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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
MHALACOG_00001	4.31e-22	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MHALACOG_00002	1.85e-53	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
MHALACOG_00003	0.0	glgX	3.2.1.196, 3.2.1.68	CBM48,GH13	G	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 13 family
MHALACOG_00004	1.63e-95	glgX	3.2.1.196, 3.2.1.68	CBM48,GH13	G	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 13 family
MHALACOG_00005	3.92e-290	-	-	-	GK	-	-	-	transcriptional repressor of nag (N-acetylglucosamine) operon K02565
MHALACOG_00006	2.36e-212	adhE	1.1.1.1, 1.2.1.10, 1.2.1.81	-	C	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
MHALACOG_00007	0.0	adhE	1.1.1.1, 1.2.1.10, 1.2.1.81	-	C	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
MHALACOG_00008	3.04e-201	-	-	-	S	-	-	-	YwiC-like protein
MHALACOG_00009	9.35e-68	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
MHALACOG_00010	1.11e-149	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MHALACOG_00011	1.97e-150	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
MHALACOG_00012	8.86e-62	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MHALACOG_00013	2.23e-194	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MHALACOG_00014	1.4e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MHALACOG_00015	1.55e-74	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MHALACOG_00016	1.32e-161	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MHALACOG_00017	6.4e-97	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MHALACOG_00018	1.97e-49	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
MHALACOG_00019	1.11e-54	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MHALACOG_00020	2.55e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MHALACOG_00021	1.09e-68	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MHALACOG_00022	2.77e-134	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MHALACOG_00023	7.06e-40	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MHALACOG_00024	3.17e-90	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MHALACOG_00025	6.34e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MHALACOG_00026	1.79e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MHALACOG_00027	4.66e-127	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MHALACOG_00028	4.64e-36	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30p/L7e
MHALACOG_00029	1.52e-98	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MHALACOG_00030	6.89e-313	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MHALACOG_00031	1.49e-127	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MHALACOG_00032	6.91e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MHALACOG_00033	1.47e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
MHALACOG_00034	1.16e-81	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MHALACOG_00035	7.34e-86	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MHALACOG_00036	4.01e-236	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MHALACOG_00037	1.6e-94	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
MHALACOG_00038	1.22e-216	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MHALACOG_00039	0.0	gcs2	-	-	S	ko:K06048	-	ko00000,ko01000	A circularly permuted ATPgrasp
MHALACOG_00040	2.62e-197	-	-	-	E	-	-	-	Transglutaminase/protease-like homologues
MHALACOG_00042	0.0	-	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	arabinose metabolic process
MHALACOG_00044	4.12e-253	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_00045	3.17e-157	-	-	-	-	-	-	-	-
MHALACOG_00046	2.53e-242	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
MHALACOG_00047	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MHALACOG_00048	1.04e-95	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MHALACOG_00049	6.5e-268	truB	5.4.99.25	-	J	ko:K03177	-	ko00000,ko01000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MHALACOG_00050	7.35e-272	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	riboflavin kinase
MHALACOG_00051	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MHALACOG_00052	2.46e-131	-	-	-	-	-	-	-	-
MHALACOG_00053	5.05e-07	-	-	-	S	-	-	-	Mitochondrial domain of unknown function (DUF1713)
MHALACOG_00054	2.04e-159	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MHALACOG_00055	3.69e-194	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MHALACOG_00057	0.0	merA	1.16.1.1	-	C	ko:K00520,ko:K21739	-	ko00000,ko01000	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MHALACOG_00058	4.67e-95	-	-	-	K	-	-	-	Transcriptional regulator
MHALACOG_00059	1.36e-248	-	-	-	S	-	-	-	Protein conserved in bacteria
MHALACOG_00060	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
MHALACOG_00061	0.0	-	-	-	U	-	-	-	Fungal trichothecene efflux pump (TRI12)
MHALACOG_00062	0.0	ptsG	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system, glucose-specific IIABC component
MHALACOG_00063	3.72e-194	arbG	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
MHALACOG_00064	1.79e-268	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
MHALACOG_00065	2.18e-305	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MHALACOG_00067	3.83e-22	-	-	-	-	-	-	-	-
MHALACOG_00068	3.05e-282	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_00069	3.24e-206	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00070	3.17e-211	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	ABC transporter permease
MHALACOG_00071	0.0	gnpA	2.4.1.211	-	S	ko:K15533	-	ko00000,ko01000	Lacto-N-biose phosphorylase C-terminal domain
MHALACOG_00072	8.4e-259	-	2.7.1.162	-	S	ko:K13059	-	ko00000,ko01000	Phosphotransferase enzyme family
MHALACOG_00073	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MHALACOG_00074	7.93e-227	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MHALACOG_00075	9.57e-143	tcsR3	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00076	1.85e-291	tcsS3	-	-	KT	-	-	-	PspC domain
MHALACOG_00077	2.27e-218	pspC	-	-	KT	-	-	-	PspC domain
MHALACOG_00078	1.71e-98	-	-	-	-	-	-	-	-
MHALACOG_00079	0.0	-	-	-	S	ko:K06889	-	ko00000	alpha beta
MHALACOG_00080	6.65e-145	-	-	-	S	-	-	-	Protein of unknown function (DUF4125)
MHALACOG_00081	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4037)
MHALACOG_00082	2.81e-278	-	-	-	EGP	ko:K08156,ko:K19577	-	ko00000,ko02000	Major Facilitator Superfamily
MHALACOG_00084	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
MHALACOG_00085	1.35e-213	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the MenA family. Type 1 subfamily
MHALACOG_00086	3.69e-178	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MHALACOG_00087	6.31e-150	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
MHALACOG_00088	2.91e-246	senX3	2.7.13.3	-	T	ko:K07768	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	ATPase histidine kinase DNA gyrase B HSP90 domain protein
MHALACOG_00089	3.97e-50	-	-	-	-	-	-	-	-
MHALACOG_00090	1.67e-271	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MHALACOG_00091	7.2e-212	-	-	-	S	-	-	-	CHAP domain
MHALACOG_00092	2.94e-119	-	-	-	M	-	-	-	NlpC/P60 family
MHALACOG_00093	1.46e-142	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC/P60 family
MHALACOG_00094	1.16e-242	-	-	-	T	-	-	-	Universal stress protein family
MHALACOG_00095	9.14e-96	-	-	-	O	-	-	-	OsmC-like protein
MHALACOG_00096	4.99e-223	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MHALACOG_00098	4.18e-162	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	dihydrofolate reductase
MHALACOG_00099	7.25e-128	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	low molecular weight
MHALACOG_00100	9e-72	-	-	-	E	-	-	-	Branched-chain amino acid transport protein (AzlD)
MHALACOG_00101	8.26e-192	-	-	-	E	-	-	-	AzlC protein
MHALACOG_00103	6.95e-203	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MHALACOG_00104	6.57e-254	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MHALACOG_00107	1.55e-198	-	-	-	G	-	-	-	Major Facilitator Superfamily
MHALACOG_00108	0.0	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	Mycolic acid cyclopropane synthetase
MHALACOG_00109	1.66e-268	fucO	1.1.1.77, 1.1.99.37, 1.2.98.1	-	C	ko:K00048,ko:K17067	ko00625,ko00630,ko00640,ko00680,ko01120,ko01200,map00625,map00630,map00640,map00680,map01120,map01200	ko00000,ko00001,ko01000	Iron-containing alcohol dehydrogenase
MHALACOG_00110	1.74e-223	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MHALACOG_00111	0.0	-	-	-	S	-	-	-	AI-2E family transporter
MHALACOG_00112	3.4e-296	-	-	-	M	-	-	-	Glycosyl transferase family 21
MHALACOG_00113	2.37e-201	natA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00114	0.0	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
MHALACOG_00115	0.0	dacB	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-Ala-D-Ala carboxypeptidase 3 (S13) family
MHALACOG_00116	1.14e-257	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MHALACOG_00117	2.55e-124	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
MHALACOG_00118	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MHALACOG_00120	1.21e-137	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
MHALACOG_00121	1.14e-199	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MHALACOG_00122	0.0	folK	2.7.6.3, 4.1.2.25	-	H	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MHALACOG_00123	2.92e-115	-	-	-	S	-	-	-	Protein of unknown function (DUF3180)
MHALACOG_00124	4.76e-217	tesB	-	-	I	ko:K10805	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	Thioesterase-like superfamily
MHALACOG_00125	0.0	yjjK	-	-	S	-	-	-	ATP-binding cassette protein, ChvD family
MHALACOG_00127	2.04e-226	glkA	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
MHALACOG_00128	2.49e-197	-	3.6.3.17	-	G	ko:K02056,ko:K10545	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00129	3.01e-274	-	-	-	GK	-	-	-	ROK family
MHALACOG_00130	1.28e-273	-	-	-	G	ko:K10546	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein domain
MHALACOG_00131	0.0	araG	3.6.3.17	-	G	ko:K10548	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00132	4.52e-252	-	-	-	U	ko:K10547	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
MHALACOG_00133	1.37e-54	-	-	-	-	-	-	-	-
MHALACOG_00134	4.5e-104	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MHALACOG_00135	5.31e-28	-	-	-	EGP	-	-	-	Major facilitator superfamily
MHALACOG_00136	5.74e-207	dkg	-	-	S	-	-	-	Oxidoreductase, aldo keto reductase family protein
MHALACOG_00137	6.91e-92	fms	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
MHALACOG_00138	7.83e-199	-	-	-	-	-	-	-	-
MHALACOG_00139	3.78e-28	-	-	-	U	-	-	-	Drug resistance MFS transporter, drug H antiporter-2 family
MHALACOG_00140	2.82e-44	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MHALACOG_00141	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
MHALACOG_00142	9.97e-277	-	-	-	L	-	-	-	Transposase, Mutator family
MHALACOG_00143	4.88e-39	-	-	-	U	ko:K10547	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
MHALACOG_00144	2.67e-49	-	-	-	-	-	-	-	-
MHALACOG_00145	1.76e-40	-	-	-	-	-	-	-	-
MHALACOG_00146	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
MHALACOG_00147	5.56e-287	xylR	-	-	GK	-	-	-	ROK family
MHALACOG_00149	6.44e-49	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the 23S rRNA
MHALACOG_00150	5.53e-245	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MHALACOG_00151	2.83e-199	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MHALACOG_00152	8.52e-268	-	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Receptor family ligand binding region
MHALACOG_00153	3.59e-193	-	-	-	U	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MHALACOG_00154	1.47e-216	-	-	-	U	ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MHALACOG_00155	4.79e-192	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid ATP-binding cassette transporter
MHALACOG_00156	1.61e-157	livF	-	-	E	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00157	1.95e-128	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Bacterial transferase hexapeptide repeat protein
MHALACOG_00158	1.68e-154	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Belongs to the SUA5 family
MHALACOG_00159	6.04e-275	rfe	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	Glycosyl transferase family 4
MHALACOG_00160	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MHALACOG_00161	5.27e-154	orn	-	-	L	ko:K13288	ko03008,map03008	ko00000,ko00001,ko01000,ko03009,ko03019	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MHALACOG_00162	0.0	-	-	-	L	-	-	-	PIF1-like helicase
MHALACOG_00163	0.0	-	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
MHALACOG_00164	8.89e-170	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MHALACOG_00165	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MHALACOG_00166	1.2e-77	ssb2	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
MHALACOG_00167	0.0	pepO	3.4.24.11, 3.4.24.71	-	O	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	Peptidase family M13
MHALACOG_00168	4.92e-191	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
MHALACOG_00169	5.29e-194	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
MHALACOG_00170	0.0	gltA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Citrate synthase, C-terminal domain
MHALACOG_00171	1.27e-227	dapD	2.3.1.117	-	E	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
MHALACOG_00172	7.61e-272	-	-	-	K	-	-	-	WYL domain
MHALACOG_00173	0.0	-	-	-	KL	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00175	7.53e-101	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
MHALACOG_00176	2.62e-107	vsr	-	-	L	ko:K07458	-	ko00000,ko01000,ko03400	May nick specific sequences that contain T G mispairs resulting from m5C-deamination
MHALACOG_00177	1.04e-248	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
MHALACOG_00178	8.35e-297	aspB	2.6.1.1, 2.6.1.2, 2.6.1.66	-	E	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class-V
MHALACOG_00179	5.03e-230	ppx1	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	Ppx/GppA phosphatase family
MHALACOG_00180	2.03e-251	-	-	-	S	ko:K18353	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01504	Endonuclease/Exonuclease/phosphatase family
MHALACOG_00182	1.72e-85	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
MHALACOG_00183	6.34e-103	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
MHALACOG_00184	2.13e-100	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MHALACOG_00185	0.0	-	6.2.1.3	-	I	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme
MHALACOG_00186	5.28e-122	ywrO	-	-	S	-	-	-	Flavodoxin-like fold
MHALACOG_00187	3.31e-58	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MHALACOG_00188	0.0	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MHALACOG_00189	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Anaerobic ribonucleoside-triphosphate reductase
MHALACOG_00190	3.06e-184	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MHALACOG_00191	0.0	hgdC	-	-	I	-	-	-	CoA enzyme activase uncharacterised domain (DUF2229)
MHALACOG_00192	0.0	egtA	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Glutamate-cysteine ligase family 2(GCS2)
MHALACOG_00193	3.05e-169	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_00194	0.0	bgl2	3.2.1.21	GH3	G	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Fibronectin type III-like domain
MHALACOG_00195	3.08e-45	-	-	-	L	-	-	-	Transposase DDE domain
MHALACOG_00196	7.78e-56	-	-	-	L	-	-	-	Transposase
MHALACOG_00197	4.93e-247	-	-	-	I	-	-	-	Hydrolase, alpha beta domain protein
MHALACOG_00198	0.0	amyE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_00199	6.98e-182	-	3.4.13.22	-	S	ko:K08641,ko:K11206	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
MHALACOG_00200	5.16e-135	gat	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Amidase
MHALACOG_00201	1.35e-41	-	-	-	O	-	-	-	OsmC-like protein
MHALACOG_00202	1.02e-176	-	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding protein domain
MHALACOG_00203	5.37e-269	-	-	-	U	ko:K06610	-	ko00000,ko02000	Sugar (and other) transporter
MHALACOG_00204	0.0	-	3.2.1.40	-	E	ko:K05989	-	ko00000,ko01000	Bacterial alpha-L-rhamnosidase C-terminal domain
MHALACOG_00205	7.39e-256	-	-	-	G	-	-	-	Transporter major facilitator family protein
MHALACOG_00206	2.63e-89	mgtC	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
MHALACOG_00207	7.12e-62	-	-	-	S	-	-	-	Nucleotidyltransferase domain
MHALACOG_00208	7.61e-93	-	-	-	S	-	-	-	Nucleotidyltransferase substrate binding protein like
MHALACOG_00209	1.19e-302	-	3.2.1.4, 3.2.1.58	GH5,GH9	G	ko:K01179,ko:K01210	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MHALACOG_00210	1.05e-48	-	-	-	-	-	-	-	-
MHALACOG_00211	3.26e-94	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_00212	1.16e-205	-	-	-	G	-	-	-	Major Facilitator Superfamily
MHALACOG_00213	3.64e-309	-	-	-	S	ko:K06978	-	ko00000	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
MHALACOG_00214	4.13e-141	-	-	-	I	-	-	-	Hydrolase, alpha beta domain protein
MHALACOG_00215	9.78e-111	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_00216	0.0	bglB	3.2.1.21	GH3	G	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Glycosyl hydrolase family 3 N-terminal domain protein
MHALACOG_00217	1.73e-108	-	-	-	K	-	-	-	MarR family
MHALACOG_00218	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
MHALACOG_00219	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter transmembrane region
MHALACOG_00220	0.0	-	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MHALACOG_00221	4.18e-131	-	-	-	T	ko:K16923	-	ko00000,ko00002,ko02000	ECF transporter, substrate-specific component
MHALACOG_00222	2.25e-175	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
MHALACOG_00223	3.54e-191	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00224	2.4e-191	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00225	6.06e-150	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	N-(5'phosphoribosyl)anthranilate (PRA) isomerase
MHALACOG_00226	9.31e-224	-	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	pfkB family carbohydrate kinase
MHALACOG_00227	4.54e-240	rihB	3.2.2.1, 3.2.2.8	-	F	ko:K01239,ko:K01250,ko:K10213	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
MHALACOG_00228	1.98e-164	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
MHALACOG_00229	4.93e-286	bdhA	-	-	C	ko:K19955	-	ko00000,ko01000	Iron-containing alcohol dehydrogenase
MHALACOG_00230	1.92e-207	rbsK	2.7.1.15	-	G	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MHALACOG_00231	0.0	-	-	-	EGP	ko:K08168	-	ko00000,ko00002,ko01504,ko02000	Major Facilitator Superfamily
MHALACOG_00232	4.1e-227	-	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
MHALACOG_00233	3.38e-146	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Psort location Cytoplasmic, score 8.87
MHALACOG_00234	1.16e-310	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I II
MHALACOG_00235	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MHALACOG_00237	0.0	-	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
MHALACOG_00238	5.47e-307	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	HsdM N-terminal domain
MHALACOG_00239	1.13e-91	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
