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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
BIGEKKFO_00001	8.95e-315	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIGEKKFO_00002	8.19e-267	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
BIGEKKFO_00003	3.82e-51	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
BIGEKKFO_00004	7.24e-263	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIGEKKFO_00005	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIGEKKFO_00006	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIGEKKFO_00007	5.95e-65	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
BIGEKKFO_00008	1.68e-108	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
BIGEKKFO_00009	2.69e-47	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIGEKKFO_00010	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIGEKKFO_00011	3.44e-95	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
BIGEKKFO_00012	3.15e-315	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
BIGEKKFO_00013	3.35e-287	yttB	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_00014	9e-184	proB	2.7.2.11	-	F	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIGEKKFO_00015	2.67e-291	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIGEKKFO_00017	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_00018	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIGEKKFO_00019	6.65e-282	glgC	2.7.7.27	-	H	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIGEKKFO_00020	7.03e-269	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
BIGEKKFO_00021	0.0	glgA	2.4.1.21	GT5	F	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000,ko01003	Synthesizes alpha-1,4-glucan chains using ADP-glucose
BIGEKKFO_00022	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
BIGEKKFO_00023	0.0	malZ	3.2.1.20, 3.2.1.41	CBM48,GH13,GH31	G	ko:K01187,ko:K01200	ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
BIGEKKFO_00025	8.38e-184	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
BIGEKKFO_00026	1.1e-154	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	beta-phosphoglucomutase
BIGEKKFO_00027	0.0	trePP	2.4.1.216, 2.4.1.8	GH65	G	ko:K00691,ko:K03731	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65 central catalytic domain
BIGEKKFO_00028	3.21e-104	-	-	-	S	-	-	-	Pyridoxamine 5'-phosphate oxidase
BIGEKKFO_00029	4.37e-43	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein domain
BIGEKKFO_00030	2.54e-50	-	-	-	-	-	-	-	-
BIGEKKFO_00032	1.56e-169	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
BIGEKKFO_00033	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGEKKFO_00034	2.05e-312	yycH	-	-	S	-	-	-	YycH protein
BIGEKKFO_00035	3.54e-195	yycI	-	-	S	-	-	-	YycH protein
BIGEKKFO_00036	1.71e-200	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
BIGEKKFO_00037	1.5e-253	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
BIGEKKFO_00038	3.52e-106	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIGEKKFO_00039	8.71e-45	-	-	-	L	-	-	-	AAA ATPase domain
BIGEKKFO_00040	6.62e-119	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
BIGEKKFO_00041	2.33e-157	pnb	-	-	C	-	-	-	nitroreductase
BIGEKKFO_00042	4.95e-86	-	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	6-pyruvoyl tetrahydropterin synthase
BIGEKKFO_00043	1.57e-150	-	-	-	S	-	-	-	Elongation factor G-binding protein, N-terminal
BIGEKKFO_00044	0.0	-	-	-	C	-	-	-	FMN_bind
BIGEKKFO_00045	0.0	-	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
BIGEKKFO_00046	1.46e-204	-	-	-	K	-	-	-	LysR family
BIGEKKFO_00047	2.49e-95	-	-	-	C	-	-	-	FMN binding
BIGEKKFO_00048	4.48e-98	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIGEKKFO_00049	4.06e-211	-	-	-	S	-	-	-	KR domain
BIGEKKFO_00050	5.74e-204	adc	4.1.1.4	-	Q	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	ko00000,ko00001,ko00002,ko01000	Acetoacetate decarboxylase (ADC)
BIGEKKFO_00051	5.07e-157	ydgI	-	-	C	-	-	-	Nitroreductase family
BIGEKKFO_00052	0.0	-	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
BIGEKKFO_00053	1.56e-154	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	beta-phosphoglucomutase
BIGEKKFO_00054	2.66e-249	pva1	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
BIGEKKFO_00055	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
BIGEKKFO_00056	1.14e-173	ptp1	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
BIGEKKFO_00057	0.0	hpaH	1.14.14.8, 1.14.14.9	-	Q	ko:K00483,ko:K16901	ko00350,ko00380,ko01120,ko01220,map00350,map00380,map01120,map01220	ko00000,ko00001,ko01000	4-hydroxyphenylacetate
BIGEKKFO_00058	1.65e-106	-	-	-	S	-	-	-	ASCH
BIGEKKFO_00059	3.06e-165	-	-	-	F	-	-	-	glutamine amidotransferase
BIGEKKFO_00060	1.67e-220	-	-	-	K	-	-	-	WYL domain
BIGEKKFO_00061	6.65e-152	azoR	-	-	C	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIGEKKFO_00062	0.0	fusA1	-	-	J	-	-	-	elongation factor G
BIGEKKFO_00063	8.71e-83	-	-	-	S	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
BIGEKKFO_00065	2.2e-194	-	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_00066	1.72e-33	yfbM	-	-	K	-	-	-	FR47-like protein
BIGEKKFO_00067	1.4e-162	-	-	-	S	-	-	-	DJ-1/PfpI family
BIGEKKFO_00068	3.82e-231	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	nadph quinone reductase
BIGEKKFO_00069	1.92e-67	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_00070	5.98e-302	mepA	-	-	V	ko:K18908	-	ko00000,ko00002,ko01504,ko02000	MATE efflux family protein
BIGEKKFO_00071	9.01e-215	pepI	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
BIGEKKFO_00072	7.76e-181	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
BIGEKKFO_00073	2.38e-99	-	-	-	-	-	-	-	-
BIGEKKFO_00074	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
BIGEKKFO_00075	5.9e-181	-	-	-	-	-	-	-	-
BIGEKKFO_00076	4.07e-05	-	-	-	-	-	-	-	-
BIGEKKFO_00077	2.92e-186	ant1	2.7.7.47	-	H	ko:K00984	-	ko00000,ko01000,ko01504	Mediates bacterial resistance to the antibiotics streptomycin and spectomycin
BIGEKKFO_00078	1.67e-54	-	-	-	-	-	-	-	-
BIGEKKFO_00079	4.29e-166	-	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_00080	5.82e-184	-	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
BIGEKKFO_00081	1.84e-235	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PDGLE domain
BIGEKKFO_00082	1.39e-156	rcfB	-	-	K	-	-	-	Crp-like helix-turn-helix domain
BIGEKKFO_00083	7.9e-306	larA	5.1.2.1	-	S	ko:K22373	ko00620,map00620	ko00000,ko00001,ko01000	Domain of unknown function (DUF2088)
BIGEKKFO_00084	2.65e-162	larB	-	-	S	ko:K06898	-	ko00000	AIR carboxylase
BIGEKKFO_00085	2.9e-178	larC	4.99.1.12	-	S	ko:K09121	-	ko00000,ko01000	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIGEKKFO_00086	1.75e-98	larC2	4.99.1.12	-	S	ko:K09121	-	ko00000,ko01000	Protein of unknown function DUF111
BIGEKKFO_00087	1.19e-170	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_00088	3.03e-192	larE	-	-	S	ko:K06864	-	ko00000	NAD synthase
BIGEKKFO_00089	2.07e-38	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
BIGEKKFO_00090	4.19e-169	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
BIGEKKFO_00091	1.08e-174	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIGEKKFO_00092	8.33e-189	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
BIGEKKFO_00093	2.68e-143	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
BIGEKKFO_00094	2.4e-260	thiP	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
BIGEKKFO_00095	1.02e-175	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
BIGEKKFO_00096	0.0	-	-	-	L	-	-	-	HIRAN domain
BIGEKKFO_00097	3.55e-109	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
BIGEKKFO_00098	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
BIGEKKFO_00099	1e-156	-	-	-	-	-	-	-	-
BIGEKKFO_00100	2.94e-191	-	-	-	I	-	-	-	Alpha/beta hydrolase family
BIGEKKFO_00101	0.0	pacL1	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
BIGEKKFO_00102	8.08e-185	-	-	-	F	-	-	-	Phosphorylase superfamily
BIGEKKFO_00103	2.92e-38	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain
BIGEKKFO_00104	5.13e-144	azo1	1.5.1.36, 1.7.1.6	-	S	ko:K03206,ko:K19784,ko:K22393	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
BIGEKKFO_00105	1.05e-97	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00106	3.28e-95	hsp1	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
BIGEKKFO_00107	1.8e-288	-	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
BIGEKKFO_00108	2.21e-65	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_00109	2.79e-274	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	Transporter, major facilitator family protein
BIGEKKFO_00111	3.07e-204	morA	-	-	S	-	-	-	reductase
BIGEKKFO_00112	8.21e-213	-	1.1.1.65	-	C	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	ko00000,ko00001,ko01000	Aldo keto reductase
BIGEKKFO_00113	3.19e-105	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase like
BIGEKKFO_00114	0.0	l1n	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
BIGEKKFO_00115	2.65e-116	-	-	-	-	-	-	-	-
BIGEKKFO_00116	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_00117	6.49e-268	-	-	-	C	-	-	-	Oxidoreductase
BIGEKKFO_00118	2.21e-191	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
BIGEKKFO_00119	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_00120	2.57e-128	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
BIGEKKFO_00121	4.37e-167	-	-	-	K	ko:K03492	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
BIGEKKFO_00122	4.14e-72	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGEKKFO_00123	3.14e-182	-	-	-	-	-	-	-	-
BIGEKKFO_00124	1.35e-46	-	-	-	-	-	-	-	-
BIGEKKFO_00125	3.59e-119	-	-	-	-	-	-	-	-
BIGEKKFO_00126	3.37e-115	-	-	-	-	-	-	-	-
BIGEKKFO_00127	7.14e-185	dhrS4	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Oxidoreductase, short chain dehydrogenase reductase family protein
BIGEKKFO_00128	7.04e-217	ybhF_1	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_00129	0.0	-	-	-	M	ko:K01992	-	ko00000,ko00002,ko02000	Exporter of polyketide antibiotics
BIGEKKFO_00130	9.77e-152	-	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_00131	0.0	etfA	1.3.1.108	-	C	ko:K03522,ko:K22432	-	ko00000,ko01000,ko04147	Electron transfer flavoprotein FAD-binding domain
BIGEKKFO_00132	2.04e-99	-	-	-	T	-	-	-	ECF transporter, substrate-specific component
BIGEKKFO_00134	1.85e-121	XK27_02085	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00135	2.35e-243	dhaK2	2.7.1.28, 2.7.1.29, 4.6.1.15	-	G	ko:K00863	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	ko00000,ko00001,ko00002,ko01000	Dak1 domain
BIGEKKFO_00136	3.88e-239	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
BIGEKKFO_00137	2.75e-131	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
BIGEKKFO_00138	2.76e-74	dhaM	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
BIGEKKFO_00139	4e-172	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_00140	2.65e-245	malR1	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
BIGEKKFO_00141	2.13e-230	yvdE	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
BIGEKKFO_00142	0.0	malA1	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
BIGEKKFO_00143	9.45e-299	mdxE	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGEKKFO_00144	3.74e-302	malC	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_00145	2.83e-206	malD	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00146	1.75e-191	malA	-	-	S	-	-	-	maltodextrose utilization protein MalA
BIGEKKFO_00147	0.0	malS	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Glycogen debranching enzyme, glucanotransferase domain
BIGEKKFO_00148	2.44e-267	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGEKKFO_00149	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
BIGEKKFO_00150	2.4e-170	-	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 85
BIGEKKFO_00151	0.0	-	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 85
BIGEKKFO_00152	8.23e-61	ygbF	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
BIGEKKFO_00153	1.54e-216	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
BIGEKKFO_00154	0.0	melA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
BIGEKKFO_00155	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_00156	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
BIGEKKFO_00157	1.39e-229	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	Transcriptional regulator, LacI family
BIGEKKFO_00158	0.0	-	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
BIGEKKFO_00159	3.32e-210	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	nadph quinone reductase
BIGEKKFO_00160	0.0	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
BIGEKKFO_00161	0.0	malL	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
BIGEKKFO_00162	5.99e-213	mleR	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_00163	0.0	-	-	-	M	-	-	-	domain protein
BIGEKKFO_00165	1.03e-201	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix
BIGEKKFO_00166	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_00167	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_00168	9.25e-103	yiaC	-	-	K	ko:K03826	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
BIGEKKFO_00169	8.37e-278	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGEKKFO_00170	1.24e-259	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIGEKKFO_00171	2.73e-147	pgm1	-	-	G	-	-	-	phosphoglycerate mutase
BIGEKKFO_00172	1.75e-229	yghZ	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo keto reductase family protein
BIGEKKFO_00173	6.33e-46	-	-	-	-	-	-	-	-
BIGEKKFO_00174	4.69e-79	-	-	-	S	-	-	-	Domain of unknown function (DU1801)
BIGEKKFO_00175	4.37e-208	fbpA	-	-	K	-	-	-	Domain of unknown function (DUF814)
BIGEKKFO_00176	1.29e-278	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIGEKKFO_00177	3.81e-18	-	-	-	-	-	-	-	-
BIGEKKFO_00178	3.18e-77	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIGEKKFO_00179	5.66e-74	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIGEKKFO_00180	0.0	-	-	-	S	ko:K18231,ko:K19349	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_00181	8.68e-150	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
BIGEKKFO_00182	0.0	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGEKKFO_00183	1.43e-131	-	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00184	6.07e-117	gpo	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
BIGEKKFO_00185	5.09e-200	dkgB	-	-	S	-	-	-	reductase
BIGEKKFO_00186	1.28e-102	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
BIGEKKFO_00187	2.36e-49	-	-	-	-	-	-	-	-
BIGEKKFO_00188	1.61e-18	-	-	-	-	-	-	-	-
BIGEKKFO_00189	3.16e-170	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
BIGEKKFO_00191	0.0	pepD1	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
BIGEKKFO_00192	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_00193	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	Mga helix-turn-helix domain
BIGEKKFO_00194	5.33e-103	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00195	4.33e-281	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
BIGEKKFO_00196	2.43e-111	-	-	-	-	-	-	-	-
BIGEKKFO_00197	1.96e-75	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
BIGEKKFO_00198	7.19e-68	-	-	-	-	-	-	-	-
BIGEKKFO_00199	1.22e-125	-	-	-	-	-	-	-	-
BIGEKKFO_00200	2.98e-90	-	-	-	-	-	-	-	-
BIGEKKFO_00201	2.41e-106	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Belongs to the NDK family
BIGEKKFO_00202	0.0	-	-	-	S	ko:K13730	ko05100,map05100	ko00000,ko00001	Uncharacterized protein conserved in bacteria (DUF2252)
BIGEKKFO_00203	2.21e-127	-	-	-	S	ko:K19784	-	ko00000	NADPH-dependent FMN reductase
BIGEKKFO_00204	1.89e-159	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
BIGEKKFO_00205	1.66e-290	pts3C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00206	6.14e-53	-	-	-	-	-	-	-	-
BIGEKKFO_00207	9.23e-270	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
BIGEKKFO_00208	5.16e-271	dho	3.5.2.3	-	S	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase family
BIGEKKFO_00209	2.92e-258	selA	2.9.1.1	-	H	ko:K01042	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko01000	L-seryl-tRNA selenium transferase
BIGEKKFO_00210	1.22e-166	-	4.1.2.14	-	S	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	ko00000,ko00001,ko00002,ko01000	KDGP aldolase
BIGEKKFO_00211	5.78e-245	-	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	pfkB family carbohydrate kinase
BIGEKKFO_00212	3.53e-123	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Bacterial transferase hexapeptide (six repeats)
BIGEKKFO_00213	5.78e-268	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
BIGEKKFO_00214	1.3e-211	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
BIGEKKFO_00215	6.72e-203	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
BIGEKKFO_00216	1.27e-181	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
BIGEKKFO_00217	7.55e-58	-	-	-	S	-	-	-	Protein of unknown function (DUF2089)
BIGEKKFO_00218	2.21e-56	-	-	-	-	-	-	-	-
BIGEKKFO_00219	1.68e-166	treR	-	-	K	ko:K03486	-	ko00000,ko03000	UTRA
BIGEKKFO_00220	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
BIGEKKFO_00221	0.0	pts4ABC	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_00222	0.0	pts5ABC	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
BIGEKKFO_00223	2.6e-185	-	-	-	-	-	-	-	-
BIGEKKFO_00224	6.2e-129	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
BIGEKKFO_00225	3.2e-91	-	-	-	-	-	-	-	-
BIGEKKFO_00226	5.15e-95	ywnA	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00227	1.05e-155	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00228	4.02e-301	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
BIGEKKFO_00229	1.15e-152	-	-	-	-	-	-	-	-
BIGEKKFO_00230	2.92e-57	-	-	-	-	-	-	-	-
BIGEKKFO_00231	1.55e-55	-	-	-	-	-	-	-	-
BIGEKKFO_00232	0.0	ydiC	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_00233	2.2e-86	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_00234	4.9e-315	hpk2	-	-	T	-	-	-	Histidine kinase
BIGEKKFO_00235	3.28e-166	rrp2	-	-	K	-	-	-	Transcriptional regulatory protein, C terminal
BIGEKKFO_00236	2.42e-65	-	-	-	-	-	-	-	-
BIGEKKFO_00237	1.96e-167	yidA	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGEKKFO_00238	6.86e-311	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00239	3.35e-75	-	-	-	-	-	-	-	-
BIGEKKFO_00240	2.87e-56	-	-	-	-	-	-	-	-
BIGEKKFO_00241	7.18e-236	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
BIGEKKFO_00242	0.0	loxD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
BIGEKKFO_00243	1.49e-63	-	-	-	-	-	-	-	-
BIGEKKFO_00244	2.04e-158	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
BIGEKKFO_00245	1.17e-135	-	-	-	K	-	-	-	transcriptional regulator
BIGEKKFO_00246	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	MMPL family
BIGEKKFO_00247	3.8e-135	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
BIGEKKFO_00248	0.0	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
BIGEKKFO_00249	1.76e-293	vex3	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
BIGEKKFO_00250	4.87e-156	vex2	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_00251	1.5e-253	tnpA1	-	-	L	-	-	-	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
BIGEKKFO_00252	5.5e-05	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00253	7.98e-80	-	-	-	M	-	-	-	Lysin motif
BIGEKKFO_00254	2.31e-95	-	-	-	M	-	-	-	LysM domain protein
BIGEKKFO_00255	4.2e-88	gcsH1	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Glycine cleavage H-protein
BIGEKKFO_00256	6.1e-227	-	-	-	-	-	-	-	-
BIGEKKFO_00257	2.8e-169	-	-	-	-	-	-	-	-
BIGEKKFO_00258	0.0	uvrB3	3.1.12.1	-	KL	ko:K07464	-	ko00000,ko01000,ko02048	DEAD_2
BIGEKKFO_00259	2.03e-75	-	-	-	-	-	-	-	-
BIGEKKFO_00260	1.3e-284	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIGEKKFO_00261	7.61e-102	-	-	-	S	ko:K02348	-	ko00000	GNAT family
BIGEKKFO_00262	1.24e-99	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00263	3.91e-287	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
BIGEKKFO_00264	6.01e-51	-	-	-	-	-	-	-	-
BIGEKKFO_00266	1.04e-35	-	-	-	-	-	-	-	-
BIGEKKFO_00267	9.25e-32	-	-	-	U	-	-	-	Preprotein translocase subunit SecB
BIGEKKFO_00268	5.3e-265	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_00269	1.31e-179	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00270	3.14e-190	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00271	5.94e-262	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
BIGEKKFO_00272	3.68e-125	-	-	-	K	-	-	-	Cupin domain
BIGEKKFO_00273	8.08e-110	-	-	-	S	-	-	-	ASCH
BIGEKKFO_00274	1.88e-111	-	-	-	K	-	-	-	GNAT family
BIGEKKFO_00275	2.14e-117	-	-	-	K	-	-	-	acetyltransferase
BIGEKKFO_00276	2.06e-30	-	-	-	-	-	-	-	-
BIGEKKFO_00277	5.05e-79	-	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
BIGEKKFO_00278	1.85e-208	-	-	-	V	ko:K01990,ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_00279	1.08e-243	-	-	-	-	-	-	-	-
BIGEKKFO_00280	0.0	acdH	1.1.1.1, 1.2.1.10, 1.2.1.87	-	C	ko:K04072,ko:K13922	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Aldehyde dehydrogenase family
BIGEKKFO_00281	1.16e-206	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
BIGEKKFO_00283	2.36e-305	xylP1	-	-	G	-	-	-	MFS/sugar transport protein
BIGEKKFO_00284	1.43e-170	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	prohibitin homologues
BIGEKKFO_00285	7.28e-42	-	-	-	-	-	-	-	-
BIGEKKFO_00286	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
BIGEKKFO_00287	6.4e-54	-	-	-	-	-	-	-	-
BIGEKKFO_00288	1.54e-123	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
BIGEKKFO_00289	1.49e-227	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
BIGEKKFO_00290	1.45e-79	-	-	-	S	-	-	-	CHY zinc finger
BIGEKKFO_00291	1.06e-143	metQ	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	NLPA lipoprotein
BIGEKKFO_00292	7.98e-158	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGEKKFO_00293	5.18e-115	metP_2	-	-	U	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_00294	5.67e-187	ykpB	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIGEKKFO_00295	2.94e-282	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
BIGEKKFO_00296	5.25e-279	-	-	-	-	-	-	-	-
BIGEKKFO_00297	8.13e-199	tagG	-	-	U	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
BIGEKKFO_00298	9.42e-258	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
BIGEKKFO_00299	3.93e-59	-	-	-	-	-	-	-	-
BIGEKKFO_00300	2.39e-121	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGEKKFO_00301	0.0	-	-	-	P	-	-	-	Major Facilitator Superfamily
BIGEKKFO_00302	1.05e-308	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
BIGEKKFO_00303	1.49e-225	hicD1	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
BIGEKKFO_00304	8.95e-60	-	-	-	-	-	-	-	-
BIGEKKFO_00305	2.03e-130	zmp1	-	-	O	-	-	-	Zinc-dependent metalloprotease
BIGEKKFO_00306	1.14e-151	rpiA2	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
BIGEKKFO_00307	0.0	sufI	-	-	Q	-	-	-	Multicopper oxidase
BIGEKKFO_00308	1.08e-71	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
BIGEKKFO_00309	1.31e-124	yxkA	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
BIGEKKFO_00310	1.61e-294	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
BIGEKKFO_00311	8.37e-108	-	-	-	K	-	-	-	Winged helix-turn-helix transcription repressor, HrcA DNA-binding
BIGEKKFO_00312	2.16e-103	-	-	-	-	-	-	-	-
BIGEKKFO_00313	2.43e-103	accB3	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
BIGEKKFO_00314	3.66e-224	rihA	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
BIGEKKFO_00315	1.07e-208	yneD	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_00316	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_00317	7.02e-103	-	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA-DNA hybrid ribonuclease activity
BIGEKKFO_00318	0.0	proWX	-	-	EM	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
BIGEKKFO_00319	1.1e-229	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_00320	0.0	gshR	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Pyridine nucleotide-disulphide oxidoreductase
BIGEKKFO_00321	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIGEKKFO_00322	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
BIGEKKFO_00323	2.5e-173	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_00324	0.0	-	-	-	M	-	-	-	domain protein
BIGEKKFO_00325	1.05e-77	-	-	-	M	-	-	-	dTDP-4-dehydrorhamnose reductase activity
BIGEKKFO_00327	7.35e-50	-	-	-	-	-	-	-	-
BIGEKKFO_00328	1.65e-88	-	-	-	S	-	-	-	Immunity protein 63
BIGEKKFO_00329	1.51e-17	-	-	-	L	-	-	-	LXG domain of WXG superfamily
BIGEKKFO_00330	1.93e-59	-	-	-	-	-	-	-	-
BIGEKKFO_00331	8.5e-55	-	-	-	-	-	-	-	-
BIGEKKFO_00332	4.47e-229	-	-	-	-	-	-	-	-
BIGEKKFO_00333	1.24e-11	-	-	-	S	-	-	-	Immunity protein 22
BIGEKKFO_00334	5.89e-131	-	-	-	S	-	-	-	ankyrin repeats
BIGEKKFO_00335	1.71e-45	-	-	-	-	-	-	-	-
BIGEKKFO_00336	8.53e-28	-	-	-	-	-	-	-	-
BIGEKKFO_00337	5.52e-64	-	-	-	U	-	-	-	nuclease activity
BIGEKKFO_00338	2.05e-90	-	-	-	-	-	-	-	-
BIGEKKFO_00339	1.54e-28	-	-	-	-	-	-	-	-
BIGEKKFO_00341	1.15e-39	-	-	-	-	-	-	-	-
BIGEKKFO_00342	3.27e-81	-	-	-	-	-	-	-	-
BIGEKKFO_00344	6.48e-154	lacA	2.3.1.18, 2.3.1.79	-	S	ko:K00633,ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
BIGEKKFO_00345	3.18e-262	-	-	-	EGP	-	-	-	Transporter, major facilitator family protein
BIGEKKFO_00346	2.4e-187	-	3.1.3.102, 3.1.3.104, 3.1.3.23	-	G	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_00347	2.35e-212	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00348	1.39e-190	-	-	-	S	-	-	-	hydrolase
BIGEKKFO_00349	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
BIGEKKFO_00350	8.8e-265	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
BIGEKKFO_00354	2.86e-47	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
BIGEKKFO_00355	1.15e-22	-	-	-	-	-	-	-	-
BIGEKKFO_00356	6.24e-25	plnR	-	-	-	-	-	-	-
BIGEKKFO_00357	3.68e-140	-	-	-	-	-	-	-	-
BIGEKKFO_00358	3.29e-32	plnK	-	-	-	-	-	-	-
BIGEKKFO_00359	8.53e-34	plnJ	-	-	-	-	-	-	-
BIGEKKFO_00360	3.98e-19	-	-	-	-	-	-	-	-
BIGEKKFO_00361	2.71e-156	plnP	-	-	S	-	-	-	CAAX protease self-immunity
BIGEKKFO_00363	1.07e-140	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
BIGEKKFO_00364	1.18e-170	plnD	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
BIGEKKFO_00365	4.71e-166	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00366	1.93e-31	plnF	-	-	-	-	-	-	-
BIGEKKFO_00367	8.82e-32	-	-	-	-	-	-	-	-
BIGEKKFO_00368	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
BIGEKKFO_00369	4.28e-309	mesE	-	-	M	ko:K12293,ko:K20345	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	Transport protein ComB
BIGEKKFO_00370	5.4e-36	sagE	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00371	3.4e-99	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00372	1.33e-150	plnU	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00373	1.25e-141	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00374	3.9e-146	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00375	3.12e-48	-	-	-	S	ko:K07334	-	ko00000,ko02048	RelE-like toxin of type II toxin-antitoxin system HigB
BIGEKKFO_00376	4.23e-64	axe	-	-	K	ko:K21498	-	ko00000,ko02048	Helix-turn-helix XRE-family like proteins
BIGEKKFO_00377	0.0	-	-	-	L	-	-	-	DNA helicase
BIGEKKFO_00378	3.54e-182	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
BIGEKKFO_00379	8.19e-244	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
BIGEKKFO_00380	2.69e-166	-	-	-	K	-	-	-	UbiC transcription regulator-associated domain protein
BIGEKKFO_00381	0.0	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00382	9.68e-34	-	-	-	-	-	-	-	-
BIGEKKFO_00383	3.42e-97	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
