LOCUS       c00019_gnlPro..        16204 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CNIFJDFK_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 19:36:25
            Original ID  :: gnl|Prokka|CNIFJDFK_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16204
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16204
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1647:6204]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1648..6204
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16204
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16204
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(13..1353)
                     /locus_tag="ctg19_1"
                     /transl_table=11
                     /translation="MKRIIILFFLCCTIPLIAQHTDPIQEAMANYDYETALSLIAQKKT
                     TPPLLLQKGKALRGLGLTTEALATYQEIICNDTTNTRAFIEAAECCRALAKYNQALKYY
                     EHALDLNPENKYVRIQYISLLLSQQKFSEALGESSLMTEKDSSAIVLHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIRRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVDYLEKTIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKERYQRYDKQNHKLLYDMAYIYFYDLKDKKNAERYLEAFLKTRPKDTKEEAEMN
                     ERGELVLGKSNYYNAAAKWLKDIQSKQKIEDFFQNSSPQLPLPKKDK"
     CDS             complement(1648..2808)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-153, bitscore:
                     499.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLGFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2810..3241)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.2e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(3266..4186)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="OAD_gamma (E-value: 1.4e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(4218..5771)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="CT_Btheta (E-value: 4.1e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(5800..6204)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 6.6e-24, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(6380..7378)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNTFHSKELFLIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRTNDYFPVNWLRVRNSLHSMEKTEDRFSPSRM
                     RQIKKGLKNGARVEEAHTVEEIHDFSRMLHKIYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWSWLNKLLVKFYV"
     CDS             7747..10797
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="MVQVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNF
                     SIDLPAGRKELVISYIGYKEQTVTVTGNGPVNVKMISDTQALDEVVVIGYGAVKKRDLT
                     GAVASVKSEDITMNPGTNPMEALQGKVAGLDITRESGQAGSGVKMQLRGNRSLTASGNP
                     MFIIDGMPGDYATLNPNDIESIEVLKDASSTAVYGSSGANGVVIITTKGGKEGKLTANF
                     NAFFGINSWSTMPEVRQGETYMEGLRTAHKNAGTYVDDANMFTNPAYYEAYQNGKYIDW
                     VDELLHTGTVQNYSLSVSGGTKNTKAYMSMNFSDENGQYNDDNYKLYSTNIRIDHTINK
                     WFTTGISIQASYVHQNKPFAKIQDGMTAIPYGEIYDENGNVNPYPIEGDAGYLNLLMNN
                     KSNWRNQSQNTKLYVNPYIIITPIKGLTWESRVNGTLTYSRSNSFQGDGSYNFYKAGGN
                     VETDTNAKITQNRSYNYKWENIVTYNFNIAKIHEFTLTGVSTWNHNQTDNTEMTGTGIA
                     NNKYLWEGLEKAAVQKNSSSYTMSKGVGLVGRINYSLLGRYLLSASIRRDGSSRLAKDH
                     KWSNFPAVSLGWRISDEKFMESTRNWLDNLKIRVGYGISGTASIDPYSSSSSLESGWLT
                     LGGEKTQIYNLTKIIANPELTWERSKNTNIGIDASFLNNRINVTLDMYKTKTEGVIWKK
