LOCUS       c00078_gnlPro..        15628 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BNBIDJCA_78.
ACCESSION   c00078_gnlPro..
VERSION     c00078_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:23:07
            Original ID  :: gnl|Prokka|BNBIDJCA_78
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15628
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15628
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[20:5628]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      21..5628
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15628
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15628
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             21..1739
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-48, bitscore:
                     154.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTQKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             1757..2266
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_2"
                     /sec_met_domain="ALS_ss_C (E-value: 6.9e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKCYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(2335..3591)
                     /locus_tag="ctg78_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERAFNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             4354..5067
                     /locus_tag="ctg78_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAMKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     SPGGYRGDTRANAARILYLCQKYQLPVILSSDSHVKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             5269..5628
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_5"
                     /sec_met_domain="ALS_ss_C (E-value: 3.4e-22, bitscore:
                     68.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDKTFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFQAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVV
                     HGGSVGIESISMMER"
     CDS             6003..6638
                     /locus_tag="ctg78_6"
                     /transl_table=11
                     /translation="MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSHYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             6745..7710
                     /locus_tag="ctg78_7"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GNVSVDINMAGTLAAEVMAQAIQNAIHTSRIPDEEFLKYV"
     CDS             complement(8123..9307)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.4; E-value: 1.6e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg78_8"
                     /sec_met_domain="MFS_1 (E-value: 4.1e-25, bitscore: 78.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHTMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(9648..10412)
                     /locus_tag="ctg78_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             complement(10406..10603)
                     /locus_tag="ctg78_10"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLIVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             complement(10739..11425)
                     /locus_tag="ctg78_11"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             complement(11594..13012)
                     /locus_tag="ctg78_12"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVRPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(13266..13796)
                     /locus_tag="ctg78_13"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGGET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
ORIGIN
        1 caaaggaggt ttacccaaat atgaaacaaa tatccggcaa caaactctta gtcaaagcct
       61 taaaagaaga aggcgtagaa tacctcttcg gctaccccgg agcctgtacc atcgacatca
      121 gtgatgaact ctacaaacag gacgatgtca aaatcatcct cccccgtcac gaacaggccc
      181 ttgtccacga agccgacgcc tacgccagaa ccaccggcaa agtcggcgta tgtctggtaa
      241 ccagcggtcc cggagcaacc aaccttgtaa caggacttgc aaccgccaac tatgacagcg
      301 tacctcttgt atgcttcacc ggccaggtag cccgccacct catcggcaac gatgcattcc
      361 aggaagtaga catcgtagga atcaccagaa gcatcaccaa atacggcgtt actgtccgca
      421 gacgtgaaga ccttggcaga attatcaaag aagccttcta cattgcccgc accggccgtc
      481 cgggacctgt ccttatcgac cttccaaagg acgtaatggc agaactcggc agcgctgaat
      541 atcctaaaaa tgtaaacatc cgcggataca agcccaacac agatgtccac atcggccagc
      601 tcaaacgtgc catcaaactt ttaaataaag caaaacgtcc cttattcctg gcaggcggcg
      661 gtgtagtaat ctcccgcgcc catgaaattt tccgggaagt agtggaaaag acaaaagttc
      721 cggttgtcac aaccgtaatg ggaaaaggct ctatccccac agaccatccg ctctacatcg
      781 gaaaccttgg tatgcatggt gcctatgcag caaacatggc tgtcagcaac tgcgatgtgc
      841 tgttctccat cggaaccaga ttcaatgaca gaatcaccgg aaaacttcat gaatttgcac
      901 cacatgccca gattatccac attgatattg atacagcatc catttcccga aacattcagg
      961 tggatatccc cattgttgct gatgcaaaag aggctatcac caaaatgaac gaatacgtcc
     1021 aggaatgttc aacggacaag tggcttaacc tgatcaaaaa ctggaaagaa gagcatccgc
     1081 ttaaaatgcg tccaaatgat cttttaagtc cgatggatat cctgaaagag atcaacgaac
     1141 agtttgagaa cagtattatc gtaacagatg taggacagca tcagatgctt gtctcccagt
     1201 atgcggaaat cacagagggc aaacagatga tcatgtccgg tggtctggga acaatgggct
     1261 atggtcttcc aggcggcatc ggagccaaaa tcggaaatcc cgacagacct gtcatcgtta
     1321 tctccggtga cggcggtgtg cagatgaaca ttcaggagct tgcaactgca gttctggaag
     1381 aacttcctgt tatcctgtgc atctttaaca atgaatacct tggaatggta cgccagtggc
     1441 agaagctttt ttacggcaaa cgctatgcta tgaccaatct gcgcgcagga gcactttccc
     1501 gccgcactga aggcatggaa tatccacagt acacaccgga tttcatcaga cttgcagaga
     1561 gctacagggc aaaaggaatc cgtgtcacac agaaagagga aattgcagca gccttcgagg
     1621 aagcaaaaaa gaacacaaag gcacctacag taattgaatt catcattgac cctgaggaaa
     1681 tggtttatcc tatgatcaaa ccaggcggaa ctctggaaga tatgattatg gactgttgat
     1741 caggaggaaa attattatgg ataaaggaat gaaaaaaaga tggatttctc tctatgttga
