LOCUS       gnlProkkaLLMEOKLN_14   16319 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LLMEOKLN_14.
ACCESSION   gnlProkkaLLMEOKLN_14
VERSION     gnlProkkaLLMEOKLN_14
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 23:58:09
            Original ID  :: gnl|Prokka|LLMEOKLN_14
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16319
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16319
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9725:15705]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9726..15705
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16319
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16319
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(2..187)
                     /locus_tag="ctg14_1"
                     /transl_table=11
                     /translation="MSTIEFNTYITDAEWEVMRVVWANDRVTSKKVISVLQEKMDWTQS
                     TIKTILGRLVGKGVLNT"
     CDS             1265..1942
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171.2; E-value:
                     4.8e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_2"
                     /transl_table=11
                     /translation="MQININQLSKSYKDKTILDNVTFTIESGTICGLLGVNGAGKSTLM
                     KILFGLVPKSDGEIQFDGLSKNKQSLGALIETPAIYHNLSAYDNLKTKALLYDIPDSKI
                     FETLEIIGLSNTGKKQAGKFSLGMKQRLGIGMAILTDPQFLILDEPTNGLDPDGINELL
                     NLIRSLKVTGMTILISSHQLLEISKIADHILILHQGKIQYDGKNKNVDSLESLFFKIVH
                     RGY"
     CDS             1944..2672
                     /locus_tag="ctg14_3"
                     /transl_table=11
                     /translation="MQKIFYSELLKLRHLGSNRFLIIIPFLTVLIAFLMGGLQIFVPFS
                     VYWWEAIFLYLVNGLLFIVDRRLEDQAGYFQNITNKHFTWKITLMKMVLIGMRTLISSL
                     FLLAFLYLVAFIYTDIIPINITKTSTSLILIWMTTLWNIPFLYLMSKYMSHFILLALNT
                     LVCLLIAPFIAQSPLWFVLPYTYHYKIAQFLLNLKPSGDVITNQNQTSILQVSLIIILS
                     MIMTLLLSYVLKRRESNATE"
     CDS             2659..3303
                     /locus_tag="ctg14_4"
                     /transl_table=11
                     /translation="MLRSELLKLKNTTCLYLIISFSILQTLSIPLYVRFVPNGISLTNL
                     AILSFLCYPLLTAFLSILGIEQEKLANHYQEISSYPKKRLLWLVKLLITDLVLTLPSLF
                     GWLIINLLLKNWINGLLLMISSWMLIVFLNHFHYFIQVCLNSTSNIVISMVEIIFIIFA
                     SNKVFLTIHWLPITFPINSVLTTEWTPLNTLPYWLVGITLLFIYFVNFKYK"
     CDS             3610..4605
                     /locus_tag="ctg14_5"
                     /transl_table=11
                     /translation="MRQLTEICDFSFIYDELEKNFRPDFGRKTYSSIMMFKYLLLKDIY
                     KLSDVESFSNMAFKYFLGLSLEDSIIEPSSLTKFRKLRIKDERLLDLLITKSVQSALEH
                     SLIKSKILIMDATILKLTTIIRNPKRFSVNTQKSCVKQFTNAQKISKKFPSKPQEDNFE
                     DELRYIQELVSVLEKHKELITLLAVSQKLNYLKEAMEDDLEHLVSSVKEEDRLDHKSAN
                     SSFYGYKEHLAMTDERVITACVVTSSEKSDSPVLEELYHKSKDNGVSKEAILGDKAYSG
                     KDNIQFTKKECVHLVAKLHPAVSRGFRRKEDEFFYNKDAGLFVCPDTKES"
     CDS             complement(5373..6710)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 110.6; E-value: 1.8e-33)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg14_6"
                     /transl_table=11
                     /translation="MFKRYSIRQRIWQFIVEIITGSLLVITLTMGMGVLLKQTGQLTLP
                     SSSSFSVDLGDVSISAINQKMRHIPYDYVIFDKKSGNILGGTYQKSDLLAYKLANNNSG
                     DVEKKGVTYTYASNEAVSIVVRHSTLPEFTNARLRHISYNKFSYVTVIVGIFLIIVVSV
                     YRLAREYQANFKEIQKLALNMGKSTLDFNNHLKILEFNDILNNLTEKNNELVYLINKER
                     HEKEDLSFQVGALSHDVRTPLTVLKGNIELLETTIISKEQSEFLEAMKRSLLRFDNYFS
                     QMMDYTKLLNEDDHKEYISLELFLSDTCLLLKEFANTYGVSYHEDIQVHNLDIYINSHA
                     LSRAITNIFVNACQYARKGSKQVYLNVYLKQDRLCFSIWNNGEPFSEGAKENASKLFYT
                     EDSGRTGKHYGIGLAFAKEVAFRHDGILELRNPPGGGAEVILQIKV"
     CDS             complement(6703..7389)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 157.2; E-value: 8e-48)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg14_7"
