LOCUS       gnlProkkaCGLPFGGI_15   16897 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGLPFGGI_15.
ACCESSION   gnlProkkaCGLPFGGI_15
VERSION     gnlProkkaCGLPFGGI_15
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 06:43:14
            Original ID  :: gnl|Prokka|CGLPFGGI_15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 36987
            Orig. end    :: 53884
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16897
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12631]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12631
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..16897
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16897
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             60..266
                     /locus_tag="ctg15_27"
                     /transl_table=11
                     /translation="MDKEKEIKAYLDGELLPEVRMKYEIAEEMGLLDRVLSDGWKSLSA
                     KETGRIGGLMTKRKKRETEKINE"
     CDS             381..1349
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 217.2; E-value: 6.4e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_28"
                     /transl_table=11
                     /translation="MKLGILGAGGIASTMAKTVAGMKDVEAYAVAARDLERARVFAQKY
                     EVKKAYGSYEEMLADDEVELVYIATPHSHHYLHAKMCLEAGKHVLCEKAFTVNAEQAQK
                     LFDLAKEKKLLITEAIWTRYMPSRKLINDIIESGVIGEVTAVTANLSYTVSHVERIRKP
                     ELAGGALLDVGVYPINFASMVLGDKVKDVKATAIFQNGVDILDSIAMVFEGDRMATLQC
                     GAREISDRMGSIFGTRGYMQVQNINNPEKITVFDTEHKEVASYVVPEQISGYEYEVESC
                     MKAIHEGKTECPEMPHAETIRIMKIMDDIRKSWNYEIPCIE"
     CDS             1538..4219
                     /locus_tag="ctg15_29"
                     /transl_table=11
                     /translation="MKSNYKIFTAVFLSAIMTAAAPLTVCGAEVFSAGESFSDGTGSIP
                     AILTDMVLPDGEIGTEYQVQLEADTDVNWSLEEGSELPAGLTLSSGGVISGTPQKEGSF
                     SFTVQADNGIGVSSQELSLYVAQREQEPVIKQYELTSGTALIDLGIHAEGEQSRKRLFL
                     YNAGTDSLHLSDFPQSRYFDFSYAPIFDTNTDEEMQPGSCAAVDIDDKKDLPAGNYEET
                     VTFETKEGASCKVTLKVIVGASSEKDYELSIETGTEEEFTESDFYDPEFRVEKYVVVRN
                     SGKKETRIRIDTSDLKNFEVDDQMAKWTEDYEEQDSKKLLKPGETLYFYILPKQEYGIY
                     DETFAFLADDGSRYPLHVTMNREKNPTEKKQLEITEKSAGGFPTMQWGYKTLPEAKTYI
                     LKNVTDTDMKLSFNRSKECSVLLSGNAYLAPGESTELRLWPKLGLSVGKYSFQVTVTAK
                     TVAGEHLTTQNLYNSFIVGDWTYQGLADAVAPVTGITNGAEKTVDALHLPNSLEVYGAE
                     VNGEKTTFSASVKWDVENCAYDPKSKAAQSFLVNGSLELNEDENNEGLDTAVQIMVQVD
                     AYQTLNRPVIDTRWTRVITNYAMLYLRDLSNEADGYQFVTAKSQKDLKKGNYTAQTKIT
                     NSELNQYPELKYIPEGTHSLYCRAYKENSSHVMEYGEWSDGVPVTVKAKTPDAPVVQKV
                     QVKKNDVRIVLNSKGEEPDGYDVVAARSKNGKEPSDYIKVKSGYSGSSKELILRGVPAG
                     TWYIGVHAYKYLNGSNTKVLSKWAEVRKVTVKTSLVTGKPAVKSAKVSRQGTKRNVTVT
                     FTVPKSCDGTDWVLAKKVSKSDDGSYTGVSSYAYTKKNQTKTTAVFKSVKPGVYYLAGR
                     AYVKGYAKSYTKWSKIKKIVVK"
     CDS             complement(4899..5318)
                     /locus_tag="ctg15_30"
                     /transl_table=11
                     /translation="MHGLIQEMIHFRNETLLSCNLDPEKISGFEERYLKILETTRKEYE
                     DIPANAYYKDGYNLFLRMEKYMQNHLLFLHDFRVPATNNEAERLLRNYKRKQAQAVTFR
                     SFESIENLCQCMSMLVLMRLEDPANIYDRVSRIFG"
     CDS             complement(5537..6436)
                     /locus_tag="ctg15_31"
                     /transl_table=11
                     /translation="MTKTEKAVTWAIAIADDHTHGYDQVHRWGPDYDCSSLIISAWQQA
                     GIPVRTNGASYTGNMKSVFLACGFTDVTSRIDLLTGNGMKRGDVIINTMHHTVMYIGNG
                     QIVGARINENGSISGGKTGDQTGKEIMVQNYYVYQHGWDCVLRYAENNSDVDFSTETIS
                     SSRYENISKGQMYAARFLCAKNFSTLLANSDIRKIKIKVLQTALNKDYQSALDIDGIWG
                     PATDRALNQHCVMSGETQYMVTAAEILLLLHGYNPKSIEFPGIFGSGMLAAVKTFQKAH
                     GLAISGICDRETFLKLIS"
     CDS             complement(6649..6984)
                     /locus_tag="ctg15_32"
                     /transl_table=11
