Genome ID：GCA_041431765.1

Potential risk score of uploaded strain

ARGs	VFs	PGs	PPRS
2	20	33	38.64

CARD

Query ID	Begin	End	ARO name	ARO accession	CARD name	Identity	Coverage	Accession no.
No hit found

Resfinder

Query ID	Begin	End	Resistance gene	Phenotype	Identity	Coverage	Accession no.
KHMKAEIP_7	64175	65392	mef(A)	Erythromycin, Azithromycin	100.00	100.00	U83667
KHMKAEIP_7	65512	66975	msr(D)	Erythromycin, Azithromycin, Telithromycin, Quinupristin, Pristinamycin IA, Virginiamycin S	100.00	100.00	AF274302

AMRFinderPlus

Query ID	Begin	End	Gene symbol	Sequence name	Method	Identity	Coverage	Accession no.
KHMKAEIP_7	64175	65389	mef(A)	macrolide efflux MFS transporter Mef(A)	EXACTX	100.00	100.00	WP_000417519.1
KHMKAEIP_7	65512	66972	msr(D)	ABC-F type ribosomal protection protein Msr(D)	EXACTX	100.00	100.00	WP_000420313.1

Virulence Factor Database (VFDB)

Query ID	qstart	qend	Gene name	e-value	VF name	VF category	Identity	Coverage	Accession no.
KHMKAEIP_1	245812	246527	STER_RS07085	0.0	Capsule	Immune modulation	96.65	99.86	WP_011681442
KHMKAEIP_5	113693	114433	STER_RS05305	0.0	Capsule	Immune modulation	95.01	100.00	WP_011681174
KHMKAEIP_1	241651	242502	rfbD	0.0	Capsule	Immune modulation	94.72	100.00	WP_014621820
KHMKAEIP_1	244842	245810	STER_RS07090	0.0	Capsule	Immune modulation	94.63	100.00	WP_011681443
KHMKAEIP_5	113693	114433	STU_RS14635	0.0	Capsule	Immune modulation	94.33	100.00	WP_011226046
KHMKAEIP_5	110790	112250	STU_RS14650	0.0	Capsule	Immune modulation	94.05	100.14	WP_011226049
KHMKAEIP_5	114490	115857	STU_RS14630	0.0	Capsule	Immune modulation	93.93	100.00	WP_011226045
KHMKAEIP_5	110790	112250	STER_RS05320	0.0	Capsule	Immune modulation	93.91	100.00	WP_011681177
KHMKAEIP_5	113693	114428	STR_RS05250	0.0	Capsule	Immune modulation	93.75	98.13	WP_011227246
KHMKAEIP_5	114490	115855	STER_RS05300	0.0	Capsule	Immune modulation	93.63	99.85	WP_011681173
KHMKAEIP_5	110790	112250	STR_RS05265	0.0	Capsule	Immune modulation	93.16	100.14	WP_041827043
KHMKAEIP_1	246873	247649	STER_RS07075	0.0	Capsule	Immune modulation	92.66	100.00	WP_011681440
KHMKAEIP_1	242621	243874	STER_RS07100	0.0	Capsule	Immune modulation	92.51	99.52	WP_011681445
KHMKAEIP_5	112251	112982	STU_RS14645	0.0	Capsule	Immune modulation	91.94	100.00	WP_011226048
KHMKAEIP_9	24513	25106	STR_RS05880	0.0	Capsule	Immune modulation	91.75	100.00	WP_011226149
KHMKAEIP_9	24513	25106	STER_RS06030	0.0	Capsule	Immune modulation	91.58	100.00	WP_011226149
KHMKAEIP_9	24513	25106	STU_RS15260	0.0	Capsule	Immune modulation	91.58	100.00	WP_011226149
KHMKAEIP_5	112251	112982	STER_RS05315	0.0	Capsule	Immune modulation	91.53	100.00	WP_011681176
KHMKAEIP_9	23644	24513	rfbA	0.0	Capsule	Immune modulation	91.38	100.00	WP_011681286
KHMKAEIP_2	52164	53821	fbp54	0.0	FBPs	Adherence	91.14	99.88	WP_011227179
KHMKAEIP_5	112251	112982	STR_RS05260	0.0	Capsule	Immune modulation	90.98	100.00	WP_011227248
KHMKAEIP_13	18320	19159	cbpD	0.0	Autolysin	Exoenzyme	90.95	100.00	WP_011226733
KHMKAEIP_10	63680	64690	plr/gapA	0.0	Streptococcal plasmin receptor/GAPDH	Adherence	88.45	99.80	WP_002986042
KHMKAEIP_7	36067	37370	eno	0.0	Streptococcal enolase	Exoenzyme	88.24	99.54	WP_000022832
KHMKAEIP_5	112991	113683	STR_RS05255	0.0	Capsule	Immune modulation	88.04	99.86	WP_011227247
KHMKAEIP_5	112991	113683	STU_RS14640	0.0	Capsule	Immune modulation	88.04	99.86	WP_011226047
KHMKAEIP_5	112991	113683	STER_RS05310	0.0	Capsule	Immune modulation	87.46	99.86	WP_011681175
KHMKAEIP_2	199185	199946	srtA	0.0	Sortase A	Exoenzyme	84.40	99.87	-
KHMKAEIP_9	25309	26355	rfbB	0.0	Capsule	Immune modulation	83.97	99.90	WP_002263087
KHMKAEIP_4	1994	3277	tig/ropA	0.0	Trigger factor	Stress survival	80.84	99.61	WP_000107753
KHMKAEIP_5	124930	125515	SPD_RS01775	3.49e-147	Capsule	Immune modulation	82.96	96.53	WP_001819836

