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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
APPLDMEG_00001	0.0	-	3.5.1.28	-	S	ko:K01448,ko:K02395,ko:K21471	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036	dextransucrase activity
APPLDMEG_00002	0.0	lpdA	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
APPLDMEG_00003	1.43e-273	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APPLDMEG_00004	4.65e-231	acoB	1.2.4.1	-	C	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
APPLDMEG_00005	5.91e-234	acoA	1.2.4.1	-	C	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
APPLDMEG_00006	7.53e-257	hpk9	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_00007	1.59e-287	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_00008	0.0	-	-	-	S	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_00009	1.2e-299	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
APPLDMEG_00010	4.01e-154	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APPLDMEG_00011	4.78e-271	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APPLDMEG_00012	4.82e-310	dacA1	3.4.16.4	-	M	ko:K01286	-	ko00000,ko01000	Belongs to the peptidase S11 family
APPLDMEG_00013	4.57e-229	dacA1	3.4.16.4	-	M	ko:K01286	-	ko00000,ko01000	Belongs to the peptidase S11 family
APPLDMEG_00014	5.43e-194	-	-	-	S	-	-	-	Phospholipase, patatin family
APPLDMEG_00015	5.37e-131	-	-	-	E	-	-	-	Lysophospholipase L1 and related esterases
APPLDMEG_00016	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	unusual protein kinase
APPLDMEG_00017	3.9e-51	-	-	-	S	-	-	-	granule-associated protein
APPLDMEG_00018	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
APPLDMEG_00019	5.36e-251	XK27_12525	-	-	S	-	-	-	hmm pf01594
APPLDMEG_00020	8.03e-141	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
APPLDMEG_00021	7.51e-138	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
APPLDMEG_00022	9.54e-140	XK27_06100	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
APPLDMEG_00023	1.08e-181	supH	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
APPLDMEG_00025	4.31e-236	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
APPLDMEG_00026	8.81e-219	wefC	-	-	M	-	-	-	Stealth protein CR2, conserved region 2
APPLDMEG_00027	2.47e-275	glf	5.4.99.9	-	M	ko:K01854	ko00052,ko00520,map00052,map00520	ko00000,ko00001,ko01000	UDP-galactopyranose mutase
APPLDMEG_00028	5.91e-202	-	-	-	S	-	-	-	Acyltransferase family
APPLDMEG_00029	6.71e-315	wzx	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
APPLDMEG_00030	1.37e-219	-	-	-	-	-	-	-	-
APPLDMEG_00031	4.36e-195	-	-	-	M	-	-	-	Glycosyltransferase like family 2
APPLDMEG_00032	7.38e-208	-	-	-	M	-	-	-	Glycosyltransferase, group 2 family protein
APPLDMEG_00033	3.58e-157	-	-	-	M	-	-	-	Domain of unknown function (DUF1919)
APPLDMEG_00034	6.29e-272	-	-	-	M	-	-	-	Glycosyltransferase, group 1 family protein
APPLDMEG_00035	5.72e-284	rgpAc	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	group 1 family protein
APPLDMEG_00036	0.0	cpsE	-	-	M	-	-	-	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
APPLDMEG_00037	1.29e-153	cpsD	-	-	D	-	-	-	COG0489 ATPases involved in chromosome partitioning
APPLDMEG_00038	8.78e-144	capA	-	-	M	-	-	-	biosynthesis protein
APPLDMEG_00039	7.12e-170	cpsB	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	Capsular polysaccharide biosynthesis protein
APPLDMEG_00040	0.0	cps4A	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
APPLDMEG_00041	1.28e-164	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	purine nucleoside phosphorylase
APPLDMEG_00042	9.05e-170	gat	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	glutamine amidotransferase
APPLDMEG_00043	9.35e-219	-	-	-	P	-	-	-	Chloride transporter, ClC family
APPLDMEG_00044	8.38e-191	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APPLDMEG_00045	2.55e-112	-	-	-	S	-	-	-	Protein of unknown function (DUF1697)
APPLDMEG_00046	8.67e-297	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APPLDMEG_00047	2.79e-154	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APPLDMEG_00048	0.0	-	-	-	V	ko:K13732	ko05100,map05100	ko00000,ko00001	Glucan-binding protein C
APPLDMEG_00049	0.0	-	-	-	V	-	-	-	Glucan-binding protein C
APPLDMEG_00050	5.79e-138	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
APPLDMEG_00051	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Dipeptidase
APPLDMEG_00052	1.38e-37	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
APPLDMEG_00053	3.18e-118	yybC	-	-	-	-	-	-	-
APPLDMEG_00054	1.25e-99	XK27_03610	-	-	K	-	-	-	Gnat family
APPLDMEG_00055	1.82e-73	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APPLDMEG_00056	2.36e-38	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
APPLDMEG_00057	1.1e-115	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APPLDMEG_00058	4.13e-156	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
APPLDMEG_00059	3.71e-29	-	-	-	M	-	-	-	LysM domain
APPLDMEG_00060	2.86e-113	ebsA	-	-	S	-	-	-	Family of unknown function (DUF5322)
APPLDMEG_00061	7.05e-289	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
APPLDMEG_00062	2.02e-165	lytC_1	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-acetylmuramoyl-L-alanine amidase
APPLDMEG_00063	3.54e-105	hmpT	-	-	S	-	-	-	cog cog4720
APPLDMEG_00064	5e-175	thiD	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	phosphomethylpyrimidine kinase
APPLDMEG_00065	6.12e-178	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
APPLDMEG_00066	6.04e-252	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
APPLDMEG_00068	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
APPLDMEG_00069	2.44e-105	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APPLDMEG_00070	5.47e-236	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
APPLDMEG_00071	6.47e-128	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Muramidase (Flagellum-specific)
APPLDMEG_00072	2.03e-180	yodJ	3.4.16.4, 3.4.17.14	-	M	ko:K01286,ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
APPLDMEG_00073	1.9e-165	gpmB	-	-	G	ko:K15640	-	ko00000	Phosphoglycerate mutase
APPLDMEG_00074	1.73e-306	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
APPLDMEG_00075	4.16e-51	XK27_08630	-	-	T	ko:K07166	-	ko00000	UPF0237 protein
APPLDMEG_00076	7.37e-296	capA	-	-	M	ko:K07282	-	ko00000	Bacterial capsule synthesis protein
APPLDMEG_00077	2.05e-191	srtB	-	-	S	-	-	-	Sortase family
APPLDMEG_00079	3.02e-40	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
APPLDMEG_00081	1.73e-19	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
APPLDMEG_00083	3.42e-66	frnE	5.3.4.1	-	Q	ko:K01829	-	ko00000,ko01000	DSBA-like thioredoxin domain
APPLDMEG_00085	3.77e-157	trxB1	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APPLDMEG_00086	2.4e-21	trxB1	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APPLDMEG_00087	1.14e-62	-	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
APPLDMEG_00089	9.66e-128	-	-	-	K	-	-	-	Rhodanese Homology Domain
APPLDMEG_00090	1.31e-34	int2	-	-	L	-	-	-	Belongs to the 'phage' integrase family
APPLDMEG_00091	2.12e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
APPLDMEG_00092	7.02e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APPLDMEG_00093	1.21e-40	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional
APPLDMEG_00095	2.29e-192	yitS	-	-	S	-	-	-	DegV family
APPLDMEG_00096	5.73e-120	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
APPLDMEG_00097	2.9e-171	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPLDMEG_00099	4.76e-87	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APPLDMEG_00100	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
APPLDMEG_00101	4.02e-144	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	serine acetyltransferase
APPLDMEG_00102	3.26e-177	-	-	-	S	-	-	-	SseB protein N-terminal domain
APPLDMEG_00103	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
APPLDMEG_00104	9.91e-288	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
APPLDMEG_00105	1.86e-293	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
APPLDMEG_00106	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
APPLDMEG_00107	5.72e-99	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
APPLDMEG_00108	3.41e-107	-	-	-	S	-	-	-	Putative small multi-drug export protein
APPLDMEG_00109	1.23e-233	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APPLDMEG_00110	2.48e-176	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
APPLDMEG_00111	4.96e-136	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	alkyl hydroperoxide reductase
APPLDMEG_00112	0.0	ahpF	-	-	O	ko:K03387	-	ko00000,ko01000	alkyl hydroperoxide reductase
APPLDMEG_00114	8.98e-122	XK27_03570	-	-	S	ko:K19784	-	ko00000	reductase
APPLDMEG_00115	1.89e-95	-	-	-	K	-	-	-	Transcriptional regulator, marr family
APPLDMEG_00116	1.4e-48	XK27_02060	-	-	S	-	-	-	Transglycosylase associated protein
APPLDMEG_00117	1.25e-301	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
APPLDMEG_00118	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APPLDMEG_00129	0.0	-	-	-	M	-	-	-	domain protein
APPLDMEG_00130	0.0	-	-	-	M	ko:K08643	-	ko00000,ko01000,ko01002	signal peptide protein, YSIRK family
APPLDMEG_00131	0.0	-	-	-	GM	-	-	-	domain, Protein
APPLDMEG_00132	9.05e-278	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
APPLDMEG_00133	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	ATPase involved in DNA repair
APPLDMEG_00134	0.0	-	-	-	M	-	-	-	family 8
APPLDMEG_00135	2.85e-268	secY2	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the accessory SecA2 SecY2 system specifically required for export of
APPLDMEG_00136	0.0	asp1	-	-	S	ko:K12268	-	ko00000,ko02044	Accessory Sec system protein Asp1
APPLDMEG_00137	0.0	asp2	-	-	S	ko:K12269	-	ko00000,ko02044	Accessory Sec system protein Asp2
APPLDMEG_00138	2.86e-102	asp3	-	-	S	ko:K12270	-	ko00000,ko02044	Accessory Sec system protein Asp3
APPLDMEG_00139	0.0	secA2	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APPLDMEG_00140	0.0	gtf1	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APPLDMEG_00141	4.63e-309	gtf2	-	-	M	-	-	-	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APPLDMEG_00142	3.27e-24	-	-	-	S	-	-	-	Accessory secretory protein Sec Asp4
APPLDMEG_00143	3.67e-23	-	-	-	S	-	-	-	Accessory secretory protein Sec, Asp5
APPLDMEG_00144	2.83e-237	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
APPLDMEG_00145	0.0	sraP	-	-	UW	ko:K18491,ko:K21449	ko04550,map04550	ko00000,ko00001,ko02000,ko03000	Hep Hag repeat protein
APPLDMEG_00146	2.63e-93	sraP	-	-	UW	ko:K18491,ko:K21449	ko04550,map04550	ko00000,ko00001,ko02000,ko03000	Hep Hag repeat protein
APPLDMEG_00147	1.18e-153	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	o-acetylhomoserine
APPLDMEG_00148	1.49e-175	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
APPLDMEG_00149	4.08e-112	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APPLDMEG_00150	1.91e-142	hsdS2	-	-	V	-	-	-	Type I restriction modification DNA specificity domain
APPLDMEG_00151	5.05e-47	M1-755	-	-	P	ko:K09155	-	ko00000	Hemerythrin HHE cation binding domain protein
APPLDMEG_00152	4.42e-306	XK27_04775	-	-	S	ko:K09155	-	ko00000	hemerythrin HHE cation binding domain
APPLDMEG_00153	3.03e-188	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APPLDMEG_00154	9.99e-216	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
APPLDMEG_00155	2.07e-92	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
APPLDMEG_00156	1.7e-59	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
APPLDMEG_00157	7.38e-181	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
APPLDMEG_00158	4.64e-311	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
APPLDMEG_00159	3.28e-199	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	phosphate
APPLDMEG_00160	6.3e-199	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
APPLDMEG_00161	1.24e-200	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	phosphate transport system permease
APPLDMEG_00162	1.02e-190	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APPLDMEG_00163	2.49e-179	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
APPLDMEG_00164	1.56e-147	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
APPLDMEG_00165	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
APPLDMEG_00166	3.44e-244	xerS	-	-	D	ko:K04763	-	ko00000,ko03036	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division
APPLDMEG_00167	2.07e-237	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
APPLDMEG_00169	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APPLDMEG_00170	0.0	malQ	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
APPLDMEG_00171	3.73e-221	malR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
APPLDMEG_00172	7.11e-293	malX	-	-	G	ko:K15770	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
APPLDMEG_00173	2.76e-316	malF	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00174	5.24e-194	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00175	4.77e-270	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
APPLDMEG_00176	6.58e-32	tatA	-	-	U	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	protein secretion
APPLDMEG_00177	1.26e-158	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APPLDMEG_00178	0.0	ywbL	-	-	P	ko:K07243	-	ko00000,ko02000	COG0672 High-affinity Fe2 Pb2 permease
APPLDMEG_00179	9.68e-293	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	peroxidase
APPLDMEG_00180	2.75e-191	ycdO	-	-	P	ko:K07224	-	ko00000,ko02000	periplasmic lipoprotein involved in iron transport
APPLDMEG_00181	0.0	pulA2	3.2.1.1, 3.2.1.41	CBM48,GH13	G	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
APPLDMEG_00182	3.6e-160	lytC_1	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-acetylmuramoyl-L-alanine amidase
APPLDMEG_00183	8.92e-87	spxA_2	1.20.4.1	-	P	ko:K00537,ko:K16509	-	ko00000,ko01000	Belongs to the ArsC family
APPLDMEG_00184	4.16e-260	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APPLDMEG_00185	3.08e-286	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
APPLDMEG_00186	3.08e-134	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	3-methyladenine DNA glycosylase
APPLDMEG_00187	1.78e-133	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
APPLDMEG_00189	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APPLDMEG_00191	3.1e-91	-	-	-	K	-	-	-	LytTr DNA-binding domain
APPLDMEG_00192	1.46e-101	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
APPLDMEG_00193	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APPLDMEG_00194	7.11e-71	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
APPLDMEG_00195	4.46e-89	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
APPLDMEG_00196	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APPLDMEG_00197	1.75e-313	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APPLDMEG_00198	6.01e-45	-	-	-	-	-	-	-	-
APPLDMEG_00199	1.96e-224	-	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Ketopantoate reductase
APPLDMEG_00200	3.84e-257	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APPLDMEG_00201	6.49e-104	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APPLDMEG_00202	3.73e-302	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
APPLDMEG_00203	2.61e-199	-	-	-	S	-	-	-	CHAP domain
APPLDMEG_00204	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
APPLDMEG_00205	1.89e-129	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APPLDMEG_00206	6.46e-242	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
APPLDMEG_00207	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APPLDMEG_00208	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APPLDMEG_00209	1.75e-166	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
APPLDMEG_00210	2.97e-41	acpP_1	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APPLDMEG_00211	1.19e-234	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
APPLDMEG_00212	1.74e-177	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
APPLDMEG_00213	1.23e-274	araT	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
APPLDMEG_00214	5.55e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APPLDMEG_00215	1.75e-145	pcsB	-	-	S	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain
APPLDMEG_00216	1.18e-109	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
APPLDMEG_00217	3.94e-156	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
APPLDMEG_00231	5.31e-22	-	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
APPLDMEG_00232	1.49e-196	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
APPLDMEG_00233	2.03e-35	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
APPLDMEG_00234	3.26e-293	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APPLDMEG_00236	2.02e-248	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
APPLDMEG_00237	2.51e-166	-	-	-	G	-	-	-	Domain of unknown function (DUF4832)
APPLDMEG_00238	1.31e-107	-	-	-	S	-	-	-	membrane
APPLDMEG_00239	1.21e-122	-	-	-	P	-	-	-	VTC domain
APPLDMEG_00240	8.44e-280	-	-	-	M	ko:K06330	-	ko00000	CotH kinase protein
APPLDMEG_00241	3.13e-242	-	-	-	M	ko:K21012	ko02025,map02025	ko00000,ko00001	Putative exopolysaccharide Exporter (EPS-E)
APPLDMEG_00242	0.0	-	2.4.1.52	GT4	M	ko:K00712,ko:K21011	ko02025,map02025	ko00000,ko00001,ko01000,ko01003	Domain of unknown function (DUF3492)
APPLDMEG_00243	0.0	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2194)
APPLDMEG_00244	1.19e-187	-	-	-	-	-	-	-	-
APPLDMEG_00245	0.0	-	5.1.3.2	-	GM	ko:K01784,ko:K21009	ko00052,ko00520,ko01100,ko02025,map00052,map00520,map01100,map02025	ko00000,ko00001,ko00002,ko01000	Psort location CytoplasmicMembrane, score
APPLDMEG_00246	2.98e-269	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APPLDMEG_00247	8.9e-219	birA	6.3.4.15	-	HK	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
APPLDMEG_00248	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APPLDMEG_00249	2.08e-112	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
APPLDMEG_00250	6.36e-203	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APPLDMEG_00251	9.42e-28	WQ51_02665	-	-	S	-	-	-	Protein of unknown function (DUF3042)
APPLDMEG_00254	2.33e-74	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
APPLDMEG_00255	1e-270	eriC	-	-	P	ko:K03281	-	ko00000	Chloride transporter ClC family
APPLDMEG_00256	9.78e-52	pheA	1.3.1.12, 2.3.1.79, 4.2.1.51, 5.4.99.5	-	E	ko:K00661,ko:K04092,ko:K04093,ko:K04516,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase
APPLDMEG_00257	0.0	eriC	-	-	P	ko:K03281	-	ko00000	Chloride transporter, ClC family
APPLDMEG_00258	3.48e-98	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
APPLDMEG_00259	2.52e-26	XK27_08880	-	-	-	-	-	-	-
APPLDMEG_00260	3.12e-162	XK27_08875	-	-	O	-	-	-	Zinc-dependent metalloprotease
