attccatggt aggcttccgc atcggcaata cgttgagcga
      481 gagcggtacc gtatcccgtg gattgtgtgg aacggatgcg aacaacctgc tgacttccgt
      541 agtggaacgt accaagattc agcgcatgga cggtgaggtg aagtacatcg acgataacgg
      601 tgaatggact gccactcccg agacgactcc ggtcagcatg aacttctggg gtttcactcc
      661 cgattatttt gcttacagtg cagagttttt caagagtttc ttgagcgacc cgaagaatat
      721 ggagaacctg aaaagcgaat tcttcatccc gctgatggtg gataagctga ttaacgatgg
      781 cactgctacc tgcgaagtgc ttgatacaac cagcaagtgg ttcggtgtga cttatcccga
      841 agaccgtcag agtgtagtcg acaagattca ggctttggtg gatgcgggcg agtatcctgc
      901 gaagctgttc tgagtttgtt aaccaaaggc agatacccgt tggggcttat tctctgatta
      961 taatcggaca atagattcgc atgcctccgc tactgccgga tggtgggtga cgaagataca
     1021 tgttttgcct gcgcagtctc tgcgcaggtt ttttattaac agccgttccg tgtcggggtc
     1081 gagggcagaa gtggcttcat ctaaaagaag aatgtttccg gggcgtagca gagcgcgggc
     1141 aatggcgatg cgttgggctt gtccttcact gagtccacca cctcgttcgc tgagtgggga
     1201 gtctacgccg tcgggaaggt ggaagacgaa gtcggcggtg gcggtttgca gggcttgata
     1261 tatggcttct tgagaagctt gtgggtttcc catcagcagg ttgtcacgga tagttccgct
     1321 gaaaagggta ttgccttgcg ggacatatac gaagttcttg cgggtttgcg gagagacggt
     1381 atgactggtt tcaagtggat gtttggcggg tatcaagagt atctgtccct cttgtggcgt
     1441 tgccagtgcc aacaatagcc ggatgagcgt tgtctttcct tttcctgttt ctccgactat
     1501 agctatgcag ctaccggcgg ggaaacggca ggagaagcgg ctgaataccg gacggtcatc
     1561 gggagtgtag cgaaaagtca cgtctttcag ttccagttcc ggggtagagg cgaggaatat
     1621 gctgtcacca tccgcttctg ccggcagtct ttccaattcc aatagccggt ctatggcggt
     1681 aagggcattg actacggaag gtatcaggcg tgagaggtcg aacacgggac gctggacttt
     1741 tcctaccaat tgcaaaaagg cggtcatcgt tccgaaggtg atacagcctg cgctgaggtg
     1801 aacggctccc caaagaaaag ccgtgaggta tccgccggaa aaggcaaggg ccactaacat
     1861 gtgggcagaa agcgagaaac gggtacgtcc catgacttgg ctgtggagca tgtcttgcaa
     1921 gtcatcgagt ttgtccagat gccgttcgcc ttgttccaat gttttaatca ctatgcgatg
     1981 ttgcaggctc tcttgtatga cggactggat gcgaccgtca ctgttccgaa tatcatgtgt
     2041 atagcgtttc attcgtcgca tatagaaacg gctgcctgat agaaagacgg gcaggatggc
     2101 aacaatcagc catggcagtg aagggtctaa aaagtagaag aatagaaagg ctgccagcag
     2161 ttgtatactc gtgacgatga atgccgggac agaagaggtg agcaatgtga cgatggcggt
     2221 ggtgtcttgt tctacccggt tcactacgtc tccggtatgg aaacgctcca attcgttcca
     2281 gcggctttgc agtaagcgcg agaagaggcg gtggcgaagg gcgttgcccg tctctatctg
     2341 catacgggta cttatccaag tgtcagcagc tccgcacagt aattgggcag tcagcaggac
     2401 aacggtgaga acggcgatat gcgtcaggtt gtcgtctgtt attccggtag cggtgtctat
     2461 cacccgtttg gttgcataga taaaggctag ggcaaaggcc acgcccagaa tgccggtgag
     2521 gcaacttagc aggatacgtc cgcgttgttc ggcagatacc tctcgaatat acctaagttt
     2581 ttcacgtctg tcctttttca cttttttgtc cttctgttgc tttttcattc cttttatttt
     2641 ccgggttctt ttatttcttt gtccttgctt tcttgtcttt tactcctttt gatcggttta
