Genome ID：GCA_009716995.1

Potential risk score of uploaded strain

ARGs	VFs	PGs	PPRS
2	22	33	39.71

CARD

Query ID	Begin	End	ARO name	ARO accession	CARD name	Identity	Coverage	Accession no.
No hit found

Resfinder

Query ID	Begin	End	Resistance gene	Phenotype	Identity	Coverage	Accession no.
CEIGBEMD_9	303123	304340	mef(A)	Erythromycin, Azithromycin	100.00	100.00	U83667
CEIGBEMD_9	304460	305923	msr(D)	Erythromycin, Azithromycin, Telithromycin, Quinupristin, Pristinamycin IA, Virginiamycin S	100.00	100.00	AF274302

AMRFinderPlus

Query ID	Begin	End	Gene symbol	Sequence name	Method	Identity	Coverage	Accession no.
CEIGBEMD_9	303123	304337	mef(A)	macrolide efflux MFS transporter Mef(A)	EXACTX	100.00	100.00	WP_000417519.1
CEIGBEMD_9	304460	305920	msr(D)	ABC-F type ribosomal protection protein Msr(D)	EXACTX	100.00	100.00	WP_000420313.1

Virulence Factor Database (VFDB)

Query ID	qstart	qend	Gene name	e-value	VF name	VF category	Identity	Coverage	Accession no.
CEIGBEMD_15	48654	50114	STU_RS14650	0.0	Capsule	Immune modulation	96.92	100.21	WP_011226049
CEIGBEMD_15	48654	50114	STER_RS05320	0.0	Capsule	Immune modulation	96.85	100.00	WP_011681177
CEIGBEMD_15	48654	50114	STR_RS05265	0.0	Capsule	Immune modulation	96.03	100.21	WP_041827043
CEIGBEMD_10	355417	356226	STU_RS16245	0.0	Capsule	Immune modulation	95.31	100.00	WP_002948020
CEIGBEMD_15	45049	46414	STER_RS05300	0.0	Capsule	Immune modulation	95.09	99.85	WP_011681173
CEIGBEMD_10	347428	348279	rfbD	0.0	Capsule	Immune modulation	95.07	100.00	WP_014621820
CEIGBEMD_15	46471	47211	STER_RS05305	0.0	Capsule	Immune modulation	94.87	100.00	WP_011681174
CEIGBEMD_15	45047	46414	STU_RS14630	0.0	Capsule	Immune modulation	94.59	100.00	WP_011226045
CEIGBEMD_15	46471	47211	STU_RS14635	0.0	Capsule	Immune modulation	94.33	100.00	WP_011226046
CEIGBEMD_12	47421	48704	tig/ropA	0.0	Trigger factor	Stress survival	94.08	100.00	WP_011225339
CEIGBEMD_15	46476	47211	STR_RS05250	0.0	Capsule	Immune modulation	93.89	98.13	WP_011227246
CEIGBEMD_15	47922	48653	STER_RS05315	0.0	Capsule	Immune modulation	93.85	100.00	WP_011681176
CEIGBEMD_15	47922	48653	STU_RS14645	0.0	Capsule	Immune modulation	93.72	100.00	WP_011226048
CEIGBEMD_10	349380	350651	STU_RS16265	0.0	Capsule	Immune modulation	93.71	99.76	WP_011226331
CEIGBEMD_10	356226	357431	STU_RS16240	0.0	Capsule	Immune modulation	93.53	100.00	WP_011226326
CEIGBEMD_15	47922	48653	STR_RS05260	0.0	Capsule	Immune modulation	93.17	100.00	WP_011227248
CEIGBEMD_10	358482	360266	STU_RS16230	0.0	Capsule	Immune modulation	92.94	100.00	WP_011226325
CEIGBEMD_10	353332	354480	STU_RS16255	0.0	Capsule	Immune modulation	92.17	100.00	WP_041828290
CEIGBEMD_9	459270	459863	STR_RS05880	0.0	Capsule	Immune modulation	91.92	100.00	WP_011226149
CEIGBEMD_9	459270	459863	STER_RS06030	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
CEIGBEMD_9	459270	459863	STU_RS15260	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
CEIGBEMD_10	357451	358485	STU_RS16235	0.0	Capsule	Immune modulation	91.39	99.05	WP_002948022
CEIGBEMD_10	354477	355433	STU_RS16250	0.0	Capsule	Immune modulation	91.33	100.00	WP_011226328
CEIGBEMD_9	458401	459270	rfbA	0.0	Capsule	Immune modulation	91.03	100.00	WP_011681286
CEIGBEMD_12	17955	18794	cbpD	0.0	Autolysin	Exoenzyme	90.95	100.00	WP_011226733
CEIGBEMD_11	186257	187915	fbp54	0.0	FBPs	Adherence	90.36	99.94	WP_011227179
CEIGBEMD_10	14421	15431	plr/gapA	0.0	Streptococcal plasmin receptor/GAPDH	Adherence	88.65	99.80	WP_002986042
CEIGBEMD_15	47221	47913	STR_RS05255	0.0	Capsule	Immune modulation	88.47	99.86	WP_011227247
CEIGBEMD_15	47221	47913	STU_RS14640	0.0	Capsule	Immune modulation	88.47	99.86	WP_011226047
CEIGBEMD_9	277636	278939	eno	0.0	Streptococcal enolase	Exoenzyme	88.47	99.54	WP_000022832
CEIGBEMD_15	47221	47913	STER_RS05310	0.0	Capsule	Immune modulation	88.18	99.86	WP_011681175
CEIGBEMD_11	30801	31562	srtA	0.0	Sortase A	Exoenzyme	84.03	99.74	-
CEIGBEMD_9	460066	461112	rfbB	0.0	Capsule	Immune modulation	80.42	100.00	WP_009659423