                     /translation="MKKNTIGKRIAEARINLNITQEQLEELSGFSVSTISRFETGRTQP
                     SIENLIKLSKVLNVGIDYFLYDLIPHNETIQSPTVKDAVTVLSQMNERQAQYMLDIIKI
                     YQASHQD"
     CDS             7101..7688
                     /locus_tag="ctg15_33"
                     /transl_table=11
                     /translation="MTDADRTDKAEERENMYIMMFTLQSLQNYGLSVKKTVERSLDYLW
                     EWYQESGEERYLLLAKQHMQAYVNMGFALNEQNQTICDIISILDQTIADFYPKDSLPGK
                     RVKLTKAQIRSMIGRWRPSRENPMTIGELVEDIIKKVKEHQTGRYIYRYCRSDCTSGED
                     AEIYELVVGREESYFYDVRKFRFYTFMEKTKK"
     CDS             7685..8395
                     /locus_tag="ctg15_34"
                     /transl_table=11
                     /translation="MIRIAILDDEKADLEKEEQITRQYFYNRQAESEIATYQSVEWFLL
                     GLTEEKFDLYILDAEMPVKNGIEVAKEIRKLYPEPVIIYVTNHLNYAVEAYEVNTYRYI
                     AKDTMEKGLNAAYETLLPILLAKEERYYIVKKRSELEKIAYSDIFYVKKEGKCAVIVHR
                     NGETSVRDSLSAVEKALGSREFIVADRGYLANIRHVMKMKSRELYMRNGNIITVGRERF
                     KHVRKAILDYWKEI"
     CDS             8399..9862
                     /locus_tag="ctg15_35"
                     /transl_table=11
                     /translation="MWMVLLYGLATFMETGVGVWMFGRMFPERKSSSEYRWAKMILLTL
                     LILTTYTMHRAYGQEYIYEKFFFIVVYAGVMISDAILYKYRDFFRINKKTEKIILFSYI
                     SIMLTWQYWVSYVSFGIIAIANLYLPFFLLLFYKCDFVQAYLWEVLYLVNIGLAKILYI
                     YIIGMIKHRRIENFLFSKSVHFYAGVVYLLIIYVLFLIIQKNFCVEKWLKDLLTDCKKM
                     ILFVALSECSILYFLLTMNWGYIENRELIISFGVISGIALILLFVFARFLAKSIYTEKN
                     ILEVRNNVIASQYEKLNESYKKYRCLIHDERHMMDYIEECIGTGNLSEAQKIIKKSRNK
                     FSERYYWTGITVLDNVISIEKRKMDNMNIEFHIETDVTDIVMEDIDIIILLENLFDNAI
                     EAVEKCANKKEIKFSIKNINSMLVLKLWNSSCKKPKVKKERFVTDKHDSKGHGWGLESV
                     KYIVKKYDGIIEFEYTEMFFQTVIMIEGE"
     CDS             9865..10008
                     /locus_tag="ctg15_36"
                     /transl_table=11
                     /translation="MDENIKYELAEAEKLEVIDNAGVAENEKKSIVTVLLSLSCCGHIM
                     NA"
     CDS             10001..12631
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     840.9; E-value: 2.3e-254)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_37"
                     /sec_met_domain="DUF4135 (E-value: 2.8e-95, bitscore:
                     311.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.9e-58, bitscore:
                     188.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENICIRILILDISEKKSNHELYGFTVHEEYNFYIKHFWKNESY
                     KCDLAIRYAEGSRLQKLKEKYFVILQNEINEKINIDKDMISKKFHENMNEFQMLNKDQG
                     DIHKNGRSVSKIEFDNGSILYYKPHSLDKDIKYQQLYKYLCEKAGISCREVRCLSRQTY
                     GWEENIENKSCNTKEEIERYYFRLGIHLFLGYALGATDLHGENIVAYGEHPVIIDMETY
                     PGYITKNSGSSTEEKAEIKIREKIMTSVLNTGILPVLTWGTGNNRVLMSAVNMHGKIRT
                     PFKMPVVKDDKTSNIHIEYEQVEFEIKECIVRLNGEVVNSEEYTGEIIRGFRMAYTEIL
                     QNQKLRNMLKTFFQGKSRVILRHTQQYYMYLFASFHPDYMKDRKQREELLQVLHKKGET
                     QLQKELRDYEIQSLLELDIPYFEIDGNSRSIFDGNGKEYQGYLPCTPYESWIEHMKQLS
                     RQDMEQQCEYIRLSMGLLNHGYIGEKNPRWADENSCIHQIAEWICRTAVIEEDDIGWAG
                     LHFWDNGYWSLKPCGMYLYDGIAGIVLFLAKYLDQYQDSSCRKDVEKIYKLAIEKLEKY
                     TDLRCEQNEVPEPLATGLYDGESSIVYVYLILYEITGQEKWIKNAQKHFEIVAKLLPKD
                     ENMDYLSGNAGAIVAALKLYQLTGEIEYCTAAIETEKDLWKKGQRMEVGYGWKLKNLKY
                     PLSGLSHGNSGFLMTYVELYKMTYDQEYLKKIKLLLSYEDILYSEDLKNWIDLRDSDGR
                     KTMCGWCHGAPGILLSRMSIMDILPDDKQIKKDILRAVSTLFHNEREKKICLCHGMTGN
                     LLIMKKYLEKNPDDDLRQKYERQFSNLKEQLQDMRSLMVTETLNPAFMNGITGVGMAMM
                     LLNMD"
     CDS             complement(12652..13182)
                     /locus_tag="ctg15_38"
                     /transl_table=11
                     /translation="MKSLLQLIHDYHSGVKNADEEILKRMEPLIKSYASRIHCMERDDA
                     TQELYLTLLNTLPYLNGKNFSEGECVRYMQTAIENRYRALCRYHLSEPERENFDTCSLT