MHALACOG_00240	1.81e-68	-	-	-	V	-	-	-	Type I restriction modification DNA specificity domain protein
MHALACOG_00241	5.98e-134	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
MHALACOG_00242	1.13e-35	-	3.1.21.3	-	L	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
MHALACOG_00243	1.87e-288	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MHALACOG_00244	1.9e-61	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MHALACOG_00245	0.0	ilvD	4.2.1.9	-	H	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the IlvD Edd family
MHALACOG_00246	4.84e-231	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MHALACOG_00247	2.14e-171	-	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
MHALACOG_00248	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MHALACOG_00249	1.74e-164	serB	3.1.3.3	-	E	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01009	haloacid dehalogenase-like hydrolase
MHALACOG_00250	3.15e-163	-	-	-	S	-	-	-	SNARE associated Golgi protein
MHALACOG_00251	0.0	arc	-	-	O	ko:K13527	ko03050,map03050	ko00000,ko00001,ko00002,ko03051	AAA ATPase forming ring-shaped complexes
MHALACOG_00252	0.0	dop	3.5.1.119	-	S	ko:K20814	-	ko00000,ko01000,ko03051	Pup-ligase protein
MHALACOG_00253	5.4e-222	-	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase family
MHALACOG_00254	1.43e-26	pup	-	-	S	ko:K13570	-	ko00000,ko04121	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation
MHALACOG_00255	0.0	pafA	6.3.1.19	-	O	ko:K13571	-	ko00000,ko00002,ko01000,ko03051	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MHALACOG_00256	3.31e-57	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Belongs to the bacterial histone-like protein family
MHALACOG_00257	0.0	-	-	-	S	-	-	-	Lysylphosphatidylglycerol synthase TM region
MHALACOG_00258	0.0	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminal
MHALACOG_00259	1.55e-140	-	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
MHALACOG_00261	0.0	-	-	-	S	-	-	-	PGAP1-like protein
MHALACOG_00262	2.21e-68	-	-	-	-	-	-	-	-
MHALACOG_00263	7.41e-88	-	-	-	-	-	-	-	-
MHALACOG_00264	6.45e-223	-	-	-	S	ko:K07114	-	ko00000,ko02000	von Willebrand factor (vWF) type A domain
MHALACOG_00265	1.11e-239	-	-	-	S	ko:K07114	-	ko00000,ko02000	von Willebrand factor (vWF) type A domain
MHALACOG_00266	1.05e-116	-	-	-	-	-	-	-	-
MHALACOG_00267	3.63e-220	-	-	-	S	-	-	-	Protein of unknown function DUF58
MHALACOG_00268	9.64e-249	moxR	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
MHALACOG_00269	5.7e-169	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MHALACOG_00270	4.23e-95	-	-	-	S	-	-	-	LytR cell envelope-related transcriptional attenuator
MHALACOG_00271	2.18e-51	cspA	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
MHALACOG_00272	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MHALACOG_00273	2.78e-55	-	-	-	S	-	-	-	Proteins of 100 residues with WXG
MHALACOG_00274	3.67e-108	-	-	-	-	-	-	-	-
MHALACOG_00275	6.47e-170	phoP	-	-	KT	ko:K02483	-	ko00000,ko02022	Response regulator receiver domain protein
MHALACOG_00276	0.0	phoR	2.7.13.3	-	T	ko:K02484	-	ko00000,ko01000,ko01001,ko02022	ATPase histidine kinase DNA gyrase B HSP90 domain protein
MHALACOG_00277	2.49e-87	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
MHALACOG_00278	8.88e-254	-	-	-	S	-	-	-	Protein of unknown function (DUF3027)
MHALACOG_00279	5.83e-224	uspA	-	-	T	-	-	-	Belongs to the universal stress protein A family
MHALACOG_00280	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	ATPase family associated with various cellular activities (AAA)
MHALACOG_00281	0.0	codA	3.5.4.1, 3.5.4.21	-	F	ko:K01485,ko:K03365	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
MHALACOG_00282	0.0	-	-	-	QT	-	-	-	Purine catabolism regulatory protein-like family
MHALACOG_00283	1.82e-316	proP	-	-	EGP	ko:K03762	-	ko00000,ko02000	Sugar (and other) transporter
MHALACOG_00284	2.39e-177	-	3.5.2.10	-	S	ko:K01470	ko00330,map00330	ko00000,ko00001,ko01000	Creatinine amidohydrolase
MHALACOG_00285	0.0	-	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	5'-nucleotidase, C-terminal domain
MHALACOG_00286	2.21e-300	-	-	-	S	-	-	-	Domain of Unknown Function (DUF349)
MHALACOG_00287	0.0	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Histidyl-tRNA synthetase
MHALACOG_00288	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MHALACOG_00289	6.14e-233	-	-	-	S	-	-	-	Protein of unknown function (DUF559)
MHALACOG_00290	1.36e-181	gluA	-	-	E	ko:K10008	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding protein of ABC transporter for glutamate K02028
MHALACOG_00291	5.91e-196	gluB	-	-	ET	ko:K10005	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MHALACOG_00292	1.41e-142	gluC	-	-	E	ko:K10006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00293	1.89e-238	gluD	-	-	E	ko:K10007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00294	0.0	-	-	-	I	-	-	-	PAP2 superfamily
MHALACOG_00295	2.58e-55	-	-	-	T	-	-	-	Pfam Adenylate and Guanylate cyclase catalytic domain
MHALACOG_00296	1.94e-247	-	-	-	S	-	-	-	Polyphosphate kinase 2 (PPK2)
MHALACOG_00297	0.0	-	-	-	L	-	-	-	DEAD DEAH box helicase
MHALACOG_00298	0.0	rarA	-	-	L	ko:K07478	-	ko00000	Recombination factor protein RarA
MHALACOG_00299	5.87e-147	mtrA	-	-	KT	ko:K07670	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
MHALACOG_00300	0.0	mtrB	2.7.13.3	-	T	ko:K07636,ko:K07654	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MHALACOG_00301	0.0	lpqB	-	-	S	-	-	-	Lipoprotein LpqB beta-propeller domain
MHALACOG_00302	1.75e-228	-	-	-	G	ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein domain
MHALACOG_00303	0.0	-	3.6.3.17	-	G	ko:K02056,ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00304	1.8e-231	ytfT	-	-	U	ko:K02057,ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
MHALACOG_00305	1.99e-220	-	-	-	U	ko:K02057,ko:K10440,ko:K17209	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
MHALACOG_00306	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MHALACOG_00307	1.57e-236	-	-	-	EH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
MHALACOG_00308	2.98e-75	-	-	-	-	-	-	-	-
MHALACOG_00309	1.15e-103	-	-	-	J	-	-	-	TM2 domain
MHALACOG_00310	2.46e-72	-	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
MHALACOG_00311	3.84e-62	-	-	-	J	ko:K07574	-	ko00000,ko03009	CRS1_YhbY
MHALACOG_00312	0.0	-	-	-	GP	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MHALACOG_00313	1.31e-134	-	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MHALACOG_00314	7.42e-257	-	-	-	S	-	-	-	Glycosyltransferase, group 2 family protein
MHALACOG_00315	1.13e-171	-	-	-	C	-	-	-	Putative TM nitroreductase
MHALACOG_00316	1.9e-180	ppgK	2.7.1.2, 2.7.1.63	-	GK	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
MHALACOG_00317	3.35e-289	-	-	-	E	-	-	-	Aminotransferase class I and II
MHALACOG_00318	1.28e-173	-	-	-	P	ko:K16784	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00319	1e-41	-	2.8.2.22	-	S	ko:K01023	-	ko00000,ko01000	Arylsulfotransferase Ig-like domain
MHALACOG_00320	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MHALACOG_00321	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
MHALACOG_00322	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MHALACOG_00323	7.47e-259	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MHALACOG_00324	6.45e-203	-	-	-	S	-	-	-	Protein conserved in bacteria
MHALACOG_00325	1.08e-175	-	-	-	U	ko:K17331	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00326	0.0	-	-	-	G	-	-	-	Glycosyl hydrolase family 20, domain 2
MHALACOG_00327	6.09e-54	-	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_00328	0.0	-	3.2.1.177	GH31	G	ko:K01811	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 31 family
MHALACOG_00329	1.08e-217	-	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
MHALACOG_00330	2.9e-11	-	-	-	G	-	-	-	Domain of unknown function (DUF4432)
MHALACOG_00331	2.26e-68	-	-	-	G	-	-	-	Domain of unknown function (DUF4432)
MHALACOG_00332	3.87e-77	tam	2.1.1.144	-	S	ko:K00598	-	ko00000,ko01000	Methyltransferase domain
MHALACOG_00333	2.5e-79	tam	2.1.1.144	-	S	ko:K00598	-	ko00000,ko01000	Methyltransferase domain
MHALACOG_00334	5.87e-43	-	-	-	-	-	-	-	-
MHALACOG_00335	6.58e-81	-	-	-	M	-	-	-	L,D-transpeptidase catalytic domain
MHALACOG_00336	3.16e-163	-	-	-	V	ko:K02069	-	ko00000,ko00002,ko02000	Uncharacterised protein family (UPF0014)
MHALACOG_00337	1.02e-143	-	-	-	V	ko:K02068	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00338	7.09e-136	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MHALACOG_00339	5.27e-111	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MHALACOG_00340	2.08e-306	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarA family
MHALACOG_00341	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
MHALACOG_00342	1.65e-211	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
MHALACOG_00343	1.53e-134	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
MHALACOG_00344	1.9e-170	-	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Exonuclease, DNA polymerase III, epsilon subunit family
MHALACOG_00345	0.0	tetM	-	-	J	ko:K18220	-	br01600,ko00000,ko01504	Elongation factor G, domain IV
MHALACOG_00346	2.6e-155	-	-	-	S	ko:K06999	-	ko00000	Phospholipase/Carboxylesterase
MHALACOG_00347	6.62e-166	istB	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_00348	0.0	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00349	2.73e-283	metC1	4.4.1.8	-	E	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Cys/Met metabolism PLP-dependent enzyme
MHALACOG_00350	1.86e-267	-	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
MHALACOG_00351	5.01e-47	-	-	-	O	-	-	-	Glutaredoxin
MHALACOG_00352	1.19e-177	ehuA	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00353	4.62e-184	-	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Bacterial periplasmic substrate-binding proteins
MHALACOG_00354	2.37e-143	tcyA/tcyB	-	-	E	ko:K02029,ko:K02424,ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Binding-protein-dependent transport system inner membrane component
MHALACOG_00355	4.74e-172	hflK	-	-	O	-	-	-	prohibitin homologues
MHALACOG_00356	8.71e-197	-	-	-	S	-	-	-	Patatin-like phospholipase
MHALACOG_00357	1.23e-185	murI	5.1.1.3	-	M	ko:K01776	ko00471,ko01100,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
MHALACOG_00358	1.21e-213	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine
MHALACOG_00359	2.01e-161	-	-	-	S	-	-	-	Vitamin K epoxide reductase
MHALACOG_00360	1.48e-214	PPA1328	3.1.3.97, 3.1.4.57	-	S	ko:K07053,ko:K20859	ko00440,map00440	ko00000,ko00001,ko01000	DNA polymerase alpha chain like domain
MHALACOG_00361	4.61e-44	-	-	-	S	-	-	-	Protein of unknown function (DUF3107)
MHALACOG_00362	0.0	mphA	-	-	S	-	-	-	Aminoglycoside phosphotransferase
MHALACOG_00363	0.0	uvrD2	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MHALACOG_00364	0.0	-	-	-	S	-	-	-	Zincin-like metallopeptidase
MHALACOG_00365	2.81e-201	sdrC	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
MHALACOG_00366	2.15e-65	-	-	-	S	-	-	-	Protein of unknown function (DUF3052)
MHALACOG_00368	0.0	-	-	-	NU	-	-	-	Tfp pilus assembly protein FimV
MHALACOG_00369	1.28e-274	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MHALACOG_00370	1.38e-295	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MHALACOG_00371	0.0	-	-	-	I	-	-	-	acetylesterase activity
MHALACOG_00372	3.8e-163	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
MHALACOG_00373	8.49e-197	uppS	2.5.1.31, 2.5.1.86, 2.5.1.88	-	H	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MHALACOG_00374	4.36e-274	-	-	-	F	-	-	-	nucleoside hydrolase
MHALACOG_00375	0.0	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00376	8.08e-260	-	-	-	P	-	-	-	NMT1/THI5 like
MHALACOG_00377	7.99e-180	-	-	-	P	-	-	-	Binding-protein-dependent transport system inner membrane component
MHALACOG_00378	0.0	fosC	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
MHALACOG_00379	1.14e-282	lacY	-	-	P	ko:K02532	-	ko00000,ko02000	LacY proton/sugar symporter
MHALACOG_00380	9.88e-240	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MHALACOG_00381	8.71e-317	-	-	-	O	ko:K13963	ko05146,map05146	ko00000,ko00001	SERine Proteinase INhibitors
MHALACOG_00382	5.17e-83	-	-	-	-	-	-	-	-
MHALACOG_00383	2.27e-16	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00384	6.87e-311	-	-	-	G	ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
MHALACOG_00385	3.87e-80	-	-	-	S	-	-	-	Thiamine-binding protein
MHALACOG_00386	1.02e-185	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
MHALACOG_00387	1.22e-41	-	-	-	O	ko:K13525	ko04141,ko05134,map04141,map05134	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	AAA domain (Cdc48 subfamily)
MHALACOG_00388	0.0	thiC	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MHALACOG_00389	2.62e-212	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MHALACOG_00390	0.0	glyQS	6.1.1.14	-	J	ko:K01880	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of glycine to tRNA(Gly)
MHALACOG_00391	8.47e-302	dus	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MHALACOG_00392	5.11e-243	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MHALACOG_00393	2.38e-104	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MHALACOG_00394	1.64e-58	-	-	-	S	ko:K02221	-	ko00000,ko02044	YGGT family
MHALACOG_00395	6.48e-132	-	-	-	V	-	-	-	DivIVA protein
MHALACOG_00396	2.99e-116	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MHALACOG_00397	1.32e-224	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
MHALACOG_00398	1.38e-159	-	-	-	S	ko:K07058	-	ko00000	Virulence factor BrkB
MHALACOG_00399	2.3e-49	-	-	-	-	-	-	-	-
MHALACOG_00400	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III alpha subunit
MHALACOG_00401	1.11e-95	-	-	-	S	-	-	-	Domain of unknown function (DUF4186)
MHALACOG_00402	0.0	-	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	MCRA family
MHALACOG_00403	1.53e-117	-	-	-	K	-	-	-	acetyltransferase
MHALACOG_00404	4.16e-194	-	-	-	S	-	-	-	Aldo/keto reductase family
MHALACOG_00405	0.0	-	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	FGGY family of carbohydrate kinases, N-terminal domain
MHALACOG_00406	1.22e-54	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Acylphosphatase
MHALACOG_00407	0.0	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MHALACOG_00408	3.85e-280	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MHALACOG_00409	1.66e-144	hisB	3.1.3.15, 4.2.1.19	-	E	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Imidazoleglycerol-phosphate dehydratase
MHALACOG_00410	7.99e-150	-	-	-	-	-	-	-	-
MHALACOG_00411	8.43e-155	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MHALACOG_00412	7.98e-166	hisA	5.3.1.16, 5.3.1.24	-	E	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Histidine biosynthesis protein
MHALACOG_00413	0.0	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2252)
MHALACOG_00414	0.0	glnA2	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
MHALACOG_00415	4.33e-94	-	-	-	EGP	ko:K18567,ko:K19577	-	ko00000,ko02000	Major Facilitator Superfamily
MHALACOG_00416	9.47e-180	-	-	-	M	-	-	-	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MHALACOG_00417	0.0	hrpA	3.6.4.13	-	L	ko:K03578	-	ko00000,ko01000	Helicase associated domain (HA2) Add an annotation
MHALACOG_00418	1.11e-156	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase (PrmA)
MHALACOG_00419	0.0	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MHALACOG_00420	5.62e-226	ldh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
MHALACOG_00421	1.48e-201	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MHALACOG_00422	2.78e-166	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MHALACOG_00423	2.42e-72	-	-	-	M	-	-	-	Lysin motif
MHALACOG_00424	2.16e-64	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MHALACOG_00425	1.13e-290	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
MHALACOG_00426	0.0	-	-	-	L	-	-	-	DNA helicase
MHALACOG_00427	4.7e-120	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
MHALACOG_00428	7.92e-248	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MHALACOG_00429	1.85e-94	-	-	-	D	-	-	-	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MHALACOG_00430	0.0	ftsI	3.4.16.4	-	M	ko:K03587	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011,ko03036	Penicillin-binding protein, transpeptidase domain protein
MHALACOG_00431	2.79e-195	-	-	-	M	-	-	-	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MHALACOG_00432	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MHALACOG_00433	5.29e-262	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MHALACOG_00434	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MHALACOG_00435	6.18e-282	ftsW	2.4.1.227	GT28	D	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	Belongs to the SEDS family
MHALACOG_00436	1.4e-281	murG	2.4.1.227, 6.3.2.8	GT28	M	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MHALACOG_00437	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
MHALACOG_00438	4.23e-229	ftsQ	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein FtsQ
MHALACOG_00440	1.42e-32	-	-	-	S	-	-	-	Putative phage holin Dp-1
MHALACOG_00441	3.48e-74	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
MHALACOG_00442	2.03e-22	-	-	-	-	-	-	-	-
MHALACOG_00447	7.3e-314	-	-	-	S	-	-	-	cellulase activity
MHALACOG_00448	6.59e-07	-	-	-	S	-	-	-	cellulase activity
MHALACOG_00449	2.11e-101	-	-	-	NT	-	-	-	phage tail tape measure protein
MHALACOG_00451	1.88e-37	-	-	-	-	-	-	-	-
MHALACOG_00452	0.000954	ligA1	-	-	N	-	-	-	Bacterial Ig-like domain 2
MHALACOG_00453	1.35e-58	-	-	-	-	-	-	-	-
MHALACOG_00454	3.92e-41	-	-	-	-	-	-	-	-
MHALACOG_00455	6.13e-33	-	-	-	-	-	-	-	-
MHALACOG_00456	1.65e-40	-	-	-	-	-	-	-	-
MHALACOG_00457	6.34e-25	-	-	-	-	-	-	-	-
MHALACOG_00459	9.92e-98	-	-	-	S	-	-	-	Phage capsid family
MHALACOG_00460	7.3e-38	-	-	-	S	ko:K06904	-	ko00000	Caudovirus prohead serine protease
MHALACOG_00461	3.16e-97	-	-	-	S	-	-	-	Phage portal protein
MHALACOG_00462	0.0	-	-	-	S	-	-	-	Terminase
MHALACOG_00463	1.98e-49	-	-	-	-	-	-	-	-
MHALACOG_00466	6.1e-37	-	-	-	K	-	-	-	Transcriptional regulator
MHALACOG_00470	1.84e-117	-	-	-	-	-	-	-	-
MHALACOG_00477	2.53e-13	-	-	-	-	-	-	-	-
MHALACOG_00485	4.85e-35	-	-	-	-	-	-	-	-
MHALACOG_00486	3.41e-58	-	-	-	-	-	-	-	-
MHALACOG_00488	2.3e-84	-	-	-	-	-	-	-	-
MHALACOG_00491	2.32e-107	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
MHALACOG_00492	1.57e-165	-	-	-	L	-	-	-	YqaJ-like viral recombinase domain
MHALACOG_00498	1.71e-61	-	-	-	-	-	-	-	-
MHALACOG_00500	9.22e-06	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
MHALACOG_00501	7.76e-256	tnp3503b	-	-	L	-	-	-	Transposase and inactivated derivatives
MHALACOG_00502	1.6e-158	int8	-	-	L	-	-	-	Phage integrase family
MHALACOG_00503	4.41e-161	lppD	-	-	S	-	-	-	Appr-1'-p processing enzyme
MHALACOG_00504	1.59e-107	-	-	-	S	-	-	-	von Willebrand factor (vWF) type A domain
MHALACOG_00505	3.5e-112	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MHALACOG_00506	0.0	-	3.2.1.24	GH38	G	ko:K01191	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
MHALACOG_00507	0.0	-	3.2.1.24	GH38	G	ko:K01191	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