BIGEKKFO_00384	0.0	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00385	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_00386	6.97e-209	-	-	-	GK	-	-	-	ROK family
BIGEKKFO_00387	1.14e-173	yecA	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGEKKFO_00388	1.7e-243	dus	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIGEKKFO_00389	4.28e-263	-	-	-	-	-	-	-	-
BIGEKKFO_00390	8.42e-193	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
BIGEKKFO_00391	2.35e-215	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
BIGEKKFO_00392	1.37e-290	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
BIGEKKFO_00393	1.89e-228	-	-	-	-	-	-	-	-
BIGEKKFO_00394	3.56e-170	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	SIR2 family
BIGEKKFO_00395	1.12e-205	yunF	-	-	F	-	-	-	Protein of unknown function DUF72
BIGEKKFO_00396	4.64e-92	-	-	-	F	-	-	-	DNA mismatch repair protein MutT
BIGEKKFO_00397	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIGEKKFO_00398	7.06e-271	-	-	-	EGP	ko:K02030	-	ko00000,ko00002,ko02000	Drug resistance transporter Bcr CflA subfamily
BIGEKKFO_00399	1.63e-187	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
BIGEKKFO_00400	9.27e-127	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIGEKKFO_00401	2.5e-203	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
BIGEKKFO_00402	6.87e-50	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
BIGEKKFO_00403	3.08e-207	ispE	2.7.1.148	-	F	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIGEKKFO_00404	1.9e-230	-	-	-	S	ko:K06889	-	ko00000	Prolyl oligopeptidase family
BIGEKKFO_00405	8.05e-166	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGEKKFO_00406	6.39e-169	znuB	-	-	U	ko:K02075,ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
BIGEKKFO_00407	3.71e-15	-	-	-	T	ko:K21493	-	ko00000,ko01000,ko02048	Pre-toxin TG
BIGEKKFO_00408	2.95e-57	-	-	-	S	-	-	-	ankyrin repeats
BIGEKKFO_00409	5.3e-49	-	-	-	-	-	-	-	-
BIGEKKFO_00410	1.96e-189	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
BIGEKKFO_00411	9.41e-298	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIGEKKFO_00412	1.15e-195	bla1	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
BIGEKKFO_00413	3.26e-228	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIGEKKFO_00414	1.82e-232	-	-	-	S	-	-	-	DUF218 domain
BIGEKKFO_00415	7.12e-178	-	-	-	-	-	-	-	-
BIGEKKFO_00416	1.19e-190	yxeH	-	-	S	-	-	-	hydrolase
BIGEKKFO_00417	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	HD domain protein
BIGEKKFO_00418	8.97e-200	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	biotin lipoate A B protein ligase
BIGEKKFO_00419	2.87e-101	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
BIGEKKFO_00420	2.96e-89	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
BIGEKKFO_00421	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
BIGEKKFO_00422	6.81e-311	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGEKKFO_00423	2.28e-290	sdaC	-	-	E	ko:K03837	-	ko00000,ko02000	amino acid
BIGEKKFO_00424	1.52e-158	sdhB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
BIGEKKFO_00425	2.81e-202	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
BIGEKKFO_00426	6.59e-170	-	-	-	S	-	-	-	YheO-like PAS domain
BIGEKKFO_00427	4.01e-36	-	-	-	-	-	-	-	-
BIGEKKFO_00428	2.08e-302	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIGEKKFO_00429	6.26e-306	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIGEKKFO_00430	1.91e-55	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
BIGEKKFO_00431	2.57e-274	-	-	-	J	-	-	-	translation release factor activity
BIGEKKFO_00432	3.14e-164	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	sortase family
BIGEKKFO_00433	5.35e-121	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
BIGEKKFO_00434	5.58e-195	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
BIGEKKFO_00435	1.84e-189	-	-	-	-	-	-	-	-
BIGEKKFO_00436	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
BIGEKKFO_00437	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
BIGEKKFO_00438	9.32e-81	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
BIGEKKFO_00439	1.43e-274	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIGEKKFO_00440	4.28e-84	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
BIGEKKFO_00441	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
BIGEKKFO_00442	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
BIGEKKFO_00443	9.1e-261	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
BIGEKKFO_00444	4.22e-243	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIGEKKFO_00445	1.38e-293	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIGEKKFO_00446	2.36e-166	argB	2.7.2.8	-	F	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIGEKKFO_00447	4.66e-278	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine
BIGEKKFO_00448	2.63e-241	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIGEKKFO_00449	1.3e-110	queT	-	-	S	-	-	-	QueT transporter
BIGEKKFO_00450	4.87e-148	-	-	-	S	-	-	-	(CBS) domain
BIGEKKFO_00451	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
BIGEKKFO_00452	1.13e-225	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
BIGEKKFO_00453	8.29e-129	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
BIGEKKFO_00454	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIGEKKFO_00455	0.0	yabM	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
BIGEKKFO_00456	7.72e-57	yabO	-	-	J	-	-	-	S4 domain protein
BIGEKKFO_00458	2.02e-83	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
BIGEKKFO_00459	1.07e-103	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding
BIGEKKFO_00460	7.47e-225	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
BIGEKKFO_00461	1.99e-80	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
BIGEKKFO_00462	4.3e-124	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIGEKKFO_00463	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIGEKKFO_00464	1.93e-209	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIGEKKFO_00465	5.33e-243	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIGEKKFO_00466	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
BIGEKKFO_00469	1.35e-55	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
BIGEKKFO_00472	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
BIGEKKFO_00473	1.23e-193	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
BIGEKKFO_00477	9.02e-66	-	-	-	S	-	-	-	Cupin 2, conserved barrel domain protein
BIGEKKFO_00478	2.78e-71	-	-	-	S	-	-	-	Cupin domain
BIGEKKFO_00479	1.26e-211	pphA	3.1.3.16	-	T	ko:K07313	-	ko00000,ko01000	Calcineurin-like phosphoesterase
BIGEKKFO_00480	1.59e-247	ysdE	-	-	P	-	-	-	Citrate transporter
BIGEKKFO_00481	1.06e-195	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
BIGEKKFO_00482	2.65e-175	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIGEKKFO_00483	2.92e-280	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIGEKKFO_00484	5.41e-160	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
BIGEKKFO_00485	3.99e-177	tagA	2.4.1.187	GT26	F	ko:K05946	ko05111,map05111	ko00000,ko00001,ko01000,ko01003	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
BIGEKKFO_00486	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIGEKKFO_00487	5.27e-197	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
BIGEKKFO_00488	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
BIGEKKFO_00489	2.57e-94	-	-	-	-	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	-
BIGEKKFO_00490	0.0	tex	-	-	K	ko:K06959	-	ko00000	Tex-like protein N-terminal domain protein
BIGEKKFO_00491	2.09e-104	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
BIGEKKFO_00492	1.71e-302	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
BIGEKKFO_00493	1.19e-201	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
BIGEKKFO_00495	1e-200	-	-	-	G	-	-	-	Peptidase_C39 like family
BIGEKKFO_00496	6.46e-218	manL	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
BIGEKKFO_00497	4.51e-172	manM	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system
BIGEKKFO_00498	1.87e-219	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
BIGEKKFO_00499	9.05e-85	manO	-	-	S	-	-	-	Domain of unknown function (DUF956)
BIGEKKFO_00500	0.0	levR	-	-	K	-	-	-	Sigma-54 interaction domain
BIGEKKFO_00501	7.19e-94	levD	2.7.1.191, 2.7.1.202	-	G	ko:K02793,ko:K02794,ko:K11194	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
BIGEKKFO_00502	4.5e-113	manX	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
BIGEKKFO_00503	3.15e-229	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIGEKKFO_00504	9.24e-85	accB1	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin-requiring enzyme
BIGEKKFO_00505	4.82e-315	accC1	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase C-terminal domain
BIGEKKFO_00506	6.33e-185	accD1	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIGEKKFO_00507	1.23e-177	accA1	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
BIGEKKFO_00508	2.29e-234	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
BIGEKKFO_00509	7.53e-215	mleP2	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
BIGEKKFO_00510	4.25e-227	-	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_00511	1.11e-164	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIGEKKFO_00512	1.12e-147	zmp2	-	-	O	-	-	-	Zinc-dependent metalloprotease
BIGEKKFO_00513	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
BIGEKKFO_00514	1.62e-158	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BIGEKKFO_00515	5.96e-69	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
BIGEKKFO_00516	9.43e-127	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTP diphosphatase
BIGEKKFO_00517	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIGEKKFO_00518	2.84e-264	yacL	-	-	S	-	-	-	domain protein
BIGEKKFO_00519	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIGEKKFO_00520	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
BIGEKKFO_00521	1.35e-92	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BIGEKKFO_00522	1.49e-177	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIGEKKFO_00523	1.75e-126	yacP	-	-	S	ko:K06962	-	ko00000	YacP-like NYN domain
BIGEKKFO_00524	1.12e-130	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Sigma-70 region 2
BIGEKKFO_00525	4.55e-31	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
BIGEKKFO_00526	1e-39	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
BIGEKKFO_00527	1.89e-128	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
BIGEKKFO_00528	2.81e-202	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_00529	9.76e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIGEKKFO_00530	2.69e-158	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
BIGEKKFO_00531	3.72e-105	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIGEKKFO_00532	2.76e-74	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
BIGEKKFO_00533	5.22e-229	-	-	-	F	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
BIGEKKFO_00534	1.5e-82	-	-	-	L	-	-	-	nuclease
BIGEKKFO_00535	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIGEKKFO_00536	5.82e-141	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
BIGEKKFO_00537	2.47e-253	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGEKKFO_00538	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGEKKFO_00539	8.42e-50	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
BIGEKKFO_00540	6.7e-141	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
BIGEKKFO_00541	7.57e-119	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
BIGEKKFO_00542	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIGEKKFO_00543	2.05e-62	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIGEKKFO_00544	6.22e-140	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIGEKKFO_00545	1.01e-51	yaaL	-	-	S	-	-	-	Protein of unknown function (DUF2508)
BIGEKKFO_00546	1.28e-152	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIGEKKFO_00547	1.39e-70	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
BIGEKKFO_00548	2.33e-239	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
BIGEKKFO_00549	8.46e-77	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
BIGEKKFO_00550	1.08e-212	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIGEKKFO_00551	3.17e-191	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
BIGEKKFO_00552	2.86e-245	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIGEKKFO_00553	1.47e-267	phnW	2.6.1.37	-	E	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	ko00000,ko00001,ko01000,ko01007	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily
BIGEKKFO_00554	2.8e-187	phnX	3.11.1.1	-	E	ko:K05306	ko00440,ko01100,ko01120,map00440,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the HAD-like hydrolase superfamily. PhnX family
BIGEKKFO_00555	3.33e-184	phnE1	-	-	U	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00556	6.51e-178	phnE2	-	-	U	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter permease
BIGEKKFO_00557	9.33e-177	phnC	3.6.3.28	-	P	ko:K02041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BIGEKKFO_00558	2.84e-241	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter
BIGEKKFO_00559	6.84e-167	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
BIGEKKFO_00560	4.66e-131	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
BIGEKKFO_00561	5.74e-108	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
BIGEKKFO_00562	7.63e-251	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIGEKKFO_00563	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
BIGEKKFO_00564	3.67e-154	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIGEKKFO_00565	2.38e-140	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00566	9.82e-55	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIGEKKFO_00567	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
BIGEKKFO_00568	0.0	ydaO	-	-	E	-	-	-	amino acid
BIGEKKFO_00569	7.29e-247	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	transferase
BIGEKKFO_00570	6.57e-199	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
BIGEKKFO_00571	3.7e-149	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
BIGEKKFO_00572	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
BIGEKKFO_00573	6.92e-163	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
BIGEKKFO_00574	1.27e-129	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIGEKKFO_00575	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
BIGEKKFO_00576	9.78e-257	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIGEKKFO_00577	1.82e-276	minJ	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
BIGEKKFO_00578	1.49e-170	phoP	-	-	K	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
BIGEKKFO_00579	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGEKKFO_00580	6.91e-201	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
BIGEKKFO_00581	2.22e-206	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
BIGEKKFO_00582	5.04e-200	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
BIGEKKFO_00583	9.78e-190	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
BIGEKKFO_00584	2.31e-179	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
BIGEKKFO_00585	1.55e-150	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
BIGEKKFO_00586	2.78e-65	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	positive regulation of macromolecule biosynthetic process
BIGEKKFO_00587	2.87e-71	yvlD	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
BIGEKKFO_00588	2.55e-225	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIGEKKFO_00589	1.04e-211	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIGEKKFO_00590	1.15e-234	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
BIGEKKFO_00591	1.13e-218	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
BIGEKKFO_00592	3.69e-159	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
BIGEKKFO_00593	0.0	nox	-	-	C	-	-	-	NADH oxidase
BIGEKKFO_00594	8.65e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
BIGEKKFO_00595	4.31e-141	yviA	-	-	S	-	-	-	Protein of unknown function (DUF421)
BIGEKKFO_00596	7.54e-99	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
BIGEKKFO_00597	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
BIGEKKFO_00598	8.48e-28	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
BIGEKKFO_00599	5.9e-170	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
BIGEKKFO_00600	0.0	nox2	-	-	S	-	-	-	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGEKKFO_00601	1.89e-134	aad	3.4.13.22	-	E	ko:K08641	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BIGEKKFO_00602	5.33e-268	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	transporter
BIGEKKFO_00603	9.45e-152	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
BIGEKKFO_00604	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
BIGEKKFO_00605	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
BIGEKKFO_00606	2.21e-113	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
BIGEKKFO_00607	7.5e-302	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
BIGEKKFO_00608	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
BIGEKKFO_00609	8.62e-114	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
BIGEKKFO_00610	1.71e-207	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
BIGEKKFO_00611	4.56e-243	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
BIGEKKFO_00612	1.21e-215	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
BIGEKKFO_00613	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_00614	1.55e-225	-	1.1.1.26	-	CH	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGEKKFO_00615	5.11e-133	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
BIGEKKFO_00617	1.14e-311	rpoN	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	Sigma-54 factor, core binding domain
BIGEKKFO_00618	5.75e-242	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	Putative sugar-binding domain
BIGEKKFO_00619	2.02e-245	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
BIGEKKFO_00620	1.31e-285	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
BIGEKKFO_00621	7.15e-179	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
BIGEKKFO_00622	0.0	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
BIGEKKFO_00623	5.11e-171	-	-	-	-	-	-	-	-
BIGEKKFO_00624	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
BIGEKKFO_00625	1.76e-43	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
BIGEKKFO_00626	1.1e-178	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Serine aminopeptidase, S33
BIGEKKFO_00627	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
BIGEKKFO_00628	2.4e-107	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
BIGEKKFO_00629	0.0	-	-	-	M	-	-	-	Domain of unknown function (DUF5011)
BIGEKKFO_00630	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_00631	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_00632	9.36e-171	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_00633	5.62e-137	-	-	-	-	-	-	-	-
BIGEKKFO_00634	1.98e-199	ycsE	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_00635	5.71e-174	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIGEKKFO_00636	1.23e-227	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
BIGEKKFO_00637	1.07e-104	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
BIGEKKFO_00638	2.52e-114	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_00639	7.18e-131	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
BIGEKKFO_00640	2.53e-198	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
BIGEKKFO_00641	1.47e-211	ysjB	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
BIGEKKFO_00642	6.24e-214	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
BIGEKKFO_00643	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
BIGEKKFO_00644	3.07e-119	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_00645	6.9e-157	-	-	-	S	-	-	-	Protein of unknown function (DUF1361)
BIGEKKFO_00646	8.33e-192	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIGEKKFO_00647	2.18e-182	ybbR	-	-	S	-	-	-	YbbR-like protein
BIGEKKFO_00648	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIGEKKFO_00649	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
BIGEKKFO_00650	3.15e-158	-	-	-	T	-	-	-	EAL domain
BIGEKKFO_00651	1.1e-187	-	3.1.3.23	-	S	ko:K07757	-	ko00000,ko01000	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_00652	1.21e-135	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00653	8.42e-263	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
BIGEKKFO_00654	3.38e-70	-	-	-	-	-	-	-	-
BIGEKKFO_00655	3.03e-96	-	-	-	-	-	-	-	-
BIGEKKFO_00656	1.73e-169	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
BIGEKKFO_00657	9.53e-195	-	-	-	G	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
BIGEKKFO_00658	8.8e-64	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIGEKKFO_00659	1.27e-283	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIGEKKFO_00660	3.69e-185	-	-	-	-	-	-	-	-
BIGEKKFO_00662	5.45e-94	spx1	-	-	P	ko:K16509	-	ko00000	ArsC family
BIGEKKFO_00663	3.88e-46	-	-	-	-	-	-	-	-
BIGEKKFO_00664	1.2e-116	-	-	-	V	-	-	-	VanZ like family
BIGEKKFO_00665	3.55e-313	-	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_00666	4.45e-226	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
BIGEKKFO_00667	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BIGEKKFO_00668	0.0	ppx3	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
BIGEKKFO_00669	2.72e-196	licD	-	-	M	ko:K07271	-	ko00000,ko01000	LicD family
BIGEKKFO_00670	6.16e-107	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00671	1.36e-27	-	-	-	-	-	-	-	-
BIGEKKFO_00672	1.79e-287	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
BIGEKKFO_00673	0.0	pox1	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_00674	3.3e-199	ribC1	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
BIGEKKFO_00675	0.0	pox2	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_00676	6.37e-232	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
BIGEKKFO_00677	1.23e-229	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
BIGEKKFO_00678	0.0	oatA	-	-	I	-	-	-	Acyltransferase
BIGEKKFO_00679	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
BIGEKKFO_00680	1.89e-90	-	-	-	O	-	-	-	OsmC-like protein
BIGEKKFO_00681	1.09e-60	-	-	-	-	-	-	-	-
BIGEKKFO_00682	0.0	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
BIGEKKFO_00683	6.12e-115	-	-	-	-	-	-	-	-
BIGEKKFO_00684	7.76e-193	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Phosphomethylpyrimidine kinase
BIGEKKFO_00685	7.48e-96	-	-	-	F	-	-	-	Nudix hydrolase
BIGEKKFO_00686	1.48e-27	-	-	-	-	-	-	-	-
BIGEKKFO_00687	4.95e-134	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase
BIGEKKFO_00688	2.02e-106	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
BIGEKKFO_00689	8.84e-18	-	3.2.1.14	GH18	-	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	-
BIGEKKFO_00690	1.01e-188	-	-	-	-	-	-	-	-
BIGEKKFO_00691	6.94e-146	gph1	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD hydrolase, family IA, variant
BIGEKKFO_00692	3.21e-268	aspC	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
BIGEKKFO_00693	1.03e-217	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGEKKFO_00694	1.28e-54	-	-	-	-	-	-	-	-
BIGEKKFO_00696	2.3e-172	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_00697	3.39e-190	glnH	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGEKKFO_00698	3.14e-140	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00699	1.27e-141	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_00700	2.1e-109	-	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
BIGEKKFO_00701	6.65e-198	-	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
BIGEKKFO_00702	0.0	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
BIGEKKFO_00703	1.83e-181	-	3.5.1.105	-	G	ko:K03478	-	ko00000,ko01000	YdjC-like protein
BIGEKKFO_00704	0.0	steT	-	-	E	ko:K03294	-	ko00000	amino acid
BIGEKKFO_00705	3.1e-96	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_00706	8.87e-191	-	-	-	S	-	-	-	Sulfite exporter TauE/SafE
BIGEKKFO_00707	3.08e-93	-	-	-	K	-	-	-	MarR family
BIGEKKFO_00708	4.58e-269	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_00709	2.93e-109	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
BIGEKKFO_00710	1.81e-128	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00711	5.95e-300	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIGEKKFO_00712	1.13e-102	rppH3	-	-	F	-	-	-	NUDIX domain
BIGEKKFO_00713	3.5e-64	sugE	-	-	U	ko:K11741	-	ko00000,ko02000	Multidrug resistance protein
BIGEKKFO_00714	1.61e-36	-	-	-	-	-	-	-	-
BIGEKKFO_00715	2.71e-165	pgm3	-	-	G	-	-	-	Phosphoglycerate mutase family
BIGEKKFO_00716	2.07e-161	gpm2	-	-	G	-	-	-	Phosphoglycerate mutase family
BIGEKKFO_00717	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
BIGEKKFO_00718	4.16e-227	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
BIGEKKFO_00719	2.84e-146	-	-	-	S	ko:K03975	-	ko00000	SNARE associated Golgi protein
BIGEKKFO_00720	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGEKKFO_00721	1.46e-211	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Nitronate monooxygenase
BIGEKKFO_00722	1.22e-227	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
BIGEKKFO_00723	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
BIGEKKFO_00724	1.08e-71	-	-	-	-	-	-	-	-
BIGEKKFO_00725	2.76e-83	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_00726	0.0	-	-	-	L	-	-	-	AAA domain
BIGEKKFO_00727	2.01e-149	XK27_07075	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_00728	1.85e-75	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGEKKFO_00729	4.73e-302	yceJ	-	-	EGP	ko:K08221	-	ko00000,ko02000	transporter
BIGEKKFO_00730	0.0	-	-	-	S	-	-	-	Cysteine-rich secretory protein family
BIGEKKFO_00731	3.61e-61	-	-	-	S	-	-	-	MORN repeat
BIGEKKFO_00732	0.0	XK27_09800	-	-	I	-	-	-	Acyltransferase family
BIGEKKFO_00733	1.81e-50	ydaS	-	-	S	-	-	-	Transglycosylase associated protein
BIGEKKFO_00734	1.95e-116	-	-	-	-	-	-	-	-
BIGEKKFO_00735	5.74e-32	-	-	-	-	-	-	-	-
BIGEKKFO_00736	1.1e-93	asp1	-	-	S	-	-	-	Asp23 family, cell envelope-related function
BIGEKKFO_00737	1.04e-94	asp2	-	-	S	-	-	-	Asp23 family, cell envelope-related function
BIGEKKFO_00738	1.31e-188	yisK	3.7.1.5, 4.1.1.68	-	Q	ko:K05921,ko:K16164	ko00350,ko01100,ko01120,ko01220,map00350,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Fumarylacetoacetate (FAA) hydrolase family
BIGEKKFO_00739	2.11e-211	yjdB	-	-	S	-	-	-	Domain of unknown function (DUF4767)
BIGEKKFO_00740	5.21e-62	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
BIGEKKFO_00741	2.66e-132	-	-	-	G	-	-	-	Glycogen debranching enzyme
BIGEKKFO_00742	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
BIGEKKFO_00743	0.0	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
BIGEKKFO_00744	3.37e-60	-	-	-	S	-	-	-	MazG-like family
BIGEKKFO_00745	2.31e-117	XK27_09665	-	-	G	ko:K15640	-	ko00000	Phosphoglycerate mutase family
BIGEKKFO_00746	0.0	-	-	-	M	-	-	-	MucBP domain
BIGEKKFO_00747	1.42e-08	-	-	-	-	-	-	-	-
BIGEKKFO_00748	1.27e-115	-	-	-	S	-	-	-	AAA domain
BIGEKKFO_00749	6.12e-179	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGEKKFO_00750	6.57e-125	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_00751	7.94e-220	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00752	0.0	-	-	-	C	-	-	-	FMN_bind
BIGEKKFO_00754	3.54e-105	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00755	1.41e-150	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIGEKKFO_00756	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
BIGEKKFO_00757	3.39e-255	asnA	6.3.1.1	-	F	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