                     LQADNPFDETLYDITTYIESFPVQSMEYKILSLFFYQYKTDSEIASILHVSRQYINRQK
                     KKLLKTYFFRHPD"
     CDS             13401..13631
                     /locus_tag="ctg15_39"
                     /transl_table=11
                     /translation="MESTVMETAISQGIWAVLAVFLLIYIVKSNEQRDAKQEEREKNYQ
                     TVIENLTEKFQILNQVQNDLKEIKDNLLNKN"
     CDS             complement(13713..13784)
                     /gene="allorf_50700_50771"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_50700_50771"
                     /protein_id="allorf_50700_50771"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNICNYRIKRILMDMSVFACISD"
     CDS_motif       complement(13728..13784)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNICNYRIKRILMDMSVFA"
                     /locus_tag="allorf_50700_50771_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13713..13727)
                     /prepeptide="core"
                     /locus_tag="allorf_50700_50771_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.30"
                     /molecular_weight="418.5"
                     /monoisotopic_mass="418.2"
                     /core_sequence="CISD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNICNYRIKRILMDMSVFA"
                     /leader_location="[13727:13784](-)"
     CDS             13837..15951
                     /locus_tag="ctg15_40"
                     /transl_table=11
                     /translation="MKEYKVITALFLSAVMLGTAPLTVWGAESFSTGESFSDGTENIPD
                     IVTDSALSGESSERDYELSIETGTDVELTESDFYDPEFRVEKYVKVRNSGKKETRVRVD
                     ASGLKNFEVDDQMAKWSEDYEEQDSKRLLKPGETLDFFVLPKQEYGTYDETFDFLADDG
                     SRYPVHITMNREKNPTEKKSLEITEKSSESFPIMHWGYKTLPEARIYVLKNFTDMDMEL
                     SFDYSKDCSVSLSGNTSLAPGESTELSLCPQMGLPVGEHDLGVTVTAKTATGETITKKI
                     WDSFRVDSRTFQGLVDTIEPVTGITNGVEKTADALHLPSVLKVYGAEADGEKTTFSADV
                     KWDVENCAYNPKNTAPQSFTVNGQLELREGENNEELDTSVKIKVQVDAYKALNRPVIDP
                     TWTRVITNYAELSLRDTSNEADGYFFVAAESQKDLEKGNYIAQVKVAKSELNHYPKLKY
                     IPEGTHYLYCRAYKEESGHTEKYGEWSEGFLLKVNIKTPNAPVVQKLQVKKNDVKIILG
                     SNTEELDGYDVVAARSKDGDEPSDYIKVQCRYSGNSKELILKGVPKGNWYIGVHGYKYL
                     DGSNKKVLSKWAEVQKVTVKTSLVTGKPAVKSAKVSRQGTKRKVTVKFTVPKSCDGTDW
                     VLAKKVSQSEDGSYTYVSGYAYTKKNQTKTTVIFKNVKPGVYYLTGRAYVKGYAKNYTK
                     WSEVKKVVVK"
     CDS             complement(16138..16896)
                     /locus_tag="ctg15_41"
                     /transl_table=11
                     /translation="MYNSYKYLVKYQQYSALGYCSDYMNTAAKPIPVIAHTNGLLGHAN
                     GMSCFDNRFYVVAGDNKVVALNCNSGKEEAVYTITPASLRLKAINYFYETNTALLLSIE
                     NGKMLLYKCTFGDTKKPSAVYLGTIENPGQPVSQDIFYHNKYGLFVGTCNANLAAQNVV
                     TTKNTLLHYDLKKLSTKTSLYPDFGFVTNMPAKNAEGQVYNSFELESVALDTNTKKLAA
                     VCNVNVKKSNSDTTLVSMDGFFQYNTIEFI"
ORIGIN
        1 ataaagtata aaaattaaga aaacagccca tactccaaag aaaaggagtg tgggctgttt
       61 tggataaaga gaaggaaata aaagcttatc ttgatggaga attattgccg gaggtcagaa
      121 tgaaatatga aattgcagag gaaatgggac tgctggacag agtattgagt gatggatgga
      181 aaagtctgtc tgcgaaagag accggaagga ttggagggtt gatgacgaaa cgaaaaaaaa
      241 gagaaactga aaaaataaat gaatgatatg ggataaacat ataacggaat aaacttgttc
      301 tccgggcgat gatgctgtaa aattagagca agtagcgaag tggataattt tatctgctat
      361 aaatatggga ggacaataaa atgaagttag gtattctggg agcaggaggc attgcttcta
      421 ctatggcgaa aacagtggca ggaatgaaag atgtggaggc gtatgcggtt gctgcccgtg
      481 atctggaacg tgcccgggta tttgcacaga aatatgaagt aaaaaaagca tatggatcct
      541 atgaggaaat gctggctgat gatgaggttg aactggttta tatcgcaact cctcattcac
      601 accattatct gcatgcaaag atgtgtctgg aagcgggaaa gcatgtgctt tgtgaaaagg
      661 catttactgt aaatgcagag caggcacaaa aattatttga ccttgcaaaa gagaaaaagc
      721 ttctgatcac agaagcaatc tggacaagat atatgccatc cagaaagttg atcaacgata
      781 ttattgaaag tggtgtgatc ggagaagtta cggcagttac cgcgaatctc agctatacag
      841 taagtcatgt ggaacgtatt cgtaaaccgg agcttgcagg aggtgctctt ctggatgtag