MHALACOG_00508	1.93e-316	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_00509	2.49e-210	-	-	-	G	ko:K02025,ko:K17330	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00510	1.84e-199	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00511	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MHALACOG_00512	0.0	-	3.2.1.21	GH3	G	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Glycosyl hydrolase family 3 C-terminal domain
MHALACOG_00513	0.0	-	-	-	G	-	-	-	Glycosyl hydrolase family 85
MHALACOG_00514	8.57e-234	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_00515	4.78e-314	-	-	-	G	-	-	-	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
MHALACOG_00516	0.0	-	-	-	S	ko:K09704	-	ko00000	Metal-independent alpha-mannosidase (GH125)
MHALACOG_00517	6.42e-21	fucP	-	-	G	ko:K02429	-	ko00000,ko02000	Major Facilitator Superfamily
MHALACOG_00518	7.66e-14	fucP	-	-	G	ko:K02429	-	ko00000,ko02000	Major Facilitator Superfamily
MHALACOG_00519	6.59e-92	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MHALACOG_00520	2.36e-216	-	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
MHALACOG_00521	5.24e-278	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
MHALACOG_00522	8.15e-211	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
MHALACOG_00523	1.12e-266	-	-	-	GK	-	-	-	ROK family
MHALACOG_00524	1.34e-192	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MHALACOG_00525	8.5e-302	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Amidohydrolase family
MHALACOG_00526	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
MHALACOG_00527	3.69e-239	dppB	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00528	1.13e-253	dppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00529	0.0	-	-	-	P	ko:K02031,ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MHALACOG_00530	2.16e-125	-	-	-	F	-	-	-	NUDIX domain
MHALACOG_00531	0.0	pepP	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Aminopeptidase P, N-terminal domain
MHALACOG_00532	2.18e-136	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_00533	0.0	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Mur ligase middle domain
MHALACOG_00534	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
MHALACOG_00535	1.85e-241	-	-	-	V	-	-	-	Acetyltransferase (GNAT) domain
MHALACOG_00536	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MHALACOG_00537	4.71e-167	sigH	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MHALACOG_00538	2.25e-70	-	-	-	-	-	-	-	-
MHALACOG_00539	2.93e-234	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
MHALACOG_00540	5.52e-241	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
MHALACOG_00541	4.11e-229	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MHALACOG_00542	1.85e-115	ybaK	-	-	J	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MHALACOG_00543	2.89e-251	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MHALACOG_00544	2.7e-173	-	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Thiamin pyrophosphokinase, vitamin B1 binding domain
MHALACOG_00545	3.24e-186	-	-	-	S	-	-	-	Spermine/spermidine synthase domain
MHALACOG_00546	3.43e-111	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MHALACOG_00547	1.4e-36	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L35
MHALACOG_00548	1.57e-80	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MHALACOG_00549	1.94e-214	xerD	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	recombinase XerD
MHALACOG_00550	0.0	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00551	2.98e-192	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	CobQ CobB MinD ParA nucleotide binding domain protein
MHALACOG_00552	3.55e-205	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MHALACOG_00553	5.59e-160	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MHALACOG_00554	3.18e-198	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX hydrolase
MHALACOG_00555	9.76e-317	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MHALACOG_00556	0.0	nadB	1.4.3.16, 2.4.2.19	-	H	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
MHALACOG_00557	1.85e-208	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate phosphoribosyl transferase, N-terminal domain
MHALACOG_00558	2.14e-278	iscS1	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class-V
MHALACOG_00559	3.29e-313	nanT	-	-	U	ko:K03290,ko:K08178,ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
MHALACOG_00560	0.0	typA	-	-	T	ko:K06207	-	ko00000	Elongation factor G C-terminus
MHALACOG_00561	9.21e-99	-	-	-	-	-	-	-	-
MHALACOG_00562	5.47e-237	pheA	4.2.1.51, 5.4.99.5	-	E	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
MHALACOG_00563	2.54e-244	tyrA	1.3.1.12	-	E	ko:K00210,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydrogenase
MHALACOG_00564	3.75e-57	-	-	-	-	-	-	-	-
MHALACOG_00565	1.44e-232	xerC	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family. XerC subfamily
MHALACOG_00566	0.0	dppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
MHALACOG_00567	4.64e-203	dppB	-	-	EP	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00568	3.14e-230	dppC	-	-	EP	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
MHALACOG_00569	0.0	-	-	-	EP	ko:K02031,ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
MHALACOG_00570	6.27e-215	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease/Exonuclease/phosphatase family
MHALACOG_00571	1.93e-183	-	-	-	S	-	-	-	Protein of unknown function (DUF3710)
MHALACOG_00572	5.27e-169	-	-	-	S	-	-	-	Protein of unknown function (DUF3159)
MHALACOG_00573	2.11e-309	rumA	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MHALACOG_00574	1.79e-148	-	-	-	-	-	-	-	-
MHALACOG_00575	0.0	ctpE	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
MHALACOG_00576	0.0	acnA	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MHALACOG_00577	7.15e-65	-	-	-	L	-	-	-	RelB antitoxin
MHALACOG_00578	5.4e-37	-	-	-	S	-	-	-	PIN domain
MHALACOG_00579	0.0	-	-	-	S	-	-	-	Protein of unknown function DUF262
MHALACOG_00580	6.37e-124	-	-	-	E	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00581	4.67e-121	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00582	6.97e-214	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00583	1.85e-62	-	-	-	S	-	-	-	Domain of unknown function (DUF5067)
MHALACOG_00584	3.64e-182	-	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
MHALACOG_00585	8.1e-219	-	-	-	EG	-	-	-	EamA-like transporter family
MHALACOG_00586	4.61e-172	ywaC	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	Region found in RelA / SpoT proteins
MHALACOG_00587	0.0	miaB	2.8.4.3	-	H	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MHALACOG_00588	2.24e-236	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MHALACOG_00589	2.27e-174	fic	-	-	D	ko:K04095	-	ko00000,ko03036	Fic/DOC family
MHALACOG_00590	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	FtsK SpoIIIE family protein
MHALACOG_00591	2.79e-150	pgsA	2.7.8.41, 2.7.8.5	-	I	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MHALACOG_00592	7.14e-117	cinA	3.5.1.42	-	S	ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
MHALACOG_00593	2.49e-105	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MHALACOG_00594	1.89e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF3046)
MHALACOG_00595	2.5e-261	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MHALACOG_00596	1.41e-135	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
MHALACOG_00598	1.24e-154	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MHALACOG_00599	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MHALACOG_00600	7.22e-75	-	-	-	L	ko:K07485	-	ko00000	Transposase
MHALACOG_00601	4.17e-23	-	-	-	L	ko:K07485	-	ko00000	Transposase
MHALACOG_00602	3.76e-245	trpD	2.4.2.18	-	F	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MHALACOG_00603	1.44e-138	-	-	-	-	-	-	-	-
MHALACOG_00604	4.85e-168	plsC2	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Phosphate acyltransferases
MHALACOG_00605	0.0	pknL	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	PASTA
MHALACOG_00606	2.35e-245	idsA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
MHALACOG_00607	2.71e-158	-	-	-	-	-	-	-	-
MHALACOG_00608	1.37e-253	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MHALACOG_00609	0.0	gyrB2	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	DNA topoisomerase (ATP-hydrolyzing)
MHALACOG_00610	1.71e-263	-	-	-	G	-	-	-	Major Facilitator Superfamily
MHALACOG_00611	2.8e-217	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MHALACOG_00612	0.0	lhr	-	-	L	ko:K03724	-	ko00000,ko01000,ko03400	DEAD DEAH box helicase
MHALACOG_00613	6.75e-157	-	-	-	KT	-	-	-	RESPONSE REGULATOR receiver
MHALACOG_00614	0.0	gyrA2	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	DNA topoisomerase (ATP-hydrolyzing)
MHALACOG_00615	2.04e-296	-	-	-	S	-	-	-	Type I phosphodiesterase / nucleotide pyrophosphatase
MHALACOG_00616	4.27e-222	-	-	-	S	-	-	-	Protein of unknown function (DUF3071)
MHALACOG_00617	3.36e-61	-	-	-	S	-	-	-	Domain of unknown function (DUF4193)
MHALACOG_00618	3.4e-108	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
MHALACOG_00619	0.0	relA	2.7.6.5, 3.1.7.2	-	KT	ko:K00951,ko:K01139	ko00230,map00230	ko00000,ko00001,ko01000,ko03009	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MHALACOG_00620	8.17e-174	-	-	-	L	ko:K07497	-	ko00000	Integrase core domain
MHALACOG_00621	2.11e-73	-	-	-	L	-	-	-	Helix-turn-helix domain
MHALACOG_00622	9.99e-132	ppiA	5.2.1.8	-	G	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	ko00000,ko00001,ko01000,ko03110,ko04147	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MHALACOG_00623	2.11e-61	-	-	-	-	-	-	-	-
MHALACOG_00624	6.48e-216	-	-	-	EG	-	-	-	EamA-like transporter family
MHALACOG_00625	2.35e-92	pdxH	-	-	S	ko:K07006	-	ko00000	Pfam:Pyridox_oxidase
MHALACOG_00626	6.07e-310	-	-	-	L	-	-	-	ribosomal rna small subunit methyltransferase
MHALACOG_00627	9.22e-210	gpmB	3.1.3.85, 5.4.2.11	-	G	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Phosphoglycerate mutase family
MHALACOG_00628	7.02e-218	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
MHALACOG_00629	2.78e-193	-	-	-	ET	ko:K10005	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
MHALACOG_00630	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
MHALACOG_00631	7.41e-99	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Helix-hairpin-helix motif
MHALACOG_00632	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein
MHALACOG_00633	3.91e-224	-	-	-	Q	-	-	-	Amidohydrolase family
MHALACOG_00634	7.1e-226	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
MHALACOG_00635	1.8e-129	tsaE	-	-	S	ko:K06925	-	ko00000,ko03016	Threonylcarbamoyl adenosine biosynthesis protein TsaE
MHALACOG_00636	3.6e-188	yeaZ	-	-	O	ko:K14742	-	ko00000,ko03016	Glycoprotease family
MHALACOG_00637	5.47e-121	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	FR47-like protein
MHALACOG_00638	1.32e-249	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MHALACOG_00642	1.06e-139	-	-	-	M	-	-	-	Peptidase family M23
MHALACOG_00643	0.0	-	-	-	G	-	-	-	ABC transporter substrate-binding protein
MHALACOG_00644	1.65e-307	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the isocitrate and isopropylmalate dehydrogenases family
MHALACOG_00645	4.56e-266	guaB3	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	IMP dehydrogenase family protein
MHALACOG_00646	1.63e-90	-	-	-	-	-	-	-	-
MHALACOG_00647	0.0	fadD3	6.2.1.3	-	I	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	long-chain-fatty acid CoA ligase
MHALACOG_00648	4.26e-113	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MHALACOG_00649	2.88e-188	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
MHALACOG_00650	1.95e-187	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MHALACOG_00651	1.49e-168	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
MHALACOG_00652	2.46e-120	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MHALACOG_00653	4.37e-218	cdsA	2.7.7.41	-	I	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Cytidylyltransferase family
MHALACOG_00654	2.16e-283	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MHALACOG_00655	1.23e-124	-	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
MHALACOG_00656	9.73e-179	hisF	4.1.3.27	-	E	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MHALACOG_00657	1.05e-89	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MHALACOG_00658	0.0	trpE	4.1.3.27	-	E	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MHALACOG_00659	1.97e-13	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MHALACOG_00660	0.0	ybiT	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
MHALACOG_00661	8.96e-160	-	-	-	S	-	-	-	Enoyl-(Acyl carrier protein) reductase
MHALACOG_00662	1.87e-81	-	-	-	S	-	-	-	Zincin-like metallopeptidase
MHALACOG_00663	7.73e-116	-	-	-	G	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00664	7.85e-261	-	-	-	G	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00665	3.23e-128	-	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
MHALACOG_00666	7.7e-121	-	-	-	S	ko:K16926	-	ko00000,ko00002,ko02000	Hypothetical bacterial integral membrane protein (Trep_Strep)
MHALACOG_00667	0.0	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00668	1.28e-142	-	-	-	S	-	-	-	Domain of unknown function (DUF4194)
MHALACOG_00669	0.0	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00670	1.81e-181	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00671	1.05e-49	-	-	-	-	-	-	-	-
MHALACOG_00672	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MHALACOG_00673	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MHALACOG_00674	1.02e-234	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Shikimate dehydrogenase substrate binding domain
MHALACOG_00675	1.69e-231	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
MHALACOG_00676	9.97e-218	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
MHALACOG_00677	2.15e-280	pgk	2.7.2.3, 5.3.1.1	-	F	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglycerate kinase
MHALACOG_00678	9.38e-187	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MHALACOG_00679	2.51e-47	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase SecG subunit
MHALACOG_00680	3.79e-222	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
MHALACOG_00681	3.61e-208	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
MHALACOG_00682	0.0	aspC	2.6.1.1, 2.6.1.2, 2.6.1.66	-	E	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I II
MHALACOG_00684	8.06e-154	-	-	-	-	-	-	-	-
MHALACOG_00685	1.89e-294	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
MHALACOG_00686	2.04e-254	tal	2.2.1.2	-	H	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MHALACOG_00687	0.0	tkt	2.2.1.1	-	H	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the transketolase family
MHALACOG_00688	1.23e-237	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MHALACOG_00689	4.43e-272	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MHALACOG_00690	3.59e-198	-	-	-	G	-	-	-	Fructosamine kinase
MHALACOG_00691	3.7e-202	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MHALACOG_00692	2.47e-205	-	-	-	S	-	-	-	PAC2 family
MHALACOG_00698	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MHALACOG_00699	3.23e-144	-	2.7.7.53	-	FG	ko:K19710	ko00230,map00230	ko00000,ko00001,ko01000	HIT domain
MHALACOG_00700	2.04e-173	yebC	-	-	K	-	-	-	transcriptional regulatory protein
MHALACOG_00701	1.72e-130	ruvC	3.1.22.4	-	L	ko:K01159	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MHALACOG_00702	6.14e-140	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MHALACOG_00703	5.84e-252	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MHALACOG_00704	6.51e-71	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit
MHALACOG_00705	1.71e-125	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MHALACOG_00706	4.88e-281	sucC	6.2.1.5	-	F	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MHALACOG_00707	2.52e-209	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MHALACOG_00708	2.34e-302	-	-	-	-	-	-	-	-
MHALACOG_00709	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
MHALACOG_00710	5.89e-42	-	-	-	-	-	-	-	-
MHALACOG_00711	2.11e-206	-	-	-	U	ko:K06188	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
MHALACOG_00712	5.46e-185	rluB	5.4.99.19, 5.4.99.22	-	J	ko:K06178,ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
MHALACOG_00713	0.0	der	-	-	F	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
MHALACOG_00715	0.0	ugp	2.7.7.9	-	G	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
MHALACOG_00716	0.0	-	-	-	K	-	-	-	WYL domain
MHALACOG_00717	1.59e-65	-	-	-	-	-	-	-	-
MHALACOG_00718	0.0	helY	-	-	L	ko:K03727	-	ko00000,ko01000	DEAD DEAH box helicase
MHALACOG_00719	6.43e-81	rbpA	-	-	K	-	-	-	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters
MHALACOG_00720	6.63e-173	nt5e	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
MHALACOG_00721	4.9e-44	-	-	-	-	-	-	-	-
MHALACOG_00722	2.63e-85	-	-	-	-	-	-	-	-
MHALACOG_00723	6.65e-145	merR2	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MHALACOG_00724	4.07e-97	garA	-	-	T	-	-	-	Inner membrane component of T3SS, cytoplasmic domain
MHALACOG_00725	4.39e-179	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF881)
MHALACOG_00726	7.03e-51	sbp	-	-	S	-	-	-	Protein of unknown function (DUF1290)
MHALACOG_00727	1.47e-203	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF881)
MHALACOG_00728	3.16e-136	pgsA2	2.7.8.41, 2.7.8.5	-	I	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MHALACOG_00729	2.62e-201	hisG	2.4.2.17	-	F	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	ATP phosphoribosyltransferase
MHALACOG_00730	3.56e-56	hisE	3.6.1.31	-	E	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Phosphoribosyl-ATP pyrophosphohydrolase
MHALACOG_00731	6.87e-153	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribulose-phosphate 3-epimerase
MHALACOG_00732	1.2e-238	lgt	-	-	M	-	-	-	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MHALACOG_00733	2.94e-206	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MHALACOG_00734	0.0	trpB	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MHALACOG_00735	3.14e-193	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MHALACOG_00736	1.01e-34	-	-	-	E	ko:K16235	-	ko00000,ko02000	amino acid
MHALACOG_00738	6.97e-240	-	-	-	V	-	-	-	VanZ like family
MHALACOG_00739	7.24e-56	-	-	-	K	-	-	-	Transcriptional regulator, AbiEi antitoxin
MHALACOG_00740	1.89e-52	-	-	-	K	-	-	-	Transcriptional regulator, AbiEi antitoxin
MHALACOG_00741	1.99e-104	-	-	-	S	-	-	-	ASCH
MHALACOG_00742	4.2e-122	-	-	-	K	-	-	-	FR47-like protein
MHALACOG_00743	9.09e-129	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MHALACOG_00744	1.5e-65	-	-	-	-	-	-	-	-
MHALACOG_00745	1.39e-155	-	-	-	-	-	-	-	-
MHALACOG_00748	4.06e-276	-	-	-	L	-	-	-	Transposase, Mutator family
MHALACOG_00749	6.56e-19	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00750	1.91e-260	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00751	3.69e-166	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00752	1.52e-124	-	-	-	-	-	-	-	-
MHALACOG_00753	9.81e-59	-	-	-	M	-	-	-	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MHALACOG_00754	9.14e-263	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_00755	1.16e-131	-	-	-	M	-	-	-	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MHALACOG_00756	7.75e-161	-	-	-	Q	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00757	3.53e-231	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
