Genome ID：GCA_009717065.1

Potential risk score of uploaded strain

ARGs	VFs	PGs	PPRS
2	22	33	39.71

CARD

Query ID	Begin	End	ARO name	ARO accession	CARD name	Identity	Coverage	Accession no.
No hit found

Resfinder

Query ID	Begin	End	Resistance gene	Phenotype	Identity	Coverage	Accession no.
APPLDMEG_8	825	2042	mef(A)	Erythromycin, Azithromycin	100.00	100.00	U83667
APPLDMEG_8	2162	3625	msr(D)	Erythromycin, Azithromycin, Telithromycin, Quinupristin, Pristinamycin IA, Virginiamycin S	100.00	100.00	AF274302

AMRFinderPlus

Query ID	Begin	End	Gene symbol	Sequence name	Method	Identity	Coverage	Accession no.
APPLDMEG_8	825	2039	mef(A)	macrolide efflux MFS transporter Mef(A)	EXACTX	100.00	100.00	WP_000417519.1
APPLDMEG_8	2162	3622	msr(D)	ABC-F type ribosomal protection protein Msr(D)	EXACTX	100.00	100.00	WP_000420313.1

Virulence Factor Database (VFDB)

Query ID	qstart	qend	Gene name	e-value	VF name	VF category	Identity	Coverage	Accession no.
APPLDMEG_1	48654	50114	STU_RS14650	0.0	Capsule	Immune modulation	96.92	100.21	WP_011226049
APPLDMEG_1	48654	50114	STER_RS05320	0.0	Capsule	Immune modulation	96.85	100.00	WP_011681177
APPLDMEG_1	48654	50114	STR_RS05265	0.0	Capsule	Immune modulation	96.03	100.21	WP_041827043
APPLDMEG_19	77169	77978	STU_RS16245	0.0	Capsule	Immune modulation	95.31	100.00	WP_002948020
APPLDMEG_1	45049	46414	STER_RS05300	0.0	Capsule	Immune modulation	95.09	99.85	WP_011681173
APPLDMEG_19	85116	85967	rfbD	0.0	Capsule	Immune modulation	95.07	100.00	WP_014621820
APPLDMEG_1	46471	47211	STER_RS05305	0.0	Capsule	Immune modulation	94.87	100.00	WP_011681174
APPLDMEG_1	45047	46414	STU_RS14630	0.0	Capsule	Immune modulation	94.59	100.00	WP_011226045
APPLDMEG_1	46471	47211	STU_RS14635	0.0	Capsule	Immune modulation	94.33	100.00	WP_011226046
APPLDMEG_16	2648	3931	tig/ropA	0.0	Trigger factor	Stress survival	94.08	100.00	WP_011225339
APPLDMEG_1	46476	47211	STR_RS05250	0.0	Capsule	Immune modulation	93.89	98.13	WP_011227246
APPLDMEG_1	47922	48653	STER_RS05315	0.0	Capsule	Immune modulation	93.85	100.00	WP_011681176
APPLDMEG_1	47922	48653	STU_RS14645	0.0	Capsule	Immune modulation	93.72	100.00	WP_011226048
APPLDMEG_19	82744	84015	STU_RS16265	0.0	Capsule	Immune modulation	93.71	99.76	WP_011226331
APPLDMEG_19	75964	77169	STU_RS16240	0.0	Capsule	Immune modulation	93.53	100.00	WP_011226326
APPLDMEG_1	47922	48653	STR_RS05260	0.0	Capsule	Immune modulation	93.17	100.00	WP_011227248
APPLDMEG_19	73129	74913	STU_RS16230	0.0	Capsule	Immune modulation	92.94	100.00	WP_011226325
APPLDMEG_19	78915	80063	STU_RS16255	0.0	Capsule	Immune modulation	92.17	100.00	WP_041828290
APPLDMEG_18	80441	81034	STR_RS05880	0.0	Capsule	Immune modulation	91.92	100.00	WP_011226149
APPLDMEG_18	80441	81034	STER_RS06030	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
APPLDMEG_18	80441	81034	STU_RS15260	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
APPLDMEG_19	74910	75944	STU_RS16235	0.0	Capsule	Immune modulation	91.39	99.05	WP_002948022
APPLDMEG_19	77962	78918	STU_RS16250	0.0	Capsule	Immune modulation	91.33	100.00	WP_011226328
APPLDMEG_18	81034	81903	rfbA	0.0	Capsule	Immune modulation	91.03	100.00	WP_011681286
APPLDMEG_11	18537	20195	fbp54	0.0	FBPs	Adherence	90.36	99.94	WP_011227179
APPLDMEG_22	60689	61699	plr/gapA	0.0	Streptococcal plasmin receptor/GAPDH	Adherence	88.65	99.80	WP_002986042
APPLDMEG_1	47221	47913	STR_RS05255	0.0	Capsule	Immune modulation	88.47	99.86	WP_011227247
APPLDMEG_1	47221	47913	STU_RS14640	0.0	Capsule	Immune modulation	88.47	99.86	WP_011226047
APPLDMEG_15	18791	20094	eno	0.0	Streptococcal enolase	Exoenzyme	88.47	99.54	WP_000022832
APPLDMEG_20	6834	7739	cbpD	0.0	Autolysin	Exoenzyme	88.41	93.50	WP_082302295
APPLDMEG_1	47221	47913	STER_RS05310	0.0	Capsule	Immune modulation	88.18	99.86	WP_011681175
APPLDMEG_11	174680	175441	srtA	0.0	Sortase A	Exoenzyme	84.03	99.74	-
APPLDMEG_18	79192	80238	rfbB	0.0	Capsule	Immune modulation	80.42	100.00	WP_009659423

VirulenceFinder

Query ID	Begin	End	Database	Virulence factor	Protein function	Identity	Coverage	Accession no.
No hit found

PHI-base

Query ID	qstart	qend	Gene name	e-value	Function	Identity	Coverage	Gene ID
APPLDMEG_11	178131	179105	ldh(Sp_1220)	0.0	L-lactate dehydrogenase	96.92	99.09	AAK75326
APPLDMEG_11	166550	165477	MntE	0.0	manganese homeostasis	95.25	99.72	ABF32167
APPLDMEG_15	198363	196057	pfl2(Sp_0459)	0.0	formate acetyltransferase	94.41	99.22	AAK74619
APPLDMEG_11	333476	334957	SPD_0310	0.0	UPF0371 protein SPD_0310	93.12	100.00	ABJ54480
APPLDMEG_15	109893	108925	spr0084	0.0	pathogenitcity related	92.88	98.48	AAK98888
APPLDMEG_11	138495	136249	metE	0.0	methionine biosynthesis enzymes	92.39	100.00	AAK74738
APPLDMEG_5	35936	34965	prsA2	0.0	ribose-phosphate pyrophosphokinase	91.36	100.00	ABF36968
APPLDMEG_15	348899	350047	potA	0.0	ABC transporter ATP-binding protein-spermidine/putrescine transport	90.08	99.48	AAL00050
APPLDMEG_18	107288	105558	ptsI	0.0	phosphoenolpyruvate-protein phosphotransferase	89.95	100.00	AAK34199
APPLDMEG_19	99363	97375	uvrB	0.0	excinuclease ABC, B subunit	89.59	100.00	AE014259_2
APPLDMEG_17	163544	162066	IMPDH	0.0	inosine-5'-monophosphate dehydrogenase	87.63	100.00	ADE32434
APPLDMEG_15	20094	18793	Eno	0.0	enolase	86.44	99.77	ABP90468
APPLDMEG_17	148221	146329	gidA	0.0	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	85.26	98.90	ABP91129
APPLDMEG_11	133330	135039	PGM	0.0	phosphoglucomutase	84.76	99.65	ACH87041
APPLDMEG_5	2042	951	recA	0.0	DNA recombination and repair	84.64	95.36	AAL00560
APPLDMEG_17	28753	29763	pdh	0.0	pyruvate dehydrogenase	82.79	99.70	ABP91006
APPLDMEG_11	5016	6377	mnmE	0.0	central tRNA-modifying GTPase	82.46	99.56	ABP90420
APPLDMEG_15	34504	33614	bglB	4.63e-178	putative phospho--glucosidase	87.88	99.66	AAK33487
APPLDMEG_11	92681	93631	SP_0676	1.13e-169	transcription facot	81.39	98.45	AAK74821
APPLDMEG_11	136062	135205	metF	9.29e-168	methionine biosynthesis enzymes	87.06	99.31	AAK74739
APPLDMEG_7	426	1130	covR	3.37e-127	responder protein	85.11	100.00	AAK71319
APPLDMEG_11	261361	260690	rr01	8.08e-127	response regulator	84.82	99.56	CAB54566
APPLDMEG_11	129362	128691	ciaR	1.89e-124	two component system response regulator	85.71	99.12	AIK75708
APPLDMEG_11	129362	128694	CiaR	2.34e-124	two-component response regulator	87.00	99.55	AAK74935
APPLDMEG_7	426	1130	walR	6.19e-121	DNA-binding response regulator	81.70	100.00	ANC99504
APPLDMEG_16	162188	162874	CovR	4.80e-120	serves to repress GAS virulence factor-encoding genes	81.66	100.00	ACE75886
APPLDMEG_5	777	382	SpxA2	3.95e-76	transcriptional regulator	91.67	100.00	ERL21461
APPLDMEG_4	6454	6855	SpxA1	4.48e-70	transcriptional regulator	82.09	100.00	ERL19273
APPLDMEG_2	6355	5942	GrpE	9.69e-68	protein grpE	81.16	80.59	ABP89267
APPLDMEG_16	185967	186254	spr0479	5.81e-48	essential gene	85.42	98.97	AAK99283
APPLDMEG_20	59740	59994	spr1327	4.75e-45	essential gene	92.94	100.00	AAL00131
APPLDMEG_17	117225	117488	spr0175	9.79e-43	pathogenitcity related	85.23	100.00	AAK98979
APPLDMEG_17	118051	118317	spr0177	1.36e-41	essential gene	83.15	88.12	AAK98981
APPLDMEG_16	4098	4589	RopE (M5005_Spy_1611)	1.06e-72	probable DNA-directed RNA polymerase subunit delta	82.93	85.86	AAK34603
APPLDMEG_15	198363	196063	PFL (B9H01_RS01125)	0.0	formate C-acetyltransferase	83.09	98.08	MYN69560
APPLDMEG_17	65475	64456	ilvC (SPD_0406)	0.0	ketol-acid reductoisomerase (NADP(+))	96.77	100.00	ABJ55451