Read a JSON File

ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
CODMFHAM_00001	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CODMFHAM_00002	7.77e-260	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
CODMFHAM_00003	1.4e-40	yyzM	-	-	S	-	-	-	Protein conserved in bacteria
CODMFHAM_00004	1.51e-258	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
CODMFHAM_00005	8.59e-133	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
CODMFHAM_00006	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CODMFHAM_00007	3.77e-53	yabO	-	-	J	-	-	-	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
CODMFHAM_00008	1.16e-80	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
CODMFHAM_00009	1.94e-05	-	-	-	-	-	-	-	-
CODMFHAM_00010	3.78e-307	-	3.5.2.6	-	V	ko:K01467	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01000	Beta-lactamase enzyme family
CODMFHAM_00011	8.87e-306	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
CODMFHAM_00012	2.22e-126	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
CODMFHAM_00013	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CODMFHAM_00014	1.79e-41	-	-	-	-	-	-	-	-
CODMFHAM_00015	1.93e-171	-	-	-	L	-	-	-	Transposase
CODMFHAM_00016	6.62e-62	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00017	1.74e-30	-	-	-	L	-	-	-	Transposase
CODMFHAM_00018	7.11e-39	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00019	1.4e-123	-	-	-	L	ko:K07497	-	ko00000	Transposase and inactivated derivatives
CODMFHAM_00028	1.93e-179	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
CODMFHAM_00029	2.7e-115	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CODMFHAM_00030	2.5e-168	pcsB	-	-	S	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain
CODMFHAM_00031	2.75e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CODMFHAM_00032	2.13e-278	araT	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
CODMFHAM_00033	5.05e-186	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
CODMFHAM_00034	1.28e-229	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
CODMFHAM_00035	1.93e-46	acpP_1	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CODMFHAM_00036	1.5e-167	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
CODMFHAM_00037	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CODMFHAM_00038	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CODMFHAM_00039	5.98e-242	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
CODMFHAM_00040	6.58e-130	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CODMFHAM_00041	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
CODMFHAM_00042	9.22e-64	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00043	1.66e-69	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00044	8.38e-46	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain protein
CODMFHAM_00045	7.27e-206	-	-	-	S	-	-	-	CHAP domain
CODMFHAM_00046	8.2e-306	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
CODMFHAM_00047	2.66e-99	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CODMFHAM_00048	1.46e-261	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CODMFHAM_00049	6.89e-181	-	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Ketopantoate reductase
CODMFHAM_00050	3.66e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CODMFHAM_00051	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CODMFHAM_00052	1.36e-90	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
CODMFHAM_00053	5.42e-75	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
CODMFHAM_00054	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CODMFHAM_00055	5.51e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
CODMFHAM_00056	9.81e-68	-	-	-	KT	-	-	-	phosphorelay signal transduction system
CODMFHAM_00058	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CODMFHAM_00060	7.26e-133	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
CODMFHAM_00061	5.43e-138	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	3-methyladenine DNA glycosylase
CODMFHAM_00062	8.37e-296	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
CODMFHAM_00063	2.51e-261	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CODMFHAM_00064	1.27e-86	spxA_2	1.20.4.1	-	P	ko:K00537,ko:K16509	-	ko00000,ko01000	Belongs to the ArsC family
CODMFHAM_00076	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CODMFHAM_00077	1.2e-299	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
CODMFHAM_00078	4.88e-49	XK27_02060	-	-	S	-	-	-	Transglycosylase associated protein
CODMFHAM_00079	1.76e-35	badR	-	-	K	ko:K15973	-	ko00000,ko03000	DNA-binding transcription factor activity
CODMFHAM_00080	5.19e-66	XK27_03570	-	-	S	ko:K19784	-	ko00000	reductase
CODMFHAM_00081	1.11e-47	XK27_03570	-	-	S	ko:K19784	-	ko00000	reductase
CODMFHAM_00083	2.48e-176	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
CODMFHAM_00084	1.73e-232	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CODMFHAM_00085	8.37e-108	-	-	-	S	-	-	-	Putative small multi-drug export protein
CODMFHAM_00086	2.83e-99	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
CODMFHAM_00087	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
CODMFHAM_00088	1.83e-165	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
CODMFHAM_00089	3.75e-72	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
CODMFHAM_00090	2.92e-294	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
CODMFHAM_00091	4.9e-140	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
CODMFHAM_00092	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
CODMFHAM_00093	9.06e-184	-	-	-	S	-	-	-	SseB protein N-terminal domain
CODMFHAM_00094	7.75e-145	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	serine acetyltransferase
CODMFHAM_00095	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
CODMFHAM_00096	2.1e-90	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CODMFHAM_00099	1.23e-172	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CODMFHAM_00100	6.97e-121	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
CODMFHAM_00101	2.6e-198	yitS	-	-	S	-	-	-	DegV family
CODMFHAM_00103	1.38e-44	-	-	-	K	-	-	-	helix-turn-helix
CODMFHAM_00104	2.32e-233	ykpB	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CODMFHAM_00105	7.02e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CODMFHAM_00106	1.49e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
CODMFHAM_00107	1.47e-47	-	-	-	K	-	-	-	sequence-specific DNA binding
CODMFHAM_00109	7.8e-94	-	-	-	S	ko:K20483	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lantibiotic dehydratase, C terminus
CODMFHAM_00110	0.0	-	-	-	S	ko:K20483	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lantibiotic dehydratase, C terminus
CODMFHAM_00111	1.36e-293	spaC2	-	-	V	ko:K20484	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lanthionine synthetase C family protein
CODMFHAM_00112	5.02e-82	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
CODMFHAM_00113	7.02e-133	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
CODMFHAM_00114	2.37e-153	-	-	-	-	-	-	-	-
CODMFHAM_00115	4.08e-34	isp2	-	-	S	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	pathogenesis
CODMFHAM_00116	9.65e-47	isp2	-	-	S	-	-	-	pathogenesis
CODMFHAM_00117	6.53e-118	-	-	-	L	ko:K07498	-	ko00000	Transposase
CODMFHAM_00118	8.88e-179	capA	-	-	M	ko:K07282	-	ko00000	Bacterial capsule synthesis protein
CODMFHAM_00119	8.65e-73	capA	-	-	M	ko:K07282	-	ko00000	Bacterial capsule synthesis protein
CODMFHAM_00120	3.56e-52	XK27_08630	-	-	T	ko:K07166	-	ko00000	UPF0237 protein
CODMFHAM_00121	5.6e-308	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
CODMFHAM_00122	1.51e-171	gpmB	-	-	G	ko:K15640	-	ko00000	Phosphoglycerate mutase
CODMFHAM_00123	6.07e-182	yodJ	3.4.16.4, 3.4.17.14	-	M	ko:K01286,ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
CODMFHAM_00124	8.86e-133	acmA	3.2.1.17	-	NU	ko:K01185,ko:K02395	-	ko00000,ko01000,ko02035	amidase activity
CODMFHAM_00125	4.82e-254	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
CODMFHAM_00126	3.24e-100	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CODMFHAM_00127	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
CODMFHAM_00128	4.85e-258	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
CODMFHAM_00129	7.45e-179	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
CODMFHAM_00130	1.05e-176	thiD	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	phosphomethylpyrimidine kinase
CODMFHAM_00131	6.84e-95	hmpT	-	-	S	-	-	-	cog cog4720
CODMFHAM_00133	0.0	amiA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
CODMFHAM_00134	6.39e-207	-	-	-	L	-	-	-	Transposase
CODMFHAM_00136	1e-74	amd	-	-	E	-	-	-	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CODMFHAM_00137	9.7e-298	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
CODMFHAM_00138	8.57e-114	-	-	-	-	-	-	-	-
CODMFHAM_00139	7.24e-102	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	DNA-templated transcription, initiation
CODMFHAM_00140	2.39e-191	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
CODMFHAM_00141	6.47e-286	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
CODMFHAM_00142	3.71e-119	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
CODMFHAM_00143	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
CODMFHAM_00144	5.04e-109	XK27_03960	-	-	S	-	-	-	Protein of unknown function (DUF3013)
CODMFHAM_00145	5.14e-105	-	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
CODMFHAM_00146	1.49e-224	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
CODMFHAM_00147	7.42e-174	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
CODMFHAM_00148	2.32e-35	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00149	4.85e-104	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00150	5.19e-59	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00151	2.26e-176	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00152	3.62e-41	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00153	4.79e-108	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
CODMFHAM_00154	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CODMFHAM_00155	4.95e-98	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
CODMFHAM_00156	3.09e-13	dex	3.2.1.11	GH66	G	ko:K05988	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 66
CODMFHAM_00157	9.63e-31	dex	3.2.1.11	GH66	G	ko:K05988	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 66
CODMFHAM_00158	5.94e-74	dex	3.2.1.11	GH66	G	ko:K05988	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 66
CODMFHAM_00159	3.02e-65	dex	3.2.1.11	GH66	G	ko:K05988	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 66
CODMFHAM_00160	6.73e-19	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CODMFHAM_00161	5.68e-270	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CODMFHAM_00162	2.96e-145	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
CODMFHAM_00163	1.1e-144	-	-	-	K	-	-	-	Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
CODMFHAM_00164	7.1e-256	XK27_00055	-	-	P	-	-	-	Major Facilitator
CODMFHAM_00165	1.74e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CODMFHAM_00166	8.47e-126	-	-	-	V	-	-	-	VanZ like family
CODMFHAM_00167	1.42e-09	-	-	-	D	-	-	-	nuclear chromosome segregation
CODMFHAM_00169	4.26e-168	glnQ	-	-	E	ko:K17076	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_00170	0.0	XK27_05795	-	-	P	ko:K17073,ko:K17074	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
CODMFHAM_00171	2.48e-196	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
CODMFHAM_00172	2.48e-173	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
CODMFHAM_00173	7.24e-248	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	transferase
CODMFHAM_00174	1.82e-184	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	ABC-type transport system involved in Fe-S cluster assembly, ATPase component
CODMFHAM_00175	1.7e-298	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
CODMFHAM_00176	4.01e-301	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CODMFHAM_00177	2.78e-98	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
CODMFHAM_00178	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
CODMFHAM_00179	9.6e-23	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
CODMFHAM_00180	1.64e-179	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
CODMFHAM_00181	1.6e-36	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CODMFHAM_00182	4.03e-14	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CODMFHAM_00183	9.54e-106	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CODMFHAM_00184	2.59e-75	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CODMFHAM_00185	3.36e-38	oppD	-	-	P	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00186	1.15e-43	oppD	-	-	P	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00187	9.75e-90	-	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00188	3.05e-60	oppD	-	-	P	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00189	7.91e-21	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00190	2.81e-15	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00191	9.7e-122	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_00192	2.04e-05	-	-	-	-	-	-	-	-
CODMFHAM_00193	1.2e-15	-	-	-	-	-	-	-	-
CODMFHAM_00194	9.47e-202	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CODMFHAM_00195	2.41e-234	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CODMFHAM_00196	1.43e-249	-	-	-	EGP	-	-	-	Major facilitator Superfamily
CODMFHAM_00197	1.28e-94	adcR	-	-	K	-	-	-	transcriptional
CODMFHAM_00198	8.76e-176	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
CODMFHAM_00199	3.81e-167	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_00200	2.93e-208	mleP2	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
CODMFHAM_00201	3.9e-37	ptsG	2.7.1.208	-	G	ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_00202	5.29e-193	ptsG	2.7.1.208	-	G	ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_00203	5.34e-108	-	2.7.1.208	-	G	ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
CODMFHAM_00204	2.33e-192	rgfB	3.1.3.90	-	L	ko:K06896	ko00500,map00500	ko00000,ko00001,ko01000	endonuclease exonuclease phosphatase family protein
CODMFHAM_00205	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
CODMFHAM_00206	9.23e-162	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
CODMFHAM_00207	5.37e-65	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	protein transport
CODMFHAM_00208	1.76e-182	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CODMFHAM_00209	1.29e-187	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
CODMFHAM_00210	6.34e-294	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
CODMFHAM_00211	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
CODMFHAM_00212	1.53e-212	-	-	-	L	ko:K07497	-	ko00000	integrase core domain
CODMFHAM_00213	0.0	XK27_00665	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter substrate binding protein
CODMFHAM_00214	8.63e-183	cmpC	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_00215	4.47e-57	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CODMFHAM_00216	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
CODMFHAM_00217	4.1e-97	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00220	1.35e-56	-	-	-	-	-	-	-	-
CODMFHAM_00221	1.89e-73	WQ51_06355	-	-	S	-	-	-	TM2 domain
CODMFHAM_00222	1.12e-210	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
CODMFHAM_00223	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
CODMFHAM_00224	2.56e-34	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Belongs to the SecE SEC61-gamma family
CODMFHAM_00225	2.8e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
CODMFHAM_00226	5.82e-96	-	3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27	-	I	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	ko00000,ko00001,ko01000,ko01011	phosphatidate phosphatase activity
CODMFHAM_00227	6.76e-73	cof	-	-	Q	-	-	-	phosphatase activity
CODMFHAM_00228	2.21e-46	cof	-	-	Q	-	-	-	phosphatase activity
CODMFHAM_00229	6.37e-101	-	-	-	K	ko:K22103	-	ko00000,ko03000	transcriptional regulator (DeoR family)
CODMFHAM_00230	7.72e-49	-	-	-	K	ko:K22103	-	ko00000,ko03000	transcriptional regulator (DeoR family)
CODMFHAM_00231	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
CODMFHAM_00232	3e-54	napB	-	-	K	-	-	-	transcriptional
CODMFHAM_00233	4.06e-116	-	-	-	S	ko:K06889	-	ko00000	thiolester hydrolase activity
CODMFHAM_00234	9.44e-184	-	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
CODMFHAM_00235	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CODMFHAM_00236	6.15e-195	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
CODMFHAM_00237	1.37e-99	yhaI	-	-	L	-	-	-	Membrane
CODMFHAM_00238	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
CODMFHAM_00239	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
CODMFHAM_00240	1.72e-141	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
CODMFHAM_00241	8.82e-124	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
CODMFHAM_00242	1.97e-66	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
CODMFHAM_00243	6.16e-283	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
CODMFHAM_00244	0.0	mapZ	-	-	D	ko:K20073	-	ko00000	Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
CODMFHAM_00245	0.0	snf	-	-	L	-	-	-	Superfamily II DNA RNA helicases, SNF2 family'
CODMFHAM_00246	7.28e-27	XK27_11680	-	-	-	-	-	-	-
CODMFHAM_00247	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
CODMFHAM_00248	1.83e-106	XK27_09675	-	-	K	ko:K07105	-	ko00000	-acetyltransferase
CODMFHAM_00249	0.0	mltG	-	-	ADL	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CODMFHAM_00250	1.17e-100	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
CODMFHAM_00251	1.51e-05	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00252	1.37e-109	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain protein
CODMFHAM_00253	1.52e-211	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CODMFHAM_00254	9.51e-61	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