VirulenceFinder

Query ID	Begin	End	Database	Virulence factor	Protein function	Identity	Coverage	Accession no.
No hit found

PHI-base

Query ID	qstart	qend	Gene name	e-value	Function	Identity	Coverage	Gene ID
KHMKAEIP_2	202634	203617	ldh(Sp_1220)	0.0	L-lactate dehydrogenase	96.34	100.00	AAK75326
KHMKAEIP_2	191051	189978	MntE	0.0	manganese homeostasis	95.53	99.72	ABF32167
KHMKAEIP_1	60984	58678	pfl2(Sp_0459)	0.0	formate acetyltransferase	94.41	99.22	AAK74619
KHMKAEIP_8	21344	19863	SPD_0310	0.0	UPF0371 protein SPD_0310	93.32	100.00	ABJ54480
KHMKAEIP_2	171991	169745	metE	0.0	methionine biosynthesis enzymes	92.92	100.00	AAK74738
KHMKAEIP_6	58902	57934	spr0084	0.0	pathogenitcity related	92.88	98.48	AAK98888
KHMKAEIP_13	3899	4870	prsA2	0.0	ribose-phosphate pyrophosphokinase	91.67	100.00	ABF36968
KHMKAEIP_17	27775	29505	ptsI	0.0	phosphoenolpyruvate-protein phosphotransferase	89.95	100.00	AAK34199
KHMKAEIP_1	199385	200536	potA	0.0	ABC transporter ATP-binding protein-spermidine/putrescine transport	89.58	99.74	AAL00050
KHMKAEIP_1	227746	229734	uvrB	0.0	excinuclease ABC, B subunit	89.44	100.00	AE014259_2
KHMKAEIP_3	25733	27211	IMPDH	0.0	inosine-5'-monophosphate dehydrogenase	87.83	100.00	ADE32434
KHMKAEIP_7	36067	37368	Eno	0.0	enolase	86.44	99.77	ABP90468
KHMKAEIP_3	41106	42998	gidA	0.0	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	85.58	98.90	ABP91129
KHMKAEIP_2	166823	168532	PGM	0.0	phosphoglucomutase	84.76	99.65	ACH87041
KHMKAEIP_13	37836	38927	recA	0.0	DNA recombination and repair	84.64	95.36	AAL00560
KHMKAEIP_3	182267	181257	pdh	0.0	pyruvate dehydrogenase	83.38	99.70	ABP91006
KHMKAEIP_2	37700	39061	mnmE	0.0	central tRNA-modifying GTPase	82.24	99.56	ABP90420
KHMKAEIP_7	21651	22541	bglB	2.46e-177	putative phospho--glucosidase	87.20	99.66	AAK33487
KHMKAEIP_2	124315	125265	SP_0676	2.62e-170	transcription facot	81.39	98.45	AAK74821
KHMKAEIP_2	169555	168698	metF	2.48e-169	methionine biosynthesis enzymes	87.41	99.31	AAK74739
KHMKAEIP_34	2240	2911	rr01	2.35e-131	response regulator	84.38	99.56	CAB54566
KHMKAEIP_5	65124	65828	covR	7.30e-127	responder protein	85.53	100.00	AAK71319
KHMKAEIP_2	162856	162185	ciaR	2.43e-125	two component system response regulator	86.16	99.12	AIK75708
KHMKAEIP_2	162856	162188	CiaR	1.83e-124	two-component response regulator	87.00	99.55	AAK74935
KHMKAEIP_5	65124	65828	walR	1.66e-120	DNA-binding response regulator	82.13	100.00	ANC99504
KHMKAEIP_4	152514	153200	CovR	3.67e-120	serves to repress GAS virulence factor-encoding genes	81.66	100.00	ACE75886
KHMKAEIP_13	39101	39496	SpxA2	3.90e-76	transcriptional regulator	91.67	100.00	ERL21461
KHMKAEIP_2	26229	25828	SpxA1	5.42e-70	transcriptional regulator	82.84	100.00	ERL19273
KHMKAEIP_12	41738	42142	GrpE	8.27e-68	protein grpE	82.96	78.82	ABP89267
KHMKAEIP_15	4387	4674	spr0479	9.20e-49	essential gene	85.42	98.97	AAK99283
KHMKAEIP_6	91780	91526	spr1327	7.43e-45	essential gene	92.94	100.00	AAL00131
KHMKAEIP_3	90187	89924	spr0175	1.09e-42	pathogenitcity related	85.23	100.00	AAK98979
KHMKAEIP_3	89363	89097	spr0177	2.42e-41	essential gene	83.15	88.12	AAK98981
KHMKAEIP_4	3444	3935	RopE (M5005_Spy_1611)	8.12e-73	probable DNA-directed RNA polymerase subunit delta	82.93	85.86	AAK34603
KHMKAEIP_1	60984	58684	PFL (B9H01_RS01125)	0.0	formate C-acetyltransferase	83.09	98.08	MYN69560
KHMKAEIP_3	145829	146848	ilvC (SPD_0406)	0.0	ketol-acid reductoisomerase (NADP(+))	97.35	100.00	ABJ55451