     2701 tttgtatagc tatcgttccc cctatcagag tcacgggata ccagagtgct tcgtacggtg
     2761 caaattgacg cagttcgttg cagcgtcggg tggcgcggca gaaggtgtac cactttcctg
     2821 cccaatatcc tttggggcgt ggcttgatgc ggttatcatg ttgcccgaag ttaccggtag
     2881 acaggatgtc ttccaataat tgttctccta tctgcttggt gccttccaag gggaaaggaa
     2941 gccggttggc gggcaatccc agtcgggtga cggcaatgta gccgaatgct tgtgcggcat
     3001 gcaatagtcc gaggtcctgc aactggcgaa gcagggtggt ggcatctatt tctttgtggc
     3061 gattggcaag cagacaagtc cagtcgcata gctggcgcag gccgattccg ctgttcagga
     3121 aatgtacaaa ggcatgcagg aagatataaa gtgcattgaa gctggccgga ggtatggcga
     3181 tactgacggc cttcgagtcc tctttcccgg tttcggagaa tagggcatag tctgtttcct
     3241 gcgggtacca ttttctgata atctgctgaa agtaccggtt ggcaagcgga ctgttcagcc
     3301 ggaggatgat gcggtggttc tcgatgtgta ctcctttcaa actgtagctg gcatgcttgt
     3361 cggacgcttc tccctcgact atggcgcctt gttgcagcag gaggcgattg gctatgggtt
     3421 gcccttgttt tcctaaatag atgtcgatgt ctccgcattg ccggtgcaag ggagtgcggt
     3481 agttggtgcc gatgccttgc cctttcagca gtacgggatg cagcccggct tcccggtaaa
     3541 gggtattgag ttcgggcaga agctggttga ggcgtttgtt ggcttgttct atctgtgcag
     3601 tccgggcagc ccatttcaga tagaggacgc gtggagggcg cagttcggcc ggcagactgc
     3661 ttatgccgtc aaaagtcagt gcaagcaggg cttgtgagtt tgccatgcgg tacacggttt
     3721 cccagtcgtc cggcgagacc gaccggaaga gttgtcggtc tgccggagtg ccccacaggc
     3781 cggagcgtac caatgaaaag aaagcgtgtt gcatatccgt ccttattcta tgattccttc
     3841 gcggtcaagg gagtcgataa acttctgcgc atcgcgacgg gccgattcgt tatctacatc
     3901 atagcggctg gtcagggctt ctgtcacgct gtctgtatcg aactctttgt tttctatctc
     3961 ttgccaaagc atggcggaag tttggttcag gctgatgact ttgctgaagt ccacgttcga
     4021 cgagccgtct tgcatgatga tgtagtcatc gcctatccgg tgcaggataa atccttgttt
     4081 gattttcatg gttattttgt tttatattct tctgaacagg gcgagcagcc agcggcgagc
     4141 ggggtttagc ttcatccacc agtaggagta gagcttccag actttgccgt cggcggtgta
     4201 ccgtttgtct tttcgcatgg cttcggtcat gacgcccatt acccgtccga tgtcggtttc
     4261 ttcggtctgg gcgaggttgc cgtcgccttg caggatgagt atgtctccgt tccgacggat
     4321 gatgcggtga aagacgatgc gttccgtcag gtcgcgtgcc agtacggtga cgcccggttg
     4381 cagctgttct gtggtgaaat cgcccagtgt cacccggtca cggcggtcca ctaagaaagg
     4441 attcatgctg ttgccccgca cggtgatggt tactgtatgt ccctctttga tgagacgcgc
     4501 cacttcggga agcaatatct cgttgggaat gcttttcttc atcggctgtt cagttcatca
     4561 ttcataactt atccttctac cgtctttctg caaagttccg tcgcttcacg gtcgggtagg
     4621 catttcagat gatagacggg tgccagcgtg gcaagttccg tcacagtggc gacaatggcg
     4681 ttatagattt ccttgttctg ctttaggcaa gagcaggagg ggaggagggt ggcgaaagca
     4741 tgtgctgctc tctcttgctc tatttcattc tgcggtgctt gttccaagcg gacgaaggcg
     4801 cctacggtca tggattcttt ccgatagcaa ggtgtctttc cgctccacgg agaaccgaaa
     4861 acagtggctt gcttgccgag gctgtccaca tgtactatcg gattgtcatc gttcagtaga
     4921 tggcagtccg agaactgttg cagccagagc ccggtgtgcg tacttttgcc cgtgccgctt