CODMFHAM_00255	7.97e-168	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CODMFHAM_00256	3.36e-120	XK27_09705	-	-	S	ko:K06950	-	ko00000	HD superfamily hydrolase
CODMFHAM_00257	2.43e-145	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
CODMFHAM_00260	1.42e-310	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
CODMFHAM_00261	3.67e-120	-	-	-	K	-	-	-	transcriptional regulator
CODMFHAM_00262	5.74e-48	-	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
CODMFHAM_00263	5.43e-188	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
CODMFHAM_00264	1.64e-236	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CODMFHAM_00265	7.82e-128	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
CODMFHAM_00266	8.64e-112	ykuL	-	-	S	-	-	-	CBS domain
CODMFHAM_00267	3.55e-176	xerD	-	-	L	-	-	-	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
CODMFHAM_00268	3.35e-156	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CODMFHAM_00269	7.56e-129	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CODMFHAM_00270	3.14e-179	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
CODMFHAM_00271	1.81e-54	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
CODMFHAM_00272	0.0	trkH	-	-	P	ko:K03498	-	ko00000,ko02000	Cation transport protein
CODMFHAM_00273	4e-314	trkA	-	-	P	ko:K03499	-	ko00000,ko02000	Potassium transporter peripheral membrane component
CODMFHAM_00274	1.34e-125	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
CODMFHAM_00275	3.25e-116	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CODMFHAM_00276	1.56e-146	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Membrane-associated phospholipid phosphatase
CODMFHAM_00277	1.03e-206	-	-	-	K	ko:K20342,ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
CODMFHAM_00278	1.13e-44	-	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	protein secretion by the type I secretion system
CODMFHAM_00279	3.79e-145	comA	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CODMFHAM_00280	6.07e-59	-	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	protein secretion by the type I secretion system
CODMFHAM_00281	2.72e-36	comA	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	protein secretion by the type I secretion system
CODMFHAM_00282	1.34e-89	comA	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CODMFHAM_00283	4.39e-59	yhaI	-	-	L	-	-	-	Membrane
CODMFHAM_00284	1.08e-102	-	-	-	S	-	-	-	Domain of unknown function (DUF4173)
CODMFHAM_00285	2.16e-124	ureI	-	-	S	ko:K03191	ko05120,map05120	ko00000,ko00001,ko02000	AmiS/UreI family transporter
CODMFHAM_00286	1.02e-61	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease gamma subunit family
CODMFHAM_00287	3.78e-72	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease beta subunit family
CODMFHAM_00288	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
CODMFHAM_00289	2.74e-101	ureE	-	-	O	ko:K03187	-	ko00000	enzyme active site formation
CODMFHAM_00290	7.44e-169	ureF	-	-	O	ko:K03188	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CODMFHAM_00291	4.71e-142	ureG	-	-	KO	ko:K03189	-	ko00000	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CODMFHAM_00292	2.53e-206	ureD	-	-	O	ko:K03190	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CODMFHAM_00293	9.67e-225	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PDGLE domain
CODMFHAM_00294	1.37e-175	nikQ	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport protein
CODMFHAM_00295	3.03e-168	-	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
CODMFHAM_00296	3.2e-121	ureD	-	-	O	ko:K03190	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
CODMFHAM_00297	9.67e-225	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PDGLE domain
CODMFHAM_00298	1.37e-175	nikQ	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport protein
CODMFHAM_00299	3.03e-168	-	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
CODMFHAM_00300	2.79e-191	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	amino acid transport
CODMFHAM_00301	1.26e-212	metQ	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
CODMFHAM_00302	2.89e-31	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
CODMFHAM_00303	1.04e-59	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
CODMFHAM_00304	1.48e-82	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase activity
CODMFHAM_00305	3.26e-81	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase activity
CODMFHAM_00306	8.82e-243	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CODMFHAM_00307	1.77e-143	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_00308	1.79e-268	sstT	-	-	E	ko:K07862	-	ko00000,ko02000	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CODMFHAM_00309	3.48e-44	salL	2.5.1.63, 2.5.1.94	-	F	ko:K09134,ko:K21153,ko:K22205	-	ko00000,ko01000	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CODMFHAM_00310	4.54e-139	ilvH	-	-	S	-	-	-	S-adenosyl-l-methionine hydroxide adenosyltransferase
CODMFHAM_00311	5.41e-123	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
CODMFHAM_00312	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_00313	9.72e-189	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
CODMFHAM_00314	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CODMFHAM_00315	1.95e-14	ulaG	-	-	S	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	L-ascorbate 6-phosphate lactonase
CODMFHAM_00316	1.98e-157	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
CODMFHAM_00317	2.88e-309	ktrB	-	-	P	ko:K03498	-	ko00000,ko02000	COG0168 Trk-type K transport systems, membrane components
CODMFHAM_00318	1.5e-168	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Ribosomal RNA small subunit methyltransferase G
CODMFHAM_00319	6.87e-120	ylbN	-	-	K	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
CODMFHAM_00320	2.69e-158	csrR	-	-	T	-	-	-	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CODMFHAM_00321	0.0	covS	-	-	T	-	-	-	Histidine kinase
CODMFHAM_00322	1.46e-106	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CODMFHAM_00323	2.59e-276	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Replication initiation and membrane attachment
CODMFHAM_00324	5.34e-214	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
CODMFHAM_00325	2.06e-314	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
CODMFHAM_00326	0.0	-	-	-	P	-	-	-	ABC transporter transmembrane region
CODMFHAM_00327	4.37e-40	is18	-	-	L	-	-	-	COG2801 Transposase and inactivated derivatives
CODMFHAM_00328	3.42e-30	is18	-	-	L	-	-	-	COG2801 Transposase and inactivated derivatives
CODMFHAM_00330	1.53e-125	-	-	-	-	-	-	-	-
CODMFHAM_00331	1.17e-43	-	-	-	S	-	-	-	ABC-2 type transporter
CODMFHAM_00332	4.42e-161	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
CODMFHAM_00333	5.67e-307	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CODMFHAM_00334	1.85e-82	manO	-	-	S	-	-	-	protein conserved in bacteria
CODMFHAM_00335	8.21e-215	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose fructose sorbose family IID component
CODMFHAM_00336	6.22e-164	manM	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	pts system
CODMFHAM_00337	6.6e-230	manL	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_00338	1.84e-181	XK27_00940	3.5.1.9	-	S	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	ko00000,ko00001,ko00002,ko01000	Metal-dependent hydrolase
CODMFHAM_00339	1.46e-196	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
CODMFHAM_00340	2.72e-315	XK27_07275	-	-	S	ko:K06901	-	ko00000,ko02000	permease
CODMFHAM_00341	1.54e-101	ydiB	-	-	M	ko:K06925	-	ko00000,ko03016	ATPase or kinase
CODMFHAM_00342	6.67e-120	-	-	-	M	-	-	-	Acetyltransferase GNAT Family
CODMFHAM_00343	2.05e-277	brpA	-	-	K	-	-	-	Transcriptional
CODMFHAM_00344	3.06e-105	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
CODMFHAM_00345	2.28e-270	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
CODMFHAM_00346	6.68e-64	ylxR	-	-	K	ko:K07742	-	ko00000	Nucleic-acid-binding protein implicated in transcription termination
CODMFHAM_00347	2.19e-56	ylxQ	-	-	J	-	-	-	ribosomal protein
CODMFHAM_00348	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CODMFHAM_00349	9.81e-77	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CODMFHAM_00350	3.78e-58	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	cytokinin biosynthetic process
CODMFHAM_00351	3.33e-35	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	cytokinin biosynthetic process
CODMFHAM_00353	5.01e-296	femA	2.3.2.17	-	V	ko:K11694	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	protein involved in methicillin resistance
CODMFHAM_00354	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CODMFHAM_00355	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
CODMFHAM_00356	6.87e-115	pacL	-	-	P	-	-	-	cation transport ATPase
CODMFHAM_00357	2.4e-256	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
CODMFHAM_00358	6.59e-285	malY	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
CODMFHAM_00360	1.49e-12	sacB	2.4.1.10, 2.4.1.9	GH68	G	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	Belongs to the glycosyl hydrolase 68 family
CODMFHAM_00361	1.06e-145	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CODMFHAM_00362	5.33e-135	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
CODMFHAM_00363	3.89e-96	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
CODMFHAM_00364	6.15e-62	ylbG	-	-	S	-	-	-	UPF0298 protein
CODMFHAM_00365	2.65e-269	livJ	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
CODMFHAM_00366	8.19e-190	livH	-	-	E	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
CODMFHAM_00367	6.36e-182	livM	-	-	E	ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
CODMFHAM_00368	3.96e-177	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
CODMFHAM_00369	8.89e-156	livF	-	-	E	ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
CODMFHAM_00370	3.29e-90	acuB	-	-	S	ko:K04767	-	ko00000	IMP dehydrogenase activity
CODMFHAM_00371	1.25e-56	acuB	-	-	S	ko:K04767	-	ko00000	IMP dehydrogenase activity
CODMFHAM_00372	2.63e-214	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
CODMFHAM_00373	3.86e-143	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
CODMFHAM_00374	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CODMFHAM_00375	1.02e-158	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
CODMFHAM_00376	1.88e-119	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CODMFHAM_00380	9.95e-215	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
CODMFHAM_00381	1.5e-139	-	-	-	S	-	-	-	Domain of unknown function (DUF1803)
CODMFHAM_00382	9.83e-133	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
CODMFHAM_00383	7.99e-179	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
CODMFHAM_00384	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CODMFHAM_00385	2.65e-245	asnA	6.3.1.1	-	E	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
CODMFHAM_00386	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
CODMFHAM_00387	3.43e-148	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
CODMFHAM_00388	4.99e-180	phaB	5.3.3.14, 5.3.3.18	-	I	ko:K15866,ko:K18474	ko00061,ko00360,ko01120,map00061,map00360,map01120	ko00000,ko00001,ko01000,ko01004	Belongs to the enoyl-CoA hydratase isomerase family
CODMFHAM_00389	2.67e-96	XK27_02735	-	-	K	-	-	-	Transcriptional regulator, MarR family
CODMFHAM_00390	7.66e-224	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CODMFHAM_00391	2.12e-40	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CODMFHAM_00392	1.31e-220	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	2-Nitropropane dioxygenase
CODMFHAM_00393	3.32e-211	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
CODMFHAM_00394	8.26e-165	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
CODMFHAM_00395	2.6e-297	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
CODMFHAM_00396	2.48e-87	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
CODMFHAM_00397	1.19e-93	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
CODMFHAM_00398	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
CODMFHAM_00399	2.95e-205	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CODMFHAM_00400	1.09e-175	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
CODMFHAM_00401	2.44e-137	-	-	-	L	ko:K07497	-	ko00000	COG2801 Transposase and inactivated derivatives
CODMFHAM_00402	2.54e-51	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00403	2.01e-90	rfbP	-	-	M	-	-	-	Bacterial sugar transferase
CODMFHAM_00404	2.25e-95	-	-	-	M	-	-	-	Oligosaccharide biosynthesis protein Alg14 like
CODMFHAM_00405	2.25e-54	-	-	-	S	-	-	-	Glycosyltransferase family 28 C-terminal domain
CODMFHAM_00406	2.03e-91	-	-	-	M	-	-	-	Glycosyltransferase sugar-binding region containing DXD motif
CODMFHAM_00407	1.64e-39	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00408	4.26e-288	rny	-	-	D	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
CODMFHAM_00409	8.72e-111	-	-	-	L	ko:K07485	-	ko00000	Transposase
CODMFHAM_00410	1.12e-164	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	transcriptional
CODMFHAM_00411	1.85e-211	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
CODMFHAM_00412	7.24e-151	-	2.7.1.202	-	GT	ko:K02768,ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
CODMFHAM_00413	3.01e-174	fruA	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
CODMFHAM_00414	1.53e-63	fruA	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
CODMFHAM_00415	0.0	gor	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CODMFHAM_00416	9.28e-311	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
CODMFHAM_00418	1.8e-271	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
CODMFHAM_00419	2.11e-290	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CODMFHAM_00420	0.0	gtf1	-	-	M	-	-	-	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
CODMFHAM_00421	0.0	gtf2	-	-	M	-	-	-	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
CODMFHAM_00422	1.13e-37	-	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	acetyltransferase
CODMFHAM_00423	1.99e-64	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
CODMFHAM_00424	1.55e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
CODMFHAM_00425	2.2e-158	ydaF_2	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CODMFHAM_00426	2.63e-82	WQ51_03320	-	-	S	-	-	-	cog cog4835
CODMFHAM_00427	1.56e-77	-	-	-	S	-	-	-	EDD domain protein, DegV family
CODMFHAM_00428	7.24e-99	degV	-	-	T	-	-	-	EDD domain protein, DegV family
CODMFHAM_00429	6.34e-179	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
CODMFHAM_00430	1.59e-287	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
CODMFHAM_00431	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00432	1.12e-27	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
CODMFHAM_00433	3.98e-90	-	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Nudix family
CODMFHAM_00434	2.64e-56	-	-	-	F	-	-	-	AdP-ribose pyrophosphatase
CODMFHAM_00435	9.81e-104	nadR	-	-	H	-	-	-	adenylyltransferase
CODMFHAM_00436	3.11e-110	nadR	-	-	H	-	-	-	adenylyltransferase
CODMFHAM_00437	0.0	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
CODMFHAM_00438	2.73e-92	def_1	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
CODMFHAM_00439	5.15e-100	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CODMFHAM_00440	0.0	lmrA1	-	-	V	ko:K02021,ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00441	3.75e-120	lmrA2	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00442	5.18e-268	lmrA2	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00443	7.57e-57	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
CODMFHAM_00444	1.86e-157	sptS	-	-	T	-	-	-	Histidine kinase
CODMFHAM_00445	1.38e-168	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
CODMFHAM_00446	6.76e-119	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
CODMFHAM_00447	1.6e-204	yitL	-	-	S	ko:K00243	-	ko00000	Protein conserved in bacteria
CODMFHAM_00448	3.3e-47	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
CODMFHAM_00449	3.9e-59	pcsB	-	-	S	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain
CODMFHAM_00450	6.98e-84	sip	-	-	M	-	-	-	LysM domain protein
CODMFHAM_00451	4.56e-244	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
CODMFHAM_00455	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CODMFHAM_00456	1.6e-214	-	-	-	K	-	-	-	transcriptional regulator (lysR family)
CODMFHAM_00457	2.71e-237	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
CODMFHAM_00458	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
CODMFHAM_00459	2.39e-164	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-Methyltransferase
CODMFHAM_00460	3.11e-235	prsA	3.1.3.16, 5.2.1.8	-	O	ko:K01802,ko:K03769,ko:K07533,ko:K20074	-	ko00000,ko01000,ko01009,ko03110	peptidyl-prolyl cis-trans isomerase activity
CODMFHAM_00461	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CODMFHAM_00462	6.56e-30	-	-	-	M	-	-	-	GBS Bsp-like repeat
CODMFHAM_00463	1.2e-130	-	-	-	M	-	-	-	GBS Bsp-like repeat
CODMFHAM_00464	5.45e-85	-	3.4.17.14, 3.5.1.28	-	NU	ko:K01448,ko:K02395,ko:K07260	ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036	amidase activity
CODMFHAM_00465	1.7e-172	-	3.4.17.14, 3.5.1.28	-	NU	ko:K01448,ko:K02395,ko:K07260	ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036	amidase activity
CODMFHAM_00466	3.29e-189	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
CODMFHAM_00467	1.73e-291	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	mutations do not affect methionine salvage in vivo however
CODMFHAM_00468	8.21e-245	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CODMFHAM_00469	1.15e-282	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CODMFHAM_00470	6.28e-165	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
CODMFHAM_00471	4.59e-62	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
CODMFHAM_00472	2.32e-169	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
CODMFHAM_00473	1.87e-177	icaB	-	-	G	-	-	-	deacetylase
CODMFHAM_00474	1.47e-303	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