APPLDMEG_00261	2.94e-191	estA	-	CE1	S	ko:K03930	-	ko00000,ko01000	Esterase
APPLDMEG_00262	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APPLDMEG_00263	3.8e-174	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00264	1.37e-190	XK27_08840	-	-	S	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
APPLDMEG_00265	1.38e-228	-	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter substrate binding protein
APPLDMEG_00267	0.0	crpB	-	-	Q	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_00268	4.13e-165	yycF	-	-	KT	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APPLDMEG_00269	1.75e-311	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
APPLDMEG_00270	1.46e-196	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Metal-dependent hydrolases of the beta-lactamase superfamily I
APPLDMEG_00271	4.46e-74	-	-	-	S	ko:K09790	-	ko00000	Protein of unknown function (DUF454)
APPLDMEG_00272	5.57e-289	femX	2.3.2.10, 2.3.2.16	-	V	ko:K05363,ko:K11693	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	protein involved in methicillin resistance
APPLDMEG_00273	1.89e-187	XK27_00835	-	-	S	-	-	-	hydrolases of the HAD superfamily
APPLDMEG_00274	8.28e-177	XK27_00115	-	-	K	-	-	-	Acetyltransferase GNAT family
APPLDMEG_00275	1.86e-170	-	-	-	F	-	-	-	Phosphorylase superfamily
APPLDMEG_00276	8.36e-90	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
APPLDMEG_00277	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	cation transport ATPase
APPLDMEG_00278	6.77e-166	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
APPLDMEG_00279	1.27e-196	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
APPLDMEG_00280	4.75e-267	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APPLDMEG_00281	1.79e-230	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APPLDMEG_00282	8.67e-160	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
APPLDMEG_00283	8.45e-211	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
APPLDMEG_00284	5.85e-119	mutX	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NTP pyrophosphohydrolases including oxidative damage repair enzymes
APPLDMEG_00285	2.22e-234	XK27_05220	-	-	S	-	-	-	permease
APPLDMEG_00286	5.71e-282	XK27_05225	-	-	G	-	-	-	COG0457 FOG TPR repeat
APPLDMEG_00287	1.8e-123	sipC	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
APPLDMEG_00288	3.6e-31	-	-	-	-	-	-	-	-
APPLDMEG_00289	1.55e-275	-	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
APPLDMEG_00290	0.0	yheS_2	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ATPase components of ABC transporters with duplicated ATPase domains
APPLDMEG_00291	8.78e-67	-	-	-	-	-	-	-	-
APPLDMEG_00292	7.32e-79	-	-	-	-	-	-	-	-
APPLDMEG_00293	4.1e-73	-	-	-	-	-	-	-	-
APPLDMEG_00294	8.46e-50	uvrX	2.7.7.7	-	L	ko:K02346,ko:K03502,ko:K14161	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APPLDMEG_00295	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
APPLDMEG_00296	4.62e-81	-	-	-	K	ko:K21903	-	ko00000,ko03000	Transcriptional regulator
APPLDMEG_00297	4.19e-68	XK27_05385	-	-	P	ko:K07238	-	ko00000,ko02000	Mediates zinc uptake. May also transport other divalent cations
APPLDMEG_00298	1.39e-101	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	Mediates zinc uptake. May also transport other divalent cations
APPLDMEG_00300	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
APPLDMEG_00301	2.64e-302	agcS	-	-	E	ko:K03310	-	ko00000	(Alanine) symporter
APPLDMEG_00302	1.34e-311	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APPLDMEG_00303	5.63e-218	bglC	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_00304	0.0	sasH	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
APPLDMEG_00305	2.19e-103	yckA	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00306	3.96e-191	yckB	-	-	ET	ko:K02030,ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
APPLDMEG_00307	3.53e-300	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
APPLDMEG_00308	2.51e-144	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APPLDMEG_00309	9.75e-162	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
APPLDMEG_00310	7.65e-223	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
APPLDMEG_00311	2.21e-185	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
APPLDMEG_00312	6.55e-120	thiJ	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1 family
APPLDMEG_00313	6.18e-171	-	-	-	S	-	-	-	TraX protein
APPLDMEG_00314	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
APPLDMEG_00315	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
APPLDMEG_00316	5.25e-297	dinF	-	-	V	-	-	-	Mate efflux family protein
APPLDMEG_00317	3.49e-221	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type enterochelin transport system, periplasmic component
APPLDMEG_00318	0.0	-	-	-	V	-	-	-	Type III restriction enzyme, res subunit
APPLDMEG_00319	1.54e-140	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD hydrolase, family IA, variant 1
APPLDMEG_00320	1.75e-180	-	-	-	F	-	-	-	Phosphorylase superfamily
APPLDMEG_00321	2.41e-141	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
APPLDMEG_00322	1.42e-230	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
APPLDMEG_00323	5.15e-161	ybhF_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00324	3.33e-185	-	-	-	G	-	-	-	protein with an alpha beta hydrolase fold
APPLDMEG_00325	8.14e-151	spxB	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
APPLDMEG_00326	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
APPLDMEG_00327	7.29e-84	-	-	-	S	-	-	-	cog cog4633
APPLDMEG_00328	5.8e-85	copY	-	-	K	-	-	-	Copper transport repressor, CopY TcrY family
APPLDMEG_00329	2.15e-238	adhB	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Dehydrogenase
APPLDMEG_00330	1.02e-241	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
APPLDMEG_00331	2.67e-197	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
APPLDMEG_00332	3.82e-122	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
APPLDMEG_00333	1.05e-76	-	-	-	S	-	-	-	Protein of unknown function with HXXEE motif
APPLDMEG_00334	7.03e-51	-	-	-	-	-	-	-	-
APPLDMEG_00335	3.48e-189	-	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
APPLDMEG_00336	1.06e-192	-	-	-	I	-	-	-	Alpha/beta hydrolase family
APPLDMEG_00337	1.25e-224	-	-	-	C	-	-	-	nadph quinone reductase
APPLDMEG_00338	1.49e-88	-	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_00339	3.84e-79	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
APPLDMEG_00340	2.82e-192	-	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_00341	4.67e-200	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPase activity
APPLDMEG_00342	2.94e-168	-	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
APPLDMEG_00343	1.01e-125	-	-	-	T	ko:K16923	-	ko00000,ko00002,ko02000	Psort location CytoplasmicMembrane, score
APPLDMEG_00344	5.6e-178	-	-	-	S	-	-	-	Phenazine biosynthesis protein
APPLDMEG_00345	0.0	proWX	-	-	P	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
APPLDMEG_00346	1.21e-164	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00347	6.22e-186	-	-	-	GM	-	-	-	NmrA family
APPLDMEG_00348	5.7e-89	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
APPLDMEG_00349	1.75e-168	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Belongs to the alpha-acetolactate decarboxylase family
APPLDMEG_00350	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
APPLDMEG_00353	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
APPLDMEG_00355	6.3e-174	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	Acetoin reductase
APPLDMEG_00356	2.56e-56	-	-	-	P	-	-	-	Rhodanese-like protein
APPLDMEG_00357	7.33e-94	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
APPLDMEG_00358	2.14e-282	XK27_05470	-	-	E	-	-	-	Methionine synthase
APPLDMEG_00359	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APPLDMEG_00360	1.44e-281	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
APPLDMEG_00361	3.84e-153	spaR	-	-	KT	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
APPLDMEG_00362	1.23e-190	-	-	-	S	-	-	-	TraX protein
APPLDMEG_00365	4.38e-106	-	-	-	V	ko:K01990,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
APPLDMEG_00366	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APPLDMEG_00367	3.87e-201	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
APPLDMEG_00368	1.2e-196	-	-	-	GK	-	-	-	ROK family
APPLDMEG_00369	6.04e-173	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APPLDMEG_00370	3.44e-202	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APPLDMEG_00371	1.51e-164	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
APPLDMEG_00372	9.06e-108	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
APPLDMEG_00373	4.99e-107	-	-	-	-	ko:K16788	-	ko00000,ko02000	-
APPLDMEG_00374	0.0	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APPLDMEG_00375	9.91e-72	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APPLDMEG_00376	1.5e-161	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
APPLDMEG_00377	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
APPLDMEG_00378	2.34e-128	-	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
APPLDMEG_00379	4.91e-241	adhP	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
APPLDMEG_00380	1.2e-59	-	-	-	-	-	-	-	-
APPLDMEG_00381	4.14e-66	-	-	-	-	-	-	-	-
APPLDMEG_00382	0.0	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APPLDMEG_00383	5.91e-198	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
APPLDMEG_00384	5.91e-143	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00385	1.67e-135	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00386	7.1e-78	phnA	-	-	P	ko:K06193	ko01120,map01120	ko00000	Alkylphosphonate utilization operon protein PhnA
APPLDMEG_00387	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APPLDMEG_00388	3.61e-213	cpsY	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_00389	9.73e-165	-	-	CBM50	NU	ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	muramidase
APPLDMEG_00390	2.05e-215	yeiH	-	-	S	-	-	-	Membrane
APPLDMEG_00393	0.0	adcA	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
APPLDMEG_00394	9.64e-183	XK27_10720	-	-	D	-	-	-	peptidase activity
APPLDMEG_00395	0.0	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
APPLDMEG_00396	6.93e-207	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
APPLDMEG_00397	2.14e-232	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
APPLDMEG_00398	9.9e-208	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
APPLDMEG_00399	1e-171	yejC	-	-	S	-	-	-	cyclic nucleotide-binding protein
APPLDMEG_00400	9.85e-297	-	-	-	D	-	-	-	nuclear chromosome segregation
APPLDMEG_00401	5.6e-123	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily
APPLDMEG_00402	1.24e-172	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
APPLDMEG_00403	4.76e-105	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
APPLDMEG_00404	1.3e-159	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APPLDMEG_00405	9.11e-84	aldR	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	endoribonuclease L-PSP
APPLDMEG_00406	5.74e-252	pmrB	-	-	EGP	-	-	-	Major Facilitator Superfamily
APPLDMEG_00408	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
APPLDMEG_00409	9.44e-273	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
APPLDMEG_00410	5.57e-99	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
APPLDMEG_00411	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
APPLDMEG_00412	2.41e-145	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
APPLDMEG_00413	5.53e-216	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
APPLDMEG_00414	9.03e-236	mglC	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
APPLDMEG_00415	0.0	mglA	3.6.3.17	-	S	ko:K02056,ko:K06400	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_00416	2.01e-244	-	-	-	S	ko:K07335	-	ko00000	membrane
APPLDMEG_00417	4.77e-82	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
APPLDMEG_00418	1.17e-143	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APPLDMEG_00419	3.49e-290	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
APPLDMEG_00420	5.11e-133	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase small domain protein
APPLDMEG_00421	8.59e-217	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
APPLDMEG_00422	1.25e-39	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
APPLDMEG_00423	5.82e-299	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
APPLDMEG_00424	6.86e-154	ciaR	-	-	T	ko:K14983	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APPLDMEG_00425	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
APPLDMEG_00426	4.22e-145	coaB	6.3.2.5	-	H	ko:K21977	ko00770,map00770	ko00000,ko00001,ko00002,ko01000	Phosphopantothenate-cysteine ligase
APPLDMEG_00427	8.28e-118	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APPLDMEG_00428	1.24e-119	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
APPLDMEG_00429	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
APPLDMEG_00430	9.94e-210	metF	1.5.1.20	-	E	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	reductase
APPLDMEG_00431	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APPLDMEG_00433	0.0	pabB	2.6.1.85, 4.1.3.38	-	EH	ko:K01665,ko:K03342,ko:K13950	ko00790,map00790	ko00000,ko00001,ko01000,ko01007	component I
APPLDMEG_00434	2.39e-142	-	-	-	F	-	-	-	TRSP domain C terminus to PRTase_2
APPLDMEG_00435	1.1e-182	-	-	-	J	-	-	-	Phosphoribosyl transferase (PRTase)
APPLDMEG_00436	1.19e-250	yceG	-	-	S	-	-	-	Putative component of 'biosynthetic module'
APPLDMEG_00437	7.48e-211	yceH	-	-	P	-	-	-	Belongs to the TelA family
APPLDMEG_00438	1.79e-116	-	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
APPLDMEG_00439	3.08e-100	-	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
APPLDMEG_00440	1.46e-114	-	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
APPLDMEG_00441	0.0	-	3.6.3.2, 3.6.3.6, 3.6.3.8	-	P	ko:K01531,ko:K01535,ko:K01537	ko00190,map00190	ko00000,ko00001,ko01000	cation transport ATPase
APPLDMEG_00442	1.36e-93	-	-	-	S	-	-	-	hydrolases of the HAD superfamily
APPLDMEG_00443	8.96e-114	-	-	-	G	-	-	-	Citrate lyase beta subunit
APPLDMEG_00444	1.4e-298	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APPLDMEG_00445	5.82e-47	dltC	6.1.1.13	-	IQ	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APPLDMEG_00446	1.7e-300	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Membrane protein involved in D-alanine export
APPLDMEG_00447	0.0	dltA	6.1.1.13	-	Q	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
APPLDMEG_00448	0.0	XK27_10035	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_00449	0.0	yfiB1	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_00450	8.77e-128	pvaA	-	-	M	ko:K02395	-	ko00000,ko02035	lytic transglycosylase activity
APPLDMEG_00451	1.82e-229	-	-	-	S	-	-	-	37-kD nucleoid-associated bacterial protein
APPLDMEG_00452	1.09e-292	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APPLDMEG_00453	4.85e-131	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
APPLDMEG_00454	4.78e-185	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
APPLDMEG_00455	1.86e-246	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APPLDMEG_00456	6e-142	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
APPLDMEG_00457	4.47e-231	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APPLDMEG_00458	4.17e-192	gst	-	-	O	ko:K11209	-	ko00000,ko01000	Glutathione S-transferase
APPLDMEG_00459	1.96e-223	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	domain protein
APPLDMEG_00460	5.14e-217	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
APPLDMEG_00461	3.52e-61	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	50S ribosomal protein L31
APPLDMEG_00462	2.03e-290	mntH_2	-	-	P	-	-	-	Mn2 and Fe2 transporters of the NRAMP family
APPLDMEG_00463	8.99e-208	ypuA	-	-	S	-	-	-	secreted protein
APPLDMEG_00464	1.29e-94	ywkD	-	-	E	ko:K08234	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
APPLDMEG_00465	6.26e-169	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase (surface protein transpeptidase)
APPLDMEG_00466	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPLDMEG_00467	7.17e-233	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
APPLDMEG_00468	0.0	noxE	-	-	P	-	-	-	NADH oxidase
APPLDMEG_00469	0.0	yheS_1	-	-	S	-	-	-	abc transporter atp-binding protein
APPLDMEG_00470	6.01e-104	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
APPLDMEG_00471	1.34e-179	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Belongs to the pyridoxine kinase family
APPLDMEG_00472	3.86e-108	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
APPLDMEG_00474	5.49e-300	ycxD	-	-	K	-	-	-	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
APPLDMEG_00475	6.52e-75	nrdD_1	1.1.98.6, 1.17.4.1	-	F	ko:K00525,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Ribonucleoside-triphosphate reductase
APPLDMEG_00477	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APPLDMEG_00478	5.09e-119	XK27_03150	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APPLDMEG_00479	2.78e-251	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APPLDMEG_00480	3.7e-32	WQ51_00220	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
APPLDMEG_00481	9.75e-101	-	-	-	S	-	-	-	Protein of unknown function (DUF3278)
APPLDMEG_00482	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
APPLDMEG_00483	2.16e-159	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
APPLDMEG_00484	1.09e-223	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APPLDMEG_00485	5.02e-255	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APPLDMEG_00486	1.45e-152	-	-	-	L	-	-	-	DNA alkylation repair enzyme
APPLDMEG_00487	0.0	clsA_1	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APPLDMEG_00488	8.38e-113	pat	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	acetyltransferase
APPLDMEG_00489	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APPLDMEG_00490	2.27e-192	-	-	-	L	-	-	-	PFAM Integrase catalytic region
APPLDMEG_00491	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
APPLDMEG_00492	6.34e-48	-	-	-	P	ko:K10716	-	ko00000,ko02000	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APPLDMEG_00493	3.2e-49	-	-	-	L	-	-	-	RePlication protein
APPLDMEG_00494	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
APPLDMEG_00495	1.3e-126	yfnB	3.8.1.2	-	E	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	hydrolase
APPLDMEG_00496	4.98e-24	yfnB	3.8.1.2	-	E	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	hydrolase
APPLDMEG_00497	9.02e-154	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
APPLDMEG_00498	1.31e-188	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
APPLDMEG_00499	3.89e-156	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
APPLDMEG_00500	3.85e-156	tktN	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	1-deoxy-D-xylulose-5-phosphate synthase
APPLDMEG_00501	3.67e-282	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
APPLDMEG_00502	1.45e-56	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system galactitol-specific IIB component
APPLDMEG_00503	6.42e-278	-	-	-	GKT	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
APPLDMEG_00504	0.0	-	3.2.1.80	-	G	ko:K03332	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
APPLDMEG_00505	2.8e-203	yjlA	-	-	EG	-	-	-	membrane
APPLDMEG_00506	1.07e-106	-	-	-	S	-	-	-	RDD family
APPLDMEG_00507	5.24e-165	-	-	-	K	ko:K20342,ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_00508	1.06e-193	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_00509	2.7e-133	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
APPLDMEG_00510	2.01e-181	-	-	-	K	ko:K20342,ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_00511	1.61e-59	-	-	-	-	-	-	-	-
APPLDMEG_00512	5.5e-49	yfiQ	-	-	K	ko:K09181	-	ko00000	-acetyltransferase
APPLDMEG_00513	2.21e-182	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
APPLDMEG_00514	1.27e-182	M1-956	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
APPLDMEG_00515	7.81e-238	-	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00518	1.49e-112	yfjR	-	-	K	-	-	-	regulation of single-species biofilm formation
APPLDMEG_00519	2.45e-147	-	-	-	S	-	-	-	Protein of unknown function DUF262
APPLDMEG_00520	6.83e-260	-	-	-	S	-	-	-	Protein of unknown function DUF262
APPLDMEG_00521	9.85e-133	desR	-	-	K	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APPLDMEG_00522	2.21e-236	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
APPLDMEG_00523	5.85e-170	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
APPLDMEG_00524	2.52e-204	XK27_09825	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00527	3.06e-212	yocS	-	-	S	ko:K03453	-	ko00000	Transporter
APPLDMEG_00528	1.16e-106	-	-	-	F	-	-	-	cytidine deaminase activity
APPLDMEG_00529	1.67e-25	-	-	-	P	-	-	-	ABC transporter transmembrane region
APPLDMEG_00530	5.32e-41	-	-	-	M	ko:K07114	-	ko00000,ko02000	translation initiation factor activity
APPLDMEG_00532	1.45e-21	-	-	-	-	-	-	-	-
APPLDMEG_00533	3.05e-55	-	-	-	-	-	-	-	-
APPLDMEG_00534	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF2971)
APPLDMEG_00535	7.28e-97	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APPLDMEG_00536	4.95e-37	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
APPLDMEG_00537	5.94e-198	-	-	-	-	-	-	-	-
APPLDMEG_00538	7.82e-34	-	-	-	F	-	-	-	cytidine deaminase activity
APPLDMEG_00539	5.18e-148	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transporter
APPLDMEG_00540	6.35e-198	XK27_09825	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00543	1.67e-120	XK27_05000	-	-	S	ko:K06940	-	ko00000	metal cluster binding
APPLDMEG_00544	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
APPLDMEG_00545	4.97e-170	yxdL	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_00546	6.75e-220	-	-	-	T	-	-	-	Histidine kinase
APPLDMEG_00547	3.69e-159	graR	-	-	KT	ko:K19082	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APPLDMEG_00548	1.25e-127	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
APPLDMEG_00549	9.87e-283	pbuX	-	-	F	ko:K16169	-	ko00000,ko02000	xanthine permease
APPLDMEG_00550	0.0	-	-	-	V	ko:K06148	-	ko00000,ko02000	(ABC) transporter
APPLDMEG_00551	2.27e-183	-	-	-	K	ko:K20373	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_00552	5.45e-312	norM	-	-	V	ko:K03327	-	ko00000,ko02000	Multidrug efflux pump
APPLDMEG_00554	7.43e-229	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APPLDMEG_00556	8.92e-39	-	-	-	T	-	-	-	A nuclease of the HNH/ENDO VII superfamily with conserved WHH
APPLDMEG_00557	0.0	-	-	-	S	-	-	-	Domain of unknown function DUF87
APPLDMEG_00558	1.34e-153	-	-	-	T	-	-	-	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APPLDMEG_00559	1.67e-291	brnQ	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
APPLDMEG_00560	1.44e-229	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
APPLDMEG_00561	4.97e-79	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
APPLDMEG_00562	4.07e-130	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
APPLDMEG_00563	2.15e-27	csbD	-	-	K	-	-	-	CsbD-like
APPLDMEG_00564	1.33e-148	-	-	-	S	-	-	-	Carbohydrate-binding domain-containing protein Cthe_2159
APPLDMEG_00565	8.43e-67	-	-	-	P	-	-	-	Protein conserved in bacteria
APPLDMEG_00566	8.6e-283	yfnA	-	-	E	ko:K03294	-	ko00000	amino acid
APPLDMEG_00567	0.0	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00568	9.34e-176	tcyC2	-	-	E	ko:K10010,ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00569	1.12e-145	-	-	-	P	ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, permease protein
APPLDMEG_00570	1.59e-146	-	-	-	P	ko:K16958	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00571	1.17e-211	-	-	-	ET	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
APPLDMEG_00572	6.52e-226	-	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen decarboxylase (URO-D)
APPLDMEG_00573	1.18e-109	gpo	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
APPLDMEG_00574	1.97e-56	-	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
APPLDMEG_00577	1.46e-261	-	-	-	P	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
APPLDMEG_00578	1.75e-157	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00579	1.09e-124	-	-	-	K	-	-	-	WHG domain
APPLDMEG_00580	1.27e-220	ydhF	-	-	S	-	-	-	Aldo keto reductase
APPLDMEG_00581	9.94e-142	XK27_02070	-	-	S	ko:K07078	-	ko00000	nitroreductase
APPLDMEG_00582	6.1e-192	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
APPLDMEG_00583	1.36e-96	ywnA_2	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_00584	5.43e-196	-	-	-	E	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
APPLDMEG_00585	2.85e-286	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
APPLDMEG_00586	7.61e-217	bcrA	-	-	V	ko:K01990,ko:K19309	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00587	1.72e-165	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
APPLDMEG_00588	4.75e-57	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
APPLDMEG_00589	4.78e-192	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
APPLDMEG_00590	3.41e-160	-	-	-	T	-	-	-	Xre family transcriptional regulator
APPLDMEG_00591	2.05e-139	yodC	-	-	C	-	-	-	nitroreductase
APPLDMEG_00592	1.36e-143	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
APPLDMEG_00593	2.2e-51	-	-	-	DJ	ko:K06218	-	ko00000,ko02048	nuclease activity
APPLDMEG_00594	2.97e-41	XK27_10490	-	-	-	-	-	-	-
APPLDMEG_00595	4.18e-201	yvgN	-	-	C	-	-	-	reductase
APPLDMEG_00596	6.02e-269	-	-	-	S	-	-	-	Tetratricopeptide repeat
APPLDMEG_00597	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	-beta-galactosidase
APPLDMEG_00598	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	transporter
APPLDMEG_00599	1.97e-256	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
APPLDMEG_00600	4.24e-248	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
APPLDMEG_00601	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDPglucose--hexose-1-phosphate uridylyltransferase
APPLDMEG_00602	2.71e-281	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APPLDMEG_00603	1.52e-192	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
APPLDMEG_00604	1.32e-63	isplu5A	-	-	L	ko:K07491	-	ko00000	COG1943 Transposase and inactivated derivatives
APPLDMEG_00605	0.0	dexB	3.2.1.70	-	G	ko:K01215	-	ko00000,ko01000	COG0366 Glycosidases
APPLDMEG_00606	4.07e-288	vncS	2.7.13.3	-	T	ko:K10819	-	ko00000,ko01000	Histidine kinase
APPLDMEG_00607	1.5e-149	vncR	-	-	K	-	-	-	Response regulator receiver domain protein
APPLDMEG_00608	1.52e-302	vex3	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	Efflux ABC transporter, permease protein
APPLDMEG_00609	7.15e-140	vex2	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00610	8.38e-265	vex1	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	Efflux ABC transporter, permease protein
APPLDMEG_00611	0.0	XK27_07020	-	-	S	-	-	-	Belongs to the UPF0371 family
APPLDMEG_00613	7e-250	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	glycerol dehydrogenase
APPLDMEG_00614	3.53e-228	XK27_10475	-	-	S	-	-	-	oxidoreductase
APPLDMEG_00615	1.65e-76	dhaM	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	dihydroxyacetone kinase, phosphotransfer subunit
APPLDMEG_00616	1.84e-119	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dihydroxyacetone kinase
APPLDMEG_00617	5.61e-226	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dihydroxyacetone kinase
APPLDMEG_00618	2.56e-289	-	-	-	K	-	-	-	Psort location CytoplasmicMembrane, score
APPLDMEG_00619	0.0	tcdB	-	-	M	ko:K11063	ko02024,map02024	ko00000,ko00001,ko02042	Putative cell wall binding repeat
APPLDMEG_00620	1.37e-171	-	-	-	T	-	-	-	Ser Thr phosphatase family protein
APPLDMEG_00621	2.74e-46	-	-	-	S	-	-	-	Immunity protein 41
APPLDMEG_00622	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
APPLDMEG_00625	5.44e-15	-	-	-	S	-	-	-	integral membrane protein
APPLDMEG_00626	1.21e-58	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
APPLDMEG_00627	4.96e-146	yhfC	-	-	S	-	-	-	Putative membrane peptidase family (DUF2324)
APPLDMEG_00628	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_00630	0.0	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00631	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_00632	4.11e-71	tcdB	-	-	M	ko:K11063	ko02024,map02024	ko00000,ko00001,ko02042	Putative cell wall binding repeat
APPLDMEG_00634	9.65e-305	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00635	1.24e-299	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00636	3.71e-98	tcdB	-	-	M	ko:K11063	ko02024,map02024	ko00000,ko00001,ko02042	Putative cell wall binding repeat
APPLDMEG_00637	6.97e-248	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00638	1.07e-130	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
APPLDMEG_00639	8.33e-200	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
APPLDMEG_00640	0.0	tcdB	-	-	M	ko:K11063	ko02024,map02024	ko00000,ko00001,ko02042	Putative cell wall binding repeat
APPLDMEG_00641	0.0	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00642	2.55e-245	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00643	0.0	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00644	1.56e-289	-	-	-	S	-	-	-	dextransucrase activity
APPLDMEG_00646	2.53e-109	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APPLDMEG_00647	4.8e-204	mleP	-	-	S	ko:K07088	-	ko00000	Sodium Bile acid symporter family
APPLDMEG_00648	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme, NAD binding domain
APPLDMEG_00649	8.4e-64	-	-	-	K	-	-	-	Helix-turn-helix
APPLDMEG_00650	1.57e-151	mleR	-	-	K	-	-	-	malolactic fermentation system
APPLDMEG_00651	4.78e-152	-	-	-	S	-	-	-	CAAX protease self-immunity
APPLDMEG_00652	1.67e-270	-	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	Major facilitator Superfamily
APPLDMEG_00653	4.52e-82	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
APPLDMEG_00654	7.02e-122	maa	2.3.1.79	-	GK	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
APPLDMEG_00655	1.51e-78	-	2.7.13.3	-	T	ko:K10681,ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
APPLDMEG_00656	7.78e-93	nisR	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
APPLDMEG_00658	1.78e-17	-	-	-	-	-	-	-	-
APPLDMEG_00659	1.23e-112	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00660	0.0	-	3.5.1.28	-	M	ko:K01448,ko:K13733,ko:K20276	ko01503,ko02024,ko05100,map01503,map02024,map05100	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	domain protein
APPLDMEG_00661	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_00666	8.31e-159	XK27_07620	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00667	2e-34	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00668	1.8e-154	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00669	0.0	rumA	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPLDMEG_00670	1.28e-126	mip	-	-	S	-	-	-	hydroperoxide reductase activity
APPLDMEG_00671	8.66e-254	-	-	-	I	-	-	-	acyl-CoA dehydrogenase
APPLDMEG_00672	2.85e-122	ydiA	-	-	P	ko:K11041	ko05150,map05150	ko00000,ko00001,ko02042	C4-dicarboxylate transporter malic acid transport
APPLDMEG_00673	0.0	msrR	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_00674	2.42e-197	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
APPLDMEG_00675	6.53e-113	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APPLDMEG_00676	2.93e-298	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
APPLDMEG_00677	6.02e-219	hicD2	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
APPLDMEG_00678	2.99e-71	XK26_04240	-	-	S	-	-	-	Belongs to the UPF0342 family
APPLDMEG_00679	2.62e-262	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
APPLDMEG_00680	1.5e-278	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APPLDMEG_00681	1.14e-254	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APPLDMEG_00682	1.56e-194	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APPLDMEG_00683	4.8e-150	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
APPLDMEG_00684	5.2e-274	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
APPLDMEG_00685	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
APPLDMEG_00686	4.48e-34	WQ51_00785	-	-	-	-	-	-	-
APPLDMEG_00687	6.13e-315	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
APPLDMEG_00688	2.24e-96	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
APPLDMEG_00689	5.51e-245	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
APPLDMEG_00690	1.59e-245	XK27_07735	-	-	S	-	-	-	YjbR
APPLDMEG_00691	3.69e-233	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	Catabolite control protein A
APPLDMEG_00692	2e-244	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Belongs to the peptidase M24B family
APPLDMEG_00693	1.17e-84	yugI	-	-	J	ko:K07570	-	ko00000	RNA binding protein, contains ribosomal protein S1 domain
APPLDMEG_00694	0.0	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APPLDMEG_00695	1.98e-105	smpB	-	-	O	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
APPLDMEG_00696	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
APPLDMEG_00697	1.06e-44	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
APPLDMEG_00698	1.46e-281	pmrA	-	-	EGP	ko:K08161	-	ko00000,ko02000	Major Facilitator
APPLDMEG_00699	2.13e-121	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APPLDMEG_00700	2.03e-184	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
APPLDMEG_00701	1.16e-212	era	-	-	M	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APPLDMEG_00702	8.52e-86	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
APPLDMEG_00703	3.1e-112	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APPLDMEG_00704	2.92e-138	licT	-	-	K	ko:K03488	-	ko00000,ko03000	antiterminator
APPLDMEG_00705	1.59e-11	licT	-	-	K	ko:K03488	-	ko00000,ko03000	antiterminator
APPLDMEG_00706	1.85e-136	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APPLDMEG_00707	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
APPLDMEG_00708	3.79e-187	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APPLDMEG_00709	7.77e-199	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APPLDMEG_00710	1.2e-189	-	-	-	I	-	-	-	Alpha/beta hydrolase family
APPLDMEG_00711	2.42e-12	-	-	-	-	-	-	-	-
APPLDMEG_00712	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
APPLDMEG_00713	1.01e-100	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA domain protein
APPLDMEG_00714	2.57e-168	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00715	2.2e-151	-	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
APPLDMEG_00716	3.31e-47	ykuJ	-	-	S	-	-	-	protein conserved in bacteria
APPLDMEG_00717	2.61e-234	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APPLDMEG_00718	0.0	clpE	-	-	O	ko:K03697	-	ko00000,ko03110	Belongs to the ClpA ClpB family
APPLDMEG_00719	4.35e-108	XK27_09440	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
APPLDMEG_00720	2.23e-65	XK27_09445	-	-	S	-	-	-	Domain of unknown function (DUF1827)
APPLDMEG_00721	1.42e-219	-	-	-	S	-	-	-	oxidoreductase
APPLDMEG_00722	9.63e-289	murN	-	-	V	ko:K12554	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	FemAB family
APPLDMEG_00723	1.04e-145	-	-	-	M	-	-	-	Pfam SNARE associated Golgi protein
APPLDMEG_00724	5.05e-138	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3862)
APPLDMEG_00727	9.51e-268	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein S1
APPLDMEG_00730	1.15e-20	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
APPLDMEG_00731	2.04e-254	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
APPLDMEG_00732	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APPLDMEG_00735	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
APPLDMEG_00736	3.66e-139	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
APPLDMEG_00737	1.23e-18	-	-	-	L	-	-	-	Helix-hairpin-helix DNA-binding motif class 1
APPLDMEG_00738	3.14e-42	-	-	-	S	-	-	-	Domain of unknown function (DUF1912)
APPLDMEG_00739	9.55e-216	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	Homocysteine
APPLDMEG_00740	0.0	lysP	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
APPLDMEG_00741	9.58e-144	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
APPLDMEG_00742	8.89e-288	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APPLDMEG_00743	2.97e-30	-	-	-	-	-	-	-	-
APPLDMEG_00744	7.88e-116	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APPLDMEG_00745	4.06e-211	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APPLDMEG_00746	4.06e-267	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	synthase
APPLDMEG_00747	1.17e-286	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
APPLDMEG_00748	2.54e-101	-	-	-	K	-	-	-	hmm pf08876
APPLDMEG_00749	3.52e-152	hly-III	-	-	K	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
APPLDMEG_00750	1.64e-39	pspC	-	-	KT	-	-	-	PspC domain protein
APPLDMEG_00751	9.01e-255	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
APPLDMEG_00752	9.84e-206	-	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
APPLDMEG_00753	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APPLDMEG_00755	9.4e-313	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
APPLDMEG_00756	1.65e-240	dgs	2.4.1.208	GT4	M	ko:K13677	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
APPLDMEG_00757	0.0	-	-	-	M	ko:K02460	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	domain protein
APPLDMEG_00758	2.1e-151	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APPLDMEG_00759	2.55e-42	-	-	-	-	-	-	-	-
APPLDMEG_00760	8.64e-125	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	AdP-ribose pyrophosphatase
APPLDMEG_00761	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APPLDMEG_00762	0.0	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
APPLDMEG_00763	2.31e-232	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
APPLDMEG_00764	8.35e-213	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
APPLDMEG_00765	5.15e-219	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
APPLDMEG_00766	3.89e-187	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
APPLDMEG_00767	1.37e-128	-	-	-	J	ko:K09962	-	ko00000	protein conserved in bacteria
APPLDMEG_00768	4.18e-315	merA	-	-	C	-	-	-	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APPLDMEG_00769	8.74e-155	-	-	-	E	-	-	-	Alpha beta hydrolase
APPLDMEG_00771	5.21e-254	ald	1.4.1.1	-	C	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
APPLDMEG_00772	3e-274	hipO2	-	-	E	ko:K01436,ko:K21613	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
APPLDMEG_00773	1.14e-178	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
APPLDMEG_00774	1.08e-147	-	-	-	S	-	-	-	VIT family
APPLDMEG_00775	3.84e-185	-	-	-	F	-	-	-	Phosphorylase superfamily
APPLDMEG_00776	4.32e-28	-	-	-	-	-	-	-	-
APPLDMEG_00777	3.55e-39	XK27_00085	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional
APPLDMEG_00778	2.76e-250	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
APPLDMEG_00779	3.65e-158	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
APPLDMEG_00780	2.28e-250	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APPLDMEG_00781	0.0	lmrA	-	-	V	ko:K06147,ko:K18888	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00782	0.0	msbA_1	-	-	V	ko:K18887	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00783	5.32e-184	-	-	-	L	-	-	-	Phage integrase SAM-like domain
APPLDMEG_00784	4.62e-23	-	-	-	S	-	-	-	Domain of unknown function (DUF3173)
APPLDMEG_00787	1.11e-88	-	-	-	-	-	-	-	-
APPLDMEG_00789	1.6e-121	amiB	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-Acetylmuramoyl-L-alanine amidase
APPLDMEG_00791	2.99e-43	-	-	-	D	-	-	-	LPXTG cell wall anchor motif
APPLDMEG_00792	8.65e-51	-	-	-	K	-	-	-	Helix-turn-helix
APPLDMEG_00794	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
APPLDMEG_00795	2.51e-202	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
APPLDMEG_00797	5.81e-228	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
APPLDMEG_00798	0.0	-	-	-	S	-	-	-	hydrolases of the HAD superfamily
APPLDMEG_00799	2.78e-174	yebC	-	-	M	-	-	-	Membrane
APPLDMEG_00800	0.0	-	-	-	KT	-	-	-	response to antibiotic
APPLDMEG_00801	5.33e-98	-	-	-	K	-	-	-	LytTr DNA-binding domain
APPLDMEG_00802	1.67e-153	-	-	-	S	-	-	-	membrane
APPLDMEG_00803	2.62e-95	mccF	-	-	V	-	-	-	LD-carboxypeptidase
APPLDMEG_00804	1.06e-57	-	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
APPLDMEG_00805	3.94e-250	mccF	-	-	V	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_00806	0.0	-	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	MreB/Mbl protein
APPLDMEG_00808	2.4e-186	-	-	-	V	ko:K21397	-	ko00000,ko02000	Psort location CytoplasmicMembrane, score
APPLDMEG_00811	8.46e-15	-	-	-	-	-	-	-	-
APPLDMEG_00812	2.25e-286	dcuS	2.7.13.3	-	T	ko:K02476,ko:K07701,ko:K07706,ko:K11614	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_00813	8.69e-297	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_00814	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APPLDMEG_00815	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
APPLDMEG_00816	4.24e-162	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
APPLDMEG_00817	4.29e-171	ecsA_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00818	0.0	XK27_00765	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
APPLDMEG_00819	9.65e-180	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APPLDMEG_00820	1.07e-283	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APPLDMEG_00821	3.8e-78	-	-	-	J	-	-	-	Membrane
APPLDMEG_00822	5.57e-81	-	-	-	J	-	-	-	Protein of unknown function (DUF805)
APPLDMEG_00823	3.18e-55	-	-	-	J	-	-	-	Protein of unknown function (DUF805)
APPLDMEG_00826	1.29e-88	-	-	-	-	-	-	-	-
APPLDMEG_00828	2.67e-222	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
APPLDMEG_00829	5.32e-60	ftsL	-	-	D	-	-	-	cell division protein FtsL
APPLDMEG_00830	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
APPLDMEG_00831	1.34e-234	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APPLDMEG_00832	1.86e-302	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
APPLDMEG_00833	3.12e-191	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
APPLDMEG_00834	3.74e-160	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
APPLDMEG_00835	1.43e-164	lytTr	-	-	KT	-	-	-	COG3279 Response regulator of the LytR AlgR family
APPLDMEG_00836	1.47e-270	-	-	-	T	-	-	-	GHKL domain
APPLDMEG_00838	2.24e-315	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
APPLDMEG_00839	7.05e-114	yutD	-	-	J	-	-	-	protein conserved in bacteria
APPLDMEG_00840	2.25e-285	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APPLDMEG_00841	1.91e-120	XK27_09885	-	-	V	-	-	-	Glycopeptide antibiotics resistance protein
APPLDMEG_00844	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00845	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00852	4.94e-59	spiA	-	-	K	ko:K18831	-	ko00000,ko02048,ko03000	sequence-specific DNA binding
APPLDMEG_00856	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
APPLDMEG_00857	8.98e-193	gla	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
APPLDMEG_00858	1.08e-121	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
APPLDMEG_00859	1.22e-175	cppA	-	-	E	-	-	-	CppA N-terminal
APPLDMEG_00860	3.76e-217	-	-	-	V	-	-	-	COG1680 Beta-lactamase class C and other penicillin binding proteins
APPLDMEG_00862	2.6e-95	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
APPLDMEG_00863	1.18e-181	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	carbonic anhydrase
APPLDMEG_00864	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	formate acetyltransferase'
APPLDMEG_00865	3.72e-259	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APPLDMEG_00867	9.45e-196	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC-type amino acid transport signal transduction systems, periplasmic component domain
APPLDMEG_00868	7.25e-208	yxeN	-	-	P	ko:K02029,ko:K16959,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00869	2.55e-165	tcyN	3.6.3.21	-	E	ko:K02028,ko:K10010,ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00870	3.64e-14	-	-	-	S	-	-	-	Protein of unknown function (DUF4059)
APPLDMEG_00871	1.13e-218	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
APPLDMEG_00872	2.12e-119	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
APPLDMEG_00873	3.1e-112	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APPLDMEG_00874	1.07e-240	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
APPLDMEG_00875	3.42e-233	ytqA	-	-	S	ko:K07139	-	ko00000	radical SAM protein
APPLDMEG_00876	5.84e-123	mraW1	-	-	J	-	-	-	(SAM)-dependent
APPLDMEG_00878	0.0	nhaP1	-	-	P	ko:K03316	-	ko00000	NhaP-type Na H and K H antiporters
APPLDMEG_00880	1.2e-30	-	-	-	-	-	-	-	-
APPLDMEG_00882	1.38e-180	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00883	2.74e-302	hlyX	-	-	S	ko:K03699	-	ko00000,ko02042	COG1253 Hemolysins and related proteins containing CBS domains
APPLDMEG_00885	4.91e-202	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APPLDMEG_00887	6.2e-98	XK27_03180	-	-	T	-	-	-	universal stress protein
APPLDMEG_00888	4.15e-300	aspC	2.6.1.2, 2.6.1.66	-	E	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
APPLDMEG_00889	2.12e-180	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APPLDMEG_00890	3.53e-129	pncA	-	-	Q	ko:K16788	-	ko00000,ko02000	isochorismatase
APPLDMEG_00891	0.0	ascB	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
APPLDMEG_00892	3.53e-275	-	-	-	M	-	-	-	lipopolysaccharide 3-alpha-galactosyltransferase activity
APPLDMEG_00893	1.7e-202	-	-	-	H	-	-	-	COG0463 Glycosyltransferases involved in cell wall biogenesis
APPLDMEG_00894	3.47e-240	-	-	-	M	-	-	-	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APPLDMEG_00895	3.71e-294	gtf1	-	-	M	-	-	-	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APPLDMEG_00896	7.49e-64	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APPLDMEG_00897	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
APPLDMEG_00898	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APPLDMEG_00899	4.16e-85	-	-	-	-	-	-	-	-
APPLDMEG_00900	7.27e-194	-	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
APPLDMEG_00901	2.61e-127	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
APPLDMEG_00902	3.79e-273	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
APPLDMEG_00903	4.57e-65	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
APPLDMEG_00904	1.85e-151	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APPLDMEG_00905	4.56e-136	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
APPLDMEG_00906	3.42e-77	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
APPLDMEG_00907	7.45e-178	XK27_06665	-	-	Q	-	-	-	Methyltransferase domain protein
APPLDMEG_00908	7.61e-248	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
APPLDMEG_00909	1.88e-52	yefM	-	-	D	ko:K19159	-	ko00000,ko02048	Antitoxin component of a toxin-antitoxin (TA) module
APPLDMEG_00910	4.95e-57	yoeB	-	-	S	ko:K19158	-	ko00000,ko01000,ko02048	Addiction module toxin, Txe YoeB family
APPLDMEG_00911	0.0	clpL	-	-	O	ko:K04086	-	ko00000,ko03110	ATP-dependent Clp protease ATP-binding subunit
APPLDMEG_00915	3.05e-95	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
APPLDMEG_00916	1.18e-168	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00917	2.35e-220	XK27_05910	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	Bacterial ABC transporter protein EcsB
APPLDMEG_00918	2.95e-197	ytmP	-	-	M	-	-	-	Phosphotransferase
APPLDMEG_00919	8.79e-156	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
APPLDMEG_00921	1.86e-285	-	-	-	L	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_00922	2.93e-270	ytfP	-	-	S	ko:K07007	-	ko00000	Flavoprotein
APPLDMEG_00923	0.0	ilvD	4.2.1.9	-	E	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the IlvD Edd family
APPLDMEG_00924	1.09e-83	XK27_02560	-	-	S	-	-	-	cog cog2151
APPLDMEG_00925	5.18e-76	WQ51_02910	-	-	S	-	-	-	Protein of unknown function, DUF536
APPLDMEG_00926	1.86e-135	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
APPLDMEG_00927	1.03e-160	-	-	-	K	-	-	-	transcriptional regulator, MerR family
APPLDMEG_00928	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00929	1.59e-160	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_00931	5.31e-59	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APPLDMEG_00932	4.05e-62	-	-	-	-	-	-	-	-
APPLDMEG_00934	6.89e-06	-	-	-	-	-	-	-	-
APPLDMEG_00935	0.0	-	-	-	-	-	-	-	-
APPLDMEG_00936	0.0	-	2.4.1.12	GT2	M	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	ko00000,ko00001,ko01000,ko01003,ko02000	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
APPLDMEG_00937	8.97e-219	-	-	-	M	-	-	-	COG0463, glycosyltransferases involved in cell wall biogenesis
APPLDMEG_00938	3.6e-218	-	-	-	T	-	-	-	Diguanylate cyclase
APPLDMEG_00939	1.18e-45	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
APPLDMEG_00940	1.37e-76	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	transcriptional
APPLDMEG_00941	3.66e-35	-	-	-	L	-	-	-	Transposase
APPLDMEG_00942	1.46e-57	-	-	-	-	-	-	-	-
APPLDMEG_00943	0.0	ctpE	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
APPLDMEG_00944	2.28e-77	-	-	-	-	-	-	-	-
APPLDMEG_00945	5.94e-53	MA20_20425	2.5.1.19, 4.2.1.10, 4.2.99.21, 5.4.99.5	-	E	ko:K00800,ko:K03785,ko:K04092,ko:K04782	ko00400,ko01053,ko01100,ko01110,ko01130,ko01230,map00400,map01053,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase
APPLDMEG_00946	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APPLDMEG_00947	4.1e-135	trpG	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	anthranilate
APPLDMEG_00948	4.99e-227	trpD	2.4.2.18, 4.1.3.27	-	F	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APPLDMEG_00949	5.59e-173	trpC	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
APPLDMEG_00950	1.53e-128	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the TrpF family
APPLDMEG_00951	6.77e-289	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
APPLDMEG_00952	3.39e-181	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
APPLDMEG_00954	5.59e-223	-	-	-	EGP	ko:K08218	ko01501,map01501	ko00000,ko00001,ko00002,ko02000	Major facilitator Superfamily
APPLDMEG_00955	6.08e-97	copY	-	-	K	-	-	-	negative regulation of transcription, DNA-templated
APPLDMEG_00956	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
APPLDMEG_00957	2.72e-42	copZ	-	-	P	-	-	-	Heavy metal-associated domain protein
APPLDMEG_00958	3.37e-44	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
APPLDMEG_00959	9.31e-107	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
APPLDMEG_00960	2.29e-67	-	-	-	-	-	-	-	-
APPLDMEG_00961	6.63e-247	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
APPLDMEG_00962	2.02e-147	glnP9	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00963	3.24e-148	glnP7	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_00964	1.27e-172	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_00965	1.1e-198	cjaA	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
APPLDMEG_00969	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
APPLDMEG_00970	1.5e-151	ywaF	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
APPLDMEG_00971	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APPLDMEG_00972	9.57e-252	yjbB	-	-	G	-	-	-	Permeases of the major facilitator superfamily
APPLDMEG_00973	2.06e-200	rgg	-	-	K	-	-	-	Transcriptional activator, Rgg GadR MutR family
APPLDMEG_00974	1.41e-123	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter
APPLDMEG_00975	4.34e-82	yjqA	-	-	S	-	-	-	Bacterial PH domain
APPLDMEG_00976	1.5e-200	corA	-	-	P	-	-	-	CorA-like protein
APPLDMEG_00977	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
APPLDMEG_00978	2.9e-56	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
APPLDMEG_00979	1.75e-180	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase
APPLDMEG_00980	3.87e-204	nodB3	-	-	G	-	-	-	deacetylase
APPLDMEG_00981	8.74e-184	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
APPLDMEG_00982	4.46e-126	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
APPLDMEG_00983	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
APPLDMEG_00984	7.08e-291	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APPLDMEG_00985	8.01e-125	XK27_07830	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase GNAT Family
APPLDMEG_00986	7.45e-296	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
APPLDMEG_00987	4.94e-212	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
APPLDMEG_00988	2.48e-205	rbn	-	-	E	ko:K07058	-	ko00000	Belongs to the UPF0761 family
APPLDMEG_00989	3.45e-111	ccl	-	-	S	-	-	-	cog cog4708
APPLDMEG_00990	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APPLDMEG_00991	4.32e-234	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
APPLDMEG_00993	1.44e-228	yfjR	-	-	K	-	-	-	regulation of single-species biofilm formation
APPLDMEG_00995	1.7e-88	-	-	-	S	-	-	-	QueT transporter
APPLDMEG_00996	1.41e-201	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
APPLDMEG_00998	2.79e-80	XK27_00915	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APPLDMEG_00999	1.99e-15	yjdB	-	-	S	-	-	-	Domain of unknown function (DUF4767)
APPLDMEG_01000	9.6e-213	tehB	2.1.1.265	-	PQ	ko:K16868	-	ko00000,ko01000	tellurite resistance protein tehb
APPLDMEG_01001	1.16e-228	-	-	-	O	-	-	-	protein import
APPLDMEG_01002	1.93e-159	agrA	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
APPLDMEG_01003	2.65e-268	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_01005	1.87e-57	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
APPLDMEG_01006	3.71e-49	ylqC	-	-	L	ko:K06960	-	ko00000	Belongs to the UPF0109 family
APPLDMEG_01007	2.81e-297	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
APPLDMEG_01008	0.0	ydaO	-	-	E	-	-	-	amino acid
APPLDMEG_01009	4.02e-129	folE	3.5.4.16	-	F	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	gtp cyclohydrolase
APPLDMEG_01010	8.69e-187	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APPLDMEG_01011	0.0	amy	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
APPLDMEG_01012	4.82e-78	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APPLDMEG_01013	3.5e-101	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APPLDMEG_01014	1.04e-211	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
APPLDMEG_01015	7.62e-270	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
APPLDMEG_01016	4.03e-179	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type spermidine putrescine transport system, permease component I
APPLDMEG_01017	3.07e-167	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type spermidine putrescine transport system, permease component II
APPLDMEG_01018	5.26e-260	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	spermidine putrescine ABC transporter
APPLDMEG_01019	4.79e-196	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	HflC and HflK could regulate a protease
APPLDMEG_01020	2.36e-93	gloA	4.4.1.5	-	E	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Lactoylglutathione lyase
APPLDMEG_01021	7.64e-197	-	-	-	GK	-	-	-	ROK family
APPLDMEG_01022	4.21e-266	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APPLDMEG_01023	1.49e-131	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
APPLDMEG_01024	1.19e-277	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APPLDMEG_01025	3.28e-93	ogt	2.1.1.63, 3.2.2.20	-	L	ko:K00567,ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	methylated-DNA-[protein]-cysteine S-methyltransferase activity
APPLDMEG_01026	1.19e-77	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
APPLDMEG_01028	9.16e-74	lrgA	-	-	S	ko:K06518	-	ko00000,ko02000	Effector of murein hydrolase LrgA
APPLDMEG_01029	2.65e-150	lrgB	-	-	M	-	-	-	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
APPLDMEG_01030	6.68e-136	-	-	-	S	-	-	-	IA, variant 1
APPLDMEG_01031	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APPLDMEG_01032	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APPLDMEG_01033	1.33e-142	serB	3.1.3.3	-	E	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01009	phosphoserine phosphatase
APPLDMEG_01034	0.0	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APPLDMEG_01035	6.71e-207	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPLDMEG_01036	1.63e-70	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPLDMEG_01037	1.77e-133	csn2	-	-	S	ko:K19137	-	ko00000,ko02048	CRISPR-associated protein (Cas_Csn2)
APPLDMEG_01039	3.77e-113	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	DNA-templated transcription, initiation
APPLDMEG_01040	8.87e-174	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
APPLDMEG_01041	3e-291	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
APPLDMEG_01042	1.24e-101	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
APPLDMEG_01043	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
APPLDMEG_01044	1.76e-109	XK27_03960	-	-	S	-	-	-	Protein of unknown function (DUF3013)
APPLDMEG_01045	3.01e-102	-	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
APPLDMEG_01046	2.63e-75	XK27_02675	-	-	K	-	-	-	Acetyltransferase GNAT Family
APPLDMEG_01047	2.12e-224	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
APPLDMEG_01048	5.61e-169	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
APPLDMEG_01049	0.0	cpdB	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
APPLDMEG_01050	3.5e-108	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
APPLDMEG_01051	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APPLDMEG_01052	3.91e-95	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
APPLDMEG_01053	0.0	dex	3.2.1.11	GH66	G	ko:K05988	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 66
APPLDMEG_01054	5.5e-302	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APPLDMEG_01055	5.97e-145	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
APPLDMEG_01056	3.84e-145	-	-	-	K	-	-	-	Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
APPLDMEG_01057	3.14e-242	XK27_00055	-	-	P	-	-	-	Major Facilitator
APPLDMEG_01058	3.52e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APPLDMEG_01059	3.89e-316	-	-	-	D	-	-	-	nuclear chromosome segregation
APPLDMEG_01060	4.26e-168	glnQ	-	-	E	ko:K17076	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_01061	0.0	XK27_05795	-	-	P	ko:K17073,ko:K17074	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
APPLDMEG_01062	1.44e-194	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
APPLDMEG_01064	3.47e-164	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
APPLDMEG_01065	3.65e-241	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	transferase
APPLDMEG_01066	1.65e-176	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	ABC-type transport system involved in Fe-S cluster assembly, ATPase component
APPLDMEG_01067	1.98e-297	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
APPLDMEG_01068	1.23e-295	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APPLDMEG_01069	7.11e-96	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
APPLDMEG_01070	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
APPLDMEG_01071	6.12e-35	-	-	-	-	-	-	-	-
APPLDMEG_01072	7.78e-201	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APPLDMEG_01073	2.41e-233	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APPLDMEG_01074	7.14e-92	adcR	-	-	K	-	-	-	transcriptional
APPLDMEG_01075	3.43e-173	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_01076	1.22e-163	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_01077	1.81e-202	mleP2	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
APPLDMEG_01078	0.0	ptsG	2.7.1.208	-	G	ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01079	1.79e-196	rgfB	3.1.3.90	-	L	ko:K06896	ko00500,map00500	ko00000,ko00001,ko01000	Endonuclease/Exonuclease/phosphatase family
APPLDMEG_01080	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
APPLDMEG_01081	4.62e-182	sorD	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
APPLDMEG_01082	0.0	srlM	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
APPLDMEG_01083	2.45e-109	gutM	-	-	K	ko:K02466	-	ko00000	phosphoenolpyruvate-dependent sugar phosphotransferase system
APPLDMEG_01084	6.32e-124	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system glucitol sorbitol-specific
APPLDMEG_01085	4.63e-228	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS sorbitol transporter subunit IIB
APPLDMEG_01086	2.58e-77	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	sorbitol-specific, IIA component
APPLDMEG_01087	7.78e-21	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
APPLDMEG_01088	2.58e-77	B4168_4126	-	-	L	ko:K07493	-	ko00000	MULE transposase domain
APPLDMEG_01089	6.62e-138	-	-	-	L	-	-	-	Transposase IS116 IS110 IS902
APPLDMEG_01090	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
APPLDMEG_01091	1.4e-280	-	-	-	L	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_01092	8.7e-199	Z012_04635	-	-	K	ko:K20373	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_01093	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter
APPLDMEG_01094	2.37e-161	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
APPLDMEG_01095	1.48e-62	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	protein transport
APPLDMEG_01096	3.56e-182	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APPLDMEG_01097	7.14e-185	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
APPLDMEG_01098	3.01e-292	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
APPLDMEG_01099	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
APPLDMEG_01100	0.0	XK27_00665	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter
APPLDMEG_01101	1.74e-182	cmpC	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_01102	7.72e-57	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APPLDMEG_01103	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
APPLDMEG_01105	4.19e-60	-	-	-	-	-	-	-	-
APPLDMEG_01106	5.41e-73	WQ51_06355	-	-	S	-	-	-	TM2 domain
APPLDMEG_01107	6.71e-207	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
APPLDMEG_01108	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
APPLDMEG_01109	2.73e-28	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
APPLDMEG_01110	1.05e-33	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Belongs to the SecE SEC61-gamma family
APPLDMEG_01111	2.8e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
APPLDMEG_01112	7.78e-93	-	3.1.3.27, 3.1.3.4, 3.1.3.81, 3.6.1.27	-	I	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	ko00000,ko00001,ko01000,ko01011	phosphatidate phosphatase activity
APPLDMEG_01113	1.23e-183	cof	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
APPLDMEG_01114	1.79e-169	-	-	-	K	ko:K22103	-	ko00000,ko03000	transcriptional regulator (DeoR family)
APPLDMEG_01115	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
APPLDMEG_01116	4.52e-96	napB	-	-	K	-	-	-	transcriptional
APPLDMEG_01117	7.2e-281	-	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
APPLDMEG_01118	3.04e-198	cylA	-	-	V	ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_01119	3.72e-179	cylB	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
APPLDMEG_01120	1.92e-97	-	-	-	K	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
APPLDMEG_01121	3.15e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
APPLDMEG_01122	5.36e-157	mta	-	-	K	ko:K21743	-	ko00000,ko03000	Transcriptional
APPLDMEG_01123	1.82e-155	-	-	-	V	-	-	-	abc transporter atp-binding protein
APPLDMEG_01124	1.93e-262	-	-	-	V	-	-	-	FtsX-like permease family
APPLDMEG_01125	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APPLDMEG_01126	8.04e-191	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
APPLDMEG_01127	9.21e-94	yhaH	-	-	S	-	-	-	Protein of unknown function (DUF805)
APPLDMEG_01128	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
APPLDMEG_01129	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
APPLDMEG_01130	1.72e-141	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
APPLDMEG_01131	3.45e-121	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
APPLDMEG_01132	1.89e-64	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
APPLDMEG_01133	5.28e-284	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
APPLDMEG_01134	0.0	mapZ	-	-	D	ko:K20073	-	ko00000	Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning
APPLDMEG_01135	0.0	snf	-	-	L	-	-	-	Superfamily II DNA RNA helicases, SNF2 family'
APPLDMEG_01136	9.47e-28	XK27_11680	-	-	-	-	-	-	-
APPLDMEG_01137	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
APPLDMEG_01138	6.77e-111	-	-	-	K	-	-	-	histone acetyltransferase HPA2 and related acetyltransferases
APPLDMEG_01139	0.0	mltG	-	-	ADL	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APPLDMEG_01140	4.77e-100	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
APPLDMEG_01141	3.44e-208	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APPLDMEG_01142	7.55e-58	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
APPLDMEG_01143	2.1e-163	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APPLDMEG_01144	2.55e-121	XK27_09705	-	-	S	ko:K06950	-	ko00000	HD superfamily hydrolase
APPLDMEG_01145	2e-144	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
APPLDMEG_01147	4.75e-309	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
APPLDMEG_01148	3.65e-116	-	-	-	K	-	-	-	transcriptional regulator
APPLDMEG_01149	1.62e-48	-	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
APPLDMEG_01150	8.38e-192	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
APPLDMEG_01151	5.88e-230	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APPLDMEG_01152	1.2e-122	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
APPLDMEG_01153	1.23e-111	ykuL	-	-	S	-	-	-	CBS domain
APPLDMEG_01154	2.63e-162	xerD	-	-	L	-	-	-	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site
APPLDMEG_01155	3.91e-155	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APPLDMEG_01156	4.02e-124	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APPLDMEG_01157	1.23e-169	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
APPLDMEG_01158	2.38e-52	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
APPLDMEG_01159	0.0	trkH	-	-	P	ko:K03498	-	ko00000,ko02000	Cation transport protein
APPLDMEG_01160	1.82e-310	trkA	-	-	P	ko:K03499	-	ko00000,ko02000	Potassium transporter peripheral membrane component
APPLDMEG_01161	6.48e-125	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
APPLDMEG_01162	2.29e-116	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APPLDMEG_01163	2.14e-128	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Membrane-associated phospholipid phosphatase
APPLDMEG_01164	7.41e-200	-	-	-	K	ko:K20342,ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_01165	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K20344	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
APPLDMEG_01166	2.12e-70	yhaI	-	-	L	-	-	-	Membrane
APPLDMEG_01167	3.34e-304	-	-	-	S	-	-	-	Domain of unknown function (DUF4173)
APPLDMEG_01168	1.25e-123	ureI	-	-	S	ko:K03191	ko05120,map05120	ko00000,ko00001,ko02000	AmiS/UreI family transporter
APPLDMEG_01169	1.02e-61	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease gamma subunit family
APPLDMEG_01170	7.63e-72	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease beta subunit family
APPLDMEG_01171	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
APPLDMEG_01172	2.74e-101	ureE	-	-	O	ko:K03187	-	ko00000	enzyme active site formation
APPLDMEG_01173	5.02e-167	ureF	-	-	O	ko:K03188	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APPLDMEG_01174	4.71e-142	ureG	-	-	KO	ko:K03189	-	ko00000	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APPLDMEG_01175	3.32e-202	ureD	-	-	O	ko:K03190	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
APPLDMEG_01176	4.11e-226	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PDGLE domain
APPLDMEG_01177	5.36e-173	nikQ	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport protein
APPLDMEG_01178	1.82e-165	-	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
APPLDMEG_01179	9.97e-185	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
APPLDMEG_01180	2e-209	metQ	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
APPLDMEG_01181	0.0	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases
APPLDMEG_01182	1.1e-236	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APPLDMEG_01183	1.27e-152	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_01184	6.96e-266	sstT	-	-	E	ko:K07862	-	ko00000,ko02000	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APPLDMEG_01185	1.2e-201	ilvH	-	-	S	-	-	-	S-adenosyl-l-methionine hydroxide adenosyltransferase
APPLDMEG_01186	8.98e-122	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
APPLDMEG_01187	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_01188	2.79e-188	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
APPLDMEG_01189	2.13e-152	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
APPLDMEG_01190	3.9e-298	ktrB	-	-	P	ko:K03498	-	ko00000,ko02000	COG0168 Trk-type K transport systems, membrane components
APPLDMEG_01191	6.57e-163	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Ribosomal RNA small subunit methyltransferase G
APPLDMEG_01192	7.7e-117	ylbN	-	-	K	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
APPLDMEG_01193	1.62e-159	csrR	-	-	T	-	-	-	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
APPLDMEG_01194	0.0	covS	-	-	T	-	-	-	Histidine kinase
APPLDMEG_01195	5.84e-105	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APPLDMEG_01196	3.77e-269	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Replication initiation and membrane attachment
APPLDMEG_01197	2.54e-212	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
APPLDMEG_01198	4.15e-314	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
APPLDMEG_01199	1.69e-142	-	-	-	-	-	-	-	-
APPLDMEG_01200	3.4e-298	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APPLDMEG_01201	7.55e-82	manO	-	-	S	-	-	-	protein conserved in bacteria
APPLDMEG_01202	6.74e-214	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose fructose sorbose family IID component
APPLDMEG_01203	4.59e-164	manM	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	pts system
APPLDMEG_01204	1.39e-231	manL	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01205	4.66e-87	manO	-	-	S	-	-	-	Protein conserved in bacteria
APPLDMEG_01206	3.97e-202	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose fructose sorbose family IID component
APPLDMEG_01207	2.07e-169	manY	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	pts system
APPLDMEG_01208	7.02e-223	manX	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01209	2.93e-178	XK27_00940	3.5.1.9	-	S	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	ko00000,ko00001,ko00002,ko01000	Metal-dependent hydrolase
APPLDMEG_01210	1.03e-196	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
APPLDMEG_01211	7.03e-316	XK27_07275	-	-	S	ko:K06901	-	ko00000,ko02000	permease
APPLDMEG_01212	7.31e-100	ydiB	-	-	M	ko:K06925	-	ko00000,ko03016	ATPase or kinase
APPLDMEG_01213	5.67e-112	XK27_05885	2.3.1.82	-	M	ko:K18816	-	br01600,ko00000,ko01000,ko01504	phosphinothricin N-acetyltransferase activity
APPLDMEG_01214	5.47e-266	brpA	-	-	K	-	-	-	Transcriptional
APPLDMEG_01215	1.01e-104	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
APPLDMEG_01216	6.52e-257	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
APPLDMEG_01217	9.2e-64	ylxR	-	-	K	ko:K07742	-	ko00000	Nucleic-acid-binding protein implicated in transcription termination
APPLDMEG_01218	1.66e-56	ylxQ	-	-	J	-	-	-	ribosomal protein
APPLDMEG_01219	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APPLDMEG_01220	5.68e-76	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APPLDMEG_01221	1.13e-127	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
APPLDMEG_01222	3.09e-237	femA	2.3.2.17	-	V	ko:K11694	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	protein involved in methicillin resistance
APPLDMEG_01223	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APPLDMEG_01224	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
APPLDMEG_01225	0.0	pacL	-	-	P	-	-	-	cation transport ATPase
APPLDMEG_01226	3.41e-256	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
APPLDMEG_01227	2.73e-285	malY	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
APPLDMEG_01228	0.0	-	-	-	L	-	-	-	Transposase
APPLDMEG_01229	0.0	-	3.2.1.26, 3.2.1.65	GH32	G	ko:K01193,ko:K01212	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
APPLDMEG_01230	0.0	sacB	2.4.1.10, 2.4.1.9	GH68	G	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	Belongs to the glycosyl hydrolase 68 family
APPLDMEG_01231	1.06e-145	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APPLDMEG_01232	3.75e-135	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
APPLDMEG_01233	6.19e-93	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
APPLDMEG_01234	4.33e-62	ylbG	-	-	S	-	-	-	UPF0298 protein
APPLDMEG_01235	5.67e-267	livJ	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
APPLDMEG_01236	9.55e-189	livH	-	-	E	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
APPLDMEG_01237	1.64e-184	livM	-	-	E	ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
APPLDMEG_01238	5.4e-175	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
APPLDMEG_01239	4.6e-158	livF	-	-	E	ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
APPLDMEG_01240	4.25e-141	XK27_04065	-	-	S	ko:K04767	-	ko00000	CBS domain
APPLDMEG_01241	2.34e-212	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
APPLDMEG_01242	1.51e-140	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
APPLDMEG_01243	2.1e-304	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APPLDMEG_01244	8.3e-128	comFC	-	-	K	ko:K02242	-	ko00000,ko00002,ko02044	competence protein
APPLDMEG_01245	4.11e-123	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APPLDMEG_01246	1.92e-286	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
APPLDMEG_01247	4.62e-20	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L34
APPLDMEG_01248	9.27e-127	-	1.6.5.2	-	S	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	ko00000,ko00001,ko01000	NADPH-quinone reductase (modulator of drug activity B)
APPLDMEG_01249	1.6e-127	-	-	-	K	-	-	-	Transcriptional regulator
APPLDMEG_01250	2.52e-199	jag	-	-	S	ko:K06346	-	ko00000	RNA-binding protein
APPLDMEG_01251	4.24e-187	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APPLDMEG_01252	9.69e-72	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
APPLDMEG_01253	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Argininosuccinate lyase
APPLDMEG_01254	2.89e-293	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
APPLDMEG_01255	7.64e-167	fasA	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Response regulator of the LytR AlgR family
APPLDMEG_01256	2.95e-285	fasC	-	-	T	-	-	-	protein histidine kinase activity
APPLDMEG_01257	1.49e-263	hpk9	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_01258	2.1e-193	hpk9	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