     4981 ttccctaaga agaggtagcc tttgcctgtt tcagtagcga caaccgaggc atgcatcagc
     5041 agtgtatggt ggcgggcggc attgaaggca tagagcatca tcaagaagtt gttcagtacg
     5101 aagttcgttt cgttttccgg aaccggtgtt tctgtcctgc aggccggtag gtggatgaag
     5161 cattgcctga agttatcgtt gcactccatc caatagtttt tcccgctttt ccgtggggtg
     5221 atggatacaa ggtgtgagct gtggggcaaa gggcgaatga tgcaatcggc atcttcccag
     5281 ttgaaacata tatcatcggg agttttcgct atggttcgtt ttgtcgttgt ttcgtcatcg
     5341 tctatctctg tttcaaagat tactttttgc gtcgtgtcta ttgtcgtgat gaacggaatc
     5401 agtgaaggca gcgccttgaa tatattgaag tcggaaggtt tcaccatgcg aaaggtgtgc
     5461 ggtcctactt gataatccaa tatctgtatt ctcatatgtt ttgattgtta gttgttattc
     5521 atgatacttt gggctactca gaaaaataat gaatgtttgt gtgaatgagg aagatttgag
     5581 agatttttca actgtcttgt tgtcattctt tagacgcgga ggacgcagat ctataaaaga
     5641 aaatccgctg tccgccgcat ctaaaagata gtaataaggc gattccgata tctcttcgtt
     5701 tggtttgcga ggatatattg cttcctttct tagaatttgg cttatcggtt ctcctgactt
     5761 gtttggccaa caatatattc tttcctccca tcaccgactt tgtgggctgc tgtatataca
     5821 ctgccgtcac gggtaacctc gtagcctgtt accaaatagg actcattgtc gtccatattc
     5881 ggatttgccg ggttgaaatt gatgaacgtt ccaccggaca cctggatgct ggcagtgttc
     5941 ttgtctgtat tctttaagtt cagtacccag tatctgccat ccgtgtcgtt gttgggtgta
     6001 ccatatttgc cggattcaaa tgttcctcca tagatattga ttttcccatt ctctcttgca
     6061 taaatcaggt ctatctgggt gttcagtttc tgggtgttat agtaagaacc gccatgaata
     6121 tttactgtcc cgtatcctcg ggcttcaatt accatgcgat aaccatcgtc tttcgctgta
     6181 gcagatgcat cgcacttcac attgccgttg cctgaaatgt ttagtgttcc gttctgtaca
     6241 gtaaagattt gtgtgaaagg agtggcatca gctgtttctg aggaattgat gatgtcgtgg
     6301 ccattcaggt ttaagtttgc cgttgcgttt gcagcattca atatgtagcc tgtggcaagc
     6361 tccgtcttgg cgatgttgat atttgagaga agttttatat ccacagttgc gttggttgcc
     6421 atgtacttca gtacgcttgg gtcggagaat gtaccgccgg aaacagagat gatactttgg
     6481 gcattttcgg ttcccacgga tgcatctacc tttaagtcac cgttgaaagt accgcttgtg
     6541 atattcagct tcataagttc ggtatttcct gcactcttgg aaatttccac ttttccattg
     6601 atgacgctcg taccgcttac cgtaaccgtg actccagcag tgtactttgc atagccgcat
     6661 acgtcgaatg caaattgatt cgcattgctt cctgcgttga tagtggtatt gttgatgctt
     6721 atgttgccac aattgttgct tactacgtat tgggcatttg tgtcttctac tgtcatatta
     6781 tctaatgtca ggttgcagta gttctgaatc atgattttgt tgttgtcact cttcagcgtt
     6841 ccgttcttga aagtaacgtt tgaaccttcg agtaattgac agctgttcgt ttcggtgccg
     6901 gtggaaccta cggtcgggtc agcaagtgta agaatcttgc cgcctaagtc catcgtcaag
     6961 gtttgtccgc ttgtggtctt gaatcccggg caggtcttgt cggcggtcaa ctttatgttc
     7021 acatttgcat ttgccttcat gtacttcagc gcgcttgggt cggagaatgt accgccggta
     7081 acgttgatga ccggtgtata agtggtgcct tctgtgatga gtgactttgc ttcggcaatc
     7141 agtgtaccgc ctttgatgtt tactgtggca atgccatatg ctccacttac gttgatggcg
     7201 gcgcagtcca gtcctccggt accgtcgccc cagttgccgg tgctacctgt gcctttactg
     7261 gtaatcaagg ctgtaccttc cacattcaga gtgcctcgtt ggatgcatac acctcctgcg
     7321 gcaccataaa ccttgccgcc actgatggtc gttgtgccgg attggggcag atagactgca
     7381 tagtcagcag tagaaatgag ttctccgtct gtgatgttga tgatggagtt ctgcgtcttg
     7441 taattgccgt tgcctgccac tgcaaaccat ccggcttcta tcttgccgcc tgtcatggtg
     7501 aagtctccac cgtccgtcac tccgacgcca tattggccgt tactgtccgg agtctctctg
     7561 actgcactga tgttgccgct ttccatggtc atggaggcat cttcaccggc tatttcaatc
     7621 agactgccat tataagaagc cgctgtataa tcctggctgg caactatctt gcctttcttc
     7681 tcggtagagc tgtccttcag tgtcatcttg cccaagacga tgattttgcc tgttgcgctg
     7741 ttgtcggcag tcagtgtata tccgttcaag tcaagaacca cggactttcc ggcgggtaca
     7801 ctgacgcttt gccctgtgat gtcggcatcg gcggacaatt taaaatcttc gccgttggcg
     7861 aaagcggtct ttaggactgc cacgtcggat tgaactacaa atttgctgtc gattgttgcc
     7921 ggaagtgatg cttcagttcc ttttattata tagattgtgg tattgccggc atcgtgtacc
     7981 aattgttcta cctttccata tatcttcaag ttaccgcctt ttacagtcag cttctttacg
     8041 gtgacgcctg cattgataat caatgtctgc tgggcggtag tggcagtcac ttcattgtaa
     8101 gtggctttat tgcctactgc tgccaatgta acggtggtgc ttggcatggt gatggctaca
     8161 gaaggagctt cttgctctgc tgtggtttcc ggtacagcca aggatacact gttggtggca
     8221 gtggcggcgg gagcacttac gctggtattg gtcttgtcgg tcagcgtcaa cggagcggca
     8281 gtactggtcg ttggggctgt attgaacgtc aggttgatgt ccgagttctg taaaaccggg
     8341 atggcgatgc cgtcgttgct gccagaagtg gtattgaagc tgccgctgac tgcaatgtcg
     8401 gttacagttg ctgctgtcgg tgcttcttgt gggagatttt ttgaatcagc taaagctgta
     8461 ctaagcgcac tgggggttgt agcatctaca acaacgcaat ccaaaggagg tactaccaat
     8521 atgtctcttc tccctaagat tttgtcatta agcgtcttgg taaaatatac cttgtcgctt
     8581 ccattcgtca gttgggcagt gatggaacta taagtacctg tgggcaaagg aatgtagaag
     8641 ttgcgcgatt ttatatcgtt tgaagcagtg aaggaggcag tgatttcctt gcttccattg
     8701 cttgctaccg tcagtatcgg gtctgctgcg gttaagtcta ccgtacaagt acctgcaatg
     8761 ttattggagg caataatctt gaaagtagtg gcctctgccg gaatcttgtt gacggtcagt
     8821 tttatcatgg ctgccatgtg cttgaaggac agagcgctca gattgtcggg atttgtcacc
     8881 ttggcataca tcgggccatt gctgctgccg ttataatttg taagcgtggc aggtagagtc
     8941 atggtcaatg tattgccgct tacgctcatg ttttgttggt aaggatagat ggagaataca
     9001 gccgtttctc cgcttggctt gctgccgttg aaagtggcgg aagtttgacc agcaccgctt
     9061 gcatattcta attttgtatt gctataatta ctttctgcat tactacagaa caaccctagg
     9121 gcatcggtat cttgccatag aatcttgtat tcatcgttta cggtagtacg ggtgtcggta
     9181 cctgcgcctt caaacgttgc gttaacggtg atgtttcctt tccgcccgct gttttcaaat
     9241 tcctcttggc tgcaactgaa tgcggtcaag gcagcagttg ccatgcaggc aacttgcata
     9301 aggtttctta atttcatcat aatgaagtcc cccttagttt tctacggtta agatgtcatt
     9361 gattaggtct tccaagtcgc tgctggatgc cgaattgtag ctatgggtag aagtgctgcc
     9421 cgaataggag cgcgtaatgg gatggtaagg ttcgccgctt gttgcaatga ctccttcatt
     9481 ctccattttg ataacttcga tagacggagt gatgtatgct tctctaccgt ctggtgtgtt