MHALACOG_00758	1.23e-52	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
MHALACOG_00759	1.3e-64	-	-	-	S	ko:K19157	-	ko00000,ko01000,ko02048	Bacterial toxin of type II toxin-antitoxin system, YafQ
MHALACOG_00760	1.14e-31	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00761	7.96e-44	-	-	-	K	-	-	-	Transcriptional regulator
MHALACOG_00762	5.55e-34	-	-	-	-	-	-	-	-
MHALACOG_00763	1.55e-140	-	-	-	-	-	-	-	-
MHALACOG_00764	2.36e-61	-	-	-	K	ko:K20391	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
MHALACOG_00766	1.32e-45	hipA	2.7.11.1	-	S	ko:K07154	-	ko00000,ko01000,ko01001,ko02048	kinase activity
MHALACOG_00767	4.3e-44	-	-	-	S	-	-	-	Carbon-nitrogen hydrolase
MHALACOG_00768	2.25e-150	-	-	-	F	-	-	-	Hydrolase of X-linked nucleoside diphosphate N terminal
MHALACOG_00769	2.76e-37	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	membrane insertase activity
MHALACOG_00771	9.8e-41	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	membrane insertase activity
MHALACOG_00773	3.09e-109	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MHALACOG_00774	0.0	-	-	-	E	ko:K16235	-	ko00000,ko02000	amino acid
MHALACOG_00775	7.49e-154	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MHALACOG_00776	3.53e-100	-	-	-	-	-	-	-	-
MHALACOG_00777	7.79e-201	-	-	-	-	-	-	-	-
MHALACOG_00778	3.09e-43	-	-	-	S	-	-	-	COGs COG3943 Virulence protein
MHALACOG_00779	3.78e-292	-	2.6.1.1	-	E	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Psort location Cytoplasmic, score 8.87
MHALACOG_00780	0.0	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MHALACOG_00781	2.16e-154	-	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
MHALACOG_00782	1.8e-220	-	-	-	K	-	-	-	Bacterial regulatory helix-turn-helix protein, lysR family
MHALACOG_00783	5.13e-267	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_00784	1.98e-23	-	-	-	-	-	-	-	-
MHALACOG_00785	4.64e-160	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MHALACOG_00786	1.7e-233	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MHALACOG_00787	3.73e-201	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
MHALACOG_00788	3.01e-224	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the OMP decarboxylase family. Type 2 subfamily
MHALACOG_00789	0.0	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MHALACOG_00790	2.51e-94	pyrI	-	-	F	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002	Aspartate carbamoyltransferase regulatory chain, allosteric domain protein
MHALACOG_00791	8.33e-228	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
MHALACOG_00792	0.0	glnE	2.7.7.42, 2.7.7.89	-	H	ko:K00982	-	ko00000,ko01000	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
MHALACOG_00793	9.88e-239	cbh	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
MHALACOG_00794	6.94e-202	metF	1.5.1.20	-	E	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
MHALACOG_00795	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MHALACOG_00796	1.95e-127	sixA	-	-	T	ko:K08296	-	ko00000,ko01000	Phosphoglycerate mutase family
MHALACOG_00797	7.31e-247	trmI	2.1.1.219, 2.1.1.220	-	J	ko:K07442	-	ko00000,ko01000,ko03016	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MHALACOG_00798	1.87e-121	-	-	-	S	ko:K06999	-	ko00000	Phospholipase/Carboxylesterase
MHALACOG_00799	2.81e-196	-	-	-	S	-	-	-	Aldo/keto reductase family
MHALACOG_00800	9.21e-216	-	-	-	I	-	-	-	alpha/beta hydrolase fold
MHALACOG_00801	2.2e-225	-	1.1.1.1	-	S	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
MHALACOG_00802	5.28e-32	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00803	1.74e-32	-	-	-	S	-	-	-	Bacteriophage abortive infection AbiH
MHALACOG_00804	3.89e-44	-	-	-	-	-	-	-	-
MHALACOG_00805	9.46e-84	-	-	-	S	-	-	-	PFAM Uncharacterised protein family (UPF0153)
MHALACOG_00806	4.07e-37	-	-	-	-	-	-	-	-
MHALACOG_00807	1.73e-97	-	-	-	-	-	-	-	-
MHALACOG_00808	3.92e-98	-	-	-	O	-	-	-	ADP-ribosylglycohydrolase
MHALACOG_00809	1.1e-28	-	-	-	K	-	-	-	Helix-turn-helix domain
MHALACOG_00811	2.3e-170	-	-	-	-	-	-	-	-
MHALACOG_00812	2.09e-119	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Redoxin
MHALACOG_00813	2.13e-191	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
MHALACOG_00814	9.86e-201	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00815	1.08e-308	glgA	2.4.1.342	GT4	G	ko:K16148	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000,ko01003	Starch synthase catalytic domain
MHALACOG_00816	6.92e-106	-	-	-	-	-	-	-	-
MHALACOG_00817	0.0	-	-	-	S	-	-	-	Glycosyl hydrolases related to GH101 family, GH129
MHALACOG_00818	0.0	dppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
MHALACOG_00819	0.0	gltD	1.4.1.13, 1.4.1.14	-	C	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
MHALACOG_00820	0.0	gltB	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase NADPH large subunit
MHALACOG_00821	2.14e-58	-	-	-	K	-	-	-	purine nucleotide biosynthetic process
MHALACOG_00822	4.1e-250	-	1.4.1.12, 1.4.1.26	-	S	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	ko00000,ko00001,ko01000	Dihydrodipicolinate reductase, N-terminus
MHALACOG_00823	1.54e-43	-	-	-	-	-	-	-	-
MHALACOG_00825	6.06e-251	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_00826	7.7e-227	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_00829	3.11e-266	-	-	-	V	-	-	-	MatE
MHALACOG_00830	3.17e-183	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
MHALACOG_00831	1.62e-247	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MHALACOG_00832	2.01e-309	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
MHALACOG_00833	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MHALACOG_00834	2.75e-46	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
MHALACOG_00835	1.01e-179	-	-	-	S	-	-	-	UPF0126 domain
MHALACOG_00836	4.2e-154	mazG	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	Psort location Cytoplasmic, score 8.87
MHALACOG_00837	1.92e-288	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Amino-transferase class IV
MHALACOG_00838	7e-111	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MHALACOG_00839	3.62e-246	-	-	-	S	ko:K06889	-	ko00000	alpha beta
MHALACOG_00840	2.69e-311	pntB	1.6.1.2	-	C	ko:K00325	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MHALACOG_00841	5.05e-58	pntAB	1.6.1.2	-	C	ko:K00324	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	4TM region of pyridine nucleotide transhydrogenase, mitoch
MHALACOG_00842	7.42e-258	pntA	1.6.1.2	-	C	ko:K00324	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	NAD(P) transhydrogenase subunit alpha part 1 K00324
MHALACOG_00843	0.0	fadD2	6.2.1.3	-	I	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme
MHALACOG_00844	1.97e-234	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MHALACOG_00845	0.0	corC	-	-	S	-	-	-	CBS domain
MHALACOG_00846	5.88e-132	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MHALACOG_00847	4.11e-273	phoH	-	-	T	ko:K06217	-	ko00000	PhoH-like protein
MHALACOG_00848	3.36e-77	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	Scavenger mRNA decapping enzyme C-term binding
MHALACOG_00849	1.56e-184	-	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MHALACOG_00851	6.22e-209	spoU2	-	-	J	-	-	-	SpoU rRNA Methylase family
MHALACOG_00852	1.53e-307	glgC	2.7.7.27	-	H	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MHALACOG_00853	2.36e-143	-	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
MHALACOG_00854	1.18e-132	iscU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
MHALACOG_00855	2.83e-299	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MHALACOG_00856	5.66e-184	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
MHALACOG_00857	8.39e-299	sufD	-	-	O	ko:K09015	-	ko00000	FeS assembly protein SufD
MHALACOG_00858	0.0	sufB	-	-	O	ko:K09014	-	ko00000	FeS assembly protein SufB
MHALACOG_00859	1.09e-182	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
MHALACOG_00860	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MHALACOG_00861	5.74e-55	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Dipeptidase
MHALACOG_00862	4.94e-103	aroQ	4.2.1.10	-	E	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a trans-dehydration via an enolate intermediate
MHALACOG_00863	0.0	aroB	2.7.1.71, 4.2.3.4	-	H	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MHALACOG_00864	4.5e-279	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MHALACOG_00865	1.19e-98	-	3.4.23.43	-	S	ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type IV leader peptidase family
MHALACOG_00866	3.24e-255	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MHALACOG_00867	2.33e-103	ruvX	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MHALACOG_00868	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MHALACOG_00869	2.29e-48	-	-	-	-	-	-	-	-
MHALACOG_00870	3.5e-84	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF948)
MHALACOG_00871	3.34e-148	-	5.4.2.12	-	G	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Phosphoglycerate mutase family
MHALACOG_00872	3.79e-294	-	-	-	I	-	-	-	Psort location CytoplasmicMembrane, score 9.99
MHALACOG_00873	1.29e-141	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MHALACOG_00874	2.3e-189	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
MHALACOG_00875	4.97e-272	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
MHALACOG_00876	1.73e-84	-	-	-	S	-	-	-	Domain of unknown function (DUF4418)
MHALACOG_00877	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MHALACOG_00878	2.86e-133	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MHALACOG_00879	1.66e-304	pbuX	-	-	F	ko:K03458	-	ko00000	Permease family
MHALACOG_00880	6.32e-42	-	-	-	K	ko:K07727	-	ko00000,ko03000	Cro/C1-type HTH DNA-binding domain
MHALACOG_00881	1.07e-52	-	-	-	S	-	-	-	Protein of unknown function (DUF2975)
MHALACOG_00882	1.03e-202	-	-	-	I	-	-	-	Serine aminopeptidase, S33
MHALACOG_00883	5.65e-206	-	-	-	M	-	-	-	pfam nlp p60
MHALACOG_00884	2.65e-93	gloA	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MHALACOG_00885	6.9e-135	pncA	3.5.1.19	-	Q	ko:K08281	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Isochorismatase family
MHALACOG_00886	0.0	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal
MHALACOG_00887	0.0	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
MHALACOG_00888	7.02e-287	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
MHALACOG_00889	2.52e-237	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_00890	2.12e-14	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
MHALACOG_00891	1.26e-288	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00892	8.58e-140	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00893	1.35e-147	-	-	-	P	ko:K07220	-	ko00000	Protein of unknown function DUF47
MHALACOG_00894	3.86e-239	pitB	-	-	P	ko:K03306	-	ko00000	Phosphate transporter family
MHALACOG_00895	0.0	nplT	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
MHALACOG_00896	4.46e-55	-	-	-	K	-	-	-	WHG domain
MHALACOG_00897	0.0	-	-	-	JKL	-	-	-	helicase superfamily c-terminal domain
MHALACOG_00898	1.63e-296	rutG	-	-	F	ko:K02824,ko:K03458	-	ko00000,ko02000	Permease family
MHALACOG_00899	2.54e-209	-	-	-	G	-	-	-	Phosphoglycerate mutase family
MHALACOG_00900	1.85e-156	-	-	-	KLT	-	-	-	Protein tyrosine kinase
MHALACOG_00901	0.0	-	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
MHALACOG_00902	0.0	-	-	-	U	-	-	-	Drug resistance MFS transporter, drug H antiporter-2 family
MHALACOG_00903	7.74e-17	-	-	-	-	-	-	-	-
MHALACOG_00904	4.36e-24	yccF	-	-	S	-	-	-	Inner membrane component domain
MHALACOG_00908	2.91e-26	-	-	-	L	-	-	-	Site-specific recombinase, DNA invertase Pin
MHALACOG_00909	2.54e-30	-	-	-	-	-	-	-	-
MHALACOG_00910	4.08e-17	-	-	-	S	-	-	-	Putative phage holin Dp-1
MHALACOG_00911	4.77e-130	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
MHALACOG_00913	2.67e-05	-	-	-	-	-	-	-	-
MHALACOG_00915	1.98e-181	-	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_00916	1.66e-83	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00917	5.44e-188	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00918	2.28e-24	-	-	-	S	-	-	-	Terminase
MHALACOG_00919	0.000195	-	-	-	-	-	-	-	-
MHALACOG_00920	2.78e-51	-	-	-	V	-	-	-	HNH nucleases
MHALACOG_00924	1.52e-261	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_00925	0.0	-	-	-	S	-	-	-	ATPases associated with a variety of cellular activities
MHALACOG_00926	2.17e-122	-	-	-	K	-	-	-	FR47-like protein
MHALACOG_00927	2.32e-152	-	3.1.3.3	-	E	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01009	haloacid dehalogenase-like hydrolase
MHALACOG_00928	0.0	-	-	-	D	-	-	-	Cell surface antigen C-terminus
MHALACOG_00931	9.05e-52	-	-	-	-	-	-	-	-
MHALACOG_00932	2.47e-189	-	-	-	-	-	-	-	-
MHALACOG_00933	5.45e-240	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00934	0.0	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00935	6.62e-166	istB	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_00936	3.24e-114	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00937	3.99e-100	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
MHALACOG_00938	2.86e-152	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_00939	1.33e-276	-	-	-	G	-	-	-	Transmembrane secretion effector
MHALACOG_00940	4.87e-24	higA	-	-	K	ko:K21498	-	ko00000,ko02048	Helix-turn-helix
MHALACOG_00941	9.28e-311	-	-	-	S	-	-	-	HipA-like C-terminal domain
MHALACOG_00942	5.09e-51	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
MHALACOG_00943	2.33e-68	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
MHALACOG_00944	9.63e-110	-	-	-	S	-	-	-	Cupin 2, conserved barrel domain protein
MHALACOG_00945	6.44e-205	-	-	-	J	-	-	-	Methyltransferase domain
MHALACOG_00946	1.92e-79	yccF	-	-	S	-	-	-	Inner membrane component domain
MHALACOG_00947	2.61e-298	-	-	-	K	-	-	-	Fic/DOC family
MHALACOG_00948	5.54e-33	-	-	-	L	-	-	-	Transposase, Mutator family
MHALACOG_00949	0.0	-	-	-	L	-	-	-	ABC transporter
MHALACOG_00950	7.76e-313	-	-	-	V	-	-	-	MatE
MHALACOG_00951	1.96e-38	-	-	-	S	ko:K02890,ko:K07343	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	rRNA binding
MHALACOG_00952	3.48e-75	tetD	-	-	K	ko:K13653	-	ko00000,ko03000	Arac family
MHALACOG_00953	2.65e-115	tetD	-	-	K	ko:K13653	-	ko00000,ko03000	Arac family
MHALACOG_00954	3.56e-259	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MHALACOG_00955	6.32e-164	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MHALACOG_00956	0.0	pip	3.4.11.5	-	S	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	alpha/beta hydrolase fold
MHALACOG_00957	0.0	-	-	-	T	-	-	-	Histidine kinase
MHALACOG_00958	8.86e-42	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00959	1.16e-87	-	-	-	K	-	-	-	helix_turn_helix, Lux Regulon
MHALACOG_00960	0.0	-	-	-	MV	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
MHALACOG_00961	5.36e-159	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MHALACOG_00962	2.12e-310	-	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Aminotransferase class-V
MHALACOG_00963	1.53e-208	pdxY	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Phosphomethylpyrimidine kinase
MHALACOG_00964	8.53e-120	yraN	-	-	L	ko:K07460	-	ko00000	Belongs to the UPF0102 family
MHALACOG_00965	0.0	comM	-	-	O	ko:K07391	-	ko00000	Magnesium chelatase, subunit ChlI C-terminal
MHALACOG_00966	0.0	dprA	-	-	LU	ko:K04096	-	ko00000	DNA recombination-mediator protein A
MHALACOG_00967	0.0	sdhA	1.3.5.1, 1.3.5.4, 1.4.3.16	-	C	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	Succinate dehydrogenase flavoprotein subunit
MHALACOG_00968	5.43e-229	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	4Fe-4S dicluster domain
MHALACOG_00969	2.2e-143	safC	-	-	S	-	-	-	O-methyltransferase
MHALACOG_00970	1.06e-206	fmt2	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
MHALACOG_00971	6.31e-309	nhaA	-	-	P	ko:K03313	-	ko00000,ko02000	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MHALACOG_00974	4.7e-310	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MHALACOG_00975	2.2e-159	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MHALACOG_00976	1.71e-150	clpP1	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MHALACOG_00977	9.84e-79	-	-	-	-	-	-	-	-
MHALACOG_00978	6.04e-299	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
MHALACOG_00979	2.34e-302	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MHALACOG_00980	1.92e-316	rnd	3.1.13.5	-	J	ko:K03684	-	ko00000,ko01000,ko03016	3'-5' exonuclease
MHALACOG_00981	1.25e-150	-	-	-	S	-	-	-	Protein of unknown function (DUF3000)
MHALACOG_00982	2.47e-220	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MHALACOG_00983	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
MHALACOG_00984	2.37e-46	-	-	-	-	-	-	-	-
MHALACOG_00985	0.0	nadE	6.3.5.1	-	H	ko:K01950	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MHALACOG_00986	4.03e-285	-	-	-	S	-	-	-	Peptidase dimerisation domain
MHALACOG_00987	1.12e-145	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_00988	5.05e-279	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MHALACOG_00989	1e-222	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	NLPA lipoprotein
MHALACOG_00991	5.75e-201	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
MHALACOG_00992	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
MHALACOG_00993	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
MHALACOG_00994	5.84e-55	arsB	-	-	P	ko:K03325	-	ko00000,ko02000	PFAM Bile acid sodium symporter
MHALACOG_00995	6.78e-77	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MHALACOG_00996	9.82e-30	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
MHALACOG_00997	1.98e-181	-	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_00998	1.66e-83	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_00999	5.44e-188	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01000	2.37e-33	-	-	-	L	-	-	-	COG3436 Transposase and inactivated derivatives
MHALACOG_01003	2.6e-11	-	-	-	S	-	-	-	Domain of unknown function DUF87
MHALACOG_01004	2.23e-18	-	-	-	S	-	-	-	DNA/RNA non-specific endonuclease
MHALACOG_01005	2.21e-08	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MHALACOG_01006	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF1846)
MHALACOG_01007	0.0	yrhL	-	-	I	-	-	-	Psort location CytoplasmicMembrane, score 9.99
MHALACOG_01008	3.21e-244	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MHALACOG_01010	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MHALACOG_01011	8.12e-90	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MHALACOG_01012	3.56e-169	gpmB	3.1.3.85, 5.4.2.11	-	G	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Phosphoglycerate mutase family
MHALACOG_01015	0.0	pta	2.3.1.8	-	C	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphate acetyltransferase
MHALACOG_01016	3.27e-295	ackA	2.7.2.1	-	H	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MHALACOG_01017	0.0	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MHALACOG_01018	1.44e-277	-	-	-	-	-	-	-	-
MHALACOG_01019	4.49e-100	bga1	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Psort location Cytoplasmic, score 8.87
MHALACOG_01020	0.0	gph	-	-	G	ko:K16209	-	ko00000,ko02000	Psort location CytoplasmicMembrane, score 10.00
MHALACOG_01022	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Psort location Cytoplasmic, score 8.87
MHALACOG_01024	1.56e-137	-	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
MHALACOG_01026	5.09e-161	-	-	-	S	-	-	-	GyrI-like small molecule binding domain
MHALACOG_01027	1.43e-115	-	-	-	K	-	-	-	Putative zinc ribbon domain
MHALACOG_01028	3.36e-38	zntR	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MHALACOG_01029	0.0	glgX	3.2.1.68	CBM48,GH13	G	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 13 family
MHALACOG_01030	8.08e-162	-	-	-	L	-	-	-	NUDIX domain
MHALACOG_01031	1.89e-226	-	-	-	L	-	-	-	NIF3 (NGG1p interacting factor 3)
MHALACOG_01032	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MHALACOG_01033	1.01e-162	pdtaR	-	-	T	ko:K22010	-	ko00000,ko00002,ko02022	Response regulator receiver domain protein
MHALACOG_01034	4.22e-184	intA	-	-	L	-	-	-	Phage integrase family
MHALACOG_01036	1.76e-13	-	-	-	S	-	-	-	Protein of unknown function (DUF1778)
MHALACOG_01037	5.25e-50	-	-	-	-	-	-	-	-
MHALACOG_01038	1.61e-36	-	-	-	-	-	-	-	-
MHALACOG_01041	2.37e-08	-	-	-	-	-	-	-	-
MHALACOG_01042	2.31e-169	-	-	-	M	-	-	-	Bacteriophage peptidoglycan hydrolase
MHALACOG_01045	8.86e-84	-	-	-	-	-	-	-	-
MHALACOG_01046	3.86e-173	-	-	-	-	-	-	-	-
MHALACOG_01053	2.8e-83	-	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
MHALACOG_01054	7.84e-66	-	-	-	-	-	-	-	-
MHALACOG_01055	2.16e-06	-	-	-	S	ko:K07052	-	ko00000	Amino terminal protease
MHALACOG_01056	1.08e-27	-	-	-	-	ko:K03646	-	ko00000,ko02000	-
MHALACOG_01057	9.43e-41	-	-	-	-	ko:K03646	-	ko00000,ko02000	-
MHALACOG_01058	0.0	-	-	-	D	-	-	-	Cell surface antigen C-terminus
MHALACOG_01059	1.14e-87	-	-	-	M	-	-	-	Pilin isopeptide linkage domain protein
MHALACOG_01061	6.42e-10	-	-	-	D	-	-	-	nuclear chromosome segregation
MHALACOG_01063	1.55e-66	-	-	-	-	-	-	-	-
MHALACOG_01066	4.91e-48	-	-	-	S	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
MHALACOG_01068	1.42e-234	-	-	-	U	-	-	-	Type IV secretory pathway, VirB4
MHALACOG_01069	3.92e-268	-	-	-	U	-	-	-	TraM recognition site of TraD and TraG
MHALACOG_01074	1.56e-42	-	-	-	-	-	-	-	-
MHALACOG_01075	6.02e-197	-	-	-	S	-	-	-	HipA-like C-terminal domain
MHALACOG_01077	0.0	-	-	-	L	-	-	-	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MHALACOG_01080	2.05e-33	-	-	-	S	-	-	-	Antitoxin component of a toxin-antitoxin (TA) module
MHALACOG_01086	3.58e-12	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-stranded DNA-binding protein
MHALACOG_01088	1.36e-15	-	-	-	L	-	-	-	Domain of unknown function (DUF3846)
MHALACOG_01093	2.77e-84	-	-	-	S	-	-	-	Glutamine amidotransferases class-II
MHALACOG_01094	4.79e-96	-	-	-	-	-	-	-	-
MHALACOG_01095	5.9e-61	-	-	-	K	-	-	-	sequence-specific DNA binding
MHALACOG_01096	5.25e-35	-	-	-	S	-	-	-	Protein of unknown function (DUF1778)
MHALACOG_01097	6.55e-79	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
MHALACOG_01099	5.2e-195	-	3.6.4.12	-	F	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RecQ zinc-binding
MHALACOG_01100	4.94e-94	-	-	-	L	-	-	-	helicase
MHALACOG_01102	1.63e-97	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01103	5.96e-126	-	-	-	S	-	-	-	Nucleotidyl transferase AbiEii toxin, Type IV TA system
MHALACOG_01108	1.03e-22	-	-	-	-	-	-	-	-
MHALACOG_01109	2.71e-52	-	-	-	-	-	-	-	-
MHALACOG_01112	1.29e-79	-	-	-	K	-	-	-	Helix-turn-helix domain
MHALACOG_01117	6.62e-166	istB	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_01118	0.0	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01120	1.84e-68	ydhQ	2.7.11.1	-	MU	ko:K12132	-	ko00000,ko01000,ko01001	cell adhesion
MHALACOG_01125	6.48e-142	aspA	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	NUDIX domain
MHALACOG_01126	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Pyruvate kinase
MHALACOG_01127	3.81e-228	terC	-	-	P	ko:K05794	-	ko00000	Integral membrane protein, TerC family
MHALACOG_01128	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MHALACOG_01129	7.03e-124	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MHALACOG_01130	0.0	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
MHALACOG_01131	1.7e-201	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MHALACOG_01132	4.69e-247	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Zinc-uptake complex component A periplasmic
MHALACOG_01134	2e-207	-	-	-	P	ko:K02074	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01135	1.91e-175	znuB	-	-	U	ko:K02075	-	ko00000,ko00002,ko02000	ABC 3 transport family
MHALACOG_01136	1.63e-116	ispF	2.7.7.60, 4.6.1.12	-	H	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MHALACOG_01137	5.29e-131	carD	-	-	K	ko:K07736	-	ko00000,ko03000	CarD-like/TRCF domain
MHALACOG_01138	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MHALACOG_01139	8.63e-165	cseB	-	-	T	-	-	-	Response regulator receiver domain protein
MHALACOG_01140	2.64e-245	-	-	-	T	-	-	-	ATPase histidine kinase DNA gyrase B HSP90 domain protein
MHALACOG_01141	1.39e-79	umuD	-	-	KT	ko:K03503	-	ko00000,ko01000,ko01002,ko03400	Peptidase S24-like
MHALACOG_01142	2.29e-72	pyrE_1	-	-	S	-	-	-	Phosphoribosyl transferase domain
MHALACOG_01143	1.57e-192	-	-	-	T	-	-	-	Eukaryotic phosphomannomutase
MHALACOG_01144	2.89e-84	-	-	-	S	-	-	-	Zincin-like metallopeptidase
MHALACOG_01145	0.0	-	-	-	-	-	-	-	-
MHALACOG_01146	0.0	-	-	-	S	-	-	-	Glycosyl transferase, family 2
MHALACOG_01147	2.92e-74	whiB2	-	-	K	ko:K18955	-	ko00000,ko03000	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MHALACOG_01148	2.54e-207	lytR2	-	-	K	-	-	-	Cell envelope-related transcriptional attenuator domain
MHALACOG_01149	0.0	-	-	-	D	ko:K03466	-	ko00000,ko03036	FtsK/SpoIIIE family
MHALACOG_01150	3.32e-61	whiB	-	-	K	ko:K18955	-	ko00000,ko03000	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA
MHALACOG_01151	0.0	pdtaS	2.7.13.3	-	T	ko:K00936	-	ko00000,ko00002,ko01000,ko01001,ko02022	ATPase histidine kinase DNA gyrase B HSP90 domain protein
MHALACOG_01152	5.49e-13	-	-	-	S	-	-	-	Beta-lactamase enzyme family
MHALACOG_01153	1.51e-199	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	Haemolysin-III related
MHALACOG_01154	7.1e-106	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MHALACOG_01155	7.86e-96	fkbP	5.2.1.8	-	G	ko:K01802	-	ko00000,ko01000	Peptidyl-prolyl cis-trans
MHALACOG_01156	0.0	sdaA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase alpha chain
MHALACOG_01157	9.54e-121	-	-	-	-	-	-	-	-
MHALACOG_01159	1.75e-231	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	Ppx/GppA phosphatase family
MHALACOG_01160	5.6e-133	-	-	-	S	ko:K09009	-	ko00000	Protein of unknown function (DUF501)
MHALACOG_01161	7.89e-103	-	-	-	D	-	-	-	Septum formation initiator
MHALACOG_01162	1.61e-309	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MHALACOG_01163	2.59e-227	-	-	-	C	-	-	-	Aldo/keto reductase family
MHALACOG_01164	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MHALACOG_01165	4.23e-147	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MHALACOG_01166	1.04e-119	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
MHALACOG_01167	0.0	-	-	-	S	ko:K09118	-	ko00000	Uncharacterised protein family (UPF0182)
MHALACOG_01168	1.7e-263	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Glycosyl hydrolase family 3 N-terminal domain protein
MHALACOG_01169	2.29e-175	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MHALACOG_01170	6.21e-128	-	-	-	-	-	-	-	-
MHALACOG_01171	1.74e-292	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MHALACOG_01172	7.46e-125	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MHALACOG_01173	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase N terminus
MHALACOG_01174	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	ATPase, P-type (transporting), HAD superfamily, subfamily IC
MHALACOG_01175	4.17e-86	-	-	-	S	-	-	-	ABC-2 family transporter protein
MHALACOG_01176	3.91e-155	-	-	-	S	-	-	-	ABC-2 family transporter protein
MHALACOG_01177	3.51e-222	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01178	2.84e-77	-	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
MHALACOG_01179	1.4e-153	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
MHALACOG_01180	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
MHALACOG_01181	3.17e-238	nadK	2.7.1.23	-	H	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MHALACOG_01182	0.0	trkH	-	-	P	ko:K03498	-	ko00000,ko02000	Cation transport protein
MHALACOG_01183	4.84e-152	trkA	-	-	P	ko:K03499	-	ko00000,ko02000	TrkA-N domain
MHALACOG_01184	5.82e-130	-	-	-	-	-	-	-	-
MHALACOG_01185	1.23e-177	tlyA	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
MHALACOG_01187	4.97e-249	-	-	-	G	-	-	-	Haloacid dehalogenase-like hydrolase
MHALACOG_01188	3.05e-221	-	-	-	L	-	-	-	Tetratricopeptide repeat
MHALACOG_01189	0.0	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MHALACOG_01190	1.1e-179	-	-	-	S	-	-	-	Putative ABC-transporter type IV
MHALACOG_01191	1.1e-129	-	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
MHALACOG_01192	1.51e-74	-	-	-	P	-	-	-	Rhodanese Homology Domain
MHALACOG_01193	2.8e-189	thiF	2.7.7.73, 2.7.7.80, 2.8.1.11	-	H	ko:K03148,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	ThiF family
MHALACOG_01194	1.02e-201	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MHALACOG_01195	5.04e-39	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	ThiS family
MHALACOG_01196	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
MHALACOG_01197	2.83e-302	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
MHALACOG_01198	4.66e-105	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
MHALACOG_01199	1.02e-233	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MHALACOG_01200	2.81e-314	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
MHALACOG_01201	3.68e-212	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
MHALACOG_01202	3.94e-271	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MHALACOG_01203	5.27e-260	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MHALACOG_01204	5.08e-142	-	-	-	-	-	-	-	-
MHALACOG_01205	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Phenylalanyl-tRNA synthetase beta
MHALACOG_01206	7.14e-256	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MHALACOG_01207	2.83e-205	tsnR	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MHALACOG_01208	9.39e-191	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
MHALACOG_01209	0.0	ykoD	-	-	P	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01210	4.38e-140	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
MHALACOG_01211	0.0	argE	-	-	E	-	-	-	Peptidase dimerisation domain
MHALACOG_01212	1.56e-137	-	-	-	S	-	-	-	Protein of unknown function (DUF3043)
MHALACOG_01213	0.0	lpdA	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MHALACOG_01214	1.32e-178	-	-	-	S	-	-	-	Domain of unknown function (DUF4191)
MHALACOG_01215	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
MHALACOG_01216	1.64e-129	-	3.2.1.23, 3.2.1.31	-	G	ko:K01190,ko:K01195	ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142	ko00000,ko00001,ko00002,ko01000	Glycosyl hydrolases family 2, TIM barrel domain
MHALACOG_01217	1.33e-236	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
MHALACOG_01218	1.29e-58	-	2.3.1.18, 2.3.1.79	-	S	ko:K00633,ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
MHALACOG_01219	2.3e-154	-	2.3.1.18, 2.3.1.79	-	S	ko:K00633,ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
MHALACOG_01220	0.00015	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
MHALACOG_01221	2.02e-155	-	-	-	L	ko:K07457	-	ko00000	endonuclease III
MHALACOG_01222	1.55e-308	-	-	-	V	-	-	-	MatE
MHALACOG_01223	0.0	uvrA3	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MHALACOG_01224	0.0	-	-	-	H	-	-	-	Protein of unknown function (DUF4012)
MHALACOG_01225	7.19e-104	-	-	-	S	ko:K07133	-	ko00000	AAA domain
MHALACOG_01226	2.04e-171	-	-	-	C	-	-	-	FMN binding
MHALACOG_01227	3.49e-123	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MHALACOG_01228	5.1e-07	-	-	-	K	-	-	-	MerR, DNA binding
MHALACOG_01229	0.0	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01230	2.1e-246	adh	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Zinc-binding dehydrogenase
MHALACOG_01231	6.07e-114	-	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MHALACOG_01232	1.6e-77	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MHALACOG_01233	2.2e-80	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
MHALACOG_01234	2.39e-235	-	-	-	S	-	-	-	Conserved hypothetical protein 698
MHALACOG_01235	1.61e-185	-	-	-	K	-	-	-	Bacterial regulatory helix-turn-helix protein, lysR family
MHALACOG_01236	2.56e-165	tmp1	-	-	S	-	-	-	Domain of unknown function (DUF4391)
MHALACOG_01237	3.51e-294	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MHALACOG_01238	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MHALACOG_01239	1.9e-104	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MHALACOG_01240	5.77e-81	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MHALACOG_01242	6.47e-244	-	-	-	S	ko:K03453	-	ko00000	SBF-like CPA transporter family (DUF4137)
MHALACOG_01244	2.77e-248	ltaE	4.1.2.48	-	E	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Beta-eliminating lyase
MHALACOG_01245	9.71e-274	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
MHALACOG_01246	2.36e-304	purT	2.1.2.2	-	F	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MHALACOG_01247	1.44e-177	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
MHALACOG_01248	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	CobB/CobQ-like glutamine amidotransferase domain
MHALACOG_01249	2.38e-291	-	-	-	I	-	-	-	alpha/beta hydrolase fold
MHALACOG_01250	0.0	-	-	-	Q	-	-	-	D-alanine [D-alanyl carrier protein] ligase activity
MHALACOG_01251	2.56e-142	-	-	-	Q	-	-	-	D-alanine [D-alanyl carrier protein] ligase activity
MHALACOG_01252	1.57e-244	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter family protein
MHALACOG_01253	1.43e-27	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter family protein
MHALACOG_01254	1.04e-112	-	-	-	K	-	-	-	DNA-binding transcription factor activity
MHALACOG_01255	2.28e-223	-	-	-	C	-	-	-	Aldo/keto reductase family
MHALACOG_01256	4.69e-43	-	-	-	-	-	-	-	-
MHALACOG_01257	0.0	-	-	-	L	ko:K03502	-	ko00000,ko03400	DNA-damage repair protein (DNA polymerase IV) K00961
MHALACOG_01258	8.96e-243	-	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	S-adenosyl-L-homocysteine hydrolase, NAD binding domain
MHALACOG_01259	1.1e-300	-	-	-	F	-	-	-	Amidohydrolase family
MHALACOG_01260	4.08e-85	-	-	-	S	ko:K09705	-	ko00000	Cupin superfamily (DUF985)
MHALACOG_01261	2.47e-165	-	-	-	ET	ko:K02030,ko:K02424,ko:K17073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Bacterial periplasmic substrate-binding proteins
MHALACOG_01262	8.01e-161	-	-	-	E	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01263	1.04e-152	-	3.6.3.21	-	E	ko:K02028,ko:K02029	-	ko00000,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
MHALACOG_01264	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MHALACOG_01265	9.14e-240	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
MHALACOG_01266	1e-307	purD	6.3.3.1, 6.3.4.13	-	F	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
MHALACOG_01267	0.0	aldH	1.2.1.3, 1.2.99.10	-	C	ko:K00128,ko:K22445	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldehyde dehydrogenase family
MHALACOG_01268	0.0	-	-	-	M	-	-	-	Psort location CytoplasmicMembrane, score 9.26
MHALACOG_01269	1.46e-210	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Zinc-uptake complex component A periplasmic
MHALACOG_01270	1.78e-42	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	efflux transmembrane transporter activity
MHALACOG_01271	3.67e-93	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
MHALACOG_01272	5.58e-292	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MHALACOG_01273	4.02e-109	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MHALACOG_01274	2.11e-226	yogA	-	-	C	-	-	-	Zinc-binding dehydrogenase
MHALACOG_01275	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MHALACOG_01276	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
MHALACOG_01277	5.85e-193	-	-	-	M	-	-	-	Conserved repeat domain
MHALACOG_01278	9.81e-168	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01280	8.67e-276	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal
MHALACOG_01281	7.51e-204	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
MHALACOG_01282	0.0	-	-	-	G	-	-	-	Alpha-L-arabinofuranosidase C-terminal domain
MHALACOG_01283	3.16e-40	-	-	-	-	-	-	-	-
MHALACOG_01284	1.38e-273	-	-	-	P	-	-	-	Citrate transporter
MHALACOG_01285	2.49e-08	dppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
MHALACOG_01286	4.22e-216	iaaA	3.4.19.5	-	E	ko:K13051	-	ko00000,ko01000,ko01002	Asparaginase
MHALACOG_01287	0.0	-	-	-	EK	ko:K03710,ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000,ko03000	Alanine-glyoxylate amino-transferase
MHALACOG_01288	6.92e-148	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MHALACOG_01289	1.63e-199	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MHALACOG_01290	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MHALACOG_01291	2.91e-316	dgt	3.1.5.1	-	F	ko:K01129	ko00230,map00230	ko00000,ko00001,ko01000	Phosphohydrolase-associated domain
MHALACOG_01292	0.0	alr	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MHALACOG_01293	0.0	aap1	-	-	E	ko:K03294	-	ko00000	aromatic amino acid transport protein AroP K03293
MHALACOG_01294	1.45e-131	cysE	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MHALACOG_01295	4.59e-118	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MHALACOG_01296	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
MHALACOG_01297	0.0	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
MHALACOG_01298	2.51e-280	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Cys/Met metabolism PLP-dependent enzyme
MHALACOG_01299	6.87e-256	cbs	2.5.1.47, 4.2.1.22	-	E	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
MHALACOG_01300	1.87e-174	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01301	4.21e-156	-	-	-	EP	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	oligopeptide transport protein of the ABC superfamily, ATP-binding component
MHALACOG_01302	2.39e-157	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01303	1.17e-193	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01304	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, family 5
MHALACOG_01305	5.03e-181	coaX	2.7.1.33	-	H	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MHALACOG_01306	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01307	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01308	8.73e-314	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01309	0.0	abfA1	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	arabinose metabolic process
MHALACOG_01310	2.05e-232	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01311	0.0	bga1	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Psort location Cytoplasmic, score 8.87
MHALACOG_01313	2.19e-226	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	ABC transporter permease
MHALACOG_01314	2.97e-215	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01315	4.91e-233	-	-	-	K	-	-	-	Periplasmic binding protein domain
MHALACOG_01316	2.24e-37	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MHALACOG_01317	2.36e-180	-	5.4.99.28, 5.4.99.29	-	J	ko:K06177	-	ko00000,ko01000,ko03009,ko03016	RNA pseudouridylate synthase
MHALACOG_01318	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MHALACOG_01319	7.44e-193	tcyC	3.6.3.21	-	E	ko:K02028,ko:K02029	-	ko00000,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01320	3.62e-223	yecS	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01321	2.79e-205	glnH	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter, substrate-binding protein, family 3
MHALACOG_01322	9.23e-201	glnH	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter, substrate-binding protein, family 3
MHALACOG_01323	4.64e-106	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
MHALACOG_01324	5.08e-287	-	-	-	D	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain protein
MHALACOG_01325	1.9e-206	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in cellular division
MHALACOG_01326	4.01e-226	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Cell division ATP-binding protein FtsE
MHALACOG_01327	2.16e-264	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MHALACOG_01328	0.0	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01329	2.15e-158	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MHALACOG_01330	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MHALACOG_01332	9e-72	-	-	-	KL	-	-	-	Type III restriction enzyme res subunit
MHALACOG_01333	6.55e-179	-	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
MHALACOG_01334	0.0	pepN	3.4.11.2	-	E	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Peptidase family M1 domain
MHALACOG_01335	0.0	rnj	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MHALACOG_01336	3.34e-208	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MHALACOG_01337	7.31e-167	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MHALACOG_01338	4.52e-299	-	-	-	G	-	-	-	Major Facilitator Superfamily
MHALACOG_01339	0.0	uvrD2	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	Belongs to the helicase family. UvrD subfamily
MHALACOG_01340	0.0	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
MHALACOG_01341	0.0	pknK	2.7.11.1	-	KLT	ko:K12132	-	ko00000,ko01000,ko01001	Protein tyrosine kinase
MHALACOG_01342	0.0	-	-	-	S	-	-	-	Fibronectin type 3 domain
MHALACOG_01343	5.44e-249	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
MHALACOG_01344	3.74e-284	-	-	-	S	-	-	-	Protein of unknown function DUF58
MHALACOG_01345	0.0	-	-	-	E	-	-	-	Transglutaminase-like superfamily
MHALACOG_01346	3.81e-203	-	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	Sigma factor PP2C-like phosphatases
MHALACOG_01347	1.57e-99	-	-	-	B	-	-	-	Belongs to the OprB family
MHALACOG_01348	1.72e-118	-	-	-	T	-	-	-	Forkhead associated domain
MHALACOG_01349	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MHALACOG_01350	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MHALACOG_01351	1.21e-139	-	-	-	-	-	-	-	-
MHALACOG_01352	1.34e-205	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	FES
MHALACOG_01353	1.67e-148	spoU	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MHALACOG_01354	0.0	-	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
MHALACOG_01355	4.59e-58	-	-	-	T	ko:K07166	-	ko00000	Belongs to the UPF0237 family
MHALACOG_01356	0.0	-	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
MHALACOG_01357	5e-253	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MHALACOG_01358	9.28e-148	-	-	-	S	-	-	-	Protein of unknown function, DUF624
MHALACOG_01359	2.02e-219	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01360	6.88e-220	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01361	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01362	5.65e-295	galK	2.7.1.6, 2.7.7.12	-	G	ko:K00849,ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GHMP kinase family. GalK subfamily
MHALACOG_01363	0.0	galT	2.7.7.12	-	C	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	Galactose-1-phosphate uridyl transferase, N-terminal domain
MHALACOG_01364	2.99e-158	-	-	-	K	-	-	-	DeoR C terminal sensor domain
MHALACOG_01365	3.08e-289	pyrD	1.3.5.2, 1.3.98.1	-	F	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
MHALACOG_01366	0.0	namA	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
MHALACOG_01367	0.0	pon1	-	-	M	-	-	-	Transglycosylase
MHALACOG_01368	6.11e-169	crp	-	-	K	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	helix_turn_helix, cAMP Regulatory protein
MHALACOG_01369	2.38e-254	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
MHALACOG_01370	7.61e-247	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MHALACOG_01371	0.0	ptrB	3.4.21.83	-	E	ko:K01354	ko05142,ko05143,map05142,map05143	ko00000,ko00001,ko01000,ko01002	Peptidase, S9A B C family, catalytic domain protein
MHALACOG_01372	3e-315	-	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2183)
MHALACOG_01373	1.66e-93	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
MHALACOG_01374	7.17e-296	nudC	3.6.1.22	-	L	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	ko00000,ko00001,ko01000	NADH pyrophosphatase zinc ribbon domain
MHALACOG_01375	2.44e-207	-	-	-	I	-	-	-	Alpha/beta hydrolase family
MHALACOG_01376	4.01e-160	-	-	-	F	-	-	-	Domain of unknown function (DUF4916)
MHALACOG_01377	1.59e-78	trxA	1.8.1.9	-	O	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	ko00000,ko00001,ko01000,ko03110	Belongs to the thioredoxin family
MHALACOG_01378	4.04e-218	-	-	-	S	ko:K21688	-	ko00000	G5
MHALACOG_01379	9.96e-273	-	-	-	-	-	-	-	-
MHALACOG_01380	9.44e-314	wcoI	-	-	DM	-	-	-	Psort location CytoplasmicMembrane, score
MHALACOG_01381	3.93e-89	-	-	-	-	-	-	-	-
MHALACOG_01382	7.76e-256	tnp3503b	-	-	L	-	-	-	Transposase and inactivated derivatives
MHALACOG_01383	6.63e-203	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MHALACOG_01384	0.0	rfbD	1.1.1.133, 5.1.3.13	-	M	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MHALACOG_01385	2.83e-262	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MHALACOG_01386	2.93e-14	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01387	1.27e-173	-	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_01388	2.11e-61	-	-	-	L	-	-	-	Transposase
MHALACOG_01389	9.07e-204	-	-	-	L	-	-	-	Transposase
MHALACOG_01390	6.62e-166	istB	-	-	L	-	-	-	IstB-like ATP binding protein
MHALACOG_01391	0.0	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01392	5.27e-37	-	-	-	L	-	-	-	Transposase
MHALACOG_01393	3.33e-91	-	-	-	L	-	-	-	Transposase
MHALACOG_01394	4.38e-76	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01395	9.73e-38	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01396	1.08e-69	-	-	-	C	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_01398	4.74e-91	-	-	-	C	-	-	-	Polysaccharide pyruvyl transferase
MHALACOG_01399	4.56e-76	-	-	-	M	-	-	-	Domain of unknown function (DUF4422)
MHALACOG_01400	1.6e-163	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score 9.99
MHALACOG_01401	1.13e-72	-	-	-	S	-	-	-	Glycosyltransferase like family 2
MHALACOG_01402	7.38e-203	-	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	Domain of unknown function (DUF1972)
MHALACOG_01403	9.14e-263	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_01404	2.94e-136	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score 9.99
MHALACOG_01405	8.82e-141	etp	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
MHALACOG_01406	1.44e-289	rfbP	-	-	M	-	-	-	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
MHALACOG_01407	2.82e-54	-	-	-	L	ko:K07483	-	ko00000	Transposase
MHALACOG_01408	4.5e-163	tnp3521a2	-	-	L	-	-	-	Integrase core domain
MHALACOG_01409	0.0	-	-	-	U	-	-	-	Drug resistance MFS transporter, drug H antiporter-2 family
MHALACOG_01410	1.46e-287	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
MHALACOG_01411	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4143)
MHALACOG_01412	7.42e-174	-	-	-	L	-	-	-	Protein of unknown function (DUF1524)
MHALACOG_01413	8.51e-210	-	-	-	S	-	-	-	Oxidoreductase, aldo keto reductase family protein
MHALACOG_01414	0.0	galA	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	Glycosyl hydrolase family 53
MHALACOG_01415	4.07e-246	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01416	0.0	bga1	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Psort location Cytoplasmic, score 8.87
MHALACOG_01417	1.88e-212	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	ABC transporter permease
MHALACOG_01418	9.94e-221	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01419	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01420	2.39e-55	-	-	-	U	ko:K02100	-	ko00000,ko02000	Sugar (and other) transporter
MHALACOG_01421	0.0	-	-	-	V	ko:K06147,ko:K06148,ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter transmembrane region
MHALACOG_01422	1.07e-44	araE	-	-	EGP	ko:K02100	-	ko00000,ko02000	Major facilitator Superfamily
MHALACOG_01423	0.0	fadD	6.2.1.3	-	I	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme
MHALACOG_01424	4.85e-143	vex	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MHALACOG_01425	4.86e-264	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	Efflux ABC transporter, permease protein
MHALACOG_01426	4.65e-284	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
MHALACOG_01427	6.02e-287	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score 9.99
MHALACOG_01428	6.14e-173	-	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
MHALACOG_01429	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
MHALACOG_01430	1.24e-168	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Class II Aldolase and Adducin N-terminal domain
MHALACOG_01431	0.0	araB	-	-	G	-	-	-	FGGY family of carbohydrate kinases, C-terminal domain
MHALACOG_01432	1.47e-265	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01433	9.71e-185	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MHALACOG_01434	2.27e-181	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MHALACOG_01435	6.79e-79	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MHALACOG_01436	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
MHALACOG_01439	2.01e-221	-	-	-	S	ko:K07088	-	ko00000	Auxin Efflux Carrier
MHALACOG_01440	1.17e-308	-	-	-	V	ko:K12554	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Psort location Cytoplasmic, score 8.87
MHALACOG_01441	4.15e-314	-	-	-	V	ko:K12554	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Psort location Cytoplasmic, score 8.87
MHALACOG_01442	4.07e-307	-	-	-	V	ko:K12554	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Psort location Cytoplasmic, score 8.87
MHALACOG_01444	1.05e-171	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MHALACOG_01445	2.22e-185	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MHALACOG_01446	2.46e-315	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MHALACOG_01447	7.84e-152	-	-	-	-	-	-	-	-
MHALACOG_01448	7.11e-91	-	-	-	K	-	-	-	MerR, DNA binding
MHALACOG_01449	3.1e-247	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
MHALACOG_01450	1.03e-164	-	-	-	S	-	-	-	Protein of unknown function (DUF1177)
MHALACOG_01451	6.58e-270	-	-	-	EQ	-	-	-	Hydantoinase/oxoprolinase N-terminal region
MHALACOG_01452	3.89e-180	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
MHALACOG_01453	1.07e-110	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
MHALACOG_01454	1.6e-147	-	-	-	F	ko:K10974	-	ko00000,ko02000	Permease for cytosine/purines, uracil, thiamine, allantoin
MHALACOG_01455	4.04e-132	-	-	-	S	-	-	-	Carbon-nitrogen hydrolase
MHALACOG_01456	1.8e-235	-	-	-	F	ko:K10974	-	ko00000,ko02000	Permease for cytosine/purines, uracil, thiamine, allantoin
MHALACOG_01457	1.08e-66	-	-	-	S	-	-	-	Protein of unknown function (DUF3039)
MHALACOG_01458	3.48e-114	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MHALACOG_01459	1.83e-171	-	-	-	-	-	-	-	-
MHALACOG_01460	2.08e-152	-	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
MHALACOG_01461	3.14e-42	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
MHALACOG_01462	1.28e-167	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MHALACOG_01463	0.0	ilvB	2.2.1.6	-	H	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
MHALACOG_01464	5.15e-118	ilvN	2.2.1.6	-	E	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	ACT domain
MHALACOG_01465	3.74e-58	-	-	-	S	ko:K21495	-	ko00000,ko02048	Plasmid stability protein
MHALACOG_01466	1.69e-83	vapC	-	-	S	ko:K07062	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module. An RNase
MHALACOG_01467	0.0	yjjK	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter
MHALACOG_01468	1.15e-130	dam	2.1.1.72	-	H	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
MHALACOG_01469	4.74e-139	-	-	-	-	-	-	-	-
MHALACOG_01471	1.07e-174	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Peptidase C26
MHALACOG_01472	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
MHALACOG_01473	2.72e-208	-	-	-	P	-	-	-	Cation efflux family
MHALACOG_01474	0.0	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MHALACOG_01475	5.55e-221	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
MHALACOG_01476	1.36e-82	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
MHALACOG_01477	1.24e-47	-	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
MHALACOG_01478	2.17e-141	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MHALACOG_01479	1.9e-163	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
MHALACOG_01480	1.65e-53	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
MHALACOG_01481	4.08e-216	-	-	-	C	-	-	-	Oxidoreductase, aldo keto reductase family protein
MHALACOG_01482	0.0	-	-	-	S	-	-	-	Predicted membrane protein (DUF2207)
MHALACOG_01483	1.03e-121	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
MHALACOG_01484	3.17e-190	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MHALACOG_01485	5.56e-223	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
MHALACOG_01486	1.28e-193	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
MHALACOG_01487	5.65e-257	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import
MHALACOG_01488	4.13e-180	regX3	-	-	KT	ko:K07776	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
MHALACOG_01489	1.66e-303	phoR	2.7.13.3	-	T	ko:K07636,ko:K07768	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
MHALACOG_01490	5.79e-157	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MHALACOG_01491	2.71e-299	aroG	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MHALACOG_01492	5.23e-278	aroG	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MHALACOG_01493	0.0	pepC2	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
MHALACOG_01494	4.98e-146	-	-	-	D	-	-	-	nuclear chromosome segregation
MHALACOG_01495	3.28e-157	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MHALACOG_01496	1.52e-204	ispD	1.1.1.405, 2.7.7.40, 2.7.7.60	-	I	ko:K00991,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MHALACOG_01497	4.32e-233	yfiH	-	-	Q	ko:K05810	-	ko00000,ko01000	Multi-copper polyphenol oxidoreductase laccase
MHALACOG_01498	0.0	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase family U32 C-terminal domain
MHALACOG_01499	2.92e-192	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
MHALACOG_01500	2.92e-131	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Conserved hypothetical protein 95
MHALACOG_01501	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	helicase superfamily c-terminal domain
MHALACOG_01502	3.03e-40	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L28 family
MHALACOG_01503	2.45e-245	-	-	-	G	-	-	-	pfkB family carbohydrate kinase
MHALACOG_01504	3.65e-291	-	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	Vacuole effluxer Atg22 like
MHALACOG_01505	3.56e-89	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MHALACOG_01509	1.6e-111	ogt	2.1.1.63	-	L	ko:K00567,ko:K07443	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MHALACOG_01510	9.93e-304	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_01511	2.04e-169	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_01512	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Fumarase C C-terminus
MHALACOG_01513	1.64e-170	-	-	-	M	-	-	-	Mechanosensitive ion channel
MHALACOG_01514	1.44e-220	-	-	-	S	-	-	-	CAAX protease self-immunity
MHALACOG_01515	9.16e-272	-	-	-	E	ko:K02052	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
MHALACOG_01516	8.29e-175	-	-	-	U	ko:K02053	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01517	8.83e-198	-	-	-	U	ko:K02054	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01518	2.45e-268	-	-	-	P	ko:K02055	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01519	7.06e-292	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
MHALACOG_01520	3.11e-225	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
MHALACOG_01521	6.62e-231	plsC2	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Phosphate acyltransferases
MHALACOG_01522	1.33e-82	psp1	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	Endoribonuclease L-PSP
MHALACOG_01524	4.72e-153	-	-	-	S	-	-	-	CYTH
MHALACOG_01525	2.75e-219	ybbN	-	-	O	ko:K05838	-	ko00000,ko03110	Tetratricopeptide repeat
MHALACOG_01526	3.39e-230	-	-	-	-	-	-	-	-
MHALACOG_01527	1.86e-227	-	-	-	-	-	-	-	-
MHALACOG_01528	6.57e-205	-	5.2.1.8	-	M	ko:K01802	-	ko00000,ko01000	FKBP-type peptidyl-prolyl cis-trans isomerase
MHALACOG_01529	1.27e-174	nucS	-	-	L	ko:K07503	-	ko00000,ko01000	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MHALACOG_01530	4.39e-66	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
MHALACOG_01531	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MHALACOG_01532	1.78e-211	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MHALACOG_01533	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MHALACOG_01534	8.69e-193	atpH	-	-	C	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MHALACOG_01535	2.21e-104	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MHALACOG_01536	1.65e-40	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MHALACOG_01537	1.1e-191	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
MHALACOG_01539	6.18e-267	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MHALACOG_01541	0.0	-	-	-	K	-	-	-	RNA polymerase II activating transcription factor binding
MHALACOG_01542	0.0	glgE	2.4.99.16	GH13	G	ko:K16147	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB
MHALACOG_01543	2.37e-120	ppa	3.6.1.1	-	C	ko:K01507	ko00190,map00190	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MHALACOG_01544	8.16e-129	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MHALACOG_01545	1.72e-152	-	-	-	-	-	-	-	-
MHALACOG_01546	7.17e-180	glnR	-	-	KT	-	-	-	Transcriptional regulatory protein, C terminal
MHALACOG_01547	6.16e-168	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MHALACOG_01548	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
MHALACOG_01549	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MHALACOG_01550	0.0	-	-	-	S	-	-	-	domain protein
MHALACOG_01551	6.34e-81	tyrA	5.4.99.5	-	E	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase type II
MHALACOG_01552	0.0	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MHALACOG_01553	0.0	-	-	-	H	-	-	-	Flavin containing amine oxidoreductase