      901 gcgtatatcc aatcaatttt gcctccatgg tgcttggcga taaggtaaag gatgtaaagg
      961 ctactgcaat ctttcagaat ggagtggata ttctggatag cattgccatg gtgtttgagg
     1021 gagaccgcat ggcaaccctt cagtgtggag caagggaaat ctcagacaga atgggaagta
     1081 ttttcggaac cagaggatat atgcaggtgc agaatatcaa taatccggaa aagattacag
     1141 tgtttgatac cgaacataaa gaagtggctt cttatgttgt gccggaacag atctcaggat
     1201 atgaatatga ggtagaatcc tgcatgaaag caattcatga gggaaaaacg gagtgtccgg
     1261 aaatgcctca tgcggaaaca ataaggatca tgaaaatcat ggacgacatc cgtaaatcct
     1321 ggaattatga gattccctgt atcgaataaa aagtgtggaa taatcttatg aaaaagacca
     1381 gtaatgtttt tgacatatac ccgaaacatt actggctttt ctgatattca tgaccattag
     1441 actacatatc attccgtaat tacagaaaca tttccgtcca gtggtatatt aattaggtaa
     1501 attgatactt ttatatttta ttatctggag gagaagaatg aaaagtaatt acaaaatttt
     1561 tacagcagtt tttttatcgg caattatgac agcagcagct ccgttaacag tatgtggggc
     1621 ggaagttttt tcggcgggag aatctttcag tgatggaacg gggagtattc ctgccatatt
     1681 gacagatatg gttctgccgg atggagagat tggaacggaa tatcaggtac agcttgaagc
     1741 tgatacagat gtgaactgga gtctggaaga gggaagtgag cttccggcgg gacttacgtt
     1801 gtcttccggg ggagtgatca gcggaacacc gcagaaggaa gggagtttca gctttactgt
     1861 acaggcggac aatggtattg gagtttcttc acaggaactg agcctttatg ttgcacagcg
     1921 tgagcaggaa cctgttataa agcagtatga gctgacatca ggtactgctt tgatcgatct
     1981 gggaattcat gcagagggag aacagtcacg taagcggtta tttctttata atgcaggaac
     2041 agattcgctt catctctctg attttccgca gagcagatat tttgattttt cctacgcacc
     2101 gattttcgat acaaatacgg atgaagaaat gcagcccgga agttgtgcgg ctgtggacat
     2161 tgatgataag aaggatctgc ctgccggaaa ttatgaagag acagtgacat ttgagacaaa
     2221 agagggtgct tcctgtaagg ttactctgaa agtaattgtg ggagcttcct ctgaaaaaga
     2281 ttatgagctg agtatagaaa caggtacaga agaagaattt acagaaagcg atttctatga
     2341 cccggaattt cgtgtggaga agtatgtagt ggtcagaaat tcaggaaaaa aggaaaccag
     2401 aatacggata gatacttccg atcttaagaa ctttgaagtg gatgaccaga tggcaaagtg
     2461 gacagaagat tatgaggaac aggattccaa aaagctgctg aaaccgggag aaacgcttta
     2521 tttttatata ttgccgaagc aggaatacgg aatttatgat gaaacgtttg catttctcgc
     2581 agatgacgga agcagatatc ctcttcatgt tacaatgaac agagagaaga atccgacaga
     2641 aaagaagcag ctggaaatta ctgaaaagtc tgccgggggt tttccgacaa tgcagtgggg
     2701 ctataagaca cttccggaag caaagacata tattctgaaa aatgttactg atacagatat
     2761 gaagctgtct tttaaccgta gtaaagaatg tagtgtgtta ttatctggaa atgcttatct
     2821 ggcacctggg gagagcacag aactgagact ctggcccaaa ctggggcttt cggtgggaaa
     2881 atatagtttt caggtgactg tgactgcgaa aacagtggca ggagaacacc tgacaacgca
     2941 gaatctgtat aattctttta ttgtaggaga ctggacttat cagggactgg cagatgctgt
     3001 tgcgcctgtg accggaatta ccaatggtgc agaaaaaact gttgatgctt tgcatctgcc
     3061 gaattcgctg gaagtctatg gcgccgaggt gaatggagag aaaacaacat tttctgcgtc
     3121 tgtgaagtgg gatgtggaga attgtgctta tgatccgaaa agcaaggcag ctcaaagttt
     3181 tctggtcaac ggatctctgg aactgaatga ggatgaaaat aatgaagggc tggacactgc
     3241 cgtacagata atggtacagg tggatgctta tcagacatta aacagaccag ttattgatac
     3301 gcggtggacc agagtgatca caaattatgc aatgctttat ctgagagatc tttccaatga
     3361 agcagacggc tatcagtttg tgacagccaa atctcagaag gatctgaaaa aggggaatta
     3421 tactgcgcag acaaaaatta caaattctga actgaatcaa tatcctgagc tgaagtatat
     3481 tccggaggga acacatagcc tttattgcag ggcatacaaa gagaacagca gccatgttat
     3541 ggaatatggg gaatggtcag acggggttcc ggttacggta aaggcaaaga ctccggacgc
     3601 acctgtggtt cagaaggtgc aggtgaagaa aaatgatgtc agaatagtac ttaacagcaa
     3661 gggtgaggaa ccggacggtt acgatgttgt tgctgccaga agtaagaacg gaaaagaacc
     3721 atcggattat ataaaggtaa agagtgggta ttccggaagc agtaaagagc ttatcttacg
     3781 gggcgtaccg gcaggaacgt ggtatattgg cgtacatgct tataaatatc tgaatgggag
     3841 caataccaaa gtgctcagta aatgggcaga ggtcaggaag gtaactgtaa aaacaagcct
     3901 tgtaacagga aaacctgctg ttaaatcagc taaggtttcc agacagggaa caaaaagaaa
     3961 tgtaacggtg acgtttactg ttccaaagtc ctgtgatgga acagactggg tactggcaaa
     4021 gaaagtttcc aaatctgatg acggcagcta tacaggtgta agcagttatg cttatacaaa