                     SLPVVNGSYSSKEQYLTNINLCETKNKGLELALNTRNIETKNFQWTSALTFAYNKEEIT
                     KLTGTANDKVINGDYTYAVGSAINSFYHYKLDGIWQKGEEADAAVFGLKPGSIKINVPD
                     MVRHTDTDGSVYYTKVNADGQEIRYDASNTYSVSADDYQVLGHNSPDWTMGFQNTLTYK
                     DFDLSIYMYMRWGQMLKYSVLTDYDPTGLNNYPTYFNVWSETNPSNDFPAMDASIKDKL
                     SYYPGFAALSYVDGSFFKIKNITLGYTMPDKLAKKLGLGKLRVYGTITNPFVIAKSHLL
                     KDYDPEMNGGLNYPLTKQLVFGLNLSF"
     CDS             10817..12847
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MKKLVYNVALALCAMVTINSCSLDEYNPMEVTGEETLATFDGWYG
                     MQTQCYNPIYSQLYTVTDFLSVAEAGTDTWLTANNNDNSKELFYYESLTPSKDKAWDKL
                     FMQAYTALGICNTVINRAESVEGNADDIRVLTAEARCLRGFYHLILTTYFGPITLCMNE
                     AGNNIVLEPKRNTLSEIYSYIIDDLKYAADNLNTTPYGNNRARVSKKSAMGLLARAYIQ
                     GAGQGLSENGVSYWQRAADVAESFIADTEAGGGTYGGYLYKDISDMWADGNNRTNKEAL
                     FVAAGCDAGDDDAWDYSNAGYNKLFTYTYWNQTNLSDISKITSDKQNYFYGRTNNGNCA
                     PSKYLLDCFEPTWDKRWENSFQTAFGAFSMEKVAWIPYTKNIVTLTSDLCQKYGIDASH
                     VGEKIYPYVDCDGKTMSHGGNQYTASVWPKGVTTGDVSTLMTPKKVYVIDYPLPADDNR
                     FFLYLSKEPLSAEDKKDRVYACVNIDDLFDANGNYVKTQNDMPGSYDRTSKVYATYPCL
                     NKFIWSYEGVYYGSNLQIRNGDIFVMRMAEVYLIAAEAEQHLGNGTKAAGYLNTLRARA
                     ARSGALESSYKLTTVTEEDIYDEYARELCGEHSRWALLQRHQAFSTRLAKYNKRAASSF
                     KSYNIWRPISQTFLQQIDNAEEYGDNGYGTTAKSGLDGFLQ"
     CDS             12961..13503
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(13600..13824)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MKKRITQDDYVKANRKASREAEIEMYGHPICHQRVHQSKKVYNRR
                     KIKAADKKLPYFFVFKIASLSSRHSDTIQ"
     CDS             13947..14483
                     /locus_tag="ctg19_12"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             14486..14821
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="MGAAKANNSKDTYLATAVTFIVIGALFLIDKLIHFSSIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLTLLIIGIV
                     LFWFAKR"
     CDS             14829..15623
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_14"
                     /sec_met_domain="F420_oxidored (E-value: 5.2e-14, bitscore:
                     43.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQAVSKDAKLYIVSLKDDALVDLLPQITEGKQASLLVHTAGSIPMS
                     VWEGHAERYGVFYPMQTFSKQREVKFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMSNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             15604..16125
                     /locus_tag="ctg19_15"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFEGLGVKDLYMGSAVKIHDYRAFRDKYGLTDDE
                     ILYMGDDVPDIEVMCECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     LWMVEDAFGW"
ORIGIN
        1 tatagttctt atctatttat ctttctttgg gagaggaagt tgtggagagg aattttgaaa
       61 gaagtcttct atcttttgtt tactttgaat atctttcagc cacttggcgg cggcattgta
      121 ataattggat tttcctaaaa caagttcgcc tctctcgttc atctccgctt cttctttagt
      181 gtctttagga cgtgttttta ggaatgcttc caaatagcgt tccgcatttt tcttatcttt
      241 caagtcatag aagtatatat aggccatgtc atacaatagt ttgtggtttt gtttgtcata
      301 ccgctggtag cgttctttga tggatgcaat ctgttctttg tacatttgtg ccatcttgta
      361 acagtcggtc atcccgatgt aaagtcgagt catactgcta tctttgggaa tggatagatc
      421 aatggttttt tccagatagt ctacgccctc ttttttccag gaagttttgg aacaggcgcg
      481 accgaggtaa taaaggagat tgatattgtt gggatcatat ttacgggcga cttccaaaaa
      541 atcatgagct tcatagtact tctctgctgc atagtaactg atgcctaaat aataacaagt
      601 atgaaaagaa ctgtctcctt ggctgacaag atattcataa cgccggatag cagtggggta
      661 gtcttgtttc aagcagtacg ctaaagcgtt ctgccggttg acggaaatgt tggtactgtc
      721 aatttgccgg tatttttctg tagcttcgat ggcttcgtcg aaataagaac cggatatatt
      781 tagagcacct agtttgctgg ctgccagata atcgtcggga tatttagcct ggatattgta
      841 atagcaacct gcagcgggaa gaagttcgcc cattccttca aagctttgag cttgtagatg
      901 caggacaatg gcggaactgt ctttttctgt catcagacta ctttcaccaa gcgcctcgct
      961 aaacttctgt tgggagagaa gcaagctgat atattgaata cgtacatatt tgttttccgg
     1021 attcagatca agtgcatgtt cataatattt tagtgcttga ttgtatttag ctagtgctcg
     1081 gcaacattcg gccgcttcaa tgaaagcacg agtatttgta gtatcattac agataatttc
     1141 ttgataggta gcaagtgcct ctgtagtgag tcctagtcca cgcaacgctt tgcctttctg
     1201 taatagcagg ggaggggtag tctttttttg agctataaga gaaagggccg tctcataatc
     1261 gtagtttgcc atagcttctt gaatagggtc tgtgtgttgc gctattagag gaatggtaca
     1321 acaaagaaag aacagaatga taatccgttt cataatattt tattttagtt gtttgactta
     1381 tctgctgcaa gttactaaaa atattatatt tacgaattat tcgtagatta ttttggatag
     1441 attaacggaa tgataagaga aggtaacaca acagtgcgca atacaataca tggggcatgg
     1501 tagctacagt cttttttaca gcaagtcctt ataatgaaaa atcaccttta ctactataat
     1561 gtagcaaagg tgatttttat aaattcaagg cttttaggat agtcttattt tttattttaa
     1621 gaactgttca aacagcctcc ttatatctta catcaagaat ccgagcagga taccggcagc
     1681 aacagctgaa ccgatcactc cggcaacgtt cggacccata gcgtgcatca acaaatagtt
     1741 ggtcgaatcg tattccaaac caatcacttg tgagatacgt gcagagtcgg ggacagcaga
     1801 aacccctgca ttaccgatca atggattgat cttgttgccc ttcttcaaga agatattgaa
     1861 tatcttaacg aagattacac cggatgcagt tgcaatgatg aatgacaatg caccgagggc
     1921 gaaaatcttg atagaatcga gcgtcaggaa ttcggaagct tgcgtagaag cacctactgt
     1981 cagacccaac aggatagtga tagtatcaat caacggaccg ctagctgtat tggcaagacg
     2041 acgggttaca ccactttctt tcaacaggtt accgaagaac agcataccca acaaaggtag
     2101 accggaagga accaggaagc aggtcagcaa caagccgata atcgggaaaa taaccttctc
     2161 cgtgtgagaa acggcacgcg gcggtttcat gcggatgaca cgttcgttct tggtggtgag
     2221 cagacgcatg ataggcggct gtatcaccgg aaccaacgcc atataggagt aggcggacac
     2281 cgcaatggct cccatcaggt taggtgctag cttggaagaa aggaaaatgg ccgtcgggcc
     2341 gtctgctcca ccaatgatac cgatagcgcc ggcttgcatc gggtcgaagc ccatttccaa
     2401 tgcgatcatg taagcaccga agataccgaa ttgtgcagca gcaccgatca acatcaattt
     2461 cggattagag ataagtgccg agaagtccgt catggcgccg atgcccaaaa agatgagcgg
     2521 cggataccag ccggaagtta ctccctgata caatatattc aatacggaac cttcttcata
     2581 aataccgact ttcagtccgg catccatatt aaaaggtata ttaccgatca gcataccgaa
     2641 gccgatagga atcagcagca tcggttcgaa ctctttggct accgccaaat agatgaaccc
     2701 caaacccaca agaatcataa cgacatgccc tacagtagca tttgcaaagc ccgtgtatgt
     2761 ccagaagtcg gcgaggttat ttcctaaaaa gtttataaaa tctcccatat tattcaataa
     2821 ttacgaggtc attaccttca agaacagagt ctcccttgtt gacgttgatg gcagtaatct
     2881 taccgtcctt atccgcattg atattgtttt ccatcttcat ggcttccaat atgataatgg
     2941 tctgtccttt ctttacagta tcgcctacat tcactttgat gtcgaggata acacccggca
     3001 gcggagattt cactcctgat tttccggtag acggagcagt cggtttcact acctgagtag