BIGEKKFO_00758	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
BIGEKKFO_00759	2.98e-287	-	-	-	L	-	-	-	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIGEKKFO_00760	9.05e-55	-	-	-	-	-	-	-	-
BIGEKKFO_00761	4.95e-44	-	-	-	L	-	-	-	leucine-zipper of insertion element IS481
BIGEKKFO_00762	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
BIGEKKFO_00763	2.97e-212	rluD2	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
BIGEKKFO_00764	5.06e-68	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_00765	1.44e-179	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
BIGEKKFO_00766	1.94e-244	-	-	-	-	-	-	-	-
BIGEKKFO_00767	3.28e-278	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
BIGEKKFO_00768	8.44e-163	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
BIGEKKFO_00769	3.36e-132	-	-	-	K	-	-	-	FR47-like protein
BIGEKKFO_00770	1.5e-156	gpm5	-	-	G	-	-	-	Phosphoglycerate mutase family
BIGEKKFO_00771	3.33e-64	-	-	-	-	-	-	-	-
BIGEKKFO_00772	7.32e-247	-	-	-	I	-	-	-	alpha/beta hydrolase fold
BIGEKKFO_00773	0.0	xylP2	-	-	G	-	-	-	symporter
BIGEKKFO_00774	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIGEKKFO_00775	1.2e-281	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
BIGEKKFO_00776	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
BIGEKKFO_00777	2.41e-66	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
BIGEKKFO_00778	1.43e-155	azlC	-	-	E	-	-	-	branched-chain amino acid
BIGEKKFO_00779	1.75e-47	-	-	-	K	-	-	-	MerR HTH family regulatory protein
BIGEKKFO_00780	9.04e-179	-	-	-	-	-	-	-	-
BIGEKKFO_00781	2.72e-152	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
BIGEKKFO_00782	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
BIGEKKFO_00783	7.79e-112	-	-	-	K	-	-	-	MerR HTH family regulatory protein
BIGEKKFO_00784	1.36e-77	-	-	-	-	-	-	-	-
BIGEKKFO_00785	2.94e-155	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
BIGEKKFO_00786	1.78e-42	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
BIGEKKFO_00787	4.6e-169	-	-	-	S	-	-	-	Putative threonine/serine exporter
BIGEKKFO_00788	7.76e-100	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
BIGEKKFO_00789	6.72e-242	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
BIGEKKFO_00790	2.05e-153	-	-	-	I	-	-	-	phosphatase
BIGEKKFO_00791	3.88e-198	-	-	-	I	-	-	-	alpha/beta hydrolase fold
BIGEKKFO_00792	1.23e-128	yjcK	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGEKKFO_00793	1.7e-118	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_00794	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_00795	0.0	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
BIGEKKFO_00796	1.51e-152	dacB	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
BIGEKKFO_00797	1.11e-148	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
BIGEKKFO_00798	1.55e-292	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGEKKFO_00806	8.04e-101	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
BIGEKKFO_00807	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
BIGEKKFO_00808	1.36e-139	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00809	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGEKKFO_00810	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGEKKFO_00811	1e-147	comC	3.4.23.43	-	NOU	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	Bacterial Peptidase A24 N-terminal domain
BIGEKKFO_00812	4.19e-92	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIGEKKFO_00813	1.19e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
BIGEKKFO_00814	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIGEKKFO_00815	4.46e-66	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
BIGEKKFO_00816	4.34e-145	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIGEKKFO_00817	9.83e-141	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
BIGEKKFO_00818	2.27e-59	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
BIGEKKFO_00819	6.61e-193	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIGEKKFO_00820	1.85e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIGEKKFO_00821	3.59e-69	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BIGEKKFO_00822	5.46e-152	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIGEKKFO_00823	8.29e-100	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIGEKKFO_00824	1.11e-33	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
BIGEKKFO_00825	1.96e-54	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIGEKKFO_00826	2.98e-78	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIGEKKFO_00827	4.1e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIGEKKFO_00828	3.53e-123	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIGEKKFO_00829	4.99e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIGEKKFO_00830	2.14e-123	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIGEKKFO_00831	1.75e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIGEKKFO_00832	5.32e-109	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BIGEKKFO_00833	8.44e-34	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
BIGEKKFO_00834	1.32e-91	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
BIGEKKFO_00835	5.95e-300	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
BIGEKKFO_00836	1.84e-160	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
BIGEKKFO_00837	1.19e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIGEKKFO_00838	9.65e-79	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BIGEKKFO_00839	7.71e-82	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIGEKKFO_00840	2.19e-220	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGEKKFO_00841	7.76e-81	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
BIGEKKFO_00842	1.02e-233	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
BIGEKKFO_00843	1.41e-122	hepA	2.5.1.30	-	S	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase component I
BIGEKKFO_00844	5.37e-112	-	-	-	S	-	-	-	NusG domain II
BIGEKKFO_00845	0.0	ndh	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
BIGEKKFO_00846	3.19e-194	-	-	-	S	-	-	-	FMN_bind
BIGEKKFO_00847	1.07e-264	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
BIGEKKFO_00848	1.98e-197	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGEKKFO_00849	3.47e-212	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGEKKFO_00850	1.68e-184	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGEKKFO_00851	3.06e-194	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
BIGEKKFO_00852	4.58e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIGEKKFO_00853	8.98e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
BIGEKKFO_00854	1.41e-208	yitS	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
BIGEKKFO_00855	2.46e-235	-	-	-	S	-	-	-	Membrane
BIGEKKFO_00856	1.35e-261	-	-	-	C	-	-	-	Belongs to the LDH2 MDH2 oxidoreductase family
BIGEKKFO_00857	0.0	tkt2	2.2.1.1	-	H	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIGEKKFO_00858	2.45e-213	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIGEKKFO_00859	3.3e-235	aroF	2.5.1.54	-	E	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	DAHP synthetase I family
BIGEKKFO_00860	2.21e-254	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIGEKKFO_00861	0.0	-	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
BIGEKKFO_00862	1.51e-69	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
BIGEKKFO_00863	2.01e-147	-	4.2.1.2, 4.2.1.32	-	C	ko:K01676,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible hydration of fumarate to (S)- malate
BIGEKKFO_00864	6.08e-225	ttdA	4.2.1.32	-	C	ko:K03779	ko00630,map00630	ko00000,ko00001,ko01000	Fumarate hydratase (Fumerase)
BIGEKKFO_00865	1.55e-254	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_00866	7.77e-197	citG	2.4.2.52	-	H	ko:K05966	ko02020,map02020	ko00000,ko00001,ko01000	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
BIGEKKFO_00867	2.04e-170	mntB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGEKKFO_00868	3.54e-180	mtsB	-	-	U	ko:K19972,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
BIGEKKFO_00869	5.19e-223	mntA	-	-	P	ko:K19975,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
BIGEKKFO_00870	1.18e-66	-	-	-	-	-	-	-	-
BIGEKKFO_00871	1.53e-213	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
BIGEKKFO_00872	0.0	citP	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
BIGEKKFO_00873	8.69e-230	citR	-	-	K	-	-	-	sugar-binding domain protein
BIGEKKFO_00874	1.92e-264	mae	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme, NAD binding domain
BIGEKKFO_00875	5.31e-242	citC	6.2.1.22	-	H	ko:K01910	ko02020,map02020	ko00000,ko00001,ko01000	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BIGEKKFO_00876	1.23e-58	citD	-	-	C	ko:K01646	ko02020,map02020	ko00000,ko00001	Covalent carrier of the coenzyme of citrate lyase
BIGEKKFO_00877	9.11e-208	citE	4.1.3.34	-	G	ko:K01644	ko02020,map02020	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
BIGEKKFO_00878	0.0	citF	2.8.3.10	-	H	ko:K01643	ko02020,map02020	ko00000,ko00001,ko01000	Citrate (pro-3S)-lyase alpha chain
BIGEKKFO_00879	9.85e-186	-	-	-	L	ko:K07482	-	ko00000	PFAM Integrase, catalytic core
BIGEKKFO_00880	6.87e-33	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGEKKFO_00882	3.88e-20	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
BIGEKKFO_00883	6.03e-246	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
BIGEKKFO_00884	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
BIGEKKFO_00885	0.0	frdA	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
BIGEKKFO_00886	1.98e-122	citX	2.7.7.61	-	HI	ko:K05964	ko02020,map02020	ko00000,ko00001,ko01000	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BIGEKKFO_00887	4.54e-207	mleR2	-	-	K	-	-	-	LysR family transcriptional regulator
BIGEKKFO_00888	6.5e-215	mleR	-	-	K	-	-	-	LysR family
BIGEKKFO_00889	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
BIGEKKFO_00890	2.6e-212	mleP2	-	-	S	ko:K07088	-	ko00000	Sodium Bile acid symporter family
BIGEKKFO_00891	0.0	-	-	-	E	ko:K03294	-	ko00000	Amino Acid
BIGEKKFO_00892	4.37e-128	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
BIGEKKFO_00893	2.56e-34	-	-	-	-	-	-	-	-
BIGEKKFO_00894	0.0	-	-	-	S	ko:K06889	-	ko00000	Alpha beta
BIGEKKFO_00895	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
BIGEKKFO_00896	7.76e-234	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
BIGEKKFO_00897	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
BIGEKKFO_00898	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIGEKKFO_00899	1.89e-208	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
BIGEKKFO_00900	2.11e-233	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
BIGEKKFO_00901	8.5e-213	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
BIGEKKFO_00902	3.86e-235	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGEKKFO_00903	9.78e-146	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
BIGEKKFO_00904	5.76e-134	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
BIGEKKFO_00905	1.13e-120	yebE	-	-	S	-	-	-	UPF0316 protein
BIGEKKFO_00906	2.81e-279	purK2	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BIGEKKFO_00907	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
BIGEKKFO_00908	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIGEKKFO_00909	9.48e-263	camS	-	-	S	-	-	-	sex pheromone
BIGEKKFO_00910	5.11e-67	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIGEKKFO_00911	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
BIGEKKFO_00912	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIGEKKFO_00913	1.59e-242	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
BIGEKKFO_00914	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIGEKKFO_00915	5.56e-130	yobS	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_00916	0.0	yfgQ	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
BIGEKKFO_00917	7.06e-307	pts13C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00918	2.87e-215	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_00919	5.63e-196	gntR	-	-	K	-	-	-	rpiR family
BIGEKKFO_00920	1.9e-186	lys	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
BIGEKKFO_00921	7.34e-83	-	-	-	S	-	-	-	Domain of unknown function (DUF4828)
BIGEKKFO_00922	6.22e-43	cspP	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
BIGEKKFO_00923	7.89e-245	mocA	-	-	S	-	-	-	Oxidoreductase
BIGEKKFO_00924	5.62e-316	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
BIGEKKFO_00926	9.52e-97	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
BIGEKKFO_00927	9.65e-69	-	-	-	-	-	-	-	-
BIGEKKFO_00928	6.5e-97	-	-	-	K	-	-	-	Peptidase S24-like
BIGEKKFO_00929	1.56e-27	-	-	-	-	-	-	-	-
BIGEKKFO_00930	7.43e-76	-	-	-	S	-	-	-	ORF6C domain
BIGEKKFO_00934	3.32e-24	-	-	-	-	-	-	-	-
BIGEKKFO_00936	2.86e-186	-	-	-	S	-	-	-	Protein of unknown function (DUF1351)
BIGEKKFO_00937	1.62e-135	-	-	-	S	-	-	-	ERF superfamily
BIGEKKFO_00938	3.65e-87	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
BIGEKKFO_00939	7.19e-168	-	-	-	S	-	-	-	Putative HNHc nuclease
BIGEKKFO_00940	6.47e-54	-	-	-	L	-	-	-	Helix-turn-helix domain
BIGEKKFO_00941	1.14e-59	-	-	-	-	-	-	-	-
BIGEKKFO_00942	2.13e-25	-	-	-	-	-	-	-	-
BIGEKKFO_00944	3.24e-26	-	-	-	S	-	-	-	YopX protein
BIGEKKFO_00945	2.77e-48	-	-	-	-	-	-	-	-
BIGEKKFO_00947	1.88e-24	-	-	-	-	-	-	-	-
BIGEKKFO_00948	2.67e-83	-	-	-	S	-	-	-	Transcriptional regulator, RinA family
BIGEKKFO_00949	7.05e-190	-	-	-	S	ko:K06926	-	ko00000	AAA domain, putative AbiEii toxin, Type IV TA system
BIGEKKFO_00950	2.48e-18	-	-	-	S	-	-	-	RloB-like protein
BIGEKKFO_00952	1.24e-116	-	-	-	V	-	-	-	HNH nucleases
BIGEKKFO_00956	7.36e-94	-	-	-	L	-	-	-	Phage terminase small Subunit
BIGEKKFO_00957	0.0	-	-	-	S	-	-	-	Phage Terminase
BIGEKKFO_00959	4.78e-251	-	-	-	S	-	-	-	Phage portal protein
BIGEKKFO_00960	2.43e-138	-	-	-	S	-	-	-	Caudovirus prohead serine protease
BIGEKKFO_00961	9.12e-123	-	-	-	S	ko:K06904	-	ko00000	Phage capsid family
BIGEKKFO_00962	6.12e-46	-	-	-	-	-	-	-	-
BIGEKKFO_00963	4.71e-74	-	-	-	S	-	-	-	Phage head-tail joining protein
BIGEKKFO_00964	3.33e-88	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
BIGEKKFO_00965	4.01e-78	-	-	-	S	-	-	-	Protein of unknown function (DUF806)
BIGEKKFO_00966	2.46e-139	-	-	-	S	-	-	-	Phage tail tube protein
BIGEKKFO_00967	6.98e-78	-	-	-	S	-	-	-	Phage tail assembly chaperone proteins, TAC
BIGEKKFO_00968	0.0	-	-	-	D	-	-	-	domain protein
BIGEKKFO_00969	2.04e-286	-	-	-	S	-	-	-	Phage tail protein
BIGEKKFO_00970	0.0	-	-	-	S	-	-	-	Phage minor structural protein
BIGEKKFO_00971	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_00974	3.67e-73	-	-	-	-	-	-	-	-
BIGEKKFO_00975	8.3e-221	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
BIGEKKFO_00976	9.54e-39	-	-	-	S	-	-	-	Haemolysin XhlA
BIGEKKFO_00979	3.93e-99	-	-	-	T	-	-	-	Universal stress protein family
BIGEKKFO_00980	5.73e-316	pts14C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_00981	1.93e-210	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_00983	7.62e-97	-	-	-	-	-	-	-	-
BIGEKKFO_00984	2.9e-139	-	-	-	-	-	-	-	-
BIGEKKFO_00985	0.0	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
BIGEKKFO_00986	1.34e-280	pbpX	-	-	V	-	-	-	Beta-lactamase
BIGEKKFO_00987	4.75e-267	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
BIGEKKFO_00988	1.01e-199	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
BIGEKKFO_00989	3.98e-169	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_00990	4.96e-219	-	-	-	L	ko:K07482	-	ko00000	Transposase and inactivated derivatives, IS30 family
BIGEKKFO_00991	1.03e-51	-	-	GT2,GT4	M	ko:K07011,ko:K20444	-	ko00000,ko01000,ko01005,ko02000	PFAM Glycosyl transferase family 2
BIGEKKFO_00992	1.43e-33	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
BIGEKKFO_00994	3.14e-95	-	-	GT2	S	ko:K12990	ko02024,ko02025,map02024,map02025	ko00000,ko00001,ko01000,ko01003,ko01005	Glycosyl transferase family 2
BIGEKKFO_00995	1.38e-14	-	-	-	M	-	-	-	Glycosyl transferases group 1
BIGEKKFO_00996	2.25e-153	cps2I	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
BIGEKKFO_00997	2.92e-69	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIGEKKFO_00999	4.84e-16	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	AAA domain
BIGEKKFO_01001	1.08e-187	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BIGEKKFO_01002	1.21e-134	rfbC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
BIGEKKFO_01003	1.8e-249	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
BIGEKKFO_01004	5.23e-175	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
BIGEKKFO_01005	2.03e-123	-	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
BIGEKKFO_01006	1.84e-192	-	-	-	L	ko:K07482	-	ko00000	Integrase core domain
BIGEKKFO_01007	8.58e-220	-	-	-	L	ko:K07482	-	ko00000	Transposase and inactivated derivatives, IS30 family
BIGEKKFO_01008	3.06e-58	-	-	-	M	-	-	-	group 2 family protein
BIGEKKFO_01009	4.29e-47	-	-	-	M	-	-	-	Stealth protein CR3, conserved region 3
BIGEKKFO_01010	0.0	-	-	-	M	-	-	-	domain protein
BIGEKKFO_01011	2.18e-96	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_01012	0.0	cps1C	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
BIGEKKFO_01013	1.38e-155	rfbP	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
BIGEKKFO_01014	9.02e-70	-	-	-	-	-	-	-	-
BIGEKKFO_01015	1.04e-45	-	-	-	S	-	-	-	Protein of unknown function (DUF2922)
BIGEKKFO_01016	1.95e-41	-	-	-	-	-	-	-	-
BIGEKKFO_01017	1.35e-34	-	-	-	-	-	-	-	-
BIGEKKFO_01018	2.8e-130	-	-	-	K	-	-	-	DNA-templated transcription, initiation
BIGEKKFO_01019	6.63e-169	-	-	-	-	-	-	-	-
BIGEKKFO_01020	1.01e-181	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
BIGEKKFO_01021	6.62e-138	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
BIGEKKFO_01022	9.26e-171	lytE	-	-	M	-	-	-	NlpC/P60 family
BIGEKKFO_01023	3.97e-64	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGEKKFO_01024	8.39e-38	-	-	-	S	-	-	-	Antitoxin component of a toxin-antitoxin (TA) module
BIGEKKFO_01025	1.67e-166	pbpX	-	-	V	-	-	-	Beta-lactamase
BIGEKKFO_01026	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01027	7.3e-216	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
BIGEKKFO_01028	1.13e-257	yueF	-	-	S	-	-	-	AI-2E family transporter
BIGEKKFO_01029	6.04e-94	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Glycerol-3-phosphate cytidylyltransferase
BIGEKKFO_01030	7.89e-290	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	Gluconate
BIGEKKFO_01031	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
BIGEKKFO_01032	1.22e-218	gntZ	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
BIGEKKFO_01033	0.0	gshR3	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
BIGEKKFO_01034	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIGEKKFO_01035	3.9e-84	-	-	-	-	-	-	-	-
BIGEKKFO_01036	5.19e-247	-	-	-	-	-	-	-	-
BIGEKKFO_01037	1.49e-252	-	-	-	M	-	-	-	MucBP domain
BIGEKKFO_01038	1.36e-208	lysR5	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_01039	1.01e-172	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
BIGEKKFO_01040	3.85e-76	ywjH	-	-	S	-	-	-	Protein of unknown function (DUF1634)
BIGEKKFO_01041	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_01042	3.44e-210	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGEKKFO_01043	3.59e-241	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGEKKFO_01044	4.86e-258	oppD	-	-	P	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGEKKFO_01045	5.67e-231	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGEKKFO_01046	3.4e-85	-	-	-	K	-	-	-	Winged helix DNA-binding domain
BIGEKKFO_01047	2.5e-132	-	-	-	L	-	-	-	Integrase
BIGEKKFO_01048	0.0	clpE	-	-	O	ko:K03697	-	ko00000,ko03110	Belongs to the ClpA ClpB family
BIGEKKFO_01049	5.6e-41	-	-	-	-	-	-	-	-
BIGEKKFO_01050	1.24e-52	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
BIGEKKFO_01051	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIGEKKFO_01052	1.41e-285	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
BIGEKKFO_01053	2.04e-254	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
BIGEKKFO_01054	2.16e-241	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIGEKKFO_01055	1.88e-291	dacA2	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
BIGEKKFO_01056	3.5e-292	araT	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
BIGEKKFO_01057	1.56e-46	ykuJ	-	-	S	-	-	-	Protein of unknown function (DUF1797)
BIGEKKFO_01058	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
BIGEKKFO_01061	1.35e-55	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
BIGEKKFO_01073	1.88e-118	-	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Phosphoribosyl transferase domain
BIGEKKFO_01074	5.46e-238	-	-	-	P	ko:K06901	-	ko00000,ko02000	secondary active sulfate transmembrane transporter activity
BIGEKKFO_01075	1.25e-124	-	-	-	-	-	-	-	-
BIGEKKFO_01076	1.58e-122	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_01077	2.07e-200	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
BIGEKKFO_01079	2.19e-291	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
BIGEKKFO_01080	2.53e-240	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
BIGEKKFO_01081	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
BIGEKKFO_01082	7.89e-216	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine S-methyltransferase
BIGEKKFO_01083	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGEKKFO_01084	3.21e-155	-	-	-	-	-	-	-	-
BIGEKKFO_01085	2.78e-273	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIGEKKFO_01086	0.0	mdr	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_01087	4.36e-312	-	-	-	N	-	-	-	Cell shape-determining protein MreB
BIGEKKFO_01090	6.56e-22	-	-	-	N	-	-	-	Cell shape-determining protein MreB
BIGEKKFO_01091	0.0	-	-	-	S	-	-	-	Pfam Methyltransferase
BIGEKKFO_01092	0.0	tagE2	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGEKKFO_01093	0.0	tagE3	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGEKKFO_01094	9.32e-40	-	-	-	-	-	-	-	-
BIGEKKFO_01095	3.03e-122	mraW1	-	-	J	-	-	-	Putative rRNA methylase
BIGEKKFO_01096	1.03e-160	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
BIGEKKFO_01097	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
BIGEKKFO_01098	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
BIGEKKFO_01099	5.04e-176	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
BIGEKKFO_01100	9.06e-195	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BIGEKKFO_01101	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
BIGEKKFO_01102	2.16e-109	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
BIGEKKFO_01103	1.24e-259	ugpC	3.6.3.20	-	E	ko:K05816,ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
BIGEKKFO_01104	2.27e-221	ugpA	-	-	U	ko:K02025,ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_01105	3.05e-193	ugpE	-	-	G	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_01106	0.0	ugpB	-	-	G	ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGEKKFO_01107	5.45e-162	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
BIGEKKFO_01108	2.07e-155	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
BIGEKKFO_01109	3.55e-72	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
BIGEKKFO_01110	1.48e-315	XK27_06930	-	-	V	ko:K01421	-	ko00000	domain protein
BIGEKKFO_01112	8.55e-163	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
BIGEKKFO_01113	1.77e-200	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_01114	6.05e-225	-	-	-	K	ko:K01990	-	ko00000,ko00002,ko02000	LytTr DNA-binding domain
BIGEKKFO_01116	9.49e-196	mrsA1	1.8.4.11	-	O	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIGEKKFO_01117	5.2e-85	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_01118	5.48e-150	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_01119	1.55e-203	ydeD	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
BIGEKKFO_01120	6.61e-190	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_01121	7.83e-140	-	-	-	-	-	-	-	-
BIGEKKFO_01122	8.83e-285	pltK	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
BIGEKKFO_01123	9.01e-179	agrA	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
BIGEKKFO_01124	5.37e-74	-	-	-	-	-	-	-	-
BIGEKKFO_01125	4.56e-78	-	-	-	-	-	-	-	-
BIGEKKFO_01126	1.06e-146	XK27_07085	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_01127	2.2e-111	ohrR	-	-	K	ko:K18906	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_01128	1.25e-118	-	-	-	-	-	-	-	-
BIGEKKFO_01129	7.12e-62	-	-	-	-	-	-	-	-
BIGEKKFO_01130	0.0	uvrA2	-	-	L	-	-	-	ABC transporter
BIGEKKFO_01133	4.29e-87	-	-	-	-	-	-	-	-
BIGEKKFO_01134	9.03e-16	-	-	-	-	-	-	-	-
BIGEKKFO_01135	3.89e-237	-	-	-	-	-	-	-	-
BIGEKKFO_01136	4.91e-117	gtcA1	-	-	S	-	-	-	Teichoic acid glycosylation protein
BIGEKKFO_01137	8.01e-77	-	-	-	S	-	-	-	Protein of unknown function (DUF1516)
BIGEKKFO_01138	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
BIGEKKFO_01139	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIGEKKFO_01140	0.0	-	-	-	S	-	-	-	Protein conserved in bacteria
BIGEKKFO_01141	1.8e-292	sat	2.7.7.4	-	H	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms
BIGEKKFO_01142	2.24e-146	cysC	2.7.1.25	-	F	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
BIGEKKFO_01143	6.91e-234	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
BIGEKKFO_01144	0.0	astA	2.8.2.22	-	M	ko:K01023	-	ko00000,ko01000	Arylsulfotransferase Ig-like domain
BIGEKKFO_01145	0.0	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
BIGEKKFO_01146	2.69e-316	dinF	-	-	V	-	-	-	MatE
BIGEKKFO_01147	1.79e-42	-	-	-	-	-	-	-	-
BIGEKKFO_01150	7.02e-103	yybD	-	-	S	ko:K02348	-	ko00000	Acetyltransferase (GNAT) domain
BIGEKKFO_01151	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
BIGEKKFO_01152	2.91e-109	-	-	-	-	-	-	-	-
BIGEKKFO_01153	0.0	yhcA	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
BIGEKKFO_01154	1.26e-137	-	-	-	-	-	-	-	-
BIGEKKFO_01155	0.0	celR	-	-	K	-	-	-	PRD domain
BIGEKKFO_01156	1.34e-104	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
BIGEKKFO_01157	3.93e-67	lacF	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
BIGEKKFO_01158	4.9e-64	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_01159	3.02e-310	-	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_01160	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_01161	1.42e-270	-	-	-	EGP	ko:K08218	ko01501,map01501	ko00000,ko00001,ko00002,ko02000	Major facilitator Superfamily
BIGEKKFO_01162	3.47e-148	yciB	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
BIGEKKFO_01163	1.65e-46	dltC2	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
BIGEKKFO_01164	0.0	ydfD	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	Alanine-glyoxylate amino-transferase
BIGEKKFO_01165	3.29e-132	argO	-	-	S	ko:K06895	-	ko00000,ko02000	LysE type translocator
BIGEKKFO_01166	5.58e-271	arcT	-	-	E	-	-	-	Aminotransferase
BIGEKKFO_01167	2.07e-102	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
BIGEKKFO_01168	2.43e-18	-	-	-	-	-	-	-	-
BIGEKKFO_01169	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
BIGEKKFO_01170	9.94e-71	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
BIGEKKFO_01171	3.52e-293	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	Ser Thr phosphatase family protein
BIGEKKFO_01172	0.0	yhaN	-	-	L	-	-	-	AAA domain
BIGEKKFO_01173	1.03e-240	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGEKKFO_01174	3.71e-276	-	-	-	-	-	-	-	-
BIGEKKFO_01175	2.53e-140	-	-	-	M	-	-	-	Peptidase family S41
BIGEKKFO_01176	6.59e-227	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_01177	9.9e-144	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
BIGEKKFO_01178	0.0	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
BIGEKKFO_01179	3e-127	-	-	-	-	-	-	-	-