APPLDMEG_01259	1.38e-291	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	signal transduction protein with a C-terminal ATPase domain
APPLDMEG_01260	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APPLDMEG_01261	0.0	amiA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
APPLDMEG_01262	2.76e-155	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
APPLDMEG_01263	1.69e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APPLDMEG_01264	4.66e-66	-	-	-	S	-	-	-	Protein of unknown function (DUF3397)
APPLDMEG_01265	7.91e-115	cah	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
APPLDMEG_01266	2.05e-163	-	-	-	S	-	-	-	Mitochondrial biogenesis AIM24
APPLDMEG_01267	2.63e-285	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APPLDMEG_01268	6.09e-96	-	3.5.1.19	-	Q	ko:K08281	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
APPLDMEG_01269	5.55e-100	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
APPLDMEG_01270	3.33e-140	XK27_09620	-	-	S	-	-	-	FMN reductase (NADPH) activity
APPLDMEG_01271	3.61e-307	XK27_09615	-	-	C	ko:K19784	-	ko00000	reductase
APPLDMEG_01272	1.05e-181	nirC_1	-	-	P	-	-	-	Formate nitrite transporter
APPLDMEG_01273	5.12e-124	XK27_08585	-	-	S	ko:K16926	-	ko00000,ko00002,ko02000	Psort location CytoplasmicMembrane, score
APPLDMEG_01274	4.68e-233	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
APPLDMEG_01275	5.35e-216	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
APPLDMEG_01276	3.65e-149	gluP	3.4.21.105	-	O	ko:K19225	-	ko00000,ko01000,ko01002	membrane protein (homolog of Drosophila rhomboid)
APPLDMEG_01277	2.32e-121	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APPLDMEG_01278	2.22e-279	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
APPLDMEG_01279	3.08e-109	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
APPLDMEG_01280	3.22e-165	-	-	-	S	ko:K07025	-	ko00000	HAD hydrolase, family IA, variant
APPLDMEG_01281	1.58e-200	rrmA	2.1.1.187	-	Q	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	methyltransferase
APPLDMEG_01285	1.99e-116	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
APPLDMEG_01286	4.45e-86	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APPLDMEG_01287	3.2e-49	yeeD	-	-	O	ko:K07112	-	ko00000	sulfur carrier activity
APPLDMEG_01288	1.16e-241	yeeE	-	-	S	ko:K07112	-	ko00000	Sulphur transport
APPLDMEG_01289	2.62e-145	XK27_10290	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
APPLDMEG_01291	4.76e-71	ytpP	-	-	CO	-	-	-	Thioredoxin
APPLDMEG_01293	7.17e-258	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
APPLDMEG_01294	2.36e-170	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APPLDMEG_01295	5.02e-129	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family protein
APPLDMEG_01297	6.98e-135	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
APPLDMEG_01298	1.05e-36	lanR	-	-	K	ko:K07729	-	ko00000,ko03000	sequence-specific DNA binding
APPLDMEG_01299	2.84e-283	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APPLDMEG_01300	9.71e-226	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
APPLDMEG_01301	3.67e-17	-	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Putative Competence protein ComGF
APPLDMEG_01302	2.66e-92	comGF	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Competence protein ComGF
APPLDMEG_01303	1.23e-21	-	-	-	NU	-	-	-	Type II secretory pathway pseudopilin
APPLDMEG_01304	8.54e-89	cglD	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	Competence protein
APPLDMEG_01305	1.1e-62	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
APPLDMEG_01306	7.39e-179	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APPLDMEG_01307	3.13e-224	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APPLDMEG_01308	1.37e-91	-	-	-	S	-	-	-	cog cog4699
APPLDMEG_01309	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPLDMEG_01310	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPLDMEG_01311	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
APPLDMEG_01312	1.65e-304	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APPLDMEG_01313	2.56e-248	ilvC	1.1.1.86	-	H	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APPLDMEG_01314	7.09e-101	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
APPLDMEG_01315	0.0	ilvB	2.2.1.6	-	EH	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
APPLDMEG_01316	0.0	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
APPLDMEG_01320	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
APPLDMEG_01321	1.87e-76	asp	-	-	S	-	-	-	cog cog1302
APPLDMEG_01322	1.11e-282	norN	-	-	V	-	-	-	Mate efflux family protein
APPLDMEG_01323	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
APPLDMEG_01324	6.92e-05	yebC	-	-	M	-	-	-	Membrane
APPLDMEG_01326	0.0	adh	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
APPLDMEG_01327	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
APPLDMEG_01328	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
APPLDMEG_01329	1.37e-123	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
APPLDMEG_01332	8.52e-212	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	aldolase
APPLDMEG_01334	2.26e-304	-	-	-	H	-	-	-	gamma-glutamylcysteine synthetase
APPLDMEG_01335	3.03e-83	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein l17
APPLDMEG_01336	1.8e-218	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APPLDMEG_01337	1.63e-82	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APPLDMEG_01338	4.42e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APPLDMEG_01339	3.26e-22	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
APPLDMEG_01340	6.91e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APPLDMEG_01341	1.02e-149	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
APPLDMEG_01342	8.65e-293	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
APPLDMEG_01343	8.47e-85	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
APPLDMEG_01344	9.89e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	ribosomal protein l30
APPLDMEG_01345	7e-104	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APPLDMEG_01346	7.15e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APPLDMEG_01347	5.88e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APPLDMEG_01348	3.78e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APPLDMEG_01349	2.03e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APPLDMEG_01350	5.86e-122	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APPLDMEG_01351	5.67e-64	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APPLDMEG_01352	2.55e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APPLDMEG_01353	3.08e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APPLDMEG_01354	6.2e-35	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
APPLDMEG_01355	4.35e-94	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APPLDMEG_01356	9.44e-153	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APPLDMEG_01357	1.21e-71	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APPLDMEG_01358	8.13e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APPLDMEG_01359	5.06e-196	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APPLDMEG_01360	6e-60	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
APPLDMEG_01361	2.13e-135	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
APPLDMEG_01362	3.17e-142	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APPLDMEG_01363	4.29e-64	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
APPLDMEG_01364	8.46e-239	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
APPLDMEG_01365	0.0	XK27_09800	-	-	I	-	-	-	Acyltransferase
APPLDMEG_01366	1.21e-47	-	-	-	S	-	-	-	MORN repeat protein
APPLDMEG_01367	1.55e-104	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APPLDMEG_01368	1.55e-315	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APPLDMEG_01369	8.8e-116	flaR	-	-	F	-	-	-	topology modulation protein
APPLDMEG_01370	2.6e-107	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
APPLDMEG_01371	1.46e-117	-	-	-	K	-	-	-	sequence-specific DNA binding
APPLDMEG_01372	2.78e-208	-	-	-	L	-	-	-	Replication initiation factor
APPLDMEG_01373	1.95e-26	-	-	-	S	-	-	-	Domain of unknown function (DUF3173)
APPLDMEG_01374	7.98e-274	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
APPLDMEG_01376	5.09e-301	rarA	-	-	L	ko:K07478	-	ko00000	ATPase related to the helicase subunit of the Holliday junction resolvase
APPLDMEG_01377	1.73e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
APPLDMEG_01378	9.75e-59	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
APPLDMEG_01379	9.82e-92	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APPLDMEG_01380	1.34e-62	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
APPLDMEG_01381	0.0	-	-	-	S	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_01382	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
APPLDMEG_01383	7.68e-20	-	-	-	-	-	-	-	-
APPLDMEG_01384	7.87e-111	-	-	-	K	-	-	-	acetyltransferase
APPLDMEG_01385	9.96e-147	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APPLDMEG_01386	1.09e-154	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
APPLDMEG_01387	1.03e-213	XK27_01785	-	-	S	-	-	-	cog cog1284
APPLDMEG_01388	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
APPLDMEG_01390	8.85e-304	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
APPLDMEG_01391	1.3e-119	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01392	9.49e-52	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01394	6.09e-278	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
APPLDMEG_01395	3.57e-35	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
APPLDMEG_01396	1.22e-26	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
APPLDMEG_01401	2.96e-135	XK27_06885	-	-	L	-	-	-	hydrolase
APPLDMEG_01402	4.5e-71	XK27_06915	-	-	K	ko:K10947	-	ko00000,ko03000	transcriptional regulator, PadR family
APPLDMEG_01403	8.54e-99	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
APPLDMEG_01404	7.24e-145	-	-	-	S	-	-	-	Putative adhesin
APPLDMEG_01405	7.55e-262	XK27_06930	-	-	V	ko:K01421	-	ko00000	domain protein
APPLDMEG_01406	1.33e-122	XK27_06935	-	-	K	-	-	-	transcriptional regulator
APPLDMEG_01407	2.56e-69	XK27_04840	-	-	M	ko:K08987	-	ko00000	Membrane
APPLDMEG_01408	5.32e-13	-	-	-	-	-	-	-	-
APPLDMEG_01409	1.25e-141	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APPLDMEG_01410	6.16e-63	WQ51_01655	-	-	S	-	-	-	Biofilm formation stimulator VEG
APPLDMEG_01411	1.1e-313	dnaC	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
APPLDMEG_01412	1.77e-98	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
APPLDMEG_01413	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
APPLDMEG_01414	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
APPLDMEG_01415	1.23e-128	yvbG	-	-	U	ko:K05595	-	ko00000,ko02000	UPF0056 membrane protein
APPLDMEG_01416	1.09e-277	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
APPLDMEG_01417	0.0	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
APPLDMEG_01418	9.7e-126	isaA	-	-	M	-	-	-	Immunodominant staphylococcal antigen A
APPLDMEG_01419	4.51e-105	lytE	-	-	M	-	-	-	LysM domain protein
APPLDMEG_01420	2.63e-171	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPLDMEG_01421	2.39e-191	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPLDMEG_01422	1.75e-191	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APPLDMEG_01423	1.09e-117	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APPLDMEG_01424	1.85e-163	-	-	-	S	ko:K15539	-	ko00000	sequence-specific DNA binding
APPLDMEG_01425	3.57e-298	ymfH	-	-	S	-	-	-	Peptidase M16
APPLDMEG_01426	3.13e-292	albE	-	-	S	-	-	-	Peptidase M16
APPLDMEG_01427	5.94e-75	yaaA	-	-	S	-	-	-	S4 domain protein YaaA
APPLDMEG_01428	1.09e-253	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APPLDMEG_01429	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
APPLDMEG_01430	6.2e-240	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
APPLDMEG_01431	5.39e-193	XK27_10395	-	-	S	-	-	-	membrane
APPLDMEG_01432	0.0	ykpA	-	-	S	-	-	-	abc transporter atp-binding protein
APPLDMEG_01433	0.0	XK27_10405	-	-	S	-	-	-	Bacterial membrane protein YfhO
APPLDMEG_01437	1.5e-151	yoaK	-	-	S	-	-	-	Protein of unknown function (DUF1275)
APPLDMEG_01438	1.96e-103	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APPLDMEG_01439	5.83e-274	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain'
APPLDMEG_01440	6.53e-172	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
APPLDMEG_01441	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APPLDMEG_01442	1.6e-252	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
APPLDMEG_01443	8.11e-40	yyzM	-	-	S	-	-	-	Protein conserved in bacteria
APPLDMEG_01444	7.47e-259	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
APPLDMEG_01445	5.18e-134	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
APPLDMEG_01446	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APPLDMEG_01447	1.87e-53	yabO	-	-	J	-	-	-	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
APPLDMEG_01448	1.12e-78	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
APPLDMEG_01449	1.36e-05	-	-	-	-	-	-	-	-
APPLDMEG_01450	6.14e-297	-	3.5.2.6	-	V	ko:K01467	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01000	Beta-lactamase enzyme family
APPLDMEG_01451	8.93e-290	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
APPLDMEG_01452	5.23e-125	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
APPLDMEG_01453	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APPLDMEG_01454	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
APPLDMEG_01455	1.92e-238	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
APPLDMEG_01456	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
APPLDMEG_01457	6.51e-145	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APPLDMEG_01458	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APPLDMEG_01459	5.29e-239	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
APPLDMEG_01460	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APPLDMEG_01461	4.63e-69	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APPLDMEG_01462	4.64e-92	-	-	-	S	ko:K06893	-	ko00000	SnoaL-like polyketide cyclase
APPLDMEG_01463	3.98e-70	hxlR	-	-	K	-	-	-	HxlR-like helix-turn-helix
APPLDMEG_01464	2.15e-169	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APPLDMEG_01465	2.05e-228	pyrD	1.3.5.2, 1.3.98.1	-	F	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dihydroorotate to orotate
APPLDMEG_01467	3.1e-52	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
APPLDMEG_01468	9.19e-124	ypmS	-	-	S	-	-	-	Protein conserved in bacteria
APPLDMEG_01469	1.63e-199	XK27_03630	-	-	E	-	-	-	COG2755 Lysophospholipase L1 and related esterases
APPLDMEG_01470	1.04e-185	WQ51_01275	-	-	S	-	-	-	DegV family
APPLDMEG_01471	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
APPLDMEG_01472	1.26e-96	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
APPLDMEG_01473	1.56e-189	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
APPLDMEG_01474	1.51e-199	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
APPLDMEG_01475	2.44e-40	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APPLDMEG_01476	3.51e-294	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
APPLDMEG_01478	1.84e-153	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APPLDMEG_01479	3.15e-163	dnaD	-	-	-	ko:K02086	-	ko00000	-
APPLDMEG_01480	1.63e-231	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APPLDMEG_01481	7.52e-121	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APPLDMEG_01482	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease recj
APPLDMEG_01483	4.22e-86	GnaT	2.5.1.16	-	K	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferase
APPLDMEG_01484	8.01e-25	-	-	-	Q	-	-	-	Methyltransferase domain
APPLDMEG_01485	1.74e-176	yqjQ	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
APPLDMEG_01486	1.81e-221	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
APPLDMEG_01487	5.05e-146	XK27_05445	-	-	G	-	-	-	UDPglucose--hexose-1-phosphate uridylyltransferase
APPLDMEG_01488	4.52e-285	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APPLDMEG_01489	2.12e-297	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
APPLDMEG_01490	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_01491	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_01492	0.0	-	2.4.1.5	GH13	M	ko:K00689	ko00500,ko02020,map00500,map02020	ko00000,ko00001,ko01000	KxYKxGKxW signal domain protein
APPLDMEG_01493	1.01e-229	-	-	-	M	-	-	-	glycosyl transferase family 2
APPLDMEG_01494	3.62e-160	-	-	-	S	-	-	-	Carbohydrate-binding domain-containing protein Cthe_2159
APPLDMEG_01495	4.85e-185	-	-	-	P	-	-	-	molecular chaperone
APPLDMEG_01496	3.25e-133	XK27_05505	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
APPLDMEG_01498	1.27e-66	hisE	3.5.4.19, 3.6.1.31, 5.3.1.16	-	E	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosyl-ATP diphosphatase activity
APPLDMEG_01499	2.36e-77	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APPLDMEG_01500	1.61e-175	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
APPLDMEG_01501	9.32e-164	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APPLDMEG_01502	1.35e-140	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APPLDMEG_01503	1.17e-137	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
APPLDMEG_01504	3.57e-299	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APPLDMEG_01505	3.42e-150	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
APPLDMEG_01506	8.36e-231	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APPLDMEG_01507	3.09e-245	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APPLDMEG_01508	1.44e-77	XK27_08085	-	-	-	-	-	-	-
APPLDMEG_01509	2.77e-199	XK27_08080	-	-	G	-	-	-	Exopolysaccharide biosynthesis protein
APPLDMEG_01510	5.88e-175	hisJ	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphatase and related hydrolases of the PHP family
APPLDMEG_01511	1.98e-148	-	-	-	S	-	-	-	tigr01906
APPLDMEG_01512	6.34e-180	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
APPLDMEG_01513	4.33e-182	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
APPLDMEG_01514	1.49e-273	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
APPLDMEG_01517	3.86e-263	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
APPLDMEG_01518	2.36e-143	rmlC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
APPLDMEG_01519	7.83e-206	rfbA	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APPLDMEG_01520	0.0	-	-	-	S	-	-	-	phospholipase Carboxylesterase
APPLDMEG_01521	1.38e-254	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	oxidoreductase
APPLDMEG_01522	2.97e-183	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	Mediates zinc uptake. May also transport other divalent cations
APPLDMEG_01523	2.39e-182	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APPLDMEG_01524	2.79e-155	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
APPLDMEG_01525	5.03e-84	mesH	-	-	S	-	-	-	GtrA-like protein
APPLDMEG_01526	9.24e-317	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APPLDMEG_01527	3.03e-210	ybbR	-	-	S	-	-	-	Protein conserved in bacteria
APPLDMEG_01528	1.6e-189	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APPLDMEG_01529	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Mur ligase, middle domain protein
APPLDMEG_01530	1.63e-189	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
APPLDMEG_01531	0.0	mprF	2.3.2.3	-	J	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APPLDMEG_01532	2.59e-170	-	1.11.1.10	-	S	ko:K00433	-	ko00000,ko01000	Alpha beta hydrolase
APPLDMEG_01533	7.55e-53	-	-	-	S	-	-	-	yiaA/B two helix domain
APPLDMEG_01534	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	abc transporter atp-binding protein
APPLDMEG_01535	1.51e-146	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
APPLDMEG_01536	3.41e-238	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
APPLDMEG_01537	2e-287	XK27_05680	-	-	M	-	-	-	carbamoylphosphate synthase large subunit
APPLDMEG_01538	4.54e-197	XK27_05675	-	-	S	-	-	-	Esterase
APPLDMEG_01539	2.17e-205	XK27_05670	-	-	S	ko:K07017	-	ko00000	Putative esterase
APPLDMEG_01540	0.0	gapN	1.2.1.9	-	C	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
APPLDMEG_01541	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APPLDMEG_01542	2.72e-51	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein Hpr
APPLDMEG_01543	4.67e-279	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate dehydrogenase
APPLDMEG_01544	1.94e-267	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
APPLDMEG_01545	0.0	acnA	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APPLDMEG_01546	1.37e-45	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
APPLDMEG_01547	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPLDMEG_01548	4.51e-236	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APPLDMEG_01549	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APPLDMEG_01550	3.37e-192	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
APPLDMEG_01551	2.54e-175	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
APPLDMEG_01552	1.95e-41	yggT	-	-	D	ko:K02221	-	ko00000,ko02044	integral membrane protein
APPLDMEG_01553	6.2e-123	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	cell septum assembly
APPLDMEG_01554	7.71e-157	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APPLDMEG_01555	1.4e-298	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APPLDMEG_01556	1.16e-290	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
APPLDMEG_01557	1.56e-187	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
APPLDMEG_01558	7.12e-254	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APPLDMEG_01559	5.27e-315	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APPLDMEG_01560	3.66e-12	-	-	-	S	-	-	-	Protein of unknown function (DUF3165)
APPLDMEG_01561	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
APPLDMEG_01562	1.88e-225	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
APPLDMEG_01563	7.59e-37	yqgQ	-	-	S	-	-	-	protein conserved in bacteria
APPLDMEG_01564	8.12e-103	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
APPLDMEG_01565	8.39e-114	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
APPLDMEG_01566	6.13e-129	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type II secretory pathway prepilin signal peptidase PulO and related peptidases
APPLDMEG_01567	2.11e-215	-	-	-	V	-	-	-	D-alanyl-D-alanine carboxypeptidase
APPLDMEG_01568	1.31e-142	sodA	1.15.1.1	-	C	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
APPLDMEG_01569	3.81e-233	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
APPLDMEG_01570	0.0	ppc	4.1.1.31	-	H	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APPLDMEG_01571	9.31e-84	-	-	-	S	-	-	-	Domain of unknown function (DUF4430)
APPLDMEG_01572	4.98e-96	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	Psort location CytoplasmicMembrane, score
APPLDMEG_01573	9.65e-163	sitB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K10830,ko:K11706,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_01574	1.01e-171	mtsC	-	-	P	ko:K11705,ko:K19972,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type Mn2 Zn2 transport systems, permease components
APPLDMEG_01575	1.13e-219	psaA	-	-	P	ko:K11704,ko:K19971,ko:K19975,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
APPLDMEG_01576	3.4e-145	sirR	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
APPLDMEG_01577	8.1e-188	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
APPLDMEG_01578	8.87e-120	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
APPLDMEG_01579	5.85e-230	spd	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
APPLDMEG_01580	0.0	-	-	-	M	-	-	-	Right handed beta helix region
APPLDMEG_01581	4.51e-184	-	-	-	S	-	-	-	double-stranded DNA endodeoxyribonuclease activity
APPLDMEG_01582	6.12e-235	-	-	-	L	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
APPLDMEG_01583	9.92e-58	-	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
APPLDMEG_01584	1.09e-172	sdh	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
APPLDMEG_01585	4.57e-251	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
APPLDMEG_01586	4.89e-146	-	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APPLDMEG_01587	2.32e-198	hmpP2	-	-	G	-	-	-	hydrolase
APPLDMEG_01588	9.26e-35	-	-	-	P	-	-	-	Hemerythrin HHE cation binding domain protein
APPLDMEG_01589	5.34e-192	-	3.5.1.28	-	M	ko:K01447,ko:K07273	-	ko00000,ko01000	Glycosyl hydrolase, family 25
APPLDMEG_01590	2.39e-103	-	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APPLDMEG_01591	1.2e-148	pgm	-	-	G	-	-	-	Phosphoglycerate mutase
APPLDMEG_01593	3.26e-224	-	-	-	S	ko:K07025	-	ko00000	hydrolase
APPLDMEG_01594	1.73e-36	-	-	-	-	-	-	-	-
APPLDMEG_01595	7.29e-207	-	-	-	M	-	-	-	LysM domain
APPLDMEG_01596	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
APPLDMEG_01598	5.9e-18	-	-	-	-	-	-	-	-
APPLDMEG_01599	1.33e-294	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
APPLDMEG_01600	2.97e-45	XK27_12190	-	-	S	-	-	-	protein conserved in bacteria
APPLDMEG_01602	6.28e-112	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	biotin synthase
APPLDMEG_01603	0.0	yrrO	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
APPLDMEG_01604	5.02e-228	yrrN	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
APPLDMEG_01606	1.59e-89	ytxH	-	-	S	-	-	-	General stress protein
APPLDMEG_01607	2e-27	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
APPLDMEG_01608	4.15e-188	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APPLDMEG_01609	1.86e-214	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APPLDMEG_01610	1.02e-55	WQ51_05770	-	-	KT	-	-	-	PspC domain
APPLDMEG_01611	0.0	tex	-	-	K	ko:K06959	-	ko00000	Transcriptional accessory protein
APPLDMEG_01613	1.14e-199	XK27_03015	-	-	S	ko:K07089	-	ko00000	permease
APPLDMEG_01614	4.15e-192	XK27_03010	-	-	S	ko:K08986	-	ko00000	TIGR03943 family
APPLDMEG_01615	2.27e-215	-	-	-	S	-	-	-	CRISPR-associated protein Csn2 subfamily St
APPLDMEG_01616	8.44e-71	-	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPLDMEG_01617	1.32e-220	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APPLDMEG_01618	5.9e-313	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APPLDMEG_01619	0.0	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APPLDMEG_01620	0.0	yvdB	-	-	P	ko:K03321	-	ko00000,ko02000	Sulfate permease and related transporters (MFS superfamily)
APPLDMEG_01621	1.39e-134	-	-	-	-	-	-	-	-
APPLDMEG_01622	1.35e-150	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
APPLDMEG_01623	5.79e-122	-	-	-	S	-	-	-	CAAX protease self-immunity
APPLDMEG_01624	2.62e-68	-	-	-	-	-	-	-	-
APPLDMEG_01626	8.28e-84	yqeB	-	-	S	-	-	-	Pyrimidine dimer DNA glycosylase
APPLDMEG_01627	2.78e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF1722)
APPLDMEG_01628	7.77e-31	-	-	-	M	-	-	-	Bacterial lipoprotein
APPLDMEG_01630	3.81e-166	-	-	-	V	-	-	-	CAAX protease self-immunity
APPLDMEG_01631	4.44e-62	-	-	-	-	-	-	-	-
APPLDMEG_01632	6.57e-84	-	-	-	K	-	-	-	TetR family transcriptional regulator
APPLDMEG_01633	8.82e-109	-	-	-	Q	-	-	-	Methyltransferase domain
APPLDMEG_01634	3.28e-180	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
APPLDMEG_01635	2.16e-221	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	dehydrogenase E1 component
APPLDMEG_01636	2.5e-211	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	Acetoin dehydrogenase E1 component subunit alpha
APPLDMEG_01637	2.8e-218	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
APPLDMEG_01638	4.51e-24	-	-	-	K	-	-	-	CsbD-like
APPLDMEG_01639	7.79e-25	-	-	-	K	-	-	-	CsbD-like
APPLDMEG_01640	5.37e-94	-	-	-	S	-	-	-	Asp23 family, cell envelope-related function
APPLDMEG_01641	1.78e-31	-	-	-	S	-	-	-	Small integral membrane protein
APPLDMEG_01642	3.29e-124	-	-	-	-	-	-	-	-
APPLDMEG_01643	6.33e-42	ytgB	-	-	S	-	-	-	Membrane
APPLDMEG_01645	1e-218	-	-	-	S	-	-	-	Domain of unknown function (DUF389)
APPLDMEG_01646	1.7e-202	yegS	-	-	I	-	-	-	Diacylglycerol kinase
APPLDMEG_01647	1.32e-159	-	-	-	S	-	-	-	Putative esterase
APPLDMEG_01648	2.12e-230	fatB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
APPLDMEG_01649	3.94e-171	fecE	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
APPLDMEG_01650	1.43e-217	fecD	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APPLDMEG_01651	1.47e-147	-	-	-	V	-	-	-	CAAX protease self-immunity
APPLDMEG_01652	5.82e-187	-	-	-	S	-	-	-	Domain of unknown function (DUF4300)
APPLDMEG_01653	1.14e-119	tetR	-	-	K	-	-	-	transcriptional regulator
APPLDMEG_01654	0.0	-	-	-	P	-	-	-	Major facilitator superfamily
APPLDMEG_01655	1.9e-19	yjdB	-	-	S	-	-	-	Domain of unknown function (DUF4767)
APPLDMEG_01657	5.21e-138	cutC	-	-	P	ko:K06201	-	ko00000	Participates in the control of copper homeostasis
APPLDMEG_01658	1.02e-163	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family
APPLDMEG_01659	3.61e-123	yagB	-	-	F	ko:K06950	-	ko00000	HD superfamily hydrolase
APPLDMEG_01660	9.47e-124	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
APPLDMEG_01661	2.79e-190	ChZ00x2	-	-	S	-	-	-	EDD domain protein, DegV family
APPLDMEG_01662	7.69e-257	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	transporter
APPLDMEG_01663	6.83e-169	-	-	-	S	-	-	-	Domain of unknown function (DUF4336)
APPLDMEG_01664	9.19e-169	-	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
APPLDMEG_01665	1.04e-17	-	-	-	-	-	-	-	-
APPLDMEG_01666	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
APPLDMEG_01667	3.39e-165	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_01668	4.39e-145	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation, permease component
APPLDMEG_01669	3.57e-144	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
APPLDMEG_01670	2.39e-104	-	3.4.15.6	-	PQ	ko:K13282	-	ko00000,ko01000,ko01002	Peptidase family S51
APPLDMEG_01671	4.29e-101	-	2.3.1.82	-	K	ko:K18816	-	br01600,ko00000,ko01000,ko01504	Acetyltransferase (GNAT) family
APPLDMEG_01673	2.92e-10	-	-	-	-	-	-	-	-
APPLDMEG_01674	4.17e-240	XK27_10075	-	-	S	-	-	-	abc transporter atp-binding protein
APPLDMEG_01675	0.0	ndvA	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_01676	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_01677	0.0	gshF	6.3.2.2	-	H	ko:K01919,ko:K16786,ko:K16787	ko00270,ko00480,ko01100,ko02010,map00270,map00480,map01100,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the glutamate--cysteine ligase type 1 family
APPLDMEG_01681	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
APPLDMEG_01682	1.13e-131	-	-	-	K	-	-	-	Acetyltransferase GNAT Family
APPLDMEG_01683	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
APPLDMEG_01684	0.0	glgA	2.4.1.21	GT5	G	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000,ko01003	Synthesizes alpha-1,4-glucan chains using ADP-glucose
APPLDMEG_01685	1.89e-228	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	glucose-1-phosphate adenylyltransferase
APPLDMEG_01686	1.47e-249	glgC	2.7.7.27	-	H	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APPLDMEG_01687	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APPLDMEG_01688	0.0	pulA	3.2.1.41	CBM48,GH13	G	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
APPLDMEG_01689	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
APPLDMEG_01690	3.19e-238	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
APPLDMEG_01691	1.15e-173	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
APPLDMEG_01692	1.3e-121	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APPLDMEG_01695	5.45e-146	vraR	-	-	K	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
APPLDMEG_01696	3.44e-219	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
APPLDMEG_01697	3.48e-151	yvqF	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Membrane
APPLDMEG_01698	1.42e-133	-	-	-	P	ko:K10716	-	ko00000,ko02000	Ion transport protein
APPLDMEG_01699	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
APPLDMEG_01700	2.57e-173	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
APPLDMEG_01701	2.77e-306	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APPLDMEG_01702	2.26e-216	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APPLDMEG_01703	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APPLDMEG_01704	1.37e-61	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-directed 5'-3' RNA polymerase activity
APPLDMEG_01705	4.34e-145	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
APPLDMEG_01706	2.15e-278	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APPLDMEG_01707	3.12e-183	XK27_02985	-	-	S	-	-	-	overlaps another CDS with the same product name
APPLDMEG_01708	3.69e-187	-	-	-	S	-	-	-	overlaps another CDS with the same product name
APPLDMEG_01709	4.71e-81	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional
APPLDMEG_01710	5.01e-160	skfE	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
APPLDMEG_01711	1.06e-164	-	-	-	V	-	-	-	Psort location CytoplasmicMembrane, score
APPLDMEG_01712	1.94e-216	amiF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
APPLDMEG_01713	8.06e-258	amiE	-	-	P	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
APPLDMEG_01714	4.52e-210	amiD	-	-	P	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_01715	0.0	amiC	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter (Permease
APPLDMEG_01716	0.0	amiA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
APPLDMEG_01717	0.0	amiA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
APPLDMEG_01718	1.87e-223	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
APPLDMEG_01719	3.5e-218	yjbO	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
APPLDMEG_01720	2.81e-196	nadK	2.7.1.23	-	H	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APPLDMEG_01721	5.79e-154	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	Gtp pyrophosphokinase
APPLDMEG_01722	3.35e-131	yjbK	-	-	S	-	-	-	Adenylate cyclase
APPLDMEG_01723	8.28e-225	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APPLDMEG_01724	5.53e-265	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
APPLDMEG_01725	1.52e-79	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
APPLDMEG_01726	3.84e-153	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APPLDMEG_01727	1.57e-167	-	-	-	T	ko:K07010	-	ko00000,ko01002	peptidase C26
APPLDMEG_01728	5.39e-153	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
APPLDMEG_01729	0.0	rgpF	-	-	M	ko:K07272	-	ko00000,ko01000,ko01003,ko01005	Rhamnan synthesis protein F
APPLDMEG_01730	1.83e-234	rgpEc	-	GT2	M	ko:K12998	-	ko00000,ko01000,ko01003,ko01005	Glycosyl transferase family 2
APPLDMEG_01731	4.05e-285	rgpD	3.6.3.40	-	P	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
APPLDMEG_01732	1.07e-181	rgpC	-	-	GM	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
APPLDMEG_01733	6.02e-220	rgpB	-	GT2	M	ko:K12997	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
APPLDMEG_01734	2.1e-272	rgpA	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	Domain of unknown function (DUF1972)
APPLDMEG_01735	2.64e-172	-	-	-	S	-	-	-	Predicted membrane protein (DUF2142)
APPLDMEG_01736	2.31e-161	-	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	transferase activity, transferring glycosyl groups
APPLDMEG_01737	3.35e-273	rgpX3	-	-	S	-	-	-	polysaccharide biosynthetic process
APPLDMEG_01738	2.12e-61	-	-	-	S	ko:K09153	-	ko00000	Uncharacterized conserved protein (DUF2304)
APPLDMEG_01739	1.14e-159	-	-	-	S	-	-	-	Glycosyl transferase family 2
APPLDMEG_01740	5.74e-205	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
APPLDMEG_01741	6.51e-307	-	-	-	-	-	-	-	-
APPLDMEG_01742	1.04e-215	yfdH	-	GT2	M	ko:K12999,ko:K20534	-	ko00000,ko01000,ko01003,ko01005,ko02000	COG0463, glycosyltransferases involved in cell wall biogenesis
APPLDMEG_01743	1.43e-73	yitW	-	-	K	-	-	-	metal-sulfur cluster biosynthetic enzyme
APPLDMEG_01744	2.49e-256	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
APPLDMEG_01745	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
APPLDMEG_01746	2.93e-65	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
APPLDMEG_01747	8.61e-28	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
APPLDMEG_01748	3.34e-174	artP	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
APPLDMEG_01749	4.9e-263	arcT	-	-	E	-	-	-	Aminotransferase
APPLDMEG_01750	7.33e-176	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
APPLDMEG_01751	1.65e-177	XK27_04395	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter
APPLDMEG_01752	1.29e-101	XK27_04400	3.6.1.55	-	F	ko:K03574,ko:K12944	-	ko00000,ko01000,ko03400	Nudix family
APPLDMEG_01753	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
APPLDMEG_01755	3.85e-208	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family protein
APPLDMEG_01756	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type amino acid transport signal transduction systems periplasmic component domain
APPLDMEG_01757	2.39e-174	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	abc transporter atp-binding protein
APPLDMEG_01758	5.23e-25	XK27_00735	-	-	-	-	-	-	-
APPLDMEG_01759	7.8e-315	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APPLDMEG_01760	9.86e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
APPLDMEG_01761	3.48e-161	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
APPLDMEG_01762	2.83e-08	-	-	-	O	-	-	-	ADP-ribosylglycohydrolase
APPLDMEG_01763	2.33e-81	-	-	-	Q	ko:K02614	ko00360,map00360	ko00000,ko00001,ko01000	protein possibly involved in aromatic compounds catabolism
APPLDMEG_01764	1.43e-80	ycaO	-	-	O	ko:K06889,ko:K07397,ko:K09136	-	ko00000,ko03009	OsmC-like protein
APPLDMEG_01766	2.86e-191	-	-	-	EG	-	-	-	Permeases of the drug metabolite transporter (DMT) superfamily
APPLDMEG_01768	8.17e-285	-	-	-	NU	-	-	-	GBS Bsp-like repeat
APPLDMEG_01769	2.8e-172	agrA	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
APPLDMEG_01770	7.31e-289	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
APPLDMEG_01771	0.0	-	-	-	NU	-	-	-	GBS Bsp-like repeat
APPLDMEG_01773	0.0	-	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
APPLDMEG_01774	1.61e-179	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
APPLDMEG_01775	8.81e-285	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	mutations do not affect methionine salvage in vivo however
APPLDMEG_01776	2.7e-234	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APPLDMEG_01777	3.17e-280	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APPLDMEG_01778	4.35e-156	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
APPLDMEG_01779	2.13e-256	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
APPLDMEG_01780	4.94e-190	icaB	-	-	G	-	-	-	deacetylase
APPLDMEG_01781	8.5e-303	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
APPLDMEG_01782	5.87e-195	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
APPLDMEG_01783	4.95e-191	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	Transporter
APPLDMEG_01785	1.38e-17	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
APPLDMEG_01788	3.31e-130	-	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APPLDMEG_01789	7.96e-127	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
APPLDMEG_01791	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
APPLDMEG_01792	0.0	-	-	-	S	-	-	-	AAA ATPase domain
APPLDMEG_01793	5.88e-23	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APPLDMEG_01794	2.87e-156	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
APPLDMEG_01795	2.09e-85	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APPLDMEG_01796	8.62e-114	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APPLDMEG_01797	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APPLDMEG_01798	9.08e-202	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APPLDMEG_01799	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APPLDMEG_01800	1.24e-89	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
APPLDMEG_01801	5.84e-277	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
APPLDMEG_01802	3.2e-285	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APPLDMEG_01803	7.68e-174	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
APPLDMEG_01804	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APPLDMEG_01806	4.66e-140	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APPLDMEG_01807	5.07e-203	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	dna polymerase iii
APPLDMEG_01808	4.74e-176	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
APPLDMEG_01809	2e-73	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
APPLDMEG_01810	9.87e-204	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APPLDMEG_01811	6.34e-32	amt	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium Transporter
APPLDMEG_01812	5.99e-136	mur1	3.4.17.14, 3.5.1.28	-	NU	ko:K01448,ko:K02395,ko:K07260	ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036	amidase activity
APPLDMEG_01813	4.78e-52	-	-	-	S	ko:K07023	-	ko00000	HD domain
APPLDMEG_01814	1.78e-51	-	-	-	S	ko:K07023	-	ko00000	HD domain
APPLDMEG_01815	2.61e-180	XK27_04800	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
APPLDMEG_01816	1.75e-97	-	-	-	S	-	-	-	Bacterial inner membrane protein
APPLDMEG_01817	2.71e-150	-	3.4.17.14, 3.5.1.28	-	NU	ko:K01448,ko:K02395,ko:K07260	ko00550,ko01100,ko01502,ko01503,ko02020,map00550,map01100,map01502,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02035,ko03036	amidase activity
APPLDMEG_01818	0.0	yjbB	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
APPLDMEG_01819	1.54e-274	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APPLDMEG_01820	3.19e-268	-	-	-	S	-	-	-	membrane
APPLDMEG_01821	1.23e-226	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
APPLDMEG_01822	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
APPLDMEG_01823	1.17e-51	ynzC	-	-	S	-	-	-	UPF0291 protein
APPLDMEG_01824	0.0	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	permease
APPLDMEG_01826	0.0	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01827	7.15e-179	ppiA	5.2.1.8	-	O	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	ko00000,ko00001,ko01000,ko03110,ko04147	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APPLDMEG_01831	3.98e-09	-	-	-	S	-	-	-	Protein of unknown function, DUF600
APPLDMEG_01832	1.56e-200	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
APPLDMEG_01833	3.64e-70	-	-	-	V	-	-	-	ABC-2 type transporter
APPLDMEG_01834	7.28e-124	-	-	-	-	-	-	-	-
APPLDMEG_01836	6.02e-216	lysR	-	-	K	-	-	-	transcriptional regulator (lysR family)
APPLDMEG_01837	5.69e-100	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APPLDMEG_01838	1.03e-207	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
APPLDMEG_01839	5.91e-114	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APPLDMEG_01840	1.16e-280	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	uracil Permease
APPLDMEG_01841	3.93e-220	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
APPLDMEG_01842	7.9e-270	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	carbamoyl-phosphate synthetase glutamine chain
APPLDMEG_01843	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	carbamoyl-phosphate synthetase ammonia chain
APPLDMEG_01844	5.37e-169	-	-	-	S	-	-	-	Putative SAM-dependent methyltransferase
APPLDMEG_01845	7.64e-250	-	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APPLDMEG_01846	1.13e-157	salX	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
APPLDMEG_01847	1.32e-270	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	permease protein
APPLDMEG_01848	8.41e-102	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APPLDMEG_01849	5.52e-65	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
APPLDMEG_01852	6.94e-209	-	-	-	K	ko:K20342,ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
APPLDMEG_01853	0.0	-	-	-	NU	-	-	-	GBS Bsp-like repeat
APPLDMEG_01854	2.89e-11	-	-	-	-	-	-	-	-
APPLDMEG_01856	0.0	-	-	-	M	-	-	-	GBS Bsp-like repeat
APPLDMEG_01857	1.02e-40	-	-	-	KT	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	response regulator
APPLDMEG_01858	1.47e-59	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
APPLDMEG_01859	5.36e-123	-	-	-	K	-	-	-	transcriptional regulator PlcR
APPLDMEG_01863	2.41e-173	-	-	-	KLT	-	-	-	Protein kinase domain
APPLDMEG_01864	9.14e-116	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
APPLDMEG_01865	5.66e-116	-	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
APPLDMEG_01868	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APPLDMEG_01869	5.39e-111	XK27_03390	-	-	S	-	-	-	LURP-one-related
APPLDMEG_01870	2.64e-236	prsA	3.1.3.16, 5.2.1.8	-	O	ko:K01802,ko:K03769,ko:K07533,ko:K20074	-	ko00000,ko01000,ko01009,ko03110	peptidyl-prolyl cis-trans isomerase activity
APPLDMEG_01871	5.91e-155	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-Methyltransferase
APPLDMEG_01872	5.81e-275	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
APPLDMEG_01873	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
APPLDMEG_01874	1.35e-212	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
APPLDMEG_01875	0.0	-	-	-	S	-	-	-	Glucan-binding protein C
APPLDMEG_01876	6.34e-138	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease family protein
APPLDMEG_01877	3.03e-215	-	-	-	K	-	-	-	transcriptional regulator (lysR family)
APPLDMEG_01878	2.43e-205	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
APPLDMEG_01879	6.68e-199	-	-	-	L	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
APPLDMEG_01881	1.1e-116	-	-	-	L	-	-	-	DNA synthesis involved in DNA repair
APPLDMEG_01882	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APPLDMEG_01886	6.93e-239	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
APPLDMEG_01887	1.13e-206	sip	-	-	M	-	-	-	LysM domain protein
APPLDMEG_01888	2.72e-46	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
APPLDMEG_01889	3.88e-204	yitL	-	-	S	ko:K00243	-	ko00000	Protein conserved in bacteria
APPLDMEG_01890	1.94e-118	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
APPLDMEG_01891	2.78e-168	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
APPLDMEG_01892	6.48e-269	sptS	-	-	T	-	-	-	Histidine kinase
APPLDMEG_01893	4.8e-150	dltr	-	-	T	-	-	-	response regulator
APPLDMEG_01894	2.07e-142	-	2.7.6.5	-	S	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	Region found in RelA / SpoT proteins
APPLDMEG_01895	2.06e-140	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
APPLDMEG_01896	0.0	lmrA2	-	-	V	ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_01897	0.0	lmrA1	-	-	V	ko:K02021,ko:K06147	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_01898	3.21e-94	-	-	-	K	-	-	-	DNA-binding transcription factor activity
APPLDMEG_01899	7.84e-92	def_1	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
APPLDMEG_01900	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
APPLDMEG_01901	0.0	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
APPLDMEG_01902	7.31e-269	nadR	-	-	H	-	-	-	adenylyltransferase
APPLDMEG_01903	8.52e-167	-	-	-	F	-	-	-	AdP-ribose pyrophosphatase
APPLDMEG_01904	6.23e-30	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
APPLDMEG_01905	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	abc transporter atp-binding protein
APPLDMEG_01906	3.15e-277	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APPLDMEG_01907	2.58e-178	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
APPLDMEG_01908	2.67e-188	-	-	-	S	-	-	-	EDD domain protein, DegV family
APPLDMEG_01909	2.63e-82	WQ51_03320	-	-	S	-	-	-	cog cog4835
APPLDMEG_01910	4.68e-169	ydaF_2	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APPLDMEG_01911	1.55e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
APPLDMEG_01912	1.99e-64	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
APPLDMEG_01913	1.47e-105	-	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	acetyltransferase
APPLDMEG_01914	0.0	gtf2	-	-	M	-	-	-	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1
APPLDMEG_01915	0.0	gtf1	-	-	M	-	-	-	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
APPLDMEG_01916	5.31e-284	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APPLDMEG_01917	3.49e-269	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes
APPLDMEG_01918	1.4e-07	-	-	-	-	-	-	-	-
APPLDMEG_01919	6.22e-283	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
APPLDMEG_01920	0.0	gor	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APPLDMEG_01921	0.0	fruA	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
APPLDMEG_01922	1.12e-212	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
APPLDMEG_01923	3.75e-163	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	transcriptional
APPLDMEG_01924	6.36e-290	rny	-	-	D	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
APPLDMEG_01925	6.58e-116	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
APPLDMEG_01926	3.26e-177	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
APPLDMEG_01927	2.95e-205	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APPLDMEG_01928	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
APPLDMEG_01929	1.19e-93	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
APPLDMEG_01930	1.81e-85	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
APPLDMEG_01931	2.13e-296	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
APPLDMEG_01932	3.92e-163	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
APPLDMEG_01933	1.51e-207	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
APPLDMEG_01934	2.65e-220	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	2-Nitropropane dioxygenase
APPLDMEG_01935	2.12e-40	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APPLDMEG_01936	2.45e-220	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APPLDMEG_01937	1.81e-94	XK27_02735	-	-	K	-	-	-	Transcriptional regulator, MarR family
APPLDMEG_01938	5.57e-180	phaB	5.3.3.14, 5.3.3.18	-	I	ko:K15866,ko:K18474	ko00061,ko00360,ko01120,map00061,map00360,map01120	ko00000,ko00001,ko01000,ko01004	Belongs to the enoyl-CoA hydratase isomerase family
APPLDMEG_01939	1.52e-151	yhfA	-	-	S	-	-	-	HAD hydrolase, family IA, variant 3
APPLDMEG_01940	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
APPLDMEG_01941	3.09e-244	asnA	6.3.1.1	-	E	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
APPLDMEG_01942	7.59e-314	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APPLDMEG_01943	5.17e-175	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
APPLDMEG_01944	1.99e-132	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
APPLDMEG_01945	2.19e-132	-	-	-	S	-	-	-	Domain of unknown function (DUF1803)
APPLDMEG_01946	6.16e-209	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
APPLDMEG_01954	6.78e-42	yozG	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
APPLDMEG_01958	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APPLDMEG_01959	2.71e-259	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APPLDMEG_01960	2.5e-79	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
APPLDMEG_01961	1.82e-247	aroG	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APPLDMEG_01962	1.18e-250	aroH	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APPLDMEG_01963	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
APPLDMEG_01965	8.8e-241	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
APPLDMEG_01966	3.78e-217	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	Fructokinase
APPLDMEG_01967	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
APPLDMEG_01968	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
APPLDMEG_01969	1.28e-227	scrR	-	-	K	ko:K03484	-	ko00000,ko03000	Transcriptional regulator
APPLDMEG_01970	1.09e-95	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APPLDMEG_01971	7.41e-80	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	protein conserved in bacteria
APPLDMEG_01972	8.59e-127	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APPLDMEG_01973	3.59e-111	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
APPLDMEG_01974	3.97e-254	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Belongs to the peptidase M24B family
APPLDMEG_01976	4.27e-186	-	-	-	V	ko:K01990,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	'abc transporter, ATP-binding protein
APPLDMEG_01977	5.2e-38	blpT	-	-	-	-	-	-	-
APPLDMEG_01981	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APPLDMEG_01982	2.34e-215	corA	-	-	P	ko:K03284	-	ko00000,ko02000	COG0598 Mg2 and Co2 transporters
APPLDMEG_01983	1.14e-156	XK27_01040	-	-	S	-	-	-	Protein of unknown function (DUF1129)
APPLDMEG_01985	4.1e-47	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APPLDMEG_01986	4.18e-118	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
APPLDMEG_01987	1.88e-62	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
APPLDMEG_01988	6.33e-52	XK27_05745	-	-	-	-	-	-	-
APPLDMEG_01989	4.83e-277	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific adenine glycosylase
APPLDMEG_01991	3.17e-31	-	-	-	-	-	-	-	-
APPLDMEG_01993	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APPLDMEG_01994	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
APPLDMEG_01995	7.99e-120	cvpA	-	-	S	ko:K03558	-	ko00000	toxin biosynthetic process
APPLDMEG_01996	1.18e-20	-	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APPLDMEG_01997	4.47e-196	rnhC	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APPLDMEG_01998	6.48e-136	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
APPLDMEG_01999	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
APPLDMEG_02000	1.14e-62	-	-	-	S	-	-	-	branched-chain amino acid
APPLDMEG_02001	4.68e-144	XK27_12120	-	-	E	-	-	-	AzlC protein
APPLDMEG_02002	2.72e-237	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APPLDMEG_02003	8.68e-95	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
APPLDMEG_02004	3.81e-152	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214, inactive homolog of metal-dependent proteases
APPLDMEG_02005	4.54e-45	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
APPLDMEG_02006	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APPLDMEG_02007	1.12e-286	-	-	-	L	ko:K07485	-	ko00000	Transposase
APPLDMEG_02008	4.18e-148	sle1	3.5.1.28	CBM50	M	ko:K22409	-	ko00000,ko01000	CHAP domain protein
APPLDMEG_02009	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
APPLDMEG_02010	4e-82	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	Transcriptional regulator
APPLDMEG_02011	4.38e-113	-	-	-	S	-	-	-	Fusaric acid resistance protein-like
APPLDMEG_02012	3.32e-283	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
APPLDMEG_02013	9.29e-157	-	-	-	-	-	-	-	-
APPLDMEG_02014	4.47e-231	gap	1.2.1.12	-	C	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
APPLDMEG_02015	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APPLDMEG_02016	4.66e-105	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
APPLDMEG_02017	4.89e-91	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APPLDMEG_02018	7.91e-184	purR	-	-	F	ko:K09685	-	ko00000,ko03000	operon repressor
APPLDMEG_02019	4.14e-229	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	3'-5' exoribonuclease yhaM
APPLDMEG_02020	1.62e-229	rmuC	-	-	S	ko:K09760	-	ko00000	RmuC domain protein
APPLDMEG_02021	4.53e-146	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
APPLDMEG_02022	1.15e-154	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
APPLDMEG_02023	8.83e-208	rsgA	3.1.3.100	-	G	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
APPLDMEG_02025	8.34e-197	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
APPLDMEG_02026	2.57e-128	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
APPLDMEG_02027	2.16e-181	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	Hydrolase, tatd
APPLDMEG_02028	2.29e-92	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
APPLDMEG_02029	1.27e-66	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
APPLDMEG_02030	1.18e-181	-	-	-	S	-	-	-	Macro domain protein
APPLDMEG_02031	2.05e-76	yneP	-	-	L	ko:K07107	-	ko00000,ko01000	thioesterase
APPLDMEG_02032	6.07e-66	bta	1.8.1.8	-	CO	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko03110	cell redox homeostasis