CODMFHAM_00475	4.31e-197	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
CODMFHAM_00476	1.04e-191	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	Transporter
CODMFHAM_00478	2.62e-17	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
CODMFHAM_00479	2.66e-64	-	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CODMFHAM_00480	9.05e-61	-	-	-	S	-	-	-	FMN binding
CODMFHAM_00481	1.33e-71	-	2.3.1.128, 5.2.1.8	-	J	ko:K03768,ko:K03790	-	ko00000,ko01000,ko03009,ko03110	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CODMFHAM_00482	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
CODMFHAM_00483	5.88e-23	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CODMFHAM_00484	3.65e-159	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
CODMFHAM_00485	1.78e-102	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase F(0) sector subunit b
CODMFHAM_00486	3.66e-115	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CODMFHAM_00487	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CODMFHAM_00488	1.91e-203	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CODMFHAM_00489	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CODMFHAM_00490	6.23e-97	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
CODMFHAM_00491	3.51e-293	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
CODMFHAM_00492	7.86e-286	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CODMFHAM_00493	5.4e-174	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
CODMFHAM_00494	5.91e-143	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CODMFHAM_00495	2.73e-207	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	dna polymerase iii
CODMFHAM_00496	8.2e-177	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
CODMFHAM_00497	2.84e-73	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
CODMFHAM_00498	7.25e-206	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CODMFHAM_00499	6.27e-298	amt	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium Transporter
CODMFHAM_00500	3.27e-71	glnB	-	-	K	ko:K04751	ko02020,map02020	ko00000,ko00001	Belongs to the P(II) protein family
CODMFHAM_00501	2.28e-140	mur1	-	CBM50	NU	ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	mannosyl-glycoprotein
CODMFHAM_00502	3.07e-191	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
CODMFHAM_00503	7.89e-144	yjbB	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
CODMFHAM_00504	2.9e-279	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CODMFHAM_00505	5.94e-71	-	-	-	-	-	-	-	-
CODMFHAM_00506	1.6e-33	-	-	-	-	-	-	-	-
CODMFHAM_00507	7.32e-29	-	-	-	-	-	-	-	-
CODMFHAM_00508	4.82e-79	-	-	-	S	-	-	-	membrane
CODMFHAM_00509	1.01e-225	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
CODMFHAM_00510	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
CODMFHAM_00511	2.36e-51	ynzC	-	-	S	-	-	-	UPF0291 protein
CODMFHAM_00512	0.0	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	permease
CODMFHAM_00514	4.1e-30	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_00515	9.12e-190	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_00516	3.4e-177	ppiA	5.2.1.8	-	O	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	ko00000,ko00001,ko01000,ko03110,ko04147	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CODMFHAM_00521	1.93e-212	lysR	-	-	K	-	-	-	transcriptional regulator (lysR family)
CODMFHAM_00522	4.01e-100	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CODMFHAM_00523	4.9e-208	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
CODMFHAM_00524	2.72e-114	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CODMFHAM_00525	2.02e-288	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	uracil Permease
CODMFHAM_00526	3.37e-221	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
CODMFHAM_00527	1.53e-267	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	carbamoyl-phosphate synthetase glutamine chain
CODMFHAM_00528	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	carbamoyl-phosphate synthetase ammonia chain
CODMFHAM_00529	5.18e-172	-	-	-	S	-	-	-	Putative SAM-dependent methyltransferase
CODMFHAM_00530	7.57e-43	yknX	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CODMFHAM_00531	1.1e-46	-	-	-	V	-	-	-	efflux transmembrane transporter activity
CODMFHAM_00532	1.07e-44	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	efflux transmembrane transporter activity
CODMFHAM_00533	1.26e-32	ytrF	-	-	V	ko:K02004,ko:K16918	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	efflux transmembrane transporter activity
CODMFHAM_00534	3.14e-101	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CODMFHAM_00535	2.46e-69	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
CODMFHAM_00536	0.0	-	-	-	LV	-	-	-	TaqI-like C-terminal specificity domain
CODMFHAM_00537	9.65e-134	-	-	-	LV	-	-	-	TaqI-like C-terminal specificity domain
CODMFHAM_00539	5.48e-182	-	-	-	L	ko:K07497	-	ko00000	COG2801 Transposase and inactivated derivatives
CODMFHAM_00540	3.6e-51	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00541	0.0	msbA_1	-	-	V	ko:K18887	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_00542	0.0	lmrA	-	-	V	ko:K06147,ko:K18888	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_00543	2.38e-252	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CODMFHAM_00544	1.03e-163	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
CODMFHAM_00545	5.17e-287	hk02	-	-	T	-	-	-	signal transduction protein with a C-terminal ATPase domain
CODMFHAM_00546	3.51e-170	rr02	-	-	KT	-	-	-	response regulator
CODMFHAM_00547	1.96e-280	thiF	2.7.7.73	-	H	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
CODMFHAM_00548	2.86e-215	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
CODMFHAM_00549	1.79e-157	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
CODMFHAM_00550	3.93e-250	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
CODMFHAM_00551	4.86e-45	XK27_00085	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional
CODMFHAM_00553	9.44e-186	-	-	-	F	-	-	-	Phosphorylase superfamily
CODMFHAM_00554	5.99e-145	-	-	-	S	-	-	-	VIT family
CODMFHAM_00555	3.68e-170	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
CODMFHAM_00556	2.5e-109	hipO2	-	-	E	ko:K01436,ko:K21613	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CODMFHAM_00557	6.81e-148	hipO2	-	-	E	ko:K01436,ko:K21613	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CODMFHAM_00558	6.18e-23	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	alanine dehydrogenase activity
CODMFHAM_00559	2.16e-57	ald	1.4.1.1	-	C	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
CODMFHAM_00560	1.9e-316	merA	-	-	C	-	-	-	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CODMFHAM_00561	6.85e-123	-	-	-	J	ko:K09962	-	ko00000	protein conserved in bacteria
CODMFHAM_00562	1.14e-195	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
CODMFHAM_00563	9.29e-222	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
CODMFHAM_00564	2.78e-227	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GHMP kinases N terminal domain
CODMFHAM_00565	5.33e-243	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
CODMFHAM_00566	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CODMFHAM_00567	3.01e-125	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	AdP-ribose pyrophosphatase
CODMFHAM_00568	2.09e-41	-	-	-	-	-	-	-	-
CODMFHAM_00569	7.33e-152	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CODMFHAM_00571	9.15e-10	-	-	-	M	ko:K02460	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	domain protein
CODMFHAM_00572	1.31e-83	-	-	-	M	ko:K02460	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	domain protein
CODMFHAM_00573	1.21e-243	dgs	2.4.1.208	GT4	M	ko:K13677	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
CODMFHAM_00574	0.0	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
CODMFHAM_00575	5.47e-29	-	-	-	-	-	-	-	-
CODMFHAM_00576	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CODMFHAM_00577	3.37e-192	-	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
CODMFHAM_00578	3.9e-210	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
CODMFHAM_00579	3.47e-28	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
CODMFHAM_00580	3.94e-149	hly-III	-	-	K	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
CODMFHAM_00581	7.18e-297	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
CODMFHAM_00582	1.81e-278	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	synthase
CODMFHAM_00583	5.15e-214	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CODMFHAM_00584	8.53e-120	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CODMFHAM_00585	2.97e-30	-	-	-	-	-	-	-	-
CODMFHAM_00586	1.26e-287	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CODMFHAM_00587	6.75e-144	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
CODMFHAM_00588	1.72e-316	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
CODMFHAM_00589	5.61e-224	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	Homocysteine
CODMFHAM_00590	5.22e-41	-	-	-	S	-	-	-	Domain of unknown function (DUF1912)
CODMFHAM_00592	1.49e-138	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
CODMFHAM_00593	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CODMFHAM_00594	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
CODMFHAM_00595	1.75e-255	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
CODMFHAM_00596	3.44e-22	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
CODMFHAM_00599	4.12e-268	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein S1
CODMFHAM_00602	9.86e-38	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3862)
CODMFHAM_00603	5.3e-41	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3862)
CODMFHAM_00604	4.65e-71	-	-	-	M	-	-	-	Pfam SNARE associated Golgi protein
CODMFHAM_00605	6.61e-296	murN	-	-	V	ko:K12554	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	FemAB family
CODMFHAM_00606	8.6e-11	-	-	-	S	-	-	-	oxidoreductase
CODMFHAM_00607	3.79e-41	-	-	-	S	-	-	-	oxidoreductase
CODMFHAM_00608	4.77e-85	-	-	-	S	-	-	-	oxidoreductase
CODMFHAM_00609	4.51e-65	XK27_09445	-	-	S	-	-	-	Domain of unknown function (DUF1827)
CODMFHAM_00610	7.82e-111	XK27_09440	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
CODMFHAM_00611	0.0	clpE	-	-	O	ko:K03697	-	ko00000,ko03110	Belongs to the ClpA ClpB family
CODMFHAM_00612	3.3e-233	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CODMFHAM_00613	1.15e-47	ykuJ	-	-	S	-	-	-	protein conserved in bacteria
CODMFHAM_00614	3.24e-151	-	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CODMFHAM_00615	7.69e-170	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_00616	3.01e-102	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA domain protein
CODMFHAM_00617	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
CODMFHAM_00618	6.95e-12	-	-	-	-	-	-	-	-
CODMFHAM_00619	7.96e-45	yugF	-	-	I	-	-	-	carboxylic ester hydrolase activity
CODMFHAM_00620	4.86e-203	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CODMFHAM_00621	1.01e-191	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CODMFHAM_00622	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
CODMFHAM_00623	3.97e-143	-	-	-	L	ko:K07497	-	ko00000	integrase core domain
CODMFHAM_00624	1.52e-135	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CODMFHAM_00625	3.05e-58	licT	-	-	K	ko:K02538,ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
CODMFHAM_00626	1.21e-69	licT	-	-	K	ko:K02538,ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
CODMFHAM_00627	8.88e-112	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CODMFHAM_00628	1.16e-83	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
CODMFHAM_00629	1.16e-212	era	-	-	M	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CODMFHAM_00630	1.16e-199	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
CODMFHAM_00631	4.45e-136	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CODMFHAM_00632	1.06e-197	pmrA	-	-	EGP	ko:K08161	-	ko00000,ko02000	Major Facilitator
CODMFHAM_00633	1.06e-44	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
CODMFHAM_00634	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
CODMFHAM_00635	5.69e-105	smpB	-	-	O	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
CODMFHAM_00636	0.0	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CODMFHAM_00637	1.27e-83	yugI	-	-	J	ko:K07570	-	ko00000	RNA binding protein, contains ribosomal protein S1 domain
CODMFHAM_00638	8.17e-267	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Belongs to the peptidase M24B family
CODMFHAM_00639	1.34e-235	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	Catabolite control protein A
CODMFHAM_00640	2.03e-35	XK27_07735	-	-	S	-	-	-	YjbR
CODMFHAM_00641	5.04e-55	XK27_07735	-	-	S	-	-	-	YjbR
CODMFHAM_00642	4.03e-263	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
CODMFHAM_00643	1.03e-101	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
CODMFHAM_00644	5.04e-314	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
CODMFHAM_00645	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
CODMFHAM_00646	4.16e-280	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
CODMFHAM_00647	8.04e-158	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
CODMFHAM_00648	1.32e-205	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CODMFHAM_00649	6.87e-256	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CODMFHAM_00650	5.25e-279	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CODMFHAM_00651	1.84e-262	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
CODMFHAM_00652	1.48e-71	XK26_04240	-	-	S	-	-	-	Belongs to the UPF0342 family
CODMFHAM_00653	2.88e-221	hicD2	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
CODMFHAM_00654	6.18e-300	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
CODMFHAM_00655	2.28e-113	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CODMFHAM_00656	1.63e-195	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
CODMFHAM_00657	0.0	msrR	-	-	K	-	-	-	Transcriptional regulator
CODMFHAM_00658	1.73e-179	ydiA	-	-	P	ko:K03304,ko:K11041	ko05150,map05150	ko00000,ko00001,ko02000,ko02042	C4-dicarboxylate transporter malic acid transport protein
CODMFHAM_00659	3.16e-232	-	-	-	I	-	-	-	acyl-CoA dehydrogenase
CODMFHAM_00660	7.4e-126	mip	-	-	S	-	-	-	hydroperoxide reductase activity
CODMFHAM_00661	0.0	rumA	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CODMFHAM_00662	3.89e-131	-	-	-	-	-	-	-	-
CODMFHAM_00663	5.76e-27	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
CODMFHAM_00664	2.24e-53	dam	2.1.1.72	-	L	ko:K07318	-	ko00000,ko01000,ko02048	D12 class N6 adenine-specific DNA methyltransferase
CODMFHAM_00665	1.39e-35	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
CODMFHAM_00666	1.2e-15	-	-	-	-	-	-	-	-
CODMFHAM_00667	2.14e-108	-	-	-	-	-	-	-	-
CODMFHAM_00668	0.0	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CODMFHAM_00669	6.55e-221	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_00670	8.44e-71	-	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_00671	6.13e-236	-	-	-	S	-	-	-	CRISPR-associated protein Csn2 subfamily St
CODMFHAM_00672	1.62e-189	XK27_03010	-	-	S	ko:K08986	-	ko00000	TIGR03943 family
CODMFHAM_00673	1.8e-196	XK27_03015	-	-	S	ko:K07089	-	ko00000	permease
CODMFHAM_00675	0.0	tex	-	-	K	ko:K06959	-	ko00000	Transcriptional accessory protein
CODMFHAM_00676	1.55e-110	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
CODMFHAM_00677	5.93e-55	WQ51_05770	-	-	KT	-	-	-	PspC domain
CODMFHAM_00678	8.23e-218	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CODMFHAM_00679	6.15e-190	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CODMFHAM_00680	1.07e-25	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CODMFHAM_00681	2.64e-88	ytxH	-	-	S	-	-	-	General stress protein
CODMFHAM_00683	4.3e-229	yrrN	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
CODMFHAM_00684	0.0	yrrO	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
CODMFHAM_00685	4.42e-112	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	biotin synthase
CODMFHAM_00687	2.97e-45	XK27_12190	-	-	S	-	-	-	protein conserved in bacteria
CODMFHAM_00688	6.38e-298	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
CODMFHAM_00690	3.85e-88	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
CODMFHAM_00691	0.0	-	-	-	L	-	-	-	helicase
CODMFHAM_00692	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
CODMFHAM_00693	3.33e-27	-	-	-	M	-	-	-	LysM domain
CODMFHAM_00694	1.96e-167	-	-	-	M	-	-	-	LysM domain
CODMFHAM_00695	1.73e-28	-	-	-	-	-	-	-	-
CODMFHAM_00696	3.26e-224	-	-	-	S	ko:K07025	-	ko00000	hydrolase
CODMFHAM_00697	3.06e-151	pgm	-	-	G	-	-	-	Phosphoglycerate mutase
CODMFHAM_00698	2.49e-105	-	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CODMFHAM_00699	6.96e-197	-	3.5.1.28	-	M	ko:K01447,ko:K07273	-	ko00000,ko01000	Glycosyl hydrolase, family 25
CODMFHAM_00700	1.14e-35	-	-	-	P	-	-	-	Hemerythrin HHE cation binding domain protein
CODMFHAM_00701	6.94e-146	-	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CODMFHAM_00702	1.82e-11	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
CODMFHAM_00703	3.31e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
CODMFHAM_00704	1.49e-50	sdh	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
CODMFHAM_00705	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CODMFHAM_00706	4.04e-27	-	-	-	-	-	-	-	-
CODMFHAM_00707	4.39e-151	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
CODMFHAM_00708	4.22e-136	-	-	-	-	-	-	-	-
CODMFHAM_00709	3.26e-174	-	-	-	S	-	-	-	Protein conserved in bacteria
CODMFHAM_00710	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
CODMFHAM_00711	4.72e-20	-	-	-	S	-	-	-	double-stranded DNA endodeoxyribonuclease activity
CODMFHAM_00712	5.29e-238	spd	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
CODMFHAM_00713	1.47e-118	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
CODMFHAM_00714	8.47e-190	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
CODMFHAM_00715	6.06e-97	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	Psort location CytoplasmicMembrane, score
CODMFHAM_00716	2.18e-73	-	-	-	S	-	-	-	Domain of unknown function (DUF4430)
CODMFHAM_00717	0.0	ppc	4.1.1.31	-	H	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CODMFHAM_00718	6.66e-237	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
CODMFHAM_00719	6.73e-145	sodA	1.15.1.1	-	C	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
CODMFHAM_00720	1.01e-296	-	-	-	V	-	-	-	D-alanyl-D-alanine carboxypeptidase
CODMFHAM_00721	1.34e-151	pppA	3.4.23.43	-	NOU	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	Bacterial Peptidase A24 N-terminal domain
CODMFHAM_00722	5.49e-119	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
CODMFHAM_00723	3.37e-104	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
CODMFHAM_00724	7.8e-38	yqgQ	-	-	S	-	-	-	protein conserved in bacteria
CODMFHAM_00725	2.49e-230	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
CODMFHAM_00726	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
CODMFHAM_00727	2.68e-12	-	-	-	S	-	-	-	Protein of unknown function (DUF3165)
CODMFHAM_00728	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CODMFHAM_00729	5.46e-258	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CODMFHAM_00730	1.1e-241	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
CODMFHAM_00731	0.0	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
CODMFHAM_00732	7.57e-303	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CODMFHAM_00733	2.3e-158	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CODMFHAM_00734	5.99e-124	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	cell septum assembly
CODMFHAM_00735	1.8e-46	yggT	-	-	D	ko:K02221	-	ko00000,ko02044	integral membrane protein
CODMFHAM_00736	8.33e-185	ylmH	-	-	T	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	S4 RNA-binding domain
CODMFHAM_00737	3.44e-185	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division protein DivIVA
CODMFHAM_00738	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CODMFHAM_00739	7.86e-62	-	-	-	L	-	-	-	Transposase
CODMFHAM_00740	3.64e-13	-	-	-	-	-	-	-	-
CODMFHAM_00741	3.44e-196	mntH_2	-	-	P	-	-	-	Mn2 and Fe2 transporters of the NRAMP family
CODMFHAM_00742	3.3e-79	mntH_2	-	-	P	-	-	-	Mn2 and Fe2 transporters of the NRAMP family
CODMFHAM_00743	1.39e-61	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	50S ribosomal protein L31
CODMFHAM_00744	1.09e-223	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
CODMFHAM_00745	1.75e-226	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	domain protein
CODMFHAM_00746	1.11e-196	gst	-	-	O	ko:K11209	-	ko00000,ko01000	Glutathione S-transferase
CODMFHAM_00747	1.25e-237	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CODMFHAM_00748	2.55e-143	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
CODMFHAM_00749	9.23e-247	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CODMFHAM_00750	9.12e-199	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
CODMFHAM_00751	1.46e-141	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
CODMFHAM_00752	1.45e-297	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CODMFHAM_00753	3.52e-227	-	-	-	S	-	-	-	37-kD nucleoid-associated bacterial protein
CODMFHAM_00754	6.28e-137	pvaA	-	-	M	ko:K02395	-	ko00000,ko02035	lytic transglycosylase activity
CODMFHAM_00755	0.0	yfiB1	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00756	0.0	XK27_10035	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_00757	2.56e-14	-	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
CODMFHAM_00758	0.0	dltA	6.1.1.13	-	Q	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CODMFHAM_00759	1.03e-301	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Membrane protein involved in D-alanine export
CODMFHAM_00760	4.98e-48	dltC	6.1.1.13	-	IQ	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
CODMFHAM_00761	1.09e-311	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CODMFHAM_00762	5.61e-71	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00763	1.55e-101	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00764	0.0	-	3.6.3.2, 3.6.3.6, 3.6.3.8	-	P	ko:K01531,ko:K01535,ko:K01537	ko00190,map00190	ko00000,ko00001,ko01000	cation transport ATPase
CODMFHAM_00765	0.0	pabB	2.6.1.85, 4.1.3.38	-	EH	ko:K01665,ko:K03342,ko:K13950	ko00790,map00790	ko00000,ko00001,ko01000,ko01007	component I
CODMFHAM_00772	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	HsdM N-terminal domain
CODMFHAM_00773	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CODMFHAM_00775	1.48e-152	-	4.1.1.22	-	H	ko:K01590	ko00340,ko01100,ko01110,map00340,map01100,map01110	ko00000,ko00001,ko01000	Histidine carboxylase PI chain
CODMFHAM_00776	4.41e-211	arcD	-	-	E	ko:K03756,ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
CODMFHAM_00778	3.06e-27	-	-	-	L	-	-	-	RePlication protein
CODMFHAM_00779	3.92e-31	-	-	-	L	-	-	-	Replication protein
CODMFHAM_00783	0.0	-	-	-	S	ko:K06919	-	ko00000	DNA primase
CODMFHAM_00784	4.19e-151	-	-	-	KL	ko:K06919	-	ko00000	Phage plasmid primase P4 family
CODMFHAM_00785	8.98e-29	-	-	-	-	-	-	-	-
CODMFHAM_00789	1.1e-27	-	-	-	K	-	-	-	TRANSCRIPTIONal
CODMFHAM_00790	1.17e-13	-	-	-	K	-	-	-	Transcriptional
CODMFHAM_00791	2.19e-271	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CODMFHAM_00792	6.58e-116	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
CODMFHAM_00793	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CODMFHAM_00794	6.12e-179	metF	1.5.1.20	-	C	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	reductase
CODMFHAM_00795	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
CODMFHAM_00796	2.62e-121	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
CODMFHAM_00797	6.08e-120	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CODMFHAM_00798	1.56e-156	coaB	6.3.2.5	-	H	ko:K21977	ko00770,map00770	ko00000,ko00001,ko00002,ko01000	Phosphopantothenate-cysteine ligase
CODMFHAM_00799	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
CODMFHAM_00800	1.33e-151	ciaR	-	-	T	ko:K14983	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CODMFHAM_00801	4.29e-50	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_00802	5.1e-52	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_00803	1.8e-160	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_00804	1.98e-40	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	rRNA binding
CODMFHAM_00805	7.09e-222	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
CODMFHAM_00806	5.78e-139	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase small domain protein
CODMFHAM_00807	2.94e-34	pdp	2.4.2.2, 2.4.2.4	-	F	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	ko00000,ko00001,ko01000	phosphorylase activity
CODMFHAM_00808	1.78e-31	pdp	2.4.2.2, 2.4.2.4	-	F	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	ko00000,ko00001,ko01000	phosphorylase activity
CODMFHAM_00809	1.71e-125	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
CODMFHAM_00810	2.84e-29	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CODMFHAM_00811	4.43e-82	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CODMFHAM_00812	2.26e-86	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
CODMFHAM_00813	1.65e-243	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
CODMFHAM_00814	0.0	mglA	3.6.3.17	-	S	ko:K02056,ko:K06400	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
CODMFHAM_00815	7.56e-244	mglC	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
CODMFHAM_00816	1.48e-220	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
CODMFHAM_00817	3.2e-157	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
CODMFHAM_00818	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
CODMFHAM_00819	3.8e-106	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
CODMFHAM_00820	3.85e-279	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
CODMFHAM_00821	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
CODMFHAM_00823	1.84e-83	aldR	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	endoribonuclease L-PSP
CODMFHAM_00824	1.07e-158	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CODMFHAM_00825	3.49e-107	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
CODMFHAM_00826	1.06e-173	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
CODMFHAM_00827	4.7e-123	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
CODMFHAM_00828	5.88e-24	-	-	-	D	-	-	-	nuclear chromosome segregation
CODMFHAM_00829	6.3e-175	yejC	-	-	S	-	-	-	cyclic nucleotide-binding protein
CODMFHAM_00830	1.2e-208	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
CODMFHAM_00831	1.24e-231	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
CODMFHAM_00832	1.2e-207	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
CODMFHAM_00833	2.24e-132	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
CODMFHAM_00834	5.66e-55	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
CODMFHAM_00835	2.63e-44	-	-	-	K	-	-	-	Cold shock protein domain
CODMFHAM_00836	1.06e-56	cspA	-	-	K	ko:K03704	-	ko00000,ko03000	Cold-Shock Protein
CODMFHAM_00837	7.37e-236	-	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CODMFHAM_00839	1.8e-218	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
CODMFHAM_00840	1.45e-279	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
CODMFHAM_00841	2.53e-127	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	serine acetyltransferase
CODMFHAM_00842	3.2e-68	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
CODMFHAM_00843	3.66e-109	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
CODMFHAM_00844	4.85e-75	hsdS	2.1.1.72, 3.1.21.3	-	V	ko:K01154,ko:K07317	-	ko00000,ko01000,ko02048	type I restriction modification DNA specificity domain
CODMFHAM_00845	5.7e-146	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
CODMFHAM_00846	4.14e-22	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	Glucose uptake
CODMFHAM_00847	1.15e-165	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	Glucose uptake
CODMFHAM_00848	5.25e-08	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CODMFHAM_00849	1.07e-98	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	HsdM N-terminal domain
CODMFHAM_00850	3.84e-112	XK27_10720	-	-	D	-	-	-	peptidase activity
CODMFHAM_00851	0.0	adcA	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
CODMFHAM_00853	2.24e-219	yeiH	-	-	S	-	-	-	Membrane
CODMFHAM_00854	5.97e-149	-	-	CBM50	NU	ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	muramidase
CODMFHAM_00855	2.27e-27	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_00856	5.8e-94	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_00857	3.61e-213	cpsY	-	-	K	-	-	-	Transcriptional regulator
CODMFHAM_00858	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
CODMFHAM_00859	7.71e-77	phnA	-	-	P	ko:K06193	ko01120,map01120	ko00000	Alkylphosphonate utilization operon protein PhnA
CODMFHAM_00860	3.92e-134	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_00861	6.16e-145	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_00862	1.11e-202	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
CODMFHAM_00863	4.7e-179	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CODMFHAM_00864	2.18e-10	-	-	-	-	-	-	-	-
CODMFHAM_00865	2.51e-75	adhP	1.1.1.1	-	C	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
CODMFHAM_00866	7.49e-139	adhP	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
CODMFHAM_00868	6.8e-58	-	2.1.1.72	-	L	ko:K07316	-	ko00000,ko01000,ko02048	Adenine specific DNA methylase Mod
CODMFHAM_00869	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
CODMFHAM_00870	9.02e-163	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
CODMFHAM_00871	9e-72	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CODMFHAM_00872	0.0	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CODMFHAM_00873	5.65e-113	niaX	-	-	-	ko:K16788	-	ko00000,ko02000	-
CODMFHAM_00874	1.3e-116	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
CODMFHAM_00875	9.08e-166	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
CODMFHAM_00876	1.46e-203	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CODMFHAM_00877	4.11e-175	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CODMFHAM_00878	6.25e-216	-	-	-	GK	-	-	-	ROK family
CODMFHAM_00879	4.71e-202	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
CODMFHAM_00880	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CODMFHAM_00881	3.43e-197	-	-	-	S	-	-	-	TraX protein
CODMFHAM_00882	1.63e-154	spaR	-	-	KT	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CODMFHAM_00883	0.0	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
CODMFHAM_00884	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CODMFHAM_00885	1.99e-195	XK27_05470	-	-	E	-	-	-	Methionine synthase
CODMFHAM_00886	1.01e-99	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
CODMFHAM_00887	4.95e-63	pspE	-	-	P	ko:K03972	-	ko00000	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CODMFHAM_00888	1.68e-66	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	Acetoin reductase
CODMFHAM_00889	2.91e-58	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	Acetoin reductase
CODMFHAM_00891	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
CODMFHAM_00893	2.32e-93	dinF	-	-	V	-	-	-	Mate efflux family protein
CODMFHAM_00894	8.47e-51	dinF	-	-	V	-	-	-	Mate efflux family protein
CODMFHAM_00895	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
CODMFHAM_00896	0.000353	-	-	-	S	-	-	-	TraX protein
CODMFHAM_00897	7.61e-147	-	-	-	S	-	-	-	TraX protein
CODMFHAM_00898	5.84e-123	thiJ	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1 family
CODMFHAM_00899	4.35e-163	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
CODMFHAM_00900	2.11e-223	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
CODMFHAM_00901	1.62e-232	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_00902	1.69e-71	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_00903	9.82e-152	-	-	-	S	-	-	-	Pfam:DUF2276
CODMFHAM_00904	0.0	csm1	-	-	S	ko:K07016	-	ko00000,ko02048	CRISPR-associated protein Csm1 family
CODMFHAM_00905	3.35e-70	-	-	-	L	ko:K19138	-	ko00000,ko02048	Pfam:DUF310
CODMFHAM_00906	9.77e-152	csm3	-	-	L	ko:K09002	-	ko00000,ko02048	RAMP superfamily
CODMFHAM_00907	1.04e-215	csm4	-	-	L	ko:K19139	-	ko00000,ko02048	CRISPR-associated RAMP protein, Csm4 family
CODMFHAM_00908	2.51e-259	csm5	-	-	L	ko:K19140	-	ko00000,ko02048	CRISPR-associated RAMP protein, Csm5 family
CODMFHAM_00909	1.79e-18	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
CODMFHAM_00910	3.63e-94	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
CODMFHAM_00911	1.02e-163	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
CODMFHAM_00912	4.34e-145	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CODMFHAM_00913	3.66e-11	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	amidase activity
CODMFHAM_00914	3.14e-63	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
CODMFHAM_00915	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	POT family
CODMFHAM_00916	3.36e-72	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
CODMFHAM_00917	4.29e-41	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
CODMFHAM_00918	9.73e-125	yckB	-	-	ET	ko:K02030,ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
CODMFHAM_00919	1.25e-16	yckB	-	-	ET	ko:K02030,ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
CODMFHAM_00920	7.45e-31	yecS	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	amino acid transport
CODMFHAM_00921	1.07e-09	sasH	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00922	7.44e-291	sasH	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00923	2.94e-71	sasH	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_00924	1.39e-136	yfiF3	-	-	K	-	-	-	sequence-specific DNA binding
CODMFHAM_00925	2.47e-28	bglC	-	-	K	-	-	-	Transcriptional regulator
CODMFHAM_00926	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CODMFHAM_00927	3.36e-305	agcS	-	-	E	ko:K03310	-	ko00000	(Alanine) symporter
CODMFHAM_00928	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
CODMFHAM_00929	2.95e-307	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	o-acetylhomoserine
CODMFHAM_00930	5.48e-79	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
CODMFHAM_00931	1.66e-111	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CODMFHAM_00932	4.7e-143	hsdS2	-	-	V	-	-	-	Type I restriction modification DNA specificity domain
CODMFHAM_00933	7.29e-284	XK27_04775	-	-	S	ko:K09155	-	ko00000	hemerythrin HHE cation binding domain
CODMFHAM_00934	2.43e-194	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CODMFHAM_00935	1.96e-222	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
CODMFHAM_00936	4.35e-94	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
CODMFHAM_00937	1.7e-59	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
CODMFHAM_00938	5.9e-184	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
CODMFHAM_00939	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
CODMFHAM_00940	2.07e-202	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	phosphate
CODMFHAM_00941	4.63e-201	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
CODMFHAM_00942	5.04e-200	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	phosphate transport system permease
CODMFHAM_00943	5.27e-193	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CODMFHAM_00944	1.24e-179	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CODMFHAM_00945	2.58e-146	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
CODMFHAM_00946	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
CODMFHAM_00947	1.54e-248	xerS	-	-	D	ko:K04763	-	ko00000,ko03036	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
CODMFHAM_00949	7.54e-240	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
CODMFHAM_00952	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
CODMFHAM_00953	3.67e-56	malQ	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
CODMFHAM_00954	6.71e-307	malQ	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
CODMFHAM_00955	1.43e-228	malR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
CODMFHAM_00956	3.39e-24	malX	-	-	G	ko:K15770	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
CODMFHAM_00957	9.69e-25	malX	-	-	G	ko:K02027,ko:K15770	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	maltose binding
CODMFHAM_00958	8.36e-66	malX	-	-	G	ko:K02027,ko:K15770	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	maltose binding
CODMFHAM_00959	1.65e-138	malF	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_00960	4.79e-34	tatA	-	-	U	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	protein secretion
CODMFHAM_00961	5.26e-156	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CODMFHAM_00962	0.0	ywbL	-	-	P	ko:K07243	-	ko00000,ko02000	COG0672 High-affinity Fe2 Pb2 permease
CODMFHAM_00963	2.59e-297	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	peroxidase
CODMFHAM_00964	8.71e-200	ycdO	-	-	P	ko:K07224	-	ko00000,ko02000	periplasmic lipoprotein involved in iron transport
CODMFHAM_00965	2.96e-154	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type enterochelin transport system, periplasmic component
CODMFHAM_00966	4.03e-63	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type enterochelin transport system, periplasmic component
CODMFHAM_00967	1.18e-172	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_00968	9.01e-214	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CODMFHAM_00969	1.67e-209	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CODMFHAM_00970	4.63e-162	pulA2	3.2.1.1, 3.2.1.41	CBM48,GH13	G	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
CODMFHAM_00971	8.97e-71	pulA2	3.2.1.1, 3.2.1.41	CBM48,GH13	G	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
CODMFHAM_00972	5.12e-250	pulA2	3.2.1.1, 3.2.1.41	CBM48,GH13	G	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
CODMFHAM_00973	9.47e-108	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	GBS Bsp-like repeat
CODMFHAM_00974	1.84e-117	-	3.5.1.28	-	S	ko:K01448,ko:K02395,ko:K21471	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036	dextransucrase activity
CODMFHAM_00975	3.79e-215	-	3.5.1.28	-	S	ko:K01448,ko:K02395,ko:K21471	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036	dextransucrase activity
CODMFHAM_00976	1.1e-28	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	GBS Bsp-like repeat
CODMFHAM_00977	0.0	lpdA	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
CODMFHAM_00978	4.3e-238	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
CODMFHAM_00979	3.38e-232	acoB	1.2.4.1	-	C	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
CODMFHAM_00980	1.07e-236	acoA	1.2.4.1	-	C	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
CODMFHAM_00981	5.86e-53	-	-	-	P	-	-	-	membrane protein (DUF2207)
CODMFHAM_00982	1.34e-109	-	-	-	S	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
CODMFHAM_00983	4.01e-298	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
CODMFHAM_00984	8.14e-163	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CODMFHAM_00985	3.15e-276	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CODMFHAM_00986	2.2e-22	dacA1	3.4.16.4	-	M	ko:K01286	-	ko00000,ko01000	Belongs to the peptidase S11 family
CODMFHAM_00987	1.67e-21	dacA1	3.4.16.4	-	M	ko:K01286	-	ko00000,ko01000	Belongs to the peptidase S11 family
CODMFHAM_00988	2.62e-97	dacA1	3.4.16.4	-	M	ko:K01286	-	ko00000,ko01000	Belongs to the peptidase S11 family
CODMFHAM_00989	1.3e-201	-	-	-	S	-	-	-	Phospholipase, patatin family
CODMFHAM_00990	1.34e-135	-	-	-	E	-	-	-	Lysophospholipase L1 and related esterases
CODMFHAM_00991	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	unusual protein kinase
CODMFHAM_00992	3.34e-52	-	-	-	S	-	-	-	granule-associated protein
CODMFHAM_00993	9.85e-49	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
CODMFHAM_00994	4.58e-171	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
CODMFHAM_00995	1.74e-22	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
CODMFHAM_00996	1.68e-254	XK27_12525	-	-	S	-	-	-	hmm pf01594
CODMFHAM_00997	1.29e-114	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
CODMFHAM_00998	3.51e-77	supH	3.1.3.102, 3.1.3.104	-	Q	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	phosphatase activity
CODMFHAM_00999	1.72e-18	supH	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
CODMFHAM_01000	2.84e-123	-	-	-	V	-	-	-	VanZ like family
CODMFHAM_01001	6.19e-131	-	-	-	L	ko:K07485	-	ko00000	Transposase
CODMFHAM_01002	5.07e-122	-	-	-	S	-	-	-	Glycosyltransferase like family 2
CODMFHAM_01003	3.82e-52	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain
CODMFHAM_01004	1.81e-105	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain
CODMFHAM_01005	2.96e-22	-	-	-	L	ko:K07483	-	ko00000	Transposase
CODMFHAM_01006	7.79e-80	-	-	-	L	ko:K07498	-	ko00000	DDE domain
CODMFHAM_01007	1.22e-29	rgpAc	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	group 1 family protein
CODMFHAM_01008	0.0	cpsE	-	-	M	-	-	-	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
CODMFHAM_01009	1.7e-154	cpsD	-	-	D	-	-	-	COG0489 ATPases involved in chromosome partitioning
CODMFHAM_01010	2.25e-146	capA	-	-	M	-	-	-	biosynthesis protein
CODMFHAM_01011	4.66e-175	cpsB	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	Capsular polysaccharide biosynthesis protein
CODMFHAM_01012	0.0	cps4A	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
CODMFHAM_01013	1.28e-164	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	purine nucleoside phosphorylase
CODMFHAM_01015	2.42e-137	gat	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	glutamine amidotransferase
CODMFHAM_01016	4.94e-69	clcA2	-	-	P	-	-	-	chloride
CODMFHAM_01017	4.15e-191	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CODMFHAM_01018	1.56e-299	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CODMFHAM_01019	7.14e-157	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CODMFHAM_01021	5.99e-11	-	-	-	V	-	-	-	Glucan-binding protein C
CODMFHAM_01022	1.32e-143	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
CODMFHAM_01023	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Dipeptidase
CODMFHAM_01024	2.78e-37	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
CODMFHAM_01025	9.78e-112	XK27_03610	-	-	K	-	-	-	Gnat family
CODMFHAM_01026	8.06e-33	-	-	-	L	ko:K07491	-	ko00000	Transposase
CODMFHAM_01027	1.82e-73	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CODMFHAM_01028	1.66e-38	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
CODMFHAM_01029	1.56e-115	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CODMFHAM_01030	1.44e-156	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
CODMFHAM_01031	4.72e-50	XK27_09115	-	-	M	-	-	-	LysM domain
CODMFHAM_01032	1.12e-119	ebsA	-	-	S	-	-	-	Family of unknown function (DUF5322)
CODMFHAM_01033	4.14e-297	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
CODMFHAM_01034	1.13e-126	sipC	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
CODMFHAM_01035	1.34e-285	XK27_05225	-	-	G	-	-	-	COG0457 FOG TPR repeat
CODMFHAM_01036	2.32e-236	XK27_05220	-	-	S	-	-	-	permease
CODMFHAM_01037	2.04e-119	mutX	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NTP pyrophosphohydrolases including oxidative damage repair enzymes
CODMFHAM_01038	4.01e-209	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
CODMFHAM_01039	7.31e-160	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
CODMFHAM_01040	5.35e-232	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CODMFHAM_01041	8.68e-263	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CODMFHAM_01042	9.04e-233	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
CODMFHAM_01043	6.58e-173	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
CODMFHAM_01044	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	cation transport ATPase
CODMFHAM_01045	1.19e-89	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
CODMFHAM_01046	5.11e-64	XK27_00115	-	-	K	-	-	-	Acetyltransferase GNAT family
CODMFHAM_01047	1.62e-188	XK27_00835	-	-	S	-	-	-	hydrolases of the HAD superfamily
CODMFHAM_01048	1.28e-294	femX	2.3.2.10, 2.3.2.16	-	V	ko:K05363,ko:K11693	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	protein involved in methicillin resistance
CODMFHAM_01049	1.77e-197	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Metal-dependent hydrolases of the beta-lactamase superfamily I
CODMFHAM_01050	2.23e-314	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_01051	2.05e-165	yycF	-	-	KT	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CODMFHAM_01052	5.21e-178	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01053	4.65e-192	peb1A	-	-	ET	ko:K02030,ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type amino acid transport signal transduction systems, periplasmic component domain
CODMFHAM_01054	3.95e-157	XK27_07620	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_01055	1.43e-142	-	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
CODMFHAM_01056	2.41e-202	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
CODMFHAM_01057	4.09e-35	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
CODMFHAM_01058	1.23e-296	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CODMFHAM_01060	3.65e-251	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
CODMFHAM_01062	1.44e-266	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CODMFHAM_01063	1.08e-219	birA	6.3.4.15	-	HK	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
CODMFHAM_01065	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CODMFHAM_01066	9.17e-116	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
CODMFHAM_01067	1.56e-211	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CODMFHAM_01068	1.9e-27	WQ51_02665	-	-	S	-	-	-	Protein of unknown function (DUF3042)
CODMFHAM_01071	5.73e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
CODMFHAM_01072	1.68e-276	-	-	-	P	-	-	-	chloride
CODMFHAM_01073	1.27e-55	pheA	1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5	-	E	ko:K00661,ko:K04092,ko:K04093,ko:K04516,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase
CODMFHAM_01074	0.0	eriC	-	-	P	ko:K03281	-	ko00000	Chloride transporter, ClC family
CODMFHAM_01075	4.07e-97	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
CODMFHAM_01077	2.2e-162	XK27_08875	-	-	O	-	-	-	Zinc-dependent metalloprotease
CODMFHAM_01078	1.84e-194	estA	-	CE1	S	ko:K03930	-	ko00000,ko01000	Putative esterase
CODMFHAM_01079	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CODMFHAM_01080	2.68e-174	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01081	1.86e-188	XK27_08840	-	-	S	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
CODMFHAM_01082	9.72e-229	-	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter substrate binding protein
CODMFHAM_01083	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
CODMFHAM_01084	1.04e-239	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
CODMFHAM_01085	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
CODMFHAM_01086	1.99e-194	XK27_00020	-	-	J	-	-	-	Belongs to the SUA5 family
CODMFHAM_01087	2.76e-146	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CODMFHAM_01088	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CODMFHAM_01089	1.64e-57	ysdA	-	-	L	-	-	-	Membrane
CODMFHAM_01090	5.65e-228	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
CODMFHAM_01091	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CODMFHAM_01092	2.22e-14	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CODMFHAM_01093	7.19e-168	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CODMFHAM_01094	2.31e-230	pyrD	1.3.5.2, 1.3.98.1	-	F	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dihydroorotate to orotate
CODMFHAM_01096	1.54e-52	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
CODMFHAM_01097	4.93e-123	ypmS	-	-	S	-	-	-	Protein conserved in bacteria
CODMFHAM_01098	4.43e-187	ypmR	-	-	E	-	-	-	lipolytic protein G-D-S-L family
CODMFHAM_01099	3.39e-190	WQ51_01275	-	-	S	-	-	-	DegV family
CODMFHAM_01100	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
CODMFHAM_01101	4.21e-95	argR	-	-	K	ko:K03402	-	ko00000,ko03000	arginine binding
CODMFHAM_01102	1.64e-202	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
CODMFHAM_01103	1.64e-203	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
CODMFHAM_01104	1.72e-40	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease VII activity
CODMFHAM_01105	1.83e-313	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
CODMFHAM_01108	1.55e-153	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CODMFHAM_01109	5.22e-162	dnaD	-	-	-	ko:K02086	-	ko00000	-
CODMFHAM_01110	2.81e-232	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CODMFHAM_01111	6.44e-122	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CODMFHAM_01112	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease recj
CODMFHAM_01113	1.28e-178	yqjQ	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
CODMFHAM_01114	1.27e-221	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
CODMFHAM_01115	6.65e-152	XK27_05445	-	-	G	-	-	-	UDPglucose--hexose-1-phosphate uridylyltransferase
CODMFHAM_01116	1.36e-284	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CODMFHAM_01117	0.0	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
CODMFHAM_01118	5.16e-66	hisE	3.5.4.19, 3.6.1.31, 5.3.1.16	-	E	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosyl-ATP diphosphatase activity
CODMFHAM_01119	7.31e-81	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CODMFHAM_01120	1.73e-170	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
CODMFHAM_01121	1.48e-160	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CODMFHAM_01122	1.58e-139	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CODMFHAM_01123	1.36e-136	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
CODMFHAM_01124	1.62e-295	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CODMFHAM_01125	1.9e-147	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
CODMFHAM_01126	6.21e-59	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CODMFHAM_01127	2.96e-151	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CODMFHAM_01128	6.07e-252	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CODMFHAM_01130	3.94e-35	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain protein
CODMFHAM_01131	3.61e-65	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_01132	5.01e-14	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_01133	1.16e-48	-	-	-	L	ko:K07483	-	ko00000	Transposase
CODMFHAM_01134	1.38e-41	XK27_08085	-	-	-	-	-	-	-
CODMFHAM_01135	1.38e-115	XK27_08080	-	-	G	-	-	-	Exopolysaccharide biosynthesis protein
CODMFHAM_01136	3.95e-17	XK27_08080	-	-	G	-	-	-	Exopolysaccharide biosynthesis protein
CODMFHAM_01137	6.9e-181	hisJ	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphatase and related hydrolases of the PHP family
CODMFHAM_01138	4.03e-157	-	-	-	S	-	-	-	tigr01906
CODMFHAM_01139	2.81e-183	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
CODMFHAM_01140	7.79e-185	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
CODMFHAM_01141	2.3e-277	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
CODMFHAM_01144	3.31e-264	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
CODMFHAM_01145	4.07e-144	rmlC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
CODMFHAM_01146	7.83e-206	rfbA	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CODMFHAM_01147	2.51e-263	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	oxidoreductase
CODMFHAM_01148	7.32e-168	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	Mediates zinc uptake. May also transport other divalent cations
CODMFHAM_01149	2.32e-189	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CODMFHAM_01150	3.68e-160	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
CODMFHAM_01151	2.02e-92	mesH	-	-	S	-	-	-	GtrA-like protein
CODMFHAM_01152	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CODMFHAM_01153	2.43e-216	ybbR	-	-	S	-	-	-	Protein conserved in bacteria
CODMFHAM_01154	2.71e-159	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CODMFHAM_01155	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Mur ligase, middle domain protein
CODMFHAM_01156	1.02e-192	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
CODMFHAM_01157	0.0	mprF	2.3.2.3	-	J	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CODMFHAM_01158	4.3e-169	-	1.11.1.10	-	S	ko:K00433	-	ko00000,ko01000	Alpha beta hydrolase
CODMFHAM_01159	1.38e-18	MA20_06245	-	-	S	-	-	-	yiaA/B two helix domain
CODMFHAM_01161	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	abc transporter atp-binding protein
CODMFHAM_01162	2.24e-148	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
CODMFHAM_01163	6.73e-245	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
CODMFHAM_01164	2.02e-39	-	6.3.2.2, 6.3.2.4	-	F	ko:K01919,ko:K01921	ko00270,ko00473,ko00480,ko00550,ko01100,ko01502,map00270,map00473,map00480,map00550,map01100,map01502	ko00000,ko00001,ko00002,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
CODMFHAM_01165	0.0	gapN	1.2.1.9	-	C	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
CODMFHAM_01166	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CODMFHAM_01167	3.31e-52	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein Hpr
CODMFHAM_01168	1.2e-281	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate dehydrogenase
CODMFHAM_01169	1.22e-270	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
CODMFHAM_01170	0.0	acnA	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CODMFHAM_01171	3.36e-46	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
CODMFHAM_01172	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CODMFHAM_01173	8.44e-237	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CODMFHAM_01175	2.69e-73	-	-	-	L	-	-	-	Transposase (IS116 IS110 IS902 family)
CODMFHAM_01176	2.47e-81	-	-	-	L	-	-	-	Transposase (IS116 IS110 IS902 family)
CODMFHAM_01177	8e-210	ypuA	-	-	S	-	-	-	secreted protein
CODMFHAM_01178	2.89e-71	ywkD	-	-	E	ko:K08234	-	ko00000	COG0346 LactoylglutaTHIone lyase and related lyases
CODMFHAM_01179	2.97e-167	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase (surface protein transpeptidase)
CODMFHAM_01180	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CODMFHAM_01181	2.06e-232	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
CODMFHAM_01182	0.0	noxE	-	-	P	-	-	-	NADH oxidase
CODMFHAM_01183	0.0	yheS_1	-	-	S	-	-	-	abc transporter atp-binding protein
CODMFHAM_01184	1.19e-58	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
CODMFHAM_01185	1.59e-15	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
CODMFHAM_01186	7.71e-109	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Belongs to the pyridoxine kinase family
CODMFHAM_01187	1.38e-55	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Belongs to the pyridoxine kinase family
CODMFHAM_01188	1.46e-112	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
CODMFHAM_01190	1.21e-303	ycxD	-	-	K	-	-	-	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
CODMFHAM_01191	4.59e-75	nrdD_1	1.1.98.6, 1.17.4.1	-	F	ko:K00525,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Ribonucleoside-triphosphate reductase
CODMFHAM_01194	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CODMFHAM_01195	4.18e-118	XK27_03150	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CODMFHAM_01196	5.02e-250	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CODMFHAM_01197	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
CODMFHAM_01198	1.39e-160	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
CODMFHAM_01199	2.2e-223	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CODMFHAM_01200	8.33e-254	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CODMFHAM_01201	7.55e-120	pat	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	acetyltransferase
CODMFHAM_01203	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CODMFHAM_01204	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
CODMFHAM_01205	3.96e-45	yfnB	3.8.1.2	-	E	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	hydrolase
CODMFHAM_01206	5.29e-27	yfnB	3.8.1.2	-	E	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	hydrolase
CODMFHAM_01207	2.31e-157	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
CODMFHAM_01208	9.64e-191	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
CODMFHAM_01209	5.43e-184	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
CODMFHAM_01210	3.09e-45	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	transport system, permease component
CODMFHAM_01211	9.08e-57	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	transport system, permease component
CODMFHAM_01212	6.7e-55	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	transport system, permease component
CODMFHAM_01213	4.88e-133	desR	-	-	K	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CODMFHAM_01214	1.2e-245	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_01215	8.66e-172	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
CODMFHAM_01216	6.62e-200	XK27_09825	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01219	1.11e-212	yocS	-	-	S	ko:K03453	-	ko00000	Transporter
CODMFHAM_01220	1.32e-95	-	-	-	F	-	-	-	cytidine deaminase activity
CODMFHAM_01221	3.04e-07	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transporter
CODMFHAM_01222	3.95e-147	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transporter
CODMFHAM_01223	9.01e-198	XK27_09825	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01226	9.31e-120	-	-	-	S	ko:K06940	-	ko00000	Fe-S-cluster oxidoreductase
CODMFHAM_01227	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
CODMFHAM_01228	1.36e-69	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
CODMFHAM_01229	3.5e-170	yxdL	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
CODMFHAM_01230	4.75e-220	-	-	-	T	-	-	-	Histidine kinase
CODMFHAM_01231	2.49e-157	graR	-	-	KT	ko:K19082	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
CODMFHAM_01232	4.09e-99	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
CODMFHAM_01233	2.62e-07	pbuX	-	-	F	ko:K16169	-	ko00000,ko02000	xanthine permease
CODMFHAM_01234	4.62e-96	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
CODMFHAM_01235	9.36e-60	pbuX	-	-	F	ko:K16169	-	ko00000,ko02000	Permease family
CODMFHAM_01236	1.26e-45	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
CODMFHAM_01237	1.85e-316	norM	-	-	V	ko:K03327	-	ko00000,ko02000	Multidrug efflux pump
CODMFHAM_01238	6.71e-240	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CODMFHAM_01239	1.41e-108	yxeM	-	-	ET	ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
CODMFHAM_01240	1.9e-250	-	4.3.2.2, 5.5.1.2	-	F	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase
CODMFHAM_01241	2.66e-118	yxeO	-	-	E	ko:K16963	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01242	8.13e-93	yxeN	-	-	P	ko:K10009,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_01243	1.13e-74	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
CODMFHAM_01244	2.28e-140	-	-	-	S	-	-	-	MmgE/PrpD family
CODMFHAM_01245	2.11e-187	ykrV3	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	mutations do not affect methionine salvage in vivo however
CODMFHAM_01246	4.06e-52	-	-	-	C	ko:K08317	-	ko00000,ko01000	glycerol dehydrogenase
CODMFHAM_01247	1.07e-63	-	-	-	C	ko:K08317	-	ko00000,ko01000	glycerol dehydrogenase
CODMFHAM_01249	3.98e-231	hipO2	-	-	E	ko:K01436,ko:K21613	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
CODMFHAM_01250	2.32e-298	brnQ	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
CODMFHAM_01251	6.42e-86	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
CODMFHAM_01252	5.58e-76	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
CODMFHAM_01253	3.31e-35	csbD	-	-	K	-	-	-	CsbD-like
CODMFHAM_01254	3.24e-294	yfnA	-	-	E	ko:K03294	-	ko00000	amino acid
CODMFHAM_01255	8.72e-95	-	-	-	S	-	-	-	dextransucrase activity
CODMFHAM_01256	1.2e-147	-	-	-	S	-	-	-	dextransucrase activity
CODMFHAM_01257	8.27e-175	-	-	-	S	-	-	-	dextransucrase activity
CODMFHAM_01258	5.49e-41	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain protein
CODMFHAM_01261	1.81e-173	tcyC2	-	-	E	ko:K10010,ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01262	2.02e-148	-	-	-	P	ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, permease protein
CODMFHAM_01263	6.18e-144	-	-	-	P	ko:K16958	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_01264	1.71e-204	-	-	-	ET	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
CODMFHAM_01265	1.63e-215	-	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen decarboxylase (URO-D)
CODMFHAM_01266	7.97e-108	gpo	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
CODMFHAM_01267	3.84e-54	-	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
CODMFHAM_01268	9.33e-31	-	-	-	P	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
CODMFHAM_01269	1.28e-47	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01270	9.93e-87	-	-	-	K	-	-	-	WHG domain
CODMFHAM_01271	1.39e-188	ydhF	-	-	S	-	-	-	Aldo keto reductase
CODMFHAM_01272	2.43e-09	ydhF	-	-	S	-	-	-	Aldo keto reductase
CODMFHAM_01273	8.8e-138	XK27_02070	-	-	S	ko:K07078	-	ko00000	nitroreductase
CODMFHAM_01274	2.1e-87	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
CODMFHAM_01275	4.92e-99	ywnA_2	-	-	K	-	-	-	Transcriptional regulator
CODMFHAM_01276	3.86e-190	-	-	-	E	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
CODMFHAM_01277	2.79e-293	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
CODMFHAM_01278	4.95e-144	ydgI	-	-	C	-	-	-	Nitroreductase
CODMFHAM_01279	5.24e-121	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
CODMFHAM_01280	1.84e-202	yvgN	-	-	C	-	-	-	reductase
CODMFHAM_01281	8.86e-125	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
CODMFHAM_01282	4.79e-66	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
CODMFHAM_01283	0.0	XK27_07020	-	-	S	-	-	-	Belongs to the UPF0371 family
CODMFHAM_01285	7.53e-49	BP1961	-	-	P	-	-	-	nitric oxide dioxygenase activity
CODMFHAM_01286	7.28e-70	saeR	-	-	K	ko:K10682	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
CODMFHAM_01287	1.78e-84	-	-	-	S	-	-	-	Signal peptide protein, YSIRK family
CODMFHAM_01289	6.59e-76	-	-	-	-	-	-	-	-
CODMFHAM_01290	0.0	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CODMFHAM_01291	2.23e-96	-	-	-	-	-	-	-	-
CODMFHAM_01292	7.71e-14	-	-	-	IQ	-	-	-	PFAM AMP-dependent synthetase and ligase
CODMFHAM_01293	4.88e-140	-	-	-	E	-	-	-	LysE type translocator
CODMFHAM_01294	1.96e-12	-	-	-	-	-	-	-	-
CODMFHAM_01295	0.0	-	-	-	M	-	-	-	family 8
CODMFHAM_01297	1.24e-234	cps1C	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
CODMFHAM_01300	7.98e-105	-	-	-	L	-	-	-	Transposase and inactivated derivatives
CODMFHAM_01301	3.52e-58	-	-	-	L	ko:K07483	-	ko00000	COG2963 Transposase and inactivated derivatives
CODMFHAM_01302	3.86e-34	-	-	-	-	-	-	-	-
CODMFHAM_01303	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	ATPase involved in DNA repair
CODMFHAM_01304	9.25e-293	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
CODMFHAM_01305	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	-beta-galactosidase
CODMFHAM_01306	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	transporter
CODMFHAM_01307	9.77e-257	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
CODMFHAM_01308	6.03e-248	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
CODMFHAM_01309	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDPglucose--hexose-1-phosphate uridylyltransferase
CODMFHAM_01310	3.7e-279	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CODMFHAM_01311	1.63e-235	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
CODMFHAM_01312	1.7e-13	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain protein
CODMFHAM_01313	1.18e-34	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_01314	1.44e-232	-	-	-	M	ko:K08643	-	ko00000,ko01000,ko01002	translation initiation factor activity
CODMFHAM_01315	8.6e-52	zmpB	-	-	M	ko:K08643	-	ko00000,ko01000,ko01002	M26 IgA1-specific Metallo-endopeptidase C-terminal region
CODMFHAM_01316	3.89e-25	zmpB	-	-	M	ko:K08643	-	ko00000,ko01000,ko01002	M26 IgA1-specific Metallo-endopeptidase C-terminal region
CODMFHAM_01317	4.6e-126	ndvA	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
CODMFHAM_01318	1.49e-54	-	-	-	V	ko:K18996,ko:K19171	-	ko00000,ko02048,ko03032	(ABC) transporter
CODMFHAM_01319	0.0	gshF	6.3.2.2	-	H	ko:K01919,ko:K16786,ko:K16787	ko00270,ko00480,ko01100,ko02010,map00270,map00480,map01100,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the glutamate--cysteine ligase type 1 family
CODMFHAM_01320	1.28e-94	-	-	-	L	-	-	-	Transposase
CODMFHAM_01321	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
CODMFHAM_01322	5.74e-241	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
CODMFHAM_01323	1.15e-173	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
CODMFHAM_01324	6.44e-122	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CODMFHAM_01327	8.07e-148	vraR	-	-	K	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
CODMFHAM_01328	1.12e-224	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
CODMFHAM_01329	4.61e-156	yvqF	-	-	KT	ko:K11622	ko02020,map02020	ko00000,ko00001	membrane
CODMFHAM_01330	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
CODMFHAM_01331	7.75e-170	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
CODMFHAM_01332	5.64e-315	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CODMFHAM_01333	1.55e-223	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CODMFHAM_01334	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CODMFHAM_01335	6.79e-62	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-directed 5'-3' RNA polymerase activity
CODMFHAM_01336	1.24e-144	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
CODMFHAM_01337	2.3e-311	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CODMFHAM_01338	1.34e-193	XK27_02985	-	-	S	-	-	-	overlaps another CDS with the same product name
CODMFHAM_01339	2.22e-188	-	-	-	S	-	-	-	overlaps another CDS with the same product name
CODMFHAM_01340	3.45e-83	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional
CODMFHAM_01341	1.23e-160	skfE	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01342	2.73e-172	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPase activity
CODMFHAM_01343	5.04e-50	amiF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_01344	1.18e-60	amiF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
CODMFHAM_01345	6.54e-30	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family'
CODMFHAM_01346	3.41e-277	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
CODMFHAM_01347	6.7e-110	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
CODMFHAM_01348	1.67e-37	-	-	-	L	ko:K07497	-	ko00000	transposition
CODMFHAM_01349	1.11e-30	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_01350	6.14e-58	-	-	-	L	ko:K07483	-	ko00000	transposase activity
CODMFHAM_01351	1.15e-233	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
CODMFHAM_01352	6.56e-221	yjbO	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
CODMFHAM_01353	1.19e-197	nadK	2.7.1.23	-	H	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CODMFHAM_01354	1.13e-156	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	Gtp pyrophosphokinase
CODMFHAM_01355	5.5e-134	yjbK	-	-	S	-	-	-	Adenylate cyclase
CODMFHAM_01356	2.07e-226	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CODMFHAM_01357	1.12e-264	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
CODMFHAM_01358	1.77e-78	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
CODMFHAM_01359	5.62e-155	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
CODMFHAM_01360	0.0	rgpF	-	-	M	ko:K07272	-	ko00000,ko01000,ko01003,ko01005	Rhamnan synthesis protein F
CODMFHAM_01361	5.39e-251	rgpE	-	GT2	M	ko:K12998	-	ko00000,ko01000,ko01003,ko01005	COG0463 Glycosyltransferases involved in cell wall biogenesis
CODMFHAM_01362	2.09e-287	rgpD	3.6.3.40	-	P	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
CODMFHAM_01363	4.54e-183	rgpC	-	-	GM	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
CODMFHAM_01364	5.23e-230	rgpB	-	GT2	M	ko:K12997	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
CODMFHAM_01365	1.9e-284	rgpA	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	Domain of unknown function (DUF1972)
CODMFHAM_01366	1.62e-171	-	-	-	S	-	-	-	Predicted membrane protein (DUF2142)
CODMFHAM_01367	3.16e-235	tagF	2.7.8.12	-	M	ko:K09809,ko:K19046	-	ko00000,ko01000,ko02048	Glycosyl transferase, family 2
CODMFHAM_01368	1.15e-280	rgpX3	-	-	S	-	-	-	polysaccharide biosynthetic process
CODMFHAM_01369	3.81e-64	-	-	-	S	ko:K09153	-	ko00000	Uncharacterized conserved protein (DUF2304)
CODMFHAM_01370	1.69e-161	-	-	-	S	-	-	-	Glycosyl transferase family 2
CODMFHAM_01371	1.1e-206	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
CODMFHAM_01372	1.69e-154	-	-	-	-	-	-	-	-
CODMFHAM_01373	6.39e-31	-	-	-	-	-	-	-	-
CODMFHAM_01374	7.94e-220	yfdH	-	GT2	M	ko:K12999,ko:K20534	-	ko00000,ko01000,ko01003,ko01005,ko02000	COG0463, glycosyltransferases involved in cell wall biogenesis
CODMFHAM_01375	1.98e-73	yitW	-	-	K	-	-	-	metal-sulfur cluster biosynthetic enzyme
CODMFHAM_01376	3.03e-257	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
CODMFHAM_01377	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
CODMFHAM_01378	1.62e-62	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
CODMFHAM_01379	4.11e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
CODMFHAM_01380	9.99e-176	artP	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
CODMFHAM_01381	1.36e-267	arcT	-	-	E	-	-	-	Aminotransferase
CODMFHAM_01382	1.31e-176	XK27_04395	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter
CODMFHAM_01383	5.56e-184	XK27_04395	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
CODMFHAM_01384	2.15e-109	XK27_04400	3.6.1.55	-	F	ko:K03574,ko:K12944	-	ko00000,ko01000,ko03400	Nudix family
CODMFHAM_01385	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
CODMFHAM_01387	6.65e-72	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
CODMFHAM_01388	1.27e-39	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family protein
CODMFHAM_01389	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type amino acid transport signal transduction systems periplasmic component domain
CODMFHAM_01390	7.15e-176	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01391	1.84e-24	XK27_00735	-	-	-	-	-	-	-
CODMFHAM_01392	1.9e-315	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CODMFHAM_01393	8.41e-11	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
CODMFHAM_01394	1.5e-171	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
CODMFHAM_01397	1.25e-85	-	-	-	Q	ko:K02614	ko00360,map00360	ko00000,ko00001,ko01000	protein possibly involved in aromatic compounds catabolism
CODMFHAM_01398	8.22e-51	ycaO	-	-	O	ko:K06889,ko:K07397,ko:K09136	-	ko00000,ko03009	OsmC-like protein
CODMFHAM_01400	1.33e-196	-	-	-	EG	-	-	-	Permeases of the drug metabolite transporter (DMT) superfamily
CODMFHAM_01401	1.09e-143	csn2	-	-	S	ko:K19137	-	ko00000,ko02048	CRISPR-associated protein (Cas_Csn2)
CODMFHAM_01402	4.16e-73	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_01403	1.72e-209	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CODMFHAM_01404	0.0	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CODMFHAM_01405	1.23e-249	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	(ABC) transporter
CODMFHAM_01406	1.78e-68	-	-	-	K	-	-	-	Acetyltransferase GNAT Family
CODMFHAM_01407	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
CODMFHAM_01409	1.76e-147	serB	3.1.3.3	-	E	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01009	phosphoserine phosphatase
CODMFHAM_01410	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CODMFHAM_01411	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CODMFHAM_01412	6.21e-141	-	-	-	S	-	-	-	IA, variant 1
CODMFHAM_01413	2.27e-151	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	effector of murein hydrolase
CODMFHAM_01414	3.88e-75	lrgA	-	-	S	ko:K06518	-	ko00000,ko02000	Effector of murein hydrolase LrgA
CODMFHAM_01416	3.55e-79	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
CODMFHAM_01417	4.23e-73	ogt	2.1.1.63, 3.2.2.20	-	L	ko:K00567,ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	methylated-DNA-[protein]-cysteine S-methyltransferase activity
CODMFHAM_01418	1.76e-279	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CODMFHAM_01419	5.63e-136	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
CODMFHAM_01420	3.61e-267	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CODMFHAM_01421	2.27e-37	-	-	-	GK	-	-	-	ROK family
CODMFHAM_01422	1.12e-67	-	-	-	GK	-	-	-	ROK family
CODMFHAM_01423	1.61e-93	gloA	4.4.1.5	-	E	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Lactoylglutathione lyase
CODMFHAM_01424	1.57e-75	XK27_08050	-	-	O	-	-	-	stress-induced mitochondrial fusion
CODMFHAM_01425	8.14e-47	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	HflC and HflK could regulate a protease
CODMFHAM_01426	4.81e-25	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	HflC and HflK could regulate a protease
CODMFHAM_01427	2.71e-260	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	spermidine putrescine ABC transporter
CODMFHAM_01428	5.13e-171	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type spermidine putrescine transport system, permease component II
CODMFHAM_01429	2e-179	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type spermidine putrescine transport system, permease component I
CODMFHAM_01430	5.6e-272	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
CODMFHAM_01431	4.74e-218	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
CODMFHAM_01432	7.94e-114	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CODMFHAM_01433	2.48e-80	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CODMFHAM_01434	0.0	amy	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
CODMFHAM_01435	3.69e-188	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CODMFHAM_01436	1.17e-129	folE	3.5.4.16	-	F	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	gtp cyclohydrolase
CODMFHAM_01437	0.0	ydaO	-	-	E	-	-	-	amino acid
CODMFHAM_01438	2.74e-304	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
CODMFHAM_01439	9.09e-50	ylqC	-	-	L	ko:K06960	-	ko00000	Belongs to the UPF0109 family
CODMFHAM_01440	1.87e-57	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
CODMFHAM_01441	6.55e-220	tehB	2.1.1.265	-	Q	ko:K16868	-	ko00000,ko01000	Methyltransferase
CODMFHAM_01442	9.9e-202	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
CODMFHAM_01443	1.22e-97	-	-	-	S	-	-	-	QueT transporter
CODMFHAM_01444	4.27e-11	-	-	-	L	-	-	-	Transposase DDE domain
CODMFHAM_01445	2.45e-114	-	-	-	L	-	-	-	Transposase DDE domain
CODMFHAM_01446	3.17e-236	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
CODMFHAM_01447	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CODMFHAM_01448	4.63e-110	ccl	-	-	S	-	-	-	cog cog4708
CODMFHAM_01449	1.26e-206	rbn	-	-	E	ko:K07058	-	ko00000	Belongs to the UPF0761 family
CODMFHAM_01450	2.86e-211	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
CODMFHAM_01451	1.29e-296	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
CODMFHAM_01452	5.58e-126	XK27_07830	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase GNAT Family
CODMFHAM_01453	2.48e-294	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CODMFHAM_01454	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
CODMFHAM_01455	3.3e-120	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
CODMFHAM_01456	8.31e-138	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
CODMFHAM_01457	1.76e-183	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
CODMFHAM_01458	1.68e-115	nodB3	-	-	G	-	-	-	polysaccharide deacetylase
CODMFHAM_01459	3.95e-56	nodB3	-	-	G	-	-	-	polysaccharide deacetylase
CODMFHAM_01460	2.62e-34	-	-	-	L	ko:K07485	-	ko00000	Transposase
CODMFHAM_01461	2.59e-176	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase
CODMFHAM_01462	1.68e-55	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
CODMFHAM_01463	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
CODMFHAM_01464	6.14e-205	corA	-	-	P	-	-	-	CorA-like protein
CODMFHAM_01465	1.07e-82	yjqA	-	-	S	-	-	-	Bacterial PH domain
CODMFHAM_01466	6.49e-129	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter
CODMFHAM_01467	2.62e-203	rgg	-	-	K	-	-	-	Transcriptional activator, Rgg GadR MutR family
CODMFHAM_01468	6.74e-151	yjbB	-	-	G	-	-	-	Permeases of the major facilitator superfamily
CODMFHAM_01469	1.12e-59	yjbB	-	-	G	-	-	-	Permeases of the major facilitator superfamily
CODMFHAM_01470	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CODMFHAM_01471	1.15e-155	ywaF	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
CODMFHAM_01472	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
CODMFHAM_01476	1.34e-199	cjaA	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
CODMFHAM_01477	6.72e-173	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01478	6.63e-127	glnP9	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_01479	4.58e-246	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
CODMFHAM_01480	9.48e-43	copZ	-	-	P	-	-	-	Heavy metal-associated domain protein
CODMFHAM_01481	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
CODMFHAM_01482	7.11e-96	copY	-	-	K	-	-	-	negative regulation of transcription, DNA-templated
CODMFHAM_01483	1.01e-182	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
CODMFHAM_01484	2.88e-290	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CODMFHAM_01485	3.9e-131	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the TrpF family
CODMFHAM_01486	2.77e-173	trpC	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
CODMFHAM_01487	2.58e-229	trpD	2.4.2.18, 4.1.3.27	-	F	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CODMFHAM_01488	1.43e-135	trpG	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	anthranilate
CODMFHAM_01489	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CODMFHAM_01490	2.1e-56	MA20_20425	2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5	-	E	ko:K00800,ko:K03785,ko:K04092,ko:K04782	ko00400,ko01053,ko01100,ko01110,ko01130,ko01230,map00400,map01053,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase
CODMFHAM_01491	1.25e-74	-	-	-	-	-	-	-	-
CODMFHAM_01492	0.0	ctpE	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
CODMFHAM_01493	3.83e-35	-	-	-	-	-	-	-	-
CODMFHAM_01494	1.07e-58	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CODMFHAM_01495	5.39e-62	-	-	-	L	-	-	-	transposase activity
CODMFHAM_01496	4.87e-122	-	-	-	K	-	-	-	transcriptional regulator, MerR family
CODMFHAM_01497	5.56e-16	-	-	-	K	-	-	-	transcriptional regulator, MerR family
CODMFHAM_01498	1.2e-131	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
CODMFHAM_01499	1.41e-80	WQ51_02910	-	-	S	-	-	-	Protein of unknown function, DUF536
CODMFHAM_01500	1.12e-75	XK27_02560	-	-	S	-	-	-	cog cog2151
CODMFHAM_01501	0.0	ilvD	4.2.1.9	-	E	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the IlvD Edd family
CODMFHAM_01502	3.35e-289	ytfP	-	-	S	ko:K07007	-	ko00000	Flavoprotein
CODMFHAM_01504	1.46e-154	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
CODMFHAM_01505	3.45e-196	ytmP	-	-	M	-	-	-	Phosphotransferase
CODMFHAM_01506	4.97e-228	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
CODMFHAM_01507	1.68e-168	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01508	1.02e-93	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
CODMFHAM_01509	5.24e-11	-	-	-	-	-	-	-	-
CODMFHAM_01510	1.1e-139	-	-	-	-	-	-	-	-
CODMFHAM_01512	0.0	clpL	-	-	O	ko:K04086	-	ko00000,ko03110	ATP-dependent Clp protease ATP-binding subunit
CODMFHAM_01513	2.07e-261	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
CODMFHAM_01514	5.61e-179	XK27_06665	-	-	Q	-	-	-	Methyltransferase domain protein
CODMFHAM_01515	9.81e-77	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
CODMFHAM_01516	2.35e-138	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
CODMFHAM_01517	4.53e-152	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CODMFHAM_01518	1.59e-65	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
CODMFHAM_01519	2.78e-275	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
CODMFHAM_01520	1.84e-127	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
CODMFHAM_01521	4.95e-196	-	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
CODMFHAM_01522	1.02e-85	-	-	-	-	-	-	-	-
CODMFHAM_01523	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CODMFHAM_01524	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
CODMFHAM_01525	7.49e-64	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CODMFHAM_01526	0.0	ascB	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
CODMFHAM_01527	6.58e-124	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CODMFHAM_01528	8.06e-198	metQ	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
CODMFHAM_01529	2.48e-129	pncA	-	-	Q	ko:K16788	-	ko00000,ko02000	isochorismatase
CODMFHAM_01530	6.34e-182	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CODMFHAM_01531	4.4e-295	aspC	2.6.1.2, 2.6.1.66	-	E	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
CODMFHAM_01532	1.03e-96	XK27_03180	-	-	T	-	-	-	universal stress protein
CODMFHAM_01534	6.98e-202	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CODMFHAM_01535	4.07e-304	hlyX	-	-	S	ko:K03699	-	ko00000,ko02042	COG1253 Hemolysins and related proteins containing CBS domains
CODMFHAM_01536	1.29e-185	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01537	0.0	nhaP1	-	-	P	ko:K03316	-	ko00000	NhaP-type Na H and K H antiporters
CODMFHAM_01539	1.82e-126	mraW1	-	-	J	-	-	-	(SAM)-dependent
CODMFHAM_01540	2.51e-235	ytqA	-	-	S	ko:K07139	-	ko00000	radical SAM protein
CODMFHAM_01541	5.38e-250	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
CODMFHAM_01542	6.51e-114	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CODMFHAM_01543	2.58e-120	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
CODMFHAM_01544	2.77e-219	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
CODMFHAM_01545	7.33e-14	-	-	-	S	-	-	-	Protein of unknown function (DUF4059)
CODMFHAM_01546	2.28e-168	tcyN	3.6.3.21	-	E	ko:K02028,ko:K10010,ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
CODMFHAM_01547	2.42e-206	yxeN	-	-	P	ko:K02029,ko:K16959,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
CODMFHAM_01548	2.46e-193	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC-type amino acid transport signal transduction systems, periplasmic component domain
CODMFHAM_01550	5.24e-257	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CODMFHAM_01551	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	formate acetyltransferase'
CODMFHAM_01552	4.61e-82	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	carbonic anhydrase
CODMFHAM_01553	1.55e-110	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
CODMFHAM_01554	2.87e-62	hsdS_1	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	type I restriction modification DNA specificity domain
CODMFHAM_01555	3.7e-42	-	-	-	D	-	-	-	nuclear chromosome segregation
CODMFHAM_01556	6.56e-43	-	-	-	L	ko:K04763	-	ko00000,ko03036	DNA integration
CODMFHAM_01557	1.5e-159	XK27_05540	-	-	S	-	-	-	Gram-negative-bacterium-type cell wall biogenesis
CODMFHAM_01558	2.14e-160	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	transport system, permease component
CODMFHAM_01559	1.24e-152	ybbL	-	-	S	ko:K02068	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01560	2.19e-39	-	-	-	-	-	-	-	-
CODMFHAM_01561	4.14e-235	-	-	-	V	-	-	-	COG1680 Beta-lactamase class C and other penicillin binding proteins
CODMFHAM_01562	2.59e-61	cppA	-	-	E	-	-	-	CppA N-terminal
CODMFHAM_01563	6.47e-97	cppA	-	-	E	-	-	-	CppA N-terminal
CODMFHAM_01564	3.74e-38	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
CODMFHAM_01565	7.59e-212	gla	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
CODMFHAM_01566	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
CODMFHAM_01569	1.31e-63	spiA	-	-	K	ko:K18831	-	ko00000,ko02048,ko03000	sequence-specific DNA binding
CODMFHAM_01570	1.11e-210	blpT	-	-	-	-	-	-	-
CODMFHAM_01574	0.000546	-	-	-	-	-	-	-	-
CODMFHAM_01575	7.44e-24	-	-	-	S	-	-	-	Bacteriocin class II with double-glycine leader peptide
CODMFHAM_01576	1.63e-92	agrA	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
CODMFHAM_01577	1.11e-58	agrA	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
CODMFHAM_01578	1.03e-301	blpH	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
CODMFHAM_01580	2.39e-309	mesE	-	-	M	ko:K20345	ko02024,map02024	ko00000,ko00001,ko02000	Transport protein ComB
CODMFHAM_01581	0.0	comA	-	-	V	ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
CODMFHAM_01582	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01583	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01585	8.09e-122	XK27_09885	-	-	V	-	-	-	Glycopeptide antibiotics resistance protein
CODMFHAM_01586	1.36e-286	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
CODMFHAM_01587	3.68e-134	yutD	-	-	J	-	-	-	protein conserved in bacteria
CODMFHAM_01588	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
CODMFHAM_01590	5.56e-304	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
CODMFHAM_01591	1.28e-232	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CODMFHAM_01592	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
CODMFHAM_01593	3.89e-62	ftsL	-	-	D	-	-	-	cell division protein FtsL
CODMFHAM_01594	1.54e-221	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
CODMFHAM_01595	2.14e-110	-	-	-	-	-	-	-	-
CODMFHAM_01596	2.96e-87	-	-	-	-	-	-	-	-
CODMFHAM_01597	2.53e-26	-	-	-	J	-	-	-	Protein of unknown function (DUF805)
CODMFHAM_01598	1.18e-21	-	-	-	D	-	-	-	nuclear chromosome segregation
CODMFHAM_01599	5.79e-288	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CODMFHAM_01600	2.47e-182	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CODMFHAM_01601	0.0	XK27_00765	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
CODMFHAM_01602	1.61e-166	ecsA_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
CODMFHAM_01603	4.54e-157	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
CODMFHAM_01604	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
CODMFHAM_01605	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CODMFHAM_01606	2.54e-84	-	-	-	S	-	-	-	membrane
CODMFHAM_01607	3.34e-14	XK27_02470	-	-	K	-	-	-	LytTr DNA-binding domain protein
CODMFHAM_01608	7.41e-82	-	-	-	KT	-	-	-	response to antibiotic
CODMFHAM_01609	4.24e-21	-	-	-	KT	-	-	-	response to antibiotic
CODMFHAM_01610	3.36e-112	yebC	-	-	M	-	-	-	Membrane
CODMFHAM_01611	1.77e-24	yebC	-	-	M	-	-	-	Membrane
CODMFHAM_01612	0.0	-	-	-	S	-	-	-	hydrolases of the HAD superfamily
CODMFHAM_01613	6.64e-222	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
CODMFHAM_01614	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CODMFHAM_01615	5.74e-245	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CODMFHAM_01616	1.75e-80	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
CODMFHAM_01617	1.01e-251	aroG	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CODMFHAM_01618	2.03e-251	aroH	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CODMFHAM_01619	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
CODMFHAM_01621	1.78e-240	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
CODMFHAM_01622	4.37e-34	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	Fructokinase
CODMFHAM_01623	6.78e-173	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	Fructokinase
CODMFHAM_01624	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
CODMFHAM_01625	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
CODMFHAM_01626	2.12e-226	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	Transcriptional
CODMFHAM_01627	2.67e-96	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CODMFHAM_01628	9.01e-81	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	protein conserved in bacteria
CODMFHAM_01629	1.73e-126	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CODMFHAM_01630	5.83e-109	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
CODMFHAM_01631	1.14e-253	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Belongs to the peptidase M24B family
CODMFHAM_01633	8.53e-55	-	-	-	V	ko:K01990,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	'abc transporter, ATP-binding protein
CODMFHAM_01636	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CODMFHAM_01637	6.01e-218	corA	-	-	P	ko:K03284	-	ko00000,ko02000	COG0598 Mg2 and Co2 transporters
CODMFHAM_01638	5.06e-160	-	-	-	S	-	-	-	Pfam PF06570
CODMFHAM_01640	2.03e-47	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CODMFHAM_01641	2.07e-118	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CODMFHAM_01642	3.11e-62	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
CODMFHAM_01643	2.5e-51	XK27_05745	-	-	-	-	-	-	-
CODMFHAM_01644	9.59e-293	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific adenine glycosylase
CODMFHAM_01648	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CODMFHAM_01649	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
CODMFHAM_01650	3.39e-121	cvpA	-	-	S	ko:K03558	-	ko00000	toxin biosynthetic process
CODMFHAM_01651	5.78e-19	-	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CODMFHAM_01652	2.72e-205	rnhC	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CODMFHAM_01653	3.19e-146	spi	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
CODMFHAM_01654	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
CODMFHAM_01655	1.91e-63	azlD	-	-	E	-	-	-	branched-chain amino acid
CODMFHAM_01656	8.81e-149	XK27_12120	-	-	E	-	-	-	AzlC protein
CODMFHAM_01657	1.64e-238	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CODMFHAM_01658	1.54e-96	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
CODMFHAM_01659	5.62e-155	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214, inactive homolog of metal-dependent proteases
CODMFHAM_01660	6.45e-45	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