     4081 gaaaaatcag acaaaaacca cggcggtctt taaaagtgtg aagcccggag tctactacct
     4141 tgcaggacgt gcctatgtaa aaggctatgc aaaaagttat acgaaatggt cgaaaataaa
     4201 gaaaatagtt gtgaaataag cactgttgtc aattgtttca cagagatttc acttttaaga
     4261 agaaaaatcc cccttttacc aggcgtttat acctgctttt tcccgtaata ctcaaagttt
     4321 acggtactgc caataaactt attatactca aatcttgtct gaatttggag atatcattta
     4381 tatcaggcaa aaggtgccct gacagaaatg aaagaaagtt tcataggtga aaataaagat
     4441 tcgaggtcag atgatgtatg tttagaccca cttttatatt ttcggcatca gcttaatgta
     4501 aaataatagt gggtaaagag gatataagat gttctggtac acgaaataag aagaaaggag
     4561 atatgccata tggtcaaaat gatgaactgc ctgagatgat caggcggttt tggaatatct
     4621 ggatttttta tgaatatttt atttttacac cactttacaa ctttttttat ataaaataat
     4681 cgtacagggc tttctgatgt ataatgaatt tgcacaatca ttacgaaaga aagtgaccct
     4741 gtacgataaa ttcattatac aacgaaaata cattaattgg tagacttcgt aaatattttt
     4801 cagcatattt tgaaactttt tcgttactgt tcaaaggtta gctggactta gaagaaccga
     4861 tggtgtagac tgataacagt caaagccatc ggttctcttt atccaaatat cctggacact
     4921 ctgtcatata tatttgctgg atcttcaagg cgcatcaaaa caagcatgct catgcattgg
     4981 cagagattct cgatgctttc gaaactcctg aatgtcacgg cctgcgcctg tttccgctta
     5041 taattcctta gaagcctttc tgcttcatta ttcgtggcag gcaccctgaa atcgtgcagg
     5101 aacagcaaat ggttctgcat atatttttcc attctcagga acaggttata cccgtctttg
     5161 taataagcat ttgccggaat gtcctcatat tctttccggg tcgtttcgag tatcttcaga
     5221 taccgttctt caaatccgga gatcttttcc gggtctaagt tacaagacag cagggtctca
     5281 ttccggaagt ggatcatttc ctgtatcaga ccatgcattt ctttattcca tgcacgggcc
     5341 ggttcattat ccatgctgtc tttgagatac cgtagtacat gggcaagaca ttcctgatag
     5401 aaacgtttct tttcgataaa tttgttattc tccagagtac cgattatgta aaagaagacg
     5461 ttatttttcc aacatcgaca acaaagaaat cttcgttatt ttcagtaccg taataggaaa
     5521 taaagagtag aaaaaatcaa ctgataagtt tcagaaaagt ttctctgtca cagattccgg
     5581 aaatagctaa gccatgtgct ttctggaatg tttttactgc tgcaagcata ccagaaccaa
     5641 aaatcccggg aaattcgata ctttttggat tatatccatg caggagaaga aggatttcgg
     5701 cggcagttac catatattga gtttcgccgg acataacaca atgctggtta agggcacgat
     5761 cagtagcagg tccccagata ccatctatat ccagagctga ctgatagtct ttgtttaatg
     5821 cagtctggag aactttgatt ttaatttttc tgatgtcaga gtttgccagc aatgttgaaa
     5881 aattttttgc acagagaaat ctggcagcat acatctgccc cttgctgata ttttcatatc
     5941 tggaagatga aatagtttca gtggaaaaat caacatctga gttattttct gcatatctga
     6001 gaacacagtc ccatccatgt tgataaacgt aataattctg aaccatgatt tcctttcctg
     6061 tctgatctcc ggtttttcca ccggaaatgc ttccattttc attaatacga gcaccaacga
     6121 tttgcccatt tccgatgtac ataacagtat gatgcatggt attgataatt acatctccac
     6181 gtttcattcc atttcctgtg aggaggtcaa ttcgggatgt aacatctgta aaaccacatg
     6241 ccagaaatac agacttcata tttccggtat aagatgctcc atttgttctg actggaattc
     6301 ctgcctgctg ccaggcagaa ataataagag aggaacagtc ataatcgggt ccccacctgt
     6361 gaacctgatc atatccgtga gtatgatcgt cagctattgc aattgcccat gttactgctt
     6421 tttctgtttt tgtcatatta ttatctcctt ttgattgaat gttataaaac tcctgatctg
     6481 gatatgagaa atgtcaaaaa tgtggttggg aatgccataa tagaaagagt agaaaaataa
     6541 aaaaatagaa acaaaaaaag cacttttgaa ggctgattta aacctttcgg ggacaaaaaa
     6601 gtgctttttg aggacaaaaa ctgtataaaa agaaaaaaga ggataaaatc aatcctgatg
     6661 tgaagcctga taaatcttta taatatcaag catatactga gcctgtcttt cattcatctg
     6721 cgaaagaaca gtaacggcat ctttgactgt gggactctga attgtttcat tatgaggaat
     6781 aaggtcataa aggaaatagt cgattcctac atttagaact tttgagagtt ttatcagatt
     6841 ttcaatgctg ggttgcgtcc ttcctgtttc gaagcgactg atcgtgctga cggaaaatcc
     6901 acttaattct tcaagttgtt cctgtgtgat attcagattt attctggctt ctgcaattcg
     6961 ttttccaatc gtgtttttct tcattggtaa aaaattcctt tctttatctg agtttaacag
     7021 attggaagaa agatgtataa ggacataaat gacgtgcgac tggtaaaatc tgatgtgtta
     7081 gaggaggaga aaagtaaaat atgacagatg cagacagaac ggacaaagcg gaagaaagag
     7141 aaaatatgta tattatgatg tttacactcc aatcattgca aaattatggg ctttctgtaa
     7201 aaaaaactgt agagagaagt ctggattatt tgtgggaatg gtatcaggag tccggggaag
     7261 aaaggtatct tctgttggca aagcagcata tgcaggcgta tgtaaatatg ggatttgcac
     7321 ttaatgaaca aaatcagaca atatgtgata taataagtat actggatcag accatagctg
     7381 atttctaccc taaagattct ttacccggaa agagagtgaa actgactaaa gcgcagattc
     7441 gcagcatgat tgggagatgg aggccatcca gggagaatcc tatgacaata ggagaactgg
     7501 tggaggatat tattaaaaaa gtaaaagagc accagacggg aaggtatatt taccgatatt
     7561 gcagaagcga ctgcacttca ggagaagatg cggaaattta tgaactggta gtaggcaggg
     7621 aagaaagtta tttttatgat gtaaggaaat tcagatttta tacgttcatg gagaaaacaa
     7681 agaaatgata cgaattgcaa tactggatga tgagaaagca gatctggaaa aagaagaaca
     7741 gattacaaga cagtattttt ataacagaca ggcagaatct gagattgcaa catatcagag
     7801 cgtggaatgg tttctgctgg gcctcaccga agaaaagttt gatctctata ttctggatgc
     7861 agagatgccg gtaaaaaatg gaattgaagt ggcaaaggaa atccggaaat tatatccgga
     7921 accggtgatt atttatgtta cgaatcatct gaattatgcg gtggaggcgt atgaggtcaa
     7981 tacttatcgt tatattgcaa aagatacaat ggagaaggga ctgaacgctg cttatgaaac
     8041 attgcttccg attttgctgg cgaaagagga aagatactat attgtaaaga aaagaagtga
     8101 actggagaaa atagcatatt ccgatatctt ctatgtaaaa aaagagggaa aatgtgcggt
     8161 gattgttcac agaaacggag aaacgtctgt cagagacagt ctgtcagcgg tagaaaaggc
     8221 attgggttcc agagaattta tcgtggcgga cagaggctat cttgcaaaca tcagacatgt
     8281 gatgaaaatg aagagcagag agctttatat gcgaaacggt aatattatta cggtaggaag
     8341 ggagagattt aagcatgtca ggaaggctat tttagactac tggaaggaga tttaaaatat
     8401 gtggatggta ttattatatg ggttggcaac gtttatggaa actggggttg gggtgtggat
     8461 gtttggtagg atgtttccag aacggaaatc cagttcagaa tacagatggg caaaaatgat
     8521 acttttaacg ctcttgattt tgacaacata tactatgcat agagcatatg gacaagaata
     8581 tatatatgaa aaattttttt ttatagttgt ttatgctgga gtcatgatat cagatgctat
     8641 cttatataaa tatagagatt ttttcagaat caataagaag accgaaaaaa taattctgtt
     8701 ttcatatata tcaataatgt tgacgtggca gtattgggtg tcttatgttt cttttggtat
     8761 tatagcaata gctaatttgt atcttccatt tttcttgctt ttattttata agtgcgattt
     8821 cgttcaagca tatttatggg aagttttata tttagtcaat attggacttg caaaaatttt
     8881 gtatatttac attataggaa tgattaaaca tagaagaatt gagaattttc tttttagtaa
     8941 atctgtacat ttttatgctg gtgttgtgta tcttttaata atctatgtac tttttttgat
     9001 tatacaaaaa aatttttgcg tggagaaatg gttaaaggat ttactgacag actgtaaaaa
     9061 aatgatttta tttgtagctt taagcgaatg tagtattttg tattttttat taacaatgaa
     9121 ctggggatac atagaaaaca gagaattgat aattagtttt ggagttatat cgggaattgc
     9181 attaatatta ttatttgttt ttgcacgttt tttggctaag agcatatata cagagaaaaa
     9241 tattctggaa gttaggaata atgttatagc aagtcagtat gagaaattaa acgaaagtta
     9301 taaaaaatac agatgtctga tacatgacga gagacatatg atggattata tagaagaatg
     9361 tatagggacg ggaaatctct cagaagcgca gaaaatcata aaaaaaagca gaaataaatt
     9421 cagtgagagg tattactgga cgggcataac agtattggat aatgttattt caatagaaaa
     9481 aagaaaaatg gataatatga atatagaatt tcatatagaa acagatgtaa cagatatcgt
     9541 tatggaagat attgatatta ttattttgct tgaaaattta tttgacaatg cgatagaggc
     9601 ggttgaaaaa tgtgcaaata agaaagagat taaattcagc ataaaaaata taaatagtat
     9661 gcttgtatta aagctatgga acagtagctg taaaaagccg aaagtgaaaa aagaaagatt
     9721 tgtgactgat aaacatgatt ctaaaggtca tgggtgggga ttggaaagtg taaagtatat
     9781 agtaaaaaag tatgatggaa ttattgagtt tgaatataca gaaatgtttt ttcaaacggt
     9841 tattatgatt gaaggagaat aaaaatggac gaaaatataa agtatgaatt agcagaagca
     9901 gagaaattag aagtaataga taatgcaggg gttgctgaaa atgaaaaaaa atcaattgta
     9961 acggtattgc ttagtctgtc atgttgtgga catataatga atgcttgaaa atatttgtat
    10021 tagaatattg attttggata tttctgaaaa gaaaagcaac catgagttgt atggctttac
    10081 agtgcacgaa gaatataact tttatataaa acatttctgg aaaaatgagt cttataaatg
    10141 tgatttggca atacgctatg cggaaggaag tcgacttcag aaattaaagg aaaaatattt
    10201 tgtaatatta caaaatgaga taaatgaaaa aatcaatata gataaggata tgataagtaa
    10261 aaaatttcat gaaaatatga atgaatttca gatgttgaat aaggatcaag gagatataca
    10321 caaaaatggt cgcagtgtat caaagattga gtttgataat ggcagtatat tgtattacaa
    10381 acctcacagc cttgacaaag acataaaata tcaacaacta tacaaatatt tatgcgaaaa
    10441 agcaggaata tcctgtcggg aggtgaggtg cttatccaga cagacatatg gatgggaaga
    10501 aaatatagag aataaatcat gtaacacaaa agaagaaata gagcgttatt atttcaggct
    10561 gggcatccat ctgtttctcg ggtatgcatt gggagcaaca gatcttcatg gagaaaatat
    10621 tgttgcgtat ggagaacatc cggtgattat agatatggaa acatatcccg gctatattac
    10681 aaagaatagt ggaagtagta cagaagaaaa agcagaaatc aaaataagag aaaaaattat
    10741 gacatccgtg ttaaacacgg gtatccttcc tgttctcaca tggggaactg gaaacaatag
    10801 agttcttatg agtgctgtaa atatgcatgg caagataagg actccgttta agatgcctgt
    10861 tgtcaaagat gataaaacat caaatattca catagaatat gaacaggtag aatttgagat
    10921 aaaagagtgc attgtaaggt taaatgggga ggtggttaat tccgaagaat atacaggaga
    10981 gattatcagg ggatttcgga tggcttatac agaaatactg caaaatcaga aactcagaaa
    11041 tatgctgaaa actttttttc agggaaaatc cagagtaatt ttgcgacata cgcagcaata
    11101 ttatatgtat ctgtttgcgt cgttccatcc ggattatatg aaggaccgga aacaacgaga
    11161 ggaacttctt caggtattgc ataaaaaagg ggaaacccag ttgcagaaag aattaagaga
    11221 ttatgaaata cagagcctgc tggaactgga tattccatat tttgaaattg acggaaacag
    11281 cagatcaatt tttgatggaa atggaaaaga atatcaggga tatctgccat gtacacctta
    11341 tgaatcatgg atagagcata tgaagcaatt gagtcgtcag gatatggagc aacaatgtga
    11401 gtacatacga ttatctatgg gattattaaa tcatgggtat atcggcgaaa aaaatccgcg
    11461 atgggcagat gaaaattctt gtatacatca aattgcagag tggatttgca gaacagctgt
    11521 aattgaagaa gatgatattg gatgggctgg actgcatttc tgggataatg gatattggag
    11581 cctgaaacca tgtggtatgt atttatatga tgggattgcg gggattgttt tgtttctggc
    11641 aaaatacctg gaccagtatc aagattcgtc atgcaggaaa gacgtggaaa aaatctataa
    11701 actggctatt gaaaaattag aaaaatatac agatctgcga tgtgaacaaa atgaagtacc
    11761 tgaaccattg gcaacaggac tttacgatgg agagagttca attgtatatg tttatctgat
    11821 attatatgag atcacaggtc aggaaaaatg gatcaagaat gctcagaagc attttgagat
    11881 agtagctaaa ctgcttccaa aggatgaaaa tatggattat ctcagtggaa atgcaggcgc
    11941 aatcgtggct gccctgaaac tttatcaatt aactggagag attgaatatt gtacagctgc
    12001 gatagaaact gaaaaagatt tatggaaaaa aggtcagaga atggaagtgg gatatggatg
    12061 gaaactgaaa aatctgaaat atccgctgag tggactttct catggaaaca gtggcttttt
    12121 gatgacgtat gtggaacttt ataaaatgac atatgaccag gaatatctga aaaaaataaa
    12181 attgttgctt tcctatgagg atatcttata ttcagaagac ttgaaaaact ggatagatct
    12241 gcgtgattcg gacggacgaa agacaatgtg tggatggtgc catggtgctc ctgggatttt
    12301 acttagccgt atgtcgataa tggatattct gccagatgat aaacagatta aaaaggatat
    12361 cctgcgggca gtatccacat tatttcacaa tgagcgtgag aaaaaaatat gtctgtgcca
    12421 tggaatgaca ggaaatcttt taattatgaa aaagtatctg gagaagaatc cggatgatga
    12481 tttaagacag aaatacgaaa ggcagttttc gaacctgaag gaacaattgc aagatatgag
    12541 aagtcttatg gttactgaga cattaaatcc tgcatttatg aatggaataa ccggagttgg
    12601 aatggcaatg atgttgctga acatggatta gaaaaggcat ttacagcctt tctaatcagg
    12661 atgtctgaaa aaataagttt ttaacagttt ctttttctga cgattaatgt attgacggga
    12721 gacatgaaga attgatgcaa tttcggaatc tgttttatac tggtagaaaa acagagacag
    12781 aattttgtat tccatacttt ggacaggaaa gctttcgata tatgtagtta tatcataaag
    12841 agtttcatcg aatggattat ctgcctgtaa agtaagagaa cacgtatcaa agttttctct
    12901 ttcaggttct gacaaatggt atctgcataa agctctgtaa cgattttcta tagcggtctg
    12961 catatatctg acacattcac cttcggaaaa atttttgccg ttcaggtaag gcagtgtatt
    13021 aagcagagtc agatacaatt cctgtgtggc atcgtcccgt tccatacagt ggatgcggga
    13081 agcgtagctt ttgatcagag gttccatacg tttaagaatt tcttcatctg catttttgac
    13141 accagaatga taatcgtgaa ttaactgtaa taatgacttc ataagaaact acctcctttt
    13201 tggaggaagt agtcagaagt gactaaatca gaaactgaaa atagaaaaaa tatgaattga
    13261 ttgtagaaaa ataaaagaag cgaagtctga caacagaaga aataagcttc taaaaggaat
    13321 tgagttgaca aatcatgaga ttttctgtct ttctcagagg aactgaaatg ttttactact
    13381 gagaaaggag gtatgaagat atggaatcca cggttatgga aactgcaata tcgcagggaa
    13441 tctgggccgt cctggcagtt tttcttttga tttacattgt aaaatccaat gaacaaaggg
    13501 atgcaaagca ggaagaaagg gaaaagaatt accagacagt gattgagaat ttgactgaaa
    13561 aattccaaat tctaaatcag gttcagaatg atctgaaaga gattaaggat aatcttctta
    13621 ataaaaatta aatagaaaaa gaaatagaag ctctctctac aaaatgaatg tcacagtggg
