LOCUS       c00011_gnlPro..        12396 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIIIGFFF_11.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:51:26
            Original ID  :: gnl|Prokka|CIIIGFFF_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12396
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..789
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_1"
                     /sec_met_domain="EC1_2-faecali (E-value: 1.1e-91, bitscore:
                     296.1, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TMGFIDYEVDGQVGIITINRPKALNALNSEVLKDLDATIDAVDLD
                     AIRCLIITGAGEKSFVAGADIGEMSTLTKAEGEAFGKAGNDVFRKIETLPIPVIAAING
                     FALGGGCEISMSCDIRLCSENAVFGQPEVGLGITPGFGGTQRLARIVGPGKAKQLIYTA
                     RNIKAAEAYRIGLVNEVYPLEELMPQAKKMAKGIAKNAPIAVRACKKAINEGLEVGMDE
                     AIVIEEKLFGSCFETEDQKYGMAFFLDKNKEKVKEPFKNC"
     protocluster    1..12396
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4810]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4810
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..12396
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12396
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             859..1698
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_2"
                     /sec_met_domain="HCDH (E-value: 7e-39, bitscore: 122.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 6e-62, bitscore: 198.3,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGSGIAQAFAQTEGYEVYLCDINDEFAANGKKKIA
                     KGFEKRVARGKMDQAKADAILAKITTGTKDICTDADLVVEAALEVMEVKQQTFKELQDI
                     VPATCMFATNTSSLSITQIGAGLDRPVIGMHFFNPAPVMKLIEVIAGLNTPDEMVEKIK
                     AISVEIGKTPVQVEEAAGFVVNRILIPMINEAVGIYADGVASVEGIDTAMKLGANHPMG
                     PLALGDLVGLDICLAIMEVLYNETGDPKYRPHPLLRKMVRGGKLGQKTGIGFYDYSK"
     CDS             1799..2953
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_3"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.4e-52, bitscore:
                     167.5, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.3e-31, bitscore:
                     96.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-41, bitscore:
                     131.3, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKKHEMARQLFKEFAENEVKPLAQEVDETEHFPEETVAKM
                     QKLGFMGIPVPKEYGGQGCDPLTYIMCVEELSKVCGTTGVIVSAHTSLCADPILTYGTE
                     EQKQKYLVPLAKGEKLGAFGLTEPGAGTDAQGVQTKAVLDGDEWVLNGSKCFITNGSYA
                     DYYIIIAITSVDTDARGRKKKKFSAFIVEKGTPGFTFGTKEKKMGIRGSATYELIFQDC
                     RIPKENLLGPMGKGFAIAMHTLDGGRIGIAAQALGIAEGALDATIAYVKERKQFGRAIA
                     AQQNTQFQLANMATQVEAAKLLVYKAAMAKATQRVYSVEAAKAKLFAAETAMDVTTKCV
                     QLLGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGNLLR"
     CDS             2968..3753
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 163.8;
                     E-value: 1.3e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_4"
