Genome ID：GCA_047463215.1

Potential risk score of uploaded strain

ARGs	VFs	PGs	PPRS
2	16	35	38.54

CARD

Query ID	Begin	End	ARO name	ARO accession	CARD name	Identity	Coverage	Accession no.
No hit found

Resfinder

Query ID	Begin	End	Resistance gene	Phenotype	Identity	Coverage	Accession no.
CMHDLHII_13	20069	21286	mef(A)	Erythromycin, Azithromycin	100.00	100.00	U83667
CMHDLHII_13	18486	19949	msr(D)	Erythromycin, Azithromycin, Telithromycin, Quinupristin, Pristinamycin IA, Virginiamycin S	100.00	100.00	AF274302

AMRFinderPlus

Query ID	Begin	End	Gene symbol	Sequence name	Method	Identity	Coverage	Accession no.
CMHDLHII_13	20072	21286	mef(A)	macrolide efflux MFS transporter Mef(A)	EXACTX	100.00	100.00	WP_000417519.1
CMHDLHII_13	18489	19949	msr(D)	ABC-F type ribosomal protection protein Msr(D)	EXACTX	100.00	100.00	WP_000420313.1

Virulence Factor Database (VFDB)

Query ID	qstart	qend	Gene name	e-value	VF name	VF category	Identity	Coverage	Accession no.
CMHDLHII_9	50920	51651	STR_RS05260	0.0	Capsule	Immune modulation	94.54	100.00	WP_011227248
CMHDLHII_4	23798	24514	STER_RS07085	0.0	Capsule	Immune modulation	94.42	100.00	WP_011681442
CMHDLHII_4	20222	21073	rfbD	0.0	Capsule	Immune modulation	94.37	100.00	WP_014621820
CMHDLHII_9	50920	51651	STU_RS14645	0.0	Capsule	Immune modulation	93.85	100.00	WP_011226048
CMHDLHII_9	50920	51651	STER_RS05315	0.0	Capsule	Immune modulation	93.58	100.00	WP_011681176
CMHDLHII_4	24860	25630	STER_RS07075	0.0	Capsule	Immune modulation	92.35	99.23	WP_011681440
CMHDLHII_9	49459	50919	STER_RS05320	0.0	Capsule	Immune modulation	91.26	99.86	WP_011681177
CMHDLHII_5	134978	135571	STR_RS05880	0.0	Capsule	Immune modulation	91.25	100.00	WP_011226149
CMHDLHII_5	134978	135571	STER_RS06030	0.0	Capsule	Immune modulation	91.08	100.00	WP_011226149
CMHDLHII_5	134978	135571	STU_RS15260	0.0	Capsule	Immune modulation	91.08	100.00	WP_011226149
CMHDLHII_9	49459	50919	STU_RS14650	0.0	Capsule	Immune modulation	90.65	100.00	WP_011226049
CMHDLHII_14	39530	41187	fbp54	0.0	FBPs	Adherence	90.30	99.88	WP_011227179
CMHDLHII_9	49459	50919	STR_RS05265	0.0	Capsule	Immune modulation	89.97	100.00	WP_041827043
CMHDLHII_9	51660	52352	STU_RS14640	0.0	Capsule	Immune modulation	89.90	100.00	WP_011226047
CMHDLHII_9	51660	52352	STR_RS05255	0.0	Capsule	Immune modulation	89.61	100.00	WP_011227247
CMHDLHII_9	51660	52352	STER_RS05310	0.0	Capsule	Immune modulation	89.47	100.00	WP_011681175
CMHDLHII_13	40960	42263	eno	0.0	Streptococcal enolase	Exoenzyme	88.24	99.54	WP_000022832
CMHDLHII_10	12044	12883	cbpD	0.0	Autolysin	Exoenzyme	87.87	99.88	WP_011226733
CMHDLHII_20	16125	17138	plr/gapA	0.0	Streptococcal plasmin receptor/GAPDH	Adherence	85.67	99.90	WP_002986042
CMHDLHII_7	80693	81454	srtA	0.0	Sortase A	Exoenzyme	84.40	99.87	-
CMHDLHII_5	133662	134708	rfbB	0.0	Capsule	Immune modulation	83.59	99.90	WP_002263087
CMHDLHII_29	8443	9726	tig/ropA	0.0	Trigger factor	Stress survival	80.76	99.61	WP_000107753
CMHDLHII_5	135571	136440	rfbA	0.0	Capsule	Immune modulation	80.28	99.77	WP_002904719
CMHDLHII_9	52362	53032	STU_RS14635	1.16e-149	Capsule	Immune modulation	81.13	90.28	WP_011226046
CMHDLHII_9	52362	53032	STER_RS05305	5.42e-148	Capsule	Immune modulation	80.98	90.28	WP_011681174
CMHDLHII_9	52362	53032	STR_RS05250	5.50e-138	Capsule	Immune modulation	80.09	89.20	WP_011227246

VirulenceFinder

Query ID	Begin	End	Database	Virulence factor	Protein function	Identity	Coverage	Accession no.
No hit found