                     /transl_table=11
                     /translation="MHKILIVDDDIDILKMMESALRLKNYKVETRSEINVPVRTQEFQG
                     FDVILLDIMMSNIEGTDICKCIRDSISTPIIFVSAKNDERDILTGFDVGGDDYITKPFS
                     LKQLVAKVEANIKREERRRGIHQTFTDVRRDFGPLTFYLEENRVCIDGKTIPFTSREYD
                     ILELLSSHPRKVFTIDDIYTRVYDEDADALLRSISEYIYQIRKKLSCYGVEPIKTVRGK
                     GYQWNV"
     CDS             complement(7382..8980)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 227.6; E-value: 5.8e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_8"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.1e-43, bitscore:
                     139.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIIVLLFLVTCIGTVGVSYADTEDEPGGPIVSTKVFTDGELQN
                     KRENSSENKNINSDSNRLNDTSNQTGLRDDLSTDSDNADSTLINEESHSFWNYQWDMQY
                     VTDNGKSYEQYTPSKDISVGVIDSGITLDHPDLTNSLGSHLENFVPQNGFDGEEQEETG
                     VLNYVNDKLGHGTEVVGQITANGRVLGVSPGIIVNIYRVFGDSLADPKWINRAIRKAAD
                     DGNKVISLSMGQYLLISGSYDDGTNDLETYVIYKDAIDYASEKGSIVVASLGNEGLNEQ
                     DNSQMLHYLSSFHHVKEAGIVVDAPCIFDQVVAVGGLDMYGNISDFSNFTDKAIYAPAG
                     STINLKKYGPIEFLNKGFYLKDWIFTTSSTGWYQYVYGNSFAAPKVASAIALIADKYHI
                     TSPEQLKQFLFKNSPTINGNKVLKLTDLLNVGNADMFLYMSIENSISNFNIYSKSSIDH
                     SKITLQLKDVPKQLSYIITDTSIDHLNNKMLPPMGEKVGSDILLIGFLMIDLSALLICN
                     NLIIKYNSDKEVESA"
     CDS             complement(8982..9713)
                     /locus_tag="ctg14_9"
                     /transl_table=11
                     /translation="MGRRTSIIVSILLVLLTGCGLNNTEKIEFSKTDFRHITFNHKDYS
                     ITDNEISKDNIRNVLVKDYKVIWINSHTGKILSKVSNNSCTLAIMNIFQTSDKLLCIGI
                     DDKYFQIAPKDQTSNLLNISRFSSKNTNIELDSGDDILIDDNNCRRIFYRGEAYYITSE
                     EVSSDKVGVYIDNLAEVRLFDAETGKKISNEERYAIYNKGEAKDRVNWFYGEVYSIKNS
                     KDDESLVVKINNVYRRAMKEE"
     CDS             complement(9726..10946)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     279.2; E-value: 8.7e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_10"
                     /sec_met_domain="LANC_like (E-value: 2.2e-63, bitscore:
                     203.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTELKQQAIEKIIEKWDRKLIENRNEMDFTELTFSSGIPGVVLL
                     LAEYGLREGFPNYSNKIETYIEYMVYKLSRYGMLTGSIYSGASGIALSILHLQEQPNYH
                     NLFNSLNDYIVYYVEEQIKSIDIDEISPLDYDIIEGLAGILNYLLLLNDSHYDEQKVKI
                     VNYLSNLANMEDKLLKFYIKSNNQMSELENNVYPTGCLNLGLAHGLSGVGCVLCYAYRK
                     GFGNNQTLIAIKNILNIYEDFELTDWQPFIWKDSLTKEEITTNKIIHQANFIRDAWCYG
                     SPGISLFYLYSGLILNDTYLKDKAEKILKASMDRLYGVDTNMLCHGYTGIIQICSLFKK
                     ILGTNSFNNYIEEFIGKEDEVIKSFGDDELEFLEGLSGCLLAFNELEDSTKLSYWKQPL
                     LLFEDFS"
     CDS             complement(10903..12741)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 165.8; E-value:
                     2.2e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_11"
                     /transl_table=11
                     /translation="MDKIESLTAKQFIRTILTIPNTLKLIFNIEKRYAIYLIILNVLTA
                     MSSLVSLIIFQELINSIYLSSSYLIFVVIIYFILQILISLLGQVESYIDGKFNFNLSYS
                     IDRKLMETINSLELSELEQSDMYNIIEKITQESTYKPYQLFNAILQVLSSVVTMISSLI
                     FIATWNISMAMLLGVIPIISLVMFLRIGQLEFLVQWERANEERETWYIRYLLTHDFSFK
                     EIKINDLSSYFIEKFSKFKQSFIKQDLKIARKKAYFNIILGIILNTINLFIALSIIIYV
                     RAGKLLIGNFVSLIQVVARVNSSSQSLIQNIYIVYNTSLFIEQLFEFMETNNVKKENKQ
                     ANITHLNKLDEINIHQLNYRYPNTEDYALKDINLSFTRGELVAIVGGNGSGKSTLVKLI
                     SGLYTPSSGVIEYDGMSGKFLDDTFYKENISVLFQDYVKYELSLRENIGLSDTNSMRKD
                     HEIIQLLEKLGLDFLKVNGSYDLDLQLGTWFRNGRQLSGGQWQKIALARTFFKKSSIYI
                     LDEPSSALDSISQKEIFDHFIELSKNDISIFVSHDLEAAKIADRIIVMRKGKVEDIGTH
