Genome ID：GCA_009717105.1

Potential risk score of uploaded strain

ARGs	VFs	PGs	PPRS
2	22	33	39.71

CARD

Query ID	Begin	End	ARO name	ARO accession	CARD name	Identity	Coverage	Accession no.
No hit found

Resfinder

Query ID	Begin	End	Resistance gene	Phenotype	Identity	Coverage	Accession no.
HIKEBFGN_10	275313	276530	mef(A)	Erythromycin, Azithromycin	100.00	100.00	U83667
HIKEBFGN_10	273730	275193	msr(D)	Erythromycin, Azithromycin, Telithromycin, Quinupristin, Pristinamycin IA, Virginiamycin S	100.00	100.00	AF274302

AMRFinderPlus

Query ID	Begin	End	Gene symbol	Sequence name	Method	Identity	Coverage	Accession no.
HIKEBFGN_10	275316	276530	mef(A)	macrolide efflux MFS transporter Mef(A)	EXACTX	100.00	100.00	WP_000417519.1
HIKEBFGN_10	273733	275193	msr(D)	ABC-F type ribosomal protection protein Msr(D)	EXACTX	100.00	100.00	WP_000420313.1

Virulence Factor Database (VFDB)

Query ID	qstart	qend	Gene name	e-value	VF name	VF category	Identity	Coverage	Accession no.
HIKEBFGN_16	49212	50672	STU_RS14650	0.0	Capsule	Immune modulation	96.92	100.21	WP_011226049
HIKEBFGN_16	49212	50672	STER_RS05320	0.0	Capsule	Immune modulation	96.85	100.00	WP_011681177
HIKEBFGN_16	49212	50672	STR_RS05265	0.0	Capsule	Immune modulation	96.03	100.21	WP_041827043
HIKEBFGN_12	75797	76606	STU_RS16245	0.0	Capsule	Immune modulation	95.31	100.00	WP_002948020
HIKEBFGN_16	45607	46972	STER_RS05300	0.0	Capsule	Immune modulation	95.09	99.85	WP_011681173
HIKEBFGN_12	83744	84595	rfbD	0.0	Capsule	Immune modulation	95.07	100.00	WP_014621820
HIKEBFGN_16	47029	47769	STER_RS05305	0.0	Capsule	Immune modulation	94.87	100.00	WP_011681174
HIKEBFGN_16	45605	46972	STU_RS14630	0.0	Capsule	Immune modulation	94.59	100.00	WP_011226045
HIKEBFGN_16	47029	47769	STU_RS14635	0.0	Capsule	Immune modulation	94.33	100.00	WP_011226046
HIKEBFGN_13	2648	3931	tig/ropA	0.0	Trigger factor	Stress survival	94.08	100.00	WP_011225339
HIKEBFGN_16	47034	47769	STR_RS05250	0.0	Capsule	Immune modulation	93.89	98.13	WP_011227246
HIKEBFGN_16	48480	49211	STER_RS05315	0.0	Capsule	Immune modulation	93.85	100.00	WP_011681176
HIKEBFGN_16	48480	49211	STU_RS14645	0.0	Capsule	Immune modulation	93.72	100.00	WP_011226048
HIKEBFGN_12	81372	82643	STU_RS16265	0.0	Capsule	Immune modulation	93.71	99.76	WP_011226331
HIKEBFGN_12	74592	75797	STU_RS16240	0.0	Capsule	Immune modulation	93.53	100.00	WP_011226326
HIKEBFGN_16	48480	49211	STR_RS05260	0.0	Capsule	Immune modulation	93.17	100.00	WP_011227248
HIKEBFGN_12	71757	73541	STU_RS16230	0.0	Capsule	Immune modulation	92.94	100.00	WP_011226325
HIKEBFGN_12	77543	78691	STU_RS16255	0.0	Capsule	Immune modulation	92.17	100.00	WP_041828290
HIKEBFGN_10	119958	120551	STR_RS05880	0.0	Capsule	Immune modulation	91.92	100.00	WP_011226149
HIKEBFGN_10	119958	120551	STER_RS06030	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
HIKEBFGN_10	119958	120551	STU_RS15260	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
HIKEBFGN_12	73538	74572	STU_RS16235	0.0	Capsule	Immune modulation	91.39	99.05	WP_002948022
HIKEBFGN_12	76590	77546	STU_RS16250	0.0	Capsule	Immune modulation	91.33	100.00	WP_011226328
HIKEBFGN_10	120551	121420	rfbA	0.0	Capsule	Immune modulation	91.03	100.00	WP_011681286
HIKEBFGN_11	364867	366525	fbp54	0.0	FBPs	Adherence	90.36	99.94	WP_011227179
HIKEBFGN_12	416204	417214	plr/gapA	0.0	Streptococcal plasmin receptor/GAPDH	Adherence	88.65	99.80	WP_002986042
HIKEBFGN_16	47779	48471	STR_RS05255	0.0	Capsule	Immune modulation	88.47	99.86	WP_011227247
HIKEBFGN_16	47779	48471	STU_RS14640	0.0	Capsule	Immune modulation	88.47	99.86	WP_011226047
HIKEBFGN_10	300714	302017	eno	0.0	Streptococcal enolase	Exoenzyme	88.47	99.54	WP_000022832
HIKEBFGN_15	1330	2235	cbpD	0.0	Autolysin	Exoenzyme	88.41	93.50	WP_082302295
HIKEBFGN_16	47779	48471	STER_RS05310	0.0	Capsule	Immune modulation	88.18	99.86	WP_011681175
HIKEBFGN_11	209621	210382	srtA	0.0	Sortase A	Exoenzyme	84.03	99.74	-
HIKEBFGN_10	118709	119755	rfbB	0.0	Capsule	Immune modulation	80.42	100.00	WP_009659423