BIGEKKFO_01180	3.36e-100	-	2.4.2.6	-	F	ko:K08728	ko00240,map00240	ko00000,ko00001,ko01000	Nucleoside 2-deoxyribosyltransferase
BIGEKKFO_01181	1.78e-72	-	-	-	M	-	-	-	domain protein
BIGEKKFO_01182	1.29e-167	-	-	-	M	-	-	-	domain protein
BIGEKKFO_01183	7.13e-59	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
BIGEKKFO_01184	5.53e-67	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
BIGEKKFO_01185	1.81e-64	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
BIGEKKFO_01186	0.0	-	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
BIGEKKFO_01187	2.36e-252	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
BIGEKKFO_01188	0.0	-	-	-	L	-	-	-	ATPase domain of DNA mismatch repair MUTS family
BIGEKKFO_01189	0.0	-	-	-	L	-	-	-	MutS domain V
BIGEKKFO_01190	1.15e-235	ykoT	-	-	M	-	-	-	Glycosyl transferase family 2
BIGEKKFO_01191	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BIGEKKFO_01192	1.4e-90	-	-	-	S	-	-	-	NUDIX domain
BIGEKKFO_01193	0.0	-	-	-	S	-	-	-	membrane
BIGEKKFO_01194	4.26e-218	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIGEKKFO_01195	1.44e-109	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
BIGEKKFO_01196	3.6e-285	ribA	3.5.4.25, 4.1.99.12	-	H	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
BIGEKKFO_01197	1.23e-106	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
BIGEKKFO_01198	5.21e-137	-	-	-	S	ko:K09962	-	ko00000	Nucleotidyltransferase
BIGEKKFO_01199	3.39e-138	-	-	-	-	-	-	-	-
BIGEKKFO_01200	3.3e-151	crp2	-	-	K	ko:K10914,ko:K21562	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	helix_turn_helix, cAMP Regulatory protein
BIGEKKFO_01201	4.89e-146	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_01202	5.19e-309	npr	1.11.1.1	-	C	ko:K05910	-	ko00000,ko01000	NADH oxidase
BIGEKKFO_01203	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_01204	1.65e-80	-	-	-	-	-	-	-	-
BIGEKKFO_01205	1.37e-247	-	-	-	S	-	-	-	Fn3-like domain
BIGEKKFO_01206	1.9e-136	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_01207	5.76e-135	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_01208	1.09e-196	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
BIGEKKFO_01209	6.76e-73	-	-	-	-	-	-	-	-
BIGEKKFO_01210	3.6e-106	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	histidine triad
BIGEKKFO_01211	1.1e-174	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01212	1.11e-282	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_01213	7.24e-197	ytmP	-	-	M	-	-	-	Choline/ethanolamine kinase
BIGEKKFO_01214	4.7e-156	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
BIGEKKFO_01215	2.94e-71	ytzB	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
BIGEKKFO_01216	6.14e-147	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
BIGEKKFO_01217	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
BIGEKKFO_01218	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
BIGEKKFO_01219	3.04e-29	-	-	-	S	-	-	-	Virus attachment protein p12 family
BIGEKKFO_01220	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
BIGEKKFO_01221	2.87e-47	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA domain
BIGEKKFO_01222	1.1e-184	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
BIGEKKFO_01223	5.21e-311	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
BIGEKKFO_01224	1.11e-299	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIGEKKFO_01225	2.71e-108	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
BIGEKKFO_01226	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
BIGEKKFO_01227	7.63e-249	fecB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
BIGEKKFO_01228	1.14e-177	fecE	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
BIGEKKFO_01229	2.79e-212	fecD	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGEKKFO_01230	6.7e-107	-	-	-	C	-	-	-	Flavodoxin
BIGEKKFO_01231	6.26e-92	moaE	2.8.1.12	-	H	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	MoaE protein
BIGEKKFO_01232	7.86e-46	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	ThiS family
BIGEKKFO_01233	3.92e-248	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIGEKKFO_01234	1.98e-278	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	Transporter, major facilitator family protein
BIGEKKFO_01235	4.08e-78	-	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
BIGEKKFO_01236	7.79e-203	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix
BIGEKKFO_01237	6.92e-205	-	-	-	H	-	-	-	geranyltranstransferase activity
BIGEKKFO_01238	4.32e-233	-	-	-	-	-	-	-	-
BIGEKKFO_01239	3.67e-65	-	-	-	-	-	-	-	-
BIGEKKFO_01240	5.46e-152	nreC	-	-	K	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	PFAM regulatory protein LuxR
BIGEKKFO_01241	8.17e-242	nreB	2.7.13.3	-	F	ko:K07683	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Sensor histidine kinase
BIGEKKFO_01242	1.48e-98	-	2.7.13.3	-	T	ko:K07683,ko:K10851	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	phosphoenolpyruvate-protein phosphotransferase activity
BIGEKKFO_01243	8.84e-52	-	-	-	-	-	-	-	-
BIGEKKFO_01244	2.33e-128	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
BIGEKKFO_01245	1.08e-111	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
BIGEKKFO_01246	9.62e-116	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
BIGEKKFO_01247	2.12e-293	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	MoeA N-terminal region (domain I and II)
BIGEKKFO_01248	1.34e-108	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
BIGEKKFO_01249	7.89e-245	moeB	2.7.7.80	-	H	ko:K21029	ko04122,map04122	ko00000,ko00001,ko01000	ThiF family
BIGEKKFO_01250	0.0	narZ	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIGEKKFO_01251	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	4Fe-4S dicluster domain
BIGEKKFO_01252	6.94e-50	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	Nitrate reductase delta subunit
BIGEKKFO_01253	1.98e-65	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	Nitrate reductase delta subunit
BIGEKKFO_01254	1.89e-158	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase
BIGEKKFO_01255	1.6e-221	-	-	-	-	-	-	-	-
BIGEKKFO_01256	4.4e-97	-	-	-	-	-	-	-	-
BIGEKKFO_01257	4.4e-126	-	-	-	S	-	-	-	Protein of unknown function (DUF2975)
BIGEKKFO_01258	6.66e-39	yozG	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_01259	8.51e-155	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
BIGEKKFO_01260	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIGEKKFO_01261	2.63e-201	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
BIGEKKFO_01262	9.54e-134	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BIGEKKFO_01263	1.58e-117	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIGEKKFO_01264	0.0	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	replication initiation and membrane attachment
BIGEKKFO_01265	6.05e-221	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
BIGEKKFO_01266	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIGEKKFO_01267	2.37e-109	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIGEKKFO_01268	6.92e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
BIGEKKFO_01269	6.88e-73	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIGEKKFO_01270	7.63e-72	-	-	-	-	-	-	-	-
BIGEKKFO_01271	7.03e-307	-	-	-	L	ko:K07478	-	ko00000	AAA C-terminal domain
BIGEKKFO_01272	6.8e-250	qor	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
BIGEKKFO_01273	1.64e-83	ydeP	-	-	K	-	-	-	Transcriptional regulator, HxlR family
BIGEKKFO_01274	2.39e-175	racD	5.1.1.13	-	G	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
BIGEKKFO_01275	0.0	yijG	-	GT2	M	ko:K11936	ko02026,map02026	ko00000,ko00001,ko01000,ko01003,ko02000	Glycosyl transferase
BIGEKKFO_01276	6.32e-114	-	-	-	-	-	-	-	-
BIGEKKFO_01277	5.7e-127	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
BIGEKKFO_01278	3.13e-275	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
BIGEKKFO_01279	2.19e-67	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
BIGEKKFO_01280	4.19e-153	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIGEKKFO_01281	1.71e-149	yqeK	-	-	H	-	-	-	Hydrolase, HD family
BIGEKKFO_01282	1.06e-76	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
BIGEKKFO_01283	3.3e-180	yqeM	-	-	Q	-	-	-	Methyltransferase
BIGEKKFO_01284	2.05e-278	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
BIGEKKFO_01285	3.66e-127	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
BIGEKKFO_01286	2.15e-124	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
BIGEKKFO_01287	1.13e-225	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIGEKKFO_01288	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIGEKKFO_01289	7.66e-312	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
BIGEKKFO_01290	1.38e-155	csrR	-	-	K	-	-	-	response regulator
BIGEKKFO_01291	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGEKKFO_01292	7.87e-218	ubiA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
BIGEKKFO_01293	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	Putative exonuclease SbcCD, C subunit
BIGEKKFO_01294	2.36e-289	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
BIGEKKFO_01295	1.77e-122	-	-	-	S	-	-	-	SdpI/YhfL protein family
BIGEKKFO_01296	1.4e-208	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
BIGEKKFO_01297	1.37e-59	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
BIGEKKFO_01298	4.46e-179	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIGEKKFO_01299	1.72e-120	XK27_09705	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGEKKFO_01300	1.09e-83	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
BIGEKKFO_01301	6.88e-257	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIGEKKFO_01302	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
BIGEKKFO_01303	6.11e-249	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIGEKKFO_01304	7.5e-146	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
BIGEKKFO_01305	1.09e-105	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
BIGEKKFO_01306	9.72e-146	-	-	-	S	-	-	-	membrane
BIGEKKFO_01307	5.72e-99	-	-	-	K	-	-	-	LytTr DNA-binding domain
BIGEKKFO_01308	6.12e-72	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
BIGEKKFO_01309	0.0	-	-	-	S	-	-	-	membrane
BIGEKKFO_01310	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
BIGEKKFO_01311	5.33e-30	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
BIGEKKFO_01312	3.24e-132	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIGEKKFO_01313	1.01e-152	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
BIGEKKFO_01314	6.33e-46	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
BIGEKKFO_01315	2.6e-231	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
BIGEKKFO_01316	3e-23	pepE	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
BIGEKKFO_01317	1.2e-107	pepE	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
BIGEKKFO_01318	1.15e-89	yqhL	-	-	P	-	-	-	Rhodanese-like protein
BIGEKKFO_01319	1.44e-31	WQ51_02665	-	-	S	-	-	-	Protein of unknown function (DUF3042)
BIGEKKFO_01320	7.77e-179	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	phosphodiesterase
BIGEKKFO_01321	2.29e-225	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIGEKKFO_01322	7.79e-85	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	Transcriptional regulator
BIGEKKFO_01323	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
BIGEKKFO_01324	4.11e-206	-	-	-	-	-	-	-	-
BIGEKKFO_01325	1.34e-232	-	-	-	-	-	-	-	-
BIGEKKFO_01326	3.55e-127	-	-	-	S	-	-	-	Protein conserved in bacteria
BIGEKKFO_01327	1.87e-74	-	-	-	-	-	-	-	-
BIGEKKFO_01328	2.97e-41	-	-	-	-	-	-	-	-
BIGEKKFO_01331	9.81e-27	-	-	-	-	-	-	-	-
BIGEKKFO_01332	8.15e-125	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01333	1.55e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
BIGEKKFO_01334	7.97e-71	ysxB	-	-	J	ko:K07584	-	ko00000	Cysteine protease Prp
BIGEKKFO_01335	2.33e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
BIGEKKFO_01336	6.04e-249	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
BIGEKKFO_01337	1.43e-129	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIGEKKFO_01338	2.82e-95	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
BIGEKKFO_01339	2.82e-91	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIGEKKFO_01340	4.82e-194	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BIGEKKFO_01341	2.81e-313	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
BIGEKKFO_01342	7.55e-44	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
BIGEKKFO_01343	5.49e-205	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
BIGEKKFO_01344	4.49e-192	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
BIGEKKFO_01345	5.28e-100	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
BIGEKKFO_01346	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
BIGEKKFO_01347	4.51e-284	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01348	7.11e-135	opuCB	-	-	E	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_01349	3.8e-224	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
BIGEKKFO_01350	1.36e-136	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_01351	2.38e-72	-	-	-	-	-	-	-	-
BIGEKKFO_01352	6.96e-145	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
BIGEKKFO_01353	3.93e-41	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
BIGEKKFO_01354	5.04e-278	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIGEKKFO_01355	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIGEKKFO_01356	1.49e-224	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIGEKKFO_01357	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIGEKKFO_01358	1.62e-173	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
BIGEKKFO_01359	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
BIGEKKFO_01360	1.21e-209	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
BIGEKKFO_01361	2.22e-151	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
BIGEKKFO_01362	1.07e-159	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
BIGEKKFO_01363	1.61e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
BIGEKKFO_01364	7.09e-76	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
BIGEKKFO_01365	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
BIGEKKFO_01366	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIGEKKFO_01367	2.17e-244	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
BIGEKKFO_01368	3.33e-47	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIGEKKFO_01369	4.49e-167	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
BIGEKKFO_01370	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
BIGEKKFO_01371	2.85e-293	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
BIGEKKFO_01372	1.46e-77	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIGEKKFO_01373	9.38e-301	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIGEKKFO_01374	1.6e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
BIGEKKFO_01375	9.99e-53	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
BIGEKKFO_01376	2.24e-123	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIGEKKFO_01377	1.57e-179	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
BIGEKKFO_01378	3.15e-78	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
BIGEKKFO_01379	6.21e-68	-	-	-	-	-	-	-	-
BIGEKKFO_01380	0.0	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
BIGEKKFO_01381	3.69e-111	-	-	-	-	-	-	-	-
BIGEKKFO_01382	1.32e-77	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_01383	7.6e-153	-	-	-	C	-	-	-	nadph quinone reductase
BIGEKKFO_01384	2.33e-72	-	-	-	K	-	-	-	transcriptional regulator (AraC family)
BIGEKKFO_01385	3.25e-274	-	-	-	G	-	-	-	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
BIGEKKFO_01386	1.73e-136	gph	-	-	G	ko:K03292	-	ko00000	transporter
BIGEKKFO_01387	4.17e-86	-	-	-	GK	-	-	-	ROK family
BIGEKKFO_01388	5.02e-179	-	-	-	P	ko:K06610	-	ko00000,ko02000	Major Facilitator Superfamily
BIGEKKFO_01389	3.26e-176	ecsA_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
BIGEKKFO_01390	0.0	XK27_00765	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
BIGEKKFO_01391	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Anthranilate synthase component I, N terminal region
BIGEKKFO_01392	8.08e-135	trpG	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Peptidase C26
BIGEKKFO_01393	4.06e-224	trpD	2.4.2.18, 4.1.3.27	-	F	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIGEKKFO_01394	6.34e-161	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
BIGEKKFO_01395	1.57e-142	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
BIGEKKFO_01396	1.79e-287	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BIGEKKFO_01397	4.82e-183	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
BIGEKKFO_01398	1.02e-126	entB	-	-	Q	-	-	-	Isochorismatase family
BIGEKKFO_01399	3.53e-227	-	1.6.5.5	-	C	ko:K00344	-	ko00000,ko01000	Zinc-binding dehydrogenase
BIGEKKFO_01400	1.13e-87	ybbJ	-	-	K	-	-	-	Acetyltransferase (GNAT) family
BIGEKKFO_01401	1.89e-275	-	-	-	E	-	-	-	glutamate:sodium symporter activity
BIGEKKFO_01402	6.54e-272	hipO1	-	-	E	ko:K21613	-	ko00000,ko01000,ko01002	Peptidase family M20/M25/M40
BIGEKKFO_01403	8.04e-254	adhB	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
BIGEKKFO_01404	4.44e-79	-	-	-	S	-	-	-	Protein of unknown function (DUF1648)
BIGEKKFO_01406	6.84e-186	yneD	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_01407	1.55e-227	yneE	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01408	8.55e-99	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
BIGEKKFO_01409	8.02e-230	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIGEKKFO_01410	1.06e-48	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIGEKKFO_01411	2.97e-216	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
BIGEKKFO_01412	1.26e-162	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
BIGEKKFO_01413	6.27e-289	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
BIGEKKFO_01414	2.5e-94	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
BIGEKKFO_01415	8.45e-92	fabZ2	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
BIGEKKFO_01416	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
BIGEKKFO_01417	6.43e-203	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIGEKKFO_01418	4.82e-179	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	alpha subunit
BIGEKKFO_01419	1.88e-174	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
BIGEKKFO_01420	3.39e-127	-	-	-	H	ko:K06133	ko00770,map00770	ko00000,ko00001,ko01000	Belongs to the P-Pant transferase superfamily
BIGEKKFO_01421	7.34e-162	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
BIGEKKFO_01422	3.73e-207	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_01423	4.94e-114	ykhA	-	-	I	-	-	-	Thioesterase superfamily
BIGEKKFO_01424	1.54e-246	rsgA_2	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
BIGEKKFO_01425	6.05e-121	-	-	-	K	-	-	-	transcriptional regulator
BIGEKKFO_01426	0.0	-	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_01427	6.56e-193	-	-	-	O	-	-	-	Band 7 protein
BIGEKKFO_01428	1.58e-99	-	-	-	L	-	-	-	Pfam:Integrase_AP2
BIGEKKFO_01430	1.11e-17	-	-	-	-	-	-	-	-
BIGEKKFO_01431	4.28e-97	-	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family
BIGEKKFO_01435	1.01e-31	-	-	-	-	-	-	-	-
BIGEKKFO_01438	5.05e-52	-	-	-	S	-	-	-	protein disulfide oxidoreductase activity
BIGEKKFO_01441	8.07e-40	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGEKKFO_01442	4.61e-36	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGEKKFO_01450	4.68e-46	-	-	-	-	-	-	-	-
BIGEKKFO_01451	3.55e-118	-	-	-	S	-	-	-	AAA domain
BIGEKKFO_01452	1.99e-67	-	-	-	S	-	-	-	Protein of unknown function (DUF669)
BIGEKKFO_01453	1.38e-44	-	-	-	L	-	-	-	Domain of unknown function (DUF4373)
BIGEKKFO_01454	7.67e-66	-	-	-	-	-	-	-	-
BIGEKKFO_01455	9.83e-107	-	-	-	-	-	-	-	-
BIGEKKFO_01456	5.83e-87	rusA	-	-	L	-	-	-	Endodeoxyribonuclease RusA
BIGEKKFO_01459	3.12e-112	-	-	-	S	-	-	-	methyltransferase activity
BIGEKKFO_01461	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
BIGEKKFO_01462	5.1e-75	-	-	-	S	-	-	-	Transcriptional regulator, RinA family
BIGEKKFO_01465	3.55e-42	-	-	-	S	-	-	-	Helix-turn-helix of insertion element transposase
BIGEKKFO_01466	0.0	-	-	-	S	ko:K06909	-	ko00000	Phage terminase, large subunit
BIGEKKFO_01467	0.0	-	-	-	S	-	-	-	Phage portal protein, SPP1 Gp6-like
BIGEKKFO_01468	9.14e-213	-	-	-	S	-	-	-	Phage Mu protein F like protein
BIGEKKFO_01469	1.47e-107	-	-	-	S	-	-	-	Domain of unknown function (DUF4355)
BIGEKKFO_01470	1.44e-253	gpG	-	-	-	-	-	-	-
BIGEKKFO_01471	7.06e-81	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
BIGEKKFO_01472	4e-69	-	-	-	-	-	-	-	-
BIGEKKFO_01473	3.1e-119	-	-	-	-	-	-	-	-
BIGEKKFO_01474	1.22e-84	-	-	-	-	-	-	-	-
BIGEKKFO_01475	5.14e-137	-	-	-	-	-	-	-	-
BIGEKKFO_01476	6.69e-114	-	-	-	S	-	-	-	Phage tail assembly chaperone protein, TAC
BIGEKKFO_01478	0.0	-	-	-	D	-	-	-	domain protein
BIGEKKFO_01479	3.42e-182	-	-	-	S	-	-	-	phage tail
BIGEKKFO_01480	0.0	-	-	-	M	-	-	-	Prophage endopeptidase tail
BIGEKKFO_01481	1.92e-238	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
BIGEKKFO_01482	1.58e-140	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
BIGEKKFO_01485	1.05e-33	-	-	-	S	-	-	-	Phage uncharacterised protein (Phage_XkdX)
BIGEKKFO_01486	3.91e-160	-	-	-	M	-	-	-	hydrolase, family 25
BIGEKKFO_01487	5.7e-35	-	-	-	S	-	-	-	Haemolysin XhlA
BIGEKKFO_01488	5.67e-25	-	-	-	S	-	-	-	Bacteriophage holin
BIGEKKFO_01489	1.93e-05	-	-	-	-	-	-	-	-
BIGEKKFO_01491	2.4e-129	-	1.14.99.53	AA10	S	ko:K21713	-	ko00000,ko01000	Lytic polysaccharide mono-oxygenase, cellulose-degrading
BIGEKKFO_01492	1.54e-37	yafC	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_01493	2.1e-71	-	-	-	-	-	-	-	-
BIGEKKFO_01494	2.02e-39	-	-	-	-	-	-	-	-
BIGEKKFO_01495	1.69e-276	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
BIGEKKFO_01496	1.93e-144	-	1.14.99.53	AA10	S	ko:K21713	-	ko00000,ko01000	Lytic polysaccharide mono-oxygenase, cellulose-degrading
BIGEKKFO_01497	1.29e-63	ycnE	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
BIGEKKFO_01498	2.05e-55	-	-	-	-	-	-	-	-
BIGEKKFO_01499	6.05e-108	tspO	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	TspO/MBR family
BIGEKKFO_01500	5.28e-100	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
BIGEKKFO_01501	3.92e-87	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
BIGEKKFO_01502	7.27e-211	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
BIGEKKFO_01503	1.51e-48	-	-	-	-	-	-	-	-
BIGEKKFO_01504	5.79e-21	-	-	-	-	-	-	-	-
BIGEKKFO_01505	1.29e-54	-	-	-	S	-	-	-	transglycosylase associated protein
BIGEKKFO_01506	4e-40	-	-	-	S	-	-	-	CsbD-like
BIGEKKFO_01507	1.06e-53	-	-	-	-	-	-	-	-
BIGEKKFO_01508	0.0	pepD4	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
BIGEKKFO_01509	8.39e-38	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
BIGEKKFO_01510	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
BIGEKKFO_01511	1.04e-218	-	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
BIGEKKFO_01512	5.03e-182	-	-	-	U	ko:K10716	-	ko00000,ko02000	Ion channel
BIGEKKFO_01513	1.52e-67	-	-	-	-	-	-	-	-
BIGEKKFO_01514	1.94e-59	-	-	-	-	-	-	-	-
BIGEKKFO_01515	0.0	gabT	2.6.1.19, 5.1.1.21	-	E	ko:K00823,ko:K20708	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIGEKKFO_01516	0.0	-	-	-	E	ko:K03294	-	ko00000	Amino Acid
BIGEKKFO_01517	3.86e-192	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
BIGEKKFO_01518	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
BIGEKKFO_01519	2.06e-158	-	-	-	S	-	-	-	Domain of unknown function (DUF4767)
BIGEKKFO_01520	0.0	malT	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
BIGEKKFO_01521	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
BIGEKKFO_01522	9.62e-247	galM2	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
BIGEKKFO_01523	2.03e-249	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
BIGEKKFO_01524	1.77e-262	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
BIGEKKFO_01525	3.15e-230	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
BIGEKKFO_01526	1.48e-217	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
BIGEKKFO_01527	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
BIGEKKFO_01528	2.53e-107	ypmB	-	-	S	-	-	-	protein conserved in bacteria
BIGEKKFO_01529	2.55e-288	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
BIGEKKFO_01530	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
BIGEKKFO_01531	1.13e-165	dnaD	-	-	L	ko:K02086	-	ko00000	Replication initiation and membrane attachment
BIGEKKFO_01533	4.67e-238	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGEKKFO_01534	1.41e-141	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_01535	3.19e-203	metQ1	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
BIGEKKFO_01536	7.56e-109	-	-	-	T	-	-	-	Universal stress protein family
BIGEKKFO_01537	0.0	ftpA	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_01538	4.86e-235	ftpB	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGEKKFO_01539	2.4e-230	phnT	3.6.3.30	-	P	ko:K02010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_01540	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
BIGEKKFO_01541	3.6e-152	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
BIGEKKFO_01542	6.07e-142	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
BIGEKKFO_01543	9.98e-75	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
BIGEKKFO_01545	4.11e-282	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
BIGEKKFO_01546	1.26e-61	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_01547	7.37e-308	-	-	-	P	-	-	-	Major Facilitator Superfamily
BIGEKKFO_01548	4.17e-186	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
BIGEKKFO_01549	7.86e-96	-	-	-	S	-	-	-	SnoaL-like domain
BIGEKKFO_01550	9.03e-113	-	-	-	M	-	-	-	Glycosyltransferase group 2 family protein
BIGEKKFO_01551	3.57e-160	-	-	-	M	-	-	-	Glycosyltransferase, group 2 family protein
BIGEKKFO_01552	3.46e-267	mccF	-	-	V	-	-	-	LD-carboxypeptidase
BIGEKKFO_01553	1.66e-101	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_01554	1.23e-311	-	-	-	M	ko:K07273	-	ko00000	hydrolase, family 25
BIGEKKFO_01555	1.68e-233	-	-	-	V	-	-	-	LD-carboxypeptidase
BIGEKKFO_01556	1.71e-160	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
BIGEKKFO_01557	3.99e-158	-	-	-	P	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_01558	6.79e-249	-	-	-	-	-	-	-	-
BIGEKKFO_01559	3.69e-187	-	-	-	S	-	-	-	hydrolase activity, acting on ester bonds
BIGEKKFO_01560	1.47e-268	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	FAD dependent oxidoreductase
BIGEKKFO_01561	3.28e-87	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HI
BIGEKKFO_01562	5.04e-82	esbA	-	-	S	-	-	-	Family of unknown function (DUF5322)
BIGEKKFO_01563	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
BIGEKKFO_01564	1.65e-97	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIGEKKFO_01565	9.72e-225	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
BIGEKKFO_01566	1.9e-115	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIGEKKFO_01567	4.89e-263	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarA family
BIGEKKFO_01568	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
BIGEKKFO_01569	0.0	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
BIGEKKFO_01570	2.01e-145	-	-	-	G	-	-	-	Phosphoglycerate mutase family
BIGEKKFO_01571	1.9e-93	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
BIGEKKFO_01574	7.48e-61	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	Chloramphenicol acetyltransferase
BIGEKKFO_01575	4.03e-36	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	Chloramphenicol acetyltransferase
BIGEKKFO_01576	2.08e-92	-	-	-	S	-	-	-	LuxR family transcriptional regulator
BIGEKKFO_01577	1.19e-176	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2087)
BIGEKKFO_01578	5.59e-119	-	-	-	F	-	-	-	NUDIX domain
BIGEKKFO_01579	5.3e-209	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01580	1.6e-171	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGEKKFO_01581	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
BIGEKKFO_01582	1.97e-87	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01583	1.11e-205	-	-	-	S	-	-	-	EDD domain protein, DegV family
BIGEKKFO_01584	2.03e-100	yjcF	3.5.4.33, 4.4.1.8	-	K	ko:K02348,ko:K11991,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007,ko03016	protein acetylation
BIGEKKFO_01585	1.96e-168	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
BIGEKKFO_01586	3.15e-29	-	-	-	-	-	-	-	-
BIGEKKFO_01587	1.23e-63	-	-	-	-	-	-	-	-
BIGEKKFO_01588	6.64e-189	-	-	-	C	-	-	-	Domain of unknown function (DUF4931)
BIGEKKFO_01589	6e-268	pmrB	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_01591	1.33e-67	XK27_08430	-	-	S	-	-	-	Staphylococcal protein of unknown function (DUF960)
BIGEKKFO_01592	2.98e-166	yejC	-	-	S	-	-	-	Protein of unknown function (DUF1003)
BIGEKKFO_01593	1.5e-176	XK27_00890	-	-	S	ko:K08974	-	ko00000	Domain of unknown function (DUF368)
BIGEKKFO_01594	1.23e-311	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
BIGEKKFO_01595	1.16e-175	-	-	-	-	-	-	-	-
BIGEKKFO_01596	7.79e-78	-	-	-	-	-	-	-	-
BIGEKKFO_01597	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
BIGEKKFO_01598	8.23e-291	-	-	-	-	-	-	-	-
BIGEKKFO_01599	7.15e-165	tarI	2.7.7.40, 2.7.7.60	-	I	ko:K00991,ko:K21030	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate
BIGEKKFO_01600	1.47e-243	tarJ	1.1.1.137, 1.1.1.405	-	E	ko:K05352,ko:K21680	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate
BIGEKKFO_01601	9.61e-249	tarK	2.7.8.14, 2.7.8.46, 2.7.8.47	-	H	ko:K18704,ko:K21592	-	ko00000,ko01000	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
BIGEKKFO_01602	0.0	tarL	2.7.8.14, 2.7.8.47	-	H	ko:K18704	-	ko00000,ko01000	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
BIGEKKFO_01603	1.4e-122	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
BIGEKKFO_01604	1.6e-93	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_01605	7.91e-305	gshR1	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
BIGEKKFO_01606	3.22e-87	-	-	-	-	-	-	-	-
BIGEKKFO_01607	1.29e-285	-	-	-	M	-	-	-	Glycosyl transferase family group 2
BIGEKKFO_01608	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BIGEKKFO_01609	2.08e-203	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
BIGEKKFO_01610	1.07e-43	-	-	-	S	-	-	-	YozE SAM-like fold
BIGEKKFO_01611	9.17e-126	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIGEKKFO_01612	3.8e-105	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
BIGEKKFO_01613	3.91e-216	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
BIGEKKFO_01614	3.82e-228	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01615	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
BIGEKKFO_01616	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
BIGEKKFO_01617	2.4e-137	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
BIGEKKFO_01618	7.34e-217	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
BIGEKKFO_01619	0.0	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BIGEKKFO_01620	6.84e-121	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIGEKKFO_01621	1.5e-227	xerC	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family. XerC subfamily
BIGEKKFO_01622	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BIGEKKFO_01623	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIGEKKFO_01624	8.11e-203	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
BIGEKKFO_01625	1.67e-174	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIGEKKFO_01626	1.85e-206	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIGEKKFO_01627	5.99e-291	XK27_05470	-	-	E	-	-	-	Methionine synthase
BIGEKKFO_01628	1.22e-219	cpsY	-	-	K	-	-	-	Transcriptional regulator, LysR family
BIGEKKFO_01629	1.27e-222	-	-	-	L	ko:K07448	-	ko00000,ko02048	restriction endonuclease
BIGEKKFO_01630	1.75e-160	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
BIGEKKFO_01631	2.48e-252	XK27_00915	-	-	C	-	-	-	Luciferase-like monooxygenase
BIGEKKFO_01632	0.0	qacA	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_01633	0.0	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
BIGEKKFO_01634	9.33e-48	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
BIGEKKFO_01635	3.29e-147	ypmS	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2140)
BIGEKKFO_01636	5.91e-209	XK27_03630	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
BIGEKKFO_01637	2.03e-189	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
BIGEKKFO_01638	1.8e-119	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIGEKKFO_01639	4.04e-242	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIGEKKFO_01640	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01641	6.46e-109	-	-	-	-	-	-	-	-
BIGEKKFO_01642	3.65e-291	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
BIGEKKFO_01643	1.39e-185	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
BIGEKKFO_01644	1.29e-192	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
BIGEKKFO_01645	5.83e-291	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
BIGEKKFO_01646	5.57e-55	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
BIGEKKFO_01647	2.06e-314	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
BIGEKKFO_01648	1.98e-281	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
BIGEKKFO_01649	1.27e-151	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
BIGEKKFO_01650	1.25e-39	-	-	-	M	-	-	-	Lysin motif
BIGEKKFO_01651	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
BIGEKKFO_01652	3.38e-252	-	-	-	S	-	-	-	Helix-turn-helix domain
BIGEKKFO_01653	2.24e-126	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIGEKKFO_01654	2.69e-167	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
BIGEKKFO_01655	1.3e-132	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIGEKKFO_01656	5.83e-175	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIGEKKFO_01657	3.99e-92	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGEKKFO_01658	3.13e-211	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
BIGEKKFO_01659	7.94e-218	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
BIGEKKFO_01660	2.51e-98	ytwI	-	-	S	-	-	-	Protein of unknown function (DUF441)
BIGEKKFO_01661	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
BIGEKKFO_01662	8.69e-230	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
BIGEKKFO_01663	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
BIGEKKFO_01664	2.02e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
BIGEKKFO_01665	0.0	clpB	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
BIGEKKFO_01666	1.29e-298	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
BIGEKKFO_01667	1.61e-251	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIGEKKFO_01668	8.34e-165	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
BIGEKKFO_01669	3.38e-293	-	-	-	M	-	-	-	O-Antigen ligase
BIGEKKFO_01670	8.81e-166	drrB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGEKKFO_01671	3.85e-209	drrA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_01672	2.74e-112	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_01673	0.0	pps	2.7.9.2	-	H	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
BIGEKKFO_01674	1.94e-83	-	-	-	P	-	-	-	Rhodanese Homology Domain
BIGEKKFO_01675	7.43e-119	yetL	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGEKKFO_01676	4.16e-223	-	-	-	-	-	-	-	-
BIGEKKFO_01677	6.09e-281	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
BIGEKKFO_01678	1.51e-232	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
BIGEKKFO_01679	0.0	-	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
BIGEKKFO_01680	1.09e-310	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
BIGEKKFO_01681	1.54e-305	-	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Major Facilitator Superfamily
BIGEKKFO_01682	1.26e-101	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01683	2.46e-269	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
BIGEKKFO_01684	0.0	nox	-	-	P	-	-	-	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGEKKFO_01685	5.87e-177	-	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
BIGEKKFO_01686	9.89e-138	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	NUDIX domain
BIGEKKFO_01687	2.65e-93	spx2	-	-	P	ko:K16509	-	ko00000	ArsC family
BIGEKKFO_01688	1.56e-90	-	-	-	S	-	-	-	Protein of unknown function (DUF1722)
BIGEKKFO_01689	5.7e-146	-	-	-	GM	-	-	-	epimerase
BIGEKKFO_01690	0.0	-	-	-	S	-	-	-	Zinc finger, swim domain protein
BIGEKKFO_01691	1.97e-152	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	haloacid dehalogenase-like hydrolase
BIGEKKFO_01692	2.59e-129	thgA3	2.3.1.18, 2.3.1.79	-	S	ko:K00633,ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
BIGEKKFO_01693	1.01e-166	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGEKKFO_01694	1.12e-207	-	-	-	S	-	-	-	Alpha beta hydrolase
BIGEKKFO_01695	8.37e-145	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_01696	2.12e-102	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2255)
BIGEKKFO_01697	8.13e-207	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_01698	7.96e-223	cryZ	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	nadph quinone reductase
BIGEKKFO_01700	0.0	nox4	-	-	C	-	-	-	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGEKKFO_01701	4.51e-134	desR	-	-	K	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
BIGEKKFO_01702	1.91e-261	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGEKKFO_01703	7.05e-172	XK27_09830	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGEKKFO_01704	3.43e-203	yvfR	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_01706	6.64e-109	-	-	-	K	ko:K03827	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
BIGEKKFO_01707	9.55e-95	-	-	-	K	-	-	-	MarR family
BIGEKKFO_01708	1.49e-147	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
BIGEKKFO_01709	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01710	4.36e-208	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01711	2.11e-170	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGEKKFO_01712	5.21e-254	-	-	-	-	-	-	-	-
BIGEKKFO_01713	2.59e-256	-	-	-	-	-	-	-	-
BIGEKKFO_01714	8.19e-212	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01715	1.18e-85	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
BIGEKKFO_01716	1.74e-251	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
BIGEKKFO_01717	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
BIGEKKFO_01718	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
BIGEKKFO_01719	1.01e-222	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
BIGEKKFO_01720	2.84e-189	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
BIGEKKFO_01721	7.92e-217	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIGEKKFO_01722	1.15e-94	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
BIGEKKFO_01723	7.7e-110	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIGEKKFO_01724	4.81e-229	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
BIGEKKFO_01725	9.21e-94	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
BIGEKKFO_01726	1.09e-30	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
BIGEKKFO_01727	2.32e-194	yqfL	2.7.11.33, 2.7.4.28	-	F	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
BIGEKKFO_01728	5.18e-166	-	-	-	C	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGEKKFO_01729	1.66e-216	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIGEKKFO_01730	2.78e-280	tagB	2.7.8.44	-	M	ko:K21285	-	ko00000,ko01000	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
BIGEKKFO_01731	4.35e-204	yitT	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIGEKKFO_01732	3.71e-132	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIGEKKFO_01733	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
BIGEKKFO_01734	2.47e-310	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
BIGEKKFO_01735	2.83e-200	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-acetylmuramoyl-L-alanine amidase
BIGEKKFO_01736	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01737	3.23e-214	-	-	-	G	-	-	-	Fructosamine kinase
BIGEKKFO_01738	5.97e-151	yjcF	-	-	J	-	-	-	HAD-hyrolase-like
BIGEKKFO_01739	8.2e-102	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
BIGEKKFO_01740	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIGEKKFO_01741	2.56e-76	-	-	-	-	-	-	-	-
BIGEKKFO_01742	3.13e-172	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
BIGEKKFO_01743	6.83e-225	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
BIGEKKFO_01744	5.28e-146	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
BIGEKKFO_01745	4.78e-65	-	-	-	-	-	-	-	-
BIGEKKFO_01746	1e-66	-	-	-	-	-	-	-	-
BIGEKKFO_01749	3.34e-157	int7	-	-	L	-	-	-	Belongs to the 'phage' integrase family
BIGEKKFO_01750	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
BIGEKKFO_01751	3.95e-311	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BIGEKKFO_01752	5.75e-47	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
BIGEKKFO_01753	1.33e-296	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
BIGEKKFO_01754	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
BIGEKKFO_01755	8.59e-27	dltX	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
BIGEKKFO_01756	4.21e-266	pbpX2	-	-	V	-	-	-	Beta-lactamase
BIGEKKFO_01757	2.54e-266	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
BIGEKKFO_01758	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
BIGEKKFO_01759	2.24e-111	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIGEKKFO_01760	4.42e-248	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
BIGEKKFO_01761	1.19e-169	budA	4.1.1.5	-	Q	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
BIGEKKFO_01762	7.56e-242	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
BIGEKKFO_01763	5.17e-220	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIGEKKFO_01764	2.41e-113	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIGEKKFO_01765	1.72e-245	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
BIGEKKFO_01766	1.02e-296	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
BIGEKKFO_01767	1.63e-121	-	-	-	-	-	-	-	-
BIGEKKFO_01768	1.13e-269	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIGEKKFO_01769	1.43e-310	-	-	-	G	-	-	-	Major Facilitator
BIGEKKFO_01771	3.04e-71	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIGEKKFO_01772	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIGEKKFO_01773	3.28e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
BIGEKKFO_01774	2.95e-65	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
BIGEKKFO_01775	4.46e-275	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
BIGEKKFO_01776	9.74e-108	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
BIGEKKFO_01777	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIGEKKFO_01778	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
BIGEKKFO_01779	4.64e-294	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
BIGEKKFO_01780	1.13e-175	cdsA	2.7.7.41	-	I	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
BIGEKKFO_01781	3.17e-190	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIGEKKFO_01782	9.83e-113	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
BIGEKKFO_01783	3.01e-165	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
BIGEKKFO_01784	1.88e-194	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIGEKKFO_01785	6.33e-185	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
BIGEKKFO_01786	2.92e-172	-	-	-	S	ko:K07025	-	ko00000	Haloacid dehalogenase-like hydrolase
BIGEKKFO_01787	1.92e-239	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGEKKFO_01788	9.79e-65	yazA	-	-	L	ko:K07461	-	ko00000	GIY-YIG catalytic domain protein
BIGEKKFO_01789	3.65e-172	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
BIGEKKFO_01790	9.88e-152	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
BIGEKKFO_01791	3.96e-44	XK26_06720	-	-	S	ko:K09976	-	ko00000	Uncharacterised protein family (UPF0154)
BIGEKKFO_01792	7.68e-48	ynzC	-	-	S	-	-	-	UPF0291 protein
BIGEKKFO_01793	7.22e-149	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIGEKKFO_01794	1.01e-53	alkD	-	-	L	-	-	-	DNA alkylation repair enzyme
BIGEKKFO_01795	1.83e-121	-	-	-	-	-	-	-	-
BIGEKKFO_01796	2.54e-266	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
BIGEKKFO_01797	2.9e-91	-	-	-	-	-	-	-	-
BIGEKKFO_01798	3.81e-87	-	-	-	-	-	-	-	-
BIGEKKFO_01799	2.3e-226	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	Glycosyltransferase like family 2
BIGEKKFO_01800	6.27e-131	-	-	-	L	-	-	-	Helix-turn-helix domain
BIGEKKFO_01801	2.21e-281	ywtF_2	-	-	K	-	-	-	Cell envelope-related transcriptional attenuator domain
BIGEKKFO_01802	3.82e-184	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_01803	0.0	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_01804	2.38e-294	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Cell cycle protein
BIGEKKFO_01806	1.75e-43	-	-	-	-	-	-	-	-
BIGEKKFO_01807	1.39e-181	-	-	-	Q	-	-	-	Methyltransferase
BIGEKKFO_01808	2.84e-75	ybjQ	-	-	S	-	-	-	Belongs to the UPF0145 family
BIGEKKFO_01809	2.87e-270	-	-	-	EGP	-	-	-	Major facilitator Superfamily
BIGEKKFO_01810	7.9e-136	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_01811	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01812	1.52e-120	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIGEKKFO_01813	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
BIGEKKFO_01814	1.84e-67	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
BIGEKKFO_01815	1.95e-177	-	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_01816	2.05e-228	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
BIGEKKFO_01817	6.62e-62	-	-	-	-	-	-	-	-
BIGEKKFO_01818	1.55e-311	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIGEKKFO_01819	3.02e-175	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
BIGEKKFO_01820	1.73e-217	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
BIGEKKFO_01821	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase System
BIGEKKFO_01822	0.0	-	3.1.4.53	-	S	ko:K03651	ko00230,ko02025,map00230,map02025	ko00000,ko00001,ko01000	Calcineurin-like phosphoesterase
BIGEKKFO_01823	0.0	cps4J	-	-	S	-	-	-	MatE
BIGEKKFO_01824	2.05e-229	cps4I	-	-	M	-	-	-	Glycosyltransferase like family 2
BIGEKKFO_01825	5.23e-295	-	-	-	-	-	-	-	-
BIGEKKFO_01826	3.84e-235	cps4G	-	-	M	-	-	-	Glycosyltransferase Family 4
BIGEKKFO_01827	1.4e-259	cps4F	-	-	M	-	-	-	Glycosyl transferases group 1
BIGEKKFO_01828	3.31e-164	tuaA	-	-	M	-	-	-	Bacterial sugar transferase
BIGEKKFO_01829	8.71e-231	cps4D	5.1.3.2, 5.1.3.25	-	M	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
BIGEKKFO_01830	5.54e-189	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
BIGEKKFO_01831	4.97e-157	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
BIGEKKFO_01832	6.94e-161	epsB	-	-	M	-	-	-	biosynthesis protein
BIGEKKFO_01833	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
BIGEKKFO_01834	3.97e-173	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_01835	0.0	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
BIGEKKFO_01836	5.12e-31	-	-	-	-	-	-	-	-
BIGEKKFO_01837	6.47e-95	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
BIGEKKFO_01838	1.3e-65	-	-	-	S	-	-	-	mazG nucleotide pyrophosphohydrolase
BIGEKKFO_01839	1.12e-141	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
BIGEKKFO_01840	7.8e-300	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BIGEKKFO_01841	6.48e-288	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
BIGEKKFO_01842	4.38e-286	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIGEKKFO_01843	5.89e-204	-	-	-	S	-	-	-	Tetratricopeptide repeat
BIGEKKFO_01844	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIGEKKFO_01845	1.29e-200	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIGEKKFO_01846	4.48e-261	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_01847	2.9e-56	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIGEKKFO_01848	1.18e-46	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
BIGEKKFO_01849	8.43e-240	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
BIGEKKFO_01850	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
BIGEKKFO_01851	7.1e-116	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
BIGEKKFO_01852	1.27e-162	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
BIGEKKFO_01853	7.08e-250	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
BIGEKKFO_01854	2.56e-110	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIGEKKFO_01855	6.06e-132	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
BIGEKKFO_01856	1.91e-66	ylbG	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
BIGEKKFO_01857	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BIGEKKFO_01858	2.51e-261	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
BIGEKKFO_01859	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_01860	0.0	icaA	-	-	M	-	-	-	Glycosyl transferase family group 2
BIGEKKFO_01861	9.51e-135	-	-	-	-	-	-	-	-
BIGEKKFO_01862	6.34e-257	-	-	-	-	-	-	-	-
BIGEKKFO_01863	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
BIGEKKFO_01864	1.23e-177	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
BIGEKKFO_01865	2.64e-62	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
BIGEKKFO_01866	2.51e-208	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	L-malate dehydrogenase activity
BIGEKKFO_01867	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
BIGEKKFO_01868	3.35e-285	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
BIGEKKFO_01869	6.35e-230	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, C-terminal domain protein
BIGEKKFO_01870	1.21e-268	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
BIGEKKFO_01871	3.95e-132	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
BIGEKKFO_01872	6.45e-111	-	-	-	-	-	-	-	-
BIGEKKFO_01873	4.86e-45	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
BIGEKKFO_01874	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIGEKKFO_01875	2e-239	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
BIGEKKFO_01876	2.16e-39	-	-	-	-	-	-	-	-
BIGEKKFO_01877	2.62e-168	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
BIGEKKFO_01878	5.35e-220	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIGEKKFO_01879	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
BIGEKKFO_01880	5.87e-155	-	-	-	S	-	-	-	repeat protein
BIGEKKFO_01881	2.41e-157	pgm6	-	-	G	-	-	-	phosphoglycerate mutase
BIGEKKFO_01882	0.0	-	-	-	N	-	-	-	domain, Protein
BIGEKKFO_01883	1.22e-248	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF916)
BIGEKKFO_01884	5.92e-153	-	-	-	N	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_01885	4.64e-150	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	domain protein
BIGEKKFO_01886	9.64e-307	ktrB	-	-	P	ko:K03498	-	ko00000,ko02000	Potassium uptake protein
BIGEKKFO_01887	3.19e-285	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
BIGEKKFO_01888	4.94e-75	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
BIGEKKFO_01889	3.69e-278	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
BIGEKKFO_01890	5.85e-158	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIGEKKFO_01891	7.74e-47	-	-	-	-	-	-	-	-
BIGEKKFO_01892	3.51e-125	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
BIGEKKFO_01893	3.46e-242	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIGEKKFO_01894	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIGEKKFO_01895	6.52e-124	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA domain protein
BIGEKKFO_01896	2.06e-187	ylmH	-	-	S	-	-	-	S4 domain protein
BIGEKKFO_01897	6.45e-49	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	YGGT family
BIGEKKFO_01898	1.56e-93	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
BIGEKKFO_01899	9.39e-295	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIGEKKFO_01900	2.39e-310	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
BIGEKKFO_01901	2.34e-208	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
BIGEKKFO_01902	5e-253	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIGEKKFO_01903	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIGEKKFO_01904	2.05e-196	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIGEKKFO_01905	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
BIGEKKFO_01906	7.01e-76	ftsL	-	-	D	-	-	-	Cell division protein FtsL
BIGEKKFO_01907	2.12e-225	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
BIGEKKFO_01908	1.35e-100	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
BIGEKKFO_01909	3.22e-82	-	-	-	S	-	-	-	Protein of unknown function (DUF3397)
BIGEKKFO_01910	4.1e-223	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
BIGEKKFO_01911	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
BIGEKKFO_01912	1.66e-122	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
BIGEKKFO_01913	3.55e-147	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
BIGEKKFO_01914	2.17e-302	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
BIGEKKFO_01916	1.12e-207	rrmA	2.1.1.187	-	H	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase
BIGEKKFO_01917	4.82e-55	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIGEKKFO_01918	9.52e-264	XK27_05220	-	-	S	-	-	-	AI-2E family transporter
BIGEKKFO_01919	2.68e-75	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
BIGEKKFO_01920	5.57e-247	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
BIGEKKFO_01921	2.51e-150	cutC	-	-	P	ko:K06201	-	ko00000	Participates in the control of copper homeostasis
BIGEKKFO_01922	1.27e-221	yjbO	5.4.99.23	-	G	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
BIGEKKFO_01923	1.29e-193	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIGEKKFO_01924	9.08e-157	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
BIGEKKFO_01925	2.24e-148	yjbH	-	-	Q	-	-	-	Thioredoxin
BIGEKKFO_01926	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
BIGEKKFO_01927	2.34e-266	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
BIGEKKFO_01928	7.12e-170	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
BIGEKKFO_01929	9.28e-89	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
BIGEKKFO_01930	1.55e-163	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01931	2.06e-217	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_01932	3.28e-177	yhfI	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
BIGEKKFO_01933	1.08e-117	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
BIGEKKFO_01955	1.35e-55	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
BIGEKKFO_01956	1.29e-83	-	-	-	-	-	-	-	-
BIGEKKFO_01957	2e-98	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	general stress protein
BIGEKKFO_01958	5.16e-141	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIGEKKFO_01959	7.18e-153	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
BIGEKKFO_01960	4.69e-151	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
BIGEKKFO_01961	7.18e-189	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
BIGEKKFO_01962	1.96e-116	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
BIGEKKFO_01963	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
BIGEKKFO_01964	5.77e-151	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
BIGEKKFO_01965	0.0	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
BIGEKKFO_01966	4.7e-282	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIGEKKFO_01967	1.56e-236	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
BIGEKKFO_01969	6.46e-113	-	-	-	S	-	-	-	Prokaryotic N-terminal methylation motif
BIGEKKFO_01970	3.03e-27	-	-	-	-	ko:K02671	-	ko00000,ko02035,ko02044	-
BIGEKKFO_01971	3.53e-107	-	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	general secretion pathway protein
BIGEKKFO_01972	1.97e-72	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	competence protein ComGC
BIGEKKFO_01973	6.2e-242	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
BIGEKKFO_01974	1.27e-224	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
BIGEKKFO_01975	2.06e-205	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIGEKKFO_01976	2.21e-168	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
BIGEKKFO_01977	2.44e-65	-	-	-	S	ko:K09004	-	ko00000	DsrE/DsrF-like family
BIGEKKFO_01978	1.31e-209	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
BIGEKKFO_01979	5.44e-232	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
BIGEKKFO_01980	1.55e-275	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
BIGEKKFO_01981	9.11e-106	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_01982	1.6e-96	-	-	-	-	-	-	-	-
BIGEKKFO_01983	1.88e-75	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIGEKKFO_01984	2.31e-202	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
BIGEKKFO_01985	1.85e-286	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
BIGEKKFO_01986	2.29e-112	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
BIGEKKFO_01987	7.94e-114	ykuL	-	-	S	-	-	-	(CBS) domain
BIGEKKFO_01988	4.03e-125	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
BIGEKKFO_01989	8.49e-144	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIGEKKFO_01990	2.02e-47	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
BIGEKKFO_01991	2.26e-115	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
BIGEKKFO_01992	1.45e-161	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
BIGEKKFO_01993	3e-69	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
BIGEKKFO_01994	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
BIGEKKFO_01995	8.74e-49	-	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIGEKKFO_01996	1.31e-63	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
BIGEKKFO_01997	5.39e-96	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIGEKKFO_01998	5e-57	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
BIGEKKFO_01999	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIGEKKFO_02000	2.79e-316	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
BIGEKKFO_02001	8.32e-227	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
BIGEKKFO_02002	2.48e-276	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIGEKKFO_02003	1.32e-63	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
BIGEKKFO_02004	9.91e-289	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
BIGEKKFO_02005	5.87e-256	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIGEKKFO_02006	2.62e-239	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
BIGEKKFO_02007	2.83e-138	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
BIGEKKFO_02008	1.25e-119	-	-	-	-	-	-	-	-
BIGEKKFO_02009	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
BIGEKKFO_02010	1.35e-93	-	-	-	-	-	-	-	-
BIGEKKFO_02011	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIGEKKFO_02012	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIGEKKFO_02013	6.18e-197	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	YmdB-like protein
BIGEKKFO_02014	6.57e-291	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
BIGEKKFO_02015	2.43e-264	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BIGEKKFO_02016	7.4e-293	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
BIGEKKFO_02017	1.92e-127	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIGEKKFO_02018	5.74e-172	ymfM	-	-	S	ko:K15539	-	ko00000	Helix-turn-helix domain
BIGEKKFO_02019	0.0	ymfH	-	-	S	-	-	-	Peptidase M16
BIGEKKFO_02020	7.16e-296	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
BIGEKKFO_02021	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
BIGEKKFO_02022	2.61e-199	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
BIGEKKFO_02023	3.17e-149	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02024	1.89e-141	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
BIGEKKFO_02025	1.23e-187	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
BIGEKKFO_02026	3.81e-150	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
BIGEKKFO_02027	1.91e-114	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
BIGEKKFO_02028	3.76e-184	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
BIGEKKFO_02029	1.74e-211	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
BIGEKKFO_02030	1.15e-150	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
BIGEKKFO_02031	9.46e-315	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
BIGEKKFO_02032	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
BIGEKKFO_02033	5.9e-115	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIGEKKFO_02034	5.71e-302	gshF	6.3.2.2	-	H	ko:K01919,ko:K16786,ko:K16787	ko00270,ko00480,ko01100,ko02010,map00270,map00480,map01100,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the glutamate--cysteine ligase type 1 family
BIGEKKFO_02035	7.66e-292	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIGEKKFO_02036	2.22e-278	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
BIGEKKFO_02037	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIGEKKFO_02038	5.28e-105	yebR	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
BIGEKKFO_02039	2.15e-137	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIGEKKFO_02040	3.73e-150	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
BIGEKKFO_02041	4e-105	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
BIGEKKFO_02042	6.4e-142	-	-	-	S	-	-	-	Protein of unknown function (DUF1648)
BIGEKKFO_02043	4.54e-59	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_02044	4.84e-289	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
BIGEKKFO_02045	3.43e-55	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
BIGEKKFO_02046	5.82e-139	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose fructose sorbose family IID component
BIGEKKFO_02047	4.54e-132	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
BIGEKKFO_02048	3.79e-85	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
BIGEKKFO_02049	2.15e-118	-	-	-	K	-	-	-	Periplasmic binding proteins and sugar binding domain of LacI family
BIGEKKFO_02050	0.0	gshAB	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
BIGEKKFO_02051	4.2e-302	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
BIGEKKFO_02052	1.34e-52	-	-	-	-	-	-	-	-
BIGEKKFO_02053	2.37e-107	uspA	-	-	T	-	-	-	universal stress protein
BIGEKKFO_02054	1.2e-262	bla2	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
BIGEKKFO_02055	4.7e-207	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02056	0.0	glpQ3	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
BIGEKKFO_02057	6.54e-273	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
BIGEKKFO_02058	7.55e-242	-	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
BIGEKKFO_02059	1.33e-226	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
BIGEKKFO_02060	1.93e-214	hicD3	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
BIGEKKFO_02061	1.44e-189	metQ	-	-	M	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
BIGEKKFO_02062	2.1e-151	metI	-	-	U	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
BIGEKKFO_02063	2.24e-239	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGEKKFO_02064	3.2e-64	gcsH2	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	glycine cleavage
BIGEKKFO_02065	2.15e-280	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
BIGEKKFO_02066	2.54e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
BIGEKKFO_02067	1.52e-57	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
BIGEKKFO_02068	1.44e-230	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
BIGEKKFO_02069	1.68e-132	-	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGEKKFO_02070	2.94e-315	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIGEKKFO_02071	5.95e-74	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
BIGEKKFO_02072	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIGEKKFO_02073	1.3e-212	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIGEKKFO_02074	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIGEKKFO_02075	2.03e-118	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIGEKKFO_02076	5.41e-77	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIGEKKFO_02077	1.81e-37	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIGEKKFO_02078	4.82e-165	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
BIGEKKFO_02079	2.49e-294	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
BIGEKKFO_02080	7.81e-148	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIGEKKFO_02081	3.04e-297	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIGEKKFO_02082	4.39e-244	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
BIGEKKFO_02083	5.96e-205	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
BIGEKKFO_02084	1.88e-251	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIGEKKFO_02085	1.54e-141	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
BIGEKKFO_02086	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Domain of unknown function (DUF1727)
BIGEKKFO_02087	1.83e-175	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
BIGEKKFO_02088	4.95e-250	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
BIGEKKFO_02089	1.12e-246	ampC	-	-	V	-	-	-	Beta-lactamase
BIGEKKFO_02090	8.57e-41	-	-	-	-	-	-	-	-
BIGEKKFO_02091	1.9e-260	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
BIGEKKFO_02092	1.33e-77	-	-	-	-	-	-	-	-
BIGEKKFO_02093	5.37e-182	-	-	-	-	-	-	-	-
BIGEKKFO_02094	0.0	yfiC	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
BIGEKKFO_02095	0.0	ycfI	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02096	1.81e-85	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
BIGEKKFO_02097	2.96e-182	icaB	-	-	G	-	-	-	Polysaccharide deacetylase
BIGEKKFO_02099	1.83e-56	-	-	-	S	-	-	-	Bacteriophage holin
BIGEKKFO_02100	1.03e-46	-	-	-	S	-	-	-	Haemolysin XhlA
BIGEKKFO_02101	4.33e-253	lysA2	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
BIGEKKFO_02105	5.55e-261	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
BIGEKKFO_02106	1.13e-10	-	-	-	-	-	-	-	-
BIGEKKFO_02108	4.36e-81	-	-	-	S	-	-	-	Prophage endopeptidase tail
BIGEKKFO_02109	5.47e-81	-	-	-	S	-	-	-	Phage tail protein
BIGEKKFO_02110	0.0	-	-	-	S	-	-	-	peptidoglycan catabolic process
BIGEKKFO_02111	9.71e-139	-	-	-	S	-	-	-	Bacteriophage Gp15 protein
BIGEKKFO_02113	8.7e-123	-	-	-	-	-	-	-	-
BIGEKKFO_02114	7.59e-89	-	-	-	S	-	-	-	Minor capsid protein from bacteriophage
BIGEKKFO_02115	7.42e-60	-	-	-	S	-	-	-	Minor capsid protein
BIGEKKFO_02116	1.29e-72	-	-	-	S	-	-	-	Minor capsid protein
BIGEKKFO_02117	7.87e-12	-	-	-	-	-	-	-	-
BIGEKKFO_02118	6.76e-127	-	-	-	-	-	-	-	-
BIGEKKFO_02119	1.83e-88	-	-	-	S	-	-	-	Phage minor structural protein GP20
BIGEKKFO_02120	1.21e-217	-	-	-	S	-	-	-	Phage minor capsid protein 2
BIGEKKFO_02121	3.32e-301	-	-	-	S	-	-	-	Phage portal protein, SPP1 Gp6-like
BIGEKKFO_02122	0.0	-	-	-	S	-	-	-	Phage terminase large subunit
BIGEKKFO_02123	2.45e-51	-	-	-	S	-	-	-	Helix-turn-helix of insertion element transposase
BIGEKKFO_02124	8.54e-52	-	-	-	S	-	-	-	Beta protein
BIGEKKFO_02125	1.38e-54	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
BIGEKKFO_02130	3.86e-107	-	-	-	S	-	-	-	Phage transcriptional regulator, ArpU family
BIGEKKFO_02131	7.37e-08	-	-	-	-	-	-	-	-
BIGEKKFO_02132	3.86e-85	-	-	-	L	-	-	-	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BIGEKKFO_02133	4.51e-81	-	-	-	-	-	-	-	-
BIGEKKFO_02134	2.67e-66	-	-	-	-	-	-	-	-
BIGEKKFO_02135	3.09e-199	-	-	-	L	-	-	-	DnaD domain protein
BIGEKKFO_02136	5.13e-172	pi112	-	-	L	-	-	-	PDDEXK-like domain of unknown function (DUF3799)
BIGEKKFO_02137	9.3e-193	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
BIGEKKFO_02138	1.75e-91	-	-	-	-	-	-	-	-
BIGEKKFO_02141	1.56e-103	-	-	-	-	-	-	-	-
BIGEKKFO_02142	7.71e-71	-	-	-	-	-	-	-	-
BIGEKKFO_02144	5.55e-08	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02145	1.47e-22	-	-	-	K	ko:K22299	-	ko00000,ko03000	sequence-specific DNA binding
BIGEKKFO_02148	4.99e-232	-	-	-	S	ko:K07504	-	ko00000	Type I restriction enzyme R protein N terminus (HSDR_N)
BIGEKKFO_02153	6.54e-92	-	-	-	-	-	-	-	-
BIGEKKFO_02155	1.38e-85	-	-	-	S	-	-	-	Acyltransferase family
BIGEKKFO_02157	8.03e-280	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
BIGEKKFO_02159	1.98e-40	-	-	-	-	-	-	-	-
BIGEKKFO_02161	1.28e-51	-	-	-	-	-	-	-	-
BIGEKKFO_02162	9.28e-58	-	-	-	-	-	-	-	-
BIGEKKFO_02163	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_02164	1.27e-109	-	-	-	K	-	-	-	MarR family
BIGEKKFO_02165	0.0	-	-	-	D	-	-	-	nuclear chromosome segregation
BIGEKKFO_02166	0.0	inlJ	-	-	M	-	-	-	MucBP domain
BIGEKKFO_02167	6.58e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02168	3.26e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02169	1.56e-22	-	-	-	-	-	-	-	-
BIGEKKFO_02170	1.07e-26	-	-	-	-	-	-	-	-
BIGEKKFO_02171	9.35e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02172	9.35e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02173	9.35e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02174	2.16e-26	-	-	-	-	-	-	-	-
BIGEKKFO_02175	4.63e-24	-	-	-	-	-	-	-	-
BIGEKKFO_02176	0.0	-	3.6.3.44	-	P	ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter transmembrane region
BIGEKKFO_02177	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGEKKFO_02178	0.0	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02179	2.1e-33	-	-	-	-	-	-	-	-
BIGEKKFO_02180	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
BIGEKKFO_02181	2.51e-200	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
BIGEKKFO_02182	5.23e-277	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
BIGEKKFO_02183	0.0	yclK	-	-	T	-	-	-	Histidine kinase
BIGEKKFO_02184	3.41e-172	yclJ	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
BIGEKKFO_02185	2.12e-308	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
BIGEKKFO_02186	6.12e-51	XK27_08630	-	-	T	ko:K07166	-	ko00000	Belongs to the UPF0237 family
BIGEKKFO_02187	2.55e-218	-	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_02189	6.24e-120	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
BIGEKKFO_02190	1.31e-64	-	-	-	-	-	-	-	-
BIGEKKFO_02191	6.83e-274	yceI	-	-	EGP	ko:K08369	-	ko00000,ko02000	Major Facilitator
BIGEKKFO_02192	8.05e-178	-	-	-	F	-	-	-	NUDIX domain
BIGEKKFO_02193	2.68e-32	-	-	-	-	-	-	-	-
BIGEKKFO_02195	8.16e-207	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_02196	4.27e-223	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	NlpC/P60 family
BIGEKKFO_02197	4.17e-107	-	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	AsnC family
BIGEKKFO_02198	2.29e-48	-	-	-	-	-	-	-	-
BIGEKKFO_02199	1.11e-45	-	-	-	-	-	-	-	-
BIGEKKFO_02200	2.81e-278	-	-	-	T	-	-	-	diguanylate cyclase
BIGEKKFO_02201	0.0	-	-	-	S	-	-	-	ABC transporter, ATP-binding protein
BIGEKKFO_02202	9.24e-140	-	-	-	K	ko:K06977	-	ko00000	acetyltransferase
BIGEKKFO_02203	3.9e-105	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGEKKFO_02204	2.64e-61	-	-	-	-	-	-	-	-
BIGEKKFO_02205	0.0	nagE	2.7.1.193, 2.7.1.199, 2.7.1.208	-	G	ko:K02777,ko:K02802,ko:K02803,ko:K02804,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
BIGEKKFO_02206	5.54e-244	panE1	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIGEKKFO_02207	5.97e-210	-	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
BIGEKKFO_02208	8.69e-295	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
BIGEKKFO_02209	6.08e-312	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
BIGEKKFO_02210	8.88e-213	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to
BIGEKKFO_02211	2.79e-226	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_02212	6.03e-196	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGEKKFO_02213	1.32e-178	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02214	0.0	npr	1.11.1.1	-	C	ko:K05910	-	ko00000,ko01000	NADH oxidase
BIGEKKFO_02215	2.34e-203	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	Dehydrogenase
BIGEKKFO_02216	1.01e-176	yceF	-	-	P	ko:K05794	-	ko00000	membrane
BIGEKKFO_02217	6.8e-123	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
BIGEKKFO_02218	2.9e-253	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIGEKKFO_02219	5.11e-67	hisE	3.6.1.31	-	E	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosyl-ATP diphosphatase activity
BIGEKKFO_02220	2.49e-77	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIGEKKFO_02221	1.27e-172	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
BIGEKKFO_02222	6.84e-166	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIGEKKFO_02223	2.23e-142	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIGEKKFO_02224	2.46e-139	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
BIGEKKFO_02225	1.92e-299	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIGEKKFO_02226	1.69e-151	hisG	2.4.2.17	-	F	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
BIGEKKFO_02227	1.62e-275	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIGEKKFO_02228	1.12e-208	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphate phosphatase, HisJ
BIGEKKFO_02229	2.15e-282	ysaA	-	-	V	-	-	-	RDD family
BIGEKKFO_02230	7.28e-213	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
BIGEKKFO_02231	1.11e-72	-	-	-	S	-	-	-	Domain of unknown function (DU1801)
BIGEKKFO_02232	4.73e-118	rmeB	-	-	K	-	-	-	transcriptional regulator, MerR family
BIGEKKFO_02233	2.49e-190	-	-	-	GM	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_02234	4.54e-126	-	-	-	J	-	-	-	glyoxalase III activity
BIGEKKFO_02235	1.69e-255	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIGEKKFO_02236	4.7e-237	yxeI	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
BIGEKKFO_02237	1.45e-46	-	-	-	-	-	-	-	-
BIGEKKFO_02238	3.1e-144	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
BIGEKKFO_02239	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	MMPL family
BIGEKKFO_02240	0.0	-	-	-	M	-	-	-	domain protein
BIGEKKFO_02241	3e-98	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_02242	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
BIGEKKFO_02243	0.0	glpQ4	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	phosphodiesterase
BIGEKKFO_02244	4.01e-236	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
BIGEKKFO_02245	2.14e-183	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_02246	2.42e-248	-	-	-	S	-	-	-	domain, Protein
BIGEKKFO_02247	6.04e-217	-	-	-	S	-	-	-	Polyphosphate kinase 2 (PPK2)
BIGEKKFO_02248	2.57e-128	-	-	-	C	-	-	-	Nitroreductase family
BIGEKKFO_02249	1.23e-228	iunH1	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
BIGEKKFO_02250	1.03e-210	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIGEKKFO_02251	1.91e-198	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
BIGEKKFO_02252	1.79e-92	-	-	-	GK	-	-	-	ROK family
BIGEKKFO_02253	1.13e-112	-	-	-	GK	-	-	-	ROK family
BIGEKKFO_02254	2.08e-199	-	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIGEKKFO_02255	1.18e-172	rdrA	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
BIGEKKFO_02256	0.0	pflD	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
BIGEKKFO_02257	1.01e-226	-	-	-	K	-	-	-	sugar-binding domain protein
BIGEKKFO_02258	1.81e-160	mipB	2.2.1.2	-	H	ko:K00616,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase/Fructose-6-phosphate aldolase
BIGEKKFO_02259	2.13e-182	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_02260	2.89e-224	ccpB	-	-	K	-	-	-	lacI family
BIGEKKFO_02261	5.28e-203	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGEKKFO_02262	5e-227	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGEKKFO_02263	1.55e-253	yhhX	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGEKKFO_02264	0.0	nhaP2	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
BIGEKKFO_02265	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIGEKKFO_02266	9.38e-139	pncA	-	-	Q	-	-	-	Isochorismatase family
BIGEKKFO_02267	2.66e-172	-	-	-	-	-	-	-	-
BIGEKKFO_02268	5e-162	skfE	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_02269	8.34e-86	lexA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator, GntR family
BIGEKKFO_02270	7.2e-61	-	-	-	S	-	-	-	Enterocin A Immunity
BIGEKKFO_02271	3.25e-223	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
BIGEKKFO_02272	0.0	pepF2	-	-	E	-	-	-	Oligopeptidase F
BIGEKKFO_02273	1.4e-95	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_02274	1.08e-209	-	-	-	-	-	-	-	-
BIGEKKFO_02275	1.28e-77	-	-	-	-	-	-	-	-
BIGEKKFO_02276	4.83e-64	-	-	-	-	-	-	-	-
BIGEKKFO_02277	0.0	spxB	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_02278	1.17e-88	-	-	-	-	-	-	-	-
BIGEKKFO_02279	6.89e-186	-	-	-	S	ko:K06889	-	ko00000	Dienelactone hydrolase family
BIGEKKFO_02280	9.89e-74	ytpP	-	-	CO	-	-	-	Thioredoxin
BIGEKKFO_02281	2.24e-261	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Cys/Met metabolism PLP-dependent enzyme
BIGEKKFO_02282	3.89e-62	-	-	-	-	-	-	-	-
BIGEKKFO_02283	1.57e-71	-	-	-	-	-	-	-	-
BIGEKKFO_02284	6.94e-106	-	-	-	S	-	-	-	Protein of unknown function (DUF2798)
BIGEKKFO_02285	4.05e-98	-	-	-	-	-	-	-	-
BIGEKKFO_02286	4.15e-78	-	-	-	-	-	-	-	-
BIGEKKFO_02287	4.26e-250	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
BIGEKKFO_02288	0.0	acm2	3.2.1.17	-	NU	ko:K01185	-	ko00000,ko01000	Bacterial SH3 domain
BIGEKKFO_02289	1.63e-95	-	-	-	G	ko:K02744	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
BIGEKKFO_02290	3.82e-188	agaD	-	-	G	ko:K02747,ko:K02796,ko:K10986	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
BIGEKKFO_02291	5.2e-185	-	-	-	G	ko:K02746,ko:K10985	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
BIGEKKFO_02292	4.28e-112	-	2.7.1.191	-	K	ko:K02745,ko:K02794,ko:K10984	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
BIGEKKFO_02293	5.87e-166	-	-	-	K	ko:K03710	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
BIGEKKFO_02294	2.51e-103	uspA3	-	-	T	-	-	-	universal stress protein
BIGEKKFO_02295	1.84e-205	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
BIGEKKFO_02296	4.05e-64	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGEKKFO_02297	1.38e-30	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
BIGEKKFO_02298	6.19e-284	-	-	-	M	-	-	-	Glycosyl transferases group 1
BIGEKKFO_02299	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
BIGEKKFO_02300	1.52e-204	-	-	-	S	-	-	-	Putative esterase
BIGEKKFO_02301	3.53e-169	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_02302	4.75e-117	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIGEKKFO_02303	6.08e-179	-	-	-	-	-	-	-	-
BIGEKKFO_02304	4.85e-151	yagB	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGEKKFO_02305	8.05e-179	rrp8	-	-	K	-	-	-	LytTr DNA-binding domain
BIGEKKFO_02306	1.7e-118	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
BIGEKKFO_02307	2.2e-79	-	-	-	-	-	-	-	-
BIGEKKFO_02308	2.61e-96	hsp2	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
BIGEKKFO_02309	2.97e-76	-	-	-	-	-	-	-	-
BIGEKKFO_02310	0.0	yhdP	-	-	S	-	-	-	Transporter associated domain
BIGEKKFO_02311	1.18e-114	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
BIGEKKFO_02312	0.0	nhaP3	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
BIGEKKFO_02313	1.17e-270	yttB	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_02314	2.84e-82	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_02315	2.19e-220	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
BIGEKKFO_02316	4.71e-74	-	-	-	S	-	-	-	SdpI/YhfL protein family
BIGEKKFO_02317	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIGEKKFO_02318	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	Bacterial regulatory proteins, gntR family
BIGEKKFO_02319	1.02e-277	araT2	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
BIGEKKFO_02320	1.84e-204	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIGEKKFO_02321	3.59e-26	-	-	-	-	-	-	-	-
BIGEKKFO_02322	2.09e-169	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
BIGEKKFO_02323	1.11e-205	mleR	-	-	K	-	-	-	LysR family
BIGEKKFO_02324	1.29e-148	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_02325	1.57e-123	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
BIGEKKFO_02326	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
BIGEKKFO_02327	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
BIGEKKFO_02328	5.46e-218	oroP	-	-	S	ko:K09936	ko02024,map02024	ko00000,ko00001,ko02000	Putative inner membrane exporter, YdcZ
BIGEKKFO_02329	6.64e-146	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIGEKKFO_02330	1.09e-161	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
BIGEKKFO_02331	4.95e-217	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
BIGEKKFO_02332	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
BIGEKKFO_02333	3.36e-272	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
BIGEKKFO_02334	7.96e-309	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
BIGEKKFO_02335	1.22e-220	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
BIGEKKFO_02336	7.13e-123	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIGEKKFO_02337	0.0	pucR_2	-	-	QT	ko:K09684	-	ko00000,ko03000	Purine catabolism regulatory protein-like family
BIGEKKFO_02338	4.41e-305	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
BIGEKKFO_02339	5.67e-280	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	Permease family
BIGEKKFO_02340	4.71e-208	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02341	1.25e-199	-	-	-	T	-	-	-	EAL domain
BIGEKKFO_02342	1.85e-121	-	-	-	-	-	-	-	-
BIGEKKFO_02343	0.0	yijG	-	GT2	M	ko:K11936	ko02026,map02026	ko00000,ko00001,ko01000,ko01003,ko02000	Glycosyl transferase
BIGEKKFO_02344	6.39e-158	-	-	-	E	-	-	-	Methionine synthase
BIGEKKFO_02345	6.66e-281	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
BIGEKKFO_02346	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
BIGEKKFO_02347	1.79e-131	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIGEKKFO_02348	1.04e-243	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
BIGEKKFO_02349	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIGEKKFO_02350	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGEKKFO_02351	2.82e-163	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGEKKFO_02352	1.17e-55	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGEKKFO_02353	3.95e-167	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
BIGEKKFO_02354	6.77e-269	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIGEKKFO_02355	3.77e-104	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIGEKKFO_02356	7.9e-305	XK27_09615	1.5.1.36	-	S	ko:K19784,ko:K22393	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	reductase
BIGEKKFO_02357	9.92e-143	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
BIGEKKFO_02358	1.16e-242	lplL	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Bacterial lipoate protein ligase C-terminus
BIGEKKFO_02359	2.04e-189	ptp3	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
BIGEKKFO_02360	3.44e-152	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	Eukaryotic-type carbonic anhydrase
BIGEKKFO_02361	4.15e-191	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_02362	3.7e-233	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	Asparaginase
