LOCUS       c00033_gnlPro..        14543 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBHCLEGA_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:58:31
            Original ID  :: gnl|Prokka|LBHCLEGA_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14543
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14543
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[259:4543](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(260..4543)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14543
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14543
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(260..4543)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_1"
                     /sec_met_domain="HGD-D (E-value: 2.7e-60, bitscore: 195.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4e-38, bitscore:
                     121.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAILDQEDHLLFSDYERHFANIQETL
                     SSLLQKAYDALGDFAVAPMITGSGGLTLAKHLGVPFVQEVIAVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDATGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKAAFIRTLNLDDEHAITPENSHLFAAIGSALNYKPGETTTLVSLRDRLSDGIKM
                     EFEVARMDPLFASQKEYDAFRARHDGHNVRSADLSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLATAIRSIKEIYTLLPPKAKIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHFYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNYSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASQLGKNIVVQGGTFYNDAVLRSFEKIAGVECVRPDIAGIMGAFGAAL
                     IARERHEAGYQTSMLSIEQINALTFDTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGLGKEKNKDNIPNLYEYKNKRLFDYTPLSAEEAARGTVGIPRVLNMYENYPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCIPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVDEITSGQVKFLNPFMSFASEETLSSQLIKTFG
                     QSEFGIPESEIRDAVAEGWKELAVCRMEMQKKGEEVLQYLKETGRRGIVLAGRPYHVDP
                     EINHGIPELITSYGIAVLTEDSISHLQPVERPLIVMDQWMYHSRLYAAANYVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLISAIRVRE
                     KKQTKRTIVPANYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFQTAGYNLVVPDVDS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMAAVMSGGYDMSRTAVLISQTGGGCRASNYIGF
                     IRRALEKAGYPDVPVISINLSGLEKNPGFKLTLPLIQHGLYALEFGDIFMRCVYATRPY
                     EAVAGSTDELHEKWKKEVIAFITQKKMLSHGKFKKMCREIIRDFDNLPRKDIKKPRVGV
                     VGEILVKFHPAANNHLVELLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGMSQKSKKI
                     GRLGINFFEWLRSAARDEFTKSRHFTAPAHIDDLARYARDIVSEGNQTGEGWFLTGEML
                     ELIHTGTPNIVCTQPFACLPNHVVGKGVIKELRHRYPGSNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQNAPEQKDQAAG"
     CDS             4733..5662
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="LTKISPTDILNNVMSFLERSGTEYMNWLNKLERKFGNWAIPNLIV
                     WLIGAYTIGFVLYRVNPSIIGLLMLSPYHILHGQIWRLITWVFMPTDTNLVYLLIMALF
                     YYQLGTTLERTWGTFRFNVYIFGGMLFTVIGAFLLYGIMYLLNGGVTTEMLLIGTSFST
                     SYINMSIFLAFACMYPDMQVLLMFIIPIKMKWMAAVYGVLIALSFFETGWAGRMAIFMS
                     LLNFIIFFFSTRNLKRYTPHEVHRRQKFKADMRRPQGYAGGAKHKCAVCGRTELDDPTL
                     EFRFCSKCEGNYEYCQDHLFTHQHIRLS"
     CDS             complement(5758..6858)