VirulenceFinder

Query ID	Begin	End	Database	Virulence factor	Protein function	Identity	Coverage	Accession no.
No hit found

PHI-base

Query ID	qstart	qend	Gene name	e-value	Function	Identity	Coverage	Gene ID
HIKEBFGN_11	206931	205957	ldh(Sp_1220)	0.0	L-lactate dehydrogenase	96.92	99.09	AAK75326
HIKEBFGN_11	218512	219585	MntE	0.0	manganese homeostasis	95.25	99.72	ABF32167
HIKEBFGN_12	285218	287524	pfl2(Sp_0459)	0.0	formate acetyltransferase	94.41	99.22	AAK74619
HIKEBFGN_10	391814	390846	spr0084	0.0	pathogenitcity related	93.19	98.48	AAK98888
HIKEBFGN_11	51587	50106	SPD_0310	0.0	UPF0371 protein SPD_0310	93.12	100.00	ABJ54480
HIKEBFGN_11	246567	248813	metE	0.0	methionine biosynthesis enzymes	92.39	100.00	AAK74738
HIKEBFGN_1	35936	34965	prsA2	0.0	ribose-phosphate pyrophosphokinase	91.36	100.00	ABF36968
HIKEBFGN_12	134682	133534	potA	0.0	ABC transporter ATP-binding protein-spermidine/putrescine transport	90.08	99.48	AAL00050
HIKEBFGN_10	146805	145075	ptsI	0.0	phosphoenolpyruvate-protein phosphotransferase	89.95	100.00	AAK34199
HIKEBFGN_12	97991	96003	uvrB	0.0	excinuclease ABC, B subunit	89.59	100.00	AE014259_2
HIKEBFGN_14	163545	162067	IMPDH	0.0	inosine-5'-monophosphate dehydrogenase	87.63	100.00	ADE32434
HIKEBFGN_10	302017	300716	Eno	0.0	enolase	86.44	99.77	ABP90468
HIKEBFGN_14	148222	146330	gidA	0.0	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	85.26	98.90	ABP91129
HIKEBFGN_11	251732	250023	PGM	0.0	phosphoglucomutase	84.76	99.65	ACH87041
HIKEBFGN_1	2042	951	recA	0.0	DNA recombination and repair	84.64	95.36	AAL00560
HIKEBFGN_14	28753	29763	pdh	0.0	pyruvate dehydrogenase	82.79	99.70	ABP91006
HIKEBFGN_11	380046	378685	mnmE	0.0	central tRNA-modifying GTPase	82.46	99.56	ABP90420
HIKEBFGN_10	316427	315537	bglB	5.94e-178	putative phospho--glucosidase	87.88	99.66	AAK33487
HIKEBFGN_11	292381	291431	SP_0676	1.14e-169	transcription facot	81.39	98.45	AAK74821
HIKEBFGN_11	249000	249857	metF	9.35e-168	methionine biosynthesis enzymes	87.06	99.31	AAK74739
HIKEBFGN_3	426	1130	covR	3.37e-127	responder protein	85.11	100.00	AAK71319
HIKEBFGN_11	123702	124373	rr01	8.12e-127	response regulator	84.82	99.56	CAB54566
HIKEBFGN_11	255700	256371	ciaR	1.90e-124	two component system response regulator	85.71	99.12	AIK75708
HIKEBFGN_11	255700	256368	CiaR	2.36e-124	two-component response regulator	87.00	99.55	AAK74935
HIKEBFGN_3	426	1130	walR	6.19e-121	DNA-binding response regulator	81.70	100.00	ANC99504
HIKEBFGN_13	162188	162874	CovR	4.80e-120	serves to repress GAS virulence factor-encoding genes	81.66	100.00	ACE75886
HIKEBFGN_1	777	382	SpxA2	3.95e-76	transcriptional regulator	91.67	100.00	ERL21461
HIKEBFGN_11	391512	391913	SpxA1	4.70e-69	transcriptional regulator	82.09	100.00	ERL19273
HIKEBFGN_17	6355	5942	GrpE	9.69e-68	protein grpE	81.16	80.59	ABP89267
HIKEBFGN_13	185967	186254	spr0479	5.81e-48	essential gene	85.42	98.97	AAK99283
HIKEBFGN_10	428216	427962	spr1327	2.17e-44	essential gene	92.94	100.00	AAL00131
HIKEBFGN_14	117225	117488	spr0175	9.79e-43	pathogenitcity related	85.23	100.00	AAK98979
HIKEBFGN_14	118051	118317	spr0177	1.36e-41	essential gene	83.15	88.12	AAK98981
HIKEBFGN_13	4098	4589	RopE (M5005_Spy_1611)	1.06e-72	probable DNA-directed RNA polymerase subunit delta	82.93	85.86	AAK34603
HIKEBFGN_12	285218	287518	PFL (B9H01_RS01125)	0.0	formate C-acetyltransferase	83.09	98.08	MYN69560
HIKEBFGN_14	65475	64456	ilvC (SPD_0406)	0.0	ketol-acid reductoisomerase (NADP(+))	96.77	100.00	ABJ55451