    13681 gagggctttt atcattcagg caagaaaaca gattaatccg atatacaggc aaaaacactc
    13741 atgtccatta gaatacgttt tattctataa ttacagatgt tcatataaaa ggtggtacac
    13801 tataataata aatatcattg aatggaggaa aaagagatga aagaatacaa ggttataaca
    13861 gcactttttt tgtcagcagt aatgctgggt acagctccat taaccgtatg gggagcggag
    13921 agtttttcga caggggaatc tttcagtgat ggaacagaaa atattcctga catagtaaca
    13981 gattcggctc tgtctggtga atcttctgaa agagactatg agttaagtat agaaacaggt
    14041 acggatgtag agcttacaga aagtgatttt tatgatccgg aatttcgtgt agagaaatat
    14101 gtgaaagtca gaaattcagg aaaaaaagaa acaagagtcc gggtagatgc ttctggtctt
    14161 aagaattttg aggtagatga tcagatggca aagtggtcag aggattatga ggaacaggat
    14221 tccaaaagac tgctgaagcc gggagaaact ctggactttt ttgtactgcc aaagcaggaa
    14281 tacggaacat atgatgaaac gtttgatttc cttgcagatg acggaagcag atatccggtt
    14341 catatcacaa tgaatagaga gaagaaccca acggaaaaga agagtctgga aattaccgaa
    14401 aaatcttccg agagtttccc gataatgcac tggggatata agacacttcc ggaagctaga
    14461 atttatgttt tgaaaaattt tacggacatg gatatggaac tgtctttcga ttatagcaaa
    14521 gactgtagtg tatcattatc cggaaatacc agtctggcac ctggagagag tacagaactg
    14581 agcctttgtc cgcagatggg actgccagtt ggagaacatg atcttggagt aacagtgact
    14641 gcgaaaacag cgacaggaga gactataaca aagaagattt gggattcttt cagagtagat
    14701 tcaaggacat ttcagggact ggtggatacc attgaacctg tgactggaat taccaatggc
    14761 gtagaaaaaa ctgctgatgc tttacatttg ccatcggttc ttaaagtcta tggtgctgaa
    14821 gcggatggag aaaaaacgac attttctgcc gatgtaaaat gggatgtgga gaattgtgca
    14881 tataacccga aaaatacggc gcctcaaagt ttcacagtta acggacaatt ggaactgcgt
    14941 gaaggtgaaa acaatgaaga gctggatacg tctgtaaaga taaaggtaca ggtggatgcg
    15001 tacaaggcgt tgaacagacc ggtgattgat ccgacatgga ccagagtgat cacaaattat
    15061 gcagaacttt ctttaagaga tacttctaat gaagcagacg gatatttttt tgtagcagca
    15121 gaatctcaaa aggatctgga aaaaggaaat tatatcgcac aggtgaaggt cgcaaaatct
    15181 gaactgaatc attatcctaa actgaaatat attcctgaag ggacgcatta tctctattgc
    15241 agggcatata aagaggaaag tggtcatacg gagaaatatg gtgaatggtc tgaaggattt
    15301 ctgttaaagg taaatataaa gacaccaaat gcacctgtgg ttcagaaact acaggtgaag
    15361 aaaaatgacg ttaaaattat ccttggcagt aatacagaag aactggatgg ttatgatgtt
    15421 gttgctgcca gaagtaaaga cggggatgag ccatcagatt atataaaggt acaatgtaga
    15481 tattcaggaa acagcaagga actcattcta aaaggagtac cgaaaggaaa ctggtatatt
    15541 ggtgtacatg gctataaata tctggatgga tcaaataaaa aagtactgag taagtgggcg
    15601 gaagttcaaa aagtaacggt aaagacaagc cttgtaacag gaaaaccagc tgttaaatcg
    15661 gcaaaggttt ccagacaggg aacaaaaaga aaagtaacgg tgaagtttac tgtaccaaaa
    15721 tcctgtgacg gaacggactg ggtactggca aagaaagtat ctcaatctga agatggaagt
    15781 tatacatatg tcagcggtta tgcttatact aagaaaaatc agacgaaaac tacagtcatt
    15841 tttaaaaatg taaaacctgg agtttattat cttacaggac gtgcttatgt aaaaggatat
    15901 gcaaaaaatt atacgaaatg gtcagaggta aagaaagtag ttgtgaagta gaaaagtgat
    15961 ttagaccaga aatttaattt ttttctgcat atatatcaaa aagaatgttc ttatagtagt
    16021 attattaaaa atccccctta gacagagtaa aggaaactgt ttaaggggga tttttataat
    16081 gaggtatctt attggtatct aatgaatgac ttatgaggac ttaaatcatg aaaaatatta
    16141 gatgaactca atcgtattgt attgaaagaa tccgtccatg gacactaaag ttgtatcaga
    16201 atttgatttt ttaacattga cgttgcacac agctgccagt ttttttgtat ttgtatctaa
    16261 tgcaactgat tccagttcaa aggaattata aacctgtcct tcggcatttt ttgcgggcat
    16321 atttgtaaca aatccaaaat cagggtataa ggatgtcttt gtgctgagtt ttttcaagtc
    16381 gtagtgaagt agagtgtttt ttgttgtgac gacattctgg gcagccaggt ttgcattaca
    16441 tgttccaaca aaaagaccgt acttattatg atagaaaata tcctgggaaa caggttgtcc
    16501 tggattctct attgtaccga gataaacggc agaaggtttt tttgtgtcgc caaaggtgca
    16561 tttgtaaagt agcatttttc cgttttcaat agacaggagt aatgcagtat tagtttcgta
    16621 aaagtaattg attgctttta atcgtaatga ggcaggtgtt attgtataga ctgcttcttc
    16681 ttttccggaa ttacaattga gagcaacaac cttattgtca ccagcaacca cataaaatct
    16741 gttatcaaaa cagctcatgc cgttggcgtg tcctaataaa ccgtttgtat gtgcgataac
    16801 aggaattggt tttgcagcag tattcatata atcagaacaa tatcctagtg cactgtattg
    16861 ttgatattta actaaatatt tatagctatt atagccg
//