VirulenceFinder

Query ID	Begin	End	Database	Virulence factor	Protein function	Identity	Coverage	Accession no.
No hit found

PHI-base

Query ID	qstart	qend	Gene name	e-value	Function	Identity	Coverage	Gene ID
CEIGBEMD_11	28111	27137	ldh(Sp_1220)	0.0	L-lactate dehydrogenase	96.92	99.09	AAK75326
CEIGBEMD_11	39692	40765	MntE	0.0	manganese homeostasis	95.25	99.72	ABF32167
CEIGBEMD_10	146417	144111	pfl2(Sp_0459)	0.0	formate acetyltransferase	94.41	99.22	AAK74619
CEIGBEMD_9	187839	188807	spr0084	0.0	pathogenitcity related	93.19	98.48	AAK98888
CEIGBEMD_14	124488	125969	SPD_0310	0.0	UPF0371 protein SPD_0310	93.12	100.00	ABJ54480
CEIGBEMD_11	67747	69993	metE	0.0	methionine biosynthesis enzymes	92.39	100.00	AAK74738
CEIGBEMD_12	3570	4541	prsA2	0.0	ribose-phosphate pyrophosphokinase	91.36	100.00	ABF36968
CEIGBEMD_10	296953	298101	potA	0.0	ABC transporter ATP-binding protein-spermidine/putrescine transport	90.08	99.48	AAL00050
CEIGBEMD_9	433016	434746	ptsI	0.0	phosphoenolpyruvate-protein phosphotransferase	89.95	100.00	AAK34199
CEIGBEMD_10	334032	336020	uvrB	0.0	excinuclease ABC, B subunit	89.59	100.00	AE014259_2
CEIGBEMD_13	163546	162068	IMPDH	0.0	inosine-5'-monophosphate dehydrogenase	87.63	100.00	ADE32434
CEIGBEMD_9	277636	278937	Eno	0.0	enolase	86.44	99.77	ABP90468
CEIGBEMD_13	148223	146331	gidA	0.0	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	85.26	98.90	ABP91129
CEIGBEMD_11	72912	71203	PGM	0.0	phosphoglucomutase	84.76	99.65	ACH87041
CEIGBEMD_12	37464	38555	recA	0.0	DNA recombination and repair	84.64	95.36	AAL00560
CEIGBEMD_13	28754	29764	pdh	0.0	pyruvate dehydrogenase	82.79	99.70	ABP91006
CEIGBEMD_11	201436	200075	mnmE	0.0	central tRNA-modifying GTPase	82.46	99.56	ABP90420
CEIGBEMD_9	263226	264116	bglB	6.70e-178	putative phospho--glucosidase	87.88	99.66	AAK33487
CEIGBEMD_11	113771	112821	SP_0676	6.61e-170	transcription facot	81.39	98.45	AAK74821
CEIGBEMD_11	70180	71037	metF	5.42e-168	methionine biosynthesis enzymes	87.06	99.31	AAK74739
CEIGBEMD_14	52373	51702	rr01	3.36e-127	response regulator	84.82	99.56	CAB54566
CEIGBEMD_3	1884	2588	covR	3.74e-127	responder protein	85.11	100.00	AAK71319
CEIGBEMD_11	76880	77551	ciaR	1.10e-124	two component system response regulator	85.71	99.12	AIK75708
CEIGBEMD_11	76880	77548	CiaR	1.37e-124	two-component response regulator	87.00	99.55	AAK74935
CEIGBEMD_3	1884	2588	walR	6.86e-121	DNA-binding response regulator	81.70	100.00	ANC99504
CEIGBEMD_12	206961	207647	CovR	5.78e-120	serves to repress GAS virulence factor-encoding genes	81.66	100.00	ACE75886
CEIGBEMD_12	38729	39124	SpxA2	2.60e-75	transcriptional regulator	91.67	100.00	ERL21461
CEIGBEMD_11	212902	213303	SpxA1	2.73e-69	transcriptional regulator	82.09	100.00	ERL19273
CEIGBEMD_16	6355	5942	GrpE	9.63e-68	protein grpE	81.16	80.59	ABP89267
CEIGBEMD_12	230740	231027	spr0479	7.00e-48	essential gene	85.42	98.97	AAK99283
CEIGBEMD_9	151437	151691	spr1327	2.45e-44	essential gene	92.94	100.00	AAL00131
CEIGBEMD_13	117226	117489	spr0175	9.79e-43	pathogenitcity related	85.23	100.00	AAK98979
CEIGBEMD_13	118052	118318	spr0177	1.36e-41	essential gene	83.15	88.12	AAK98981
CEIGBEMD_12	48871	49362	RopE (M5005_Spy_1611)	1.28e-72	probable DNA-directed RNA polymerase subunit delta	82.93	85.86	AAK34603
CEIGBEMD_10	146417	144117	PFL (B9H01_RS01125)	0.0	formate C-acetyltransferase	83.09	98.08	MYN69560
CEIGBEMD_13	65476	64457	ilvC (SPD_0406)	0.0	ketol-acid reductoisomerase (NADP(+))	96.77	100.00	ABJ55451