     9541 ctgtttcata tacacaaatt atttaaaggt taaacaataa aaaaaacgtg agtaactatg
     9601 tttgtatatc ctttattcag gccttcgcat tgccttacag atgaatatac aacagtcacc
     9661 cacgtcgttt gtgtatatac catccccctg atgggagaaa accatataaa catagacgtg
     9721 agcatccttg ttgttatctt catctgtaat tttcaaagtt gcgaagtttg aataaagaag
     9781 ataatttcaa taatgctctt actaatatgt aaataaaccc actacgctat agcggatttg
     9841 tgacaaagat aattgttttt tgtttaagtg tatctatgtt tctctatttt ttttgggaaa
     9901 ggctcacgtc tctttcattt ataggagtta ggagagttat cacttctaac tcccgataac
     9961 tccttcaaat atttagtaac tgtctgcatt gtctttgagg atgtttttct gaggagcata
    10021 gcggctatgt ggcgaataaa gaggggaaga cagaccgaaa agaagctgaa taaaatcttt
    10081 ttaagcaaaa ttaaaacaga gatttgatat actttaaaca gaacaccctg caaactccgg
    10141 cttgctctgt ccggcagttt gcagggtggc tgcttggttt tctcgcgtgt acgtagctcc
    10201 ttacgccacg aacggaagtc gatgccatag caatttttca taataagact ttccatattt
    10261 ttgcaaatgt ccgtactgcc tttggctgaa acaatttata taagtaattg aagtttcgta
    10321 agtgagtatg cctgctgata aatgggaatt tatcgcacag agcgcgaagc ctgctctcat
    10381 aacctatgga gagcacgagt gaaagcttgt ggatttttat ctaaaacata ggtattcctt
    10441 tgctcttctc cctttgtttg tctgctgtgg catagggaat ttatgacgcc taacggccat
    10501 gaacaaccct gctttcggcc ataaagcgat cgcttgacga ccgtaagcag ggttgttcat
    10561 ggccgttagg cgtcactaac tccagagcta ttgcggatga agtacgtagt ccgaacctat
    10621 tgcgcacaag gcgcaaacgt attatacaac ggtgtaaaag acattagagt gcattattca
    10681 tagtcggcct ttgactcccg ataactccta ctatgcccct acagtccaac tccatatctg
    10741 ttgacttcac agtaaggaca agcccgaaaa tgcaggaaaa ccgaacctgc cgattcatgt
    10801 aatctgcatg cagtattatg ctaggggata gcagcttact gcaaaactca ggcgtttcag
    10861 gcaggtggaa gcaaattttg cttccacctt ttcaggttgc ttccaccgca gggcaaatgc
    10921 cgatggacag ggggatgcag gaggtgggtg gaagtgtgga agcaaagtga tggaaaatta
    10981 atttggcatt cacacaataa taaccgtata tttgtagcat ggctgtctgc ctcctcttaa
    11041 attcagataa agaggaggta gacaaatgct tgctatgaga aacacataaa tggttataac
    11101 caagtgatga aacaattaat tgcatgttgc ggactggatt gcgaaaattg cgccgcccgt
    11161 atagccactg tcaataatga cgatgagctg agagagaaaa ccgccaaaga gtggagtgtg
    11221 ctgaacaata cgccggaaat tacggcggaa accatccatt gtatggggtg ccgtgcagac
    11281 ggggtgaagt ttacctattg cagcgattat tgtgctatcc gcaaatgtgt gtacgaaaaa
    11341 ggtttcaata cttgtggcga ctgtaaggaa ctggatactt gccaggtggt aggtgcggtt
    11401 cttcagcatg cgcccggtgc aagggaaaat ctttattaac cgtaaaatct ttgattaaat
    11461 aaaatattgc ttatctttgc agtatgacaa agacatttaa atcggatttg gttttgtaaa
    11521 caatctgtgt tccatgcaca gattgtcccc tttcgtttac tttcggataa cttctttcga
    11581 gagtgttttt ctattgttat aattcaagtt taatccgcat attatgctga aggtgttgtg
    11641 atactttccg tatatgcaaa atatagtaag aaaatgagta acgaaaataa aactatccac
    11701 gatttcgaat ttaatttaat ctgtgacttt ttctccaata tggaacggca aggccctggc
    11761 agtcctgaag tgacgttgaa ggcattgagc tttgtagacg gtcttaccga tgaatccctt
    11821 attgccgata tcggttgtgg aacgggtggt cagacaatgg tattggctgg ccatgttccg
    11881 ggacagatta ccggaattga ccttttcccc ggctttattg acatcttcaa ccgtaatgca
    11941 aggcagttgg gcttgcagga cagagtaaaa ggaattgtcg gttcaatgga tgccctccct
    12001 ttcggtgagg aggagctgga tatgatttgg tgtgaaggtg ctatctataa catcggcttt
    12061 gaacgtggct tgaaggagtg gcgtaaatat ctgaaaccgg gagggtatat tgccgtatcc
    12121 gagagttcat ggtttacgga cgaacgtcct gcggaaatca atgacttctg gatggacgcc
    12181 tattctgaaa tggatacact tcccaatcag gtgaccaagt tgtacaaggc aggttatctt
    12241 cccgttgcta cattcatttt gccggagaat tgctggacag agcattactt tgcttcaaag
    12301 gttgcggctc aggagatttt ccgtaagaaa tatgccggta ataaaattgc cgaagagttc
    12361 agcttactcc aaatgattga ggatgaactg tacggcaagt ataaggaatt ttacggttat
    12421 gtgttcttta ttgccaagaa ggtaggctga tgacggactt ctcttattga ggaatgcggg
    12481 tattctcagg acagaatatc cgcattttgg gttttgagta gattttattg ttttgaggat
    12541 gtacggaact tctgaggagg tattcccgta tgacgtttaa agaatttgtt gaagaaggcc
    12601 gcattattaa aacctagact cacggctata tcctttatcg gagtgttggc ggtacaaagt
    12661 tgtgctttgg catccatgat gatagtattg ttgatgattt ccatggctgt atatccttat
    12721 tcctttttga caaggcggca aagagctgcc ggtctcatat tcattttcaa tgcataatag
    12781 gacacttgat gctcccggac atagtctgtg tgtaccaatc ggataaaaat gcggtattgg
    12841 ttgaaatgcc tgctgcccgg agtctctttt attctagggc gttccggaca gagttcggat
    12901 ataccttgta acagataggt cagtagagtt tgcaatgaaa ctagacttga ggggctttct
    12961 gttctttggt agaggtgtga caaataggtc atgaactcgg cataaagctg gaagtccgtt
    13021 ttcgatagag gaaaaatata gtgtttgcct ataatgtgaa acttatccat catgaccttg
    13081 ccggcccctg aactctggat aagttgttgg gaaaatatga cgacatatat ttcagcatcg
    13141 tctgacgtgt gtagcaattg tacgaaggtc tcgggaggaa taactaggag ggcgttagct
    13201 tcaaccctga attgagtatg gtttatgata gttttcagaa ctcctttggt gcatagagcg
    13261 aagatactgg ccttggtgtg gtatggcttt tccactagcg gattcagttc attggttgtg
    13321 atatgattgc aggcaatgaa ctcgtcattt atattgaatt cggatatatt catgttggag
    13381 attttaagac gcaaaaatgg gggataataa tgtataaatg acagaggtaa cagttaaaat
    13441 caatattacg ctcaacttat ctctgttaaa taaggtaaag ttgtgaataa tagaatatat
    13501 acatattaaa atggaatatt gatttataag ggtttgtttg tggtataagc attttaaccc
    13561 gaactttgct tcttgtatga taaaccaatt ctgatgaatc cgaatgttcc tcaagaagta
    13621 cgtataataa atgccatctc cgagcagttg ttcaactcat ggcccgtcag cattattatg
    13681 attgatttgg aagattgtat ctggcgtctg aatcagcagg tgatgaatga actccaattg
    13741 aatgagtatg tgatagggcg gcgtatcact gacttattgg aggtggtatg tgataaaaag
    13801 aatgtgttag aagacctttt gctgcaactt cgggagaggg atgtgcggat tattccctta
    13861 gataccaatt gctttatacg tgaattgaag agtggtatca gttttctgat acaaggtgct
    13921 atggtgggaa ttcatgaaga tggacaattg gtgaggattg tactctattt caggaatgtg
    13981 ttggaagaac ggacacagaa gcatttgctg aatattgcgc tgagtcgtac ccagatattt
    14041 caatggtctt tcgacatgga acataatctg atgattatag aaccgcgtt
//