BIGEKKFO_02363	2.05e-178	cysA	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02364	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
BIGEKKFO_02365	4.76e-56	-	-	-	-	-	-	-	-
BIGEKKFO_02366	8.2e-81	-	-	-	K	-	-	-	Transcriptional regulator, GntR family
BIGEKKFO_02367	7.89e-212	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02368	5.66e-189	-	-	-	-	-	-	-	-
BIGEKKFO_02369	2.7e-104	usp5	-	-	T	-	-	-	universal stress protein
BIGEKKFO_02370	1.08e-47	-	-	-	-	-	-	-	-
BIGEKKFO_02371	4.02e-95	gtcA	-	-	S	-	-	-	Teichoic acid glycosylation protein
BIGEKKFO_02372	1.02e-113	-	-	-	-	-	-	-	-
BIGEKKFO_02373	1.98e-65	-	-	-	-	-	-	-	-
BIGEKKFO_02374	4.79e-13	-	-	-	-	-	-	-	-
BIGEKKFO_02375	3.03e-299	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
BIGEKKFO_02376	1.16e-110	-	-	-	F	-	-	-	belongs to the nudix hydrolase family
BIGEKKFO_02377	1.52e-151	-	-	-	-	-	-	-	-
BIGEKKFO_02378	1.21e-69	-	-	-	-	-	-	-	-
BIGEKKFO_02379	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_02380	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
BIGEKKFO_02381	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
BIGEKKFO_02382	4.65e-186	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
BIGEKKFO_02383	2.96e-41	-	-	-	S	-	-	-	Pentapeptide repeats (8 copies)
BIGEKKFO_02384	1.76e-143	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
BIGEKKFO_02385	2.19e-130	-	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
BIGEKKFO_02386	2.26e-91	-	-	-	FG	-	-	-	Scavenger mRNA decapping enzyme C-term binding
BIGEKKFO_02387	1.62e-173	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
BIGEKKFO_02388	3.94e-49	XK27_01315	-	-	S	-	-	-	Protein of unknown function (DUF2829)
BIGEKKFO_02389	3.48e-269	ybhE	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
BIGEKKFO_02390	4.43e-294	-	-	-	S	-	-	-	Sterol carrier protein domain
BIGEKKFO_02391	1.66e-287	-	-	-	EGP	-	-	-	Transmembrane secretion effector
BIGEKKFO_02392	3.74e-115	yrxA	-	-	S	ko:K07105	-	ko00000	3H domain
BIGEKKFO_02393	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIGEKKFO_02394	2.13e-152	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_02395	9.76e-234	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_02396	4.29e-173	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
BIGEKKFO_02397	0.0	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
BIGEKKFO_02398	0.0	pbg4	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02399	0.0	pbg5	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02400	6.7e-74	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose Cellobiose specific IIA subunit
BIGEKKFO_02401	1.86e-64	pts20B	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_02402	9.05e-169	gntR	-	-	K	ko:K03489	-	ko00000,ko03000	UTRA
BIGEKKFO_02403	1.4e-181	epsV	-	-	S	-	-	-	glycosyl transferase family 2
BIGEKKFO_02404	1.75e-156	pgm7	-	-	G	-	-	-	Phosphoglycerate mutase family
BIGEKKFO_02405	7.63e-107	-	-	-	-	-	-	-	-
BIGEKKFO_02406	5.06e-196	-	-	-	S	-	-	-	hydrolase
BIGEKKFO_02407	7.17e-234	ykpB	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIGEKKFO_02408	4.64e-203	-	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_02409	6.83e-225	serA1	-	-	EH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
BIGEKKFO_02410	6.27e-131	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
BIGEKKFO_02411	0.0	-	-	-	-	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	-
BIGEKKFO_02412	1.17e-101	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
BIGEKKFO_02413	0.0	-	-	-	M	-	-	-	Domain of unknown function (DUF5011)
BIGEKKFO_02414	0.0	-	-	-	M	-	-	-	Bacterial surface protein 26-residue PARCEL repeat (3 repeats)
BIGEKKFO_02415	4.3e-44	-	-	-	-	-	-	-	-
BIGEKKFO_02416	2.89e-165	aroC1	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Type I 3-dehydroquinase
BIGEKKFO_02417	0.0	ycaM	-	-	E	-	-	-	amino acid
BIGEKKFO_02418	2.45e-101	-	-	-	K	-	-	-	Winged helix DNA-binding domain
BIGEKKFO_02419	1.42e-212	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	Oxidoreductase, aldo keto reductase family protein
BIGEKKFO_02420	2.95e-207	akr5f	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
BIGEKKFO_02421	1.3e-209	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_02423	1.35e-55	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
BIGEKKFO_02424	1.97e-110	-	-	-	S	-	-	-	Pfam:DUF3816
BIGEKKFO_02425	1.21e-306	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIGEKKFO_02426	5.16e-143	-	-	-	-	-	-	-	-
BIGEKKFO_02427	1.08e-229	-	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
BIGEKKFO_02428	3.84e-185	-	-	-	S	-	-	-	Peptidase_C39 like family
BIGEKKFO_02429	1.72e-119	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
BIGEKKFO_02430	2.28e-148	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
BIGEKKFO_02431	9.38e-189	-	-	-	KT	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_02432	3.05e-295	gltT	-	-	U	ko:K03309,ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
BIGEKKFO_02433	1.86e-123	-	-	-	S	ko:K08996	-	ko00000	Protein of unknown function (DUF1440)
BIGEKKFO_02434	1.2e-240	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
BIGEKKFO_02435	7.14e-157	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02436	2.76e-117	-	-	-	T	ko:K16923	-	ko00000,ko00002,ko02000	phosphorelay sensor kinase activity
BIGEKKFO_02437	4.9e-239	iunH3	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
BIGEKKFO_02438	2.92e-126	ywjB	-	-	H	-	-	-	RibD C-terminal domain
BIGEKKFO_02439	1.14e-257	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
BIGEKKFO_02440	9.01e-155	-	-	-	S	-	-	-	Membrane
BIGEKKFO_02441	2.11e-199	mleP3	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
BIGEKKFO_02442	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Fumarase C C-terminus
BIGEKKFO_02443	1.24e-260	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_02444	7.22e-163	-	3.8.1.2	-	S	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
BIGEKKFO_02445	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
BIGEKKFO_02446	1.16e-103	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
BIGEKKFO_02447	3.66e-132	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGEKKFO_02448	2.17e-222	-	-	-	S	-	-	-	Conserved hypothetical protein 698
BIGEKKFO_02449	1.19e-193	rlrG	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_02450	0.0	tagE5	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Poly(Glycerol-phosphate) alpha-glucosyltransferase
BIGEKKFO_02451	0.0	tagE6	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGEKKFO_02453	1.12e-86	-	-	-	M	-	-	-	LysM domain
BIGEKKFO_02454	3.92e-120	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Methyltransferase
BIGEKKFO_02456	4.23e-215	natA	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02457	6.47e-268	natB	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGEKKFO_02458	6.27e-166	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_02459	4.72e-72	cmd	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
BIGEKKFO_02460	4.77e-100	yphH	-	-	S	-	-	-	Cupin domain
BIGEKKFO_02461	3.65e-103	-	-	-	K	-	-	-	transcriptional regulator, MerR family
BIGEKKFO_02462	1.46e-299	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
BIGEKKFO_02463	0.0	ylbB	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
BIGEKKFO_02464	1.74e-156	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02466	2.93e-151	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIGEKKFO_02467	5.27e-140	thgA3	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
BIGEKKFO_02468	2.44e-149	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
BIGEKKFO_02469	1.52e-144	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
BIGEKKFO_02470	4.68e-109	-	-	-	-	-	-	-	-
BIGEKKFO_02471	4.4e-112	yvbK	-	-	K	-	-	-	GNAT family
BIGEKKFO_02472	2.8e-49	-	-	-	-	-	-	-	-
BIGEKKFO_02473	2.81e-64	-	-	-	-	-	-	-	-
BIGEKKFO_02474	5.46e-145	pgm8	-	-	G	-	-	-	Histidine phosphatase superfamily (branch 1)
BIGEKKFO_02475	1.49e-83	-	-	-	S	-	-	-	Domain of unknown function (DUF4440)
BIGEKKFO_02476	6.67e-204	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_02477	8.81e-135	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_02478	2.03e-248	adh2	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
BIGEKKFO_02479	6.82e-193	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGEKKFO_02481	2.1e-99	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
BIGEKKFO_02482	5.99e-124	maa	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
BIGEKKFO_02483	7.47e-164	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
BIGEKKFO_02484	5.69e-80	-	-	-	-	-	-	-	-
BIGEKKFO_02485	9.15e-132	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
BIGEKKFO_02486	3.31e-283	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
BIGEKKFO_02487	1.86e-132	-	-	-	M	-	-	-	Protein of unknown function (DUF3737)
BIGEKKFO_02488	5.17e-249	-	-	-	C	-	-	-	Aldo/keto reductase family
BIGEKKFO_02490	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_02491	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_02492	8.96e-317	-	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_02495	1.58e-230	yhgE	-	-	V	ko:K01421	-	ko00000	domain protein
BIGEKKFO_02496	1.59e-143	-	-	-	K	-	-	-	Transcriptional regulator (TetR family)
BIGEKKFO_02497	6.88e-71	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_02498	1.66e-199	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
BIGEKKFO_02499	3.69e-139	yokL3	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_02500	7.2e-125	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGEKKFO_02501	6.3e-169	-	-	-	M	-	-	-	Phosphotransferase enzyme family
BIGEKKFO_02502	7.82e-283	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGEKKFO_02503	0.0	ykpA	-	-	S	-	-	-	ABC transporter, ATP-binding protein
BIGEKKFO_02504	1.9e-189	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
BIGEKKFO_02505	0.0	-	-	-	S	-	-	-	Predicted membrane protein (DUF2207)
BIGEKKFO_02506	0.0	uvrA3	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC
BIGEKKFO_02507	4.4e-270	-	-	-	EGP	-	-	-	Major facilitator Superfamily
BIGEKKFO_02508	2.78e-222	ropB	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02509	1.18e-225	-	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
BIGEKKFO_02510	0.0	-	-	-	E	ko:K03294	-	ko00000	Amino acid permease
BIGEKKFO_02511	1.76e-298	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	Vacuole effluxer Atg22 like
BIGEKKFO_02512	0.0	npp	-	-	S	-	-	-	type I phosphodiesterase nucleotide pyrophosphatase
BIGEKKFO_02513	1.58e-203	-	-	-	I	-	-	-	alpha/beta hydrolase fold
BIGEKKFO_02514	5.86e-167	treR	-	-	K	ko:K03486	-	ko00000,ko03000	UTRA
BIGEKKFO_02515	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_02516	2e-52	-	-	-	S	-	-	-	Cytochrome B5
BIGEKKFO_02517	8.68e-118	pts21A	-	-	G	ko:K02755	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
BIGEKKFO_02518	2.05e-279	-	-	-	T	-	-	-	Diguanylate cyclase, GGDEF domain
BIGEKKFO_02519	2.82e-163	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
BIGEKKFO_02520	7.74e-135	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIGEKKFO_02521	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
BIGEKKFO_02522	1.56e-108	-	-	-	-	-	-	-	-
BIGEKKFO_02523	5.97e-96	def2	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
BIGEKKFO_02524	3.21e-243	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
BIGEKKFO_02525	1.26e-245	dus	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIGEKKFO_02526	3.7e-30	-	-	-	-	-	-	-	-
BIGEKKFO_02527	1.84e-134	-	-	-	-	-	-	-	-
BIGEKKFO_02528	5.12e-212	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_02529	4.34e-314	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
BIGEKKFO_02530	0.0	-	4.1.1.98	-	H	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
BIGEKKFO_02531	0.0	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
BIGEKKFO_02532	3.22e-181	-	-	-	S	-	-	-	zinc-ribbon domain
BIGEKKFO_02534	4.29e-50	-	-	-	-	-	-	-	-
BIGEKKFO_02535	1.48e-171	-	-	-	S	ko:K06889	-	ko00000	Alpha/beta hydrolase family
BIGEKKFO_02536	4.07e-232	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
BIGEKKFO_02537	0.0	-	-	-	I	-	-	-	acetylesterase activity
BIGEKKFO_02538	2.22e-301	-	-	-	M	-	-	-	Collagen binding domain
BIGEKKFO_02539	3.43e-206	yicL	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_02540	3.03e-166	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
BIGEKKFO_02541	3.53e-227	-	4.1.1.52	-	S	ko:K22213	-	ko00000,ko01000	Amidohydrolase
BIGEKKFO_02542	1.98e-142	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
BIGEKKFO_02543	8.76e-63	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGEKKFO_02544	1.85e-207	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
BIGEKKFO_02545	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
BIGEKKFO_02546	3.69e-124	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
BIGEKKFO_02547	8.08e-154	ydgI3	-	-	C	-	-	-	Nitroreductase family
BIGEKKFO_02548	0.0	nagE	2.7.1.193, 2.7.1.199, 2.7.1.208	-	G	ko:K02777,ko:K02802,ko:K02803,ko:K02804,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
BIGEKKFO_02549	9.16e-140	-	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_02550	4.78e-197	WQ51_06230	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGEKKFO_02551	1.71e-216	XK27_00670	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
BIGEKKFO_02552	4.95e-286	-	-	-	-	-	-	-	-
BIGEKKFO_02553	1.85e-19	-	-	-	-	-	-	-	-
BIGEKKFO_02554	8.13e-82	-	-	-	-	-	-	-	-
BIGEKKFO_02555	4.54e-241	-	-	-	S	-	-	-	Cell surface protein
BIGEKKFO_02556	1.27e-137	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02557	2.72e-124	acuB	-	-	S	ko:K04767	-	ko00000	Domain in cystathionine beta-synthase and other proteins.
BIGEKKFO_02558	2.78e-158	livF	-	-	E	ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_02559	1.28e-180	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid ATP-binding cassette transporter
BIGEKKFO_02560	1.88e-192	livM	-	-	E	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
BIGEKKFO_02561	1.96e-196	livH	-	-	U	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
BIGEKKFO_02562	4.23e-269	livJ	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Receptor family ligand binding region
BIGEKKFO_02564	1.15e-43	-	-	-	-	-	-	-	-
BIGEKKFO_02565	2.93e-169	zmp3	-	-	O	-	-	-	Zinc-dependent metalloprotease
BIGEKKFO_02566	2.88e-106	gtcA3	-	-	S	-	-	-	GtrA-like protein
BIGEKKFO_02567	4.08e-158	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02568	0.0	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
BIGEKKFO_02569	1.18e-94	usp2	-	-	T	-	-	-	Belongs to the universal stress protein A family
BIGEKKFO_02570	2.87e-61	-	-	-	-	-	-	-	-
BIGEKKFO_02571	1.81e-150	-	-	-	S	-	-	-	SNARE associated Golgi protein
BIGEKKFO_02572	8.58e-65	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
BIGEKKFO_02573	1.59e-123	-	-	-	P	-	-	-	Cadmium resistance transporter
BIGEKKFO_02574	0.0	yhcA	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02575	0.0	-	-	-	P	-	-	-	Concanavalin A-like lectin/glucanases superfamily
BIGEKKFO_02576	2.03e-84	-	-	-	-	-	-	-	-
BIGEKKFO_02577	1.93e-205	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
BIGEKKFO_02578	1.21e-73	-	-	-	-	-	-	-	-
BIGEKKFO_02579	5.06e-194	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_02580	3.91e-100	pts23A	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
BIGEKKFO_02581	2.14e-69	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_02582	0.0	pts23C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_02583	0.0	pbg6	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02584	4.51e-237	-	-	-	GM	-	-	-	Male sterility protein
BIGEKKFO_02585	2.1e-99	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_02586	4.61e-101	-	-	-	M	-	-	-	LysM domain
BIGEKKFO_02587	5.02e-129	-	-	-	M	-	-	-	Lysin motif
BIGEKKFO_02588	1.4e-138	-	-	-	S	-	-	-	SdpI/YhfL protein family
BIGEKKFO_02589	1.58e-72	nudA	-	-	S	-	-	-	ASCH
BIGEKKFO_02590	5.76e-212	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
BIGEKKFO_02591	3.57e-120	-	-	-	-	-	-	-	-
BIGEKKFO_02592	5.72e-157	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
BIGEKKFO_02593	6.14e-282	-	-	-	T	-	-	-	diguanylate cyclase
BIGEKKFO_02594	5.23e-97	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
BIGEKKFO_02595	0.0	umuC	-	-	L	ko:K03502	-	ko00000,ko03400	impB/mucB/samB family C-terminal domain
BIGEKKFO_02596	4.75e-214	-	-	-	K	-	-	-	Bacterial regulatory helix-turn-helix protein, lysR family
BIGEKKFO_02597	4.33e-95	-	-	-	-	-	-	-	-
BIGEKKFO_02598	6.54e-168	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_02599	5.37e-222	-	-	-	C	-	-	-	C4-dicarboxylate transmembrane transporter activity
BIGEKKFO_02600	2.51e-150	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_02601	1.17e-120	-	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
BIGEKKFO_02602	6.7e-102	yphH	-	-	S	-	-	-	Cupin domain
BIGEKKFO_02603	1.23e-76	-	-	-	I	-	-	-	sulfurtransferase activity
BIGEKKFO_02604	3.83e-178	gdh	1.1.1.47, 1.1.1.53	-	IQ	ko:K00034,ko:K00038	ko00030,ko00140,ko01100,ko01120,ko01200,map00030,map00140,map01100,map01120,map01200	ko00000,ko00001,ko01000	reductase
BIGEKKFO_02605	3.41e-151	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_02606	2.31e-277	-	-	-	-	-	-	-	-
BIGEKKFO_02607	0.0	-	-	-	V	ko:K06147,ko:K18892	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_02608	0.0	XK27_09600	-	-	V	ko:K06147,ko:K18891	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02609	1.3e-226	-	-	-	O	-	-	-	protein import
BIGEKKFO_02610	1.67e-292	amd	-	-	E	-	-	-	Peptidase family M20/M25/M40
BIGEKKFO_02611	2.84e-207	yhxD	-	-	IQ	-	-	-	KR domain
BIGEKKFO_02613	2.69e-90	-	-	-	-	-	-	-	-
BIGEKKFO_02614	8.63e-186	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02615	0.0	-	-	-	E	-	-	-	Amino Acid
BIGEKKFO_02616	5.83e-87	lysM	-	-	M	-	-	-	LysM domain
BIGEKKFO_02617	5.72e-284	dhaT	1.1.1.202	-	C	ko:K00086	ko00561,ko00640,map00561,map00640	ko00000,ko00001,ko01000	Dehydrogenase
BIGEKKFO_02618	3.77e-269	adhC	1.1.1.90	-	C	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Zn-dependent alcohol dehydrogenases, class III
BIGEKKFO_02619	0.0	copA	3.6.3.3, 3.6.3.4, 3.6.3.5, 3.6.3.54	-	P	ko:K01533,ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
BIGEKKFO_02620	2.04e-56	-	-	-	S	-	-	-	Cupredoxin-like domain
BIGEKKFO_02621	1.36e-84	-	-	-	S	-	-	-	Cupredoxin-like domain
BIGEKKFO_02622	0.0	aapA	-	-	M	-	-	-	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BIGEKKFO_02623	2.81e-181	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGEKKFO_02624	1.47e-51	-	-	-	S	ko:K07343	-	ko00000	TfoX C-terminal domain
BIGEKKFO_02625	3.05e-289	hpk9	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
BIGEKKFO_02626	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_02627	3.15e-98	-	-	-	-	-	-	-	-
BIGEKKFO_02628	2.07e-240	-	-	-	S	-	-	-	Cell surface protein
BIGEKKFO_02629	6.02e-137	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02630	1.88e-225	-	-	-	C	-	-	-	Alcohol dehydrogenase GroES-like domain
BIGEKKFO_02631	1.27e-90	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
BIGEKKFO_02632	3.33e-149	-	-	-	S	-	-	-	GyrI-like small molecule binding domain
BIGEKKFO_02633	1.59e-243	ynjC	-	-	S	-	-	-	Cell surface protein
BIGEKKFO_02634	7.74e-131	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02635	9.16e-290	-	-	-	NU	-	-	-	Mycoplasma protein of unknown function, DUF285
BIGEKKFO_02636	4.13e-157	-	-	-	-	-	-	-	-
BIGEKKFO_02637	4.31e-149	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
BIGEKKFO_02638	3.25e-81	ytcD	-	-	K	-	-	-	Transcriptional regulator, HxlR family
BIGEKKFO_02639	1.81e-272	-	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_02640	7.81e-148	-	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
BIGEKKFO_02641	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
BIGEKKFO_02642	1.09e-57	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
BIGEKKFO_02643	8.01e-174	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
BIGEKKFO_02644	1.77e-282	blpH	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
BIGEKKFO_02645	1.59e-130	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02646	5.35e-216	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02647	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
BIGEKKFO_02648	0.0	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
BIGEKKFO_02649	1.62e-62	-	-	-	S	-	-	-	Domain of unknown function (DUF1905)
BIGEKKFO_02650	1.27e-83	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGEKKFO_02651	3.27e-170	-	-	-	S	-	-	-	KR domain
BIGEKKFO_02652	4.08e-126	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02653	2.01e-243	-	1.1.1.219	-	GM	ko:K00091	-	ko00000,ko01000	Male sterility protein
BIGEKKFO_02654	1.09e-130	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
BIGEKKFO_02655	1.97e-229	ydhF	-	-	S	-	-	-	Aldo keto reductase
BIGEKKFO_02656	0.0	yfjF	-	-	U	-	-	-	Sugar (and other) transporter
BIGEKKFO_02657	7.57e-141	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02658	4.96e-219	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
BIGEKKFO_02659	6.37e-188	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGEKKFO_02660	1.81e-228	fhuB	-	-	U	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGEKKFO_02661	8.17e-220	fhuG	-	-	U	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGEKKFO_02662	3.74e-120	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02663	6.73e-211	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02664	1.43e-167	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGEKKFO_02665	3.78e-75	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
BIGEKKFO_02666	1.5e-193	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGEKKFO_02667	9.11e-84	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_02668	0.0	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
BIGEKKFO_02669	1.52e-227	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF916)
BIGEKKFO_02670	1.75e-112	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02671	1.05e-238	-	-	-	NU	-	-	-	Mycoplasma protein of unknown function, DUF285
BIGEKKFO_02672	4.84e-152	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02673	0.0	lepA2	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
BIGEKKFO_02674	0.0	nhaP4	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
BIGEKKFO_02675	4.54e-202	-	3.6.1.22	-	L	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	ko00000,ko00001,ko01000	NADH pyrophosphatase zinc ribbon domain
BIGEKKFO_02676	2.05e-203	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_02677	0.0	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
BIGEKKFO_02678	0.0	-	-	-	S	-	-	-	MucBP domain
BIGEKKFO_02680	8.08e-110	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
BIGEKKFO_02681	1.9e-148	-	-	-	K	ko:K03489	-	ko00000,ko03000	UTRA
BIGEKKFO_02682	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02683	0.0	celD	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_02684	2.09e-85	-	-	-	-	-	-	-	-
BIGEKKFO_02685	5.15e-16	-	-	-	-	-	-	-	-
BIGEKKFO_02686	5.61e-54	pcaC	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
BIGEKKFO_02687	6.86e-31	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGEKKFO_02688	2.08e-85	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
BIGEKKFO_02689	1.84e-279	-	-	-	S	-	-	-	Membrane
BIGEKKFO_02690	2.39e-102	-	-	-	K	-	-	-	transcriptional regulator
BIGEKKFO_02691	3.36e-186	-	-	-	S	-	-	-	Alpha/beta hydrolase family
BIGEKKFO_02692	2.74e-214	-	4.1.1.52	-	S	ko:K22213	-	ko00000,ko01000	Amidohydrolase
BIGEKKFO_02693	9.26e-68	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGEKKFO_02694	2.27e-191	-	-	-	C	-	-	-	Alcohol dehydrogenase GroES-like domain
BIGEKKFO_02695	5.49e-261	-	-	-	C	-	-	-	Belongs to the LDH2 MDH2 oxidoreductase family
BIGEKKFO_02697	3.64e-47	-	-	CBM50	NU	ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
BIGEKKFO_02698	1.23e-149	yciB	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
BIGEKKFO_02699	4.01e-142	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
BIGEKKFO_02700	7.85e-139	-	-	-	GM	-	-	-	NAD(P)H-binding
BIGEKKFO_02701	5.35e-102	-	-	-	GM	-	-	-	SnoaL-like domain
BIGEKKFO_02702	0.0	qacA	-	-	EGP	-	-	-	Fungal trichothecene efflux pump (TRI12)
BIGEKKFO_02703	2.95e-84	-	-	-	S	-	-	-	Domain of unknown function (DUF4440)
BIGEKKFO_02704	7.9e-136	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02705	9.59e-45	-	-	-	L	ko:K07483	-	ko00000	transposase activity
BIGEKKFO_02707	6.79e-53	-	-	-	-	-	-	-	-
BIGEKKFO_02708	5.06e-168	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIGEKKFO_02709	9.26e-233	ydbI	-	-	K	-	-	-	AI-2E family transporter
BIGEKKFO_02710	7.62e-270	xylR	-	-	GK	-	-	-	ROK family
BIGEKKFO_02711	9.37e-147	-	-	-	-	-	-	-	-
BIGEKKFO_02712	3.66e-295	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
BIGEKKFO_02713	4.04e-211	-	-	-	-	-	-	-	-
BIGEKKFO_02714	6.77e-259	pkn2	-	-	KLT	-	-	-	Protein tyrosine kinase
BIGEKKFO_02715	5.03e-37	-	-	-	S	-	-	-	Protein of unknown function (DUF4064)
BIGEKKFO_02716	2.47e-125	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
BIGEKKFO_02717	5.61e-98	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
BIGEKKFO_02718	1.02e-31	-	-	-	-	-	-	-	-
BIGEKKFO_02719	9.65e-141	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
BIGEKKFO_02720	5.93e-73	-	-	-	S	-	-	-	branched-chain amino acid
BIGEKKFO_02721	2.05e-167	-	-	-	E	-	-	-	branched-chain amino acid
BIGEKKFO_02722	1.66e-116	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
BIGEKKFO_02723	2.18e-304	dacA	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
BIGEKKFO_02724	5.61e-273	hpk31	-	-	T	-	-	-	Histidine kinase
BIGEKKFO_02725	1.14e-159	vanR	-	-	K	-	-	-	response regulator
BIGEKKFO_02726	2.4e-161	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
BIGEKKFO_02727	3.84e-207	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
BIGEKKFO_02728	3.49e-270	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
BIGEKKFO_02729	3.49e-160	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
BIGEKKFO_02730	6.6e-255	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
BIGEKKFO_02731	1.4e-40	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
BIGEKKFO_02732	6.14e-202	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
BIGEKKFO_02733	1.01e-175	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
BIGEKKFO_02734	7.39e-192	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
BIGEKKFO_02735	2.57e-168	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
BIGEKKFO_02736	3.35e-288	nupG	-	-	F	ko:K16323	-	ko00000,ko02000	Nucleoside
BIGEKKFO_02737	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
BIGEKKFO_02738	8.63e-188	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_02739	3.36e-216	-	-	-	K	-	-	-	LysR substrate binding domain
BIGEKKFO_02740	3.43e-301	-	-	-	EK	-	-	-	Aminotransferase, class I
BIGEKKFO_02741	1.11e-169	fliY	-	-	ET	ko:K02030,ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
BIGEKKFO_02742	7.06e-157	tcyB	-	-	E	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_02743	6.09e-176	-	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGEKKFO_02744	1.26e-161	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
BIGEKKFO_02745	8.83e-127	-	-	-	KT	-	-	-	response to antibiotic
BIGEKKFO_02746	1.72e-69	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_02747	1.73e-132	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
BIGEKKFO_02748	3.77e-199	-	-	-	S	-	-	-	Putative adhesin
BIGEKKFO_02749	0.0	pts26BCA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_02750	0.0	malL	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