MHALACOG_01554	0.0	-	3.1.3.2, 3.6.1.27	-	I	ko:K09474,ko:K12685,ko:K19302	ko00550,ko00740,ko01100,ko02020,map00550,map00740,map01100,map02020	ko00000,ko00001,ko01000,ko01011,ko02000,ko02044	phosphatidate phosphatase activity
MHALACOG_01555	2.66e-68	-	-	-	S	-	-	-	Protein of unknown function (DUF2469)
MHALACOG_01556	7.62e-248	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MHALACOG_01557	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MHALACOG_01558	0.0	gatA	6.3.5.6, 6.3.5.7	-	F	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MHALACOG_01559	1.47e-67	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MHALACOG_01560	8.81e-204	trmH	2.1.1.34	-	J	ko:K00556	-	ko00000,ko01000,ko03016	RNA methyltransferase TrmH family
MHALACOG_01561	3.62e-128	pyrE1	-	-	F	-	-	-	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MHALACOG_01562	1.44e-299	rmuC	-	-	S	ko:K09760	-	ko00000	RmuC family
MHALACOG_01563	7.81e-56	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	Metal-sensitive transcriptional repressor
MHALACOG_01564	0.0	-	3.6.3.4, 3.6.3.54	-	P	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
MHALACOG_01565	6.87e-173	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
MHALACOG_01566	0.0	ptsP	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MHALACOG_01567	2.25e-54	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
MHALACOG_01569	1.41e-93	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
MHALACOG_01570	2.15e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MHALACOG_01571	2.88e-104	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-stranded DNA-binding protein
MHALACOG_01572	2.77e-64	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
MHALACOG_01573	6.5e-98	-	-	-	D	-	-	-	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MHALACOG_01574	3.76e-244	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MHALACOG_01575	6.43e-21	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01576	3.33e-140	pepE	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Peptidase family S51
MHALACOG_01577	3.27e-191	-	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MHALACOG_01578	0.0	-	-	-	S	ko:K03688	-	ko00000	ABC1 family
MHALACOG_01579	2.49e-53	-	-	-	S	-	-	-	granule-associated protein
MHALACOG_01580	9.83e-185	cobQ2	-	-	S	ko:K07009	-	ko00000	CobB/CobQ-like glutamine amidotransferase domain
MHALACOG_01581	0.0	murE	-	-	M	-	-	-	Domain of unknown function (DUF1727)
MHALACOG_01582	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
MHALACOG_01583	0.0	dinF	-	-	V	-	-	-	MatE
MHALACOG_01584	0.0	glnD	2.7.7.59	-	O	ko:K00990	ko02020,map02020	ko00000,ko00001,ko01000	Nucleotidyltransferase domain
MHALACOG_01585	7.34e-72	glnB	-	-	K	ko:K04751	ko02020,map02020	ko00000,ko00001	Nitrogen regulatory protein P-II
MHALACOG_01586	9.21e-304	amt	-	-	U	ko:K03320	-	ko00000,ko02000	Ammonium Transporter Family
MHALACOG_01587	2.34e-215	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MHALACOG_01588	2.48e-169	icaR	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_01589	1.86e-243	-	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	Glycosyltransferase like family 2
MHALACOG_01590	0.0	-	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Peptidase family C69
MHALACOG_01592	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MHALACOG_01593	1.53e-245	opcA	-	-	G	-	-	-	Glucose-6-phosphate dehydrogenase subunit
MHALACOG_01594	2.71e-197	pgl	3.1.1.31	-	G	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
MHALACOG_01595	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MHALACOG_01596	3.1e-305	-	-	-	S	-	-	-	Putative ABC-transporter type IV
MHALACOG_01597	0.0	-	-	-	S	ko:K01421	-	ko00000	YhgE Pip domain protein
MHALACOG_01598	0.0	-	-	-	S	ko:K01421	-	ko00000	YhgE Pip domain protein
MHALACOG_01599	1.16e-135	-	-	-	K	-	-	-	Psort location Cytoplasmic, score 8.87
MHALACOG_01600	8.26e-105	-	-	-	S	-	-	-	FMN_bind
MHALACOG_01601	8.04e-187	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MHALACOG_01602	2.47e-273	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
MHALACOG_01603	2.74e-286	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
MHALACOG_01604	1.08e-260	-	-	-	S	-	-	-	Predicted membrane protein (DUF2318)
MHALACOG_01605	4.64e-138	-	-	-	P	ko:K07230	-	ko00000,ko02000	Fe2+ transport protein
MHALACOG_01606	0.0	-	-	-	P	ko:K07243	-	ko00000,ko02000	Iron permease FTR1 family
MHALACOG_01610	4e-155	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
MHALACOG_01611	0.0	-	3.2.1.97	GH101	G	ko:K17624	-	ko00000,ko01000	Glycosyl hydrolase 101 beta sandwich domain
MHALACOG_01612	1.66e-53	-	-	-	-	-	-	-	-
MHALACOG_01615	0.0	gltX	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MHALACOG_01616	6.33e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
MHALACOG_01617	1.41e-153	-	5.1.3.15	-	G	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Aldose 1-epimerase
MHALACOG_01618	1.35e-158	-	-	-	-	-	-	-	-
MHALACOG_01619	2.15e-159	-	-	-	G	-	-	-	Phosphoglycerate mutase family
MHALACOG_01620	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MHALACOG_01621	3.69e-124	-	-	-	S	-	-	-	GtrA-like protein
MHALACOG_01622	9.13e-81	-	-	-	S	-	-	-	Macrophage migration inhibitory factor (MIF)
MHALACOG_01623	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Formate-tetrahydrofolate ligase
MHALACOG_01624	0.0	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Peptidase family C69
MHALACOG_01625	7.71e-138	-	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
MHALACOG_01626	6.34e-257	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
MHALACOG_01627	3.32e-131	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MHALACOG_01628	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MHALACOG_01629	3.97e-214	-	-	-	I	-	-	-	PAP2 superfamily
MHALACOG_01630	0.0	pbp5	-	-	M	-	-	-	Transglycosylase
MHALACOG_01631	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MHALACOG_01632	8.17e-311	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
MHALACOG_01633	0.000837	-	-	-	-	-	-	-	-
MHALACOG_01634	1.03e-146	-	-	-	-	-	-	-	-
MHALACOG_01635	1.79e-267	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MHALACOG_01636	3.91e-124	ask	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	ACT domain
MHALACOG_01637	5.79e-170	ask	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
MHALACOG_01638	2.75e-208	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01639	6.44e-263	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
MHALACOG_01640	1.93e-139	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MHALACOG_01641	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III subunit gamma tau
MHALACOG_01642	6.98e-137	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_01643	2.42e-262	-	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Diacylglycerol kinase catalytic domain protein
MHALACOG_01644	2.99e-68	-	-	-	S	-	-	-	TIGRFAM helicase secretion neighborhood TadE-like protein
MHALACOG_01645	5.03e-53	-	-	-	S	-	-	-	Protein of unknown function (DUF4244)
MHALACOG_01646	1.57e-129	-	-	-	NU	-	-	-	Type II secretion system (T2SS), protein F
MHALACOG_01647	4.1e-143	-	-	-	U	ko:K12510	-	ko00000,ko02044	Type ii secretion system
MHALACOG_01648	3.91e-246	cpaF	-	-	U	ko:K02283	-	ko00000,ko02035,ko02044	Type II IV secretion system protein
MHALACOG_01649	8.52e-160	-	-	-	D	-	-	-	bacterial-type flagellum organization
MHALACOG_01650	3.02e-170	dedA1	-	-	S	ko:K03975	-	ko00000	SNARE associated Golgi protein
MHALACOG_01651	1.57e-163	-	-	-	S	-	-	-	HAD hydrolase, family IA, variant 3
MHALACOG_01652	7.9e-182	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Oxidoreductase, short chain dehydrogenase reductase family protein
MHALACOG_01653	5e-293	-	-	-	C	-	-	-	Acyl-CoA reductase (LuxC)
MHALACOG_01654	8.71e-263	-	-	-	H	-	-	-	long-chain-fatty-acid--luciferin-component ligase, acyl-protein synthase
MHALACOG_01655	2.88e-270	-	-	-	F	-	-	-	Psort location CytoplasmicMembrane, score 10.00
MHALACOG_01656	4.55e-131	hspR	-	-	K	ko:K13640	-	ko00000,ko03000	transcriptional regulator, MerR family
MHALACOG_01657	1.28e-232	dnaJ	-	-	O	ko:K03686,ko:K05516	-	ko00000,ko03029,ko03036,ko03110	DnaJ molecular chaperone homology domain
MHALACOG_01658	7.76e-90	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MHALACOG_01659	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
MHALACOG_01661	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
MHALACOG_01662	6.53e-72	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01663	2.4e-157	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01664	3.06e-54	-	3.2.1.1, 3.2.1.41	CBM48,GH13	M	ko:K01176,ko:K01200	ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973	ko00000,ko00001,ko01000	Aamy_C
MHALACOG_01665	7.37e-31	malL	2.4.1.4, 3.2.1.1, 3.2.1.20, 5.4.99.16	GH13,GH31	G	ko:K01187,ko:K05341,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha-amylase domain
MHALACOG_01666	0.0	malQ	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
MHALACOG_01667	4.3e-233	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01668	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha-amylase domain
MHALACOG_01669	5.06e-260	ilvC	1.1.1.86	-	H	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MHALACOG_01670	8.04e-257	ilvC	1.1.1.86	-	H	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MHALACOG_01671	0.0	-	-	-	EGP	-	-	-	Sugar (and other) transporter
MHALACOG_01672	2.65e-204	-	-	-	K	ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MHALACOG_01673	0.0	scrT	-	-	G	-	-	-	Transporter major facilitator family protein
MHALACOG_01674	0.0	gtfA	2.4.1.7	GH13	G	ko:K00690	ko00500,map00500	ko00000,ko00001,ko01000	Domain of unknown function (DUF1964)
MHALACOG_01675	5.12e-305	-	-	-	L	-	-	-	PFAM Integrase catalytic
MHALACOG_01676	6.35e-107	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
MHALACOG_01677	1.46e-240	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01678	0.0	-	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	arabinose metabolic process
MHALACOG_01679	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
MHALACOG_01680	3.05e-136	-	-	-	L	-	-	-	Transposase and inactivated derivatives
MHALACOG_01681	9.59e-39	-	-	-	L	ko:K07483	-	ko00000	transposase activity
MHALACOG_01682	1.39e-195	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
MHALACOG_01683	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MHALACOG_01684	8.45e-241	fbaA	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
MHALACOG_01686	2.6e-209	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
MHALACOG_01687	0.0	fprA	1.18.1.2, 1.19.1.1	-	C	ko:K00528	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase
MHALACOG_01688	1.12e-170	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01689	0.0	-	3.6.3.4, 3.6.3.54	-	P	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
MHALACOG_01690	0.0	degP	-	-	O	ko:K08372	ko02020,map02020	ko00000,ko00001,ko01000,ko01002	Domain present in PSD-95, Dlg, and ZO-1/2.
MHALACOG_01691	0.0	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MHALACOG_01694	9.66e-179	-	-	-	S	ko:K11068	-	ko00000,ko02042	Haemolysin-III related
MHALACOG_01695	2.9e-68	-	-	-	S	-	-	-	Putative heavy-metal-binding
MHALACOG_01696	4.71e-98	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
MHALACOG_01697	0.0	-	-	-	KL	-	-	-	Domain of unknown function (DUF3427)
MHALACOG_01698	1.03e-11	-	-	-	S	ko:K07005	-	ko00000	Pyridoxamine 5'-phosphate oxidase
MHALACOG_01699	9.19e-243	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MHALACOG_01700	0.0	lysX	-	-	S	-	-	-	Uncharacterised conserved protein (DUF2156)
MHALACOG_01701	5.08e-261	-	-	-	S	-	-	-	Putative esterase
MHALACOG_01702	1.2e-39	-	-	-	-	-	-	-	-
MHALACOG_01703	3.48e-219	-	-	-	EG	-	-	-	EamA-like transporter family
MHALACOG_01704	4.94e-119	-	-	-	O	-	-	-	Hsp20/alpha crystallin family
MHALACOG_01705	2.27e-146	-	-	-	P	-	-	-	Toxic anion resistance protein (TelA)
MHALACOG_01706	3.84e-74	-	-	-	-	-	-	-	-
MHALACOG_01707	1.92e-59	-	-	-	-	-	-	-	-
MHALACOG_01708	3.59e-217	-	-	-	P	ko:K07114	-	ko00000,ko02000	von Willebrand factor type A domain
MHALACOG_01709	1.67e-270	pldB	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Serine aminopeptidase, S33
MHALACOG_01710	0.0	pepX	3.4.14.5	-	E	ko:K01278	ko04974,map04974	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	Dipeptidyl peptidase IV (DPP IV) N-terminal region
MHALACOG_01711	6.12e-166	fhaA	-	-	T	-	-	-	Protein of unknown function (DUF2662)
MHALACOG_01712	8.5e-88	fhaB	-	-	T	-	-	-	Inner membrane component of T3SS, cytoplasmic domain
MHALACOG_01713	0.0	pstP	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	Sigma factor PP2C-like phosphatases
MHALACOG_01714	0.0	rodA	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MHALACOG_01715	0.0	pbpA	-	-	M	ko:K05364	ko00550,map00550	ko00000,ko00001,ko01011	penicillin-binding protein
MHALACOG_01716	1.13e-223	pknA	2.7.11.1	-	T	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	Protein tyrosine kinase
MHALACOG_01717	0.0	pknB	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	Protein tyrosine kinase
MHALACOG_01718	3.42e-149	trpG	2.6.1.85, 4.1.3.27	-	EH	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	para-aminobenzoate synthase glutamine amidotransferase component II
MHALACOG_01719	2.14e-297	srtB	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
MHALACOG_01720	2.93e-169	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF881)
MHALACOG_01721	2.89e-104	crgA	-	-	D	-	-	-	Involved in cell division
MHALACOG_01722	4.09e-163	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Rhomboid family
MHALACOG_01723	6.91e-45	-	-	-	-	-	-	-	-
MHALACOG_01724	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MHALACOG_01725	7.48e-96	-	-	-	I	-	-	-	Sterol carrier protein
MHALACOG_01726	6.74e-61	-	-	-	S	-	-	-	Protein of unknown function (DUF3073)
MHALACOG_01727	5.93e-261	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
MHALACOG_01728	0.0	-	-	-	S	-	-	-	Amidohydrolase family
MHALACOG_01729	3.71e-235	-	-	-	S	-	-	-	Protein conserved in bacteria
MHALACOG_01730	0.0	-	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MHALACOG_01731	0.0	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
MHALACOG_01732	0.0	ppc	4.1.1.31	-	H	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MHALACOG_01733	2.69e-230	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01734	4.4e-305	-	-	-	EGP	ko:K08177	-	ko00000,ko02000	Major Facilitator Superfamily
MHALACOG_01735	0.0	-	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Thioredoxin domain
MHALACOG_01736	8.31e-139	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
MHALACOG_01737	5.21e-155	cah	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
MHALACOG_01738	2.75e-304	-	-	-	P	ko:K03699	-	ko00000,ko02042	Transporter associated domain
MHALACOG_01739	1.09e-109	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
MHALACOG_01740	0.0	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01741	2.56e-83	gntK	2.7.1.12, 2.7.1.71	-	F	ko:K00851,ko:K00891	ko00030,ko00400,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00400,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Shikimate kinase
MHALACOG_01742	1.45e-189	-	-	-	S	ko:K07043	-	ko00000	Protein of unknown function DUF45
MHALACOG_01743	4.23e-206	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01744	1.96e-19	-	-	-	L	ko:K07485	-	ko00000	Transposase
MHALACOG_01748	8.12e-15	-	-	-	-	-	-	-	-
MHALACOG_01749	1.66e-248	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
MHALACOG_01750	2.61e-314	-	2.6.1.1, 2.6.1.2, 2.6.1.66	-	E	ko:K00812,ko:K10907,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
MHALACOG_01751	2.88e-91	lrp_3	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	helix_turn_helix ASNC type
MHALACOG_01752	0.0	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MHALACOG_01753	9.36e-25	-	-	-	G	-	-	-	Pectinesterase
MHALACOG_01755	2.14e-112	-	-	-	S	-	-	-	Transmembrane domain of unknown function (DUF3566)
MHALACOG_01756	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MHALACOG_01757	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MHALACOG_01758	8.05e-106	-	-	-	S	-	-	-	Protein of unknown function (DUF721)
MHALACOG_01759	6.73e-285	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MHALACOG_01760	1.52e-264	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MHALACOG_01761	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MHALACOG_01762	6.56e-20	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
MHALACOG_01763	1e-45	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MHALACOG_01764	1.54e-226	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Membrane protein insertase, YidC Oxa1 family
MHALACOG_01765	1.06e-118	jag	-	-	S	ko:K06346	-	ko00000	Putative single-stranded nucleic acids-binding domain
MHALACOG_01766	5.91e-158	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
MHALACOG_01767	1.23e-226	parA	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	CobQ CobB MinD ParA nucleotide binding domain protein
MHALACOG_01768	1.17e-292	parB	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
MHALACOG_01769	8.72e-235	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MHALACOG_01770	0.0	-	-	-	KLT	ko:K03980	-	ko00000,ko01011,ko02000	MviN-like protein
MHALACOG_01771	1.53e-270	mviN	-	-	KLT	ko:K03980	-	ko00000,ko01011,ko02000	MviN-like protein
MHALACOG_01772	0.0	-	-	-	-	-	-	-	-
MHALACOG_01773	1.66e-262	mutT4	-	-	L	-	-	-	Belongs to the Nudix hydrolase family
MHALACOG_01774	0.0	pcnA	2.7.7.19, 2.7.7.72	-	J	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	Probable RNA and SrmB- binding site of polymerase A
MHALACOG_01775	3.83e-139	-	-	-	S	-	-	-	LytR cell envelope-related transcriptional attenuator
MHALACOG_01776	2.1e-219	ispE	2.7.1.148	-	F	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MHALACOG_01777	5.52e-213	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MHALACOG_01778	8.69e-279	rpfB	-	-	S	ko:K21688	-	ko00000	G5
MHALACOG_01780	3.21e-191	-	-	-	O	-	-	-	Thioredoxin
MHALACOG_01781	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
MHALACOG_01782	8.55e-55	-	3.2.1.21	GH3	G	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Fibronectin type III-like domain
MHALACOG_01783	8.76e-261	-	-	-	S	-	-	-	AAA ATPase domain
MHALACOG_01784	3.19e-159	-	-	-	U	ko:K10716	-	ko00000,ko02000	Ion channel
MHALACOG_01785	4.82e-155	-	-	-	S	-	-	-	Protein of unknown function (DUF3990)
MHALACOG_01786	1.24e-152	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MHALACOG_01787	1.62e-57	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
MHALACOG_01788	5.09e-107	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
MHALACOG_01789	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MHALACOG_01791	2.09e-242	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MHALACOG_01792	3.68e-276	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MHALACOG_01793	2.97e-267	ugpC	-	-	E	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MHALACOG_01794	0.0	-	-	-	S	-	-	-	LPXTG-motif cell wall anchor domain protein
MHALACOG_01795	3.21e-301	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
MHALACOG_01796	2.38e-226	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
MHALACOG_01797	2.19e-138	-	-	-	-	-	-	-	-
MHALACOG_01798	1.76e-39	-	-	-	-	-	-	-	-
MHALACOG_01799	0.0	-	-	-	KLT	-	-	-	Domain of unknown function (DUF4032)
MHALACOG_01800	7.89e-222	rlmB	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MHALACOG_01801	1.64e-284	-	-	-	EGP	-	-	-	Transmembrane secretion effector
MHALACOG_01802	1.02e-149	-	-	-	I	-	-	-	alpha/beta hydrolase fold
MHALACOG_01803	0.0	pacL2	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
MHALACOG_01804	1.09e-163	-	-	-	-	-	-	-	-
MHALACOG_01805	4.97e-143	dcd	3.5.4.13	-	F	ko:K01494	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dCTP deaminase family
MHALACOG_01806	1.45e-176	-	-	-	-	-	-	-	-
MHALACOG_01807	6.17e-189	-	-	-	S	ko:K06999	-	ko00000	Phospholipase/Carboxylesterase
MHALACOG_01808	0.0	nhaP	-	-	P	ko:K03316	-	ko00000	Sodium/hydrogen exchanger family
MHALACOG_01809	2.35e-106	tadA	3.5.4.1, 3.5.4.33	-	FJ	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MHALACOG_01810	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Glycosyl hydrolase family 36 N-terminal domain
MHALACOG_01811	5.56e-288	-	-	-	GK	-	-	-	ROK family
MHALACOG_01812	8.96e-310	-	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01813	6.52e-199	-	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01814	3.04e-198	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01815	6.06e-12	-	-	-	L	-	-	-	Transposase
MHALACOG_01816	0.0	-	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
MHALACOG_01817	2.14e-297	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
MHALACOG_01818	6.67e-188	cobB2	-	-	K	ko:K12410	-	ko00000,ko01000	Sir2 family
MHALACOG_01821	1.86e-210	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_01822	0.0	-	-	-	S	ko:K01421	-	ko00000	YhgE Pip domain protein
MHALACOG_01823	0.0	-	-	-	S	ko:K01421	-	ko00000	YhgE Pip domain protein
MHALACOG_01824	5.43e-180	nfrA	-	-	C	-	-	-	Nitroreductase family
MHALACOG_01825	2.73e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF4235)
MHALACOG_01826	1.77e-176	gpm2	3.1.3.73	-	G	ko:K02226	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Phosphoglycerate mutase family
MHALACOG_01827	0.0	amyE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01828	4.67e-234	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
MHALACOG_01829	2.71e-199	msmF	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01830	7.45e-195	-	-	-	G	ko:K02026,ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
MHALACOG_01831	7.18e-131	-	-	-	S	-	-	-	Protein of unknown function, DUF624
MHALACOG_01832	0.0	-	-	-	N	-	-	-	Bacterial Ig-like domain 2
MHALACOG_01833	3.57e-190	-	-	-	L	-	-	-	Transposase
MHALACOG_01834	1.41e-31	-	-	-	L	-	-	-	Transposase
MHALACOG_01835	0.0	-	-	-	S	ko:K06921	-	ko00000	ATPase domain predominantly from Archaea
MHALACOG_01836	0.0	aroP	-	-	E	ko:K03293,ko:K11732	-	ko00000,ko02000	aromatic amino acid transport protein AroP K03293
MHALACOG_01837	7.92e-129	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
MHALACOG_01838	1.76e-165	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
MHALACOG_01839	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
MHALACOG_01840	0.0	-	-	-	E	ko:K03293	-	ko00000	Amino acid permease
MHALACOG_01841	0.0	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative DNA-binding domain
MHALACOG_01842	0.0	-	-	-	M	-	-	-	F5/8 type C domain
MHALACOG_01843	0.0	-	-	-	M	-	-	-	Belongs to the glycosyl hydrolase 30 family
MHALACOG_01844	1.57e-60	-	-	-	S	ko:K14623	-	ko00000,ko03400	SOS response
MHALACOG_01845	2.15e-116	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MHALACOG_01846	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
MHALACOG_01847	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter transmembrane region
MHALACOG_01848	4.38e-223	-	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
MHALACOG_01849	1.27e-308	-	-	-	G	-	-	-	MFS/sugar transport protein
MHALACOG_01851	1.2e-232	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MHALACOG_01852	4.89e-146	-	-	-	-	-	-	-	-
MHALACOG_01853	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MHALACOG_01855	4.62e-82	-	-	-	S	-	-	-	Protein conserved in bacteria
MHALACOG_01856	1.55e-112	-	-	-	S	-	-	-	Protein conserved in bacteria
MHALACOG_01857	0.0	-	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
MHALACOG_01858	9.14e-263	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_01859	0.0	-	-	-	S	ko:K09955	-	ko00000	Beta-L-arabinofuranosidase, GH127
MHALACOG_01860	9.12e-145	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
MHALACOG_01861	1.22e-199	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01862	0.0	-	-	-	G	-	-	-	Alpha galactosidase A
MHALACOG_01863	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MHALACOG_01864	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MHALACOG_01865	0.0	-	-	-	G	-	-	-	Alpha-L-arabinofuranosidase C-terminus
MHALACOG_01866	1.98e-09	-	-	-	-	-	-	-	-
MHALACOG_01867	0.0	-	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	C-terminal of Glycosyl hydrolases family 43
MHALACOG_01868	0.0	-	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	C-terminal of Glycosyl hydrolases family 43
MHALACOG_01869	0.0	-	-	-	G	-	-	-	Glycosyl hydrolases family 43
MHALACOG_01870	4.66e-209	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
MHALACOG_01871	1.69e-105	-	-	-	I	-	-	-	alpha/beta hydrolase fold
MHALACOG_01872	6.85e-249	-	-	-	G	-	-	-	Glycosyl hydrolases family 43
MHALACOG_01873	2.02e-306	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
MHALACOG_01874	1.98e-211	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01875	5.8e-174	-	-	-	U	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MHALACOG_01876	3.53e-23	-	-	-	G	ko:K16210	-	ko00000,ko02000	MFS/sugar transport protein
MHALACOG_01877	3.11e-248	-	-	-	S	-	-	-	Fic/DOC family
MHALACOG_01878	1.57e-236	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
MHALACOG_01879	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
MHALACOG_01880	9.19e-208	-	-	-	S	-	-	-	Glutamine amidotransferase domain
MHALACOG_01881	3.86e-174	-	-	-	T	ko:K06950	-	ko00000	HD domain
MHALACOG_01882	4.73e-247	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
MHALACOG_01883	4.19e-316	-	-	-	V	-	-	-	ABC transporter permease
MHALACOG_01884	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF4012)
MHALACOG_01885	1.3e-257	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
MHALACOG_01886	5.01e-67	-	-	-	L	ko:K07485	-	ko00000	Transposase
MHALACOG_01887	3.67e-21	-	-	-	S	ko:K07133	-	ko00000	Domain of unknown function (DUF4143)
MHALACOG_01888	0.0	-	-	-	M	-	-	-	Psort location CytoplasmicMembrane, score 9.26
MHALACOG_01889	1.17e-137	-	-	-	M	-	-	-	Glycosyl transferase family 2
MHALACOG_01890	4.08e-200	-	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferase family 2
MHALACOG_01891	1.88e-206	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal
MHALACOG_01892	5.31e-212	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
MHALACOG_01893	4.15e-49	-	-	-	-	-	-	-	-
MHALACOG_01894	1.94e-195	-	-	-	M	-	-	-	Glycosyl transferase family 2
MHALACOG_01895	2.52e-25	-	-	-	-	-	-	-	-
MHALACOG_01896	0.0	-	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferase family 2
MHALACOG_01897	2.31e-260	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MHALACOG_01898	0.0	rfbD	1.1.1.133, 5.1.3.13	-	M	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MHALACOG_01899	9.62e-194	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MHALACOG_01900	4.05e-140	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MHALACOG_01901	3.12e-316	-	-	-	M	ko:K07272	-	ko00000,ko01000,ko01003,ko01005	Rhamnan synthesis protein F
MHALACOG_01902	8.9e-156	tagG	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
MHALACOG_01903	1.03e-228	-	-	-	GM	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MHALACOG_01904	3.55e-29	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MHALACOG_01905	4.85e-254	ugd	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	UDP binding domain
MHALACOG_01906	3.36e-46	-	-	-	M	-	-	-	Psort location CytoplasmicMembrane, score 9.26
MHALACOG_01907	0.000176	-	-	-	S	-	-	-	enterobacterial common antigen metabolic process
MHALACOG_01908	6.14e-208	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MHALACOG_01909	2.05e-290	glf	5.4.99.9	-	M	ko:K01854	ko00052,ko00520,map00052,map00520	ko00000,ko00001,ko01000	UDP-galactopyranose mutase
MHALACOG_01910	1.47e-35	-	-	-	S	-	-	-	Domain of unknown function (DUF4190)
MHALACOG_01911	4.2e-202	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
MHALACOG_01912	1.29e-26	-	-	-	S	ko:K07088	-	ko00000	Auxin Efflux Carrier
MHALACOG_01913	7.21e-203	-	-	-	K	-	-	-	helix_turn_helix isocitrate lyase regulation
MHALACOG_01914	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Aromatic amino acid lyase
MHALACOG_01915	0.0	clpB	-	-	O	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	ko00000,ko00001,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
MHALACOG_01916	1.44e-280	gluQ	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
MHALACOG_01917	1.55e-275	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
MHALACOG_01918	6.08e-107	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MHALACOG_01919	5.48e-150	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MHALACOG_01920	0.0	-	-	-	S	ko:K07133	-	ko00000	Psort location Cytoplasmic, score
MHALACOG_01921	1.64e-174	-	-	-	-	-	-	-	-
MHALACOG_01922	2.05e-277	mutT	3.6.1.55	-	LT	ko:K03574	-	ko00000,ko01000,ko03400	Phosphoglycerate mutase family
MHALACOG_01923	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MHALACOG_01924	9.15e-308	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
MHALACOG_01925	1.55e-180	ltbR	-	-	K	-	-	-	Transcriptional regulator, IclR family, C-terminal domain protein
MHALACOG_01926	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MHALACOG_01927	2.61e-170	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MHALACOG_01928	1.6e-271	pyr	1.3.98.1	-	F	ko:K00226	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroorotate dehydrogenase
MHALACOG_01929	0.0	nox	-	-	C	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
MHALACOG_01930	0.0	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MHALACOG_01931	8.23e-309	-	4.4.1.8	-	E	ko:K00842,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I II
MHALACOG_01932	3.24e-220	-	-	-	K	-	-	-	LysR substrate binding domain protein
MHALACOG_01933	6.56e-252	-	-	-	G	-	-	-	Transmembrane secretion effector
MHALACOG_01934	1.68e-133	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MHALACOG_01935	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
MHALACOG_01936	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MHALACOG_01937	4.08e-306	hom	1.1.1.3, 2.7.2.4	-	E	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
MHALACOG_01938	2.31e-257	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MHALACOG_01939	0.0	maf	-	-	DF	ko:K06287	-	ko00000	Maf-like protein
MHALACOG_01940	3.14e-11	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
MHALACOG_01941	2.92e-23	-	-	-	S	-	-	-	Protein of unknown function (DUF1778)
MHALACOG_01943	2.68e-196	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MHALACOG_01944	4.75e-286	-	-	-	V	-	-	-	Efflux ABC transporter, permease protein
MHALACOG_01945	5.29e-212	-	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
MHALACOG_01946	2.01e-291	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Peptidase dimerisation domain
MHALACOG_01947	0.0	rne	3.1.26.12	-	J	ko:K08300,ko:K08301	ko03018,map03018	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	Ribonuclease E/G family
MHALACOG_01948	3.4e-61	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
MHALACOG_01949	3.99e-53	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L27 protein
MHALACOG_01950	0.0	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MHALACOG_01951	5.06e-260	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MHALACOG_01952	1.6e-291	aspC	2.6.1.1, 2.6.1.2, 2.6.1.66	-	E	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
MHALACOG_01954	3.36e-42	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MHALACOG_01955	1.78e-190	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
MHALACOG_01956	4.11e-95	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MHALACOG_01957	1.75e-159	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MHALACOG_01959	7.49e-198	-	-	-	K	-	-	-	Bacterial transcriptional regulator
MHALACOG_01960	3.13e-172	-	-	-	K	-	-	-	Sugar-specific transcriptional regulator TrmB
MHALACOG_01961	6.51e-179	-	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
MHALACOG_01962	0.0	-	-	-	-	-	-	-	-
MHALACOG_01963	2.25e-190	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Biotin/lipoate A/B protein ligase family
MHALACOG_01964	1.67e-119	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
MHALACOG_01965	0.0	accC	6.3.4.14, 6.4.1.2, 6.4.1.3	-	I	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase L chain, ATP binding domain protein
MHALACOG_01966	0.0	pccB	-	-	I	-	-	-	Carboxyl transferase domain
MHALACOG_01967	0.0	fas	-	-	I	ko:K11533	ko00061,ko01100,ko01212,ko04931,map00061,map01100,map01212,map04931	ko00000,ko00001,ko00002,ko01000,ko01004	Beta-ketoacyl synthase, C-terminal domain
MHALACOG_01968	7.4e-126	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MHALACOG_01969	1.16e-35	dexB	2.4.1.7, 3.2.1.20, 3.2.1.51, 3.2.1.70, 3.2.1.93, 3.2.1.97	GH101,GH13,GH29,GH31	G	ko:K00690,ko:K01187,ko:K01206,ko:K01215,ko:K01226,ko:K17624	ko00052,ko00500,ko00511,ko01100,map00052,map00500,map00511,map01100	ko00000,ko00001,ko01000,ko04147	hydrolase activity, hydrolyzing O-glycosyl compounds
MHALACOG_01971	8.81e-107	-	-	-	M	-	-	-	Conserved repeat domain
MHALACOG_01972	6.73e-26	-	-	-	M	-	-	-	domain protein
MHALACOG_01973	2.51e-71	-	-	-	-	-	-	-	-
MHALACOG_01974	5.54e-146	-	-	-	-	-	-	-	-
MHALACOG_01975	4.46e-254	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
MHALACOG_01976	1.22e-212	-	3.2.1.55	CBM6,GH43	G	ko:K15921	ko00520,map00520	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
MHALACOG_01977	1.77e-261	-	-	-	G	-	-	-	Glycosyl hydrolases family 43
MHALACOG_01978	3.27e-95	-	-	-	-	-	-	-	-
MHALACOG_01979	3.82e-52	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MHALACOG_01980	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MHALACOG_01981	1.11e-314	-	-	-	S	ko:K06901	-	ko00000,ko02000	Permease family
MHALACOG_01982	1.16e-180	-	-	-	S	-	-	-	alpha beta
MHALACOG_01983	2.41e-113	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MHALACOG_01984	4.27e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MHALACOG_01985	5.53e-273	-	-	-	T	-	-	-	Forkhead associated domain
MHALACOG_01986	0.0	-	-	-	L	-	-	-	Superfamily I DNA and RNA helicases and helicase subunits
MHALACOG_01987	1.72e-40	-	-	-	-	-	-	-	-
MHALACOG_01988	7.65e-116	-	-	-	NO	-	-	-	SAF
MHALACOG_01989	1.79e-42	-	-	-	S	-	-	-	Putative regulatory protein
MHALACOG_01990	4.5e-152	ygfA	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	5-formyltetrahydrofolate cyclo-ligase family
MHALACOG_01991	3.86e-163	rimJ	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
MHALACOG_01992	8.24e-242	-	-	-	-	-	-	-	-
MHALACOG_01993	6.02e-64	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MHALACOG_01994	1.31e-85	megL	4.4.1.11	-	E	ko:K01761	ko00270,ko00450,map00270,map00450	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
MHALACOG_01998	1.03e-34	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L33
MHALACOG_01999	2.63e-284	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
MHALACOG_02000	0.0	-	-	-	E	ko:K03294	-	ko00000	aromatic amino acid transport protein AroP K03293
MHALACOG_02001	2.23e-79	fdxA	-	-	C	ko:K05524	-	ko00000	4Fe-4S binding domain
MHALACOG_02002	1.78e-284	dapC	-	-	E	-	-	-	Aminotransferase class I and II
MHALACOG_02003	5.95e-301	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MHALACOG_02004	1.99e-212	-	-	-	S	ko:K11939	-	ko00000,ko02000	EamA-like transporter family
MHALACOG_02006	0.0	-	-	-	M	ko:K07282	-	ko00000	Bacterial capsule synthesis protein PGA_cap
MHALACOG_02007	1.04e-246	pdxB	-	-	EH	-	-	-	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MHALACOG_02008	3.27e-142	yigZ	-	-	S	-	-	-	Uncharacterized protein family UPF0029
MHALACOG_02009	4.95e-147	-	-	-	-	-	-	-	-
MHALACOG_02010	0.0	malQ	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
MHALACOG_02011	1.86e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MHALACOG_02012	9.6e-106	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
MHALACOG_02013	0.0	glgX	3.2.1.196, 3.2.1.68	CBM48,GH13	G	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 13 family
MHALACOG_02014	3.92e-290	-	-	-	GK	-	-	-	transcriptional repressor of nag (N-acetylglucosamine) operon K02565
MHALACOG_02015	0.0	adhE	1.1.1.1, 1.2.1.10, 1.2.1.81	-	C	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
MHALACOG_02016	3.04e-201	-	-	-	S	-	-	-	YwiC-like protein
MHALACOG_02017	9.35e-68	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
MHALACOG_02018	1.11e-149	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MHALACOG_02019	1.97e-150	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
MHALACOG_02020	8.86e-62	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MHALACOG_02021	2.23e-194	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MHALACOG_02022	1.4e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MHALACOG_02023	1.55e-74	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MHALACOG_02024	1.32e-161	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MHALACOG_02025	6.4e-97	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MHALACOG_02026	1.97e-49	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
MHALACOG_02027	1.11e-54	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MHALACOG_02028	2.55e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MHALACOG_02029	1.09e-68	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MHALACOG_02030	2.77e-134	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MHALACOG_02031	7.06e-40	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MHALACOG_02032	3.17e-90	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MHALACOG_02033	6.34e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MHALACOG_02034	1.79e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MHALACOG_02035	4.66e-127	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MHALACOG_02036	4.64e-36	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30p/L7e
MHALACOG_02037	1.52e-98	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MHALACOG_02038	6.89e-313	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MHALACOG_02039	1.49e-127	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MHALACOG_02040	6.91e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MHALACOG_02041	1.47e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
MHALACOG_02042	1.16e-81	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MHALACOG_02043	4.12e-53	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MHALACOG_02044	2.55e-26	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MHALACOG_02045	1.66e-12	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
MHALACOG_02046	6.48e-38	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs