LOCUS       c00105_gnlPro..        10061 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KIIOHMHI_105.
ACCESSION   c00105_gnlPro..
VERSION     c00105_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:17:34
            Original ID  :: gnl|Prokka|KIIOHMHI_105
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10061
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10061
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3821:9429]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3822..9429
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10061
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10061
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             297..1481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.8; E-value: 1.2e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg105_1"
                     /sec_met_domain="MFS_1 (E-value: 1.7e-25, bitscore: 78.8,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGNPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(1748..2713)
                     /locus_tag="ctg105_2"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHASDYNAQTGVTVLYFPLGAKVGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDARTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(2838..3473)
                     /locus_tag="ctg105_3"
                     /transl_table=11
                     /translation="MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWLTGLIFAALYKSPAKKFSYYIASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(3822..4181)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_4"
                     /sec_met_domain="ALS_ss_C (E-value: 8.8e-23, bitscore:
                     69.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFARMKEILYIK
                     VFNCSREDKAELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVV
                     RGGSVRIESISMMER"
     CDS             complement(4383..5096)
                     /locus_tag="ctg105_5"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAMKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPRLKVFLQTR"
     CDS             5859..7115
                     /locus_tag="ctg105_6"
                     /transl_table=11
                     /translation="VKSMERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPVRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERRRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             complement(7184..7693)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_7"
                     /sec_met_domain="ALS_ss_C (E-value: 3.9e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKCYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(7711..9429)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-49, bitscore:
                     157.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIQEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             complement(9939..10061)
                     /locus_tag="ctg105_9"
                     /transl_table=11
                     /translation="ISTDKVQSQTLNTGGTAENIFALGKQAQGVFYYIYSNPLK"
ORIGIN
        1 atgtgtatgg tgtcagaaat ggtatggtgc acatcttttt ttgcgggaaa tatttggaat
       61 cggatggggg tattactttt tggattttat agaattgtta tagggaaaaa gtcaaaataa
      121 tataaaaatt tatgggattt tcaaaagata atgaaagaaa aaggagagaa tctgtgatac
      181 actgtcatta ttgacggata gaaatctatt agaactgtgg agatatagaa gtttggtgga
      241 tcaatgtctg aatgatgtca gcttaataaa tttcagattg gaggatataa catcggatga
      301 aaacaaatta caacagaaca gtgcaggcct gttttatcgg atatgtagtg caggccattg
      361 tgaacaattt cgttcctctg ctgtttctga catttcaggg cagttacggg atttcgctgc
      421 agaagatcac acttctggtt acttttaatt tcgggatcca gttgctggta gatctggcat
      481 cgattggatt tgtggacaga ataggttatc gtgcatctat gatcctggca catgcaatgg
      541 cggctgcagg tctgattttg ctcacagtat tgccggagtg cctgggaaat ccgtttgtgg
      601 gacttctcat tgcagttatg atctatgcca ttggaggcgg attgctggag gtgctggtaa
      661 gtcctgtggt ggaagcctgc cctacagata ataaggaaaa agcaatgagt ctccttcatt
      721 ccttttactg ttggggacat gtgggagtgg tacttctttc tacattattc tttcgtattt
      781 tcgggattgc aaactggaaa tatatggcgc tggtgtgggc attgattccc attgcaaatg
      841 gaatcttttt taccagagtt cccattgctc cactgctgga tgagggtgaa aaggggctga
      901 ctatgggaga gctttttaag aaaaaaatct tctgggttct gatgttaatg atgctctgtg
      961 caggagccag tgagcaggcg gtaagccagt gggcttctac tctggctgag aaaagctttg
     1021 gaatcaataa aactatcgga gatctggcag gtcccatggc gtttgcaatt cttatgggaa
     1081 gttcaagggc attttatgga aaatttggag ataaaatcaa tctggaacgc tttatgcaat
     1141 acagtgcagt tctgtgcatg gtttcctatc tgatgatcgc atttatcccg gtacctgcgt
     1201 tgggaatcct tggatgtgcg gtttgcggtc tgtctgtagg tattatgtgg ccgggaacct
     1261 tcagcatggc ggctgcctca gtaaagcgtg gcggaacagc cctgtttgcc ctccttgccc
     1321 ttgctggaga tgtgggatgc tcatccggac caacctatgt ggggatgatt tcaggagcac
     1381 tgaatgataa tctgaaactt ggaatctttg cggcactgat tttccctgtg ttgatgataa
     1441 tggggattaa gatgattgga agtctgcaaa aatatgattg agatatatta aaaagtatgg
     1501 aacgattaat ttttcatatt gatgtaaaca gcgcatttct ttcctgggag tcagccagaa
     1561 gggtaagcca ggggctgccg gatctcaggg agattccctc ctgtgtggga ggagatccaa
     1621 agaaacggac agcaaatgta cagctctggc ttggagaaaa accagagcac agatgaaaaa
     1681 tgaagacaga caggaagaat aaaagcgcag ggatgatact ttttctctgc gcttttatag
     1741 cggactgtta tacatatttc agaaattctt catcctggat ccgggaagta tggatggcat
     1801 tttggatagc ctgagccatg acttctgcgg cgagagttcc tgccatattg atatctacag
     1861 aaacatcgcc aatgctggca gcatagatgg aatcgccgtc agccatagtt gctacaggat
     1921 tgatgcatct ggcataggca cagcgggtca tagaggcaat tttattcagt tcagcctttg
     1981 aaaatgcccc attggtgatc acagccccga tggtggtatt gccggtaaac tggtcatgag
     2041 gtgtcataaa gcggtataat tcgtggacac tatccagaaa cccgcttctg tcaggcgttt
     2101 tcagccctgc gattttctga ccattttgtg gactaaagat atctcccagt gcattgacaa
     2161 cgacaattgc ggccatctgg aaatttccca ctgatacagc ggcaatacca agacctgact
     2221 tcatggattg tttcataccg taaagttttc ccacagttgc accggtacct gcgccgatat
     2281 tcccggttct ggcatctgtt ccggcaaatg cctgacggca ggcttcctcg cccatttttg
     2341 cagttggacg tattttagga tctccgtaag agaggtcata gatacaggac tggcatacaa
     2401 ggggaaccag tgctgcaccg gtgttataac cgatattttg tgattccaga tagttcatca
     2461 caccgtcagc agcagccagt ccataggcag aacctccgga caagacaatg gcgttgatag
     2521 gattgtcggc agtaacagga gaggtgagag gagtttccct ggaagcagga ccgccaccgc
     2581 tgatatcaca gccaaccttt gcacccagtg ggaagtaaag aacggttacc ccggtctggg
     2641 cattataatc ggaagcatga ccgatacgta aatttgaaag ctctgtaata gaaatctctt
     2701 ttaataatga cataaaaatc tcctttgtat taaccgaatc aggtaggatt cctgctttaa
     2761 atgtgccgga tagaaaaatc ctgactacag tgacaatgta gtcaggattg tttggtaaac
     2821 ggctgttctt ttaaagatta tgcacgtttc agtgccacag aaagtgcctt ggaaacgatg
     2881 cttcccacta caaagcagaa gcccgcttcg atcagtccct gaacgcccac aaaagcagca
     2941 acgaagacaa caggattgct tactccaaga ctggaaacaa taccctgaat gtaatctgtg
     3001 ttgtagaaga agagacataa aaagcccatg aagaagaaag tattcagtaa cgggcatgcc
     3061 agtgaagcaa tgtaatagga aaatttcttc gccggtgatt tatataatgc tgcgaaaata
     3121 agtcctgtaa gccatccttc cagcacacgt gccacgatac atacaataaa agtaccaaat
     3181 ggattgatgt tgaaaagtgc agcagcgaaa gctgaacttc ctgtgacagc catatagaag
     3241 ctggttgcac cgaaagcaag tccgcataca gcaccacctt tcggtccgag gatgatagct
     3301 cctacagcta ccgggatggt gagaagagtg atggataagc cgggagtacg aagatagccc
     3361 agcggggtaa aggacatgag cagaataatg gcgatcatca tagccagctc taccatgtaa
     3421 agagtgctgc ttctttttgc ggcagctgtt gtagtggttg ttgttgtatt catatgaatt
     3481 ctccttttgg tctgataaaa cggcgcaatg cgtcccctgc ttttcagaca gtttagagta
     3541 tggggatcag gcgttatgaa aaatatgcat cagaacaaaa gaaaaatttc cggtgtgtag
     3601 acgccttaca ggtcgcctca cgaatttaac cagactgtga agtggatgac tttatccacc
     3661 agactgtcag atgtggaaaa cagatgcatt ttctttcgaa taacgctccc gtaaaccata
     3721 acacatttga ttaaaaactg caatatttta tagtatgttt gaaaataaat acaggatata
     3781 gaggtgtttc tatatcctgt aaaaaatatt gattatgaga tttagcgttc catcatgctg
     3841 atggattcaa ttcttacgct tccaccacgt accacttcaa ttctgtggaa ttcttccttg
     3901 atcagtttga caactgcatc attcttggtg gctgtctgga caaattccag aagcaggctg
     3961 tctttgccgt agtcaatgac ttttgccttg aaggtttctg caatctgaaa cagttctgct
     4021 ttatcttccc tggagcagtt gaaaaccttg atgtagagaa tttctttcat tctggcaaat
     4081 acatctgtga agtcgattac cttgataacc tcgatcatgc ggtttaactg ttttttgatc
     4141 tgttcaaagg tttcatcatc gctgactgtt gcgatagtca ttcgggatac tgtaggatcc
     4201 tcggtggttc ctacagtaag actgatctat cacgagatat gtaaatggtt aagtgagttt
     4261 tgttaattaa aatatactaa aatattgtct tttttgacaa gaaattatag aaaataaaca
     4321 aaataacaca atgcaaaaaa caatgcataa aataaaagaa tgtccctttg aggaacattc
     4381 ttttaacgtg tctgaaggaa aacttttaat ctgggaagct ggttgttaag gataagagtt
     4441 tccggaaaca tgagctggtg aacgaattct tcggcatagg tgaaatctcc aacatgttct
     4501 tttccgtggc tgtcgctgga caaaataaca ggaagctgat atttctgaca gagatacagg
     4561 attctggcgg cattggctct tgtgtctccc cgatatcctc cgggtgcgag ggaagcttcg
     4621 tttatttcaa aaataacatt ttcccgtaaa gctgctcttg ccagcgtttc ataatctaca
     4681 gggaaatgtg tatcgtcgca atggccgagt atttttacag caggatgttt cattgcattg
     4741 atgtaagctt ctgtattctg agatacagag cctgaacggt agttctgccg atgcatactg
     4801 atgatagcgt aatccaggtt gttcagcagt tcatctgaca gatctgtatg tcctgcactg
     4861 tccaggatgt ttagttcaac tccgtaaaga atatctatgc cgaatctttt tctgggataa
     4921 aaaggaaggc ttctgaaata agaagaagtt ccggaagcca gagttcccgg gccgtggtca
     4981 gaaatcccaa ggagtttcag tccttttttg ctggctgctt ttgccatgtc agagatggta
     5041 caggtggttc cgtgaccgct ggcgatagaa tgtgtgtgga tgtcagaaag atacattgtt
     5101 tgtctccttt ccagagcggt ttctatatat gataagagcc ttacggaaga tgcaaagctg
     5161 ctgtttgatg gtacattcgt tatattcaag tatgacagat gaggatttaa atgtcaatga
     5221 ggaaacaaaa taaaaacaac tgaaatacaa caaaaatcaa ataaaaagca acacaaataa
     5281 acggctgata catgttaaat tatgttgact tcgggaaaat gagaaggtat aatggaacta
     5341 tatgaaaaca agggggctta ttgctgatca atgacagcga tagcactgtt tgcttatgtg
     5401 tagacagtta cttcatgaga aaggagtaac atggaaaaat ttcaaacatc agacattccc
     5461 ggaattctct tatgaatggc tggaggctga actggatact ggtatgattc cacaaatatg
     5521 gacagcgaag aaattgctcc taacctttat gactaatcga taagtatata tcgagaggaa
     5581 atgaatcctc agaattaagt aaaaaaagtt accgggaaca atgtgaccgg cagcgaaata
     5641 cagacgccgc actgccgtat ggcaagtgcg gcgttgttgt tcaaaactct gatagcagag
     5701 tgaaatcaaa caaatataaa tacagtaaca gctcagacaa gatgatgcaa ataaagacac
     5761 ttttttggac aaacgaggtt cttaccttgg agagcagatc agggtaaaat gaaatcatca
     5821 gatatgaaga gcgcaattca tatattggag gaagaacagt gaaaagtatg gaacgattaa
     5881 tttttcatat tgatgtcaac agtgcatttc tttcctggga atcagccaga agggtgagcc
     5941 aggggctgcc ggatctcaga gaaattcctt cttgtgtagg aggagatcca aagaaacgga
     6001 caggtatcgt ggttgccaaa tctatccctg caaaaaaata cgggatccag accggcgagc
     6061 cagtagccat ggctcttcgg aaatgtccca atctggtgat cgttcccagt gattttgaat
     6121 tatacgataa atgttcccgg gcatttaaag caatctgtgc ttcttttgca cctgtgatgg
     6181 aatctttttc cattgatgag gtatttctgg atatgacagg tacttctctg atttatcctg
     6241 accctgtagc tgctgctcat gagctgaaag acaagattca cagagagctg ggatttacag
     6301 taaatgtggg aatttctact aataagcttt tggcaaagat ggcatcagat ttccagaagc
     6361 cggacagagt acacactctg ttcccggatg aaattccgga gaaaatgtgg cctcttcctg
     6421 tccgtaacct attgtttctg ggaaaagctt ccgagcagaa gcttctgaat cagggaatcc
     6481 gtaccatcgg tgatctggca agagaaagag catccaatgt gcagtactgg cttggggaaa
     6541 aaacgggaca tcagctatgg caatatgcca gaggtattga tgattcccct gtaaaagcag
     6601 tgcctgatga ggcaaaaggt ttcagcgtgg aaactacttt taacgatgat attacttcca
     6661 tagagcaggt gtttcccata cttttggagc agtgtgatgt tctggcaacc agaatgcgca
     6721 gaaaagataa gaaatgcaac tgtatttctg tgactttccg tactttggat ttcagaaacc
     6781 gttcacacca gacaaagctg gaaaatgcta cagatcttac agatgaaatt tatataaatg
     6841 ctacaagact ttttaaagaa ttctggaaag gacagccgct acgtctgatt ggtgtggcgc
     6901 tgacaggcct tacagacggc acttatgaac agatgtctct gtttgaagat acagaaaata
     6961 aagaacgccg cagaaagctg gatgcagcta tggatgagat ccggatgaaa tttggaaatg
     7021 ataagatcac ccgtgccagt attatgaaca gcaatgcacg gattgggcga aaagcgaaag
     7081 cacagatgaa aaacgaaaag acagaagaac cgtaagtaaa gggaggactg agcattaaga
     7141 ataatgcgac aatcctccct ttataaaaat ttcagaaaaa gttttatcgt tccatcatac
     7201 tgatagattc gattcctaca cttcctccac gtaccacttc aattctgtga aattcttcct
     7261 tgatcagttt cactactgcg tcattcttgg ttgctgtctg gacaaattcc aggagcaggc
     7321 tgtctttgcc atagtcaatg acctttgcct tgaaggtttc ggcaatctga aacagttcaa
     7381 ccttatcttc tttggaacag ttaaaaacct taatatacag aatctctttc atgcggacaa
     7441 atacgtctgt gaaatcaata accttaataa cctcgatcat acggttcaac tgttttttga
     7501 tctgctcaaa agtttcatca tcactgacag ttgcaattgt cattcgggat actgtagggt
     7561 cttctgttgt tcctactgta agactgtcca ggttataaca ttttccggaa aaaagaccgg
     7621 aaattttgga cagaacaccc acctggttct caacatagag agaaatccat ctttttttca
     7681 ttcctttatc cataataatt ttcctcctga tcaacagtcc ataatcatat cttccagagt
     7741 tccgcctggt ttgatcatag gataaaccat ttcctcaggg tcaatgatga attcaattac
     7801 tgtaggtgcc tttgtgttct tttttgcttc ctcgaaggct gctgcaattt cctctttctt
     7861 tgtgacacgg attccttttg ccctgtagct ctctgcaagt ttgatgaaat ccggcgtgta
     7921 ctgtggatat tccatgccct ctgtgcggcg ggaaagtgct ccggcgcgca ggttggtcat
     7981 ggcgtagcgt ttgccgtaga aaagcttctg ccactggcgt accattccaa ggtattcatt
     8041 gttaaagatg cacaggataa caggaagttc ttccagaact gcagttgcaa gctcctgaat
     8101 gttcatctgc acaccgccgt caccggagat aacgatgaca ggtctgtcgg gatttccgat
     8161 tttggctccg atgccgcctg gaagaccata gcccattgtt cccagaccac cggacatgat
     8221 catctgtttg ccctctgtga tttccgcata ctgggagaca agcatctgat gctgtcctac
     8281 atctgttacg ataatactgt tctcaaactg ttcgttgatc tctttcagga tatccatcgg
     8341 acttaaaaga tcatttggac gcattttaag cggatgctct tctttccagt ttttgatcag
     8401 gttaagccac ttgtccgttg aacattcctg gacgtattcg ttcattttgg tgatagcctc
     8461 ttttgcatca gcaacaatgg ggatatccac ctgaatgttt cgggaaatgg atgctgtatc
     8521 aatatcaatg tggataatct gggcatgtgg tgcaaattca tgaagttttc cggtgattct
     8581 gtcattgaat ctggttccga tggagaacag cacatcgcag ttgctgactg ccatatttgc
     8641 tgcataggca ccatgcatgc caaggtttcc gatatagagc ggatggtctg tggggataga
     8701 gccttttccc attacggttg tgacaaccgg tacttttgtc ttttccacta cttcccggaa
     8761 aatttcatgg gcgcgggaga ttactacacc gccgcctgcc aggaataagg gacgttttgc
     8821 tttatttaaa agtttgatgg cacgtttgag ctggccgatg tggacatctg tgttgggctt
     8881 gtatccgcgg atgtttacat ttttaggata ttcagcgctg ccgagttctg ccattacgtc
     8941 ctttggaagg tcgataagga caggtcccgg acggccggtg cgggcaatgt agaaggcttc
     9001 ttggatgata cgtcccaggt cttcacgtct gcggacagta acgccgtatt tggtgatgct
     9061 tctggtgatt cctacgatgt ctacttcctg aaatgcatcg ttgccgatga ggtggcgggc
     9121 tacctggcca gtgaagcata caagaggtac gctgtcatag ttggcggttg caagtcctgt
     9181 tacaaggttg gttgctccgg gaccgctggt taccagacat acgccgactt tgccggtggt
     9241 tctggcgtag gcgtcggctt cgtggacaag ggcctgttcg tgacggggga ggatgatttt
     9301 gacatcgtcc tgtttgtaga gttcatcact gatgtcgatg gtacaggctc cggggtagcc
     9361 gaagaggtat tctacgcctt cttcttttaa ggcttttact aagagtttgt tgccggatat
     9421 ttgtttcata tttgggtaaa cctcctttgt gtatgtgtat aggacgctcg gaaatttatt
     9481 tgttttcggg tgcggtttcg gggtctagga actctaagtg tctgaaaatc tgctaaaacc
     9541 gttcagaaaa atctcaaact cgccgcggat gcggctcaga cagtgagatt tttctgaaca
     9601 acgcagattt ccaggcacta agagttacta cgactcctgc aaatgcaccc gaaaacaaat
     9661 aaatttccga gctgtgtatt ggcgaataca gggtggggca gaatggcgct gcgctgattc
     9721 tgccgagtgt ggggcggcgg gtttgatgtg acagatgtaa atgatgttag ggtcaaaagg
     9781 tattttgacc ctgatatcta tagcaatcct cgtaaataat gcatttaaga cagttcagca
     9841 gagtgcgaaa gacaaggaag atatctgcag gcgtgctgac gcacggcaaa gatatctgac
     9901 gcaggatttc acactctgat gggctggatt aagatgcatt attttagagg attgctataa
     9961 atatagtaaa aaacgccctg ggcttgtttg cccagggcga aaatgttttc cgcggtacca
    10021 cctgtattca gagtctggct ctgcactttg tcagtactga t
//