     3061 gagcagtagg agcattaggc ataggacgta ctgttacagg tttggcagca ggcttcggct
     3121 gtttctccat ttccacttta tagtgtgtac cgttcacttc tacatgagcg atattatctt
     3181 caatatctcc gatggttact ttatatgagt taccgttgat tttatattta tattctttca
     3241 tcgttttaac tttttaaaag gtgacttact ttctgggagg agtttcacgc aaagtgtaaa
     3301 tcttcgaact ccatggtgag taactgcgtt ttacgcgagt gatggtcagt accgtttctt
     3361 ctacgtcgtg cacttcatcc tgcatttcgt gcaatgccat agaaatcgca gcgtaaactt
     3421 cgcccggagc ctgtgacagt tccttagctt catgcttgtc aatgccttta gatttcatag
     3481 cattgcgctt gctcaaattt acagctactt ttcctacaat cttgaaggca ataaagagaa
     3541 gaatcaatcc gcagaatact acactcatgg cagagatgga catgccgaca ccgtcagcat
     3601 catgctcttc gaatttttcc atcttggcat tgctgtcaag agttttgttg ttcgtactcg
     3661 gggtcacgta tttgtcacca cttccacctt ttacctccca ctccgctgct ccgtcgctga
     3721 cacgagcgta tgactggttg gggccaagaa cacctgcggg cactacaatc tggtcgagca
     3781 gctttctacc ggagtcaaac agaccgatcc agttggccgt ttccggattc agcttgaagc
     3841 tggtgtggaa agtaccgcgg ttaggttcgc catctgccca gaatagtgca tgttgacgtg
     3901 gcttcactaa tgtaagtata tcacctttcg ggataaagta agtaactgta tcgcccggtt
     3961 ggctgcttac tttcaacaag caagctgcca ggtcggcgct accgaatgat ttattgaata
     4021 tttcaatcca tgcgctgtgc aatccgtagt catcttgaaa attattctga ttgtctatca
     4081 ggatttcgtt cagtaccagc ttgttgttcg acttttgctc tccacaagaa gtcagcccaa
     4141 tcagcaacag caaagaaagg aatattccga ttttggtttt gttcataatc gttcttgttt
     4201 taatgtgaaa agtaggatta caacggaata ttaccatgct tcttagccgg attactcaat
     4261 ttcttagtct gcaactgctg caaagcacgg attacgcgga aacgtgtgtt gcgtggttca
     4321 atcacatcgt cgatgtagcc gtatttggct gcattgtaag gattggcaaa cagtttcgtg
     4381 tattctgctt ctttttcagc aaggaattga gcgggatttt cctgatcttt ggcttcgcgt
     4441 gcgtacaata cttctactgc tcctgctcca cccattactg cgatttcagc agtcggccat
     4501 gcgtagttca tgtcaccgcg aagttgctta cagctcatta cgatgtgaga accaccgtag
     4561 gatttacgca atgtgatagt aaccttaggc acagtagctt caccgtaagc atacaatagc
     4621 ttagcaccat gaaggataac gccgttgtat tcctgacctg ttcccggaag gaatcccggt
     4681 acgtctacta acgatacgat aggaatattg aatgcatcgc agaaacgaac gaaacgtgca
     4741 cccttacgag atgcgttgct gtcgagcaca ccagccagat acttaggctg attagcaacg
     4801 atacctaccg attgtccgtt gaaacgggcg aaaccgatga tgatattctt tgcataatct
     4861 ttctggattt caaggaattc accgttgtcc acaatagcgc cgatcacttc gtacatgtca
     4921 tacggtttag tagggctgtc ggggataata tcattcaaag aatcttccaa acggtcgatt
     4981 gggtctgtac aatctacata aggagcttct tcaaggttgt tttgaggaat ataactcaac
     5041 agtttacgaa tcagttcgaa accttcttct tctgttttag cggtgaaatg agtcacacct
     5101 gatttagtgg agtgaacgct tgcgccaccg aggttttcct ggctaacgtc ttcacctgtt
     5161 acggtcttca caacttttgg tccggtaagg aacatgtaag aagtaccttc catcattagc
     5221 gtgaagtcgg tcaaagccgg agaataaaca gcaccgccgg cacaaggacc gaagatacct
     5281 gaaatctgtg ggataacacc ggaagcaagg atattgcgtt ggaagatttc tgcataacct
     5341 gccaaagcgt tgataccttc ctgaatacgt gcaccacccg agtcgttgat accgatacag
     5401 ggagcgccca tcttcatggc ttgatccatg attttacaaa ttttcaatga catcgtttct
     5461 gacagtgaac cggcagaaac agtgaagtct tgtgcgaaca catataccag acgtccttcg
     5521 atcgtaccgc agccggttac tacaccgtct cccgggtaat gttttttctc catgccgaag
     5581 ttcgtgcatc tgtgctcaac gaacatgtcc atttcttcga agctaccctc gtcaagcagc
     5641 atagccagac gctcgcgtgc tgtgtatttc cctttttcgt gttgcttcgc aattgctttt
     5701 tcaccgcctc cgatacgtgc tacggcacgg cgttcaataa gctctttaat tttttcaagt
     5761 tgattactca tgagttcttg ttggttttag agtttatgat taatgttcgc agagttctgt
     5821 taacacaccc aaagttgatt tcgggtgaag gaaagcgata ttcaaacctt cagcaccttt
     5881 gcggggagct ttgtcgataa ggcggatttc tttgccttct gcctctgcca gcgcattggc
     5941 tacgccatct tctacagcaa atgcgacgtg gtgaacgcct gcacctttgt tttcaatgaa
     6001 tttggcaata gtactctccg ggcaagtagg ctccaacagt tcaatttttg tttcgcccac
     6061 ttttaaaaaa gcagttctta ctttctgatc ttccactgtt tcaatgttgt aacacttcag
     6121 acctaataca ttttcgtagt aaggaagggc ttcttcgatg ctttttacag caatgcccag
     6181 atgttcaatg tgtgaaatct tcataactat acttttttta tttggtttta aatctgtgct
     6241 tataaggcat aaaacagcac aaagaaagac atttcttatc taataaagaa atatttctgc
     6301 atttaattat tggattatta aacagaaaaa atggtgggaa aggagcataa aacattgttt
     6361 tgtaatcttg agattacatt tagacataaa acttgactaa gagtttattc agccaactcc
     6421 aattgacgcg gaaccaacgg cgggtactgc tttgttttcc tccgaagcga agaacgaaat
     6481 cacgataacc gtgtttacgg aacggaagtc ctacatccat aaattccatg tggcggaatc
     6541 cccgttggtg tgcgtcttcc aatgctttcc aaacggctag cacacccgga tattgaagtg
     6601 cgtatgtctt tctcattcct cccgaaaacc aaaggtatgc gtcgtctccc gaatagatac
     6661 agacagaacc gccaatgatt ttctctttgt atttcacaac gaatattttt gcctgttgtc
     6721 ctttgattaa catattgttc atgtggcgga aaaaatcgtt ggccgggaaa tatctgcgta
     6781 tgcgggagga ataaatcttg tgcagcatcc gtgagaaatc gtgtatctct tccacggtat
     6841 gtgcttcctc tactctggct ccattcttga gtcctttttt tatctgacgc atacgcgacg
     6901 gactgaaccg gtcttctgtc ttttccatac tgtgcagcga attgcgtacc cgcaaccagt
     6961 tgactgggaa ataatcgttg gtacggaaaa cccgataacc gaacatcgaa ttgttcaggt
     7021 tccggaattc gatcaggaca cagctgcgcg atgcttcttg tgtgagatgt tcgagcatat
     7081 cgccgaagac ttcttctgcc ttttctttgt tggtcgaaag agactcgtcc agaaattcgc
     7141 cttcactata tactacacaa tgtttcacta aagaagaagg gagccacttc tttgctttgc
     7201 ggatggcagc aagcaggcgt gccaccggtc tgccgtcttc tgttgccact attaataaag
     7261 gagtataccc aggagttgct tcataaatca gaaataactc tttggaatgg aaggtatttt
     7321 ttcccggcaa ttcaggaata tccttcccat gataatatgt tgttagtttc agtggcatct
     7381 aggtacaaat ttacactttt tattctttat tcaacaacaa aataaagaat ttgttggagc
     7441 tgcttgaagt aaagtataat atatcgttgc gtatttaatg gagaaaatgt attttatagg
     7501 agaaatatgg tatgaaaagt gagtacgtat taaaattagt ttcgtcttta attaagatta
     7561 taatcgaata gtttttgcaa aacaacgaga attaatatta actttaaatt agaacgaatg
     7621 agatgtaatg catttgttga agcatggaag aatcatcata gacgcgcttc catgatttta
     7681 gggctgtctt tattgtctgc ccctctgtca tattctgtgt atgcagaaga tggagtttct
     7741 aatactatgg tgcaagttgt cacacaaacg aaaactgtga aaggaactat cattgatgaa
     7801 agcggggagc cgttgattgg ggtttctatc gttgtgaaag gaacaagtac aggtacgatt
     7861 accgatttta acggtaactt ctctatcgat cttccggcgg gaagaaaaga actggtcatt
     7921 tcttatatcg gttacaaaga acaaacggtg actgtgacgg gtaacggacc ggtcaatgtg
     7981 aaaatgattt cggatacgca ggcattggat gaagtggtgg tcattggcta cggtgcagtg
     8041 aagaaacgtg atttaacagg ggcggttgct tcagtgaaat cggaagacat tacgatgaat
     8101 ccgggcacaa acccgatgga agcgttgcag ggtaaagtag cgggattgga tattacgaga
     8161 gaatcgggtc aagcgggttc aggagtgaaa atgcaattgc gcggtaaccg ttcattgaca
     8221 gcaagtggta atcctatgtt tattattgac gggatgccgg gtgactatgc gacactgaat
     8281 ccgaatgata ttgaatctat tgaagtgttg aaagatgctt cttctacggc tgtttatggt
     8341 tcttccggtg ccaatggtgt tgtaatcatt actaccaaag gcggaaaaga aggaaaattg
     8401 actgctaatt ttaatgcttt ttttggtata aacagctggt ctacaatgcc ggaagtccgc
     8461 caaggagaaa cctacatgga gggcttgcgt acagctcaca aaaatgcggg tacttatgtg
     8521 gatgatgcca atatgtttac taaccctgct tattatgaag cttatcaaaa cgggaaatac
     8581 attgactggg tagatgaatt gctgcatacg gggactgttc agaattatag tttgtcggtt
     8641 tcaggaggta caaaaaatac aaaggcctat atgtctatga atttctccga tgaaaacgga
     8701 caatacaacg atgataatta taaattgtat tcaacaaata ttcgcatcga tcacacaatc
     8761 aataaatggt ttactacagg aattagtatt caggcatctt atgtgcatca gaataagcct
     8821 tttgcaaaga ttcaagatgg tatgacggct attccttatg gtgaaatcta tgacgagaat
     8881 ggcaatgtta atccttatcc gattgaaggg gatgccggct atttgaatct tttgatgaat
     8941 aataaaagta attggagaaa ccaatcccag aatacaaaac tgtatgtgaa tccttatatt
     9001 ataataactc cgattaaagg attgacatgg gagtcacgcg tgaatgggac gttgacttat
     9061 tcccgttcga atagtttcca gggagatggc tcgtacaact tttataaagc gggaggaaat
     9121 gtagagacag atacaaatgc caagattact caaaacagat catataatta taagtgggaa
     9181 aatatcgtaa cttacaactt taatattgct aagatacatg aatttacgct tactggtgtg
     9241 tctacctgga accataacca gacggataac acggaaatga caggaacagg tattgctaac
     9301 aataaatatt tgtgggaagg attggaaaaa gctgccgttc agaaaaattc atccagttat
     9361 accatgtcta aaggagtcgg attagtagga cgtatcaact actctttatt gggtaggtat
     9421 ttgctttctg cttctattcg tcgggatggt tcttcacgtt tggctaaaga tcataaatgg
     9481 tctaatttcc cggctgtttc attgggatgg cgtatttctg acgagaagtt tatggaaagt
     9541 acaagaaact ggttggataa tttaaaaatt cgtgtgggtt acggtatttc tggtacggcc
     9601 agtattgatc cttattcttc ctcttcttct ctggagtccg gatggttgac attaggtggt
     9661 gaaaaaacgc agatttataa tctcactaaa ataatagcta atccggaact gacatgggaa
     9721 cgttcaaaga acaccaatat cggtattgat gcttctttcc tgaataatcg tatcaatgta
     9781 acattggata tgtataagac taagacggaa ggtgtgatat ggaaaaaatc attacctgta
     9841 gtgaacggtt cctatagttc taaagagcaa tatctgacca atataaactt gtgtgaaact
     9901 aaaaataaag gtcttgagct tgctttgaat acccgcaaca ttgaaactaa aaattttcaa
     9961 tggacatcgg ctctgacttt tgcatataat aaggaagaga ttacgaaact gaccggaact
    10021 gctaatgata aagtaatcaa tggcgattat acgtatgcgg taggtagtgc aatcaactct
    10081 ttttatcact acaaattgga tggtatctgg cagaaaggtg aagaagctga tgctgctgtg
    10141 tttggactga agccgggatc tataaagatt aatgtgcctg atatggtgcg gcatacggat
    10201 acggacggta gtgtctacta tacgaaggtg aatgctgacg gacaggaaat ccgttatgat
    10261 gcttctaata catattctgt gtctgctgat gattatcaag tattgggaca taactctccg
    10321 gattggacaa tgggtttcca gaatactttg acatataaag attttgattt aagtatttat
    10381 atgtatatgc gttggggaca gatgcttaaa tattctgtat tgacggatta tgacccgaca
    10441 gggttgaaca actatcctac ttatttcaat gtatggtctg aaacaaatcc ttcgaacgat
    10501 tttccagcca tggatgcttc tatcaaggat aagttgagct attatccagg ctttgcagcg
    10561 ttgtcgtatg tagatggatc attctttaaa ataaagaata taacattggg atatactatg
    10621 cctgataaat tggctaaaaa attgggattg ggcaagctcc gtgtgtatgg aacgattact
    10681 aatccattcg ttattgcaaa aagtcatttg ttgaaggatt atgatccgga aatgaatggt
    10741 ggtttgaact atccattgac aaaacagtta gtctttggtc ttaatctttc attttaattc
    10801 tctaaactga taaataatga agaaattagt atataatgtg gccttagcat tgtgtgcgat
    10861 ggttactatc aattcatgtt cattggatga atataatcca atggaagtta ccggcgaaga
    10921 aacgttggct acgtttgacg ggtggtacgg aatgcaaacc cagtgttata atcctattta