     1801 gaaccaggta ggtgttctgt ccaaaatttc cggtcttttt tccggaaaat gttataacct
     1861 ggacagtctt acagtaggaa caacagaaga ccctacagta tcccgaatga cgattgcaac
     1921 tgtcagtgat gatgaaactt ttgaacagat caaaaaacag ttgaaccgta tgatcgaggt
     1981 tattaaggtt attgatttca cagacgtatt tgtccgcatg aaagagattc tgtatattaa
     2041 ggtttttaac tgttccaaag aagataaggt tgaactgttt cagattgccg aaaccttcaa
     2101 ggcaaaggtc attgactatg gcaaagacag cctgctcctg gaatttgtcc agacagcaac
     2161 caagaatgac gcagtagtga aactgatcaa ggaagaattt cacagaattg aagtggtacg
     2221 tggaggaagt gtaggaatcg aatctatcag tatgatggaa cgataaaact ttttctgaaa
     2281 tttttataaa gggaggattg tcgcattatt cttaatgctc agtcctccct ttacttacgg
     2341 ttcttccgtc ttttcgtttt tcatctgtgc ttttgctttt cgtccaatcc gtgcattgct
     2401 gttcataata ctggcacggg tgatcttatc atttccaaat ttcatccgga tctcatccat
     2461 agctgcatcc agctttctgt ggcgttcttt attttctgta tcttcaaaca gagacatctg
     2521 ttcataagtg ccatctgtaa ggcctgtcaa tgccacacca atcagacgta gcggctgccc
     2581 tttccagaat tctttaaaaa gtcttgtagc atttatataa atttcatctg taagatctgt
     2641 agcattttcc agctttgtct ggtgtgaacg gtttctgaaa tccaaagtac ggaaagtcac
     2701 ggaaatacag ttgcatttct tatcttttct gcgcattctg gttgccagaa catcacactg
     2761 ctccaaaagt atgggaaaca cctgctctat ggaagtaata tcatcgttaa aagtagtttc
     2821 cacactgaaa ccttttgcct catcaggcac tgcttttaca ggggaatcat caatacctct
     2881 ggcatattgc catagctgat gtcccgtttt ttccccaagc cagtactgca cattgaatgc
     2941 tctttctctt gccagatcac cgatggtacg gatcccctga ttcagaagct tctgctcgga
     3001 agcttttccc agaaacagca gattacggat aggaagaggc cacattttct ctggaatttc
     3061 atccggaaac aaagtgtgta ctctgtccgg cttctgaaaa tctgatgcca tctttgccaa
     3121 aagcttattg gtagaaattc ccacatttac tgtgaatccc agctctctgt gaatcttgtc
     3181 tttcagctca tgagcagcag ctacagggtc aggatagatc agagaagtac ctgtcatatc
     3241 cagaaatacc tcatcaatgg aaaaagattc catcacaggt gcaaaggaag cacagattgc
     3301 tttaaatgcc cgggaacatt tatcgtataa ttcaaaatca ctgggaacga tcaccaaatt
     3361 gggacatttc cgaagagcca tggctactgg ctcgccggtc tggatcccgt atttttttgc
     3421 agggatagat ttggcaacca cgatacctgt ccgtttcttt ggatctcctc ctacacagga
     3481 aggaatttct ctaagatccg gcagcccctg gctcaccctt ctggctgatt cccaggaaag
     3541 aaatgcactg tttacatcaa tatgaaaaat taaccgttcc gtacttttca ctgttcttcc
     3601 tccaatatat gaattgcgct cttcatatct gatgatttca ttttaccctg atctgctctc
     3661 cagggtaaga acctcgtttg tccaaaaaag tgtctttatt tgcatcatct tgtctgagct
     3721 gttactgtat ttatatttgt ttgatttcac tctgctatca gagttttgaa caacaacgcc
     3781 gcacttgcca tacggcagtg cggcgtctgt atttcgctac cggtcacatt gttcccggta
     3841 acttttttta cttaattctg aggattcatt tcctctcgat atatacttat cgattagtca
     3901 taaaggttag gagcaatttc ttcgctgtcc atatttgtgg aatcatacca gtatccagtt
     3961 cagcctccag ccattcataa gagaattccg ggaatgtctg atgtttgaaa tttttccatg
     4021 ttactccttt ctcatgaagt aactgtctac acataagcaa acagtgctat cgctgtcatt
     4081 gatcagcaat aagcccccgt gttttcatat agttccatta taccttctca ttttcccgaa