CODMFHAM_01661	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CODMFHAM_01662	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
CODMFHAM_01663	3.2e-83	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	Transcriptional regulator
CODMFHAM_01664	1.53e-113	-	-	-	S	-	-	-	Fusaric acid resistance protein-like
CODMFHAM_01665	9.88e-17	-	-	-	-	-	-	-	-
CODMFHAM_01666	5.03e-43	-	-	-	-	-	-	-	-
CODMFHAM_01667	1.35e-282	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
CODMFHAM_01668	1.23e-56	-	-	-	L	ko:K07491	-	ko00000	Transposase
CODMFHAM_01669	1.57e-114	-	-	-	L	ko:K07497	-	ko00000	Transposase and inactivated derivatives
CODMFHAM_01670	9.42e-242	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
CODMFHAM_01671	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CODMFHAM_01672	3.83e-104	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
CODMFHAM_01673	4.89e-91	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CODMFHAM_01674	2.67e-185	purR	-	-	F	ko:K09685	-	ko00000,ko03000	operon repressor
CODMFHAM_01675	2.28e-227	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	3'-5' exoribonuclease yhaM
CODMFHAM_01676	4.63e-236	rmuC	-	-	S	ko:K09760	-	ko00000	RmuC domain protein
CODMFHAM_01677	2.73e-153	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
CODMFHAM_01678	2.76e-153	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
CODMFHAM_01679	2.17e-208	rsgA	3.1.3.100	-	G	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
CODMFHAM_01681	3.7e-200	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
CODMFHAM_01682	1.27e-128	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CODMFHAM_01683	2.6e-184	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	Hydrolase, tatd
CODMFHAM_01684	8.04e-99	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
CODMFHAM_01685	3.77e-68	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
CODMFHAM_01686	1.23e-183	-	-	-	S	-	-	-	Macro domain protein
CODMFHAM_01687	4.04e-15	yneP	-	-	L	ko:K07107	-	ko00000,ko01000	thioesterase
CODMFHAM_01688	4.8e-72	bta	1.8.1.8	-	CO	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko03110	cell redox homeostasis
CODMFHAM_01691	3.46e-289	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
CODMFHAM_01692	9.4e-110	-	-	-	L	ko:K07491	-	ko00000	Transposase
CODMFHAM_01693	9.33e-20	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L34
CODMFHAM_01694	1.19e-237	jag	-	-	S	ko:K06346	-	ko00000	RNA-binding protein
CODMFHAM_01695	1.8e-180	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CODMFHAM_01696	7.08e-74	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
CODMFHAM_01697	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Argininosuccinate lyase
CODMFHAM_01698	7.52e-293	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
CODMFHAM_01699	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CODMFHAM_01700	8.5e-83	amiA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
CODMFHAM_01701	1.82e-97	amiA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
CODMFHAM_01702	1.66e-156	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
CODMFHAM_01703	1.69e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CODMFHAM_01704	3.28e-66	-	-	-	S	-	-	-	Protein of unknown function (DUF3397)
CODMFHAM_01705	9.62e-116	cah	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
CODMFHAM_01706	7.36e-75	-	-	-	S	-	-	-	Mitochondrial biogenesis AIM24
CODMFHAM_01707	3.23e-16	-	-	-	S	-	-	-	Mitochondrial biogenesis AIM24
CODMFHAM_01708	1.08e-287	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CODMFHAM_01709	2.98e-104	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
CODMFHAM_01710	3.06e-27	XK27_09620	-	-	S	-	-	-	FMN reductase (NADPH) activity
CODMFHAM_01711	3.17e-95	-	-	-	S	-	-	-	reductase
CODMFHAM_01712	5.96e-75	XK27_09615	-	-	C	ko:K19784	-	ko00000	reductase
CODMFHAM_01713	1.85e-179	XK27_09615	-	-	C	ko:K19784	-	ko00000	reductase
CODMFHAM_01714	3.16e-66	nirC_1	-	-	P	-	-	-	Formate nitrite transporter
CODMFHAM_01715	6.28e-65	nirC_1	-	-	P	-	-	-	Formate nitrite transporter
CODMFHAM_01716	1.91e-63	XK27_08585	-	-	S	ko:K16926	-	ko00000,ko00002,ko02000	Psort location CytoplasmicMembrane, score
CODMFHAM_01717	9.84e-237	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
CODMFHAM_01718	9.25e-217	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
CODMFHAM_01719	2.39e-154	gluP	3.4.21.105	-	O	ko:K19225	-	ko00000,ko01000,ko01002	membrane protein (homolog of Drosophila rhomboid)
CODMFHAM_01720	1.15e-121	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CODMFHAM_01721	2.31e-281	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
CODMFHAM_01722	6.92e-105	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
CODMFHAM_01723	2.68e-63	-	-	-	S	ko:K07025	-	ko00000	glycolate biosynthetic process
CODMFHAM_01724	9.2e-87	-	-	-	S	ko:K07025	-	ko00000	phosphatase activity
CODMFHAM_01725	1.16e-201	rrmA	2.1.1.187	-	Q	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	methyltransferase
CODMFHAM_01728	3.44e-117	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
CODMFHAM_01729	3.13e-86	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
CODMFHAM_01730	9.18e-49	yeeD	-	-	O	ko:K07112	-	ko00000	sulfur carrier activity
CODMFHAM_01731	1.65e-241	yeeE	-	-	S	ko:K07112	-	ko00000	Sulphur transport
CODMFHAM_01732	5.51e-147	XK27_10290	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
CODMFHAM_01733	4.07e-72	ytpP	-	-	CO	-	-	-	Thioredoxin
CODMFHAM_01735	6.4e-261	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
CODMFHAM_01736	1.17e-170	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CODMFHAM_01737	3.37e-143	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family protein
CODMFHAM_01739	3.21e-86	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
CODMFHAM_01740	9.06e-45	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
CODMFHAM_01741	4.3e-36	lanR	-	-	K	ko:K07729	-	ko00000,ko03000	sequence-specific DNA binding
CODMFHAM_01742	8.04e-283	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CODMFHAM_01743	2.04e-227	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
CODMFHAM_01744	5.13e-17	-	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Putative Competence protein ComGF
CODMFHAM_01745	5.36e-92	comGF	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Competence protein ComGF
CODMFHAM_01746	1.28e-21	-	-	-	NU	-	-	-	Type II secretory pathway pseudopilin
CODMFHAM_01747	1.03e-75	cglD	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	Competence protein
CODMFHAM_01748	9.09e-62	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
CODMFHAM_01749	3.14e-115	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
CODMFHAM_01750	9.49e-56	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
CODMFHAM_01751	1.27e-223	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CODMFHAM_01752	1.32e-89	-	-	-	S	-	-	-	cog cog4699
CODMFHAM_01753	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CODMFHAM_01754	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CODMFHAM_01755	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
CODMFHAM_01756	1.65e-304	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CODMFHAM_01757	2.67e-250	ilvC	1.1.1.86	-	H	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CODMFHAM_01758	1.37e-98	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
CODMFHAM_01759	0.0	ilvB	2.2.1.6	-	EH	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
CODMFHAM_01760	1.21e-313	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
CODMFHAM_01761	1.06e-80	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
CODMFHAM_01762	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
CODMFHAM_01763	1.09e-75	asp	-	-	S	-	-	-	cog cog1302
CODMFHAM_01764	9.21e-287	norN	-	-	V	-	-	-	Mate efflux family protein
CODMFHAM_01765	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
CODMFHAM_01766	6.68e-77	adh	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
CODMFHAM_01767	1.81e-43	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	hydroxyacid-oxoacid transhydrogenase activity
CODMFHAM_01768	1.21e-87	adh	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
CODMFHAM_01769	2.33e-162	adh	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
CODMFHAM_01770	1.37e-69	-	1.1.1.1, 1.2.1.10, 1.2.1.87	-	C	ko:K04072,ko:K13922	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Dehydrogenase
CODMFHAM_01771	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
CODMFHAM_01772	4.39e-90	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
CODMFHAM_01773	6.73e-79	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
CODMFHAM_01774	4.25e-73	treB	2.7.1.201	-	G	ko:K02817,ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS System
CODMFHAM_01775	2.66e-29	treR	-	-	K	ko:K03486,ko:K03710	-	ko00000,ko03000	DNA-binding transcription factor activity
CODMFHAM_01776	9.24e-114	treR	-	-	K	ko:K03486	-	ko00000,ko03000	trehalose operon
CODMFHAM_01777	1.17e-122	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
CODMFHAM_01780	2.9e-41	-	-	-	L	ko:K07482	-	ko00000	PFAM Integrase, catalytic core
CODMFHAM_01781	9.95e-211	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	aldolase
CODMFHAM_01783	2.25e-75	-	6.3.2.2	-	H	ko:K01919,ko:K06048	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	ergothioneine biosynthetic process
CODMFHAM_01784	2.93e-23	-	-	-	H	-	-	-	gamma-glutamylcysteine synthetase
CODMFHAM_01785	6.93e-15	-	-	-	H	-	-	-	gamma-glutamylcysteine synthetase
CODMFHAM_01786	7.03e-111	-	-	-	L	ko:K07482	-	ko00000	PFAM Integrase, catalytic core
CODMFHAM_01787	3.54e-82	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein l17
CODMFHAM_01788	5.37e-220	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CODMFHAM_01789	1.57e-80	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CODMFHAM_01790	4.42e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CODMFHAM_01791	3.26e-22	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
CODMFHAM_01792	6.91e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CODMFHAM_01793	2.61e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
CODMFHAM_01794	3.68e-294	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
CODMFHAM_01795	3.45e-85	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
CODMFHAM_01796	1.65e-31	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein l30
CODMFHAM_01797	9.94e-104	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CODMFHAM_01798	5.03e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CODMFHAM_01799	1.44e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CODMFHAM_01800	3.78e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CODMFHAM_01801	2.03e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CODMFHAM_01802	5.86e-122	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CODMFHAM_01803	1.63e-63	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CODMFHAM_01804	1.04e-78	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CODMFHAM_01805	3.08e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CODMFHAM_01806	4.36e-35	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
CODMFHAM_01807	3.58e-93	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CODMFHAM_01808	1.1e-151	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CODMFHAM_01809	1.21e-71	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CODMFHAM_01810	1.99e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CODMFHAM_01811	7.19e-196	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CODMFHAM_01812	6e-60	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
CODMFHAM_01813	2.9e-133	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
CODMFHAM_01814	2.23e-142	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CODMFHAM_01815	4.29e-64	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
CODMFHAM_01816	2.95e-239	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
CODMFHAM_01817	0.0	XK27_09800	-	-	I	-	-	-	Acyltransferase
CODMFHAM_01818	4.89e-47	-	-	-	S	-	-	-	MORN repeat protein
CODMFHAM_01819	3.25e-106	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CODMFHAM_01820	8.79e-131	-	-	-	L	ko:K07485	-	ko00000	Transposase
CODMFHAM_01821	1.13e-89	-	-	-	L	-	-	-	Transposase
CODMFHAM_01823	3.05e-212	cps1C	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
CODMFHAM_01824	1.93e-316	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CODMFHAM_01825	3.74e-113	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
CODMFHAM_01826	2.24e-110	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
CODMFHAM_01827	6.59e-67	flaR	-	-	F	-	-	-	topology modulation protein
CODMFHAM_01828	4.55e-30	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
CODMFHAM_01829	3.95e-145	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
CODMFHAM_01830	2.42e-39	-	-	-	S	-	-	-	Domain of unknown function (DUF4649)
CODMFHAM_01832	4.36e-302	rarA	-	-	L	ko:K07478	-	ko00000	ATPase related to the helicase subunit of the Holliday junction resolvase
CODMFHAM_01833	1.73e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
CODMFHAM_01834	4.83e-59	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
CODMFHAM_01835	2.06e-93	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CODMFHAM_01836	6.38e-61	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
CODMFHAM_01837	0.0	-	-	-	S	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
CODMFHAM_01838	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
CODMFHAM_01839	7.68e-20	-	-	-	-	-	-	-	-
CODMFHAM_01840	1.87e-118	-	-	-	K	-	-	-	acetyltransferase
CODMFHAM_01841	2.18e-150	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CODMFHAM_01842	1.56e-185	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
CODMFHAM_01843	4.89e-212	XK27_01785	-	-	S	-	-	-	cog cog1284
CODMFHAM_01844	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
CODMFHAM_01846	3.92e-307	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
CODMFHAM_01847	4.56e-169	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
CODMFHAM_01848	2e-36	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
CODMFHAM_01849	4.33e-36	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
CODMFHAM_01850	1.22e-26	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
CODMFHAM_01852	5.2e-62	yegS	-	-	I	-	-	-	Diacylglycerol kinase
CODMFHAM_01853	8.43e-124	-	-	-	S	-	-	-	Hydrophobic domain protein
CODMFHAM_01855	8.93e-130	-	-	-	-	-	-	-	-
CODMFHAM_01856	7.53e-33	-	-	-	S	-	-	-	Small integral membrane protein
CODMFHAM_01857	8.52e-107	-	-	-	M	-	-	-	Protein conserved in bacteria
CODMFHAM_01858	1.66e-34	-	-	-	K	-	-	-	CsbD-like
CODMFHAM_01859	1.18e-127	XK27_06885	-	-	L	-	-	-	hydrolase
CODMFHAM_01860	2.69e-11	XK27_06885	-	-	L	-	-	-	hydrolase
CODMFHAM_01861	1.3e-26	-	-	-	K	ko:K10947	-	ko00000,ko03000	negative regulation of transcription, DNA-templated
CODMFHAM_01862	4.32e-33	-	-	-	K	ko:K10947	-	ko00000,ko03000	negative regulation of transcription, DNA-templated
CODMFHAM_01863	1.91e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
CODMFHAM_01864	7.15e-27	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
CODMFHAM_01865	6.72e-146	-	-	-	S	-	-	-	Putative adhesin
CODMFHAM_01866	3.56e-265	XK27_06930	-	-	V	ko:K01421	-	ko00000	domain protein
CODMFHAM_01867	3.98e-124	XK27_06935	-	-	K	-	-	-	transcriptional regulator
CODMFHAM_01868	2.2e-68	ypaA	-	-	S	ko:K08987	-	ko00000	membrane
CODMFHAM_01869	1.21e-12	-	-	-	-	-	-	-	-
CODMFHAM_01870	6.91e-140	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CODMFHAM_01871	3.05e-63	WQ51_01655	-	-	S	-	-	-	Biofilm formation stimulator VEG
CODMFHAM_01872	1.29e-312	dnaC	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
CODMFHAM_01873	1.02e-97	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
CODMFHAM_01874	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
CODMFHAM_01875	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
CODMFHAM_01876	1.46e-101	-	-	-	F	-	-	-	NUDIX domain
CODMFHAM_01877	6.6e-279	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
CODMFHAM_01878	0.0	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
CODMFHAM_01879	3.54e-119	isaA	-	-	M	-	-	-	Immunodominant staphylococcal antigen A
CODMFHAM_01880	1.37e-122	lytE	-	-	M	-	-	-	LysM domain protein
CODMFHAM_01881	1.73e-176	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CODMFHAM_01882	2.6e-195	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CODMFHAM_01883	6.38e-194	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CODMFHAM_01884	5.4e-118	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CODMFHAM_01885	6.23e-185	ymfM	-	-	S	ko:K15539	-	ko00000	sequence-specific DNA binding
CODMFHAM_01886	8.54e-306	ymfH	-	-	S	-	-	-	Peptidase M16
CODMFHAM_01887	1.4e-157	albE	-	-	S	-	-	-	Peptidase M16
CODMFHAM_01888	6.72e-128	albE	-	-	S	-	-	-	Peptidase M16
CODMFHAM_01889	3.7e-69	yaaA	-	-	S	-	-	-	S4 domain protein YaaA
CODMFHAM_01890	2.24e-262	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CODMFHAM_01891	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
CODMFHAM_01892	1.17e-244	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
CODMFHAM_01893	3.96e-195	XK27_10395	-	-	S	-	-	-	membrane
CODMFHAM_01894	0.0	ykpA	-	-	S	-	-	-	abc transporter atp-binding protein
CODMFHAM_01895	0.0	XK27_10405	-	-	S	-	-	-	Bacterial membrane protein YfhO
CODMFHAM_01899	3.66e-155	yveI	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
CODMFHAM_01900	7.01e-109	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CODMFHAM_01901	7.25e-268	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
CODMFHAM_01902	9.27e-172	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
CODMFHAM_01903	3.22e-156	-	-	-	L	-	-	-	Transposase
CODMFHAM_01905	4.67e-162	-	-	-	L	ko:K07498	-	ko00000	Transposase
CODMFHAM_01906	6.34e-13	-	-	-	L	-	-	-	Transposase
CODMFHAM_01907	9.2e-221	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	Psort location CytoplasmicMembrane, score 10.00
CODMFHAM_01908	1.52e-268	-	4.1.1.15	-	E	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	ko00000,ko00001,ko00002,ko01000	Belongs to the group II decarboxylase family