                     SELFSRCKYYKELYKSQQYEEINEYGIKTTGYREDY"
     CDS             complement(12751..15705)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     737.9; E-value: 2.7e-223)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_12"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.3e-92, bitscore:
                     300.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-10,
                     bitscore: 31.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.3e-21, bitscore:
                     65.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINSFEARDFLVRNTYCSYKNEEFISYQQLVENCLLDQVFLEQLA
                     LANPKLFETLKRYSFGNLKKKREKSLFSSIFKYYKRSFQRSTPFGLFSETSIGKFAEEG
                     QSSLSSNTIKCVSLDSQWLIELVYKLENEFYESLSFSINGSNFESGDRIFQLYTVNNTD
                     LEEINIKLTNVYKIIEEACRDKFCSYSVILDKILKEYGLEYRSLAEQYILGLIKNHYLL
                     SNLQKDLVSRFNQENFIRILQNIDYEDKYTSSFKQIVSLINEYKTLKIGKGTNLLLDIY
                     QKMSSLVENENYLQVDLLSDSKVKLNVQHKKELERFANFIGNTQKSVRRSYLDDYRDKF
                     IEKYGVDQEVPLLELLDPTFGIGAPYGYVHPKSNFYENEPLTEFYSTQEQSKYLSEYIH
                     SIRENVDIDLEKFEDYYQLEENNKFNLQGLELFFNIVENNGKPAFSLSNIVGGSDIGSA
                     SGRFSILSDELRKYQKSLLDFIEEEDSTKKITSCEIEFIPENLRHRNIMRTMNVRDKTL
                     SLFTNNSKKQIHLKDIYIGINNEEKFYAKDIINNDIVKFHVTNMYNKMLFCNEIRLLYE
                     ISLDIDSINLPWELIYSNFDYVPRIMFGDIIVAPARWKICEGDIEKLSDINTFFINKRI
                     PQKFYLINGDNRILLSRKDKLDVEFIKNELIKKLKKDSIVELQEYIQDFGIFTKEVTDR
                     VADVVIPFVNNVKKDIGITAHAKRIDIESREKLPFDEWLYLKLYIGDNRQNEFIKEYLP
                     NIQEVVDSYQGELFYLRYADPNSHIRLRMKCDNLFDLYKQILNIISEGRKNRLISSVDI
                     STYDREIERYGGEDLLLEAEKIFCTDSRLMPRLLKICETNEMGFNLDSLSIVSVYLYLV
                     FFFDNDLHEIISFLETVSPKRNDKNKDINSDVKEYQKIIEANCNEKFFLCLKNPIKSLN
                     NKMLLNKLTKQQHYSIIDSIIHVHNNRLIGIDREKEKYIYFVLRRIFISKTHIK"
     CDS             complement(15817..15978)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_13"
                     /sec_met_domain="TIGR03731 (E-value: 7.2e-15, bitscore:
                     44.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKDFNLDLVEVSKSNNGASTRITSHSFCSQACKTYKILGCNLL
                     THGCRFPR"
     CDS_motif       complement(15910..15978)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MATKDFNLDLVEVSKSNNGASTR"
                     /locus_tag="ctg14_13_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15817..15909)
                     /prepeptide="core"
                     /locus_tag="ctg14_13_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="21.80"
                     /molecular_weight="3277.8"
                     /monoisotopic_mass="3275.7"
                     /core_sequence="ITSHSFCSQACKTYKILGCNLLTHGCRFPR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MATKDFNLDLVEVSKSNNGASTR"
                     /leader_location="[15909:15978](-)"
                     /alternative_weights="3295.9"
                     /alternative_weights="3313.9"
ORIGIN
        1 ctgtatttag tacgcctttt ccaactaatc gacctaagat cgttttgata gtggattgtg
       61 tccagtccat tttttcttgc aatacggaaa tgactttttt actagttact cgatcatttg
      121 cccaaactac acgcatgact tcccattctg catctgtgat ataagtatta aattctattg
      181 tgctcattct ccttccntcc tanttgtcta cagatgtaaa cnnatatgtt taaaataagt
      241 ttacnattgt aaacgaatta tgtcaagtct ttttattaaa ttctcacttt ttggggtcag
      301 tcccttaaaa catgctattt ttatcattga taaatattaa tagctaactt tccgataaac
      361 aactattttt tatacaaaaa agacatccaa gagaaaattc ttgaatgtct gtaaacgttg
      421 atagtatcgt attgattaac gttttgagaa ttgtgatgct ttacgagctt tcttcaagcc
      481 tggtttgaca gggttaaatt tcatatagtt ttagaatagc catatattaa catctaaccg
      541 ttttatacta cttctttaat tcaaaaaatt ttaataggta ttactagatg agggaaattc
      601 caacaaatat ttgtttacat agtttagtat ctctaccact ttataatagt tccaattcaa
      661 aaattaattt caaaccatat caaaagtaga gtttctctga aattttctca atatgaacag
      721 tagtcactaa tatctattct gttaatttaa cattctaact aaagatacaa atttagtaaa
      781 aatatatgtt atcacatatt cacgctctgg gcatcttcac cagaaatatt caaccagtat
      841 tattcaattt ctaaatataa ctttccaaat acataatcgt agctcatgtc aaagattgta
      901 aaacgatttt taatagataa tccatttaaa ctccccatct tcaataaaaa gattaatgtg
      961 ctttattttg gtactgtaat gacctaacac agtatttttc aagactgata caatatttct
     1021 acctgtaata ttgaattgat cctataatat tggaaaaatt tatgctacca agttagtacc
     1081 atagaaattt tataaatact gctaactttt gagtaattca atataagttc cttaataatt
     1141 cactaaatag tcaatctagc tatgaagatg cagtcaattc ttccatttaa acagttattt
     1201 ctgacataac tctgaaaatc agatcttata atgaatgtaa caataactga taggaggcat
     1261 tcacatgcaa ataaatatca atcaactttc aaaatcctat aaagataaaa ctatattgga
     1321 caatgtcact tttaccattg aatcgggtac aatttgtggt ctattagggg ttaatggtgc
     1381 tggtaagtca actctgatga aaattctctt tggtttggtt ccaaaaagtg atggagagat
     1441 tcaatttgat ggattatcaa aaaacaaaca atcattaggc gcattaattg aaacacctgc
     1501 tatttatcat aacctttcag cctatgacaa tttaaaaacg aaagcgctat tatatgacat
     1561 tcctgattca aaaatttttg aaaccttaga aataattggt ctttctaaca ccgggaaaaa
     1621 acaagcgggt aaattttcat tagggatgaa gcagagacta ggaattggca tggctatttt
     1681 aactgatccc caatttttaa ttctcgatga gcctactaat ggacttgatc ctgatggtat
     1741 aaacgaactg ttaaacctta ttcgttcatt aaaagtaaca gggatgacaa ttctgatttc
     1801 tagccatcaa cttttagaaa tcagcaaaat tgccgatcac attctaattc tacatcaagg
     1861 aaagatacaa tatgacggta agaataagaa tgtagatagt ctggaaagtt tattctttaa
     1921 aatcgttcat agggggtact gatatgcaaa agatattcta ctcagaattg ctcaaattac
     1981 gacatttagg atccaataga ttcttaatta tcataccgtt tttaactgtc ctaatagcct
     2041 ttttaatggg aggactacag atttttgttc ctttttcagt ctattggtgg gaagctatct
     2101 ttttatatct cgtaaatggt cttttattca tagttgatag acgtttggaa gatcaggcag
     2161 ggtattttca aaatattact aacaagcatt tcacttggaa aattaccttg atgaaaatgg
     2221 tgcttatcgg aatgagaaca ttgatttcta gtttattctt actagctttc ctgtatctcg
     2281 ttgcttttat ttacacagat attatcccaa taaacattac taaaacatct acttcattaa
     2341 tcttaatttg gatgacaact ttatggaata ttccttttct gtatctgatg tctaaataca
     2401 tgagtcattt cattctatta gcgcttaata cactggtttg tcttttaata gcaccattta
     2461 ttgctcaaag tccactctgg ttcgtcttgc cctataccta tcactataaa atagctcaat
     2521 ttttattaaa ccttaaacca tcgggcgacg ttattacaaa tcaaaaccaa accagcattt
     2581 tgcaagtgtc acttattatt attttatcaa tgataatgac attactttta tcatatgtcc
     2641 taaaaaggag ggagtcaaat gctacggagt gagttactta aattaaagaa tactacatgt
     2701 ctctatctta ttatcagttt ttctatacta caaactcttt caattcccct ctatgtaaga
     2761 ttcgtcccta atggcatttc tctaactaat ctagctatct tatccttttt atgttatcct
     2821 ctattgacag ctttcttatc cattttagga attgaacaag aaaaactcgc taatcattat
     2881 caagaaatct ctagttaccc taagaaaaga ctcctgtggc tagtcaaact tttaataaca
     2941 gacttagtcc ttaccctgcc ttctttattt gggtggttaa tcataaacct cctccttaag
     3001 aattggatta atggtctcct gctaatgata tcaagttgga tgctaattgt ctttcttaat
     3061 cattttcatt attttataca agtttgtcta aatagtacga gtaacatcgt tatttctatg
     3121 gttgaaatca tttttattat tttcgctagt aataaagtct tcttaactat tcattggctt
     3181 cctattactt ttcctattaa cagtgttctc actacagagt ggactccact caacactctt
     3241 ccttattggc ttgtaggaat cacgctatta tttatctatt ttgtaaactt taaatacaaa
     3301 taatacatca aagatgcact agaaacagac tattcaaacg cgaaactcga agcaactaat
     3361 aagttgatca aagacatcaa acgcctgggc ttcggtttta gaaacttcat cagctttaag
     3421 aagcgtgtat tcatgactct gaacataaaa aaagagaaga cctagccggg agcccactga
     3481 aaaagtcatc aatcgatggc ttttttgtta tactaaactc gaggtgattg tatacttgat
     3541 aatcagttaa ctttagaagt tagtccctat tccagtctat atgatattgt tgttccaaag
     3601 aatcattttt tgcgtcagct aacggaaatc tgtgatttta gctttattta cgatgagtta
     3661 gaaaagaatt ttcgtcctga ctttggacgt aaaacttatt cgtcgattat gatgttcaaa
     3721 tatctcttat taaaagacat ctataagtta tccgatgtgg agtccttttc taatatggct
     3781 tttaaatact tccttggtct atctctagag gatagcatta ttgaaccctc ttcattgact
     3841 aaatttcgca aacttcgaat caaagatgaa cgattacttg atttactcat cactaaatct
     3901 gtacaaagcg ctcttgagca tagcttgatt aaaagtaaaa ttctcattat ggatgcgacc
     3961 atactaaagc tcactacaat cataagaaac cccaagaggt tctccgtgaa cactcaaaag
     4021 tcttgcgtaa aacaatttac caatgctcag aagatatcaa agaagtttcc tagcaagcct
     4081 caagaagata attttgaaga tgaattaaga tatatacaag agttggtatc agtcctagaa
     4141 aaacataaag aattgataac tttacttgcg gtttcgcaaa aattaaatta ccttaaagaa
     4201 gctatggagg atgatttaga acacttggta tcctctgtta aagaagaaga tcgtcttgac
     4261 cataaatctg cgaatagttc cttttatggc tataaagagc atctcgccat gacagatgaa
     4321 cgtgtgatca cagcctgtgt cgtgacatcc agtgaaaaaa gtgatagtcc tgtcttagaa
     4381 gaactctatc ataaatctaa ggataatggt gtaagcaaag aagctattct aggggataag
     4441 gcctattctg ggaaagataa tattcaattt accaaaaaag aatgtgtgca tttagtcgct
     4501 aagctacatc ctgctgtttc aagaggcttt cgtcggaaag aagatgaatt cttctataac
     4561 aaggatgcag gtctctttgt ttgtccagat actaaagaaa gctaagatag gaagaacaac
     4621 ggggaaatat aattctcagg aaacccactg ttttgatatt aagtattgtc aaatctgccc
     4681 ttcaaaatgc ggaacttaaa cacaaacata gtcttgatat ggctagagca tcaggtcttt
     4741 tcaatatggt gttacaagcg acaacaacta tattcggggt caatatgaag aggattataa
     4801 ctttaataaa ttcaaaataa gtaaacaaaa ggagaaatct atctcatatt taggtagatt
     4861 actccttttt attttattta aactgtagag attacttttt cagtgggctc cctatccggt
     4921 cttctctaga tgttagcttt tcgttaccca ctacagttga cagagagcca caatagcttc
     4981 aaccaagcca catgcgattg tctctataca tcgtctcatt cggacaatgt attacctcat
     5041 tactattacc tcattacgca taacaaactt tacgattact cttccgccca taatcgatat
     5101 agttgtctat gctgtattac tgtaacacct tgtttaaaaa tacctagatg aggtgttatt
     5161 ttgcatgccc ttttatagct aaataagtgt taaaaataag acagcgactt cagaaaagct
     5221 actgtcatat ttcatgatag acttgacaaa tggtagaaaa gagccactta aattatttgt
     5281 ctaatttttt tggagtcagc agatacttga gagcactttt atctaaaata tctcttttgg
     5341 gtagtttatc atttgcttca acctttctcg tatcatactt taatttgtaa aatcacttct
     5401 gctccacccc ctgggggatt tctcaactct aaaattccat catgtctgaa agctacttct
     5461 ttagcaaaag ctaagcctat cccataatgt ttaccagtcc ttccagaatc ctctgtataa
     5521 aatagcttac tcgcattttc ttttgcacct tcagaaaatg gttccccatt attccatatt
     5581 gaaaagcata acctatcttg tttcaaatat acgtttaaat aaacctgttt actacctttt
     5641 ctagcatatt ggcatgcatt tacaaaaata ttagttatcg ctcttgacaa agcatgacta
     5701 ttgatataaa tatctaagtt atggacttga atatcttcat gataggaaac accatacgta
     5761 ttagcaaact cctttaataa taagcatgta tctgataaaa ataattctaa cgaaatatac
     5821 tccttatgat catcttcatt taataattta gtataatcca tcatttgaga aaaataatta
     5881 tcaaatcgta acaatgaacg cttcatagct tctaaaaact cactttgttc cttagaaata
     5941 atcgtcgttt ccaaaagctc tatattaccc ttcagaacag tcaagggtgt tcttacatca
     6001 tgtgaaagcg ctcctacttg aaatgataaa tcttcttttt catgtctctc tttatttatt
     6061 aaatatacta attcgttatt tttttctgtt agattgttca aaatatcgtt aaattctaat
     6121 atttttaaat ggttgttaaa atctagagtt gattttccca tatttaatgc tagtttttga
     6181 atttctttaa aattagcctg atattcccta gctaaacgat ataccgaaac aacaattatt
     6241 aagaaaattc caacaattac agttacatag gaaaacttgt tataactaat atggcgtagt
     6301 ctagcattgg taaattctgg aagagtgcta tgtcttacaa ctatagatac tgcctcgtta
     6361 cttgcatagg tataagtaac cccctttttt tcaacatctc cactattgtt atttgcaagt
     6421 ttatatgcta gtaaatcact tttttgatag gttccaccca aaatattacc tgatttttta
     6481 tcaaagatta catagtcata aggaatgtgc ctcatttttt ggttaattgc tgatatagag
     6541 acatcaccca aatcaaccga gaaactcgaa gaagatggta aggtcagttg tcccgtttgt
     6601 ttcaacaata ctcccatacc catggtaaga gtaatcacaa gaagagaacc agttatgatt
     6661 tcaacaataa attgccaaat acgttggcgt atagagtatc gtttaaacat tccactggta
     6721 ccccttacct ctaacggttt ttataggttc tacaccataa catgatagtt tttttcttat
     6781 ttgataaata tattccgaaa tagaacgaag aagtgcatcc gcatcctcat cataaacacg
     6841 tgtataaata tcatcaattg taaatacttt tctaggatgg cttgataaaa gttccaaaat
     6901 atcgtattcc ctactagtaa agggaatcgt tttaccatca atgcaaacac gattctcttc
     6961 gagatagaag gttaaaggtc caaagtcacg tctaacatca gtaaaggttt ggtgtatccc
     7021 cctacgacgc tcctcacgct taatatttgc ttctactttg gcaactagct gttttaaact
     7081 aaagggttta gtaatgtagt catcaccacc tacgtcgaat ccagttaaaa tatctctttc
     7141 atcattttta gcactaacaa aaattattgg agttgaaata gaatctctga tacatttaca
     7201 gatatctgtc ccttcaatgt tcgacatcat aatatctaat aatataacat caaatccttg
     7261 aaattcttga gttcgtactg gaacattaat ttctgatcgc gtctccacct tatagttttt
     7321 taatcgaaga gctgattcca tcatttttaa aatatcaata tcatcatcta caataagaat
     7381 tttatgcact ttctacctcc ttatcactat tatactttat aattaaatta ttacaaatta
     7441 ataatgcaga caaatcaatc atcaaaaaac caattagcaa tatatcagag cctaccttct
     7501 cacccatcgg aggcaacatt ttattattca gatgatcaat actagtatcg gtaataatat
     7561 aagaaagttg tttcgggaca tcctttaatt gaagtgttat ctttgaatga tcaatactcg
     7621 acttagaata tatattaaag tttgatatac tattttctat actcatatag agaaacatat
     7681 ctgcatttcc cacattcaaa agatcagtta attttagtac cttatttccg ttaatagtcg
     7741 gtgagttttt aaaaagaaat tgtttcaatt gttctggtga cgtaatatga tacttatctg
     7801 ctattaatgc tatagctgaa gcaactttcg gagcagcaaa agaatttcca tacacatact
     7861 gataccaccc tgtagaacta gttgtaaaaa tccaatcttt taaatagaaa cctttattta
     7921 aaaattctat aggaccatac tttttaagat taattgttga acccgcagga gcatagattg
     7981 ctttatcagt gaagttacta aagtctgaaa tattcccata catatcgagt cctccgaccg
     8041 caacaacctg gtcgaatatg caaggcgcat ccactactat ccctgcttct tttacatgat
     8101 gaaaactgct aagataatgc aacatttgtg aattatcttg ttcatttaaa ccctcattcc
     8161 ctagagaagc aactacaatg gatcctttct cacttgcata atcaatggca tctttatata
     8221 taacataagt ctccaaatca ttcgttccat catcataaga acctgaaatt aataaatatt
     8281 gtcccatact aagtgaaata actttattac catcatcagc tgcttttctt attgccctat
     8341 taatccattt aggatcagca agtgaatctc caaagacacg ataaatattt acaatgatac
     8401 ctggggagac tcccaaaact cgtccattcg ctgttatctg ccctacaact tcggtaccat
     8461 gtcccaattt atcattgaca taatttagca cccctgtttc ttcttgttct tcaccatcaa
     8521 aaccattttg gggaacaaaa ttttctaaat ggctacctaa actattagtt aaatccggat
     8581 gatccaaagt aatacctgaa tcgattactc caacagaaat atccttagaa ggagtgtatt
     8641 gttcatagct tttaccatta tcggtaacat actgcatgtc ccactgataa ttccaaaaac
     8701 tatgactctc ttcatttatc agtgtactat cagcattatc actatcagtt gacaagtcat
     8761 cccttaagcc agtttgatta ctagtatcat ttaatcgatt tgaatctgaa ttgatattct
     8821 tattttctga agagttttcc ctcttgtttt gtaattctcc atctgtaaat acttttgtag
     8881 aaactatcgg accacctggt tcatcttcgg tatctgcata gcttactcct actgtcccaa
     8941 tacaagttac caaaaacaat aaaactatga ttcttttcat cctactcttc cttcattgca
     9001 cgcctgtaaa cattattaat cttaaccaca agggactcat catcttttga attctttatg
     9061 gaatatactt ctccataaaa ccaattcact cgatctttag cttctccctt attataaatt
     9121 gcataacgct cctcattcga aattttcttt ccagtctcag catcaaagag tcttacctct
     9181 gccaaattgt caatataaac tcctacctta tcactcgata cttcttcact tgttatgtaa
     9241 taagcttctc ctcggtagaa tattctccta caattattat catcgattaa aatatcgtct
     9301 ccactgtcca attcaatatt tgtgtttttg ctactgaatc tagatatatt taacagatta
     9361 gatgtttgat ctttcggagc aatttgaaaa tacttatcat caataccaat acacagtagt
     9421 ttatcacttg tttgaaatat attcattatt gccagtgtac aactgttatt tgatactttt
     9481 gagagaattt ttcctgtatg agagttaatc caaatcactt tatagtcttt taccaaaaca
     9541 ttccttatat tatctttaga aatttcatta tcagtgattg aataatcttt gtgattaaac
     9601 gttatatgtc taaaatctgt tttagaaaac tctattttct ccgtattatt tagtccacat
     9661 cctgtcaaca atacaagtaa aatagacact ataatgcttg ttcgtcgtcc catttatatt
     9721 cctttctagc taaaatcttc aaaaagtagt aatggttgtt tccaatatga caattttgtc
     9781 gaatcttcaa gttcattaaa agcaagtaaa catccactca gtccttcaag aaactctaat
     9841 tcatcgtctc caaaactctt tattacttca tcctctttcc caataaactc ttcaatatag
     9901 ttattaaaag aattcgttcc aagaattttt ttaaataatg aacagatttg aattattcca
     9961 gtataaccat gacaaagcat atttgtgtct acaccatata atctatccat agatgccttt
    10021 aatatttttt ccgccttgtc ttttaagtag gtatcattta aaattaatcc actatataag
    10081 taaaataagc ttatacctgg actaccataa caccacgcat ctcttataaa gtttgcctga
    10141 tggataatct tattagtagt aatctcttcc ttagttaaag aatctttcca aataaacggt
    10201 tgccaatccg tcaattcaaa atcttcatat atattgagaa tattcttaat tgctattaaa
    10261 gtctgattat tcccaaatcc cttcctatac gcatagcata aaacgcaacc aacaccagaa
    10321 aggccgtgag ctagtcctaa gttaaggcat cccgttggat atacattatt ctccaattca
    10381 gacatttgat tatttgattt gatataaaat tttaatagct tatcttccat attagctaag
    10441 tttgataagt aatttacaat ctttactttc tgctcatcat agtgagaatc gtttaggaga
    10501 agtaaatagt tcagtattcc tgccaatccc tcaataatat cataatctag aggtgagatt
    10561 tcatcaatat caatagattt aatttgctcc tcaacataat atactatata gtcattaaga
    10621 ctattaaaaa gattatgata attaggttgc tcttgtaaat gaagaatact taatgctatt
    10681 ccgctagctc cggaataaat tgaaccagtc aacataccat atctggataa tttataaacc
    10741 atatactcga tgtaagtttc tattttattg ctataatttg gaaacccctc tcggagacca
    10801 tactccgcta gtaagagaac aactcctggt ataccacttg aaaatgttag ctccgtgaag
    10861 tccatttcat ttctattttc gataagttta cgatcccact tttcaataat cttctctata
    10921 gcctgttgtt ttaattccgt attcatttat ttcctcatac tgctgtgatt tatatagttc
    10981 tttataatac ttacatcgtg aaaataattc actgtgtgtt ccaatgtcct caacttttcc
    11041 ttttctcata acaataattc tatctgctat tttagctgct tctaaatcat gtgatacaaa
    11101 aatagagata tcattttttg acaactcaat gaaatgatca aaaatttctt tttgagatat
    11161 tgaatcaagg gccgaacttg gttcatctaa aatatagatg gatgattttt taaagaaagt
    11221 tcttgctaga gcaatttttt gccactgccc tcctgacagt tgtctaccat ttctaaacca
    11281 tgtacctaat tgtaaatcaa gatcatagct accattaact ttaagaaaat ctagtcccaa
    11341 tttttctaat aattgaataa tttcgtggtc ctttctcatc gaattagtat cactcagtcc
    11401 tatattctct cttaatgata actcatactt aacataatct tgaaaaagca ctgatatatt
    11461 ctctttatag aatgtatcat ccaaaaattt tccggacata ccatcatatt ctattacacc
    11521 acttgatggt gtatataatc ctgaaattaa tttaaccagt gtactcttac ctgagccatt
    11581 tccaccaaca atagctacta attcacccct tgtaaaggat aaattgatgt cttttaaagc
    11641 ataatcttct gtatttgggt atctgtagtt aagttgatga atattaattt catctaactt
    11701 atttagatgc gtaatattag cttgtttgtt ctctttcttt acattattag tctccataaa
    11761 ttcaaataat tgctcgataa ataaacttgt attatacact atatagatat tttgaattaa
    11821 tgactgtgag gaactattca ctcgtgcaac aacctgtatt aaactaacaa aattacctat
    11881 aagaagtttt cctgctctta cataaataat aattgataaa gcaataaata aattaattgt
    11941 atttaatatg atacctaaga ttatattaaa atatgctttt tttctagcaa tcttaagatc
    12001 ctgcttgata aagctttgtt taaattttga aaatttctca ataaaataac tacttaaatc
    12061 atttatctta atctctttaa atgaaaaatc atgagtaagt agatatctta tgtaccatgt
    12121 ctcccgttct tcattagctc tctcccattg aaccaaaaat tctaattgac caatcctcaa
    12181 aaacattact aaagaaataa taggaataac tcctaataac atagccatac tgatattcca
    12241 tgttgcaatg aatatcaagc tagatatcat cgtaactact gatgatagca cctgtaagat
    12301 tgcattaaat aattgatatg gtttataggt gctttcttga gttattttct caataatgtt
    12361 atacatatca gactgctcaa gttcacttaa ctcaagggag ttaatcgttt ccattaattt
    12421 tctatcaata ctataggaca gattgaaatt aaatttccca tcaatataac tctcaacttg
    12481 acccaacaat gagataagta tttgcaaaat aaaataaata attactacaa aaattaaata
    12541 acttgatgat aaataaatag aattaatcaa ttcttgaaaa ataataagac taaccaatga
    12601 agacatcgct gtcaaaacat ttaaaataat taaataaatc gcatatcttt tttcaatatt
    12661 gaaaatcaat ttcaatgtat ttggaatagt aagtatagtc ctaataaact gttttgcagt
    12721 caggctctcg attttgtcca ttatatactc ctacttaata tgtgttttac taatgaatat
    12781 gcgtcgaaga acaaaataaa tatatttttc tttttctcta tcaatcccaa ttaaacgatt
    12841 attatgaaca tgaataatac tatcaattat cgaataatgt tgttgctttg taagtttatt
    12901 tagtaacatt ttattgttta agctttttat tggatttttt aagcatagaa agaatttttc
    12961 attacaatta gcttcaataa ttttctgata ctccttaaca tcactattta tatctttatt
    13021 tttatcattt ctcttaggac tcactgtctc taagaaagaa ataatctcat gaaggtcatt
    13081 atcaaagaag aatacaagat acaaataaac acttacaatg gacagactgt ctaagttaaa
    13141 ccccatttca tttgtttcac aaatcttcaa taatcgtggc atcaatcttg aatcagtaca
    13201 aaaaattttt tcggcttcca acagcagatc ctcgccacca tatctctcaa tctcacgatc
    13261 atatgtagaa atatctacac tcgaaatcaa acgattcttt cttccttcag agataatatt
    13321 taaaatttgt ttatacaaat caaataaatt atcacacttc atgcgtagtc gaatatgtga
    13381 attgggatca gcatacctaa gataaaacaa ttctccttga tagctatcaa ctacctcttg
    13441 aatattaggt agatattctt taataaactc attttgccta ttatctccaa tatataattt
    13501 caaatataac cattcatcaa aaggtaattt ttctcgtgat tctatatcta ttctcttagc
    13561 atgtgcagtt ataccaatat cttttttcac attattaaca aacggaatta ctacgtcagc
    13621 tactctgtca gtcacttcct ttgtaaaaat tccaaaatcc tgaatatatt cttgtaattc
    13681 tacgatacta tcttttttta atttttttat tagctcattt ttaataaatt caacgtctaa
    13741 tttgtcttta cgtgaaagta aaatcctatt atctccattg ataagataaa atttctgagg
    13801 gattcgctta tttatgaaaa aggtattaat atcagaaagt ttctcgatat ctccttcaca
    13861 aattttccat ctagcaggag caactataat atcaccaaac ataattctag gtacataatc
    13921 gaaattgcta tatattaatt cccatggtaa attgatagaa tcaatatcta aagaaatttc
    13981 atacaacaaa cgaatttcat tacaaaataa cattttatta tacatattcg taacatgaaa
    14041 ctttacaata tcattattta ttatatcttt ggcgtaaaat ttttcttcat tatttatacc
    14101 aatataaata tctttcaaat gaatttgttt cttactatta ttagtaaata aagaaagagt
    14161 tttatctctt acattcattg ttctcatgat attccgatgt cttaaatttt caggaataaa
    14221 ttcaatctca caggacgtaa ttttcttagt tgaatcctct tcttcaataa aatctaataa
    14281 tgatttttga tatttcctaa gttcatctga taaaattgaa aaacgtcctg atgcactacc
    14341 aatatcactt ccaccaacaa tattacttaa tgagaaagct ggttttccat tattttcgac
    14401 aatattaaaa aataattcca aaccttgcaa attaaactta ttattctctt ctagttgata
    14461 ataatcctca aatttttcta agtctatatc tacattttct ctaattgaat ggatatattc
    14521 actcagatat ttactttgct cctgagtact ataaaactct gtaagcggtt cattctcgta
    14581 gaaattgctt tttggatgga cataaccata cggagcaccg attccaaacg taggatctaa
    14641 taattctaat aacggaacct cttgatcaac tccatatttc tcgataaact tatctctata
    14701 atcatccaaa tagctgcgtc taactgactt ttgtgtattt cctataaagt tagcaaaacg
    14761 ttcaagttcc ttcttatgtt gaacgtttag tttaacctta gaatcactta acaaatcaac
    14821 ttgaagataa ttttcatttt caactagact agacattttt tgataaatgt ccaacaacaa
    14881 gtttgttcct tttccgattt taagggtttt atactcatta attaaactta ctatttgttt
    14941 gaaagaagaa gtatatttat cctcatagtc aatattctga agtattctta taaaattctc
    15001 ttgattaaat ctcgaaacta agtctttctg taaattagat aataaataat ggttcttaat
    15061 tagacccaaa atatactgtt ctgccaaact gcgatactca agtccatact cttttaaaat
    15121 tttatctaag ataactgaat aactacagaa cttatctcta caagcttctt caataatttt
    15181 ataaacatta gttaatttga tattaatttc ttctaaatct gtgttattca ctgtataaag
    15241 ttgaaaaata cgatcacctg attcaaagtt cgaaccatta atactaaatg aaagtgactc
    15301 ataaaattca ttctctaatt tatagacaag ttctattagc cactgactgt caagtgaaac
    15361 acatttaata gtattagagg ataagctact ttgtccttct tcagcaaatt ttccaattga
    15421 agtttcactg aataaaccaa atggcgttga gcgttgaaaa ctcctcttat agtacttaaa
    15481 aatagacgaa aataaacttt tttctctctt cttttttaga ttgccaaaac tatatctttt
    15541 taacgtctcg aatagcttag gattagctaa ggctaactgt tctaagaaca cctgatctaa
    15601 taaacagttt tcaactaatt gttggtacga tataaattct tcatttttat atgaacaata
    15661 tgtatttcta actaaaaaat ctctagcttc aaatgaatta atcaaaataa tgactccttt
    15721 attactttta taaattatta aatacctatt tccagtaact tataaaaata ggatagtgta
    15781 aaaatgcact atccaacaaa atatttcagc gtcttcctac ctaggaaacc tacatccgtg
    15841 tgttagtaaa ttacatccta aaatcttata agtcttacaa gcttgtgagc aaaatgaatg
    15901 actagtaatt cgagttgaag ctccattatt gctttttgag acttctacca agtctaaatt
    15961 aaaatctttt gtagccattt aagcacctcc ttaataattt atcagtatag tacagaatac
    16021 ttgctaatta agtactaatc tgttaccata gtgcgtgtgt agtaacttta tattaataaa
    16081 tatttgtaag ataatataca gaattcctta tttcttgatc ttctattatt tatacacaat
    16141 gaggacttat gtttaccttt aatacttcag cgatgaaact ctcttaataa gactagaatg
    16201 ttttctaaac tattattacg ctatttactg acatggacat gaacattaca tccaatactt
    16261 tggatgtgac atcccataag tacaccagta atgcatcctg gtgtacaaag tgaatagct
//
