LOCUS       c00079_gnlPro..        13273 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBHCLEGA_79.
ACCESSION   c00079_gnlPro..
VERSION     c00079_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:58:31
            Original ID  :: gnl|Prokka|LBHCLEGA_79
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13273
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13273
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1613:6844]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1614..6844
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13273
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13273
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             220..1428
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_1"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.4e-50, bitscore:
                     161.7, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRRFLSLLLSMSLLIFSPVRVRAQDVPAESELYAKSAVLMDADS
                     GRILYEKNGHEAMANASTTKILTCIVALENCDPASVVTVSKNAASQPKVHLGMHEGQQF
                     YLRDLLYGLMLESYNDCAVAIAEFAVGDVQGFAALMNAKAEELGCEDSYFITPNGLDAK
                     DDAGFHHTTAADLAKIMKYCIKESLKSDEFLEITRTAQYSFSDTEGKCTYQCTNHNAFL
                     QMMEGALSGKTGFTGTAGYCYVGALQREDKTLIVALLACGWPNNKTYKWSDTRKLMNYG
                     LEQFKKIDLLQIEPDEAELAPIEVRDGQGGQIGETVYLKPVVRNYAGEESILAPLSSEV
                     TLKYEIADQLYAPVKSGEYIGKIRYMLGEETLAERCVVAGETIGKIDYPWCLGQVLRLL
                     WIE"
     CDS             1614..3050
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_2"
                     /sec_met_domain="CT_Vparvula (E-value: 4.2e-125, bitscore:
                     407.9, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSSNDSLAMQRITRLVDENSFIEIGSLVTARSTDFNLAATDTPS
                     DGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAVYDMAMKMGAPVIGFIDCAG
                     VRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGNCGGGLAVVPALSDFAFIEESKGK
                     MFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDEILADIRELVGMLPLNNEGD
                     VYTDECADDLNRACESMDAMKGDPRYLLSEISDSHTFFETKAGYARDMVTGFIKLNGMT
                     VGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFCDAFEIPVLTLTNVKGYKAC
                     KCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVAMNSKSIGADFVYAWPDAKV
                     GMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAARRGYVDLIVDPADTRKYLVD
                     AFELLYTKCAYTPDKKHGTK"
     CDS             3037..3789
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-25, bitscore:
                     80.0, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDASADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKVAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             3831..4196