                     /sec_met_domain="ETF (E-value: 2.3e-51, bitscore: 163.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKIVVCIKQVPDTKGGVKFKPDGTLDRAAMLTIMNPDDKAGLEAA
                     LRIKDETGAEVTVVTMGLPKAEEVLREAMAMGADKGILVTDRVLGGADTWATSTTIAGA
                     LRNIDYDLIITGRQAIDGDTAQVGPQIAEHLDLPLISYAQDIKVEGDSVIVQRQYDDRY
                     HVLKAKMPCVITALSELNEPRYMTPGGIFDAYDAEITTWGRKDLKDVDDSNLGLAGSPT
                     QIAKASDKVRKGKGVMMTAETAEEGVEYIMDKLLTKHVI"
     CDS             3743..4810
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 166.4;
                     E-value: 2e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_5"
                     /sec_met_domain="ETF (E-value: 3.6e-52, bitscore: 166.4,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 6.7e-39, bitscore:
                     121.5, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSNCKGNVVNRMNLEQYKGVFIYAQQVDNKIDAIALELLGKAND
                     LAADLGTDVTAVLIGSGVKGLVDELAEYGADKVIVVDDPELKEYRTEPYTHALASVINE
                     YKPDILLVGATAIGRDLGPRVSARVATGLTADCTVLEIGEFKARGDKEPRQGQLLMTRP
                     AFGGNTIATIACPNHRPQMATVRPGVMQKKEPVAGAKAEVIEYNPGFTPNDKYVEILDI
                     VKSVTETVDIQAAKILVSGGRGVGSAENFALLDDLAEALGGTVSCSRAVVDNGWKPKDL
                     QVGQTGKTVRPNVYFAIGISGAIQHVAGMEESDIIIAINKDPDAPIFDVADYGIVGDAL
                     KIVPKLTEAIKAQVK"
     CDS             5422..5712
                     /locus_tag="ctg11_6"
                     /transl_table=11
                     /translation="MAQIIASTKEISNKRESLIVLSNSLKNKISLLETLGNSLNSMWEG
                     AAKEKYVKQLKTDISKMRNLLKTILEFILILEKIIAIYNKAEKKNEATAVS"
     CDS             5724..6041
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MADLINVTPEKLKATASSFQQAGKDVKKTTSDMLQLVRGISSSIW
                     SGEASSIYLGKFNGLDADIAKMCKMIEEESQHLTTIAQEYQLAEEQNKQVAATLKNNVI
                     A"
     CDS             6066..6782
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MLSVMIFCHDKREGDLIGKICNQCVALIDKEFLRNFIISDEEYHQ
                     VNIEGIQPPDLLVVEITGIEDLCRAKRIRGIFPRGRLLVVSTNQISAEYYLIPEVSPDM
                     LLLKPYVYAKACKIIHRSLTWCCKDKCRKKKQEDILKIRTGGEIYYFHYEEIQYLEARD
                     KKIILHVNKYEISFYSSLQKLEKSLPDYFIRCHRSYIVNFMFIQKADLINGEFYLNKKT
                     VIPISQKYKAKLAKML"
     CDS             6891..8231
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hyd_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AcetylCoA_hydro"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_9"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 6.8e-64,
                     bitscore: 204.0, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 8.6e-31,
                     bitscore: 97.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFIKEYAQKLVTAEEAVKVVKSHDWVDYGWTTGTPVALDAALAA
                     RADELEDVKIRGGILLREPEIFKVNNVADHFTWNSWHMGGLERKAISKGFAYYSPLKYS
                     ELPRYYRENIKHLNVAMFQVAPMDKHGFFNFGPNASHMMAVCEAADVIIVEVNENMPRC
                     LGGFEEGIHVSRVDYIVEGENPAIGELGAGAPPTEVDKAVAQLIVEEIPDGACLQLGIG
                     GMPNTVGSMIAESDLKDLGVHTEMYVDAFVDIAKAGKITGLKKNIDRGRQVYAFGAGTK
                     KMYDYLDDNPECMSAPVDYTNSAKTIAQIDNFISINNAVDIDLYGQVNAESAGIKQISG
                     AGGQLDFVQGAYLSKGGKSFICCSSTFTSRDGVKHTRIRPTLAEGSTVTDTRPNTHYVV
                     TEFGKVCLKGMSTWERAEALINIAHPDFRDELIKEAEKMHIWRRSNK"
     CDS             complement(8529..9557)
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MIAKDDIVIRKAILHILDTNRGECILSNTLLDPGPDLHDFIRNHI
                     YKIVSSDDTKNCEFDPEYSPIYSILETWDESDETSFIETSQAIANKLYIAMGEGLDIPA
                     ADLLFVTFQAEGIIYLALLKMNYKESYTHEVTETPDNPVINTDIIKTHSLLPSATSRIP
                     EAVVINLSNYHIKLLEKKYEINGEKAYYLSENFLVCRTSIPPKKKLNILTRVINNISNK
                     YDGADLKTKMDTKSALQKEYVDNKSFDIEEIGNKLFGKSPEKKSEFDEKMEQYDLQYDN
                     FTVTNESTVKKLEKQVMVTDSGIEISIPMETYNKLANFEVQTDVTGKSTIIIRNIDNLV
                     LK"
     CDS             9619..12396
                     /locus_tag="ctg11_11"
                     /transl_table=11
                     /translation="MRFLIFIYGKSRMKRTQLVSGKRAECHILLPKDDFSLERTVFLQF
                     KNISGEWFIKETDCCHLKTEEFFQMGKRKSDEGIFYKLSIGRKNELSVGGKDLYIQLIR
                     YRNDWSIYKKYKLRDCRIIKEKNIFIMMEKAINRKNSMGISYEYGKWFIEKCGNIEIYI
                     NEILLEKKQQLEFGDVICIGTIYLLFFENYIAVEAGERNIVSDYLEEVILENEIKGQED
                     VRKKEKREITFHRAPRVMEELKKVSLKVDAPPQVDVQEKKSIFMDIGTIMNLMFPMLGM
                     NLFLIYGMKSEQNQAGIYVYSGLFMAVMSAVCSILWLMISRKYEKREQQKKVNKERLAY
                     RRYLNKKSEYIKVQYERVYKVLQSRYLRADTYLDSPLLDMYLWNRNLYHKDFLMYRIGI
                     GDVEFPMKIEFPEEVFGDEENILWREAKKIKEHYEILHQIPVLLDMGRYSQIGIITKDT
                     IAGMELVRSIILQIALCNCYTEVKIGCIYNKNKVIQSQQWDFCRWLPHIWDANRQKRFI
                     AGNEVEARRLFYDLLQIFKEREEVSISDKSEKILPHYILFVAEEQFLEGEMFSKYILDR
                     GKEYGLTVVWLDSMRKKLPNTCKMVLEINGGFTGRYEIERHSQKKEKINFDYTEKNIAE
                     KLIRSISGIKVMEIEEKAGIPEVVDFLGMYDVHTIEELHIKQRWEKNRIFESAKVLIGK
                     KAGDEPFYLDIHERYHGPHGLLAGTTGSGKSEVLQTFILSMAVNFSPEAVCFLLIDYKG
                     EGMSALFSELPHISGKISNLSDGQAYRAMVSIKSENKRRQRIFKECKVNNINDYTRLFN
                     SGSVNEPIPHLLIIIDEFAELKKAEPEFMQELISVAQVGRSLGVHLLLATQKPGGVVDD
                     KIWSNSRFRICLKVQEREDSMDMLHNMDACQITQTGRGYLQVGNNEVYELFQAGW"
ORIGIN
        1 acaatgggat ttatcgatta tgaagtagat ggtcaggttg gtattatcac catcaatcgt
       61 ccaaaggctt taaatgcttt aaacagtgaa gtattaaaag atttagatgc aactattgat
      121 gcagtagatt tagacgcaat cagatgtctt atcattactg gtgctggaga gaaatctttc
      181 gtagcaggtg ctgatatcgg agagatgagt acacttacaa aagcagaagg cgaagctttc
      241 ggtaaagctg gtaatgatgt attcagaaag attgaaacac ttccaatccc tgttatcgca
      301 gcaatcaacg gattcgcttt aggcggtggc tgtgagattt ctatgagctg tgacatcaga
      361 ctttgctctg agaatgcagt gtttggacag ccagaagttg gtcttggaat tacacctggt
      421 tttggtggaa cacagagact tgctcgtatc gtaggacctg gaaaagcaaa acagttaatc
      481 tatactgctc gcaatattaa agcagcagaa gcttacagaa tcggtctggt taacgaagtt
      541 tatccactcg aagagttaat gcctcaggct aagaagatgg caaagggtat tgcaaagaac
      601 gcacctatcg cagttcgtgc atgtaagaaa gctatcaacg aaggtttaga agtaggaatg
      661 gatgaagcta tcgtaatcga agagaagtta tttggcagct gcttcgagac agaagaccag
      721 aaatacggaa tggcattctt ccttgacaaa aacaaagaaa aagtaaaaga gccatttaaa
      781 aactgctaat taatctatta catatattga taatattaat tgtcagaaga taatacattt
      841 tataggaggt ttcagacaat gaaagttgga gttattggcg caggtacaat gggatcaggt
      901 attgctcagg cattcgcaca gacagaagga tacgaagtat acttatgtga tattaacgat
      961 gaatttgccg caaacggtaa aaagaaaatc gctaaaggat ttgaaaagag agtagcaaga
     1021 ggaaaaatgg atcaggctaa agctgatgca atccttgcta agattactac tggtacaaaa
     1081 gatatctgta cagatgcaga tttagtagta gaggcagctc ttgaggttat ggaagttaaa
     1141 cagcagacat ttaaagaatt acaggatatc gttcctgcaa catgtatgtt tgcaacaaat
     1201 acctcttctt tatctattac acagatcggt gcaggacttg acagaccagt tatcggaatg
     1261 catttcttca acccagctcc agttatgaaa ttaattgaag ttatcgctgg tcttaataca
     1321 ccagatgaaa tggttgaaaa gattaaagct atttctgtag aaatcggcaa aacacctgta
     1381 caggtagaag aagctgcagg attcgtagtt aacagaatct taatcccaat gatcaacgaa
     1441 gcagttggca tttatgctga tggtgttgct tctgttgaag gtatcgacac agctatgaag
     1501 ttaggtgcta accatccaat gggacctctc gctttaggcg atttagttgg tcttgatatc
     1561 tgccttgcaa tcatggaagt attatacaat gagacaggag atcctaagta tcgtccacat
     1621 ccattattaa gaaagatggt tcgtggtgga aaattaggtc agaagactgg tattggattc
     1681 tacgattaca gcaaataatt aaaaaagtga atacggccgt ggggactatg ctctgcgtct
     1741 ccacggcttt taaggtggtt ctccacccca ataaccaatt tattatggag gaatgaaaat
     1801 ggatttcaca ttaagcaaaa agcatgaaat ggctagacag ctctttaaag agttcgctga
     1861 aaacgaagtt aaacctcttg ctcaggaggt tgacgagaca gaacattttc cagaagaaac
     1921 cgttgcaaaa atgcaaaaat taggtttcat gggaattcct gtgccaaaag aatatggcgg
     1981 acagggctgt gatcctttaa catacattat gtgtgttgaa gagttatcta aagtttgtgg
     2041 tacaacaggt gttattgtat ccgcacatac atcattatgt gcagatccaa ttcttactta
     2101 tggtactgaa gaacagaaac agaaatatct tgttccactt gcaaagggtg aaaagttagg
     2161 tgctttcggt cttacagagc caggtgctgg tactgacgct cagggtgttc agacaaaggc
     2221 tgttttagat ggtgacgaat gggtattaaa tggatctaaa tgtttcatca ctaatggttc
     2281 ttatgctgat tactatatta tcatcgctat cacaagtgtt gatacagatg caagaggaag
     2341 aaagaaaaag aaattctccg catttatcgt agaaaaagga actccaggat ttacatttgg
     2401 tacaaaagaa aagaaaatgg gtatccgtgg ttcagctaca tatgaattga ttttccagga
     2461 ttgtcgtatt cctaaagaaa atcttcttgg acctatgggc aaaggtttcg caatcgctat
     2521 gcacacatta gatggtggac gtatcggtat tgcagctcag gctcttggta tcgcagaagg
     2581 tgctttagat gctacaattg cttatgttaa agaaagaaaa cagtttggca gagcaattgc
     2641 tgcacagcag aatacacagt tccagcttgc taatatggct acacaggtag aagctgctaa
     2701 gttacttgtt tataaagcag caatggcaaa agcaacacag agagtatact ccgtagaagc
     2761 tgcaaaagct aaattatttg cagcagaaac agctatggat gtaacaacta agtgtgttca
     2821 gttacttggt ggttatggtt acatcagaga gtacgacgta gaacgtatga tgcgtgatgc
     2881 taagatcaca gaaatctacg aaggaacatc agaagttcag cgtatggtta tttctggtaa
     2941 cttattaaga taaggaggga aaatactgtg aaaatcgtag tatgtattaa acaggtacct
     3001 gatacaaaag gtggagttaa gtttaaacca gacggaactc ttgatagagc agctatgctt
     3061 actatcatga atccagatga taaggcaggt cttgaagctg cccttagaat aaaagatgaa
     3121 acaggcgcag aagtaacagt agttactatg ggtcttccaa aagcagaaga agttctgcgt
     3181 gaagctatgg caatgggtgc tgacaagggt atccttgtaa cagaccgtgt tttaggtgga
     3241 gctgatacat gggcaacatc tacaacaatc gctggagcac ttagaaatat tgattatgat
     3301 ttaatcatca caggtcgtca ggctatcgat ggtgatactg ctcaggtagg acctcagatt
     3361 gctgaacact tagatcttcc tttaatttcc tatgctcagg atatcaaagt tgaaggtgac
     3421 agtgtaatcg ttcagagaca gtatgacgac agatatcatg ttttaaaagc taaaatgcca
     3481 tgtgttatca cagcactttc cgaattaaat gagccacgtt atatgactcc aggcggaatc
     3541 tttgatgcat atgatgcaga aattactaca tggggaagaa aagaccttaa agatgttgat
     3601 gacagcaact taggtcttgc aggttctcca actcagatcg caaaagcttc tgataaggta
     3661 cgtaaaggta aaggtgtcat gatgacagct gaaacagcag aagaaggcgt tgagtacatc
     3721 atggacaaac tgttaacaaa gcatgttatc taattgtaaa ggaaatgtgg tgaatagaat
     3781 gaatttagaa caatataaag gtgtatttat ctatgctcag caggttgaca ataagattga
     3841 tgccattgct ttagaattac ttggaaaagc aaatgacctt gctgcagatt taggaacaga
     3901 cgtaacagca gttttaatcg gttctggcgt aaaaggctta gttgatgaac ttgctgaata
     3961 cggcgcagat aaagttatcg tagttgatga ccctgaatta aaagaataca gaacagagcc
     4021 atatacacat gcactggcat ctgttatcaa cgaatacaaa ccggacattc ttctggttgg
     4081 agcaacagca attggtcgtg acttaggacc tcgtgtttct gcaagagttg caacaggtct
     4141 tacagcagac tgtactgttc ttgaaattgg tgaattcaaa gctcgtggag ataaagaacc
     4201 tcgtcagggt cagttattaa tgactcgtcc tgcattcggt ggtaacacaa tcgctacaat
     4261 cgcttgtcct aaccatcgtc cacagatggc tacagttcgt cctggtgtta tgcagaagaa
     4321 agagcctgtt gcaggtgcaa aggcagaagt tattgagtac aatccaggat ttactccaaa
     4381 tgacaaatat gttgagattc ttgacattgt aaaatctgtt acagaaacag ttgatatcca
     4441 ggctgctaag attcttgtat ctggcggacg tggagttggc tctgctgaaa actttgcatt
     4501 attagacgat ttagcagagg cacttggcgg aacagtttcc tgttctcgtg cagttgttga
     4561 taacggatgg aaaccaaaag atttacaggt tggccagact ggtaagacag ttcgtcctaa
     4621 tgtttatttt gcaatcggta tttccggagc tatccagcac gtagctggta tggaagaatc
     4681 tgatatcatc attgctatca ataaagaccc agatgcacct atctttgatg tagctgatta
     4741 cggtattgtt ggcgatgcat taaagattgt tcctaagtta acagaggcaa tcaaagctca
     4801 ggttaaataa tttcaaatca tatcagactc attagattat gtgagttact gattgagaat
     4861 tgaaacttag attttttgtg gaagtctagt atatgcattc tcagatgttt tgtgtattga
     4921 cgattcatta ttaaaagaag catataggag atttgtgctg aactctataa aatgtattta
     4981 tgcagggaat ctttttgaag attccctgtt aaagtgagat agtaggacta cagtttataa
     5041 ctgtggtcct ttttactttc attcagttgg catagcccgc tacgccgtct tcattcagga
     5101 aaaattcccc acaaatcatt cctacaatct gcacgcccca atttgcggta tattttgcct
     5161 tcattcagtt gacgtagccc gctacgccgc cctcattcag gtaaaatctt ccacaaattg
     5221 taacgcacat cttgcagaaa gcatttttca aacacgctct agtaaaatac gtcattttta