    10981 tagtcagttg tatactgtga cagacttttt atctgttgca gaggctggta cggatacgtg
    11041 gttgacggca aataataatg ataactcaaa agaactcttt tattatgaat ctctgacgcc
    11101 gagtaaagat aaggcatggg ataaattatt tatgcaggcg tatactgctt tggggatatg
    11161 taataccgtt ataaaccgtg cggaaagtgt agaaggaaat gcggatgata ttcgtgtgtt
    11221 aacagccgaa gcacgttgtt tgcgtggttt ttatcatttg atattgacta catattttgg
    11281 tccgatcact ctttgtatga atgaagcggg aaataatatt gtgttggaac ctaaacgtaa
    11341 tacgttatct gaaatttatt catacatcat tgatgatttg aaatatgctg cagataatct
    11401 gaatacaact ccttacggta ataatcgtgc ccgtgtttca aaaaaatcgg ctatgggact
    11461 tttggctcgt gcctacatac aaggagccgg ccaggggttg agtgagaatg gtgtttctta
    11521 ctggcaaaga gcggcagatg ttgcagaaag ctttattgcg gatacagaag ctggcggagg
    11581 tacttatgga ggttatcttt ataaagatat atcggatatg tgggctgatg gcaataaccg
    11641 tactaataaa gaagcgcttt ttgttgcagc aggttgtgat gccggtgatg atgacgcatg
    11701 ggattattcg aatgcgggat ataataaatt gtttacgtat acttactgga atcagacgaa
    11761 cctgtcggat attagtaaga ttacatctga caaacagaac tatttttatg gacgtaccaa
    11821 caatggcaac tgcgcaccat ctaaatattt gctggactgc tttgaaccaa cttgggataa
    11881 acgttgggag aattcattcc agactgcttt cggggcattt tctatggaaa aagtggcatg
    11941 gattccgtat actaagaata tagtgacttt gactagcgat ttatgtcaga agtatggtat
    12001 tgatgcttct catgtgggtg aaaaaattta tccctatgtt gattgtgatg gcaaaacgat
    12061 gtctcatgga ggaaatcagt atacagcatc tgtgtggccc aaaggggtga ctacagggga
    12121 tgtatcaaca ttgatgactc ctaaaaaagt atatgtaata gattatccat tgcctgcgga
    12181 tgataatcgt ttctttcttt atttgtccaa agaacctttg tcggcggaag acaagaaaga
    12241 ccgtgtttat gcatgtgtga atatagatga tttgtttgat gcaaatggca attacgtgaa
    12301 aacacagaat gatatgcctg gcagttatga tcgtacttca aaagtatatg caacataccc
    12361 atgtctgaat aagtttatct ggagttatga aggagtatat tatggaagta acttgcaaat
    12421 ccgtaatggt gatatttttg tgatgcgtat ggcagaagtt tatttgattg ctgccgaggc
    12481 tgaacaacat ttgggtaatg gaacaaaagc tgcaggatat ttgaacacgc ttcgtgcccg
    12541 tgcggctcgt tccggagctt tggagtcgtc ttataagctg actactgtca ccgaagaaga
    12601 tatctacgat gaatatgcac gtgaactttg tggagaacat tcacgttggg cattgttgca
    12661 gcgtcatcaa gcattctcaa ctcgtttggc gaaatacaac aaacgtgctg cttccagttt
    12721 taaatcttat aatatatggc gtcctatatc acaaacattc cttcaacaga ttgataatgc
    12781 tgaagaatat ggagacaatg gatatggtac aacagctaag tctggtctgg acggattttt
    12841 acaataacaa tatagattaa attttaattt tcggagggga tatgtcgtga tgatatgtcc
    12901 cttttttcta tattttctat atctttgtgt aatcgaacag aacttttaaa aagcggaact
    12961 atgttagaag aaattttagc ttacaacaag caatttgttg agaacaaggg atacgaatcg
    13021 tatattacca ataaatatcc cgataagaaa atagctattc tttcctgtat ggatacccga
    13081 ctgactgctt tgctgccagc agcattagga attaagaatg gcgatgtgaa aatgataaaa
    13141 aatgcaggtg gcgttatttc ccatcctttc ggtagcgtga tacgtagttt gcttgttgct
    13201 atttttgagt tgggagtaga ggaaataatg gtgattgctc attctgattg tggagcttgc
    13261 catatgcata gtgaagaaat gctcgaaaaa atgaaagcac gcggaatcaa tccggattat
    13321 attgacatga tgcgtttctg cggagttgac tttcattcgt ggctggatgg tttcgaagat
    13381 acggaaaagt cggtgagagg aacagtcgat tttattgtac gccatccttt gatcccttca
    13441 gatgtgacag tctacggatt tattattgat tctacgaccg gggaattaac gcggattgta
    13501 tagataatta gatagatagg taaataggta aatagataaa ctgctttttt aatcccctaa
    13561 atatagtgac gctatcctat catgatagtg acgccattct tattgtatag tgtcgctatg
    13621 tctggaggat agtgacgcta ttttgaagac aaaaaaataa ggcagctttt tgtcggctgc
    13681 ctttatcttt ctgcggttat atactttctt tgactggtgc actcgttggt gacaaatagg
    13741 gtgtccgtac atctcaattt ctgcctcacg gctagcttta cgattcgctt taacgtaatc
    13801 gtcttgtgta attcgctttt tcataatgaa attatttctc tgtgcaaaga tacaatatat
    13861 tcttcattta gtataaactt ttatttccta ttacgctcgg tttgcattat ctttgcatac
    13921 attaatcaaa tgaaaccgga aataatatgg aaaatttcag tgaattaata aagaaccgtc
    13981 gtagtatgcg gaagttcacc gatgaagaat tgacacaaga tcaggtagtt gcattgatga
    14041 aagcagcttt gatgtcccct tcttccaaac gtagtaatag ttggcagttt gtagtggttg
    14101 atgataaaga ggtattgaaa gaattgtctc attgcaaaga acaggcttct tcgttcattg
    14161 ccgatgcagc tttggcgatt gttgtaatgg ccgatccgtt ggccagcgat gtttggattg
    14221 aagacgcttc cattgcttcc atcatgatac agttgcaggc tgaagatctt ggcttgggaa
    14281 gttgttgggt gcaggttcgc gaacgtttca ctgccaccgg aatgccttcc gatgaatttg
    14341 tccatggaat tttggatatt cccttgcaac ttcagattct ttctgtcatt gctatcggac
    14401 ataaagggat ggaacgtaaa cctttcaatg aagaacatct tcaatgggag aaaattcata
    14461 ttaacaagtt cggaggaaaa taagtatggg agctgctaaa gcgaataata gtaaagatac
    14521 ctatctggct actgctgtta cctttatcgt tatcggagca ctttttctga tcgataagct
    14581 gattcatttt tcttccattg ggctaccctg ggtgatgaat aaggacaata tgctattgta
    14641 cgcctcgatc tgtttcctta ttttcaaacg cgataaatca attggttttg tgttgcttgg
    14701 gctttggtta gtgatgaata tcggtttggt catgtcctta ttgggttcgt tatccggata
    14761 tctgttgcca ttgacactgc tcatcatcgg aatcgtttta ttctggtttg caaaacgata
    14821 agagaataat gaaaagaagt atagaagata caccgatcgt gtttatcggt gcaggtaact
    14881 tggctactaa tctggcgaaa gctctttatc gtaaaggttt ccgcattgta caggtatata
    14941 gccggactat ggaatctgcc cgtaccttag ccgagaaagt agaagctgaa tatacaacag
    15001 atttacaggc agtctccaaa gatgcaaaat tgtatatcgt atcgttgaaa gatgatgctt
    15061 tagtagattt gttaccgcag ataacagaag gaaagcaagc gtctttgttg gtgcatacgg
    15121 caggaagcat tccgatgagc gtttgggaag ggcatgcaga acgttacgga gtattttatc
    15181 cgatgcagac attcagcaaa caacgtgaag ttaaatttca ggaagtgcct ttctttgttg
    15241 aagcgaaaag gccggaagac gtggaattgt tgaaggctgt tgccgccaca ctttcggaaa
    15301 aggtctacga ggcttcttcc gagcaacgta agagccttca tttggctgct gtttttatct
    15361 gtaacttcac caatcacatg tatgcattag cagctgattt gcttgaaaaa tacaacttgc
    15421 ctttcgatgt catgcttccg ctgatagatg aaacagcacg taaagtccac gaattggcgc
    15481 cacgtgatgc acagaccgga cccgctgttc gttacgatga gaatgtgatg agtaatcatc
    15541 ttgccatgtt ggtagattct ccggcattgc aggaaatata taaactaatg agcaaaagta
    15601 tccatgagca ccatcaatta tgatttatcc cgtatcaaag ctttagcttt tgatgtggac
    15661 ggagtattga gttcgacaac cgtacctttg catccttccg gagaaccgat gcgcacggtg
    15721 aatatcaaag atgggtacgc catccagttg gctgtgaaaa aaggacttca catagctatc
    15781 atcaccggtg gccggacaga agcggtacgt atccgttttg agggactggg agtgaaggat
    15841 ttatacatgg gttctgctgt gaagatacat gattatcgtg cttttcgtga taagtacgga
    15901 ttgaccgatg atgaaattct atatatgggt gatgacgtgc cggatattga agtgatgtgt
    15961 gagtgcggac tgccatgctg cccgaaagat gccgtgccgg aagtgaaatc cgttgcaaag
    16021 tatatttctt atgcagacgg tggtcgtgga tgcggacgtg atgtagtgga gcaggtgctg
    16081 aaagctcacg gtctatggat ggtggaagac gccttcggtt ggtaacttaa tcataaataa
    16141 tcgttgttta ataacgaata aaaccatgct tgataactta aataaatatc agattatatt
    16201 agct
//