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.1e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGTGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             4212..5360
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_5"
                     /sec_met_domain="OAD_beta (E-value: 2.9e-157, bitscore:
                     512.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPIAFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             5426..6844
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_6"
                     /sec_met_domain="HMGL-like (E-value: 1e-45, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.3e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             complement(6908..7390)
                     /locus_tag="ctg79_7"
                     /transl_table=11
                     /translation="MRDITPATNFIHTLMQSPPDASAWIAGGNNFPSISGLARFYATKY
                     EGTLVEVEVFGLPNVATPGSSNFYGMHIHENGVCVSPFTSAGAHYSRTPAEHPNHSGDM
                     PPLLGNQGYAWMAFYDKRFTIPEIIGKSLIIHRMPDNFTTQPAGDSGERIACGVIK"
     CDS             7552..8484
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_8"
                     /sec_met_domain="SIS (E-value: 1.5e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             8477..9706
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.4; E-value:
                     2.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_9"
                     /sec_met_domain="HI0933_like (E-value: 5.2e-137, bitscore:
                     446.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEEQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             9725..10387
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_10"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.5e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             10393..11244
                     /locus_tag="ctg79_11"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDTVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQTLGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVEIIKEKGYDIIVLNTICNATEERQTEARVIAEQVDAMIVIGGRNS
                     SNTQKLFEICKNECKNTYYIQTVKDLDLAEVRSVDNVGITAGASTPNNIIEEVQKNVRN
                     EL"
     CDS             11225..12343
                     /locus_tag="ctg79_12"
                     /transl_table=11
                     /translation="MSEMSFEQMLEESFKTIRNGEVVEGTVIDVKPDEIVLNIGYKADG
                     IITRNEYTNEANVDLTTLVSVGDTMEAKVLKVNDGEGQVLLTYKRLAAEKGSKRLEEAF
                     ENKEVLTAKVAQVLDGGLCVNVDETRVFIPASLVSDTYEKDLSKYKDQEIEFVISEFNP
                     KRRRIIGDRKQLLVAKKLEQQKELFARIKIGDVLEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVESPKKVFKVGDQVRVFIKDINENKIALSMKFPAENPWNGAAEKFAIGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISKEHVEKPSDVLKVGQEIEAKIVDFNEEEKK
                     ISLSMKALLAPEEDADADVADVDIDAVAKEEE"
     CDS             12450..13271
                     /locus_tag="ctg79_13"
                     /transl_table=11
                     /translation="MLETDNYEKFKKDILALAKIDLNSYKEKQMRRRINTLITKNHIAT
                     YDEYVALIKKDKEKFEQFINFLTINVSEFYRNPDQWKILENEVFPKLIQKFGKNLKIWS
                     AACSTGDEPYSLVMALSRHLPLANIKVIATDIDKQVIDTARMGLYNEKSIASVPDDLKK
                     KYFTKVGNSYQISDEIKKRVEFKEHDLLKDPYPGGCNLIVCRNVVIYFTEEAKDEIYAK
                     FYKALATGGVLFIGSTEQIMNYREIGFERDKSFFFEKTVYYAVGFSLCILIP"
ORIGIN
        1 aagatgcaaa catccggctg gttagaaatg ccacattttt tgaaccgaat ttccatccgc
       61 attttcatct gaaatcccac ggtgtagtct acttataata ttacttatca aagcaaagca
      121 cgatatgctt attgcggcag ttcctttttg cgtgccgttt ctgttctgca aaaaatgagg
      181 gatgcatata catcagtgaa gtcattttgg gagaatggca tgtatcgacg ctttctttct
      241 ctattgttaa gtatgagctt acttattttt tcgcctgtgc gtgtccgggc gcaggatgtg
      301 ccggcagagt cggaactgta cgcaaaatct gccgttttga tggatgcgga ttccggaaga
      361 attctctatg agaaaaacgg gcatgaagcg atggcgaatg cgagcacgac aaagatttta
      421 acctgtatcg tggcactgga aaactgtgat ccggcgagcg tggttacggt gtcaaaaaat
      481 gcggcgtcac agccgaaggt acatctgggg atgcacgagg gacaacagtt ttatctgagg
      541 gatcttttat atggcctgat gctggaatcc tacaatgact gtgcggtggc catcgcggaa
      601 tttgcggtgg gggatgtgca gggatttgcc gcgctgatga atgcgaaggc agaggaactc
      661 ggctgtgagg acagctactt tattacaccg aacggactgg atgcgaagga tgatgccggg
      721 tttcatcaca cgacggcggc agaccttgct aagattatga aatattgtat taaggaatcg
      781 ttaaaaagcg acgaatttct cgagattaca cggacggcgc agtattcttt ttctgataca
      841 gaggggaaat gcacgtacca gtgcacgaac cacaatgcat ttttgcagat gatggaaggg
      901 gcgctttccg gaaaaacggg atttaccgga accgccggat actgctatgt cggagcgctg
      961 cagcgggagg acaaaacgct gatcgtggcg ctgctcgcct gtggatggcc gaacaacaag
     1021 acctataagt ggtccgacac cagaaaactc atgaattacg ggttggagca gttcaaaaag
     1081 atcgacctgt tgcagattga gccggacgaa gcggagcttg cgcccataga ggtgcgggac
     1141 ggacagggcg gacaaatcgg cgaaacggtg tatttaaaac cggttgtcag gaactatgca
     1201 ggggaggaga gtatcctggc gccgctaagc agtgaggtta cgcttaagta tgagattgca
     1261 gaccagctgt atgcaccggt gaagagcggc gagtacatcg ggaagattcg ttatatgctg
     1321 ggggaggaga cgctcgcgga gcgatgtgtg gtagccgggg agacaatcgg aaagatcgat
     1381 tatccgtggt gtctggggca ggtgcttcgg cttctctgga tcgaataaaa aacacaaaca
     1441 aaaagcgtca aaaaattaac aatttacttg aaatattgca gaaaagcaat tataatttaa
     1501 catagcgtaa tttgttgaat ttttatacaa agacgcatgg atttacatca ttcactatga
     1561 agccgcatcc caaatggatg tggacaacaa tttatagatg gagggcaaaa agaatgaata
     1621 gtagcaatga tagcctggct atgcagcgca tcaccaggtt agtcgacgag aacagtttca
     1681 ttgagatcgg ttctctcgta accgcaagaa gcacagattt taatcttgca gcaacggata
     1741 ctccttccga cggagtcatc acaggacacg gcctgattga cggcaatctg gtgttcattt
     1801 acagccagga cgcttctgtt ttaaacggaa caatcggcga gatgcatgcg aagaagatcg
     1861 ctgcagtgta tgacatggcg atgaagatgg gagcaccggt gatcggcttt atcgattgcg
