LOCUS       c00065_gnlPro..        14258 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BNAIKFLL_65.
ACCESSION   c00065_gnlPro..
VERSION     c00065_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:27:03
            Original ID  :: gnl|Prokka|BNAIKFLL_65
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14258
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14258
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3418:6867]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3419..6867
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14258
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14258
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             219..605
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="MLFNGFDMLFNIAFALIFCSVFIILAYGIITSITTWNKNNHSPRL
                     NVSARVVAKRTEVSHHQHPNNGDMSGSHGYRTTSSTSYYVTFEVDSGDRIEFSMSGSEY
                     GMLIEGDAGTLNFQGTRYLGFERK"
     CDS             795..1649
                     /locus_tag="ctg65_2"
                     /transl_table=11
                     /translation="MKTKTDYKSILIEINILTIAIAIIAVAVYFFLVPSHTSISSMSGL
                     GIVLSNFVPLPLSAITMILNVVLLIIGFFTCGKEFGLKTVYTSVMLPVFLGIFENIFPN
                     IGSITDSQELDVLCYILVVSVGLSILFNRNASSGGLDIVAKIINKYFHMELGKAMSLSG
                     MCVALSAALVYDKKTVVLSVLGTYFNGIILDHFIFDHNIKRRVCIITKKEEELRQFIVR
                     DLHSGATIYEAIGAYNMEKRNEIITIVDKGEYQKLMKYINQEDPEAFITVYTVSDMRYL
                     PKK"
     CDS             1720..3045
                     /locus_tag="ctg65_3"
                     /transl_table=11
                     /translation="MKLTWSEASVFAFVWACALGYIVASRILEWNFERFLPSNWYFVVK
                     KRLAQPEAKFLRTEKVPKKISNVLEELLTLMQTGNLQKSTVRMDRTFQKKVMHEVKLLE
                     GRGLSRQLHFTNVKLSEGNAKKRDFRHWSDSGREWREVIVEAAVSDKYLHRDSGKVIHE
                     SIYPHGSILLRQSRHIRHNEVGEKDRQKEQRFYSKYSEIFCPSCGAQIQLKGDETNCPY
                     CGGFIQSNFYDWQIEDFMIYQTPDPNMDNLKYTSVTILLSFLPTFPCVYLITNMYIAIG
                     VAMTLTIILSLSLLWIRARKIDELENLEKEIVRYDEGWLISNINEALYKTLLTPELLSY
                     SVNNIKLKGVENTSDKTTIFVEAMLKQTFLQNNKHIVTKSEKHNWKLCRSRYPNRIKSK
                     GQAVVMEKECPSCGANYIPDNNGCCSYCGYSLQVDNAKWKLL"
     CDS             complement(3154..3426)
                     /locus_tag="ctg65_4"
                     /transl_table=11
                     /translation="MIKGGLKYYILFENYEQGLALHDVLDSDDIPNRIAPAPRAIQGEL
                     SCGMSLLIEPAHIEQVRLSIEKHQAEYHTIVPLEGQVKPKRDKYC"
     CDS             complement(3419..4693)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_5"
                     /sec_met_domain="HGD-D (E-value: 7.8e-89, bitscore: 288.5,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDYVSMWKDLGMDLENHDLLCQVLPTAVGDVFLSQENRPKAMDF
                     WDLVISEVHGIRPAELIKEQEKGRKVFGTFCVYVPDEVVIAANGIVTGLCGGSQFWVPD
                     GEKVLPKSTCPLVKASVGARLGRTCPFFRIADMYVGETTCDAKKKAYEILGEDVPMHIM
                     DVPQMKRTKDIVKWKEEIADFAKVVEEFTGNAITPEKLSEAIHIVNEKRKAMQRVYDCR
                     KSECLPISGRDVLLMTQISFFDDPVRCAEMCNRLADELEQRIKDGVSVVKEGTKRILVT
                     GTPMAVPNWKLHNIIETSGGAVVCEEMCTGTRYFENFVDESKTTLDEQFMALSERYMKT
                     NCACFTPNTGRIDDLLRMVKEYKIDGVIDCSLKFCCLYDTEKYSVSRALKEAGIPVLSL
                     ETDYADTDAEQLRTRIGAFIEMLND"
     CDS             complement(4904..6037)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_6"
                     /sec_met_domain="Aminotran_5 (E-value: 4.1e-93, bitscore:
                     302.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIYFDNAATTLHKPHEVIEAVVHAMTTAGNASRGTHTGSLAASRT
                     VYETRKKIADFFHCSRADHVIFTSNSTEALNIAICGTLGKGDHIISTDLEHNSVLRPLY
                     HLEEQGASLTFLSANKKGCIDYDDFKRSIKPNTKAIVCTHASNLTGNVLDIERIGRIAK
                     AHNLLFIVDASQSAGCIEINMETMNIDILCFTGHKGLLGPQGTGGLCIHESVEIRPFKH
                     GGSGIHSYEKGQPQAYPARLEAGTLNSHGIAGLCAAINYINTITIPVIAKKEQELLWHF
                     YKGICNIPEIHIYGDFDTKERAAILSLNIEGYDSGTVSDLLSQEYDIATRPGAHCAPRM
                     HQALGTTETGAVRFSFSSFNTMEEVETAIQALKELVE"
     CDS             complement(6094..6867)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_7"
                     /sec_met_domain="BcrAD_BadFG (E-value: 7e-52, bitscore:
                     166.5, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKYFIGIDIGSTCAKTVVMNHEKEILHRFLQPTGWSSVDTAKQI
                     QETLMEKGILPEKSVVVATGYGRVSVPYAAKCVTEITCHAKGACYIHKNENMLLIDIGG
                     QDTKIIRIENDMVTDFLMNDKCSAGTGRFLEVMANTLSLTPQDLCELASKGSGTSISSM
                     CTVFAESEVISLIGRGESRENIAFAVIDSIVQKVVSQAARLTNGQEECICLTGGLCDYS
                     YLKKSLGESLKTDVLTDTDGRYAGAIGAAIAATTI"
     CDS             complement(6909..7148)
                     /locus_tag="ctg65_8"
                     /transl_table=11
                     /translation="MLRKKKPAFIIAFDATTQAMATDKLCAKNGLPGRLIPVPREITAG
                     CGFAWKAAPEDETILIEALTKEGIEWASTHILEI"
     CDS             complement(7165..7797)
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MIKVNAMGDACPIPVVKTKNAIRELQGGGTVETLVDNEIAVQNLT
                     KMANQKGYDVHSEKVADNEFKVTMTINAEAAQIAANSAVATIEEENCPITPLNKKNTVV
                     VIRSNQMGNGEEELGKALLKGFIYALSQQDTLPSTILFYNSGAYITCEESASIEDLKSL
                     EAQGVEILTCGTCLNFYGLTDKLQVGEVTNMYVIAEKMTQADLIVQP"
     CDS             complement(7997..9025)
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MEKEKLFCKGGGCTAKLGAGILSRILSKLPQGPEDENLLVGYDSK
                     DDAAVYKISDDIAFVQTLDFFPPMVDDPYTFGKIAATNALSDIYAMGGEVKTALNIVCF
                     PEKMDLNILGEIMRGGAEKVIEAGGTLAGGHSIADSDVKYGLSVTGIVNPNKIYTNNGA
                     KPGDALILTKRLGVGIICTANRVGEASVEAMKAVTDSMTTLNKYAAECCRNFEIHACTD
                     VTGFSFLGHLHEMMDGQLSCHIHAGQVPVFEEALRHADEFLLTAAGQRNRNFTGPFVQF
                     EDIPFAMEEILFDPQTSGGLLISLAKEDAPALLGKLKASGLPAEIVGEVLEKAEPEILV
                     TN"
     CDS             9369..10280
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.2; E-value: 2.3e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg65_11"
                     /sec_met_domain="LysR_substrate (E-value: 2.5e-31,
                     bitscore: 98.6, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 5.6e-20, bitscore: 61.2,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIHQLQIFANVAECKGFLAASKKMHLSQSTVSTHVSALEHELGK
                     KLIRRTARNFELTEDGVKLYKYAVDILLLHRKAIMEVGGNGSEFLRIGTSSVPAQWFVP
                     TILSGFLKKNVNTQVEMTSADSLDIIRRVKEGSLDIGFVGTKVEKQCKYISLVNDHLVL
                     AAPNTKKYQKIFVGESGSGESDLRQILESPFLARRQYSGTMKEALGSLEYFGIKEEDLN
                     IVATFDSAEMLRDCVEAGMGISILSYEMIKELHERGKILIYRLPEKEFCRELYLIYKNE
                     SFLPEIVKKFIHYTEKYFKKEF"
     CDS             10371..11045
                     /locus_tag="ctg65_12"
                     /transl_table=11
                     /translation="MYRILIVEDDSTIALNMAAHLERWDYETKQIEDFKCVMEVFQQFD
                     PQLVILDIGLPFYNGFYWCQEIRKISSVPILFLSSMNDNMNIVMAMNMGGDEFIEKPFD
                     LNVLTAKVQALLRRAYSFQGNVNVLEHEGMLLNLNDASLSYKGEKISLTKNEFRILQML
                     MENAGKIVARDDIIARLWESDEFIDDNTLTVNVARLRKKLENAGMEGRIKTKKGIGYYL
                     DK"
     CDS             11061..12074
                     /locus_tag="ctg65_13"
                     /transl_table=11
                     /translation="MIKESIFSFLKIRKVLIIIFIGIVVIFGILFYLYDIPFDAIIYGC
                     ELSFVWCAVCLFIDFYKYYKRHKLLHINREQFFDDAEQLPEHMDIIEYDYQELAKKLYQ
                     AKQELISKNRIAKKELLDYYGMWVHQIKTPIAALDILLQNTERMLYQLDEKEMMQKAIS
                     VSDMKMELFKIEQYVEMALNYLRVEDISSDLVFKKHELDDMVRQVIRKYAKIFISKKIK
                     IDFKLTKACIVTDEKWFIFVLEQIISNALKYIKKGQIFIYMKKKSLVIEDTGIGIPAED
                     LPRIFEKGFTGYNGRENKKSTGIGLYLCKNIMDKLQWNITVDSEVGSGTKIYLTKM"
     CDS             12178..12945
                     /locus_tag="ctg65_14"
                     /transl_table=11
                     /translation="MALLDVKNVRKVYTTRFGGNQVEALKDVNFSVEQGEYVAIMGESG
                     SGKSTLLNILAALDKPTEGKVFLKEKDLSKVKEKEMAAFRRNNLGFVFQDFNLLDTFSL
                     KDNIFLPLVLSGTSHKEMERRLLPLADKLGIKNLLEKYPYEVSGGQKQRAAVARAVITQ
                     PQLLLADEPTGALDSKAAKELLKLFTSLNQDGQTILMVTHSVKAASTAGRVLFIKDGRV
                     FHQIYKGNLSETQMYQKISDAMTAITAGGADDE"
     CDS             12935..14257
                     /locus_tag="ctg65_15"
                     /transl_table=11
                     /translation="MMNSKIYGKLAVTNLKNNKKSYIPYILASAFSVMMYFTMDNLYRN
                     RSLVEKGSPLAIMLSYAAAVILIFSIIFLFYINSFLIKRRKKELGIYNILGMGKGHLGK
                     MLFLESVITTAASIIGGILAGILLGKLVYLILLKILHMGGKIEYRISLASIGMTTIFFG
                     AIFILIFLYNLLQMKLSNPIELLRGGNTGEREPKTKWIMTIIGILCLAGGYSIALITKE
                     PMAALGKFFIAVILVIIGTYALFMAGSIAFLKMLRNKKSYYYKTRHFTAVSGMIYRMKQ
                     NAVGLANICILSTMVLVMVSMTVSLYGGLNDVIVTRFPYEAQITSSGINQKEEGQIEEI
                     IKNMTKKNHTMPTSQIRFHVGRFTTVYNNKTKKLDMMAAGDYTNSNTVDLVMIPLSDYN
                     QTEGKNVKLKENEVLLYHRNHKRTHKKSDTEALKNKKVIQLN"
ORIGIN
        1 atatatatcg taccgcaagg tacttgtgtt caagcgtaag attcacccca gaaactaatg
       61 tttctggggt ttttctgttg cctgggaaaa taggaatttg ctggggacgt ccgtttactc
      121 cctcggcaaa ttcctatttg aagttataat tgctgtatga taaaattatc gtaaaacaca
      181 tatttctaag aggagaaaat atgagaagga gaaacactat gttatttaat ggatttgata
      241 tgctatttaa catcgccttc gcactaatat tctgtagcgt ttttattata ttagcatatg
      301 gcattatcac aagtattacc acatggaata aaaacaatca ctctccacgg ctcaatgtat
      361 cagccagggt agttgctaaa cgaacggaag tctcccatca tcaacatcct aataatgggg
      421 acatgagcgg ctctcatgga tatagaacta cctcatccac ttcctattat gtaactttcg
      481 aggtggacag cggtgataga atagaatttt ctatgagtgg ttctgagtat ggaatgctaa
      541 tagaaggaga tgctggaaca ttaaattttc aagggacaag atatcttgga tttgagcgca
      601 aataaagaca taagagctat taaaaataag cagtttctaa cagaattatt taataccatg
      661 tatagcgaat ggatagttcc aaaattcaat aagaaaaata aatgaaggaa aatgatgttt
      721 ttaatcatca gctcaattat actttttatt catgcagtaa tagtctttaa cacaggagga
      781 gataaaaaaa taatatgaaa acgaagacag attacaagtc tattttgata gaaataaata
      841 tccttaccat cgcaattgct attatagctg ttgctgttta cttttttctg gttccgagtc
      901 atacgtcgat tagcagtatg tcaggtctgg gtattgttct gtcgaatttt gttccgctgc
      961 cattatcagc gattacgatg attcttaatg tagttttatt aattattgga ttttttacct
     1021 gtgggaagga attcgggctt aaaacagttt acacaagtgt tatgctaccg gtgtttctgg
     1081 ggatatttga gaacattttt cccaatatcg gttctataac agatagtcag gagctggatg
     1141 tcctttgcta cattctggtg gtgagtgtgg gtctgagtat tttattcaac cggaatgctt
     1201 cttctggggg attggatatt gtagctaaga ttataaataa atattttcat atggagctgg
     1261 ggaaagcgat gtctttgtcg gggatgtgtg tggcactttc ggcggcgctg gtttatgata
     1321 agaagactgt agtactcagt gtattgggaa cttattttaa tggtattatt ttggatcatt
     1381 ttatttttga tcataatatc aaacgacggg tctgtatcat tacaaagaag gaagaggaat
     1441 tgcggcagtt tattgttcgt gatctgcaca gtggggcaac tatttacgaa gcgattggtg
     1501 cttacaatat ggaaaaaaga aatgagatca ttaccattgt agacaaaggg gagtatcaga
     1561 aattgatgaa gtatatcaat caggaagatc cagaggcatt tattacagta tatacggtat
     1621 cggatatgcg gtatttgcct aagaagtaga agaatttgag cattgaggga aaagggtgtt
     1681 gctgtagtaa tctacggata tatgaggagg tgatttttga tgaaacttac atggagtgag
     1741 gcgagtgttt ttgcttttgt gtgggcttgt gcattagggt atattgttgc aagccgtata
     1801 ctggagtgga attttgaacg atttttgcct agtaactggt attttgtggt gaaaaaaaga
     1861 ttggcacaac cggaagcgaa gtttttgaga acggagaaag taccgaaaaa gatatcgaat
     1921 gttctggagg aactgcttac tttgatgcaa accggtaatt tgcaaaagag tacagtaaga
     1981 atggatcgga cttttcaaaa aaaagtaatg catgaagtaa agctgcttga aggaagaggt
     2041 ttatcaaggc agctacattt tacgaatgtg aagttatcag aagggaatgc caaaaagaga
     2101 gacttccggc attggagtga ttcaggacgt gaatggaggg aagttatcgt agaagccgct
     2161 gtttctgata aatatttaca tagagacagt ggtaaggtaa ttcatgaatc gatttatccg
     2221 catgggtcga tattgcttcg gcagtcccgt catattcgtc acaatgaagt gggagagaaa
     2281 gacaggcaga aggagcagag attttactca aagtattcgg aaatattttg tccaagctgt
     2341 ggggcacaga tacagttaaa aggtgatgag acaaactgtc cttattgtgg agggtttatt
     2401 cagagtaatt tctatgactg gcaaatcgaa gattttatga tttatcagac accagatccg
     2461 aatatggata atctaaagta taccagtgta acgattttac tttcgttttt accgacattt
     2521 ccttgtgttt atttgatcac gaatatgtat attgcaattg gtgttgcgat gacacttaca
     2581 attatactga gtctgagtct tctttggatc agagcaagga aaatagatga gctggagaat
     2641 cttgagaaag agattgtccg ttatgatgag ggctggttaa taagtaatat caatgaagcg
     2701 ttgtacaaaa cacttcttac cccagagctg ctttcttaca gtgttaataa tataaagcta
     2761 aaaggtgtgg aaaatacgtc tgacaagacg acgatttttg tggaagcgat gttgaagcaa
     2821 acctttcttc aaaataataa gcatatcgtg acgaaaagtg aaaagcataa ctggaagctt
     2881 tgccgatctc gttatccgaa tcgaattaag tccaaaggcc aggccgttgt gatggaaaag
     2941 gaatgtccaa gttgtggggc taactatatt ccggataata acggttgttg ttcctattgt
     3001 ggttatagtc tgcaagttga taatgctaaa tggaaattgt tgtaataagt ttttgtatat
     3061 atatcgtacc gcaaggtact tgtgttcaag cgtaagattc accccagaaa catttgtttc
     3121 tggggttttt ctgttatcta gaaaaatagt aattcaacaa tatttatctc gctttggttt
     3181 tacctgtcct tcgaggggta cgatggtatg gtattctgct tggtgctttt caatggaaag
     3241 tcgtacttgt tctatgtgag caggttctat gagaagggac ataccgcagg ataattcacc
     3301 ctgaatggct ctgggagccg gggcaatacg gtttggaatg tcatcggaat ctaagacgtc
     3361 gtgaagggca agtccctgct catagttttc gaataagata taatatttta atccgccttt
     3421 aatcattgag catttcgatg aaagcaccaa tacgagtacg aagctgttca gcatctgtat
     3481 ctgcatagtc agtttctaag cttaagacag gtatgccagc ttcttttaaa gcgcgggata
     3541 cggagtattt ttcagtatcg tagaggcagc agaatttcaa gctgcaatca atgacaccat
     3601 ctattttata ttcttttacc atacgtaaaa ggtcatcaat acgaccggta tttggcgtga
     3661 agcaagcaca atttgttttc atgtaacgct cagataatgc catgaattgt tcatctaaag
     3721 ttgtcttgct ttcgtctaca aaattttcga aataacgtgt tccggtacac atttcttcac
     3781 agacaacagc acccccgctt gtttcaataa tattatggag tttccagttt ggaacagcca
     3841 taggagttcc ggttacaagg atacgttttg taccttcttt gacaacagat acgccatctt
     3901 tgatacgctg ttctaattcg tctgcaaggc ggttacacat ttcggcacaa cgaacgggat
     3961 cgtcaaagaa agaaatctgt gtcataagta aaacatctcg cccggagatt gggagacatt
     4021 ctgatttacg acagtcatac acgcgctgca ttgctttacg tttttcattt acaatgtgaa
     4081 ttgcttcgga aagtttttct ggagtgatag cattacctgt aaattcttca acaacttttg
     4141 caaagtcggc aatttcttct ttccatttta cgatatcttt cgtacgtttc atctgaggga
     4201 catccatgat atgcattgga acatcttctc caagaatttc gtaagccttt ttcttagcat
     4261 cacaggtagt ttcaccaaca tacatgtctg caatgcgaaa gaatggacaa gttcttccaa
     4321 gtcttgctcc aacagaagct tttacaagtg gacaggtact ttttggaagt actttttctc
     4381 catctggaac ccagaattga gacccaccgc aaagacccgt tacaattccg tttgcggcga
     4441 taacaacttc atctggtaca tatacacaga aagtaccgaa aactttacgt cctttttcct
     4501 gctccttaat aagttcagca ggtcggatac catgtacttc agagatgact aaatcccaga
     4561 aatccattgc ttttgggcga ttttcctggc tgagaaaaac atcacctact gcagtaggga
     4621 gtacctgaca taataaatcg tgattttcga gatccattcc aagatctttc cacatagaaa
     4681 cataatctga cataagtaaa atacctctct ttttttattt taatgtattt ttagaagtaa
     4741 gtctgtttga aaagttattt tggcaatata tatgctttta tgaactttac aaaaacaggg
     4801 taaattctaa aagtacattg tattctgtaa gttgttttat aagtttttta gtagctatag
     4861 cacagtcatt tacagattca gtcaatatag ctttttaaac ttattactct acaagctctt
     4921 ttagtgcctg tatcgcagtt tctacttctt ccattgtatt aaacgaggaa aagctgaaac
     4981 ggacagcacc cgtttctgtt gtgccaagtg cctgatgcat tcttggggca caatgtgcgc
     5041 ccggacgggt ggcaatatcg tattcttggg acagcaaatc agatactgtt ccagagtcgt
     5101 aaccttcgat atttaaagaa agaatagcgg ctctttcttt tgtatcaaaa tctccgtaaa
     5161 tatgtatttc gggaatattg caaatcccct tataaaaatg ccataatagc tcttgttctt
     5221 ttttggcaat gacaggaata gtaatagtat taatgtaatt aattgcagca caaagtccgg
     5281 caataccgtg gctgtttaat gttcctgctt ctaaccgggc aggataagcc tgtggctgcc
     5341 ctttttcata agaatggatg ccggaaccgc catgtttaaa tgggcgaatt tcaacacttt
     5401 cgtggatgca taagcccccg gtcccctgtg gaccgagcag acccttatga ccggtaaagc
     5461 ataaaatatc aatattcata gtttccatat taatttctat acagcctgca ctttgagaag
     5521 catcaacaat aaaaagaaga ttgtgtgctt tcgcaatacg accaattctc tcaatatcta
     5581 aaacatttcc ggtaagattg gaagcatgtg tgcagacaat tgcttttgta ttcggtttta
     5641 tagaacgttt aaaatcatca taatcgatgc atcccttttt attggcagaa aggaaagtaa
     5701 gggatgctcc ctgttcttcc agatgatata agggacgtag tacagaatta tgttctaaat
     5761 ctgtcgatat gatatggtcc ccttttccaa gtgtaccaca gatagcgatg tttaatgctt
     5821 cggtagaatt cgatgtgaaa atcacatgat cagccctgga gcaatgaaaa aaatcagcaa
     5881 tcttttttct tgtttcgtaa acagtgcggg aagcggcaag agagccagta tgtgtaccgc
     5941 gtgaagcatt gccagcagtt gtcatggcgt gtacaactgc ttcaatgact tcgtgtggtt
     6001 tatgcagcgt ggtagctgcg ttatcaaaat aaatcataat atcctcattg taaattgtag
     6061 tcaggttgtg attggattct catagatcgt aattcagata gtagtggcag caatcgctgc
     6121 accaattgct ccagcatagc gaccgtcagt atcggttaat acatctgttt ttaaagattc
     6181 tccgagcgat ttcttaagat aagagtaatc acataatcca ccagtgagac agatacattc
     6241 ttcctgtccg tttgtaagtc ttgctgcctg tgatacaact ttttgtacga tagagtcgat
     6301 aacggcaaag gcaatgtttt ctcttgattc tccacgtccg attaaactga ttacctcaga
     6361 ttcagcgaac acagtacaca tggagctgat agaagttccg ctgccttttg aagcaagctc
     6421 acacagatct tgtggggtta gagataatgt atttgccatg acttcaagga atcggcctgt
     6481 tccagcggaa catttatcgt tcatgaggaa gtcagtgacc atatcgtttt caatgcggat
     6541 gattttcgta tcctgtcccc cgatgtcaat gaggagcata ttttcatttt tatgaatata
     6601 gcaggctcct tttgcatggc aggtaatttc tgtgacgcat tttgcagcat aagggacgga
     6661 tacacgtcca tatccggttg cgacaacaac ggatttttct ggaagaattc ccttttccat
     6721 gagcgtttcc tgtatttgct ttgcagtatc tacactactc cagccagttg gctgtaaaaa
     6781 acggtggaga atttcttttt catgattcat gacaactgtt ttcgcacagg tggagccgat
     6841 atcaattcca ataaaatatt tgttcataat aagtatcctg aatatttttt cttttaaatg
     6901 ctaataaatt aaatttctaa aatatgtgta gaagcccact cgattccttc ttttgtgagt
     6961 gcctctatta aaatagtttc atcttctgga gcggctttcc aggcaaagcc acagccggcg
     7021 gtaatttcgc gtggaacagg aattaatcgt ccgggaagac cattttttgc acagagttta
     7081 tcggttgcca ttgcctgtgt agttgcgtca aatgcgatga tgaatgcagg ctttttcttt
     7141 ctaagcatag gtaaactcct ttatttaagg ctgcacgatt aagtcggctt gtgtcatttt
     7201 ttcagcgatc acatacatgt ttgttacttc accgacctga agcttatcag taagtccata
     7261 gaagtttaaa caggttccgc aggtgaggat ttcaacaccc tgggcttcta aagattttaa
     7321 atcttcaata gaggcagatt cttcgcaagt gatatatgca ccgctattat agaaaaggat
     7381 agtagaagga agagtatctt gctggcttaa ggcatagata aatcccttta ataaagcttt
     7441 tccaagttcc tcttcgccgt ttcccatctg atttgagcgg ataactacga ccgtattttt
     7501 tttatttaac ggagtaatcg gacagttctc ttcttctatt gttgccacag cactattcgc
     7561 ggcaatctgt gcagcttctg catttatagt cattgtaact ttaaattcat tatcagcaac
     7621 tttttcagaa tgtacatcgt atcctttctg gtttgccatc tttgtaagat tctgtacggc
     7681 aatttcatta tcaacaagtg tctctactgt ccctccaccc tgtaattcgc ggatggcatt
     7741 cttagttttt actactggga ttgggcaggc atcgcccatt gcatttactt taatcatgat
     7801 tgttcctcca ttttgtatat ttataaagaa tgtaaagaat gtctcggcat tcttgctgca
     7861 agatgtgcgt catgcaatga agccatactt ttactgcaca tctgatatgt tctatgaatc
     7921 attctggtat ttattttgta agaaagattc taagagtagg ttgtgttttt taaaattcta
     7981 aataggtaga agtcatttaa ttcgtgacta aaatttctgg ttctgctttt tccaaaactt
     8041 ctccgacaat ctcagcagga agaccggaag cttttaactt gccaagaaga gcaggtgcat
     8101 cttcttttgc aagagaaatg agcagaccac cggatgtctg agggtcaaaa agaatttctt
     8161 ccattgcaaa tgggatatct tcaaactgga caaatggccc agtaaagtta cggtttcttt
     8221 gtccggcggc ggttaaaaga aattcatcag cgtgccgtaa ggcctcttca aaaacaggaa
     8281 cctgtccggc atgaatatga caggaaagct gtccatccat catttcatga aggtggccta
     8341 gaaaactaaa tcctgtaacg tctgtgcagg catggatttc gaaattcctg caacactctg
     8401 cggcgtactt gttcaaggtt gtcatggagt ctgttacggc tttcatcgct tccacagaag
     8461 cttctcctac tcgatttgct gtgcagatga taccgacacc aagccgcttc gtaagaatca
     8521 gtgcatcgcc cggtttcgcc ccgttattcg tatagatttt attcggattg acgatgccgg
     8581 taacagaaag accatatttc acatccgaat cagcaataga gtgccctccg gcaagtgttc
     8641 cgccggcttc aattactttt tcggcaccgc ctcgcataat ttcacctaaa atgttcaaat
     8701 ccattttttc aggaaaacag acaatattta aggcggtttt tacttcaccg cccattgcgt
     8761 aaatatcact taatgcattt gtagcagcga ttttcccaaa agtgtaaggg tcatcgacca
     8821 tcggaggaaa gaaatcaagg gtttgtacaa aagcaatatc atcagatatc ttatagacag
     8881 cggcatcatc tttactgtca taaccgacaa gaagattctc atcttccggt ccctgcggca
     8941 gcttcgataa tatacgactt aaaataccgg caccaagttt agcggtacat cctcctccct
     9001 tgcaaaatag tttttctttt tccataatag gcagcctcct tttatgtggg atgtactctc
     9061 agtgcttttt atgtatgtgc ttgttaccac tgaaaaatac ttttatgatt cctcttcaat
     9121 gtaatttcag aacttttcat acatttactt ttgtaaccga ttttgcgagt acattttggg
     9181 taaaatttcc caacataatg taatttattc taaaattagt ttaatagata ttgtacagaa
     9241 agtaaagttc attatttcga taatatagat atgattattg ataaaaacga tagatatggt
     9301 aaaatatatt tattctggag tgttttcgac cagagtattt taaacttacc ggaaaggaaa
     9361 gtgagaaaat ggatatacat caattgcaga tttttgcaaa tgttgcagaa tgtaaaggtt
     9421 ttttggcagc atcgaaaaaa atgcatctct cgcaatctac agtcagtaca catgtgtcag
     9481 ccttagagca tgagcttggg aaaaagctga ttcgacgtac agcaagaaat tttgaattga
     9541 cagaagatgg ggtaaaactt tataagtatg cggtagacat tttactttta catcggaaag
     9601 caataatgga agttgggggg aatggaagtg agtttcttcg gattggtaca tcttctgttc
     9661 cggcacagtg gtttgttcct acaatattga gtggattttt aaagaaaaat gtaaatacgc
     9721 aggtggagat gacgagtgcg gatagtttag atattattcg tcgggtaaaa gagggaagtc
     9781 tcgatattgg atttgttgga acgaaagtag aaaaacagtg caagtatatt tctcttgtga
     9841 atgatcatct ggttttggca gccccgaata caaagaaata tcaaaaaatt tttgtaggag
     9901 agagtggttc aggagaaagt gatttaagac agattttaga gtctccgttt ttggcgagaa
     9961 gacaatattc cggaactatg aaagaggcat tggggagttt ggagtatttt ggcataaagg
    10021 aagaggactt aaatatcgtt gccacctttg acagtgcaga gatgttaaga gattgtgtag
    10081 aagcaggaat gggaatttct attctgtcgt atgagatgat aaaagaattg catgaacggg
    10141 ggaaaatatt gatttataga ttgccggaaa aggaattttg cagggaatta tatcttatct
    10201 ataaaaatga atcttttctt ccagaaatag tgaaaaagtt tattcattat acagagaagt
    10261 attttaaaaa agaattttaa ggagatatat gtaacttatt aacggttcaa caaagtcggt
    10321 ataatcaaga atttttgttg aacatgcact aaaaggaata gagagaaaaa atgtaccgaa
    10381 ttttaattgt cgaagatgat tctacgattg ctttgaatat ggcagcacat ctggagcggt
    10441 gggattatga gactaaacaa atagaagatt ttaaatgtgt gatggaagta tttcagcagt
    10501 ttgatccgca gcttgttatt ttagatattg gtttgccgtt ctataacgga ttttactggt
    10561 gtcaggaaat ccggaaaata tcgagtgttc caattctgtt tttatcctct atgaatgata
    10621 atatgaacat agtgatggca atgaatatgg gcggcgatga atttattgag aagccatttg
    10681 atctaaatgt actaacagcc aaggtacagg cattactacg ccgggcctac tcctttcaag
    10741 gaaatgtcaa tgtgttagag catgaaggta tgctccttaa tttaaatgac gcttctcttt
    10801 cttataaggg ggagaaaata tctcttacaa aaaatgaatt tcgtattttg cagatgctta
    10861 tggagaatgc tggaaagatt gttgcaagag atgatattat cgcaaggctg tgggagagtg
    10921 acgaatttat tgatgataat acacttacag taaatgtggc aagacttcgt aaaaagttag
    10981 agaatgcggg tatggaagga agaattaaga cgaaaaaagg aattgggtat tatttggata
    11041 aatagaggaa agaaagagaa atgatcaaag aaagtatttt ttcatttttg aaaatccgca
    11101 aagtgctaat tattatattt ataggaatcg ttgtgatatt tggaatacta ttttatttat
    11161 atgatattcc ttttgatgcg attatctatg gatgcgaatt gtcttttgtg tggtgtgcag
    11221 tatgtctgtt tattgatttt tacaaatatt ataaacggca taagttatta catatcaaca
    11281 gggagcagtt ttttgacgat gcagaacaac tcccagagca tatggatatt attgaatatg
    11341 attatcagga gcttgcaaag aaattatatc aggcaaagca ggagcttatt tctaagaatc
    11401 gaattgcaaa aaaagagctg cttgattatt atggcatgtg ggttcatcag atcaaaacgc
    11461 cgattgctgc attggatatt ttattacaga ataccgaacg gatgttatat cagctcgatg
    11521 agaaagagat gatgcagaag gcaatatctg tttctgatat gaagatggaa cttttcaaga
    11581 ttgaacaata tgtagagatg gcattaaatt atcttcgggt agaagatata tcttctgatt
    11641 tagtgtttaa aaagcatgaa ctagatgata tggtgcgtca ggttatccga aaatacgcaa
    11701 agattttcat atctaaaaag ataaaaatag attttaaact gacaaaagcc tgtatagtaa
    11761 cagatgaaaa atggtttatt tttgtactcg agcaaatcat atcgaatgcc ttgaaatata
    11821 taaagaaggg acagattttt atttatatga aaaaaaaatc tcttgtgatc gaagatacag
    11881 gaatcggaat tccggcagaa gatcttccgc gaatttttga aaaaggcttt actggatata
    11941 atggcagaga gaacaagaag tctaccggaa tcggtctgta tttatgtaaa aatattatgg
    12001 ataaattgca gtggaatatt acagtagatt cagaggtggg aagcggaaca aagatatatc
    12061 ttacaaaaat gtaaggtaag aacagaaagt gttaggtact tcgatggaag tagctgcact
    12121 ttctttttat aataaacctg taagcttagt tagagaagag aaaggcaggg aattataatg
    12181 gcattattag atgtaaaaaa tgttcgtaaa gtatatacaa cacgttttgg cggaaatcag
    12241 gtggaagcat taaaagatgt aaacttttct gtggagcagg gcgaatatgt agcaattatg
    12301 ggggaatctg gttcaggaaa aagtacactt cttaatattt tagcggcact cgataagccg
    12361 acggaaggaa aggtattttt aaaagaaaaa gatttaagta aagtaaaaga aaaagagatg
    12421 gcggcatttc gccggaataa tctgggattt gtatttcagg actttaatct tttagatact
    12481 ttttctttaa aggataatat ttttcttcct cttgtacttt ccggaacatc tcataaagaa
    12541 atggaaagaa gacttcttcc acttgcagat aaacttggta tcaaaaactt gctggagaag
    12601 tatccctatg aagtttcggg aggacaaaag caaagagctg ccgttgcaag agcagttatc
    12661 acacagccac agcttctgct ggcggacgaa ccgacgggag ctctggattc taaggcagca
    12721 aaagaactgc taaagctatt taccagtttg aatcaagacg gacagaccat cctgatggta
    12781 acacatagtg taaaggcagc aagcacagca gggcgggttt tatttattaa agacggccgg
    12841 gtatttcatc agatttacaa aggaaacctc agcgagacac agatgtatca gaagatttcc
    12901 gatgcgatga ctgcaatcac agcgggaggt gcggatgatg aatagtaaaa tttatggaaa
    12961 gcttgcagta acaaatttaa aaaataataa gaaaagttat attccatata ttttggcatc
    13021 tgcattttct gtaatgatgt attttactat ggataatctg taccgaaatc gttctctagt
    13081 agaaaaaggt agcccgcttg cgattatgtt gtcttatgca gcagcggtaa ttctcatttt
    13141 ttcgattatc tttttgtttt atatcaatag ttttttaatt aaacgccgga aaaaggaact
    13201 gggaatatat aatattctgg gaatgggaaa aggacatctt ggcaaaatgc tttttcttga
    13261 atctgtaata acaacggcgg caagtatcat tggtggtatt ttagcaggca ttcttttggg
    13321 caaactcgtg tatcttatat tattgaaaat actgcatatg ggtggaaaga tagagtatag
    13381 aatctcactg gcatctattg gaatgacaac gatttttttt ggcgcaattt ttattttgat
    13441 ctttctgtat aaccttttac agatgaagct ttcaaatcca atcgaactgc tgcgtggagg
    13501 aaatacggga gaacgagagc caaagacaaa atggatcatg acgataatcg gaatcctctg
    13561 tttagcagga ggttattcta tcgcacttat aacaaaagaa ccgatggcag cattaggaaa
    13621 gttcttcatt gcagttatac ttgttattat agggacgtat gctctgttta tggcaggaag
    13681 tattgcattt ttaaaaatgc tccgaaacaa aaaaagctat tattataaga cgagacattt
    13741 tacagccgta tcaggcatga tctaccgaat gaaacagaat gcggtaggtc ttgcaaacat
    13801 ctgtatatta agcacaatgg ttcttgtgat ggtttctatg acagtatcct tatatggggg
    13861 attgaatgat gtgattgtga cccgttttcc atatgaggcg caaatcacaa gttcaggaat
    13921 caatcaaaaa gaagaaggac agatagaaga aattataaag aatatgacaa agaaaaatca
    13981 cacaatgcca acttcacaga tacgttttca tgtagggcga tttacaacag tatataataa
    14041 caaaacgaag aagcttgata tgatggcagc gggggattat accaattcaa atactgtaga
    14101 tttagttatg attccacttt ctgattacaa tcaaacagaa gggaaaaatg taaaactgaa
    14161 agaaaatgaa gttcttcttt atcatagaaa tcataaaaga acccataaaa aaagtgatac
    14221 agaagcccta aaaaataaga aagtcattca gttaaata
//