PHI-base

Query ID	qstart	qend	Gene name	e-value	Function	Identity	Coverage	Gene ID
CMHDLHII_7	84143	85126	ldh(Sp_1220)	0.0	L-lactate dehydrogenase	96.95	100.00	AAK75326
CMHDLHII_7	72555	71482	MntE	0.0	manganese homeostasis	96.09	99.72	ABF32167
CMHDLHII_1	87528	85222	pfl2(Sp_0459)	0.0	formate acetyltransferase	94.41	99.22	AAK74619
CMHDLHII_15	35357	34389	spr0084	0.0	pathogenitcity related	93.19	98.48	AAK98888
CMHDLHII_2	96281	94800	SPD_0310	0.0	UPF0371 protein SPD_0310	93.12	100.00	ABJ54480
CMHDLHII_7	53495	51249	metE	0.0	methionine biosynthesis enzymes	92.79	100.00	AAK74738
CMHDLHII_19	5382	6353	prsA2	0.0	ribose-phosphate pyrophosphokinase	91.36	100.00	ABF36968
CMHDLHII_11	3567	1837	ptsI	0.0	phosphoenolpyruvate-protein phosphotransferase	89.95	100.00	AAK34199
CMHDLHII_4	5089	7077	uvrB	0.0	excinuclease ABC, B subunit	89.74	100.00	AE014259_2
CMHDLHII_1	282590	283741	potA	0.0	ABC transporter ATP-binding protein-spermidine/putrescine transport	89.58	99.74	AAL00050
CMHDLHII_18	37636	36158	IMPDH	0.0	inosine-5'-monophosphate dehydrogenase	87.83	100.00	ADE32434
CMHDLHII_13	42263	40962	Eno	0.0	enolase	86.44	99.77	ABP90468
CMHDLHII_18	22286	20394	gidA	0.0	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	85.58	98.90	ABP91129
CMHDLHII_19	41093	42184	recA	0.0	DNA recombination and repair	84.91	95.36	AAL00560
CMHDLHII_7	48331	50040	PGM	0.0	phosphoglucomutase	84.59	99.65	ACH87041
CMHDLHII_14	25768	27129	mnmE	0.0	central tRNA-modifying GTPase	82.89	99.56	ABP90420
CMHDLHII_8	92049	91039	pdh	0.0	pyruvate dehydrogenase	82.79	99.70	ABP91006
CMHDLHII_13	56669	55779	bglB	7.98e-179	putative phospho--glucosidase	87.88	99.66	AAK33487
CMHDLHII_7	8362	9312	SP_0676	1.75e-170	transcription facot	81.39	98.45	AAK74821
CMHDLHII_7	51059	50202	metF	1.35e-168	methionine biosynthesis enzymes	86.71	99.31	AAK74739
CMHDLHII_11	41180	42037	mtsA	2.22e-152	substrate-binding lipoprotein of manganese transporter	80.49	92.86	AIK76191
CMHDLHII_4	20222	21043	GacA	2.94e-147	dTDP-4-dehydrorhamnose reductas	80.29	96.48	AAZ51220
CMHDLHII_2	167041	167712	rr01	4.27e-127	response regulator	84.82	99.56	CAB54566
CMHDLHII_9	17152	17856	covR	5.76e-127	responder protein	85.53	100.00	AAK71319
CMHDLHII_7	43666	42995	ciaR	1.14e-125	two component system response regulator	86.16	99.12	AIK75708
CMHDLHII_7	43666	42998	CiaR	2.11e-125	two-component response regulator	87.44	99.55	AAK74935
CMHDLHII_3	134605	135291	CovR	1.58e-120	serves to repress GAS virulence factor-encoding genes	82.10	100.00	ACE75886
CMHDLHII_9	17152	17856	walR	5.12e-120	DNA-binding response regulator	81.70	100.00	ANC99504
CMHDLHII_19	42357	42752	SpxA2	4.22e-76	transcriptional regulator	91.67	100.00	ERL21461
CMHDLHII_14	14311	13910	SpxA1	4.06e-70	transcriptional regulator	82.09	100.00	ERL19273
CMHDLHII_12	67813	68226	GrpE	5.78e-68	protein grpE	81.88	80.59	ABP89267
CMHDLHII_3	157811	158098	spr0479	1.03e-47	essential gene	85.42	98.97	AAK99283
CMHDLHII_23	17021	17275	spr1327	8.18e-45	essential gene	90.59	100.00	AAL00131
CMHDLHII_8	1266	1003	spr0175	5.76e-43	pathogenitcity related	85.23	100.00	AAK98979
CMHDLHII_8	441	175	spr0177	1.28e-41	essential gene	83.15	88.12	AAK98981
CMHDLHII_29	8276	7785	RopE (M5005_Spy_1611)	5.08e-74	probable DNA-directed RNA polymerase subunit delta	82.93	85.86	AAK34603
CMHDLHII_1	87528	85228	PFL (B9H01_RS01125)	0.0	formate C-acetyltransferase	83.22	98.08	MYN69560
CMHDLHII_8	55910	56929	ilvC (SPD_0406)	0.0	ketol-acid reductoisomerase (NADP(+))	85.88	100.00	ABJ55451
CMHDLHII_14	54173	53634	pnuC	1.47e-98	NAD salvage pathway importer	88.33	66.91	AAK75931