     1921 cgggagtccg tttacaggag tctgtagatg cgcttgacgg cttcggactg atctatgcaa
     1981 aagaagttgc agcatccggc gtggttccgc agatttcagc cgtattcggc aactgcggcg
     2041 gtggactggc agtggtaccg gcactttctg attttgcttt tatcgaagaa tccaaaggaa
     2101 agatgtttgt gaattctccg aacgcaattg acggaaaccg catcgagaaa tgcgacacat
     2161 catctgcggc attccaggca gatgagaacg gctgcatcga cgcgacggga acagaggatg
     2221 agatccttgc agacatccgt gagctggtcg gcatgcttcc gctcaacaac gagggagatg
     2281 tctacacaga cgagtgtgcg gatgacctga accgtgcatg cgagagcatg gatgccatga
     2341 agggtgatcc gagatatctt ctcagtgaga tttcggacag ccatacattc ttcgagacaa
     2401 aggcaggcta tgccagagat atggtgaccg gatttatcaa gttaaacggt atgacggtcg
     2461 gcgcagttgc aaactgcaca acggtatacg acgaagaggg caaagagagc gagaagtttg
     2521 acaatgttct ttctgcaaag ggatgtgaga aggcagcaga gttcgtatct ttctgcgacg
     2581 cattcgagat tccggtactg actctgacaa atgtcaaggg ctacaaggca tgcaagtgct
     2641 ctgaaaagcg tcttgcaaag gcacttgctc atctgacctc cgcatttgcg ggagctacat
     2701 gtccgaaggt gaacctgatc acgggagagg catacggtac cgcttatgtt gctatgaatt
     2761 ccaagtctat cggtgcggat ttcgtatatg catggccgga cgcgaaggtc ggcatgatgg
     2821 atgcggatct tgcagtaaag atcatgtacg cggatgcatc tgcggatgag cttgcagaga
     2881 aggcaaagga atatgatgca ctgcagggca gcgttatgac agcagccaga agaggctatg
     2941 tggatctgat cgttgatccg gcagatacga gaaagtatct ggtagatgcg tttgaactgt
     3001 tatacacaaa gtgtgcatat acaccggaca agaaacatgg aacaaaatag aaaggtgaag
     3061 tttatgaaga aaaaattatc tcttatactt tgtctttgct ttatggctct gggacttgca
     3121 gcatgcggaa cagatccgac aacggttgac tatttcggaa tgacttacga tgaactgcag
     3181 agcagcatgg aacaggaagt ttccgcgctg gttggtctta cggacgacaa cagaacctat
     3241 atccagtcct acggcagcga tacggcaatg aaacttgtcg agagttggga tgaggcgaca
     3301 agtgatgtcg gcgcatatca gggacttgga gaattcaata tcacaaaggc acagaaaacc
     3361 ttaacagtag atcagtatgt agagtatcag aatcgtgaag tcatcgtttc ttacatctat
     3421 acatacaatt acgagaccga gcagccggag cttactgatg catccgcgga caaggtatat
     3481 acgctgggtg agaagatgga gaaggctgcg ttaaataccc tgatgggaat gggaaccgta
     3541 ttcgtggttc tgatcctgat cagccttatt atttactgtt tccgctttat ctctgtaata
     3601 cagaacaagg tggccggcaa gggcaagaag aacgaggcag aggcaggcgc tgtggtagag
     3661 cagatcggac agcgtgaaga gcagcttacc gatgatcttg aacttgtggc agttatttcc
     3721 gcagcggttg cggcaagcac cggtgcatcc gcggattctt tcgttgtgag atcgatccgc
     3781 agacgctaat tcgtataaat gaaaagaaat catattagga ggatatttca atgaaaagct
     3841 atacaattac agtaaacggc aatgtatatg atgtaaccgt agaagagaac ggcgcagtga
     3901 gcgcaccggc agcagcaccg agacgtgcag cagcaccggc ggcagcacct gcggcaaagc
     3961 cggctgctgc agcaggcaca ggcagcgtta agattgaggc aggcgcagca ggaaaggtat
     4021 tcaaacttga gaagtctgtc ggtgatgccg ttaagaaggg agacagcatc atggttcttg
     4081 agatcatgaa gatggagact ccggtcgttg caacgcagga cggtacggta gcaagtatca
     4141 acgtaagtgt tggagatatg gtagaagcgg gcgcattact tgcaacatta aactaattta
     4201 ggaggaagac aatgagctat tttagtgaga caatggggaa cctcctgcat cagaccgctt
     4261 tctttaacct tacctgggga aattttgtga tgatcattgt cgcatgcttt ttcctgtatc
     4321 tggctatcgc gaaggggttt gagccattgc ttcttgttcc gattgcattc ggtatgctgc
     4381 ttgtaaatat ctatccggat atttttgcag acccggagca gatgagcaat ggtgtaggtg
     4441 gtttattcca ctacttttat gtgttagacg agtggtcaat cttaccgtct ctgattttcc
     4501 ttggagtcgg tgctatgaca gatttcggac cgctgattgc aaacccgatc agtttcctgc
     4561 ttggagctgc agctcagttc ggtattttcg gagcgtactt ccttgcaatc atgatgggct
     4621 ttaatgataa ggcagctgct gctgtttcca tcatcggtgg agccgatgga ccgacctcca
     4681 ttttccttgc cggaaagtta ggacagtcgg gactgatggg accgatcgct gtggcggcat
     4741 attcctatat ggcgcttgtg ccgatcatcc agccgccaat tatgaagctg tttacaacca
     4801 aaaaagagcg cgccatcaag atggagaact taagaccggt ttccaagctg gagaagattc
     4861 tcttcccgat cgtggttacg gtggttgtat gtacgattct tccgacgaca gcgccgctgg
     4921 ttggtatgct gatgcttggt aacctgttcc gcgagagcgg tgtggtccgc cagctgaccg
     4981 ataccgcatc caacgcattg atgtacatcg tagttatcct gctcggtact tccgtaggtg
     5041 catctacgag tgcggaggcg ttcttaaata caacgacatt aaagatcgtt gcacttggac
     5101 tgattgcatt tatgttcggt acagcagccg gtgtcctgtt tggtaagctg ttatgcttcc
     5161 tcacaaaggg caagatcaat cctctgatcg gatctgccgg tgtatctgcc gttcctatgg
     5221 cagcccgtgt atcccagaaa gtcggcgcgg aggaagatcc gacgaacttc ctgctgatgc
     5281 atgcgatggg accgaacgtt gccggcgtta tcggtactgc agtagcagcc ggtgtattca
     5341 tggcaatttt cggaatttag tgaaagagca aatgccgtca tagacggata gcggtatcaa
     5401 agtatccgct gataaggagg aaaaaatgtc agaagttgtt aaaaaacctt taaaaataac
     5461 agagacggtg ctgcgtgatg cgcaccagtc cctgattgcg acaagaatga caaccgagca
     5521 gatgcttccg atcgtagaca agatggataa ggtcggatac aatgcggttg agtgctgggg
     5581 cggtgctacc ttcgatgcat gccttcgttt cctgaaggaa gatccgtggg atcgtctccg
     5641 caagttaaga gatggattta agaacaccaa gcttcagatg ctgtttcgtg gacagaacat
     5701 cttaggatat cgtccgtatg cggatgatgt ggtagagtat ttcgtacaga aatcgatcgc
     5761 aaacggtatt gatatcattc gtattttcga ctgcttaaac gatgtccgca acctgcagac
     5821 agccgttacc gcatgtaaca aagagaaagg acatgcacag gtcgcattat cctatacact
     5881 tggcgatgcc tacactctgg attactggat ggagatggcg aagaaggtag aggatatggg
     5941 tgctgattcc ttatgtatca aggatatggc aggtcttttg gttccgacga aggcaaccga
     6001 gctgattcag gcattaaagt ctgcaaccaa ccttccgatc gagctccata cacactatac
     6061 ttctggtgtc gcttccatga catacatgaa ggcggttgag gcaggctgtg acattatcga
     6121 tacagcaatg tctccgttct ccatgggaac cagccagccg gcaaccgagg ttatggtaga
     6181 ggcattcaag ggcacagagt tcgataccgg tctggatcag aacctgttag ctgagatcgc
     6241 tgactacttc cgtccgatgc gtgaggaagc gttagagagc ggtctgatga acccgaaggt
     6301 tctcggcgtt aacatcaaga ctctgttata tcaggtaccg ggtggtatgc tatccaacct
     6361 tctgtctcag ttaaaagagc agggcaagga agacaagttc gaggaggttc ttgcagaggt
     6421 tccgcgtgtg cgtaaagacc tcggtgagcc gccacttgtt acaccgtcct cacagatcgt
     6481 tggtacacag gctgtgttca acgtactgat gggagagcgc tacaaagtgg caaccaagga
     6541 gaccaaagac gtactgcttg gaaagtacgg tcagactgta aaaccgttca acccggagat
     6601 cgtagacaag gtacttggcg aggagaagaa gaacgccatt acctgccgtc cggcagatct
     6661 gcttgagccg gagctggata agatcgaggc tgagatgaag cagtggaagc agcaggatga
     6721 ggatgtactg tcctacgcac tgttcccgca ggttgcaacc gaattcttca agtaccgtga
     6781 ggcacagcag aagaaggtcg atgcaagcgt cgcagatact aagaacggag catatccggt
     6841 ataatcaaaa aacagttata acaaaaagcg ggtgaccagt cacctgcttt ttttgctgcc
     6901 ttttttgcta ttttatcaca ccgcaggcaa tccgttcgcc ggagtcgccc gcgggctgcg
     6961 ttgtaaagtt atccggcatc cggtgaatga tgagggattt tccgataatt tccggaatcg
     7021 taaaacgctt gtcataaaat gccatccagg cataaccctg gttgcccaga agcggaggca
     7081 tgtcgccgct gtgattcggg tgttcggccg gcgtacggct gtaatgggca ccggcactgg
     7141 taaacgggga gacgcacacg ccgttttcgt ggatgtgcat gccgtaaaaa ttactggagc
     7201 cgggagtcgc gacgttcgga agaccgaaga cttcaacctc cacgagagtt ccttcgtatt
     7261 ttgtggcata gaaccgggca agcccggaga tggaaggaaa attgttgccg ccggcaatcc
     7321 aggcggatgc atccggcgga gactgcatca gtgtatgaat aaaattggtt gctggtgtga
     7381 tatcgcgcat agctgcctca atggaagagt gtcattggtt tattatatgc agcggcggaa
     7441 aaatgcgctg catgtgagga aagttccatg cataatttct tgcaaaacac catgtatttg
     7501 atataataaa aacattgagc ggatcacaat tccgcagaag tgaggagaag catgagcaat
     7561 acaaatgacc tgagtaaccg catcaatgat gcttacagta agctgagcaa gggacagaaa
     7621 cggctggcaa cctacattac ggacaattat gacaaggcgg tatttctgac cgctgcaaag
     7681 ctgggcgagg ttgtaggtgt gagcgagtcc acggtggtgc gctttgcaac gcatctggga
     7741 tataagggct atccggaatt ccagagtgcg ctggaggaac tggtgcgcaa taagctgaac
     7801 tccattcagc gcatggaggt tacttacggc aggatcagcc agtcgaagat tcttgagacg
     7861 gtgctgaaat ccgacgcgga caagattcat tccacactgg aaaagattga tcagaacgca
     7921 tttgaactcg cggttgacac gatcctgcac gccaaacata tctatatcat cggaatccgg
     7981 agctgtgcgc cgcttgccag cttcatggct ttttatttta ccctgatgtt tccgaacgtt
     8041 catctgattc agacaagcag ttcgagcgag atttttgaac agatggtgcg catcggcaag
     8101 gaggatgtga tcatcggaat cagttttccg cgttattcca tgcgtacttt aaaggcgatg
     8161 gaatttgcga ataaccggag tgcgaaggta atcacactca ccgacagcgt acattccccg
     8221 atgaacctct attcttcctg caatctgatt gcggacagcg atatggcttc cattgtggat
     8281 tccctggttg ccccgctgtc ggtgatcaat gcgctgattg tggcgctctg catgaaaaag
     8341 cagaacgagg tggcgaaaac gcttgagatg ttagaggata tctgggacga ataccaggtt
     8401 tacgagaacg atgagatcaa ttatatcgat gattccatca agatgcggta tggaaaagta
     8461 ggagatgcgg aactgtatga gtaaggtgat cgtagtcggc ggcgggccgg cgggaatgtt
     8521 tgctgccatt gcggcggcgg agcggggaca tgaggtcgtt ttgctcgaga aaaatgaaaa
     8581 gcttgggaaa aagctctaca tcaccggcaa agggcggtgc aacatcacga atgcggggga
     8641 tatggacacc ctgtttgcca atgtgatgac gaacccaaag tttttgtaca gcgcttttta
     8701 cgattatgac aatcagagag tgattgattt ttttgaggag aatggtctgg cgacgaaggt
     8761 agagcgcggc aaccgtgtat tcccggtatc ggatcattct tcggatgtga tcgccacgct
     8821 acagcgggta ctaaagcgca cgggtgttat ggtgcagctt catgcggaag tgcggcagat
     8881 cctcaccggg gaaggcgcgg tgcgcggcgt gaagcttgcc gacggaagcg ttcttgaagc
     8941 agagcgcgtg attcttgcaa ccggaggatt ttcttatcag acgaccggtt cgaccggaga
     9001 cggctaccgt tttgcgaggg aactcggaca tacggtgaca cagattacgc cgtcactggt
     9061 tccgttctac gtgaaggaga cctgcgcggc gaggatgcag gggctggcgc tgaaaaatgt
     9121 gcaggtgcgc atccgggacg gaaaaaagct gttgtatgac gaattcggcg agatgctctt
     9181 tacccatttc ggggtaagcg gaccgctgat tttaagcgcc agtgcggcaa tcaagccggg
     9241 ccgcgtggag aaggaactgg cgatggagat cgacttaaag ccggcactca cggaggaaca
     9301 gctggatgcg agacttctgc gtgaattcga ggaggcaaag aataagcagt ttaaaaacgc
     9361 cgtcgtgcat ctgttcccgg cgaagatgat tccggtgatg ttagaagccg gagcgattga
     9421 tccggagaag aaggtcaacg agatcacgag agaggagcgg atgggatttg tgcatctgat
     9481 caaggcgttt ccgctgacgc tctgcggtgt cagagatttc aatgaagcga tcatcacacg
     9541 cgggggtgtc agcgtaaagg aagtgaaccc ttccacgatg gaatcaaagc ttgtgccggg
     9601 attgtatttc tgcggggaac tattggatct ggatgcgatg accggcggat ttaatctgca
     9661 gattgcctgg tcgaccgggc atctggcggg tgagagtatc gaatagaaga ggagagaaga
     9721 agagatgagt atgaatattg cgattgacgg accggcaggc gccgggaaga gcacaattgc
     9781 gaaaaaactg gcgaaaaagc tggcgtttgt ctatgtggat acgggagcaa tgtaccgtgc
     9841 gatggcatac tattttttac agaacggcat tgcaccagat gatgagcagg cgattgcggc
     9901 agcctgcccg aaggttgacg tgacgattgt gtatgagaac ggcgaacagc aggtgctctt
     9961 aaacggagag aatgtaaacg gcgtcattcg gacggaggaa gtcggcaata tggcatcagc
    10021 gaccagtgtc tatccggttg tgcgcacaaa gcttgtggaa ctgcagcggc agcttgcgac
    10081 aaagacggac gtcatcatgg acggaaggga tatcggcacc tgtgtgcttc cggatgcgca
    10141 ggtaaaaata tatctcacgg caagcgttgc aacgcgcgca aagcgcagat atgatgaact
    10201 gaccgccaag ggaacccagt gcaatctgga agagatcgag aaagatattg aagaccgcga
    10261 ttaccgcgat atgcaccggg agacgtcgcc gttaaagcag gccaaggatg cggtgttagt
    10321 ggacagctcc gagatgaaca tcgacgaagt ggtggacgca atctatcaga tttatgcgag
    10381 ggtatagaga atatgaatgt aatcttggca aagagcgcgg gcttctgctt cggggtaaaa
    10441 cgtgccgtgg atacggtata tgaacggatt ttggaaaaag aaccgctcta cacgttcgga
    10501 ccgatcatcc acaatgaaga agtggtgcgt gatctggagg aaaagggcgt cgtcgtggta
    10561 aacgatgtgg acgaacttgc ggggaagccg caggggacgg taatcatccg ggcacacggc
    10621 gtggagagag gtgtctgcga gaaaatacag acgctcggct tttccatcgt ggacgcgacc
    10681 tgcccgtttg tgttaaagat tcaccggctg gtggagcgct acagtgggga ggactgtcac
    10741 attgtgatcg tcgggaatgc cagccacccg gaggtgaaag gcatcaaaag ctggtcgaat
    10801 gcagaggata cgcgcgtgat cggaacccgc gaagaggccg aaaaatacga tgcttcccat
    10861 gggaaaaagg tatgtattgt atcacaaacg acatttaatt acaataaatt tcaagaatta
    10921 gttgaaatta taaaagaaaa aggttatgat ataattgttt taaatacaat ctgcaatgct
    10981 acggaggaac gtcagacgga agcccgggta atcgcggagc aggtggatgc catgattgtg
    11041 atcggtggca ggaacagttc caacacgcag aagctatttg aaatatgtaa aaacgaatgc
    11101 aaaaatactt actatataca aactgtaaag gatcttgacc ttgccgaagt caggtctgtc
    11161 gataacgtag gtattaccgc aggggcttct accccaaaca atattattga ggaggttcaa
    11221 aagaatgtca gaaatgagct ttgaacaaat gctggaagaa tcatttaaaa caataagaaa
    11281 tggagaggta gttgagggta ccgttatcga tgtgaaacct gatgagatcg ttctgaatat
    11341 cggctacaag gcagacggaa tcattactcg taatgaatac acaaacgaag caaacgtaga
    11401 ccttaccaca ttggtatccg tcggcgacac catggaagca aaggttttaa aggtaaatga
    11461 cggtgagggt caggtattac tgacatacaa gcgtctggct gccgagaagg gaagcaagag
    11521 attagaggaa gcatttgaga acaaggaagt gctgaccgct aaggttgcac aggtactgga
    11581 tggaggatta tgcgtaaacg tagatgagac aagagtattt attccggcaa gtcttgtatc
    11641 agatacctac gagaaggatc tttccaaata caaggatcag gagatcgagt tcgttatcag
    11701 cgagttcaat ccgaagagaa gaagaatcat cggcgacaga aagcagcttc tggttgctaa
    11761 gaagttagag cagcagaaag aactgttcgc aagaatcaag attggtgatg tattagaggg
    11821 aacagttaag aatgtaacag atttcggtgc gtttattgat cttggcggag cagacggtct
    11881 gcttcatatt tccgagatgt cctggggcag agtagagagc ccaaagaagg tattcaaggt
    11941 aggcgatcag gttcgcgtat tcatcaaaga tatcaatgag aataagattg cactcagcat
    12001 gaagttcccg gcagagaatc cgtggaacgg cgcagcagag aagttcgcaa tcggcaacgt
    12061 tgtaaagggc aaagttgcaa gaatgacaga cttcggcgca tttgttgagc ttgcaccggg
    12121 tgtggatgca ctccttcatg tatcccagat ttccaaggag catgtagaga agccgtccga
    12181 cgtattaaaa gttggacagg agatcgaggc aaagatcgtt gatttcaacg aggaagagaa
    12241 gaagatcagt ttatctatga aggcactgct cgcaccggaa gaagatgcgg atgcagatgt
    12301 tgcagatgta gatattgatg cggttgcaaa ggaagaggag taatctctga tttcgatgat
    12361 tgcagagtta cagataggct tgcacgttgg tggaagccta tttctgtatt tgcatcctgt
    12421 agataacaaa gagagtcgag ggataaaata tgctggaaac ggacaattat gaaaagttta
    12481 aaaaggatat tttagcgctt gcaaagattg atctgaattc ttataaggaa aagcagatgc
    12541 ggcgcagaat caacacgctg attacgaaga atcatattgc gacatatgat gagtatgtgg
    12601 cgctgatcaa gaaggacaaa gagaagtttg aacagtttat caatttcctg accatcaatg
    12661 tgtcggagtt ttaccgcaat ccggatcagt ggaagattct ggagaatgag gtgttcccga
    12721 agctgattca gaagtttggc aagaatctga aaatctggag tgctgcctgc tcgaccggag
    12781 atgagccgta ttcgctggta atggcattgt ccagacacct gccgcttgca aacatcaagg
    12841 tgattgcgac cgacattgac aagcaggtga tcgatacggc gcggatggga ctctacaatg
    12901 agaagagtat cgcaagtgtg ccggatgatt tgaagaagaa gtattttacc aaggtcggca
    12961 attcgtatca gatctcggat gagatcaaga aacgtgtgga attcaaggag catgatcttt
    13021 taaaagatcc gtatccaggc ggatgcaatc tgattgtgtg ccggaacgtt gtgatctatt
    13081 ttaccgagga ggcaaaggac gagatttatg cgaagttcta taaggcgctt gcaacaggcg
    13141 gcgtgctttt catcggaagc acggagcaga tcatgaatta ccgggagatc ggatttgaga
    13201 gagacaagtc ctttttcttt gagaagacgg tatattatgc cgtaggcttc tccttgtgca
    13261 ttctcatacc gag
//