     4141 gtcaacataa tttaacatgt atcagccgtt tatttgtgtt gctttttatt tgatttttgt
     4201 tgtatttcag ttgtttttat tttgtttcct cattgacatt taaatcctca tctgtcatac
     4261 ttgaatataa cgaatgtacc atcaaacagc agctttgcat cttccgtaag gctcttatca
     4321 tatatagaaa ccgctctgga aaggagacaa acaatgtatc tttctgacat ccacacacat
     4381 tctatcgcca gcggtcacgg aaccacctgt accatctctg acatggcaaa agcagccagc
     4441 aaaaaaggac tgaaactcct tgggatttct gaccacggcc cgggaactct ggcttccgga
     4501 acttcttctt atttcagaag ccttcctttt tatcccagaa aaagattcgg catagatatt
     4561 ctttacggag ttgaactaaa catcctggac agtgcaggac atacagatct gtcagatgaa
     4621 ctgctgaaca acctggatta cgctatcatc agtatgcatc ggcagaacta ccgttcaggc
     4681 tctgtatctc agaatacaga agcttacatc aatgcaatga aacatcctgc tgtaaaaata
     4741 ctcggccact gcgacgatac acatttccct gtagattatg aaacgctggc aagagcagct
     4801 ttacgggaaa atgttatttt tgaaataaac gaagcttccc tctcacccgg aggatatcgg
     4861 ggagacacaa gagccaatgc agccagaatc ctgtatctct gtcagaaata tcagcttcct
     4921 gttattttgt ccagcgacag ccacgtaaaa gaacatgttg gagatttcac ctatgccgaa
     4981 gaattcgttc atcagctcat gtttccggaa actcttatcc ttaacaacca gcttcccaaa
     5041 ttaaaagttt tccttcagac acgttaaaag aatgttcctc aaagggacat tcttttattt
     5101 tatgcattgt tttttgcatt gtgttatttt gtttattttc tataatttct tgtcaaaaaa
     5161 gacgacattt tagtacattt taatcaacaa aactcactta accatttaca tatctcgtga
     5221 tagatcagtc ttactgtagg aaccaccgag gatcctacag tatcccgaat gactatcgca
     5281 acagtcagcg atgataaaac ctttgaacag atcaaaaaac aattaaaccg catgatcgag
     5341 gttatcaagg taatcgactt cacagatgta tttgtcagaa tgaaagaaat tctctacatc
     5401 aaggttttca actgctccag ggaagataaa gcagaactgt ttcagattgc agaaaccttc
     5461 caggcaaaag tcattgacta cggcaaagac agcctgcttc tggaatttgt ccagacagcc
     5521 accaagaatg atgcagttgt caaactgatc aaggaagaat tccacagaat tgaagtggta
     5581 catggtggaa gtgtgggaat tgaatccatc agcatgatgg aacgctaaat ctcataatca
     5641 atattttttg caggatatag aaacgtctct atatcctgta tttattttca aacatactat
     5701 aaaatattgc agtttttaat caaatgtgtt attgtttacg agagcgttat tcgaaagaaa
     5761 atgcatctgt tttccacatc tgacagtctg gtggataaag tcatccactt cacagtctgg
     5821 ttaaatttgt gaggcgacct gtaaggcgtc tacacaccga aaacttttac cggaagatat
     5881 ttcttgtttc atatcttttg ttctgatgta tatttttcat aacgcctgat ccccatactc
     5941 taaactgtct gaaaagcagg ggacgcattg cgccgtttta tcagaccaaa aggagaattc
     6001 atatgaacac aacaacaact actacaacag ctgccgcaaa aagaagcagc actctttaca
     6061 tggtagagtt ggctatgatg attgccatta ttctgctcat gtcctttacc ccgctgggct
     6121 atcttcgtac tcccggctta tccatcactc ttctcaccat cccggtagct gtaggagcta
     6181 tcatcctcgg accgaaaggt ggtgctgtat gcggacttgc tttcggtgca accagcttct
     6241 atatggctgt cacaggaagt tcagctttcg ctgccgcact ttttaacatt aatccatttg
     6301 gcacttttat tgtatgtatc gtggcacgtg tactggaagg atggatcaca ggacttattt
     6361 ttgcagcatt atataaatca ccggcgaaga aattttccca ttacgttgct tcactggcat
     6421 gcccattact gaatactttc ttcttcatgg gctttttatg tctcttcttc tacaacacag
     6481 attacattca gggtattgtt tccagtcttg gagtaagcaa tcctgttgtc ttcgttgctg
     6541 cttttgtggg cgttcaggga ctgatcgaag cgggcttctg ctttgtagtg ggaagcatcg
     6601 tttccaaggc actttctgtg gcactgaaac gtgcataatc tttaaaagaa cagcctttta
     6661 attctgctgt tccggaaggt tcactaaaaa tccctgacta cattgtcact gtagtcaggt
     6721 tttttttatc aaaaggagat ttttatgtca ttactaaaag agatttctat tacagagctt
     6781 tcaaatttac gcatcggtca tacttctgac catgatgcaa agaccggtgt aactgttctt
     6841 tattttccaa atggagcaaa agcaggctgc gatataagcg gaggcggccc tgcttccaga
     6901 gaaactcctc tcacctctcc tgtcactgcc gacaatccca tcaacgccat tgtcttgtcc
     6961 ggaggttctg cctatggact ggctgctgct gacggtgtga tgaactatct ggaatcacaa
     7021 aatatcggtt ataacaccgg tgcagccctg gttcctcttg tatgccagtc ctgtatctat
     7081 gacctctctt acggagatcc taaaatacgt ccaactgcaa aaatgggcga agaagcctgc
     7141 cgtcaggcat ttgcaggaac agataccaga accggaaata tcggtgcagg taccggtgca
     7201 actgtgggaa aactttacgg tatgaaacaa tccatgaagt caggtcttgg tattgccgct
     7261 gtatctgtga aaaatttcca gatggctgca attgtcgttg tcaatgcact gggagatatc
     7321 ttcagtccac aaaatggtca gaaaattgca gggctgaaaa cacctgacag aagcgggttt
     7381 ctggacagtg tccacgaatt ataccgcttt atgacacctc atgaccagtt taccggcaat
     7441 accaccatcg gagctgtaat caccaatggg gcattttcaa aggctgaact gaataaaatt
     7501 gcctctatga cccgctgtgc ctatgccaga tgcatcaatc ctgtagcaac tatggctgac
     7561 ggtgattcca tctatgctgc cagcattggc aatgtttctg tggatatcaa catggctgga
     7621 actctcgccg cagaagtcat ggctcaggct atccagaatg ccattcatac ttcccggatc
     7681 ccggatgaag aatttttgaa atatgtataa cagtccgcta taaaagcgca gagaaaaagt
     7741 atcatctctg cgcttttatt cttcctgtct gtcttcattt ttcatctgta ctctggtttt
     7801 tctccaagcc agagctgtac atttgcttcc cgttcccttg ccagatcacc aatagtacgg
     7861 attccctgat tcagaagctt ctgctcggag gcttttccca gaaataacag gttacggaca
     7921 ggaagtggcc acattttctc cggtatttcg tccgggaaca gcgtgtgtac tctgtccgtt
     7981 tctttggatt tcctcccaca caggagggaa tctccctgag atccggcagc ctctggctta
     8041 ctcttctggc tgactcccag gaaagaaatg cgctgtttac atcaatatga aaaattaatc
     8101 gttccatact ttttaatata tctcaatcat atttttgcag acttccaatc atcttaatcc
     8161 ccattatcat caacacaggg aaaatcagtg ccgcaaagat tccaagtttc agattatcat
     8221 tcagtgctcc tgaaatcatc cccacatagg ttggtccgga tgagcatccc acatctccag
     8281 caagggcaag gagggcaaac agggctgttc cgccacgctt tactgaggca gccgccatgc
     8341 tgaaggttcc cggccacata atacctacag acagaccgca aaccgcacat ccaaggattc
     8401 ccaacgcagg taccgggata aatgcgatca tcagatagga aaccatgcac agaactgcac
     8461 tgtattgcat aaagcgttcc agattgattt tatctccaaa tttcccataa aatgcccttg
     8521 agcttcccat aagaattgca aacgccatgg gacctgccag atctccgata gttttattga
     8581 ttccaaagct tttctcagcc agagtagaag cccactggct taccgcctgc tcactggctc
     8641 ctgcacagag catcattaac atcagaaccc agaagatttt tttcttaaaa agctctccca
     8701 tagtcagccc cttttcaccc tcatccagca gtggagcaat gggaactctg gtaaaaagga
     8761 ttccatttgc aatgggaatc aatgcccaca ccagcgccat atatttccag tttgcaatcc
     8821 cgaaaatacg aaagaataat gtagaaagaa gtaccactcc cacatgtccc caacagtaaa
     8881 aggaatgaag gagactcatt gctttttcct tattatctgt agggcaggct tccaccacag
     8941 gacttaccag cacctccagc aatccgcctc cgatggcata gatcataact gcaatgagaa
     9001 gtcccacaaa cggatctccc aggcactccg gcaatactgt gagcaaaatc agacctgcag
     9061 ccgccattgt atgtgccagg atcatagatg cacgataacc tattctgtcc acaaatccaa
     9121 tcgatgccag atctaccagc aactggattc cgaaattaaa agtaaccaga agtgtgatct
     9181 tctgcagcga aatcccgtaa ctgccctgaa atgtcagaaa cagcagagga acaaaattgt
     9241 ttacaatagc ctgcaccaca tatccgataa aacaggcctg cactgttctg ttgtaatttg
     9301 ttttcattca atatgatatc ctccaatctg aaatttatta gttactgaga acggagtaag
     9361 cagtaacaat ttattacgct gatatcgttc aggcattctc attcaccaaa ttctgcacct
     9421 tcacagttct atcaatcaat aatgacagtg tatcacagat tctttctttt ttctttcatt
     9481 atattttgaa aatcctataa atttttatgt tattttgact ttttctcata taacaattct
     9541 atacactcta acaggtaatc catcaatcca attcaaaata tttcccgcaa aaaaagatgt
     9601 gtaccatacc atttctgaca ccatacacat ctcaaaataa acacttctta tcttctgtac
     9661 tccgcagtca ggtctttaat aacctctcct gcaataatca gcccggcgac agacggcaca
     9721 aaggccacac tccccggaat atctctgcgc tccgtacact tatgcgcagc acccggagga
     9781 caaatacaat gcgacctgca gctgatcgcc atatcttcaa ttggtctgat cggctgttcc
     9841 tctgaataaa caaccttcag tttcttcaca ccacgcttct tcagctctct acgcataacc
     9901 ttcgccagcg gacacacctt cgtcttatag atatccgcca cccgaaacgc actggcatcc
     9961 agcttatttc cggcacccat actgctgata acaggagtcc ctgcctcctt tgcacgcatg
    10021 atcagttcaa tcttcgcagt cactgtgtcc acagcatcta ccacataatc atactcacta
    10081 aaatcgaaat cagcagcatt ctccggaaga taaaaacagt tatggattct cacatctgct
    10141 ttcggattaa tgtccaggat cctgtcccgc atcacctctg ttttatattg accaacagtt
    10201 ttcctggtgg caataatctg tctgttaaga ttcgtcaggc atactttgtc atcatcgatc
    10261 agatcaaagg tccccacacc gcttctgacc aatgcttcac atacatatcc tccaacccct
    10321 ccgattccaa acactgccac acgggagttc tccagtttat tcattgcttc ttttcccaga
    10381 agaagctctg ttcttgaaaa ttgattcaac ataatatctc catttcattc ggtattgacc
    10441 gactatctgc ctgcctttct tctacttcat tatttctggt ctgttctgct ttgctgcctg
    10501 taatgtaagc agctctgcat gccagaaaca aaaaaacaat gagcagaaac caaagccaga
    10561 gctttctttt gttttttatg agcaaccgtt tcataatctg catcactatt ccttaatata
    10621 ttattttcag ataccagagt tgcaacatac ttccatcaca gatttcttat gatatcttta
    10681 cttctataat gcgtcaagta tatcatagaa agaaaaatcc tgcaatgaag aaactctgtt
    10741 actgtacatg aagtgaacag tgctgagtga aattcacaaa ccggaagtgc ttatccatct
    10801 catcaccaat caatccaatt acttttccca tggtaaatgc cgccatcact gttccgattc
    10861 ccagtccgtt gatatgcccc aggatcagcc ctgtcataca ggcagtaatc atcagacaga
    10921 tcacatcaaa agaaaccttg atcttagaat atttcacctt tataatctct gacagttcac
    10981 gaggaaacag atctgtagga ataatcggca gaccgcatct gttagaaagt gcgatcccta
    11041 tacagatcag cagataactg atcacaaaat ataacactct gagtggaatt gtctttggca
    11101 ggatattgat ccatgcctca ttaacatcca aaagctcact gaatgcaaat ccaaccagaa
    11161 aactgcacag ataagcaggt acaaattttt ttctcagtat catcagactt aagatcagaa
    11221 gtgcctgaaa aatataagtc catgttccca gtgtaattac cggaaatact ttttcaaatg
    11281 cataaggaac actggatatg gcagatattc ctgaaccaga atacagcatc agaataacag
    11341 caagactgtt gatcatgact gctatcacca atgccagctc tcctctgaaa atatgtctcg
    11401 aatcttcttc ctcatttgtt ttcataacaa ttctctcctc taacacaagc aagggactgc
    11461 tgtcagaaaa tattttctgt catacttttc tgacggcaga cccctgtgtc ttttacatct
    11521 tatattttct gaaaatacta ttttttatcg aatcaggcaa gtttcccact tcaactactg
    11581 atattttcct gacttactca accgtgcaga cgcggatcag gtttgttctt cccggaattc
    11641 caagcggtac accaccggca aatacaatag tgtcgccaac ttttacaagt ttatgcttct
    11701 gtgctgcttc gattgctctc aggcaaagga tctcagaact gtattcttct ttgatcagca
    11761 tcgggtaaac accccaggac agattcagct ggcgaagaac tctctcagag cttgtacatg
    11821 caccgatcag acatcctggt ctgtgtttgg acatcatatg agctgtactt ccggattttg
    11881 tcactgcaag gattgcactg gccttcaagt cgattgctgt caggcaggtt gcatgtgcga
    11941 ttgcatttgt aatatccgga ttctcatttc tgtctgtttt cttaaagatt gtattgtaat
    12001 caatattctg ttccatatgt tctgcaatac ggctcatcat ctgaagtgcc tgtaccggat
    12061 atttaccagc tgcggtttct cctgaaagca tagttgcact tgttccctga aaaatcgcat
    12121 tggcaacgtc tgtagcctct gcacgggttg gtctcggatg agagatcatg gagtcaagca
    12181 tctgtgttgc tgtaataacc ggttttcctg ctgtgtaaac tttctggatg attttctgct
    12241 ggataacagg tacatattcc ggcgggatct caacacccat gtcacctctg gcgatcatga
    12301 tgccatctgc tgcttcaata atctcgtcga tattgtcaac gccctgctgg ttctcaatct
    12361 ttgcaatgat ctgaatctct tcaccgccgt tttctttcag gatttttctt acttcgcgga
    12421 tatcgtttgc agtacgtgta aaagatgctg caacgaaatc aaatccttcc tggataccga
    12481 agagaagatc atcatggtct tttttactga tgaatggcat cttcaggttt gcacccggaa
    12541 cattgacacc cttcttgtcg ccaatcacac ctgcattaat aaccttgcag acaatgtcct
    12601 ttcctgagat gtcctgaacc tccaggtcta caagtccatc atcaaccaga atatgtccgc
    12661 ccggccgcac atccttataa agctctttat aagtaatgct tacgcactca ttagttcctt
    12721 caatatcttt atttgtaaat gtaaatatct gtccttcttc cagagaaacc ttgccatcct
    12781 tgaagcatcc aagtctgatc tccggtccct ttgtatcaag aagtgctgca acaggtctgt
    12841 catatttctt gcgaagttct ctcagtttct ggatacggcc tctctgctca tcgtgaggtc
    12901 catgtgagaa gttgaaacgt gctacgtcca ttccctctct cacaagctgc tccataacat
    12961 cgcccttatc agtagacggt cccattgtac agataatttt ggtttttctc atttaatctt
    13021 tccctccaaa ctgtcaactc aattttatct attttattcc tgtaaaataa tgtaataaaa
    13081 tgttacctgt ttctataaat gaaaacatta aatcaaataa aaattaccat tattgagact
    13141 atctgtcaat atagaatttc gacttatttt tgttgatatt tgacaaaaaa ataacatact
    13201 tttgttgcaa atatcacata tatttttact gatccgacag ttggaaaatt tttcactcat
    13261 tcttatcaga atccaaaatc tgcatagtct tccggcagaa atctgtggta aatgatatgg
    13321 catccttcat ctttaaaaca ataataataa ggatctgatc cgtcatcaaa gcggatcatc
    13381 acatcaaact cctcgttatc cattggttca gtaatgattt tatctgaata agaatggaac
    13441 agttctttaa tttcctctat cgtacatcca tgtctgccaa ccagttcgat caatgccttg
    13501 ataaattcat tctctttcat attattatgt acatattcgg aagctttttc cgaaacagtg
    13561 aagcagaaac gatctcctct gtgtgatact gctacttcac caaatttctc ttctatataa
    13621 gaaggaaaat cttttaaaat ctccatcatg cctgcagcat ctgtctcacc gccaaagaaa
    13681 tgattcaggg aactgagcgg ataataaagg ctgatcttct ctttcatata tccaagcttc
    13741 gcctgttcct ctttgatcac atcgatcaga ctggtttcta atctgttata gttcatttat
    13801 tttccctcct gaaaatctgt tcttttgctt tttctggtta atattttatc agacattgcc
    13861 tgaaaatcaa tgcatttctt tttcaattgt acgcctgtca aaacaatttc aatgttttct
    13921 ttttcataca aaaataaaga ccttgcgaaa ctgtcctttt tttctccctc tgacaaatca
    13981 ctctggctga atgaaacaaa gcagacaaaa ccatcccctt cgttgctttt ttaaccaaat
    14041 aactgcttga ttcggttaaa aaaacagcgt tccaaatatt atttatatcc gaaacgctgt
    14101 cattattcca attatttcat tatgtattta atcccagttc ttacgtccgt aacgaagtgt
    14161 cacatcatat atttccttct ggagtttctt tgtaagatct ctcttcttga ttctccactt
    14221 ccagttcgta ccaactgtag atggtttatt cattcggaat ctgttgtcca gtcccatata
    14281 gtcctgcatt gggataacgc agacacgcgc agcactgcgc atgatcagac tgatgaaaca
    14341 cttatacagt tcttcttccg gtgttgcatg atcacacaga taatctctcg ccagttttct
    14401 ctcagctgct gtgatgctct tccaccatcc cacgatagtt tcattatcat gggttcctgt
    14461 atacgccacg cagttctccg gatagttatg tggcagataa tcactggcac atccggaatc
    14521 tctggagtca aacgcaaatt ccagaacctt cattcccggg aatccgctct catataccag
    14581 atgacgtacg gaatctgtca tatatcccaa gtcctctgcg ataacctgct tccatccaag
    14641 cgcctgttca atcttacgga acagatcaat tccgggaccc ttttcccagt gtccgcctct
    14701 tgcatcttta tctccgtatg gaatagagaa atattcatca aatccacgga aatgatcgat
    14761 tcgcacaaca tcatacagtc tgaagcagta actcattctg gaaatccacc actgatatcc
    14821 tgtatttctg tgataatccc agcgatacag cggatttccc cataactgac cggttgcaga
    14881 aaatccatcc ggagggcatc ctgctactgc cagcggtaca ttgtcctgat ccagctggaa
    14941 caactccgga tgtgcccatg catcagcact gtccatggca acataaatcg gaatatctcc
    15001 aatgatctgg attccttttg aatttgcata ggatttcagt ttcatccact gctcataaaa
    15061 cttaaactgc atatactgct ggaattcaat atcaaaatag agttcttcac gataataatc
    15121 catggcattg ttccagcgga gtctgatatc ctcagcccat ttggtccatt ctacaccttc
    15181 gaaacggtct tttactgcca taaacagagc ataatctgac agccaccagc tgttctctgc
    15241 tacgaatttc tgatagtcag gattcttgct gatatcactg ttctcgtatg cttttctcag
    15301 aagaggataa cggcctttgt agattttttc ataatctacc tcatcaggct tctttcccca
    15361 attaactttc tcgcagtctt tcttatcaag aactccttct tccacaagtg tatccagatc
    15421 aataaaatat ggattacctg caaatgtaga gaaagactga tatggagaat ctccatagct
    15481 ggtcggtccc aatggcagaa tctgccagta agtctgtccg gcttccttta accagtctac
    15541 aaattcatat gcacttttgg aaaaacatcc gatgccatag tctgatggaa ggctgctgat
    15601 cggcattaat attcctgctg ctcttttt
//