     5281 ttttatatat aataaaaagt aaacataata aagaagtact tatcacaaaa taaacataat
     5341 ttgtcaaaaa tagtggaaat taattccaaa tatgttataa tactcttgca gcagttaacc
     5401 gagatatgag aggaggcatt tatggcacaa attattgctt caacaaaaga aatatctaat
     5461 aagagagagt cactgatagt attgagtaat tccttaaaga ataagatttc gcttttagaa
     5521 actttgggga acagtcttaa ttctatgtgg gaaggcgctg caaaagagaa gtatgtaaag
     5581 caacttaaga cagacatttc aaagatgcgg aacttactta agacaatttt ggaatttata
     5641 ttgatactag agaagattat tgcaatctat aataaagcgg agaagaagaa tgaggcgaca
     5701 gcggtaagct aggaggggga tttatggcag atttaattaa tgtaactcca gagaagttaa
     5761 aggcgacagc aagttctttc caacaggcag gaaaggacgt taagaaaact acttctgata
     5821 tgcttcagtt agtgagggga attagtagtt ccatctggag tggagaggcg agtagtatat
     5881 atcttggtaa gtttaatgga ttggatgccg atatcgccaa gatgtgcaag atgatagaag
     5941 aagaatcaca gcatttgaca acaattgcac aggaatacca gttagcagaa gaacagaata
     6001 aacaggttgc ggcaacatta aagaataatg taattgctta gattgtatag acagatgaat
     6061 agattatgct gtcagttatg attttttgtc acgacaaaag agaaggagat ttgattggaa
     6121 agatatgtaa tcagtgtgta gcgcttatag ataaagagtt tttacgtaat tttatcataa
     6181 gcgatgaaga atatcatcag gtgaatatag agggaataca gccgccagat ttacttgtag
     6241 tagaaatcac aggtatagag gatttatgca gagcgaaacg aataaggggg attttcccaa
     6301 gaggacgatt gctagttgta agtactaatc agatttcagc agagtactat ttaattccgg
     6361 aagtttcacc ggatatgctt ttactgaaac catatgtata tgcgaaagct tgtaagatta
     6421 tacaccgaag tcttacatgg tgttgtaagg ataagtgtag aaagaaaaag caagaagata
     6481 tattaaagat tcggacagga ggagagattt attattttca ttatgaagag attcagtatt
     6541 tagaagcaag agataagaag attatcttgc atgtaaataa gtatgagatt tctttttata
     6601 gttccttgca aaagttggag aagagcctgc cagattattt tattcgttgc catcgtagtt
     6661 atattgtgaa ttttatgttt attcaaaaag cagatttgat aaatggtgaa ttttatttga
     6721 ataaaaagac agttattcca atttctcaga aatataaggc caaattagca aaaatgttgt
     6781 aaaaatataa ggattcaagg ttcgatttag gttgaccgag ttatacaacg gtggtagaat
     6841 atactcatga tattttttta acaagagcag aagttgttag gaggagaagc atgagtttca
     6901 ttaaagaata tgcacagaaa cttgttacag cagaagaagc ggttaaggta gtaaaatctc
     6961 atgattgggt agattatggt tggacaaccg gtactccagt tgcattggat gcagcattag
     7021 cagccagagc agatgaatta gaagatgtta agattcgtgg tggtatctta ttaagagaac
     7081 cagagatttt caaggtaaat aatgtagcag atcattttac atggaattcc tggcatatgg
     7141 gtggtttgga gagaaaggca atcagtaaag gatttgcata ctattctcca ttaaaatatt
     7201 cagaacttcc acgttattac agagagaata tcaagcattt gaatgttgcg atgttccagg
     7261 ttgctccaat ggataaacat ggattcttta actttggacc aaatgcatcc catatgatgg
     7321 cagtttgtga agctgcagat gtaattatcg tagaggttaa tgagaatatg cctcgctgtc
     7381 tgggtggatt tgaagaaggc attcatgttt ctcgcgtaga ttacatcgta gaaggcgaga
     7441 atccagctat tggtgagtta ggagctggcg caccaccaac agaagtagac aaagccgtag
     7501 cacagcttat tgtagaagag attccagatg gagcatgttt acagcttggt atcggtggaa
     7561 tgcctaatac agtaggttcc atgattgctg aatctgattt aaaggactta ggtgtacata
     7621 cagagatgta cgttgatgcg tttgttgaca ttgcaaaggc aggaaagatt acaggcttaa
     7681 agaagaatat cgacagagga cgtcaggtat atgcattcgg tgcaggtact aagaagatgt
     7741 atgattatct ggatgataac ccagaatgta tgagtgcacc agttgattat acgaatagcg
     7801 ctaagacaat agcacagatt gataacttta tttctatcaa taatgcagtt gatattgact
     7861 tatatggtca ggttaatgca gagagtgcag gtataaaaca gattagtggt gcaggtggac
     7921 agcttgattt cgttcagggt gcatacttat ctaagggtgg taagagtttt atctgttgtt
     7981 cttctacatt tacatccaga gatggtgtaa agcatacaag aatcagacct actttagcag
     8041 aaggctctac agtaacagat actcgtccta atacacatta tgtggtaaca gaatttggta
     8101 aggtatgcct taaaggtatg tctacatggg aaagagcaga agcattaatt aatattgctc
     8161 atccagattt cagagatgaa ttaattaaag aagcagaaaa gatgcatatt tggagaagaa
     8221 gtaacaaata ataatcacag ctttgaataa gatatcatat gtcgggaaat tagctaaaaa
     8281 gtaaaaattt aaggcaagat atcaagaaac ctctcacaca aaagataaac aaactgcaag
     8341 tttgagatga ttttgtgtgg gaggtttttt aatttaataa atatttacag ctagaatgtt
     8401 tttcaaacac gttctagaat attcacaagt aaataatatt aaaaacagta gtgtaataat
     8461 tgtggaagta tcaatgtaat atttatttag aatctaatat gtttataaag tttattctga
     8521 atgtaatatt actttaaaac aagattatca atatttctta tgataatcgt tgatttacca
     8581 gttacatctg tttgaacttc aaagttagcc agtttgttat aagtttccat tggaatagat
     8641 atttcgattc cgctatcagt taccatgacc tgcttttcta atttctttac agtactttca
     8701 ttggtgacag taaagttatc atattgtaag tcgtactgtt ccattttttc atcaaattct
     8761 gatttttttt ctggactttt tccgaaaagt ttattaccta tttcttctat atcgaaagat
     8821 ttgttatcaa cgtattcttt ttgaagagca ctttttgtat ccatctttgt ttttaaatcg
     8881 gcaccatcgt atttattaga aatattatta ataacacgag taagaatatt taacttcttt
     8941 tttggaggaa tactggtacg gcagacaaga aagttttccg ataaataata agctttctca
     9001 ccatttatct catacttttt ttccaaaagc tttatgtgat aattggataa attaataact
     9061 acggcctcag gtattcttga agttgcagaa ggaagcagag aatgtgtttt gatgatgtct
     9121 gtattaataa caggattatc aggagtctcg gtgacttcat gcgtatagct ttccttgtaa
     9181 ttcattttta aaagggcaag atagataatt ccttctgcct gaaaggttac gaataataaa
     9241 tcggcagcgg gtatatctaa tccctctccc atggcaatat agagtttatt tgcaatggcc
     9301 tgactggttt caatgaaaga agtttcatct gattcatccc atgtttctaa gatggaatag
     9361 attggagaat attctgggtc aaattcacag tttttggtat catcgctgga aacaatttta
     9421 taaatatggt ttcgaataaa atcatgtaaa tctggccctg gatctaagag agtattagaa
     9481 agaatacatt ctccgcgatt ggtgtctaaa atatgcaaaa tagcttttct tataacaata
     9541 tcatcttttg ctatcatgag gcagctcctt tattttttat ttgattaaat agtataccac
     9601 tttaggagta aagaagctat gagattttta atttttatat acggaaaaag caggatgaaa
     9661 cgcacacagc ttgtcagcgg taagagagca gagtgtcata tattattacc taaagatgat
     9721 ttctctttgg aaaggacagt atttttacag tttaaaaata tatctggaga atggtttatc
     9781 aaggaaacag actgttgtca tttgaaaaca gaagaatttt ttcagatggg aaaacggaaa
     9841 agtgatgaag gaatatttta caagttgtca atagggagaa agaatgaact atcggtaggt
     9901 gggaaggatc tttatataca gcttatacga tataggaatg actggagcat atataagaaa
     9961 tataaactta gagattgtcg gataataaaa gagaaaaata tattcataat gatggagaaa
    10021 gccattaata gaaaaaatag tatgggtatt tcatatgagt atggcaaatg gttcatagag
    10081 aaatgtggga atatagaaat atatattaat gaaattttgt tagagaaaaa gcagcaatta
    10141 gagtttggtg atgttatatg tattggaact atatatttgt tattttttga gaactatata
    10201 gcagtagaag ctggtgagag aaatatagta tcagattatt tggaagaagt aatattagaa
    10261 aatgagataa agggacaaga ggatgttagg aagaaggaaa aaagagagat aacttttcac
    10321 agggcaccga gagtaatgga agaattaaaa aaagtatcat taaaagttga tgcaccgccc
    10381 caagtggatg tacaggagaa aaaatctata tttatggata taggtactat catgaatctg
    10441 atgtttccaa tgttaggaat gaacttattt ttaatttatg gaatgaaatc agagcagaat
    10501 caggcaggaa tatatgtata ttctggactg tttatggcag tgatgtcagc ggtatgttct
    10561 attttatggc ttatgatttc gagaaagtat gaaaaaagag aacagcagaa gaaagttaat
    10621 aaagagcgac tggcttatag gagatatttg aataaaaaaa gtgaatatat caaagtgcag
    10681 tatgaacggg tatataaggt tttacaaagt agatatttac gggcagatac ttatttagat
    10741 agcccattat tagatatgta tttatggaat cgaaatctat atcataaaga ttttttaatg
    10801 tacagaattg gtataggtga cgttgagttt cctatgaaaa tagaatttcc tgaggaagtg
    10861 tttggcgatg aggaaaatat tctatggcgg gaagcaaaaa agataaagga acattatgag
    10921 attctacatc agattcctgt gttactcgac atgggaaggt atagtcagat tggaatcata
    10981 acaaaagata cgatagcagg aatggaactt gtaagaagta ttattttaca gattgcgttg
    11041 tgtaattgtt atacggaagt aaagatagga tgtatttata acaaaaataa ggttattcaa
    11101 tcgcagcaat gggatttttg caggtggctt ccgcatatat gggatgccaa tagacaaaag
    11161 cgatttattg cagggaatga ggtagaagcg aggcggttat tctatgattt gttgcagatt
    11221 tttaaagaaa gagaagaggt atccatatcc gataagtcag aaaaaatttt gccacattat
    11281 attttatttg ttgcagaaga acaatttttg gaaggagaaa tgttttctaa atatatttta
    11341 gatagaggaa aagaatatgg attgacagtt gtatggctgg actcgatgag aaaaaaattg
    11401 ccgaatacat gtaaaatggt attggaaata aatgggggat ttactgggcg gtatgagata
    11461 gaaaggcaca gtcagaagaa agagaaaata aattttgatt atacggaaaa aaatattgcg
    11521 gagaaattaa taaggagtat ttcaggaata aaagtgatgg aaattgaaga aaaggctggt
    11581 ataccagaag ttgttgattt tttaggaatg tatgatgtgc acacgataga agaattacat
    11641 ataaaacagc gatgggaaaa gaatagaatt tttgaaagtg caaaggtttt aataggtaaa
    11701 aaagcgggag atgaaccttt ttatttagat atacatgagc gatatcatgg accgcatggt
    11761 ttattggctg gaacgacagg ttcagggaaa agtgaagtac ttcagacatt tattttatcc
    11821 atggcagtga attttagtcc ggaagcggtg tgctttttgt taattgatta taaaggagag
    11881 gggatgtcag cgctattttc tgaattacca catatttcag gaaaaatatc gaatttatca
    11941 gatgggcagg catatagagc aatggtatca ataaaaagtg aaaataaacg aaggcaaaga
    12001 atatttaaag aatgtaaggt aaataacatt aatgattata caaggttgtt taattcggga
    12061 agtgtaaacg aaccaattcc tcatttactg attattattg atgagtttgc cgaattaaaa
    12121 aaggcggagc cggaatttat gcaggaatta attagtgttg ctcaagtagg gaggagctta
    12181 ggtgttcatt tgctgctggc aactcaaaaa ccaggaggtg ttgttgacga taagatatgg
    12241 agtaattcaa gattccgaat ttgtcttaaa gtgcaggaaa gggaagatag catggatatg
    12301 cttcataaca tggatgcctg ccagattaca caaacaggaa gaggatactt gcaggtaggg
    12361 aataatgaag tatatgagtt gttccaagca ggctgg
//