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MAGSTLGTLFKITTWGESHGKGVGVVIDGCPAGLSLCEADIQKFL
                     DRRKPGQSRYATPRKEDDAVEILSGVFEGKTTGTPISLVVFNRNQQSKDYSEIASYYRP
                     GHADYTFDQKYGFRDYRGGGRSSGRETIGRVAAGAVAVKILNELGITFMTYTKSIGPIA
                     VSSGRFDFSEVTKNPLYMPDAEAAENAENYLDACMTELNSSGGIVECIIKGMPAGIGDP
                     VFEKLNANLAKAVMSIGAVKGFEIGDGFDVAKATGKNNNDAFVLGEDGRIAKATNHAGG
                     ILGGMSDGSDIILRAAIKPTPSIAATQRTVNQSGEEISVNIKGRHDPIIVPRAVVVVES
                     MAAITIVDSLFSNMSARMDALKDFYS"
     CDS             6983..8308
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MIEKYLVKKITEPVDWKVTVPGSKSMTNRALLMAVLSAGTVRVEG
                     VLFSDDSRHFLACLVALGFTVEIEEEKKCVTVTGCGGRIPRGEAVIDVGSAGTAARFLA
                     AMLGFSDGCYEIRCSAQMKRRPMAELFDLLSGAGAKITFLEEEGHLPVRITGCRYARAD
                     KTAGETPRELSLDITKSTQFLSALLLIAPMVPEGMKIHITSEKTDGSYIRITRRMMQEF
                     GVSVAFDGRDYEVPCRSSYRKETYMVEPDMSAACYFYAAAAVTGGRTLVRHVHMDNTQG
                     DLRFLEVLEHMGCTADDTPEGILVTGPADGALRGITVNMNDFSDQALTLAAIAPFADAP
                     VRIEGIGHIRGQECDRIHAIQTNLTALGIRCEEEETAATIYPGSPHGGSVETYDDHRVA
                     MAFSLVGLRTDGIVIENPACCRKTFENYFTVLSELTGKTVES"
     CDS             8413..9564
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MYELLKQEGRAKRGVFHTVHGDIQTPVFMNVGTVAAIKGAVSTED
                     LEQIKCQVELSNTYHLHVRTGDKLIKEVGGLHKFMSWNRPILTDSGGFQVFSLAGLRKI
                     KEEGVYFHSHIDGAKIFMGPEESMQIQSNLGSTIAMAFDECPPALAERKYVEDSVARTT
                     RWLERCKNEMQRLNGLEDTVNRHQMLFGINQGAIYTDIRIDHAKRISELDLDGYAVGGL
                     AVGETHEEMYHVLDETVPYLPVNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRH
                     GHVYTNQGKINLFNQKYEKDMRPIEEGCGCPTCRRYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNTMMEEIRDALDAGNFASYKEEKLYGMEQINREKEMAK"
     CDS             9663..9980
                     /locus_tag="ctg33_6"
                     /transl_table=11
                     /translation="MFSILATESASSAGWISMVVWLVILFAFMYFFMVRPQKKEQQKKN
                     SMLAELAVGDTVLTTSGFYGTVIDITDDTVIVEFGSNKNCRIPMQKAAISAVEKPEDVT
                     E"
     CDS             10069..12564
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MKSKKNTFVSRAAVGCVTTAIFLLLCIIKGIYPFGIATLDTVDFQ
                     SQWIPAYYHVWDVLHGDGSAFFDWRVGGGNNFAGVSAQFSLFSPFNLFFLFVKRSWIEK
                     SMIVFLLIKLLAMGYGMRWFLKEQILKEERYGIYILAGSVGYAVNGYTLLYYGMGWLDV
                     AAILPLLCYFFCRMAEREGDWRLGKNTLGYIVCLTLVFLINIPQAYMMCFFLIVFAGGY
                     FFLKRQDQPLKKNGILKFGLTSLLSLGIAAVIFLPAARAMLGSYRLSGEEYRGISGYFL
                     LLRQDGMDAVWKWVILGSVAVPLLFFVISGRRKREHIWQWYLVAAMVLPVFFEAVNLIW
                     HRGTYVCFPMRYGYMLVFAVICMAAARVPDFVGDSRVRRNILYAFLGIWCVQMVALGIS
                     LIQPETHTDETDFVGDATEIGQPLAGKTDVFHKAKLADGAIDNNYPLIAESTSYSNYLH
                     LMTSEQIRMNTLLGYSQVWTRLSDTGGTLASDIMLGYRYYVASKAGSWGKDTAADSLWP
                     LAETEKFTLWENAPVGDRAFFITKADYEAYVVTEAYTENVFENQNRLSELLFHTVPIDW
                     KKETYLDDQTGAELSYRFYADGKQILYLYGKDLQQAEITVNGERLYVPDYNDLYNESYP
                     ATGNQGILSLGCFSDEDITVEIRQSVGDSGAERAVFFGFLDPQELLEAVDAAGRAVTYE
                     LARDSCKLTVESAGAEYLMLPVNADSGWHCTVNGEERAISRLAGNLMLVPLDEGTNEIT
                     LCYVPRGMKKGAAVTGMALMLLAGWGVLSRLLRRKSVLDKIYAGLGCAAADIFAVVYAG
                     FLLVVYVIPVVYTIYLRWI"
     CDS             12574..14058
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MEKLQARKKVYLWLLILLSLCALIPLAVLSKYNHQSGDDYGYAYR
                     TFQIWRETHSFWNVIKEAFATSAEFYQKWQGLYASAVLLALEPGIFGDKYYALTGILLL
                     AIIVGANCAGTVYIFHRKCGCPRLEGFAAGCVMSFLMIEWMPSALQGLYWYNGAMNYVF
                     FHAVLLLLLCVLLSLAGEHPRRKAGRTVLAVLLAVLLAGGNHVTAFMGILLIVGFGIFA
                     AVKKRRQNLICCVITLAAMVAGFLFNVTSPGTRIRQSYFSDRPGVAGTIVTAVKTGIAC
                     INSWMGLAVIVTAVLLLPVLLPLVKKIRGQYGFSFRYPLLVFVLSVAWLCAMFCPPIYA
                     MGTPGDVRLTNVVYFSFVWLFVLNEAYLCGWAVTRLEASGAAALSGAAGEFPGSFLITA
                     AVLAVGMIIGCGENMTAWQAYLLIRSGEAQEYSAEADERYAVLCDSAGEDVVLKAYTAK
                     PWMLFLDDITEEKSDWRNEYMRVYFGLNSVVLEQTE"
ORIGIN
        1 agaggtgcca ataagggaca cacacaaaag tcctaaaatt gtctgctggc ttgcggacac
       61 agtccgtgga gtgttccaaa cttggaaaga cacggatcat cacggatgcc agctgcggca
      121 tggttagaaa taccggattt tgcggtcaga atttgccgcc gcatgtttat ctggaacttt
      181 taagtatctg tttcccataa tattatttat cacttgaagg ggctgcacat ttgatgcgta
      241 gcccctttct ctgtatctgt caccctgcag cctgatcctt ctgctccggt gcgttctgct
      301 ttgccagatt tttgttcgcg gtggagagca tcagcttgat acggttgagc tggtttacct
      361 cgctggcacc cggatcgtaa tcgatggcca cgatattgga acccggatag cggtgacgca
      421 gttccttgat gacacccttg ccgaccacat ggttcggcag gcaggcgaac ggctgcgtgc
      481 agacgatgtt cggtgttccg gtgtggatca gctctaacat ctcaccggtt aagaaccagc
      541 cctcgccggt ctggttgccc tcggatacaa tgtctcttgc atatctggca agatcatcga
      601 tgtgcgcagg tgcagtaaag tgcctgctct ttgtgaattc atctcttgca gcgctgcgca
      661 gccactcaaa gaaattgatg cccagacggc cgatcttctt ggacttctgg ctcatgccga
      721 gattgtctgc tttaaagccc gtattgtaga agcagtagag caggaaatcg gtcagatccg
      781 gtacaacggc ctctgcaccc tcggattcga gaagctccac cagatgattg ttggcagccg
      841 gatggaactt gacaagaatc tcgccgacaa cgccgacgcg cggtttcttg atgtctttgc
      901 gaggaaggtt gtcaaaatcg cggatgatct cgcggcacat tttcttgaac ttgccgtggg
      961 agagcatctt tttctgggtg ataaaggcga taacctcttt tttccatttc tcgtgcaact
     1021 cgtccgttga tccggcaacc gcctcgtaag ggcgcgttgc gtagacgcag cgcatgaaga
     1081 tatcgccaaa ctccagcgcg tagagtccgt gctggatcag tggcagtgtc agcttaaagc
     1141 ccgggttctt ctccagaccg ctcagattga tcgagatgac cggaacgtcc ggatagccgg
     1201 ctttttccag tgcacgccgg atgaagccga tgtaattgct ggcgcggcag ccgccgccgg
     1261 tctgggagat taagaccgcg gtgcgcgaca tatcataacc gccggacatc acggccgcca
     1321 tcagctggcc aaccacgatc agggacgggt agcaggcgtc attgttgacg tactttaagc
     1381 cgacatccac gcaggtgcgg ctgtccacat ccggaacaac aaggttgtac ccggccgtct
     1441 ggaacgccgg ctccaacagc tcaaaatgga tcggtgacat ctgtgggcag aggatggtgt
     1501 aattcttgcg catttcctcc gtgaagacga cgcggttgta attcgccgga acgatggtgc
     1561 gcttcgtctg cttcttctca cggacacgga tcgccgagat cagggaacgg atacggatac
     1621 gcgccgcacc gaggttgttg acctcatcga tctttaagca ggtgtagatc ttgccggact
     1681 ttgtcagaat atcattgaca gcgtctgtcg tgacggcatc cagaccacag ccgaaggaat
     1741 tcagctggat gaggtcgaga tcgtctcttg tcttgacata gttcgccgct gcgtacagtc
     1801 tggagtgata catccactga tccatgacga tgagcgggcg ctccaccggc tgtaagtggg
     1861 agatggaatc ctccgtgagc acggcgatgc cgtaggaggt aatcagctcc ggaataccgt
     1921 ggttgatctc agggtctaca tggtacggac gacctgcgag gacgataccg cgtcttccgg
     1981 tctcctttaa atactgtaag acttcctcgc cttttttctg catctccatc cggcagacgg
     2041 caagctcctt ccagccttcg gcaaccgcgt cgcggatctc ggattccgga atcccgaact
     2101 ccgactgacc aaaggtctta atcagctggg aggaaagcgt ctcctcgctg gcgaaagaca
     2161 taaacggatt taagaacttc acctgaccgg aagtgatctc gtccacgtta tttttgatat
     2221 tttccgcgta ggaggtaacg atcggacagt tgtagtgatt gttggaatcc gggaattcgt
     2281 tgcgctcata aggaatacac gggtagaaaa taaaatcgac gttctggtgg atcagccatg
     2341 tcacatgacc gtgtgccagc tttgccgggt agcactcgga ctcgctcggg atggaatcaa
     2401 ttccaagctc gtagatcttg cgcgtcgact gcggggagag taccacggaa aaaccgagct
     2461 tcttaaagaa agttgcccag aacgggtagt tctcgtacat atttaaaacg cgcggaatac
     2521 cgactgtgcc gcgtgctgct tcctcggcgg aaagcggggt gtagtcaaac aggcgcttgt
     2581 tcttgtattc gtagaggttt ggaatgttgt ctttattttt ctccttgccg aggccgcgct
     2641 cacagcggtt gccggtgata tactggcggt tgccggaaaa gcggttgatt gtgaggagac
     2701 agtggttggt acatccctga catcttgcca actttgtgtc gaaggtcagc gcattgatct
     2761 gctcgatgga aagcatggag gtctggtagc ctgcttcgtg acgctctctg gcgatcagtg
     2821 cggcaccgaa agcacccatg atgccggcaa tatccggacg gacacattcg acgccagcga
     2881 ttttctcaaa actgcgcagt acggcatcgt tgtaaaacgt accgccctgt acgacgatat
     2941 ttttcccgag ctggcttgca tcggaaagct tgattacctt aaataaagca ttcttgatga
     3001 cagagtacgc aagccccgca gaaatatctg caacggatgc gccctctttc tgcgcctgct
     3061 ttaccttgga attcataaat acggtgcagc gggttccaag atcgatcgga tttttggcaa
     3121 aaagagcctc ctttgcaaaa tcctgtacag agtagttgag ggattttgca aacgtctcga
     3181 tgaaagaacc gcagccggag gaacaagcct cattgagctg tacggaatcc accgtctgat
     3241 tcttgatctt gatacatttc atatcctgac cgccgatgtc taagatacag tcgacttccg
     3301 ggtcgaagaa cgcggccgca tagaaatgag ccaccgtctc aacctcgccg tcatcgagca
     3361 tcaaagcggc ttttaacagc gcttcgccgt atccggtgga gcaggagtgg acgatctttg
     3421 ccttcggtgg aaggagcgta tagatctcct tgatggaacg gattgccgtt gcaagtggac
     3481 ttccgttgtt gttgctgtag aaagaataca aaagggaacc gtcctcgccg actaaggcaa
     3541 tcttggtcgt ggtggaacct gcatcgatgc ccagatagca gttgccctca taagtggaga
     3601 gatctgcgga cctgacattg tgtccgtcgt ggcgcgcacg gaaagcgtcg tactctttct
     3661 ggctggcaaa cagaggatcc atacgggcaa cctcaaattc catcttgatg ccgtctgaga
     3721 gccggtcgcg gagagagacg agcgtggtcg tctcacccgg cttgtaattt aaagcggaac
     3781 cgatcgcagc aaacagatgg gaattctccg gtgtgatggc gtgttcgtcg tccagattca
     3841 aggtgcggat aaaagcagcc ttgagctcgg aaaggaagtg aagcggacct ccgagaaagg
     3901 caacatgacc gcggatcggc ttaccgcagg caagaccgct gatcgtctga ttgaccactg
     3961 cctggaaaat ggaggcggac agatcttccc tggtagcccc ctcgttgatt aacggctgga
     4021 tatcggtctt ggcaaagaca ccgcaacgcg cagcgatcgg gtagatggcc ttgtaattct
     4081 tggcgtattc attcagacct gtcgcatccg tctggatgag ggatgccatc tggtcgataa
     4141 aagaaccggt accgccggca cagatgccgt tcatacgctg ctcgacattg ccgccctcaa
     4201 aatagatgat cttggcatcc tcaccaccga gctcgatggc aacatcggtc tgcggtgcat
     4261 aatgctgcag ggcagtggac acggcgatca cttcctggac aaacggaaca ccgagatgct
     4321 tggcgagtgt cagaccgccg gaaccggtaa tcatcggtgc aacagcaaag tcgccgagtg
     4381 catcgtaagc tttctggaga agggaggata aggtctcctg gatattggca aaatggcgct
     4441 cataatcaga gaagagcaga tgatcctcct ggtctaaaat tgcgaccttg acggttgtgg
     4501 aaccgatgtc gattcccaat ttatgaagtg tattgttttc cataattccc tccatggctg
     4561 tttctcgtaa agtaaatact ttagcagagt aaaatatgta aaagatttct tcttattata
     4621 aatagtgcca atctggcgat aaacactcta cattatacga caggatatgt caaaagacaa
     4681 tgtgcatttt gccggaaaag tataaacttt ttgtaaagaa gaatccctct gattgacaaa
     4741 gatttccccg accgatatac tgaacaacgt aatgtcattt ttggaaaggt cagggacaga
     4801 gtatatgaac tggttaaata aattagaacg taaattcggc aactgggcga ttcccaatct
     4861 gatcgtgtgg ctgatcggag cttacacgat cggatttgtg ctctaccggg tgaacccgtc
     4921 gatcatagga cttttgatgt tgagcccgta tcacatcctg cacgggcaga tctggcgcct
     4981 gattacctgg gtgtttatgc ccacagatac gaatctggtg tatcttttga tcatggcgct
     5041 tttctattat cagcttggaa cgacgctgga gcgcacctgg ggaaccttcc gttttaacgt
     5101 ctatattttc ggtggtatgc tgtttaccgt catcggagca tttctgctgt acggtatcat
     5161 gtacctttta aacggcggcg tgacgacgga gatgcttctc atcggaacga gcttcagcac
     5221 aagctacatc aacatgtcca tcttccttgc gtttgcatgt atgtatccgg atatgcaggt
     5281 ccttctgatg ttcattatcc caattaagat gaagtggatg gcggctgtgt acggcgttct
     5341 gattgcctta agcttctttg agaccggatg ggcgggaaga atggcgattt ttatgtcgct
     5401 cctcaacttt atcattttct tcttctccac cagaaacctc aagcgctata cgccgcacga
     5461 ggtgcacaga cggcagaagt tcaaggcgga tatgcgcaga ccacagggat atgcgggcgg
     5521 cgcgaagcac aagtgtgctg tctgcggcag gacggaactc gacgatccga cgctggaatt
     5581 ccgtttctgc tccaagtgcg agggcaatta cgaatactgt caggatcatc tgttcacaca
     5641 tcagcatatt cgcttgagtt agaaagtatg aaaaagaaaa aggtgatact tcgattgcgc
     5701 cagccggcgt agaagaagta tcaccttttt tgttctgttc cctgtagacg gagtctatta
     5761 ggaataaaaa tcttttaacg catccatccg tgcgctcata ttggaaaaga gtgagtcgac
     5821 gatcgtgatg gctgccatgg attccaccac gacaacggcg cgcggaacga tgatcggatc
     5881 gtggcgtccc ttgatgttga ccgagatctc ctccccggac tgattgacag tgcgctgtgt
     5941 ggcggcgatg gaaggggtcg gcttgatggc agcccgaagg atgatgtcgc ttccgtcgct
     6001 catgccgcct aagataccgc cggcatggtt ggttgctttg gcaatcctgc cgtcctcacc
     6061 gaggacaaag gcatcgttgt tgttcttgcc ggtcgctttt gctacgtcaa atccgtcccc
     6121 gatctcaaaa cctttgacgg caccgatgga catgaccgcc ttggcaaggt tcgcattaag
     6181 cttctcaaag accggatctc cgataccggc aggcattcct tttatgatac actccacgat
     6241 gccgccggag gaatttaact ccgtcatgca ggcatccaga taattttcag cgttctcggc
     6301 tgcttcggcg tccggcatat agagcggatt ctttgtgacc tcggaaaaat caaagcgccc
     6361 ggaagatacg gcgatcgggc cgatggactt tgtgtaggtc ataaaggtaa tgccgagctc
     6421 gtttagaatc ttgacggcga cggcgccggc ggcgacacgc ccgatggttt cccgcccgga
     6481 ggagcgcccg cccccgcggt agtcgcggaa gccgtatttc tggtcgaacg tgtaatcggc
     6541 gtgaccggga cggtaatagg aggcaatctc gctgtagtct ttggactgct ggttgcggtt
     6601 gaagacgaca agcgagatcg gggtgccggt cgtctttcct tcaaacacgc cagagagaat
     6661 ctctacggcg tcgtcctctt tgcgcggcgt tgcatatctg gactgaccgg gcttgcgccg
     6721 gtcgagaaac ttctggatat ccgcctcaca gagagaaagt cccgccggac agccgtcgat
     6781 gacgacgccg acgccctttc cgtgagattc cccccaggtt gtgattttaa aaagagttcc
     6841 caaagtagac cctgccatgt gattccctcc tgcttacata atgatctttc tcgattataa
     6901 aagatttgac tttgcgccgc aacagaaata tgttatgatt tgacggagca gaagtaccag
     6961 caggcgagga gaagaatatt tcatgataga gaaatacctt gtgaaaaaga taacagagcc
     7021 ggtggactgg aaggtaaccg tgccgggatc gaagagcatg acgaaccgcg cgcttcttat
     7081 ggcagtgctg tccgcaggga cggtgcgcgt ggaaggagtc ctgttttccg atgattccag
     7141 acactttctg gcgtgtcttg tggcgctcgg ctttacagtg gagatagagg aagaaaaaaa
     7201 gtgcgtgacc gtgacgggct gcggcggcag gattccccgc ggggaggcgg taatcgacgt
     7261 cggaagcgcc gggacagcgg cgcgttttct tgcggcgatg ctcggatttt cggacgggtg
     7321 ctatgagatc cgctgctcag cgcagatgaa gcggcggccg atggcggagc tgttcgatct
     7381 gctttccggt gcgggagcga agattacatt cctcgaggag gaagggcatc ttccggtgcg
     7441 catcacagga tgcagatacg cccgggcgga taagacggca ggggagacgc cgcgggagct
     7501 ctctcttgac attacgaaga gcacacagtt tttaagcgcg ctgctgttga ttgcgccgat
     7561 ggttccggaa gggatgaaga tccacatcac cagtgagaag acggacggct catacatccg
     7621 catcacgcgg aggatgatgc aggaattcgg cgtgagtgtc gcttttgacg gaagagacta
     7681 cgaggtgccg tgcagaagtt cctaccggaa agagacttat atggtggaac cggatatgtc
     7741 ggctgcctgc tatttttatg cggctgcggc tgtgaccggc ggacggacgc ttgtgcggca
     7801 tgtgcatatg gacaacacac agggagatct gcgtttcctg gaagtgttgg agcacatggg
     7861 atgtaccgcg gacgatacgc cggagggcat cctggtaacg ggaccggcgg acggtgcgct
     7921 acggggcatc acagtcaata tgaacgattt ttccgatcag gcgctgaccc tggcggcgat
     7981 cgcgccgttt gccgacgcgc cggtgcgcat agagggaatc ggacatatcc gtgggcagga
     8041 atgcgaccgg attcacgcga tacagacgaa cctgacagcg cttggcatcc ggtgtgagga
     8101 ggaagagacg gctgccacga tctatcccgg cagcccccac ggcggaagcg tggagacata
     8161 cgacgatcac cgcgtggcga tggcattttc cctggtcgga cttagaaccg acgggattgt
     8221 cattgagaac ccggcgtgct gccgcaagac gtttgaaaat tattttaccg tgttaagcga
     8281 actgactggg aaaacggtgg aaagctgaca agatgccgga ctgcacaagg ctggtggaag
     8341 tgaaagcgga aaaagcgcag aaccagagaa aataaagaag aactacaggc aataaaagga
     8401 gacgaaaaac agatgtatga attattaaag caggaaggac gcgcgaagag aggcgttttc
     8461 catacggtgc acggagatat ccagacgccg gtatttatga atgtgggtac ggtggctgcc
     8521 atcaagggag ctgtctccac ggaagattta gagcagatca agtgtcaggt ggagctgtca
     8581 aacacctacc atctgcatgt gcgcaccgga gacaagctga tcaaggaagt gggaggactg
     8641 cacaagttta tgtcatggaa tcgtccgatt cttacggatt ccggcggatt tcaggtgttc
     8701 tccctggctg ggctccgcaa gatcaaggag gagggcgtct atttccactc gcatattgac
     8761 ggggcaaaga ttttcatggg accggaggag agcatgcaga tccagtccaa tctcggctcc
     8821 acgatcgcca tggcgttcga tgaatgtccg ccggcgcttg ccgagcggaa atatgtggag
     8881 gattccgtgg cacggacgac gcgctggctg gagcgctgca agaacgagat gcagcgcctc
     8941 aacggtctgg aggataccgt gaaccgtcac cagatgctgt tcggcatcaa ccagggagcc
     9001 atctacacgg acatccggat cgaccatgca aagcggattt ccgagctgga tctggacggc
     9061 tatgcggtcg gcggacttgc ggtcggcgag acacatgagg agatgtacca tgtgctggat
     9121 gagaccgtgc cttatcttcc ggtgaacaag ccgacctatc tcatgggagt cggaacgccg
     9181 gccaatattc tggagggagt ggagcgcggc attgacttct ttgactgtgt ctacccgtcc
     9241 cgcaacggcc gccacggtca tgtatacacg aatcagggca agatcaacct gttcaaccag
     9301 aagtacgaga aagatatgcg cccgatcgag gagggctgcg ggtgcccgac ctgccgccgc
     9361 tacagcagag cctatatccg ccatctgctc aaggcaaaag agatgcttgg catgcgctta
     9421 tgcgttctgc acaacctgta cttctacaac acgatgatgg aagagatccg ggatgcgctg
     9481 gatgccggaa attttgcctc ctacaaggaa gaaaagttat acggcatgga acagatcaac
     9541 cgggaaaagg aaatggcaaa gtaaaaggga aaaggcttgc caaacggcga ggttttgtgt
     9601 acaatatttt ctaatggggt cagacgactt cggacaagtt tatgatttta ggaggatatc
     9661 agatgttttc aatcttagca acagagagcg cgtcatccgc aggctggatc agcatggtgg
     9721 tatggctggt tattttattt gcatttatgt atttcttcat ggtgcgtccg cagaagaaag
     9781 agcagcagaa gaagaactcc atgcttgcag agctggcagt tggagatacg gtcttaacga
     9841 caagcggttt ttacggaacc gtgatcgaca tcacagacga tacggtgatc gtggagttcg
     9901 gaagcaacaa gaactgccgc atcccgatgc agaaggcggc catctccgca gttgagaagc
     9961 cggaagatgt aactgaataa gaagattttt aagagggata gtatataaaa tgtattatcc
    10021 cttttctttt tgagagagta tttcggagag cgaggagaga ttgtccggat gaaaagtaaa
    10081 aaaaatacgt ttgtttcacg tgccgccgtc ggctgcgtga caactgccat ttttctgctg
    10141 ttgtgcatca taaagggcat ctatccgttt ggaattgcca cgcttgacac tgtggatttt
    10201 cagtcccagt ggattccggc atattaccat gtatgggatg tgctgcacgg agacggcagc
    10261 gccttttttg actggagagt cggcggcggg aataattttg cgggagtgag cgcgcagttt
    10321 tctctgttca gcccgtttaa cctgttcttc ctctttgtga aaagaagctg gattgaaaaa
    10381 tccatgatcg tgtttctttt aatcaagctg cttgccatgg gctatggcat gcgctggttt
    10441 ttaaaagagc agatccttaa ggaagagcgt tacggaatct acattctggc gggaagcgtg
    10501 gggtatgccg taaacggcta tacgcttttg tactatggca tgggctggct ggatgtggca
    10561 gcgatcctgc cgctattgtg ttatttcttc tgcaggatgg cggagcggga aggggactgg
    10621 cgtctcggga aaaatacgct cggctatatc gtctgcctga cgctggtatt cctcatcaat
    10681 attccgcagg cgtacatgat gtgttttttc ctgatcgtgt ttgcgggggg atattttttc
    10741 ctgaaacgac aggaccagcc gctaaaaaag aacggcattt taaaattcgg gctgacttct
    10801 ttactgtcgc ttggaattgc ggcggtaata tttctgccgg cagcgagggc aatgcttggt
    10861 tcctaccggc tgtcgggcga ggagtaccgg ggaatctccg gctattttct gctgcttcgg
    10921 caggacggaa tggacgcggt gtggaaatgg gtgattcttg gcagcgtggc ggttccgctg
    10981 ctgttcttcg tcatttctgg cagacggaag cgggagcaca tctggcagtg gtatctggtg
    11041 gcggcgatgg tgctgccggt tttcttcgag gcggtcaatc tcatctggca ccgcgggacg
    11101 tatgtgtgct tcccgatgcg atatggttat atgctggtgt ttgccgtgat ttgtatggca
    11161 gcggcgcgcg tgccggattt tgtgggagat agccgcgtgc ggcggaacat tttatatgcg
    11221 ttcctgggaa tctggtgcgt gcagatggtg gcgcttggca tttctttgat acagccggaa
    11281 acgcacacgg acgagacgga ttttgttggg gatgccacgg aaatcggtca gccgcttgcg
    11341 ggaaaaaccg atgttttcca caaggcaaag ctggcggacg gagcgattga caacaactat
    11401 ccgctgatcg cagagagcac ctcctactcc aattatctgc atctgatgac gtcggagcag
    11461 atcaggatga acacactgct cgggtattct caggtgtgga ccagattaag tgacacgggc
    11521 ggaacgctcg cgtccgacat catgctgggg taccgttatt atgtggcgtc taaggcggga
    11581 tcgtggggaa aagacacggc ggcggattcc ctttggccgc ttgctgagac cgaaaagttt
    11641 acgctgtggg aaaatgcgcc cgtcggggac agggcatttt ttatcacaaa agcggactat
    11701 gaagcgtatg tagtcacgga agcgtacacg gaaaatgtgt ttgagaacca gaaccggctg
    11761 tcggagctgc tttttcacac agttcccatt gactggaaaa aagagaccta tctggatgat
    11821 cagaccggag cggaattatc gtaccggttt tacgcggatg gaaagcagat cttatatctc
    11881 tatggaaagg atctgcagca ggcagaaatt acggtaaacg gggagaggct ctacgtcccg
    11941 gattacaatg atctgtacaa tgagagctac ccggcaactg gcaatcaggg aatcctctcc
    12001 ctcgggtgtt tttcggacga agacatcacg gtggaaatcc gtcagtctgt tggggacagc
    12061 ggcgcagaga gagcggtgtt cttcggattc ctcgatccgc aggaactgtt ggaggcggtg
    12121 gatgcagcgg gaagggcggt tacatatgaa ctggctcggg attcctgtaa gcttactgtg
    12181 gaatcggcgg gagcggagta tctgatgctt ccggtcaatg cggatagcgg atggcattgt
    12241 acggtaaacg gagaggagcg ggccataagc cggctcgcgg gcaatctgat gctcgtgccg
    12301 cttgacgagg gtacgaatga gattacgctt tgttatgtgc cgcggggaat gaaaaagggc
    12361 gcggcggtga cgggcatggc actgatgctt ctggctggct ggggcgtttt atcacgtctg
    12421 cttcggagaa aaagtgtcct ggataaaatc tacgccggac ttggctgtgc cgccgcagat
    12481 atttttgcgg tggtctatgc cggatttctg ctggtcgtct atgtgattcc ggtggtgtat
    12541 acgatatatt taagatggat ctgaggtaac agaatggaaa aattacaagc gagaaaaaaa
    12601 gtatatttgt ggctgctgat tttattgagc ctttgcgcgc tgatcccgtt agccgtactc
    12661 tcgaagtaca atcatcagtc gggggatgac tatggttatg cctaccgcac cttccagatc
    12721 tggcgggaga cacattcttt ctggaatgtg ataaaagaag cgtttgccac atcagcggag
    12781 ttctatcaga agtggcaggg gctttatgca tcggcggttc tgctggcgct ggaaccggga
    12841 attttcggcg acaaatatta cgcgctgacc ggaatcttgc tgctcgcaat tattgtgggg
    12901 gcaaactgcg cgggtacggt ttatatcttt caccgcaaat gcggctgccc gagactggag
    12961 ggatttgctg ccggctgtgt catgtcgttt cttatgatcg aatggatgcc ctccgccctg
    13021 cagggattgt actggtataa cggcgcgatg aattatgtat tcttccatgc ggtgctatta
    13081 ttgttgttgt gtgtgctgct cagccttgcc ggggagcacc cgcggagaaa agcaggcagg
    13141 acggtgcttg cggtgctgct tgcggtgctg cttgccggcg ggaatcacgt gaccgcattt
    13201 atggggatac tgctgattgt cggatttgga atatttgctg cggtaaaaaa gcggcggcag
    13261 aacctgatct gctgcgtcat aacgcttgcg gctatggtgg cgggattcct ttttaatgtg
    13321 acgtcgccgg gcaccagaat ccggcagtcg tatttttccg acagacccgg tgtggcggga
    13381 acgattgtta ccgcggtaaa aaccggaatt gcatgcatca acagctggat gggacttgca
    13441 gtcattgtca cggcggtcct gctgcttccg gtgcttcttc ccctggtaaa gaagatacgc
    13501 ggacagtatg gattttcgtt ccgctatccg ctgcttgtct ttgtgttgtc ggtcgcctgg
    13561 ctgtgcgcaa tgttctgccc gcccatctac gcgatgggaa cgccggggga cgtccggctg
    13621 acaaacgtgg tatatttttc cttcgtttgg ctgtttgtgt taaatgaagc ctatctgtgc
    13681 ggatgggcgg tcacaagact ggaggcgtcc ggggcggcag cactgtccgg ggctgcagga
    13741 gaatttccgg gcagtttttt gatcacggct gctgtccttg cggtgggaat gataatcgga
    13801 tgcggggaaa atatgaccgc atggcaggca tacctgctga tccgcagcgg cgaggcacag
    13861 gaatattcgg cggaggctga tgagcgctac gccgttttgt gtgattctgc gggggaagac
    13921 gtggtgttaa aggcgtatac cgcaaagccg tggatgcttt tcctcgacga tattacagag
    13981 gagaaaagcg actggagaaa tgaatatatg cgcgtctatt ttggactgaa cagcgttgtg
    14041 ttagagcaga cggaatgaga cggcagaagg gagcagcgga cacaaaaggc aggctgctcc
    14101 tttttcataa gacccggtta tagggagtat gaaaaagaaa aatggattca gaggttgcat
    14161 tgtttcccga gatacattat tatagaattt atatatactg tctgttagta atgtactaaa
    14221 gtcaatacaa gacggattcc tgcatggcag gaagaaaaga gggattagag agatggaata
    14281 taaggtaggc gtgatttccg gcgacgggat cggaccggag atcgtaacag aggcaaagaa
    14341 agttctggat cagattggaa agacctacgg acatgtgttc cgctatgaag agattctgat
    14401 gggaggctgc tccattgacg cgacgggtga gccgctcacg gatgcggcga tcgcttccgc
    14461 gaaggcttcc gatgcggtgc tgatgggttc gatcggcggc aacacatcga cttcgccgtg
    14521 gtatcagctg ccgccggaga aga
//