BIGEKKFO_02751	8.69e-232	purR2	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
BIGEKKFO_02752	3.73e-263	-	-	-	S	-	-	-	DUF218 domain
BIGEKKFO_02753	2.44e-165	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	Uncharacterised protein family (UPF0014)
BIGEKKFO_02754	2.51e-152	ybbL	-	-	S	ko:K02068	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGEKKFO_02755	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIGEKKFO_02756	6.26e-101	-	-	-	-	-	-	-	-
BIGEKKFO_02757	8.05e-196	qorB	1.6.5.2	-	GM	ko:K19267	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NmrA-like family
BIGEKKFO_02758	4.13e-189	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
BIGEKKFO_02759	1.29e-115	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
BIGEKKFO_02760	0.0	mngB	3.2.1.170	GH38	G	ko:K15524	-	ko00000,ko01000	Glycosyl hydrolases family 38 N-terminal domain
BIGEKKFO_02761	6.69e-155	fptC	-	-	U	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase system, EIIC
BIGEKKFO_02762	2.52e-35	-	2.7.1.202	-	G	ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_02763	4.05e-22	-	-	-	G	ko:K11203	-	ko00000,ko00002,ko02000	PTS system, fructose subfamily
BIGEKKFO_02764	2.11e-104	manR	-	-	GKT	ko:K02538,ko:K03491	-	ko00000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_02765	4.08e-101	-	-	-	K	-	-	-	MerR family regulatory protein
BIGEKKFO_02766	7.54e-200	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02767	0.0	pts28ABC	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_02768	5.08e-164	nth2	-	-	L	ko:K07457	-	ko00000	Base excision DNA repair protein, HhH-GPD family
BIGEKKFO_02770	8.66e-130	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
BIGEKKFO_02771	3.43e-303	-	-	-	S	-	-	-	module of peptide synthetase
BIGEKKFO_02772	1.78e-139	-	-	-	-	-	-	-	-
BIGEKKFO_02773	1.55e-114	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
BIGEKKFO_02774	7.43e-77	-	-	-	S	-	-	-	Enterocin A Immunity
BIGEKKFO_02775	6.46e-49	-	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
BIGEKKFO_02776	1.54e-214	-	3.1.4.17, 3.1.4.53	-	S	ko:K01120,ko:K03651	ko00230,ko02025,map00230,map02025	ko00000,ko00001,ko01000	Calcineurin-like phosphoesterase
BIGEKKFO_02777	4.65e-134	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_02778	9.76e-83	lrgA	-	-	S	ko:K05338	ko02020,map02020	ko00000,ko00001,ko02000	LrgA family
BIGEKKFO_02779	2.88e-164	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	LrgB-like family
BIGEKKFO_02780	3.84e-186	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
BIGEKKFO_02781	1.03e-34	-	-	-	-	-	-	-	-
BIGEKKFO_02782	1.48e-152	yugP	-	-	S	ko:K06973	-	ko00000	Putative neutral zinc metallopeptidase
BIGEKKFO_02783	0.0	-	1.3.99.26, 1.3.99.28, 1.3.99.29, 1.3.99.31	-	Q	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	ko00000,ko00001,ko01000	Flavin containing amine oxidoreductase
BIGEKKFO_02784	8.52e-212	crtM	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Squalene/phytoene synthase
BIGEKKFO_02785	2.71e-234	-	-	-	D	ko:K06889	-	ko00000	Alpha beta
BIGEKKFO_02786	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_02787	4.27e-253	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
BIGEKKFO_02788	0.0	gshR3	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
BIGEKKFO_02789	2.49e-73	-	-	-	S	-	-	-	Enterocin A Immunity
BIGEKKFO_02790	7.41e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIGEKKFO_02791	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIGEKKFO_02792	7.21e-236	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
BIGEKKFO_02793	2.5e-188	ptp2	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
BIGEKKFO_02794	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIGEKKFO_02796	9.7e-109	-	-	-	-	-	-	-	-
BIGEKKFO_02797	0.0	yhdG	-	-	E	ko:K03294	-	ko00000	C-terminus of AA_permease
BIGEKKFO_02799	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
BIGEKKFO_02800	5.29e-212	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIGEKKFO_02801	1.54e-228	ydbI	-	-	K	-	-	-	AI-2E family transporter
BIGEKKFO_02802	6.1e-279	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
BIGEKKFO_02803	1.02e-78	qacC	-	-	P	ko:K03297,ko:K11741,ko:K11815	-	ko00000,ko00002,ko02000	Multidrug Resistance protein
BIGEKKFO_02804	1.97e-60	qacH	-	-	U	ko:K03297	-	ko00000,ko02000	Small Multidrug Resistance protein
BIGEKKFO_02805	2.94e-149	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
BIGEKKFO_02806	1.72e-71	-	-	-	K	ko:K21903	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGEKKFO_02807	7.52e-207	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
BIGEKKFO_02808	1.63e-133	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02810	2.77e-30	-	-	-	-	-	-	-	-
BIGEKKFO_02812	3.91e-124	tag2	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
BIGEKKFO_02813	4.79e-272	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	dihydropteroate synthase
BIGEKKFO_02814	2.01e-134	folQ	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Ham1 family
BIGEKKFO_02815	0.0	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
BIGEKKFO_02816	1.8e-134	folE	2.7.6.3, 3.5.4.16	-	F	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase 1
BIGEKKFO_02817	1.59e-121	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
BIGEKKFO_02818	9.61e-84	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIGEKKFO_02819	4.26e-109	cvpA	-	-	S	-	-	-	Colicin V production protein
BIGEKKFO_02820	5.61e-216	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
BIGEKKFO_02821	0.0	-	-	-	L	ko:K07487	-	ko00000	Transposase
BIGEKKFO_02822	4.41e-316	-	-	-	EGP	-	-	-	Major Facilitator
BIGEKKFO_02824	4.54e-54	-	-	-	-	-	-	-	-
BIGEKKFO_02825	1.35e-55	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
BIGEKKFO_02826	3.74e-125	-	-	-	V	-	-	-	VanZ like family
BIGEKKFO_02827	1.87e-249	-	-	-	V	-	-	-	Beta-lactamase
BIGEKKFO_02828	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
BIGEKKFO_02829	1.12e-206	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIGEKKFO_02830	8.93e-71	-	-	-	S	-	-	-	Pfam:DUF59
BIGEKKFO_02831	1.05e-223	ydhF	-	-	S	-	-	-	Aldo keto reductase
BIGEKKFO_02832	2.42e-127	-	-	-	FG	-	-	-	HIT domain
BIGEKKFO_02833	5.09e-51	-	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
BIGEKKFO_02834	4.29e-101	-	-	-	-	-	-	-	-
BIGEKKFO_02835	1.3e-157	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
BIGEKKFO_02836	0.0	-	-	-	U	ko:K03451	-	ko00000	Belongs to the BCCT transporter (TC 2.A.15) family
BIGEKKFO_02837	0.0	cadA	-	-	P	-	-	-	P-type ATPase
BIGEKKFO_02839	5.14e-46	-	-	-	S	-	-	-	YjbR
BIGEKKFO_02840	1.6e-85	-	-	-	S	-	-	-	YjbR
BIGEKKFO_02841	1.3e-282	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
BIGEKKFO_02842	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIGEKKFO_02843	7.12e-256	glmS2	-	-	M	-	-	-	SIS domain
BIGEKKFO_02844	1.56e-29	-	-	-	S	-	-	-	Belongs to the LOG family
BIGEKKFO_02845	0.0	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
BIGEKKFO_02846	0.0	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
BIGEKKFO_02847	2.65e-215	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
BIGEKKFO_02848	1.65e-112	pgpA	-	-	I	-	-	-	Phosphatidylglycerophosphatase A
BIGEKKFO_02849	1.36e-209	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02850	4.31e-86	-	-	-	K	ko:K22296	-	ko00000,ko03000	Winged helix DNA-binding domain
BIGEKKFO_02851	9.97e-94	spxA	-	-	P	ko:K16509	-	ko00000	ArsC family
BIGEKKFO_02852	3.46e-87	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
BIGEKKFO_02853	1.7e-70	-	-	-	-	-	-	-	-
BIGEKKFO_02854	4.98e-275	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific adenine glycosylase
BIGEKKFO_02855	2.11e-82	-	-	-	-	-	-	-	-
BIGEKKFO_02856	9.16e-111	-	-	-	-	-	-	-	-
BIGEKKFO_02857	4.58e-103	hsp3	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
BIGEKKFO_02858	4.59e-74	-	-	-	-	-	-	-	-
BIGEKKFO_02859	4.79e-21	-	-	-	-	-	-	-	-
BIGEKKFO_02860	3.57e-150	-	-	-	GM	-	-	-	NmrA-like family
BIGEKKFO_02861	2.52e-107	-	-	-	S	ko:K02348	-	ko00000	GNAT family
BIGEKKFO_02862	1.63e-203	-	-	-	EG	-	-	-	EamA-like transporter family
BIGEKKFO_02863	2.66e-155	-	-	-	S	-	-	-	membrane
BIGEKKFO_02864	1.47e-144	-	-	-	S	-	-	-	VIT family
BIGEKKFO_02865	4.38e-243	pva2	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
BIGEKKFO_02866	0.0	copB	3.6.3.3, 3.6.3.4, 3.6.3.5, 3.6.3.54	-	P	ko:K01533,ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
BIGEKKFO_02867	4.83e-98	copR	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Copper transport repressor CopY TcrY
BIGEKKFO_02868	4.26e-54	-	-	-	-	-	-	-	-
BIGEKKFO_02869	2.07e-97	-	-	-	S	-	-	-	COG NOG18757 non supervised orthologous group
BIGEKKFO_02870	8.8e-315	lmrB	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Belongs to the major facilitator superfamily
BIGEKKFO_02871	7.21e-35	-	-	-	-	-	-	-	-
BIGEKKFO_02872	4.39e-66	-	-	-	-	-	-	-	-
BIGEKKFO_02873	8.75e-85	-	-	-	S	-	-	-	Protein of unknown function (DUF1398)
BIGEKKFO_02874	0.0	-	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
BIGEKKFO_02875	7.22e-282	mdtG	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
BIGEKKFO_02876	5.99e-231	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
BIGEKKFO_02877	1.01e-99	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
BIGEKKFO_02878	5.44e-109	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
BIGEKKFO_02879	0.0	pacL3	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
BIGEKKFO_02880	0.0	yfkN	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
BIGEKKFO_02881	1.14e-204	ywkB	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
BIGEKKFO_02882	1.36e-209	yvgN	-	-	C	-	-	-	Aldo keto reductase
BIGEKKFO_02883	2.57e-171	-	-	-	S	-	-	-	Putative threonine/serine exporter
BIGEKKFO_02884	2.41e-101	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
BIGEKKFO_02885	1.05e-56	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
BIGEKKFO_02886	2.69e-190	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
BIGEKKFO_02887	5.94e-118	ymdB	-	-	S	-	-	-	Macro domain protein
BIGEKKFO_02888	6.47e-124	-	-	-	K	ko:K22041	-	ko00000,ko03000	transcriptional regulator
BIGEKKFO_02889	1.58e-66	-	-	-	-	-	-	-	-
BIGEKKFO_02890	2.41e-212	-	-	-	S	-	-	-	Protein of unknown function (DUF1002)
BIGEKKFO_02891	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_02892	1.36e-245	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF916)
BIGEKKFO_02893	5.48e-171	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02894	3.28e-176	yesN	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
BIGEKKFO_02895	5.33e-114	-	-	-	K	-	-	-	Winged helix DNA-binding domain
BIGEKKFO_02896	3.81e-150	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGEKKFO_02897	0.0	pckA	4.1.1.49	-	H	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Phosphoenolpyruvate carboxykinase
BIGEKKFO_02898	4.45e-38	-	-	-	-	-	-	-	-
BIGEKKFO_02899	0.0	gadB	4.1.1.15, 4.1.2.27	-	E	ko:K01580,ko:K01634	ko00250,ko00410,ko00430,ko00600,ko00650,ko01100,ko01110,ko01120,ko02024,ko04071,ko04727,ko04940,map00250,map00410,map00430,map00600,map00650,map01100,map01110,map01120,map02024,map04071,map04727,map04940	ko00000,ko00001,ko00002,ko01000	Belongs to the group II decarboxylase family
BIGEKKFO_02900	3e-98	-	-	-	M	-	-	-	PFAM NLP P60 protein
BIGEKKFO_02901	6.18e-71	-	-	-	-	-	-	-	-
BIGEKKFO_02902	9.96e-82	-	-	-	-	-	-	-	-
BIGEKKFO_02905	9.32e-84	-	-	-	V	-	-	-	VanZ like family
BIGEKKFO_02907	4.18e-16	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGEKKFO_02908	6.99e-136	-	-	-	-	-	-	-	-
BIGEKKFO_02909	3.95e-65	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2316)
BIGEKKFO_02910	4.61e-204	-	-	-	S	ko:K07045	-	ko00000	Amidohydrolase
BIGEKKFO_02911	6.51e-134	-	-	-	K	-	-	-	transcriptional regulator
BIGEKKFO_02912	1.24e-232	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Peroxidase
BIGEKKFO_02913	4.16e-175	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
BIGEKKFO_02914	6.13e-165	-	-	-	S	-	-	-	Gram-negative-bacterium-type cell wall biogenesis
BIGEKKFO_02915	3.52e-226	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
BIGEKKFO_02916	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	P-type ATPase
BIGEKKFO_02917	9.44e-183	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_02918	2.34e-72	trxA3	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Thioredoxin-like domain
BIGEKKFO_02919	4.82e-55	yrkD	-	-	S	-	-	-	Metal-sensitive transcriptional repressor
BIGEKKFO_02920	1.34e-26	-	-	-	-	-	-	-	-
BIGEKKFO_02921	4.1e-124	dpsB	-	-	P	-	-	-	Belongs to the Dps family
BIGEKKFO_02922	2.98e-44	copZ	-	-	P	-	-	-	Heavy-metal-associated domain
BIGEKKFO_02923	1.5e-151	rcfA	-	-	K	ko:K21562	-	ko00000,ko03000	Transcriptional regulator, Crp Fnr family
BIGEKKFO_02924	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
BIGEKKFO_02925	2.49e-105	yoaA	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIGEKKFO_02926	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
BIGEKKFO_02927	0.0	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
BIGEKKFO_02928	1.83e-235	-	-	-	S	-	-	-	Cell surface protein
BIGEKKFO_02929	8.67e-160	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02930	4.23e-129	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
BIGEKKFO_02931	7.83e-60	-	-	-	-	-	-	-	-
BIGEKKFO_02932	1.72e-135	yezE	-	-	K	ko:K16137	-	ko00000,ko03000	Bacterial regulatory proteins, tetR family
BIGEKKFO_02933	1.03e-65	-	-	-	-	-	-	-	-
BIGEKKFO_02934	9.34e-317	-	-	-	S	-	-	-	Putative metallopeptidase domain
BIGEKKFO_02935	4.03e-283	-	-	-	S	-	-	-	associated with various cellular activities
BIGEKKFO_02936	1.95e-140	aqpZ	-	-	U	ko:K06188	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGEKKFO_02937	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	ABC1 family
BIGEKKFO_02938	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
BIGEKKFO_02939	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
BIGEKKFO_02940	0.0	lacA	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	-beta-galactosidase
BIGEKKFO_02941	6.72e-242	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_02942	0.0	-	3.2.1.40	-	G	ko:K05989	-	ko00000,ko01000	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
BIGEKKFO_02943	2.04e-293	-	-	-	P	ko:K06610	-	ko00000,ko02000	Sugar (and other) transporter
BIGEKKFO_02944	0.0	ram2	3.2.1.40	-	G	ko:K05989	-	ko00000,ko01000	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
BIGEKKFO_02945	5.06e-298	-	-	-	P	ko:K06610	-	ko00000,ko02000	Major Facilitator Superfamily
BIGEKKFO_02946	7.48e-235	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGEKKFO_02947	3.9e-143	fic	-	-	D	ko:K04095	-	ko00000,ko03036	Fic/DOC family
BIGEKKFO_02948	3.4e-100	-	-	-	K	ko:K07726	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
BIGEKKFO_02949	1.19e-234	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_02950	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
BIGEKKFO_02951	1.26e-245	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIGEKKFO_02952	1.65e-286	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIGEKKFO_02953	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
BIGEKKFO_02954	1.64e-238	lacM	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase
BIGEKKFO_02955	0.0	melA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
BIGEKKFO_02956	0.0	lacP	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
BIGEKKFO_02957	4.27e-253	galM3	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
BIGEKKFO_02958	3.69e-232	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_02959	8.93e-249	tas3	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo keto reductase family protein
BIGEKKFO_02960	2.02e-85	-	-	-	S	-	-	-	pyridoxamine 5-phosphate
BIGEKKFO_02961	0.0	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
BIGEKKFO_02962	1.83e-230	apbE3	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
BIGEKKFO_02963	1.61e-175	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
BIGEKKFO_02964	7.89e-213	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIGEKKFO_02965	4.62e-224	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
BIGEKKFO_02966	1.4e-282	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_02967	1.2e-207	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIGEKKFO_02968	9.89e-207	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIGEKKFO_02969	1.64e-202	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
BIGEKKFO_02970	5.56e-212	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGEKKFO_02971	5.77e-214	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
BIGEKKFO_02972	1.12e-262	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGEKKFO_02973	2.09e-83	-	-	-	-	-	-	-	-
BIGEKKFO_02974	2.63e-200	estA	-	-	S	-	-	-	Putative esterase
BIGEKKFO_02975	5.44e-174	-	-	-	K	-	-	-	UTRA domain
BIGEKKFO_02976	1.87e-316	pts29C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGEKKFO_02977	5.07e-211	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIGEKKFO_02978	3.71e-206	-	-	-	G	-	-	-	BadF/BadG/BcrA/BcrD ATPase family
BIGEKKFO_02979	7.57e-268	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
BIGEKKFO_02980	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02981	0.0	bglP	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_02982	1.51e-199	bglG4	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
BIGEKKFO_02983	0.0	-	-	-	G	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_02984	4.72e-286	malY	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
BIGEKKFO_02985	0.0	pts31BC	-	-	G	ko:K11202,ko:K11203	-	ko00000,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_02986	2.02e-97	-	-	-	G	ko:K11201	-	ko00000,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_02987	5.18e-104	-	2.7.1.208	-	G	ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
BIGEKKFO_02988	4.82e-192	yleF	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGEKKFO_02989	0.0	pts32BC	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_02990	8.71e-202	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIGEKKFO_02991	5.63e-253	-	4.2.1.126	-	S	ko:K07106,ko:K09963	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Bacterial protein of unknown function (DUF871)
BIGEKKFO_02992	0.0	pbg9	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02993	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_02994	0.0	pts33BCA	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGEKKFO_02995	1.3e-203	bglG5	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
BIGEKKFO_02996	0.0	treP	2.4.1.64	GH65	G	ko:K05342	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
BIGEKKFO_02997	2.66e-222	cytR	-	-	K	ko:K02529,ko:K03604	-	ko00000,ko03000	Transcriptional regulator, LacI family
BIGEKKFO_02998	0.0	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
BIGEKKFO_02999	0.0	agl	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
BIGEKKFO_03001	2.83e-237	cbh	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
BIGEKKFO_03002	1.49e-185	yxeH	-	-	S	-	-	-	hydrolase
BIGEKKFO_03003	0.0	tkt	2.2.1.1	-	H	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIGEKKFO_03004	7.45e-150	tal	2.2.1.2	-	F	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIGEKKFO_03005	2.47e-307	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
BIGEKKFO_03006	7.29e-61	ulaB	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase system galactitol-specific IIB component
BIGEKKFO_03007	1.58e-101	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_03008	0.0	-	-	-	G	ko:K03483	-	ko00000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_03009	4.53e-146	gph3	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
BIGEKKFO_03010	5.26e-247	-	1.1.1.14	-	C	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Zinc-binding dehydrogenase
BIGEKKFO_03011	8.37e-296	gatC	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
BIGEKKFO_03012	4.94e-59	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGEKKFO_03013	7.73e-104	-	2.7.1.200, 2.7.1.204	-	G	ko:K02773,ko:K20112	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_03014	3.05e-161	-	-	-	K	ko:K02444	-	ko00000,ko03000	DeoR C terminal sensor domain
BIGEKKFO_03015	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
BIGEKKFO_03016	1.73e-93	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
BIGEKKFO_03017	6.83e-133	maa	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
BIGEKKFO_03018	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
BIGEKKFO_03019	8.71e-175	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
BIGEKKFO_03020	0.0	araB	2.7.1.16	-	G	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	carbohydrate kinase FGGY
BIGEKKFO_03021	0.0	araP	-	-	U	-	-	-	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
BIGEKKFO_03022	3.44e-262	araR	-	-	K	ko:K02103	-	ko00000,ko03000	Transcriptional regulator
BIGEKKFO_03023	1.23e-158	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIGEKKFO_03024	5.6e-292	-	-	-	S	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
BIGEKKFO_03025	2.43e-91	-	-	-	S	-	-	-	Pyrimidine dimer DNA glycosylase
BIGEKKFO_03026	2.1e-116	-	-	-	T	-	-	-	ECF transporter, substrate-specific component
BIGEKKFO_03027	1.06e-16	-	-	-	-	-	-	-	-
BIGEKKFO_03028	1.96e-21	ytgB	-	-	S	-	-	-	Transglycosylase associated protein
BIGEKKFO_03029	0.0	katA	1.11.1.6	-	C	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	Belongs to the catalase family
BIGEKKFO_03030	1.32e-101	nrp	-	-	K	ko:K16509	-	ko00000	ArsC family
BIGEKKFO_03031	3.67e-174	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
BIGEKKFO_03032	7.01e-286	blpH	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
BIGEKKFO_03033	3.82e-24	-	-	-	-	-	-	-	-
BIGEKKFO_03034	2.91e-125	-	-	-	KOT	ko:K07813	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01002	May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor
BIGEKKFO_03035	1.11e-215	clpL	-	-	O	ko:K04086	-	ko00000,ko03110	C-terminal, D2-small domain, of ClpB protein
BIGEKKFO_03036	1.91e-254	clpL	-	-	O	ko:K04086	-	ko00000,ko03110	C-terminal, D2-small domain, of ClpB protein
BIGEKKFO_03038	8.03e-256	lctO	1.13.12.4	-	C	ko:K00467,ko:K10530	ko00620,map00620	ko00000,ko00001,ko01000	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
BIGEKKFO_03039	0.0	pox4	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_03040	5.03e-95	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_03041	0.0	spxB	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
BIGEKKFO_03042	4.04e-94	yueI	-	-	S	-	-	-	Protein of unknown function (DUF1694)
BIGEKKFO_03043	1.45e-162	-	-	-	S	-	-	-	Membrane
BIGEKKFO_03044	5.34e-210	rhaD	4.1.2.19	-	H	ko:K01629	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
BIGEKKFO_03045	0.0	rhaA	2.7.1.5, 5.3.1.14	-	G	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	L-rhamnose isomerase (RhaA)
BIGEKKFO_03046	4.22e-74	rhaM	5.1.3.32	-	G	ko:K03534	-	ko00000,ko01000	Involved in the anomeric conversion of L-rhamnose
BIGEKKFO_03047	0.0	rhaB	2.7.1.5	-	F	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
BIGEKKFO_03048	4.04e-315	iolF	-	-	P	ko:K06610	-	ko00000,ko02000	Sugar (and other) transporter
BIGEKKFO_03049	1.44e-230	rhaR	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGEKKFO_03050	3.67e-180	-	-	-	K	-	-	-	DeoR C terminal sensor domain
BIGEKKFO_03051	3.71e-105	pts36A	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGEKKFO_03052	0.0	bgl	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGEKKFO_03053	1.4e-205	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
BIGEKKFO_03054	0.0	-	2.3.1.204, 3.2.1.170, 3.2.1.24	GH38	G	ko:K01191,ko:K15524,ko:K16869	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Glycosyl hydrolases family 38 N-terminal domain
BIGEKKFO_03055	0.0	-	-	-	S	ko:K09704	-	ko00000	Metal-independent alpha-mannosidase (GH125)
BIGEKKFO_03056	3.24e-249	-	-	-	K	-	-	-	Transcriptional regulator
BIGEKKFO_03057	0.0	ypdD	-	-	G	-	-	-	Glycosyl hydrolase family 92
BIGEKKFO_03058	1.09e-275	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGEKKFO_03059	3.76e-212	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
BIGEKKFO_03060	0.0	-	-	-	K	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
BIGEKKFO_03061	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGEKKFO_03062	1.71e-139	ypcB	-	-	S	-	-	-	integral membrane protein
BIGEKKFO_03063	0.0	dexB	3.2.1.70	-	G	ko:K01215	-	ko00000,ko01000	Alpha amylase, catalytic domain protein
BIGEKKFO_03064	0.0	ypcG	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Domain of unknown function (DUF3502)
BIGEKKFO_03065	6.47e-213	lplC	-	-	U	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_03066	1.29e-231	ypdA	-	-	U	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGEKKFO_03067	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycosyl hydrolase family 20, catalytic domain
BIGEKKFO_03068	1.92e-199	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGEKKFO_03069	0.0	mdlA2	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
BIGEKKFO_03070	0.0	yknV	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGEKKFO_03071	1.22e-246	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
BIGEKKFO_03072	1.91e-201	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
BIGEKKFO_03073	6.96e-83	pts38A	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
BIGEKKFO_03074	2.5e-234	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Sorbitol phosphotransferase enzyme II N-terminus
BIGEKKFO_03075	1.23e-129	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
BIGEKKFO_03076	3.33e-113	srlM1	-	-	K	-	-	-	Glucitol operon activator protein (GutM)
BIGEKKFO_03077	0.0	srlM	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
BIGEKKFO_03078	2.21e-185	srlD2	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	NAD dependent epimerase/dehydratase family
BIGEKKFO_03079	1.2e-207	rbsU	-	-	U	ko:K06216	-	ko00000,ko02000	ribose uptake protein RbsU
BIGEKKFO_03080	4.99e-88	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
BIGEKKFO_03081	7.82e-210	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIGEKKFO_03082	4.04e-241	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGEKKFO_03083	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
BIGEKKFO_03084	2.51e-103	-	-	-	T	-	-	-	Universal stress protein family
BIGEKKFO_03085	1.75e-128	padR	-	-	K	-	-	-	Virulence activator alpha C-term
BIGEKKFO_03086	2.71e-135	padC	-	-	Q	ko:K13727	-	ko00000,ko01000	Phenolic acid decarboxylase
BIGEKKFO_03087	1.13e-182	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
BIGEKKFO_03088	8.58e-220	-	-	-	L	ko:K07482	-	ko00000	Transposase and inactivated derivatives, IS30 family
BIGEKKFO_03089	2.3e-112	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGEKKFO_03090	4.02e-203	degV1	-	-	S	-	-	-	DegV family
BIGEKKFO_03091	9.67e-79	-	-	-	K	-	-	-	Bacteriophage CI repressor helix-turn-helix domain
BIGEKKFO_03092	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
BIGEKKFO_03094	1.12e-140	sip3	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
BIGEKKFO_03095	0.0	-	-	-	-	-	-	-	-
BIGEKKFO_03096	1.29e-210	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF916)
BIGEKKFO_03097	1.31e-143	-	-	-	S	-	-	-	Cell surface protein
BIGEKKFO_03098	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
BIGEKKFO_03099	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIGEKKFO_03100	1.59e-171	jag	-	-	S	ko:K06346	-	ko00000	R3H domain protein
BIGEKKFO_03101	2.26e-306	-	-	-	Q	-	-	-	Imidazolonepropionase and related amidohydrolases
BIGEKKFO_03102	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
BIGEKKFO_03103	1.55e-158	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
BIGEKKFO_03104	3.74e-75	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme