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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
MDDHOLLC_00010	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_00011	9.88e-125	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter protein (Thia_YuaJ)
MDDHOLLC_00012	1.25e-276	yuaG	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	protein conserved in bacteria
MDDHOLLC_00013	5.61e-109	yuaF	-	-	OU	-	-	-	Membrane protein implicated in regulation of membrane protease activity
MDDHOLLC_00014	2.16e-33	yuaE	-	-	S	-	-	-	DinB superfamily
MDDHOLLC_00015	6.19e-56	yuaE	-	-	S	-	-	-	DinB superfamily
MDDHOLLC_00016	6.79e-141	-	-	-	S	-	-	-	MOSC domain
MDDHOLLC_00017	1.74e-290	gbsB	1.1.1.1	-	C	ko:K11440	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
MDDHOLLC_00018	0.0	gbsA	1.2.1.8	-	C	ko:K00130	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MDDHOLLC_00019	1.67e-123	yuaC	-	-	K	ko:K22109	-	ko00000,ko03000	Belongs to the GbsR family
MDDHOLLC_00020	4.1e-122	yuaB	-	-	-	-	-	-	-
MDDHOLLC_00021	1.76e-155	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
MDDHOLLC_00022	8.63e-190	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MDDHOLLC_00023	4.34e-280	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MDDHOLLC_00024	8.44e-154	-	-	-	G	-	-	-	Cupin
MDDHOLLC_00025	1.71e-65	yjcN	-	-	-	-	-	-	-
MDDHOLLC_00029	1.43e-175	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Aspartate phosphatase response regulator
MDDHOLLC_00031	8.59e-19	-	-	-	-	-	-	-	-
MDDHOLLC_00035	6.56e-187	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MDDHOLLC_00036	5.75e-250	yubA	-	-	S	-	-	-	transporter activity
MDDHOLLC_00037	3.87e-237	yulF	-	-	S	ko:K22230	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
MDDHOLLC_00038	6.95e-127	yraA	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
MDDHOLLC_00039	0.0	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MDDHOLLC_00040	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MDDHOLLC_00041	0.0	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MDDHOLLC_00042	4.4e-316	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MDDHOLLC_00043	6.36e-179	tgl	2.3.2.13	-	H	ko:K00686	-	ko00000,ko01000	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
MDDHOLLC_00044	9.36e-55	-	-	-	-	-	-	-	-
MDDHOLLC_00045	1.16e-241	npd	1.13.12.16	-	S	ko:K00459	ko00910,map00910	ko00000,ko00001,ko01000	COG2070 Dioxygenases related to 2-nitropropane dioxygenase
MDDHOLLC_00046	1.05e-95	yugU	-	-	S	-	-	-	Uncharacterised protein family UPF0047
MDDHOLLC_00047	0.0	yugT	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
MDDHOLLC_00048	7.73e-295	yugS	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MDDHOLLC_00049	1.67e-150	yugP	-	-	S	ko:K06973	-	ko00000	Zn-dependent protease
MDDHOLLC_00050	3.06e-23	-	-	-	-	-	-	-	-
MDDHOLLC_00051	3.47e-35	mstX	-	-	S	-	-	-	Membrane-integrating protein Mistic
MDDHOLLC_00052	2.8e-230	yugO	-	-	P	ko:K10716	-	ko00000,ko02000	COG1226 Kef-type K transport systems
MDDHOLLC_00053	1.17e-92	yugN	-	-	S	-	-	-	YugN-like family
MDDHOLLC_00055	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
MDDHOLLC_00056	1.8e-129	-	-	-	S	ko:K19784	-	ko00000	NADPH-dependent FMN reductase
MDDHOLLC_00057	1.51e-144	ycaC	-	-	Q	-	-	-	Isochorismatase family
MDDHOLLC_00058	9.22e-290	yugK	-	-	C	ko:K19955	-	ko00000,ko01000	Dehydrogenase
MDDHOLLC_00059	3.88e-285	yugJ	-	-	C	ko:K19955	-	ko00000,ko01000	oxidoreductases, Fe-dependent alcohol dehydrogenase family
MDDHOLLC_00060	3.14e-46	yuzA	-	-	S	ko:K09779	-	ko00000	Domain of unknown function (DUF378)
MDDHOLLC_00061	1.43e-82	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
MDDHOLLC_00062	6.82e-266	yugH	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Aminotransferase
MDDHOLLC_00063	3.75e-109	alaR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00064	4.71e-199	yugF	-	-	I	-	-	-	Hydrolase
MDDHOLLC_00065	4.25e-55	yugE	-	-	S	-	-	-	Domain of unknown function (DUF1871)
MDDHOLLC_00066	3.19e-284	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
MDDHOLLC_00067	8.61e-291	kinB2	2.7.13.3	-	T	ko:K07697	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00068	3.28e-87	kapB	-	-	G	ko:K06347	ko02020,map02020	ko00000,ko00001	Kinase associated protein B
MDDHOLLC_00069	2.64e-153	kapD	-	-	L	ko:K06348	-	ko00000	the KinA pathway to sporulation
MDDHOLLC_00070	2.25e-264	yuxJ	-	-	EGP	-	-	-	Major facilitator superfamily
MDDHOLLC_00071	2.92e-158	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
MDDHOLLC_00072	8.63e-283	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
MDDHOLLC_00073	2.62e-95	yuxK	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00074	1.6e-101	yufK	-	-	S	-	-	-	Family of unknown function (DUF5366)
MDDHOLLC_00075	0.0	malK	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MDDHOLLC_00076	5.63e-163	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
MDDHOLLC_00077	1.94e-247	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
MDDHOLLC_00078	0.0	yufO	3.6.3.17	-	S	ko:K02056	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_00079	3.86e-238	yufP	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MDDHOLLC_00080	4.39e-218	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MDDHOLLC_00082	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MDDHOLLC_00083	5.18e-89	mrpB	-	-	P	ko:K05566	-	ko00000,ko02000	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MDDHOLLC_00084	1.47e-67	mrpC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MDDHOLLC_00085	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MDDHOLLC_00086	9.67e-99	mrpE	-	-	P	ko:K05569	-	ko00000,ko02000	Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MDDHOLLC_00087	1.1e-51	mrpF	-	-	P	ko:K05570	-	ko00000,ko02000	Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MDDHOLLC_00088	4.2e-79	mrpG	-	-	P	ko:K05571	-	ko00000,ko02000	COG1320 Multisubunit Na H antiporter, MnhG subunit
MDDHOLLC_00089	2.71e-81	yuxO	-	-	Q	-	-	-	protein, possibly involved in aromatic compounds catabolism
MDDHOLLC_00090	8.07e-148	comA	-	-	K	ko:K07691	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_00091	0.0	comP	2.7.13.3	-	T	ko:K07680	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00093	6.38e-118	comQ	-	-	H	ko:K02251	ko02024,map02024	ko00000,ko00001,ko02044	Polyprenyl synthetase
MDDHOLLC_00094	2.66e-11	-	-	-	S	-	-	-	DegQ (SacQ) family
MDDHOLLC_00096	6.01e-67	yuzC	-	-	-	-	-	-	-
MDDHOLLC_00097	6.32e-294	yuxH	-	-	T	-	-	-	signal transduction protein containing EAL and modified HD-GYP domains
MDDHOLLC_00098	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MDDHOLLC_00099	8.02e-135	pncA	-	-	Q	ko:K16788	-	ko00000,ko02000	COG1335 Amidases related to nicotinamidase
MDDHOLLC_00100	7.94e-90	yueI	-	-	S	-	-	-	Protein of unknown function (DUF1694)
MDDHOLLC_00101	5.46e-51	yueH	-	-	S	-	-	-	YueH-like protein
MDDHOLLC_00102	9e-46	yueG	-	-	S	ko:K06299	-	ko00000	Spore germination protein gerPA/gerPF
MDDHOLLC_00103	2.6e-144	yueF	-	-	S	-	-	-	transporter activity
MDDHOLLC_00104	4.98e-51	yueF	-	-	S	-	-	-	transporter activity
MDDHOLLC_00105	1.98e-31	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
MDDHOLLC_00106	2.23e-124	yueE	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
MDDHOLLC_00107	5.85e-169	yueD	1.1.1.320	-	IQ	ko:K16216	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_00108	1.89e-100	yueC	-	-	S	-	-	-	Family of unknown function (DUF5383)
MDDHOLLC_00109	8.41e-271	yueB	-	-	S	-	-	-	type VII secretion protein EsaA
MDDHOLLC_00110	2.72e-306	yueB	-	-	S	-	-	-	type VII secretion protein EsaA
MDDHOLLC_00111	0.0	essC	-	-	D	ko:K03466	-	ko00000,ko03036	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
MDDHOLLC_00112	3.19e-219	essC	-	-	D	ko:K03466	-	ko00000,ko03036	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
MDDHOLLC_00113	4.2e-271	essB	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukC
MDDHOLLC_00114	9.1e-54	yukD	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukD
MDDHOLLC_00115	2.36e-61	yukE	-	-	S	-	-	-	Belongs to the WXG100 family
MDDHOLLC_00116	2.64e-278	yukF	-	-	QT	-	-	-	Transcriptional regulator
MDDHOLLC_00117	6.65e-260	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
MDDHOLLC_00118	1.7e-168	yukJ	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2278)
MDDHOLLC_00119	2.24e-45	mbtH	-	-	S	ko:K05375	ko00261,ko01130,map00261,map01130	ko00000,ko00001,ko00002	MbtH-like protein
MDDHOLLC_00120	0.0	dhbF	-	-	Q	ko:K04780	ko01053,map01053	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_00121	1.87e-218	dhbB	3.3.2.1, 6.3.2.14	-	Q	ko:K01252	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	Isochorismatase family
MDDHOLLC_00122	0.0	entE	2.7.7.58, 6.3.2.14	-	Q	ko:K02363,ko:K04783	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	2,3-dihydroxybenzoate-AMP ligase
MDDHOLLC_00123	5.44e-277	dhbC	5.4.4.2	-	HQ	ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
MDDHOLLC_00124	5.57e-168	dhbA	1.3.1.28	-	IQ	ko:K00216	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_00125	1.21e-209	eSD	-	-	S	ko:K07017	-	ko00000	Putative esterase
MDDHOLLC_00126	4.59e-155	yuiH	-	-	S	-	-	-	Oxidoreductase molybdopterin binding domain
MDDHOLLC_00127	3.73e-131	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Biotin biosynthesis protein
MDDHOLLC_00128	9.54e-275	yuiF	-	-	S	ko:K07084	-	ko00000,ko02000	antiporter
MDDHOLLC_00129	0.0	pepA	3.4.11.1	-	E	ko:K01255	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MDDHOLLC_00130	7.09e-101	yuiD	-	-	S	ko:K09775	-	ko00000	protein conserved in bacteria
MDDHOLLC_00131	4.02e-152	yuiC	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00132	8.54e-46	yuiB	-	-	S	-	-	-	Putative membrane protein
MDDHOLLC_00133	4.16e-301	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MDDHOLLC_00134	1.03e-238	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	reductase
MDDHOLLC_00136	1.29e-234	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MDDHOLLC_00137	5.68e-40	-	-	-	-	-	-	-	-
MDDHOLLC_00138	1.63e-90	-	-	-	CP	-	-	-	Membrane
MDDHOLLC_00139	1.08e-155	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
MDDHOLLC_00141	5.3e-44	-	-	-	S	-	-	-	Bacteriocin class IId cyclical uberolysin-like
MDDHOLLC_00143	1.67e-35	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MDDHOLLC_00144	7.1e-175	dltE	-	-	M	ko:K14189	-	ko00000,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_00145	1.38e-82	erpA	-	-	S	ko:K13628	-	ko00000,ko03016	Belongs to the HesB IscA family
MDDHOLLC_00146	2.63e-206	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MDDHOLLC_00147	1.96e-261	yutK	-	-	F	ko:K03317	-	ko00000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MDDHOLLC_00148	1.74e-52	yuzB	-	-	S	-	-	-	Belongs to the UPF0349 family
MDDHOLLC_00149	1.71e-265	yutJ	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MDDHOLLC_00150	5.46e-72	yuzD	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00151	1.26e-47	yutI	-	-	O	-	-	-	COG0694 Thioredoxin-like proteins and domains
MDDHOLLC_00152	0.0	yuxL	3.4.19.1	-	EU	ko:K01303	-	ko00000,ko01000,ko01002	peptidase
MDDHOLLC_00153	1.12e-215	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MDDHOLLC_00154	2.3e-251	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MDDHOLLC_00155	1.43e-308	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
MDDHOLLC_00156	4.25e-248	yutH	-	-	S	-	-	-	Spore coat protein
MDDHOLLC_00157	1.5e-109	yutG	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
MDDHOLLC_00158	1.18e-179	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MDDHOLLC_00159	3e-93	yutE	-	-	S	-	-	-	Protein of unknown function DUF86
MDDHOLLC_00160	3.71e-62	yutD	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00161	3.92e-215	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MDDHOLLC_00162	6.78e-250	lytH	-	-	M	ko:K21472	-	ko00000,ko01000,ko01002,ko01011	Peptidase, M23
MDDHOLLC_00163	1.49e-141	yunB	-	-	S	-	-	-	Sporulation protein YunB (Spo_YunB)
MDDHOLLC_00164	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
MDDHOLLC_00165	4.99e-185	yunE	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MDDHOLLC_00166	1.63e-158	yunF	-	-	S	-	-	-	Protein of unknown function DUF72
MDDHOLLC_00167	4.16e-78	-	-	-	S	-	-	-	phosphoglycolate phosphatase activity
MDDHOLLC_00168	0.0	allB	3.5.2.5	-	F	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
MDDHOLLC_00169	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
MDDHOLLC_00170	6.7e-06	yqbD	-	-	L	-	-	-	Putative phage serine protease XkdF
MDDHOLLC_00174	1.23e-273	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_00175	1.99e-300	pucG	2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51	-	E	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	ko00000,ko00001,ko00002,ko01000,ko01007	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
MDDHOLLC_00176	5.44e-296	pucF	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MDDHOLLC_00177	7.92e-215	bsn	-	-	L	-	-	-	Ribonuclease
MDDHOLLC_00178	1.3e-262	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_00179	2.4e-172	frlR1	-	-	K	ko:K03710,ko:K10711	-	ko00000,ko03000	UTRA
MDDHOLLC_00180	1.72e-128	-	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
MDDHOLLC_00181	4.78e-54	-	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
MDDHOLLC_00182	8.84e-210	-	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
MDDHOLLC_00183	1.51e-202	yurN	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MDDHOLLC_00184	4.57e-168	yurO	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1653 ABC-type sugar transport system, periplasmic component
MDDHOLLC_00185	2.48e-118	yurO	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1653 ABC-type sugar transport system, periplasmic component
MDDHOLLC_00186	1.35e-237	frlB	-	-	M	ko:K10708	-	ko00000,ko01000	Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
MDDHOLLC_00187	2.73e-211	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MDDHOLLC_00189	3.33e-85	yurQ	-	-	L	-	-	-	COG0322 Nuclease subunit of the excinuclease complex
MDDHOLLC_00190	4.82e-255	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
MDDHOLLC_00191	6.41e-32	yncE	-	-	S	-	-	-	Protein of unknown function (DUF2691)
MDDHOLLC_00192	3.07e-202	csn	3.2.1.132	-	M	ko:K01233	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
MDDHOLLC_00193	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	FeS cluster assembly
MDDHOLLC_00194	8.89e-101	nifU	-	-	C	ko:K04488	-	ko00000	COG0822 NifU homolog involved in Fe-S cluster formation
MDDHOLLC_00195	2.31e-298	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MDDHOLLC_00196	5.01e-311	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
MDDHOLLC_00197	3.82e-183	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
MDDHOLLC_00198	2.54e-84	yurZ	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MDDHOLLC_00199	9e-187	metQ	-	-	P	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
MDDHOLLC_00200	2.08e-138	metI	-	-	P	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
MDDHOLLC_00201	3.71e-237	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MDDHOLLC_00202	5.28e-76	yusD	-	-	S	-	-	-	SCP-2 sterol transfer family
MDDHOLLC_00203	1.64e-72	yusE	-	-	CO	-	-	-	Thioredoxin
MDDHOLLC_00204	2.17e-82	yusF	-	-	L	ko:K07476	-	ko00000	COG1658 Small primase-like proteins (Toprim domain)
MDDHOLLC_00205	3.1e-55	yusG	-	-	S	-	-	-	Protein of unknown function (DUF2553)
MDDHOLLC_00206	4.16e-85	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
MDDHOLLC_00207	7.13e-84	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
MDDHOLLC_00208	0.0	fadE	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
MDDHOLLC_00209	7.74e-278	fadA	2.3.1.16	-	I	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the thiolase family
MDDHOLLC_00210	0.0	fadN	1.1.1.35	-	I	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	ko00000,ko00001,ko00002,ko01000	3-hydroxyacyl-CoA dehydrogenase
MDDHOLLC_00211	1.71e-211	fadM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
MDDHOLLC_00212	6.46e-58	-	-	-	-	-	-	-	-
MDDHOLLC_00213	4.46e-72	yusN	-	-	M	-	-	-	Coat F domain
MDDHOLLC_00214	9.65e-92	yusO	-	-	K	-	-	-	Iron dependent repressor, N-terminal DNA binding domain
MDDHOLLC_00215	0.0	yusP	-	-	P	-	-	-	Major facilitator superfamily
MDDHOLLC_00216	5.44e-200	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00217	5.88e-176	-	4.1.1.4	-	Q	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	ko00000,ko00001,ko00002,ko01000	Acetoacetate decarboxylase (ADC)
MDDHOLLC_00218	1.83e-235	apbA	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MDDHOLLC_00219	2.15e-52	yusU	-	-	S	-	-	-	Protein of unknown function (DUF2573)
MDDHOLLC_00220	5.24e-192	yusV	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MDDHOLLC_00221	7.61e-60	-	-	-	S	-	-	-	YusW-like protein
MDDHOLLC_00222	0.0	pepF2	-	-	E	-	-	-	COG1164 Oligoendopeptidase F
MDDHOLLC_00223	3.96e-190	yusZ	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_00224	1.18e-102	dps2	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
MDDHOLLC_00225	2.65e-305	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MDDHOLLC_00226	3.17e-164	cssR	-	-	T	ko:K07770	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00227	0.0	cssS	2.7.13.3	-	T	ko:K07650	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00228	4.63e-33	-	-	-	-	-	-	-	-
MDDHOLLC_00229	7.31e-200	yuxN	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00230	2.75e-255	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MDDHOLLC_00231	6.64e-37	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MDDHOLLC_00232	1.83e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF3970)
MDDHOLLC_00233	0.0	gerAA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
MDDHOLLC_00234	2.79e-187	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
MDDHOLLC_00235	1.07e-262	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
MDDHOLLC_00236	8.35e-139	vraR	-	-	KT	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_00237	3.48e-247	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00238	2.77e-69	-	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
MDDHOLLC_00239	3.82e-78	-	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
MDDHOLLC_00240	5.11e-186	liaG	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
MDDHOLLC_00241	3.63e-129	liaH	-	-	KT	ko:K03969,ko:K11620	ko02020,map02020	ko00000,ko00001,ko00002	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
MDDHOLLC_00242	6.33e-66	liaI	-	-	S	ko:K11619	ko02020,map02020	ko00000,ko00001,ko00002	membrane
MDDHOLLC_00243	2.27e-288	yvqJ	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_00244	1.87e-132	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Adenosyltransferase
MDDHOLLC_00245	1.24e-278	yvrA	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
MDDHOLLC_00246	1.47e-226	btuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_00247	9.55e-215	yvrC	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MDDHOLLC_00248	8.63e-181	yvrD	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_00249	3.11e-218	yvrE	-	-	G	ko:K14274	ko00040,map00040	ko00000,ko00001,ko01000	SMP-30/Gluconolaconase/LRE-like region
MDDHOLLC_00250	2.11e-135	yvrG	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_00251	8.31e-249	yvrG	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_00252	1.56e-171	yvrH	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00253	1.67e-50	-	-	-	-	-	-	-	-
MDDHOLLC_00254	1.31e-133	yvrI	-	-	K	ko:K03093	-	ko00000,ko03021	RNA polymerase
MDDHOLLC_00255	1.88e-21	-	-	-	S	-	-	-	YvrJ protein family
MDDHOLLC_00256	7.32e-294	oxdC	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
MDDHOLLC_00257	2.8e-87	yvrL	-	-	S	-	-	-	Regulatory protein YrvL
MDDHOLLC_00258	9.77e-20	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MDDHOLLC_00259	2.35e-149	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MDDHOLLC_00260	4.58e-224	fhuG	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_00261	1.9e-237	fhuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_00262	2.21e-228	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MDDHOLLC_00263	3.07e-160	-	-	-	Q	-	-	-	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MDDHOLLC_00264	0.0	yvsH	-	-	E	ko:K03294,ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
MDDHOLLC_00265	4.34e-19	-	-	-	S	ko:K06427	-	ko00000	Small spore protein J (Spore_SspJ)
MDDHOLLC_00266	8.3e-110	yvsG	-	-	S	ko:K07038	-	ko00000	LexA-binding, inner membrane-associated putative hydrolase
MDDHOLLC_00267	0.0	yvgJ	-	-	M	ko:K01138	-	ko00000,ko01000	Belongs to the LTA synthase family
MDDHOLLC_00268	4.72e-212	yvgK	-	-	P	ko:K07219	-	ko00000	COG1910 Periplasmic molybdate-binding protein domain
MDDHOLLC_00269	1.13e-177	modA	-	-	P	ko:K02020	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0725 ABC-type molybdate transport system, periplasmic component
MDDHOLLC_00270	5.72e-127	modB	-	-	P	ko:K02018	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4149 ABC-type molybdate transport system, permease component
MDDHOLLC_00271	5.32e-147	yfiK	-	-	K	-	-	-	Regulator
MDDHOLLC_00272	4.77e-250	-	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_00273	8.23e-219	sagG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
MDDHOLLC_00274	1.36e-246	sagH	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MDDHOLLC_00275	1.49e-254	sagI	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
MDDHOLLC_00276	5.09e-200	yvgN	-	-	S	-	-	-	reductase
MDDHOLLC_00277	1.32e-111	yvgO	-	-	-	-	-	-	-
MDDHOLLC_00278	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	COG0025 NhaP-type Na H and K H antiporters
MDDHOLLC_00279	0.0	cysI	1.8.1.2, 1.8.7.1	-	P	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
MDDHOLLC_00280	0.0	cysJ	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MDDHOLLC_00281	8.13e-72	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_00282	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_00283	2.48e-127	yvgT	-	-	S	-	-	-	membrane
MDDHOLLC_00284	1.1e-189	-	-	-	S	-	-	-	Metallo-peptidase family M12
MDDHOLLC_00285	7.48e-96	bdbC	-	-	O	ko:K03611	-	ko00000,ko03110	Required for disulfide bond formation in some proteins
MDDHOLLC_00286	5.28e-137	bdbD	-	-	O	-	-	-	Thioredoxin
MDDHOLLC_00287	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
MDDHOLLC_00288	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
MDDHOLLC_00289	3.24e-40	-	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	Heavy-metal-associated domain
MDDHOLLC_00290	2.81e-64	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	transcriptional
MDDHOLLC_00291	7.9e-246	yvaA	1.1.1.371	-	S	ko:K16044	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
MDDHOLLC_00292	1.43e-153	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MDDHOLLC_00293	0.0	ytnJ	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_00294	1.01e-61	ytnI	-	-	O	-	-	-	COG0695 Glutaredoxin and related proteins
MDDHOLLC_00295	3.04e-233	ytmO	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_00296	3.01e-179	tcyN	-	-	E	ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MDDHOLLC_00297	2.36e-155	-	-	-	U	ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MDDHOLLC_00298	4.04e-154	ytmL	-	-	P	ko:K16958,ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MDDHOLLC_00299	8.33e-187	tcyK	-	-	M	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
MDDHOLLC_00300	1.14e-165	-	-	-	ET	ko:K16956,ko:K16957,ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
MDDHOLLC_00301	3.16e-130	ytmI	-	-	K	ko:K00680	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
MDDHOLLC_00302	3.98e-206	ytlI	-	-	K	ko:K21960	-	ko00000,ko03000	LysR substrate binding domain
MDDHOLLC_00303	3.94e-180	yvaG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_00304	1.63e-63	yrdF	-	-	K	ko:K03623	-	ko00000	ribonuclease inhibitor
MDDHOLLC_00306	4.85e-107	smpB	-	-	O	ko:K03664	-	ko00000	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MDDHOLLC_00307	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MDDHOLLC_00308	6.92e-183	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Carboxylesterase
MDDHOLLC_00309	4.58e-36	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
MDDHOLLC_00310	1.64e-47	yvzC	-	-	K	-	-	-	transcriptional
MDDHOLLC_00311	9.53e-93	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	transcriptional
MDDHOLLC_00312	3.52e-96	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	Cro/C1-type HTH DNA-binding domain
MDDHOLLC_00313	2.97e-70	yvaP	-	-	K	-	-	-	transcriptional
MDDHOLLC_00314	0.0	spaK	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
MDDHOLLC_00315	1.29e-156	spaR	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
MDDHOLLC_00316	5.18e-174	spaG	-	-	S	ko:K20492	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MDDHOLLC_00317	2.43e-157	spaE	-	-	S	ko:K20491	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MDDHOLLC_00318	2.67e-162	spaF	-	-	V	ko:K01990,ko:K20459,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_00319	2.09e-144	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MDDHOLLC_00320	7.34e-219	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MDDHOLLC_00321	3.4e-146	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MDDHOLLC_00322	1.77e-262	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MDDHOLLC_00323	3.42e-124	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
MDDHOLLC_00324	3.59e-140	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MDDHOLLC_00325	5.39e-221	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MDDHOLLC_00326	1.61e-144	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MDDHOLLC_00327	2.45e-268	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MDDHOLLC_00328	2.38e-128	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
MDDHOLLC_00329	4.44e-134	yvbG	-	-	U	ko:K05595	-	ko00000,ko02000	UPF0056 membrane protein
MDDHOLLC_00330	3.1e-156	yvbI	-	-	M	-	-	-	Membrane
MDDHOLLC_00331	0.0	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
MDDHOLLC_00332	1.29e-105	yvbK	-	-	K	-	-	-	acetyltransferase
MDDHOLLC_00333	2.99e-267	-	-	-	EGP	-	-	-	Major facilitator Superfamily
MDDHOLLC_00334	3.14e-225	-	-	-	-	-	-	-	-
MDDHOLLC_00335	8.69e-160	-	-	-	S	-	-	-	GlcNAc-PI de-N-acetylase
MDDHOLLC_00336	4.79e-184	-	-	-	C	-	-	-	WbqC-like protein family
MDDHOLLC_00337	1.64e-184	-	-	-	M	-	-	-	Protein involved in cellulose biosynthesis
MDDHOLLC_00338	3.75e-285	-	-	-	E	-	-	-	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MDDHOLLC_00339	2.36e-217	arnA	4.2.1.46, 5.1.3.2	-	M	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	ko00000,ko00001,ko00002,ko01000	GDP-mannose 4,6 dehydratase
MDDHOLLC_00340	1.89e-275	-	2.6.1.102	-	E	ko:K13010	ko00520,map00520	ko00000,ko00001,ko01000,ko01005,ko01007	Belongs to the DegT DnrJ EryC1 family
MDDHOLLC_00341	0.0	-	1.1.1.136	-	M	ko:K13015	ko00520,map00520	ko00000,ko00001,ko01000,ko01005	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MDDHOLLC_00342	1.63e-301	ywaD	3.4.11.10, 3.4.11.6	-	S	ko:K19701	-	ko00000,ko01000,ko01002	PA domain
MDDHOLLC_00343	9.69e-310	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MDDHOLLC_00344	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of 2-phosphoglycerate and
MDDHOLLC_00345	2.58e-177	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MDDHOLLC_00346	3.98e-277	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
MDDHOLLC_00347	2.83e-238	gapA	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MDDHOLLC_00348	2.95e-240	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MDDHOLLC_00350	2.53e-280	araE	-	-	U	ko:K02100,ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MDDHOLLC_00351	1.11e-260	araR	-	-	K	ko:K02103	-	ko00000,ko03000	transcriptional
MDDHOLLC_00352	2.53e-241	yvbT	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_00354	1.51e-200	yvbU	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00355	1.75e-201	yvbV	-	-	EG	-	-	-	EamA-like transporter family
MDDHOLLC_00356	9.5e-275	yvbW	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_00358	3.6e-189	gntR	-	-	K	-	-	-	RpiR family transcriptional regulator
MDDHOLLC_00359	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
MDDHOLLC_00360	1.6e-289	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
MDDHOLLC_00361	9.73e-171	lutC	-	-	S	ko:K00782	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MDDHOLLC_00362	0.0	lutB	-	-	C	ko:K18929	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
MDDHOLLC_00363	2.14e-173	lutA	-	-	C	ko:K18928	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MDDHOLLC_00364	1.33e-276	-	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MDDHOLLC_00365	3.62e-155	yvfI	-	-	K	ko:K05799	-	ko00000,ko03000	COG2186 Transcriptional regulators
MDDHOLLC_00366	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
MDDHOLLC_00367	1.32e-308	rpoN	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
MDDHOLLC_00368	4.01e-44	yvfG	-	-	S	-	-	-	YvfG protein
MDDHOLLC_00369	3.71e-236	epsO	-	-	GM	ko:K19431	-	ko00000,ko01000	Exopolysaccharide biosynthesis protein
MDDHOLLC_00370	2.14e-279	epsN	-	-	E	ko:K19430	-	ko00000,ko01000	Belongs to the DegT DnrJ EryC1 family
MDDHOLLC_00371	2.23e-71	epsM	-	-	GM	ko:K19429	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
MDDHOLLC_00372	1.11e-139	epsL	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MDDHOLLC_00373	0.0	epsK	-	-	S	ko:K19418	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_00374	3.5e-248	epsJ	-	GT2	S	ko:K19427	-	ko00000,ko01000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_00375	1.29e-257	epsI	-	-	GM	ko:K19426	-	ko00000,ko01000	pyruvyl transferase
MDDHOLLC_00376	1.04e-245	epsH	-	GT2	S	ko:K19425	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
MDDHOLLC_00377	6.95e-262	epsG	-	-	S	ko:K19419	-	ko00000,ko02000	EpsG family
MDDHOLLC_00378	9.63e-270	epsF	-	GT4	M	ko:K19424	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
MDDHOLLC_00379	1.85e-204	epsE	-	GT2	M	ko:K19423	-	ko00000,ko01000,ko01003	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_00380	3.53e-277	epsD	-	GT4	M	ko:K19422	-	ko00000,ko01000	Glycosyl transferase 4-like
MDDHOLLC_00381	0.0	capD	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MDDHOLLC_00382	3.12e-151	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
MDDHOLLC_00383	7.89e-154	epsA	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
MDDHOLLC_00384	6.96e-100	-	-	-	K	ko:K19417	-	ko00000,ko03000	transcriptional
MDDHOLLC_00385	0.0	pnbA	-	CE10	I	ko:K03929	-	ko00000,ko01000	Belongs to the type-B carboxylesterase lipase family
MDDHOLLC_00386	5.78e-62	ywjB	-	-	H	-	-	-	RibD C-terminal domain
MDDHOLLC_00387	3.17e-31	ywjB	-	-	H	-	-	-	RibD C-terminal domain
MDDHOLLC_00388	4.34e-145	yyaS	-	-	S	ko:K07149	-	ko00000	Membrane
MDDHOLLC_00389	4.23e-26	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_00390	4.44e-61	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_00391	1.01e-120	padC	-	-	Q	ko:K13727	-	ko00000,ko01000	Phenolic acid decarboxylase
MDDHOLLC_00392	4.22e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF1433)
MDDHOLLC_00394	3.1e-230	-	-	-	I	-	-	-	Pfam Lipase (class 3)
MDDHOLLC_00395	8.04e-39	-	-	-	I	-	-	-	Pfam Lipase (class 3)
MDDHOLLC_00396	1.08e-44	-	-	-	-	-	-	-	-
MDDHOLLC_00398	0.0	cscA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
MDDHOLLC_00399	4.72e-284	rafB	-	-	P	ko:K02532	-	ko00000,ko02000	LacY proton/sugar symporter
MDDHOLLC_00400	3.6e-113	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
MDDHOLLC_00401	3.26e-80	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
MDDHOLLC_00402	3.74e-136	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MDDHOLLC_00403	3.34e-210	yraN	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00404	2.75e-268	yraM	-	-	S	-	-	-	PrpF protein
MDDHOLLC_00405	5.06e-289	-	-	-	EGP	-	-	-	Sugar (and other) transporter
MDDHOLLC_00407	1.54e-136	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
MDDHOLLC_00408	1.3e-69	yvdC	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
MDDHOLLC_00409	0.0	yvdB	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
MDDHOLLC_00410	4.41e-137	yvdA	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
MDDHOLLC_00411	1.69e-232	yvcT	1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81	-	CH	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MDDHOLLC_00412	8.99e-104	-	-	-	M	-	-	-	Ribonuclease
MDDHOLLC_00413	1.99e-183	yvcN	2.3.1.118	-	Q	ko:K00675	-	ko00000,ko01000	Belongs to the arylamine N-acetyltransferase family
MDDHOLLC_00414	3.23e-49	crh	-	-	G	ko:K11184	-	ko00000	Phosphocarrier protein Chr
MDDHOLLC_00415	5.16e-220	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
MDDHOLLC_00416	8.99e-226	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
MDDHOLLC_00417	2.09e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
MDDHOLLC_00418	5.15e-113	yvcI	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MDDHOLLC_00419	3.13e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MDDHOLLC_00420	3.05e-203	spl	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	protein conserved in bacteria
MDDHOLLC_00421	0.0	yvcD	-	-	S	-	-	-	COG0457 FOG TPR repeat
MDDHOLLC_00422	6.47e-244	sasA	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_00423	1.33e-156	mprA3	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00424	5.64e-63	-	-	-	-	-	-	-	-
MDDHOLLC_00425	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
MDDHOLLC_00426	4.7e-143	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the PRA-CH family
MDDHOLLC_00427	1.09e-173	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MDDHOLLC_00428	1.32e-166	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MDDHOLLC_00429	8.08e-147	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MDDHOLLC_00430	3.35e-137	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
MDDHOLLC_00431	1.51e-296	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MDDHOLLC_00432	7.47e-148	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MDDHOLLC_00433	2.45e-269	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MDDHOLLC_00434	8.4e-177	yvpB	-	-	NU	-	-	-	protein conserved in bacteria
MDDHOLLC_00435	2.42e-110	yvoF	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
MDDHOLLC_00436	4.51e-155	ppaX	3.6.1.1	-	S	ko:K06019	ko00190,map00190	ko00000,ko00001,ko01000	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
MDDHOLLC_00437	2.4e-191	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MDDHOLLC_00438	3.62e-217	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MDDHOLLC_00439	2.25e-284	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MDDHOLLC_00440	2.22e-172	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MDDHOLLC_00441	4.29e-171	yvoA	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
MDDHOLLC_00442	1.73e-133	yxaF	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
MDDHOLLC_00443	0.0	yvnB	-	-	Q	-	-	-	Calcineurin-like phosphoesterase
MDDHOLLC_00444	3.12e-65	yvlD	-	-	S	ko:K08972	-	ko00000	Membrane
MDDHOLLC_00445	8.1e-36	yvlC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain
MDDHOLLC_00446	9.16e-218	yvlB	-	-	S	-	-	-	Putative adhesin
MDDHOLLC_00447	4.87e-66	yvlA	-	-	-	-	-	-	-
MDDHOLLC_00448	6.81e-47	yvkN	-	-	-	-	-	-	-
MDDHOLLC_00449	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MDDHOLLC_00450	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MDDHOLLC_00451	2.59e-45	csbA	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00452	0.0	yvkC	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphotransferase
MDDHOLLC_00453	1.91e-143	yvkB	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00454	8.04e-296	yvkA	-	-	P	-	-	-	-transporter
MDDHOLLC_00456	3.57e-281	minJ	-	-	O	-	-	-	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MDDHOLLC_00457	2.47e-73	swrA	-	-	S	-	-	-	Swarming motility protein
MDDHOLLC_00458	0.0	ctpB	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
MDDHOLLC_00459	1.64e-302	ywoF	-	-	P	-	-	-	Right handed beta helix region
MDDHOLLC_00460	2.89e-197	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
MDDHOLLC_00461	3.53e-158	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
MDDHOLLC_00462	3.08e-60	cccB	-	-	C	ko:K12263,ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
MDDHOLLC_00463	2.36e-62	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_00464	1.26e-78	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_00465	6.64e-233	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MDDHOLLC_00466	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MDDHOLLC_00467	1.41e-100	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MDDHOLLC_00468	3.94e-133	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MDDHOLLC_00469	1.35e-89	-	-	-	-	-	-	-	-
MDDHOLLC_00470	2.77e-11	fliT	-	-	N	ko:K02423	ko02040,map02040	ko00000,ko00001,ko02035	bacterial-type flagellum organization
MDDHOLLC_00471	5.79e-88	fliS	-	-	N	ko:K02422	ko02040,map02040	ko00000,ko00001,ko02035	flagellar protein FliS
MDDHOLLC_00472	0.0	fliD	-	-	N	ko:K02407	ko02040,map02040	ko00000,ko00001,ko02035	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MDDHOLLC_00473	9.98e-154	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MDDHOLLC_00474	2.67e-43	csrA	-	-	T	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	ko00000,ko00001,ko03019	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MDDHOLLC_00475	1.01e-95	fliW	-	-	S	ko:K13626	-	ko00000,ko02035	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MDDHOLLC_00476	3.27e-107	yviE	-	-	-	-	-	-	-
MDDHOLLC_00477	3.29e-206	flgL	-	-	N	ko:K02397	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the bacterial flagellin family
MDDHOLLC_00478	0.0	flgK	-	-	N	ko:K02396	ko02040,map02040	ko00000,ko00001,ko02035	flagellar hook-associated protein
MDDHOLLC_00479	2.2e-105	yvyG	-	-	NOU	-	-	-	FlgN protein
MDDHOLLC_00480	6.14e-53	flgM	-	-	KNU	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	ko00000,ko00001,ko02035	Negative regulator of flagellin synthesis
MDDHOLLC_00481	2.23e-97	yvyF	-	-	S	-	-	-	flagellar protein
MDDHOLLC_00482	6.79e-98	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Phosphoribosyl transferase domain
MDDHOLLC_00483	3.56e-57	comFB	-	-	S	ko:K02241	-	ko00000,ko00002,ko02044	Late competence development protein ComFB
MDDHOLLC_00484	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MDDHOLLC_00485	3.59e-203	degV	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00486	7.16e-163	degU	-	-	KT	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_00487	1.4e-246	degS	2.7.13.3	-	T	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
MDDHOLLC_00488	1.02e-111	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
MDDHOLLC_00489	6.94e-32	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
MDDHOLLC_00490	2.21e-229	yvhJ	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00491	3.12e-233	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
MDDHOLLC_00492	2.49e-298	tuaH	-	-	M	ko:K16699	-	ko00000,ko01000,ko01003	Teichuronic acid biosynthesis glycosyltransferase tuaH
MDDHOLLC_00493	2.82e-185	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
MDDHOLLC_00494	5.79e-147	tuaF	-	-	M	ko:K16706	-	ko00000	protein involved in exopolysaccharide biosynthesis
MDDHOLLC_00495	0.0	tuaE	-	-	M	ko:K16705	-	ko00000	Teichuronic acid biosynthesis protein
MDDHOLLC_00496	1.57e-314	tuaD	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MDDHOLLC_00497	7.54e-284	tuaC	-	GT4	GM	ko:K16697	-	ko00000,ko01000,ko01003	Teichuronic acid
MDDHOLLC_00498	0.0	tuaB	-	-	S	ko:K03328,ko:K16694,ko:K16695	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_00499	4.69e-151	tuaA	-	-	M	-	-	-	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MDDHOLLC_00500	0.0	lytC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MDDHOLLC_00501	0.0	lytB	-	-	D	-	-	-	Stage II sporulation protein
MDDHOLLC_00502	1.86e-64	-	-	-	-	-	-	-	-
MDDHOLLC_00503	1.28e-203	lytR	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
MDDHOLLC_00504	1.93e-265	mnaA	5.1.3.14	-	M	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MDDHOLLC_00505	2.64e-211	gtaB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
MDDHOLLC_00506	0.0	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
MDDHOLLC_00507	5.06e-195	tagG	-	-	GM	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
MDDHOLLC_00508	0.0	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MDDHOLLC_00509	3.6e-118	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MDDHOLLC_00510	0.0	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MDDHOLLC_00511	1.06e-50	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase
MDDHOLLC_00512	8.69e-182	tagA	2.4.1.187	GT26	M	ko:K05946	ko05111,map05111	ko00000,ko00001,ko01000,ko01003	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
MDDHOLLC_00513	5.87e-276	tagB	2.7.8.44	-	M	ko:K21285	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MDDHOLLC_00514	0.0	lytD	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MDDHOLLC_00515	1.4e-233	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MDDHOLLC_00516	0.0	gerBA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
MDDHOLLC_00517	4.98e-251	gerBB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
MDDHOLLC_00518	1.3e-111	gerBC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination protein
MDDHOLLC_00519	1.16e-118	gerBC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination protein
MDDHOLLC_00520	8.46e-70	-	-	-	J	ko:K07011	-	ko00000	Glycosyl transferase family 2
MDDHOLLC_00521	1.42e-231	-	-	-	J	ko:K07011	-	ko00000	Glycosyl transferase family 2
MDDHOLLC_00522	8.17e-316	ywtG	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MDDHOLLC_00523	2.3e-229	ywtF_2	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00524	1.77e-200	ywtE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
MDDHOLLC_00525	2.96e-75	yttA	-	-	S	-	-	-	Pfam Transposase IS66
MDDHOLLC_00526	4.85e-298	pgdS	-	-	M	-	-	-	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MDDHOLLC_00527	4.04e-29	ywtC	-	-	-	-	-	-	-
MDDHOLLC_00528	2.7e-278	capA	-	-	M	ko:K07282	-	ko00000	enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
MDDHOLLC_00529	2.95e-91	capC	-	-	S	ko:K22116	-	ko00000	biosynthesis protein
MDDHOLLC_00530	1.46e-283	capB	-	-	M	ko:K01932	-	ko00000,ko01000	COG0769 UDP-N-acetylmuramyl tripeptide synthase
MDDHOLLC_00531	8.08e-245	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
MDDHOLLC_00532	8.49e-245	-	-	-	E	-	-	-	Spore germination protein
MDDHOLLC_00533	5.9e-259	gerKC	-	-	S	-	-	-	Spore germination B3/ GerAC like, C-terminal
MDDHOLLC_00534	6.07e-228	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
MDDHOLLC_00535	1.34e-199	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MDDHOLLC_00536	1.32e-83	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
MDDHOLLC_00537	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MDDHOLLC_00538	5.37e-205	rbsC	-	-	G	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MDDHOLLC_00539	1.15e-206	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	COG1879 ABC-type sugar transport system, periplasmic component
MDDHOLLC_00540	2.32e-71	batE	-	-	T	-	-	-	Sh3 type 3 domain protein
MDDHOLLC_00541	7.13e-123	ywrO	-	-	S	-	-	-	NADPH-quinone reductase (modulator of drug activity B)
MDDHOLLC_00542	5.71e-191	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
MDDHOLLC_00543	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
MDDHOLLC_00544	2.18e-214	alsR	-	-	K	-	-	-	LysR substrate binding domain
MDDHOLLC_00546	4.73e-301	ywrK	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MDDHOLLC_00547	4.87e-163	ywrJ	-	-	-	-	-	-	-
MDDHOLLC_00548	6.63e-172	cotB	-	-	-	ko:K06325	-	ko00000	-
MDDHOLLC_00549	2.65e-269	cotH	-	-	M	ko:K06330	-	ko00000	Spore Coat
MDDHOLLC_00550	8.43e-23	-	-	-	-	-	-	-	-
MDDHOLLC_00551	5.72e-144	ywrF	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MDDHOLLC_00553	0.0	ywrD	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
MDDHOLLC_00554	1.01e-109	ywrC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
MDDHOLLC_00555	6.69e-129	ywrB	-	-	P	ko:K07240	-	ko00000,ko02000	Chromate transporter
MDDHOLLC_00556	4.1e-112	ywrA	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
MDDHOLLC_00558	1.23e-119	ywqN	-	-	S	-	-	-	NAD(P)H-dependent
MDDHOLLC_00559	4.66e-200	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00561	1.39e-135	ywqJ	-	-	S	-	-	-	Pre-toxin TG
MDDHOLLC_00562	2.25e-54	-	-	-	S	-	-	-	Protein of unknown function (DUF2004)
MDDHOLLC_00563	2.92e-66	-	-	-	-	-	-	-	-
MDDHOLLC_00564	0.0	ywqJ	-	-	S	-	-	-	Pre-toxin TG
MDDHOLLC_00565	2.09e-50	ywqI	-	-	S	-	-	-	Family of unknown function (DUF5344)
MDDHOLLC_00567	7.76e-188	ywqG	-	-	S	-	-	-	Domain of unknown function (DUF1963)
MDDHOLLC_00568	8.35e-312	ywqF	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MDDHOLLC_00569	2.05e-179	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	COG4464 Capsular polysaccharide biosynthesis protein
MDDHOLLC_00570	4.45e-157	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
MDDHOLLC_00571	3.37e-150	ywqC	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
MDDHOLLC_00572	1.74e-21	-	-	-	-	-	-	-	-
MDDHOLLC_00573	0.0	ywqB	-	-	S	-	-	-	SWIM zinc finger
MDDHOLLC_00574	0.0	ywqA	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
MDDHOLLC_00575	7.2e-200	ywpJ	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
MDDHOLLC_00576	1.18e-181	glcR	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
MDDHOLLC_00577	1.47e-76	ssbB	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-stranded DNA-binding protein
MDDHOLLC_00578	4.49e-82	ywpG	-	-	-	-	-	-	-
MDDHOLLC_00579	1.07e-89	ywpF	-	-	S	-	-	-	YwpF-like protein
MDDHOLLC_00580	1.87e-74	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MDDHOLLC_00581	3.15e-98	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MDDHOLLC_00582	1.75e-253	rapD	-	-	S	ko:K06362	-	ko00000,ko01000	aspartate phosphatase
MDDHOLLC_00583	1.74e-183	flhP	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
MDDHOLLC_00584	2.09e-173	flhO	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
MDDHOLLC_00585	1.75e-231	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein
MDDHOLLC_00586	5.93e-60	spoIIID	-	-	K	ko:K06283	-	ko00000,ko03000	Stage III sporulation protein D
MDDHOLLC_00587	7.23e-93	ywoH	-	-	K	-	-	-	transcriptional
MDDHOLLC_00588	4.78e-271	ywoG	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_00589	0.0	-	-	-	FH	ko:K03457,ko:K10975	-	ko00000,ko02000	COG1953 Cytosine uracil thiamine allantoin permeases
MDDHOLLC_00590	2.31e-311	ywoD	-	-	EGP	-	-	-	Major facilitator superfamily
MDDHOLLC_00591	1.13e-132	yjgF	-	-	Q	-	-	-	Isochorismatase family
MDDHOLLC_00592	1.32e-291	nrgA	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium transporter
MDDHOLLC_00593	1.29e-76	nrgB	-	-	K	ko:K04751	ko02020,map02020	ko00000,ko00001	Belongs to the P(II) protein family
MDDHOLLC_00594	9.52e-264	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MDDHOLLC_00595	1.17e-131	bcrC	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	COG0671 Membrane-associated phospholipid phosphatase
MDDHOLLC_00596	5.45e-94	ywnJ	-	-	S	-	-	-	VanZ like family
MDDHOLLC_00597	2.53e-186	spoIIQ	-	-	M	ko:K06386	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
MDDHOLLC_00598	2.76e-115	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	COG1247 Sortase and related acyltransferases
MDDHOLLC_00600	5.15e-90	ywnF	-	-	S	-	-	-	Family of unknown function (DUF5392)
MDDHOLLC_00601	0.0	ywnE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MDDHOLLC_00602	1.1e-76	ywnC	-	-	S	-	-	-	Family of unknown function (DUF5362)
MDDHOLLC_00603	1.52e-156	xlnB	3.2.1.8	-	G	ko:K01181	-	ko00000,ko01000	Glycosyl hydrolases family 11
MDDHOLLC_00604	3.09e-88	ywnA	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00605	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
MDDHOLLC_00606	1.07e-81	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease beta subunit family
MDDHOLLC_00607	1.94e-66	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease gamma subunit family
MDDHOLLC_00608	7.2e-18	csbD	-	-	K	-	-	-	CsbD-like
MDDHOLLC_00609	5e-106	ywmF	-	-	S	-	-	-	Peptidase M50
MDDHOLLC_00610	6.28e-116	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
MDDHOLLC_00611	1.53e-245	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MDDHOLLC_00612	4.3e-185	fdhD	-	-	C	ko:K02379	-	ko00000	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MDDHOLLC_00614	1.75e-157	ywmD	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MDDHOLLC_00615	1.36e-146	ywmC	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MDDHOLLC_00616	1.65e-241	spoIID	-	-	D	ko:K06381	-	ko00000	Stage II sporulation protein D
MDDHOLLC_00617	4.75e-304	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDDHOLLC_00618	4.83e-174	ywmB	-	-	S	-	-	-	TATA-box binding
MDDHOLLC_00619	1.3e-44	ywzB	-	-	S	-	-	-	membrane
MDDHOLLC_00620	6.9e-116	ywmA	-	-	-	-	-	-	-
MDDHOLLC_00621	8.24e-83	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
MDDHOLLC_00622	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MDDHOLLC_00623	4.46e-195	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MDDHOLLC_00624	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MDDHOLLC_00625	1.95e-116	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MDDHOLLC_00626	1.66e-82	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MDDHOLLC_00627	3.01e-36	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MDDHOLLC_00628	5.19e-168	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
MDDHOLLC_00629	4.49e-80	atpI	-	-	S	ko:K02116	-	ko00000,ko00194	ATP synthase
MDDHOLLC_00630	9.12e-147	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MDDHOLLC_00631	5.69e-299	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MDDHOLLC_00632	7.42e-125	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
MDDHOLLC_00633	6.74e-106	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase
MDDHOLLC_00634	1.2e-100	ywlE	3.1.3.48, 3.9.1.2	-	T	ko:K01104,ko:K20201	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MDDHOLLC_00635	5.09e-82	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MDDHOLLC_00636	9.56e-16	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MDDHOLLC_00637	3.08e-243	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MDDHOLLC_00638	1.08e-34	ywlB	-	-	E	-	-	-	Belongs to the acetyltransferase family. ArgA subfamily
MDDHOLLC_00639	4.84e-53	ywlB	-	-	E	-	-	-	Belongs to the acetyltransferase family. ArgA subfamily
MDDHOLLC_00640	1.88e-152	spoIIR	-	-	S	ko:K06387	-	ko00000	stage II sporulation protein R
MDDHOLLC_00641	2.08e-79	ywlA	-	-	S	-	-	-	Uncharacterised protein family (UPF0715)
MDDHOLLC_00643	1.29e-198	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MDDHOLLC_00644	1.11e-244	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MDDHOLLC_00645	9.07e-89	ywkD	-	-	E	ko:K08234	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_00646	4.94e-122	racA	-	-	K	ko:K11686	-	ko00000,ko03036	Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
MDDHOLLC_00647	1.93e-200	ywkB	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
MDDHOLLC_00648	0.0	ykwA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
MDDHOLLC_00649	4.76e-133	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
MDDHOLLC_00650	7e-45	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the 23S rRNA
MDDHOLLC_00651	1.53e-266	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MDDHOLLC_00652	1.43e-224	glpX	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	fructose-1,6-bisphosphatase
MDDHOLLC_00653	3.21e-303	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDDHOLLC_00654	6.37e-144	tal	2.2.1.2	-	G	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MDDHOLLC_00655	5.51e-204	fbaA	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Aldolase
MDDHOLLC_00656	1.07e-81	spo0F	-	-	T	ko:K02490	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG0784 FOG CheY-like receiver
MDDHOLLC_00657	6.41e-118	ywjG	-	-	S	-	-	-	Domain of unknown function (DUF2529)
MDDHOLLC_00658	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MDDHOLLC_00659	2.79e-74	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MDDHOLLC_00660	0.0	ywjF	-	-	C	-	-	-	COG0247 Fe-S oxidoreductase
MDDHOLLC_00661	2.84e-284	clsB	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the phospholipase D family. Cardiolipin synthase subfamily
MDDHOLLC_00662	1.29e-231	uvsE	-	-	L	ko:K13281	-	ko00000,ko01000	Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
MDDHOLLC_00663	1.13e-58	ywjC	-	-	-	-	-	-	-
MDDHOLLC_00664	0.0	ywjA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MDDHOLLC_00665	0.0	ywiE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MDDHOLLC_00666	2.89e-134	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MDDHOLLC_00667	3.83e-155	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase (gamma
MDDHOLLC_00668	8.57e-122	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	nitrate reductase
MDDHOLLC_00669	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase, beta
MDDHOLLC_00670	0.0	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MDDHOLLC_00671	2.44e-101	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MDDHOLLC_00672	1.68e-108	arfM	-	-	T	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	cyclic nucleotide binding
MDDHOLLC_00673	1.02e-176	ywiC	-	-	S	-	-	-	YwiC-like protein
MDDHOLLC_00674	7.4e-165	fnr	-	-	K	-	-	-	helix_turn_helix, cAMP Regulatory protein
MDDHOLLC_00675	2.03e-271	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
MDDHOLLC_00676	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
MDDHOLLC_00677	4.79e-57	ywiB	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00678	1.27e-101	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MDDHOLLC_00680	7.54e-40	ydcG	-	-	K	ko:K07729	-	ko00000,ko03000	sequence-specific DNA binding
MDDHOLLC_00681	9.48e-43	-	-	-	-	-	-	-	-
MDDHOLLC_00683	4.68e-98	-	-	-	CP	-	-	-	Membrane
MDDHOLLC_00686	4.95e-214	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
MDDHOLLC_00687	1.58e-203	speE	2.5.1.16	-	E	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MDDHOLLC_00688	0.0	pbpG	2.4.1.129, 3.4.16.4	GT51	M	ko:K21464	ko00550,map00550	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MDDHOLLC_00689	2.9e-104	-	-	-	-	-	-	-	-
MDDHOLLC_00690	2.73e-123	ywhD	-	-	S	-	-	-	YwhD family
MDDHOLLC_00691	3.84e-153	ywhC	-	-	S	-	-	-	Peptidase family M50
MDDHOLLC_00692	2.37e-34	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	4-oxalocrotonate tautomerase
MDDHOLLC_00693	9.43e-90	ywhA	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00694	1.02e-92	potE5	-	-	E	ko:K03294	-	ko00000	C-terminus of AA_permease
MDDHOLLC_00695	4.92e-184	potE5	-	-	E	ko:K03294	-	ko00000	C-terminus of AA_permease
MDDHOLLC_00696	8.24e-115	ywgA	-	-	-	ko:K09388	-	ko00000	-
MDDHOLLC_00697	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	COG1078 HD superfamily phosphohydrolases
MDDHOLLC_00698	8.55e-49	ywzC	-	-	S	-	-	-	Belongs to the UPF0741 family
MDDHOLLC_00699	3.37e-122	rsfA_1	-	-	-	ko:K06314	-	ko00000,ko03000	-
MDDHOLLC_00700	9.26e-69	-	-	-	K	ko:K10947	-	ko00000,ko03000	PadR family transcriptional regulator
MDDHOLLC_00701	7.62e-120	-	-	-	S	-	-	-	membrane
MDDHOLLC_00702	2.15e-207	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_00703	1.4e-213	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter (permease)
MDDHOLLC_00706	5.3e-225	-	-	-	-	-	-	-	-
MDDHOLLC_00708	2.41e-199	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
MDDHOLLC_00709	3.89e-211	cysL	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_00710	3.98e-212	-	-	-	S	-	-	-	Conserved hypothetical protein 698
MDDHOLLC_00711	2.03e-225	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	In Salmonella this enzyme is required for ethanolamine catabolism
MDDHOLLC_00712	4.87e-187	ywfI	-	-	C	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko01000	May function as heme-dependent peroxidase
MDDHOLLC_00713	9.82e-180	ywfH	-	-	IQ	ko:K19550	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Enoyl-(Acyl carrier protein) reductase
MDDHOLLC_00714	4.46e-297	ywfG	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
MDDHOLLC_00715	9.5e-264	bacE	-	-	EGP	ko:K19552	-	ko00000,ko02000	Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic
MDDHOLLC_00716	0.0	bacD	6.3.2.49	-	F	ko:K13037	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
MDDHOLLC_00717	1.56e-178	bacC	1.1.1.385	-	IQ	ko:K19548	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_00718	1.19e-176	bacB	5.3.3.19	-	S	ko:K19547	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
MDDHOLLC_00719	1.4e-146	bacA	4.1.1.100	-	E	ko:K19546	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
MDDHOLLC_00720	7.84e-284	ywfA	-	-	EGP	-	-	-	-transporter
MDDHOLLC_00721	1.34e-262	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
MDDHOLLC_00722	0.0	rocC	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MDDHOLLC_00723	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
MDDHOLLC_00724	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
MDDHOLLC_00725	3.15e-314	rocG	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MDDHOLLC_00726	6.37e-77	-	-	-	-	-	-	-	-
MDDHOLLC_00727	1.05e-41	spsL	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Spore Coat
MDDHOLLC_00728	3.89e-207	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MDDHOLLC_00729	1.51e-232	spsJ	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MDDHOLLC_00730	5.67e-177	spsI	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MDDHOLLC_00731	1.51e-131	spsG	-	-	M	-	-	-	Spore Coat
MDDHOLLC_00732	2.34e-56	spsG	-	-	M	-	-	-	Spore Coat
MDDHOLLC_00733	1.68e-170	spsF	-	-	M	ko:K07257	-	ko00000	Spore Coat
MDDHOLLC_00734	1.43e-273	pseI	2.5.1.56, 2.5.1.97	-	M	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	acid synthase
MDDHOLLC_00735	2.93e-200	spsD	2.3.1.210	-	K	ko:K16704	-	ko00000,ko01000	Spore Coat
MDDHOLLC_00736	4.86e-280	spsC	2.6.1.102	-	E	ko:K13010	ko00520,map00520	ko00000,ko00001,ko01000,ko01005,ko01007	Belongs to the DegT DnrJ EryC1 family
MDDHOLLC_00737	0.0	spsB	-	-	M	-	-	-	Capsule polysaccharide biosynthesis protein
MDDHOLLC_00738	5.24e-183	spsA	-	-	M	-	-	-	Spore Coat
MDDHOLLC_00739	6.62e-83	gerQ	-	-	S	ko:K06305	-	ko00000	Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
MDDHOLLC_00740	2.17e-76	ywdK	-	-	S	-	-	-	small membrane protein
MDDHOLLC_00741	2.6e-23	ywdJ	-	-	F	-	-	-	Xanthine uracil
MDDHOLLC_00742	1.2e-252	ywdJ	-	-	F	-	-	-	Xanthine uracil
MDDHOLLC_00743	1.57e-62	ywdI	-	-	S	-	-	-	Family of unknown function (DUF5327)
MDDHOLLC_00744	7.22e-171	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MDDHOLLC_00745	4.93e-120	ywdF	-	-	S	-	-	-	Glycosyltransferase like family 2
MDDHOLLC_00746	1.22e-41	ywdF	-	-	S	-	-	-	Glycosyltransferase like family 2
MDDHOLLC_00748	2.34e-114	ywdD	-	-	-	-	-	-	-
MDDHOLLC_00749	1.6e-75	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
MDDHOLLC_00750	4.13e-187	pdxK	2.7.1.35, 2.7.1.49, 2.7.4.7	-	H	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
MDDHOLLC_00751	5e-26	ywdA	-	-	-	-	-	-	-
MDDHOLLC_00752	0.0	sacA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
MDDHOLLC_00753	1.55e-143	sacP	2.7.1.211	-	G	ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_00754	6.91e-129	sacP	2.7.1.211	-	G	ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_00755	1.91e-195	sacT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MDDHOLLC_00757	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MDDHOLLC_00758	2.32e-236	ywcH	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_00759	4.47e-176	nfrA1	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	Oxidoreductase
MDDHOLLC_00760	7.63e-271	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
MDDHOLLC_00761	1.24e-98	ysnE	-	-	K	ko:K03829	-	ko00000,ko01000	acetyltransferase
MDDHOLLC_00762	2.54e-51	ywcE	-	-	S	-	-	-	Required for proper spore morphogenesis. Important for spore germination
MDDHOLLC_00763	1.31e-81	qoxD	1.10.3.12	-	C	ko:K02829	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
MDDHOLLC_00764	1.33e-141	qoxC	1.10.3.12	-	C	ko:K02828	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
MDDHOLLC_00765	0.0	qoxB	1.10.3.12	-	C	ko:K02827	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MDDHOLLC_00766	3.67e-227	qoxA	1.10.3.12	-	C	ko:K02826	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
MDDHOLLC_00767	5.74e-48	ydaS	-	-	S	-	-	-	membrane
MDDHOLLC_00768	7.82e-140	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MDDHOLLC_00769	5.13e-197	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MDDHOLLC_00770	4.03e-80	gtcA	-	-	S	-	-	-	GtrA-like protein
MDDHOLLC_00771	1.52e-144	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MDDHOLLC_00773	4.8e-115	-	-	-	H	-	-	-	Methionine biosynthesis protein MetW
MDDHOLLC_00774	3.31e-170	-	-	-	S	-	-	-	Streptomycin biosynthesis protein StrF
MDDHOLLC_00775	1.21e-142	ywbO	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
MDDHOLLC_00776	1.54e-309	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Dyp-type peroxidase family protein
MDDHOLLC_00777	4.08e-146	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MDDHOLLC_00778	3.73e-175	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MDDHOLLC_00779	4.83e-202	ywbI	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00780	9.02e-76	ywbH	-	-	S	ko:K06518	-	ko00000,ko02000	Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
MDDHOLLC_00781	7.55e-143	ywbG	-	-	M	-	-	-	effector of murein hydrolase
MDDHOLLC_00782	9.1e-38	ywbE	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2196)
MDDHOLLC_00783	2.21e-178	mta	-	-	K	ko:K21743	-	ko00000,ko03000	transcriptional
MDDHOLLC_00784	3.6e-285	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
MDDHOLLC_00785	1.51e-87	ywbC	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	glyoxalase
MDDHOLLC_00786	6.67e-305	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MDDHOLLC_00787	0.0	epr	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MDDHOLLC_00788	1.42e-205	gspA	-	-	M	-	-	-	General stress
MDDHOLLC_00789	1.76e-64	ywaE	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00790	3.34e-247	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MDDHOLLC_00791	1.85e-151	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	protein conserved in bacteria
MDDHOLLC_00792	7.57e-215	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the MenA family. Type 1 subfamily
MDDHOLLC_00793	7.08e-18	-	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
MDDHOLLC_00794	0.0	dltA	6.1.1.13	-	Q	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_00795	2.56e-293	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	membrane protein involved in D-alanine export
MDDHOLLC_00796	1.96e-49	dltC	6.1.1.13	-	IQ	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_00797	1.79e-288	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MDDHOLLC_00798	9.09e-260	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
MDDHOLLC_00799	0.0	licH	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MDDHOLLC_00800	5.46e-65	licA	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_00801	0.0	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MDDHOLLC_00802	4.46e-66	licB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	transporter subunit IIB
MDDHOLLC_00803	0.0	licR	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
MDDHOLLC_00804	1.32e-144	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
MDDHOLLC_00805	1.91e-219	-	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_00806	9.74e-231	-	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_00807	5.34e-213	cbrA3	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
MDDHOLLC_00808	7.5e-76	arsR	-	-	K	ko:K03892,ko:K22043	-	ko00000,ko03000	transcriptional
MDDHOLLC_00809	2.56e-290	arsB	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MDDHOLLC_00810	2.78e-65	ydhM	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_00811	1.53e-63	ydhN3	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_00812	1.41e-302	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MDDHOLLC_00813	0.0	ydhP	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MDDHOLLC_00814	1.16e-209	gmuE	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	COG1940 Transcriptional regulator sugar kinase
MDDHOLLC_00815	1.58e-238	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MDDHOLLC_00816	8.82e-266	ydhT1	3.2.1.78	GH26	G	ko:K01218	ko00051,ko02024,map00051,map02024	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 26 family
MDDHOLLC_00817	0.0	katX	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MDDHOLLC_00818	7.89e-246	yxeI	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
MDDHOLLC_00819	0.0	yxlA	-	-	F	ko:K03457	-	ko00000	Belongs to the purine-cytosine permease (2.A.39) family
MDDHOLLC_00820	9.85e-198	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MDDHOLLC_00821	0.0	cydD	-	-	V	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding protein
MDDHOLLC_00822	0.0	cydC	-	-	V	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding
MDDHOLLC_00823	5.3e-240	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase, subunit II
MDDHOLLC_00824	3.89e-231	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
MDDHOLLC_00825	9.18e-77	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
MDDHOLLC_00826	5.53e-288	cimH	-	-	C	-	-	-	COG3493 Na citrate symporter
MDDHOLLC_00827	1.1e-196	yxkH	-	-	G	-	-	-	Polysaccharide deacetylase
MDDHOLLC_00828	1.06e-260	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_00829	3.59e-115	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
MDDHOLLC_00830	3.28e-189	yxkD	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MDDHOLLC_00831	2.68e-120	yxkC	-	-	S	-	-	-	Domain of unknown function (DUF4352)
MDDHOLLC_00832	6.27e-248	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MDDHOLLC_00833	5.46e-299	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
MDDHOLLC_00836	1.75e-110	yxjI	-	-	S	-	-	-	LURP-one-related
MDDHOLLC_00837	3e-273	yxjG	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
MDDHOLLC_00838	1.31e-176	yxjB	2.1.1.187	-	Q	ko:K00563	-	ko00000,ko01000,ko03009	Methyltransferase domain
MDDHOLLC_00839	1.65e-266	nupG	-	-	F	ko:K16323	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MDDHOLLC_00840	6.33e-82	-	-	-	T	-	-	-	Domain of unknown function (DUF4163)
MDDHOLLC_00841	3.38e-65	yxiS	-	-	-	-	-	-	-
MDDHOLLC_00842	0.0	katE	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MDDHOLLC_00843	1.57e-281	citH	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
MDDHOLLC_00844	9.11e-182	bglS	-	-	M	-	-	-	licheninase activity
MDDHOLLC_00846	4.9e-136	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MDDHOLLC_00847	3.1e-27	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MDDHOLLC_00848	3.51e-280	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	COG2270 Permeases of the major facilitator superfamily
MDDHOLLC_00849	0.0	dbpA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
MDDHOLLC_00852	4.09e-80	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
MDDHOLLC_00853	8.09e-63	yxiI	-	-	S	-	-	-	Protein of unknown function (DUF2716)
MDDHOLLC_00854	3.15e-15	-	-	-	-	-	-	-	-
MDDHOLLC_00856	5.74e-133	-	-	-	-	-	-	-	-
MDDHOLLC_00859	7.52e-42	yxiG	-	-	-	-	-	-	-
MDDHOLLC_00860	1.3e-81	yxxG	-	-	-	-	-	-	-
MDDHOLLC_00862	2.51e-109	-	-	-	S	-	-	-	Protein of unknown function (DUF4240)
MDDHOLLC_00863	5.86e-148	-	-	-	-	-	-	-	-
MDDHOLLC_00864	0.0	wapA	-	-	M	-	-	-	COG3209 Rhs family protein
MDDHOLLC_00865	6.09e-254	pelB	4.2.2.10, 4.2.2.2	-	G	ko:K01728,ko:K01732	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectate lyase
MDDHOLLC_00866	8.44e-208	yxxF	-	-	EG	-	-	-	EamA-like transporter family
MDDHOLLC_00867	5.98e-95	yxiE	-	-	T	-	-	-	Belongs to the universal stress protein A family
MDDHOLLC_00868	0.0	-	-	-	L	-	-	-	HKD family nuclease
MDDHOLLC_00869	2.39e-85	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MDDHOLLC_00870	0.0	yxiA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
MDDHOLLC_00871	2.45e-103	hutP	-	-	K	ko:K09683	-	ko00000,ko03000	Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
MDDHOLLC_00872	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Histidine ammonia-lyase
MDDHOLLC_00873	0.0	hutU	4.2.1.49	-	E	ko:K01712	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MDDHOLLC_00874	1.44e-295	hutI	3.5.2.7	-	Q	ko:K01468	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Imidazolone-5-propionate hydrolase
MDDHOLLC_00875	2.78e-224	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
MDDHOLLC_00876	0.0	hutM	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MDDHOLLC_00877	1.1e-296	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	phosphorylase
MDDHOLLC_00878	4.04e-265	nupC	-	-	F	ko:K11535	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MDDHOLLC_00879	4.09e-145	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MDDHOLLC_00880	8.24e-220	deoR	-	-	K	ko:K05346	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MDDHOLLC_00881	1.91e-192	yxeH	-	-	S	-	-	-	hydrolases of the HAD superfamily
MDDHOLLC_00884	3.81e-33	yxeE	-	-	-	-	-	-	-
MDDHOLLC_00885	5.09e-35	yxeD	-	-	-	-	-	-	-
MDDHOLLC_00886	4.62e-45	-	-	-	-	-	-	-	-
MDDHOLLC_00887	1.68e-157	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
MDDHOLLC_00888	7.17e-58	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
MDDHOLLC_00889	4.9e-76	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
MDDHOLLC_00890	0.0	yxdM	-	-	V	ko:K11636	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MDDHOLLC_00891	1.89e-181	yxdL	-	-	V	ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_00892	6.53e-223	yxdK	2.7.13.3	-	T	ko:K11633	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00893	9.37e-159	yxdJ	-	-	T	ko:K11634	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00894	2.49e-198	fbaA	4.1.2.13, 4.1.2.29	-	F	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
MDDHOLLC_00895	1.7e-200	iolI	5.3.99.11	-	G	ko:K06606	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
MDDHOLLC_00896	6.24e-212	iolH	-	-	G	ko:K06605	-	ko00000	Xylose isomerase-like TIM barrel
MDDHOLLC_00897	1.17e-246	iolG	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
MDDHOLLC_00898	5.22e-294	iolF	-	-	EGP	ko:K06610	-	ko00000,ko02000	Major facilitator superfamily
MDDHOLLC_00899	3.12e-221	iolE	4.2.1.44	-	H	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
MDDHOLLC_00900	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
MDDHOLLC_00901	3.82e-229	iolC	2.7.1.92	-	G	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
MDDHOLLC_00902	1.15e-198	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
MDDHOLLC_00903	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MDDHOLLC_00904	1.75e-174	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MDDHOLLC_00905	1.95e-221	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
MDDHOLLC_00906	6.38e-313	csbC	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MDDHOLLC_00907	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Molecular chaperone. Has ATPase activity
MDDHOLLC_00909	7.18e-194	yxbG	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MDDHOLLC_00910	3.57e-130	desR	-	-	T	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_00911	5.85e-255	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00912	4.62e-251	des	1.14.19.23, 1.14.19.45	-	I	ko:K10255	ko02020,map02020	ko00000,ko00001,ko01000,ko01004	fatty acid desaturase
MDDHOLLC_00913	4.26e-272	yxbF	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MDDHOLLC_00914	9.34e-317	aldX	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MDDHOLLC_00915	1.45e-190	yxaL	-	-	S	-	-	-	PQQ-like domain
MDDHOLLC_00916	1.02e-84	-	-	-	S	-	-	-	Family of unknown function (DUF5391)
MDDHOLLC_00917	1.21e-67	arsR3	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MDDHOLLC_00918	3.12e-255	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MDDHOLLC_00919	1.84e-95	yxaI	-	-	S	-	-	-	membrane protein domain
MDDHOLLC_00920	2.59e-160	-	-	-	E	-	-	-	Ring-cleavage extradiol dioxygenase
MDDHOLLC_00921	1.62e-313	-	-	-	L	-	-	-	COG0210 Superfamily I DNA and RNA helicases
MDDHOLLC_00922	1.93e-05	htpX3	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	COG0501 Zn-dependent protease with chaperone function
MDDHOLLC_00923	2.94e-116	mrr2	-	-	V	ko:K07448	-	ko00000,ko02048	Mrr N-terminal domain
MDDHOLLC_00924	1.61e-136	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	Alkyl hydroperoxide reductase
MDDHOLLC_00925	0.0	ahpF	-	-	O	ko:K03387	-	ko00000,ko01000	Alkyl hydroperoxide reductase
MDDHOLLC_00926	4.32e-313	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_00927	0.0	fbp	3.1.3.11	-	G	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Firmicute fructose-1,6-bisphosphatase
MDDHOLLC_00928	4.73e-108	pucE	1.2.5.3	-	C	ko:K03518	-	ko00000,ko01000	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
MDDHOLLC_00929	5.24e-195	-	-	-	C	-	-	-	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
MDDHOLLC_00930	0.0	-	-	-	C	-	-	-	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
MDDHOLLC_00931	1.02e-146	-	-	-	C	-	-	-	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
MDDHOLLC_00932	1.15e-113	pucB	1.17.1.4, 2.7.7.76	-	S	ko:K00087,ko:K07141	ko00230,ko00790,ko01100,ko01120,map00230,map00790,map01100,map01120	ko00000,ko00001,ko00002,ko01000	MobA-like NTP transferase domain
MDDHOLLC_00933	6.1e-232	pucA	1.17.1.4	-	O	ko:K00087,ko:K07402	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MDDHOLLC_00934	1.18e-229	-	-	-	S	-	-	-	Fusaric acid resistance protein-like
MDDHOLLC_00935	3.77e-111	-	-	-	-	-	-	-	-
MDDHOLLC_00937	1.75e-203	rarA	-	-	L	ko:K07478	-	ko00000	atpase related to the helicase subunit of the holliday junction resolvase
MDDHOLLC_00938	1.2e-48	-	-	-	-	-	-	-	-
MDDHOLLC_00939	1.01e-105	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MDDHOLLC_00943	4.59e-270	yycP	-	-	-	-	-	-	-
MDDHOLLC_00944	2.97e-156	yycO	-	-	S	-	-	-	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MDDHOLLC_00945	9.76e-230	-	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
MDDHOLLC_00946	1.19e-112	yycN	-	-	K	-	-	-	Acetyltransferase
MDDHOLLC_00948	3.7e-259	-	-	-	S	ko:K06361,ko:K06365,ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
MDDHOLLC_00949	2.64e-212	rocF	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
MDDHOLLC_00950	0.0	rocE	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MDDHOLLC_00951	3.94e-294	rocD	2.6.1.13	-	E	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Catalyzes the interconversion of ornithine to glutamate semialdehyde
MDDHOLLC_00952	5.39e-57	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
MDDHOLLC_00953	4.83e-16	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
MDDHOLLC_00954	2.69e-57	sdpR	-	-	K	-	-	-	transcriptional
MDDHOLLC_00955	0.0	rocR	-	-	KT	ko:K06714	-	ko00000,ko03000	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
MDDHOLLC_00956	7.53e-188	-	1.14.11.27	-	P	ko:K10277	-	ko00000,ko01000,ko03036	peptidyl-arginine hydroxylation
MDDHOLLC_00957	5.04e-67	-	-	-	S	-	-	-	ABC transporter
MDDHOLLC_00958	1.08e-276	-	-	-	S	-	-	-	ABC transporter
MDDHOLLC_00959	1.52e-251	-	-	-	S	-	-	-	Major Facilitator Superfamily
MDDHOLLC_00960	0.0	-	-	-	-	-	-	-	-
MDDHOLLC_00961	8e-65	thiF	2.7.7.73	-	H	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	ThiF family
MDDHOLLC_00962	5.8e-146	thiF	2.7.7.73	-	H	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	ThiF family
MDDHOLLC_00963	2.06e-314	-	2.7.13.3	-	T	ko:K02484	-	ko00000,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MDDHOLLC_00964	1.34e-13	phoP1	-	-	KT	ko:K02483	-	ko00000,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00965	4.47e-276	yyxA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MDDHOLLC_00966	1.98e-191	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
MDDHOLLC_00967	1.98e-194	yycI	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00968	0.0	yycH	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_00969	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_00970	6.92e-150	yycF	-	-	T	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_00975	1.55e-315	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MDDHOLLC_00976	1.29e-93	yycE	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_00977	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
MDDHOLLC_00978	6.11e-36	yycD	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
MDDHOLLC_00980	5.12e-25	yycC	-	-	K	-	-	-	YycC-like protein
MDDHOLLC_00981	7.81e-300	-	-	-	M	-	-	-	Glycosyltransferase Family 4
MDDHOLLC_00982	3.03e-257	-	-	-	S	-	-	-	Ecdysteroid kinase
MDDHOLLC_00983	1.27e-294	-	-	-	S	-	-	-	Carbamoyl-phosphate synthase L chain, ATP binding domain
MDDHOLLC_00984	2.77e-307	-	-	-	M	-	-	-	Glycosyltransferase Family 4
MDDHOLLC_00985	2.15e-157	-	-	-	S	-	-	-	GlcNAc-PI de-N-acetylase
MDDHOLLC_00986	2.06e-158	-	-	-	KLT	-	-	-	COG0515 Serine threonine protein kinase
MDDHOLLC_00987	1.58e-95	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MDDHOLLC_00988	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
MDDHOLLC_00989	2.48e-204	yybS	-	-	S	-	-	-	membrane
MDDHOLLC_00991	2.25e-109	cotF	-	-	M	ko:K06329	-	ko00000	Spore coat protein
MDDHOLLC_00992	2.64e-86	yybR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_00993	2.42e-210	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
MDDHOLLC_00994	4.82e-196	ypaH	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MDDHOLLC_00995	0.0	sacB	2.4.1.10, 2.4.1.9	GH68	M	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	levansucrase activity
MDDHOLLC_00996	0.0	sacC3	3.2.1.65	GH32	G	ko:K01212	ko00500,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
MDDHOLLC_00997	5.42e-149	-	-	-	K	-	-	-	FCD domain
MDDHOLLC_00998	2.74e-117	-	-	-	S	-	-	-	PFAM DinB family protein
MDDHOLLC_00999	5.9e-202	-	-	-	G	-	-	-	Major Facilitator Superfamily
MDDHOLLC_01000	1.12e-73	ypaA	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
MDDHOLLC_01001	1.7e-148	ydgI	-	-	C	-	-	-	nitroreductase
MDDHOLLC_01002	1.03e-46	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MDDHOLLC_01003	3.35e-32	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MDDHOLLC_01004	1.09e-193	ydeO	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_01005	1.85e-99	yybA	-	-	K	-	-	-	transcriptional
MDDHOLLC_01006	2.56e-55	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_01007	3.12e-08	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_01008	6.47e-209	-	-	-	M	-	-	-	Domain of Unknown Function (DUF1259)
MDDHOLLC_01009	1.6e-85	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
MDDHOLLC_01010	1.15e-208	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01011	9.57e-176	bdh	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MDDHOLLC_01012	8.62e-317	ydfD	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MDDHOLLC_01013	4.7e-165	-	-	-	EG	-	-	-	EamA-like transporter family
MDDHOLLC_01014	1.44e-128	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MDDHOLLC_01015	1.76e-101	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01016	2.32e-52	ebrA	-	-	U	ko:K11814	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MDDHOLLC_01017	0.0	yyaL	-	-	O	ko:K06888	-	ko00000	COG1331 Highly conserved protein containing a thioredoxin domain
MDDHOLLC_01018	2.33e-207	yyaK	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
MDDHOLLC_01019	1.03e-315	-	-	-	G	ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
MDDHOLLC_01020	5.7e-87	yyaH	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_01021	1.62e-230	ccpB	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01022	8.69e-180	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
MDDHOLLC_01023	3.79e-125	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MDDHOLLC_01024	2.1e-135	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
MDDHOLLC_01025	1.11e-49	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MDDHOLLC_01026	4.77e-99	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MDDHOLLC_01027	2.9e-61	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
MDDHOLLC_01028	5.42e-254	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MDDHOLLC_01029	0.0	yyaE	-	-	C	-	-	-	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MDDHOLLC_01030	1.82e-45	yyzM	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01031	2.37e-225	yyaD	-	-	S	-	-	-	Membrane
MDDHOLLC_01033	1.35e-63	yhhY	-	-	K	-	-	-	FR47-like protein
MDDHOLLC_01034	4.91e-144	yyaC	-	-	S	-	-	-	Sporulation protein YyaC
MDDHOLLC_01035	1.43e-189	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
MDDHOLLC_01036	2.49e-172	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	COG1192 ATPases involved in chromosome partitioning
MDDHOLLC_01037	6.61e-195	noc	-	-	D	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
MDDHOLLC_01038	4.62e-164	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
MDDHOLLC_01039	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MDDHOLLC_01040	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MDDHOLLC_01041	4.45e-140	jag	-	-	S	ko:K06346	-	ko00000	single-stranded nucleic acid binding R3H
MDDHOLLC_01042	2.12e-179	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MDDHOLLC_01043	1.99e-71	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MDDHOLLC_01044	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MDDHOLLC_01045	8.12e-262	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MDDHOLLC_01046	3.19e-45	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain
MDDHOLLC_01047	1.52e-262	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MDDHOLLC_01048	1.03e-50	yaaB	-	-	S	-	-	-	Domain of unknown function (DUF370)
MDDHOLLC_01049	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDDHOLLC_01050	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDDHOLLC_01051	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01054	2.82e-233	yaaC	-	-	S	-	-	-	YaaC-like Protein
MDDHOLLC_01055	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MDDHOLLC_01056	0.0	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MDDHOLLC_01057	1.29e-202	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MDDHOLLC_01058	9.58e-138	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MDDHOLLC_01059	1.85e-284	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MDDHOLLC_01060	6.06e-254	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
MDDHOLLC_01062	1.46e-156	dck	2.7.1.74, 2.7.1.76	-	F	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko01000	Deoxycytidine kinase
MDDHOLLC_01063	3.88e-147	dgk	2.7.1.113	-	F	ko:K15518	ko00230,map00230	ko00000,ko00001,ko01000	Deoxyguanosine kinase
MDDHOLLC_01064	2.49e-278	yaaH	-	-	M	ko:K06306	-	ko00000	Glycoside Hydrolase Family
MDDHOLLC_01065	2.04e-16	yaaI	-	-	Q	-	-	-	COG1335 Amidases related to nicotinamidase
MDDHOLLC_01066	1.18e-109	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MDDHOLLC_01067	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDDHOLLC_01068	6.9e-52	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MDDHOLLC_01069	6e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MDDHOLLC_01070	5.4e-43	yaaL	-	-	S	-	-	-	Protein of unknown function (DUF2508)
MDDHOLLC_01071	3.73e-49	bofA	-	-	S	ko:K06317	-	ko00000	Sigma-K factor-processing regulatory protein BofA
MDDHOLLC_01072	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01075	1.82e-41	csfB	-	-	S	-	-	-	Inhibitor of sigma-G Gin
MDDHOLLC_01076	4.86e-135	xpaC	-	-	S	-	-	-	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MDDHOLLC_01077	1.56e-240	yaaN	-	-	P	-	-	-	Belongs to the TelA family
MDDHOLLC_01078	0.0	yaaO	-	-	E	-	-	-	Orn Lys Arg decarboxylase
MDDHOLLC_01079	2.22e-144	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MDDHOLLC_01080	5.03e-73	yaaQ	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01081	8.53e-65	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
MDDHOLLC_01082	2.2e-18	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
MDDHOLLC_01083	2.82e-235	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
MDDHOLLC_01084	9e-189	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
MDDHOLLC_01085	3.08e-56	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
MDDHOLLC_01086	8.05e-178	yabB	2.1.1.223	-	S	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Conserved hypothetical protein 95
MDDHOLLC_01087	1.16e-62	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
MDDHOLLC_01088	1.58e-207	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MDDHOLLC_01089	6.14e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	COG2002 Regulators of stationary sporulation gene expression
MDDHOLLC_01090	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDDHOLLC_01091	2.49e-183	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD
MDDHOLLC_01092	2.38e-308	yabE	-	-	T	-	-	-	protein conserved in bacteria
MDDHOLLC_01093	7.62e-126	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MDDHOLLC_01094	2.07e-203	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MDDHOLLC_01095	1.4e-76	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
MDDHOLLC_01096	4.42e-101	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
MDDHOLLC_01097	5.32e-53	veg	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01098	7.31e-38	sspF	-	-	S	ko:K06423	-	ko00000	DNA topological change
MDDHOLLC_01099	7.83e-206	ispE	2.7.1.148	-	I	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MDDHOLLC_01100	5.67e-197	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
MDDHOLLC_01101	7.5e-83	yabJ	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	translation initiation inhibitor, yjgF family
MDDHOLLC_01102	4.23e-64	spoVG	-	-	D	ko:K06412	-	ko00000	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
MDDHOLLC_01103	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MDDHOLLC_01104	2.47e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MDDHOLLC_01105	7.21e-136	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MDDHOLLC_01106	1.74e-136	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MDDHOLLC_01107	1.1e-54	yabK	-	-	S	-	-	-	Peptide ABC transporter permease
MDDHOLLC_01108	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MDDHOLLC_01109	6.58e-25	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein T
MDDHOLLC_01110	7.79e-70	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein
MDDHOLLC_01111	0.0	yabM	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_01112	0.0	yabN	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
MDDHOLLC_01113	1.42e-48	yabO	-	-	J	-	-	-	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
MDDHOLLC_01114	5.47e-66	yabP	-	-	S	-	-	-	Sporulation protein YabP
MDDHOLLC_01115	9.66e-134	yabQ	-	-	S	-	-	-	spore cortex biosynthesis protein
MDDHOLLC_01116	1.2e-74	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
MDDHOLLC_01117	3.54e-82	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
MDDHOLLC_01120	0.0	spoIIE	3.1.3.16	-	KT	ko:K06382	-	ko00000,ko01000	stage II sporulation protein E
MDDHOLLC_01121	3.79e-166	yabS	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MDDHOLLC_01122	1.34e-235	yabT	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	serine threonine protein kinase
MDDHOLLC_01123	0.0	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MDDHOLLC_01124	1.05e-119	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
MDDHOLLC_01125	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MDDHOLLC_01126	2.59e-128	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MDDHOLLC_01127	1.54e-42	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MDDHOLLC_01128	1.3e-205	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MDDHOLLC_01129	5.7e-145	yacD	5.2.1.8	-	O	ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl isomerase
MDDHOLLC_01130	7.3e-216	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
MDDHOLLC_01131	0.0	pabB	2.6.1.85	-	EH	ko:K01665	ko00790,map00790	ko00000,ko00001,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MDDHOLLC_01132	1.79e-137	pabA	2.6.1.85	-	EH	ko:K01664	ko00790,map00790	ko00000,ko00001,ko01000	Anthranilate synthase
MDDHOLLC_01133	4.03e-206	pabC	4.1.3.38	-	EH	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	4-amino-4-deoxychorismate lyase
MDDHOLLC_01134	3.06e-201	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MDDHOLLC_01135	1.13e-81	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MDDHOLLC_01136	7.88e-116	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MDDHOLLC_01137	6.1e-40	yazB	-	-	K	-	-	-	transcriptional
MDDHOLLC_01138	3.59e-240	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MDDHOLLC_01139	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
MDDHOLLC_01140	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01141	9.67e-66	-	-	-	S	-	-	-	COG NOG14600 non supervised orthologous group
MDDHOLLC_01151	2.14e-100	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
MDDHOLLC_01152	1.89e-82	mcsA	-	-	S	ko:K19411	-	ko00000	protein with conserved CXXC pairs
MDDHOLLC_01153	1.63e-258	mcsB	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
MDDHOLLC_01154	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
MDDHOLLC_01155	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MDDHOLLC_01156	2e-209	disA	2.7.7.85	-	L	ko:K07067	-	ko00000,ko01000	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MDDHOLLC_01157	8.6e-251	yacL	-	-	S	-	-	-	COG4956 Integral membrane protein (PIN domain superfamily)
MDDHOLLC_01158	1.01e-159	ispD	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MDDHOLLC_01159	3.02e-111	ispF	2.7.7.60, 4.6.1.12	-	I	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MDDHOLLC_01160	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MDDHOLLC_01161	1.91e-152	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
MDDHOLLC_01162	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
MDDHOLLC_01163	1.52e-75	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MDDHOLLC_01164	1.01e-172	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MDDHOLLC_01165	4.03e-115	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
MDDHOLLC_01166	1.39e-150	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
MDDHOLLC_01167	3.77e-32	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MDDHOLLC_01168	1.28e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
MDDHOLLC_01169	3.4e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MDDHOLLC_01170	8.66e-161	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MDDHOLLC_01171	8.13e-104	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MDDHOLLC_01172	2.84e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MDDHOLLC_01173	5.82e-68	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
MDDHOLLC_01174	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDDHOLLC_01175	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDDHOLLC_01176	5.94e-46	rplGB	-	-	J	ko:K07590	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the eukaryotic ribosomal protein eL8 family
MDDHOLLC_01177	9.27e-69	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MDDHOLLC_01178	4.85e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MDDHOLLC_01179	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MDDHOLLC_01180	9.55e-286	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MDDHOLLC_01181	5.91e-233	ybaC	-	-	S	-	-	-	Alpha/beta hydrolase family
MDDHOLLC_01182	2.58e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
MDDHOLLC_01183	1.02e-143	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MDDHOLLC_01184	2.59e-136	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
MDDHOLLC_01185	3.27e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MDDHOLLC_01186	9.5e-201	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MDDHOLLC_01187	2.83e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MDDHOLLC_01188	9.23e-71	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MDDHOLLC_01189	1.69e-151	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MDDHOLLC_01190	1.38e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MDDHOLLC_01191	1.88e-35	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
MDDHOLLC_01192	1.64e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MDDHOLLC_01193	1.04e-78	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MDDHOLLC_01194	1.43e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MDDHOLLC_01195	5.43e-122	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MDDHOLLC_01196	1.43e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MDDHOLLC_01197	1.08e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MDDHOLLC_01198	3.14e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MDDHOLLC_01199	8.29e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MDDHOLLC_01200	4.54e-111	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MDDHOLLC_01201	1.59e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
MDDHOLLC_01202	2.1e-94	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MDDHOLLC_01203	3.15e-295	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MDDHOLLC_01204	4.34e-158	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MDDHOLLC_01205	2.71e-181	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
MDDHOLLC_01206	2.92e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MDDHOLLC_01207	2.45e-19	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
MDDHOLLC_01208	1.54e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MDDHOLLC_01209	4.61e-84	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MDDHOLLC_01210	4.94e-217	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MDDHOLLC_01211	4.27e-77	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
MDDHOLLC_01212	3.05e-199	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDDHOLLC_01213	4.91e-190	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDDHOLLC_01214	2.77e-178	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDDHOLLC_01215	1.69e-179	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MDDHOLLC_01216	6.54e-102	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MDDHOLLC_01217	8.64e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
MDDHOLLC_01218	1.02e-184	ybaJ	-	-	Q	-	-	-	Methyltransferase domain
MDDHOLLC_01219	3.15e-108	yizA	-	-	S	-	-	-	Damage-inducible protein DinB
MDDHOLLC_01220	3.1e-101	ybaK	-	-	S	-	-	-	Protein of unknown function (DUF2521)
MDDHOLLC_01221	5.68e-173	cwlD	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MDDHOLLC_01222	6.33e-254	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MDDHOLLC_01223	1.37e-49	gerD	-	-	-	ko:K06294	-	ko00000	-
MDDHOLLC_01224	4.19e-133	kbaA	-	-	S	ko:K06349	-	ko00000	Involved in the activation of the KinB signaling pathway of sporulation
MDDHOLLC_01225	1.23e-180	pdaB	-	-	G	-	-	-	Polysaccharide deacetylase
MDDHOLLC_01226	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01232	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01233	3.69e-58	-	-	-	-	-	-	-	-
MDDHOLLC_01234	1.1e-279	glcP1	-	-	G	ko:K08174	-	ko00000,ko02000	Major Facilitator Superfamily
MDDHOLLC_01235	5.18e-313	gabT	2.6.1.19	-	E	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MDDHOLLC_01236	1.44e-226	suhB	3.1.3.25, 3.1.3.7	-	G	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	ko00000,ko00001,ko00002,ko01000,ko03016	inositol monophosphate 1-phosphatase activity
MDDHOLLC_01237	2.8e-256	-	1.1.1.14, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
MDDHOLLC_01238	3.19e-287	ybaR	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
MDDHOLLC_01239	2.09e-220	ybaS	-	-	S	-	-	-	Na -dependent transporter
MDDHOLLC_01240	5.57e-125	ybbA	-	-	S	ko:K07017	-	ko00000	Putative esterase
MDDHOLLC_01241	2.37e-228	feuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_01242	4.42e-226	feuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_01243	2.1e-220	feuA	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Iron-uptake system-binding protein
MDDHOLLC_01244	0.0	ybbB	-	-	K	ko:K21701	-	ko00000,ko03000	COG2207 AraC-type DNA-binding domain-containing proteins
MDDHOLLC_01245	3.55e-297	ybbC	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01246	0.0	ybbD	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
MDDHOLLC_01247	4.62e-311	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the UPF0214 family
MDDHOLLC_01248	4.31e-312	ybbF	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_01249	6.37e-206	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MDDHOLLC_01250	1.01e-109	ybbJ	-	-	J	-	-	-	acetyltransferase
MDDHOLLC_01251	6.45e-100	ybbK	-	-	S	-	-	-	Protein of unknown function (DUF523)
MDDHOLLC_01257	4.59e-127	sigW	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01258	3.19e-151	rsiW	-	-	K	-	-	-	Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
MDDHOLLC_01259	9e-188	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MDDHOLLC_01260	1.05e-299	ybbR	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01261	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MDDHOLLC_01262	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MDDHOLLC_01263	1.18e-196	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MDDHOLLC_01264	9.81e-87	-	-	-	S	-	-	-	ABC-2 family transporter protein
MDDHOLLC_01265	7.37e-32	-	-	-	S	-	-	-	ABC-2 family transporter protein
MDDHOLLC_01266	9.2e-126	ybdN	-	-	-	-	-	-	-
MDDHOLLC_01267	1.06e-165	ybdO	-	-	S	-	-	-	Domain of unknown function (DUF4885)
MDDHOLLC_01268	2.43e-205	dkgB	-	-	S	-	-	-	Aldo/keto reductase family
MDDHOLLC_01269	6.05e-135	yxaC	-	-	M	-	-	-	effector of murein hydrolase
MDDHOLLC_01270	9.9e-68	-	-	-	S	ko:K06518	-	ko00000,ko02000	LrgA family
MDDHOLLC_01271	5.62e-93	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_01272	0.0	ybxG	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_01273	7.56e-119	yfnB	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
MDDHOLLC_01274	9.07e-197	-	-	-	T	-	-	-	COG4585 Signal transduction histidine kinase
MDDHOLLC_01275	1.23e-142	yfiK	-	-	KT	ko:K02479	-	ko00000,ko02022	LuxR family transcriptional regulator
MDDHOLLC_01276	4.19e-212	yfiL	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
MDDHOLLC_01277	8.33e-259	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
MDDHOLLC_01278	2.72e-245	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
MDDHOLLC_01279	1.87e-32	-	-	-	-	-	-	-	-
MDDHOLLC_01280	6.33e-104	-	-	-	S	-	-	-	Domain of unknown function (DUF4879)
MDDHOLLC_01281	7.13e-52	csgA	-	-	S	-	-	-	Sigma-G-dependent sporulation-specific SASP protein
MDDHOLLC_01282	2.06e-143	yqeB	-	-	-	-	-	-	-
MDDHOLLC_01283	7.84e-55	ybyB	-	-	-	-	-	-	-
MDDHOLLC_01284	0.0	ybeC	-	-	E	-	-	-	amino acid
MDDHOLLC_01285	4.93e-212	glpQ	3.1.3.1, 3.1.4.46	-	C	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	glycerophosphoryl diester phosphodiesterase
MDDHOLLC_01286	0.0	glpT	-	-	G	ko:K02445	-	ko00000,ko02000	-transporter
MDDHOLLC_01287	4.08e-23	-	-	-	S	-	-	-	Protein of unknown function (DUF2651)
MDDHOLLC_01288	1.36e-265	yoaI	1.14.14.9	-	Q	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	ko00000,ko00001,ko01000	COG2368 Aromatic ring hydroxylase
MDDHOLLC_01290	0.0	ybfG	-	-	M	-	-	-	Domain of unknown function (DUF1906)
MDDHOLLC_01291	1.05e-46	-	-	-	-	-	-	-	-
MDDHOLLC_01292	1.69e-107	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MDDHOLLC_01293	1.26e-247	ypjH	-	-	C	ko:K08317	-	ko00000,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
MDDHOLLC_01294	2.66e-270	purT	2.1.2.2	-	F	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MDDHOLLC_01295	3.15e-120	pssA	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MDDHOLLC_01296	4.26e-113	ybfM	-	-	S	-	-	-	SNARE associated Golgi protein
MDDHOLLC_01297	1.45e-192	psd	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
MDDHOLLC_01298	7.41e-56	ybfN	-	-	-	-	-	-	-
MDDHOLLC_01299	9.56e-244	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
MDDHOLLC_01300	1.59e-269	gltP	-	-	C	ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MDDHOLLC_01301	2.05e-255	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
MDDHOLLC_01302	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MDDHOLLC_01303	2.4e-229	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine
MDDHOLLC_01304	0.0	agcS	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
MDDHOLLC_01305	3.06e-238	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
MDDHOLLC_01306	7.76e-273	glnJ	2.7.13.3	-	T	ko:K07717	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_01307	4.77e-220	glnL	-	-	T	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Regulator
MDDHOLLC_01308	1.96e-157	ycbJ	-	-	S	ko:K06979	-	br01600,ko00000,ko00002,ko01504	Macrolide 2'-phosphotransferase
MDDHOLLC_01309	2.81e-34	rtpA	-	-	K	-	-	-	Tryptophan RNA-binding attenuator protein inhibitory protein
MDDHOLLC_01310	7.1e-197	ydfM	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDDHOLLC_01311	1.57e-141	ydfN	-	-	C	ko:K15976	-	ko00000,ko01000	nitroreductase
MDDHOLLC_01312	1.76e-234	ydfO	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MDDHOLLC_01313	1.14e-83	ydfP	-	-	S	ko:K15977	-	ko00000	DoxX
MDDHOLLC_01314	5.37e-74	ydfQ	-	-	CO	-	-	-	Thioredoxin
MDDHOLLC_01315	1.63e-82	ycbP	-	-	S	-	-	-	Protein of unknown function (DUF2512)
MDDHOLLC_01316	1.75e-100	cwlJ	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell wall
MDDHOLLC_01317	0.0	phoD	3.1.3.1	-	P	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG3540 Phosphodiesterase alkaline phosphatase D
MDDHOLLC_01318	8.68e-36	tatAD	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MDDHOLLC_01319	4.55e-156	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MDDHOLLC_01320	1.91e-151	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MDDHOLLC_01321	3.71e-261	ycbU	-	-	E	-	-	-	Selenocysteine lyase
MDDHOLLC_01322	2.5e-313	lmrB	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	the major facilitator superfamily
MDDHOLLC_01323	1.48e-128	lmrA	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
MDDHOLLC_01324	4.05e-247	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
MDDHOLLC_01325	8.07e-148	lip	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MDDHOLLC_01326	1.61e-250	yccF	-	-	K	ko:K07039	-	ko00000	SEC-C motif
MDDHOLLC_01327	3.62e-217	yccK	-	-	C	-	-	-	Aldo keto reductase
MDDHOLLC_01328	2.66e-225	ycdA	-	-	S	-	-	-	Domain of unknown function (DUF5105)
MDDHOLLC_01329	0.0	ycdB	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01330	0.0	ycdC	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01331	4.94e-119	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
MDDHOLLC_01332	2.86e-248	rapJ	-	-	S	ko:K06368	-	ko00000,ko01000	Response regulator aspartate phosphatase
MDDHOLLC_01333	4.28e-179	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
MDDHOLLC_01334	0.0	malL	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
MDDHOLLC_01335	8.57e-213	adcA	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
MDDHOLLC_01336	1.57e-132	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MDDHOLLC_01337	6.86e-174	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MDDHOLLC_01338	3.3e-235	yceB	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_01339	4.06e-140	yceC	3.5.4.33	-	T	ko:K11991	-	ko00000,ko01000,ko03016	proteins involved in stress response, homologs of TerZ and
MDDHOLLC_01340	7.32e-136	yceD	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
MDDHOLLC_01341	2.46e-138	yceE	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
MDDHOLLC_01342	2.12e-178	yceF	-	-	P	ko:K05794	-	ko00000	Protein of unknown function (DUF475)
MDDHOLLC_01343	0.0	yceG	-	-	S	-	-	-	Putative component of 'biosynthetic module'
MDDHOLLC_01344	3.9e-245	yceH	-	-	P	-	-	-	Belongs to the TelA family
MDDHOLLC_01345	6.09e-275	yceI	-	-	P	ko:K08369	-	ko00000,ko02000	Uncharacterised MFS-type transporter YbfB
MDDHOLLC_01346	7.71e-294	opuAA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
MDDHOLLC_01347	2.45e-185	opuAB	-	-	P	ko:K02001	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
MDDHOLLC_01348	1.16e-209	opuAC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
MDDHOLLC_01349	1.15e-216	amhX	-	-	S	ko:K14665	-	ko00000,ko01000,ko01002	amidohydrolase
MDDHOLLC_01350	1.38e-17	amhX	-	-	S	ko:K14665	-	ko00000,ko01000,ko01002	amidohydrolase
MDDHOLLC_01351	1.48e-289	ycgA	-	-	S	-	-	-	Membrane
MDDHOLLC_01352	2.55e-105	ycgB	-	-	-	-	-	-	-
MDDHOLLC_01353	3.01e-68	-	-	-	L	-	-	-	transposase activity
MDDHOLLC_01354	1.75e-151	-	-	-	L	ko:K07497	-	ko00000	Molecular Function DNA binding, Biological Process DNA recombination
MDDHOLLC_01355	0.0	amyE	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	alpha-amylase
MDDHOLLC_01356	1.09e-226	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
MDDHOLLC_01357	0.0	mdr	-	-	EGP	-	-	-	the major facilitator superfamily
MDDHOLLC_01358	6.92e-101	ycgE	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_01359	1.11e-147	ycgF	-	-	E	-	-	-	Lysine exporter protein LysE YggA
MDDHOLLC_01360	2.52e-193	yqcI	-	-	S	ko:K09190	-	ko00000	YqcI/YcgG family
MDDHOLLC_01361	3.84e-313	ycgH	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_01362	1.31e-145	ycgI	-	-	S	ko:K09967	-	ko00000	Domain of unknown function (DUF1989)
MDDHOLLC_01363	1.29e-191	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MDDHOLLC_01364	6.96e-07	-	-	-	S	-	-	-	Bacillus cereus group antimicrobial protein
MDDHOLLC_01365	1.12e-139	tmrB	-	-	S	-	-	-	AAA domain
MDDHOLLC_01366	8.8e-185	-	4.2.1.118	-	G	ko:K15652	ko00400,ko01110,ko01130,map00400,map01110,map01130	ko00000,ko00001,ko01000	Xylose isomerase-like TIM barrel
MDDHOLLC_01367	5.31e-213	-	-	-	G	ko:K08191,ko:K08194	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_01368	8.64e-136	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MDDHOLLC_01369	1.29e-128	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
MDDHOLLC_01370	3.95e-46	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
MDDHOLLC_01371	1.24e-188	ycgL	-	-	S	ko:K07074	-	ko00000	Predicted nucleotidyltransferase
MDDHOLLC_01372	3.91e-216	ycgM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
MDDHOLLC_01373	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
MDDHOLLC_01374	7.72e-312	putP	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MDDHOLLC_01375	1.43e-290	ycgP	-	-	QT	-	-	-	COG2508 Regulator of polyketide synthase expression
MDDHOLLC_01376	2.01e-185	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
MDDHOLLC_01377	3.45e-35	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
MDDHOLLC_01378	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
MDDHOLLC_01379	3.45e-74	nasE	1.7.1.15	-	P	ko:K00363	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite reductase
MDDHOLLC_01380	0.0	nasD	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MDDHOLLC_01381	1.59e-286	yciC	-	-	S	-	-	-	GTPases (G3E family)
MDDHOLLC_01382	2.14e-282	fdh	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MDDHOLLC_01383	1.78e-47	yckC	-	-	S	-	-	-	membrane
MDDHOLLC_01384	1.42e-31	yckC	-	-	S	-	-	-	membrane
MDDHOLLC_01385	1.46e-64	-	-	-	S	-	-	-	Protein of unknown function (DUF2680)
MDDHOLLC_01386	1.58e-13	yckE	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MDDHOLLC_01387	1.27e-86	nin	-	-	S	-	-	-	Competence protein J (ComJ)
MDDHOLLC_01388	1.88e-101	nucA	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
MDDHOLLC_01389	3.11e-124	hxlB	5.3.1.27	-	G	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
MDDHOLLC_01390	8.64e-137	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	3-hexulose-6-phosphate synthase
MDDHOLLC_01391	3.56e-82	hxlR	-	-	K	-	-	-	transcriptional
MDDHOLLC_01392	0.0	srfAA	-	-	Q	ko:K15654,ko:K15655,ko:K16119	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_01393	0.0	srfAB	-	-	Q	ko:K15654,ko:K15655,ko:K16120	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_01394	0.0	srfAC	-	-	Q	ko:K15656,ko:K16121	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	COG1020 Non-ribosomal peptide synthetase modules and related proteins
MDDHOLLC_01395	6.15e-180	srfAD	-	-	Q	ko:K15657	ko02024,map02024	ko00000,ko00001,ko01008	thioesterase
MDDHOLLC_01396	2.86e-316	-	-	-	E	-	-	-	Aminotransferase class I and II
MDDHOLLC_01397	5.28e-167	sfp	-	-	H	ko:K06133	ko00770,map00770	ko00000,ko00001,ko01000	Belongs to the P-Pant transferase superfamily
MDDHOLLC_01398	9.99e-141	yczE	-	-	S	ko:K07149	-	ko00000	membrane
MDDHOLLC_01399	3.95e-169	tcyC	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MDDHOLLC_01400	4.99e-154	tcyB	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MDDHOLLC_01401	2.8e-187	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
MDDHOLLC_01402	5.96e-206	yclA	-	-	K	ko:K21755	-	ko00000,ko03000	LysR substrate binding domain
MDDHOLLC_01403	3.44e-130	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
MDDHOLLC_01404	0.0	yclC	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182,ko:K16874	ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
MDDHOLLC_01405	4.71e-51	-	4.1.1.61	-	S	ko:K21759	ko00627,ko01120,ko01220,map00627,map01120,map01220	ko00000,ko00001,ko01000	response to toxic substance
MDDHOLLC_01406	9.68e-100	yclD	-	-	-	-	-	-	-
MDDHOLLC_01407	0.0	dtpT	-	-	E	ko:K03305	-	ko00000	amino acid peptide transporter
MDDHOLLC_01408	0.0	yclG	-	-	M	-	-	-	Pectate lyase superfamily protein
MDDHOLLC_01410	0.0	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
MDDHOLLC_01411	2.31e-299	gerKC	-	-	S	ko:K06297	-	ko00000	spore germination
MDDHOLLC_01412	2.27e-249	gerKB	-	-	F	ko:K06296	-	ko00000,ko02000	Spore germination protein
MDDHOLLC_01413	0.0	yxeK	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_01414	3.64e-119	yxeL	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_01415	4.1e-179	yxeM	-	-	M	ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MDDHOLLC_01416	2.11e-148	yxeN	-	-	P	ko:K10009,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MDDHOLLC_01417	3.24e-169	yxeO	-	-	P	ko:K16960,ko:K16963	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_01418	1.97e-276	yxeP	-	-	E	ko:K21613	-	ko00000,ko01000,ko01002	hydrolase activity
MDDHOLLC_01419	5.57e-316	yxeQ	-	-	S	-	-	-	MmgE/PrpD family
MDDHOLLC_01420	3.66e-155	yclH	-	-	P	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
MDDHOLLC_01421	4.76e-307	yclI	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease) YclI
MDDHOLLC_01422	6.16e-145	yclJ	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_01423	0.0	yclK	-	-	T	-	-	-	COG0642 Signal transduction histidine kinase
MDDHOLLC_01424	2.72e-98	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MDDHOLLC_01426	4.58e-316	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MDDHOLLC_01427	1.1e-210	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_01428	1.4e-212	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDDHOLLC_01429	1.61e-175	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_01430	3.24e-222	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4607 ABC-type enterochelin transport system, periplasmic component
MDDHOLLC_01431	9.81e-314	ycnB	-	-	EGP	-	-	-	the major facilitator superfamily
MDDHOLLC_01432	4.99e-194	ycnC	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01433	9.75e-175	-	1.5.1.39	-	C	ko:K10678,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	ko00000,ko00001,ko01000	Nitroreductase family
MDDHOLLC_01434	1.97e-59	ycnE	-	-	S	-	-	-	Monooxygenase
MDDHOLLC_01435	3.92e-70	yczG	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MDDHOLLC_01436	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MDDHOLLC_01437	1.71e-284	gabT	2.6.1.19, 2.6.1.22	-	E	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MDDHOLLC_01438	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MDDHOLLC_01439	8.27e-191	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	Glucose uptake
MDDHOLLC_01440	2.4e-186	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_01441	3.4e-130	ycnI	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01442	0.0	ycnJ	-	-	P	ko:K14166	-	ko00000,ko02000	protein, homolog of Cu resistance protein CopC
MDDHOLLC_01443	4.98e-137	ycnK	-	-	K	ko:K21601	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MDDHOLLC_01444	9.6e-73	-	-	-	-	-	-	-	-
MDDHOLLC_01445	4.82e-174	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
MDDHOLLC_01446	3.83e-125	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
MDDHOLLC_01447	6.83e-94	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
MDDHOLLC_01448	1.84e-260	mtlD	1.1.1.17	-	G	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	COG0246 Mannitol-1-phosphate altronate dehydrogenases
MDDHOLLC_01449	2.89e-87	ycsD	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
MDDHOLLC_01451	2.69e-177	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
MDDHOLLC_01452	7.14e-180	ycsF	-	-	S	ko:K07160	-	ko00000	Belongs to the UPF0271 (lamB) family
MDDHOLLC_01453	7.29e-269	ycsG	-	-	P	-	-	-	COG1914 Mn2 and Fe2 transporters of the NRAMP family
MDDHOLLC_01454	3.29e-190	ycsI	-	-	S	-	-	-	Belongs to the D-glutamate cyclase family
MDDHOLLC_01455	6.36e-173	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
MDDHOLLC_01456	5.97e-241	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
MDDHOLLC_01457	4.65e-167	kipR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01458	4.5e-149	ycsK	-	-	E	-	-	-	anatomical structure formation involved in morphogenesis
MDDHOLLC_01460	1.34e-56	yczJ	-	-	S	-	-	-	biosynthesis
MDDHOLLC_01461	0.0	pbpC	3.4.16.4	-	M	ko:K02545,ko:K21467	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	Penicillin-binding Protein
MDDHOLLC_01462	6.05e-220	ycsN	-	-	S	-	-	-	Oxidoreductase
MDDHOLLC_01463	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	transcriptional regulator, MtlR
MDDHOLLC_01464	0.0	ydaB	-	-	IQ	-	-	-	acyl-CoA ligase
MDDHOLLC_01465	3.01e-204	ydaD	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_01466	3.91e-125	ydaE	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Cupin 2, conserved barrel domain protein
MDDHOLLC_01467	1.16e-148	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MDDHOLLC_01468	3.82e-18	ydaG	-	-	S	-	-	-	general stress protein
MDDHOLLC_01469	1.38e-36	ydaG	-	-	S	-	-	-	general stress protein
MDDHOLLC_01470	7.59e-178	amj	-	-	U	-	-	-	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
MDDHOLLC_01471	6.54e-63	ydzA	-	-	EGP	-	-	-	Domain of unknown function (DUF3817)
MDDHOLLC_01472	3.25e-97	lrpC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
MDDHOLLC_01473	0.0	topB	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MDDHOLLC_01474	1.63e-257	ydaJ	-	-	M	-	-	-	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MDDHOLLC_01475	8.93e-188	ydaK	-	-	T	-	-	-	Diguanylate cyclase, GGDEF domain
MDDHOLLC_01476	0.0	ydaL	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2334)
MDDHOLLC_01477	2.85e-213	ydaM	-	-	M	-	-	-	Glycosyl transferase family group 2
MDDHOLLC_01478	1.39e-59	ydaM	-	-	M	-	-	-	Glycosyl transferase family group 2
MDDHOLLC_01479	0.0	ydaN	-	-	S	-	-	-	Bacterial cellulose synthase subunit
MDDHOLLC_01480	0.0	ydaO	-	-	E	-	-	-	amino acid
MDDHOLLC_01481	6.71e-92	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MDDHOLLC_01482	0.0	ydaP	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
MDDHOLLC_01483	4.55e-55	-	-	-	K	-	-	-	acetyltransferase
MDDHOLLC_01485	1.34e-72	-	-	-	S	-	-	-	Domain of unknown function (DUF4145)
MDDHOLLC_01486	1.93e-32	-	-	-	-	-	-	-	-
MDDHOLLC_01487	7.02e-34	-	-	-	-	-	-	-	-
MDDHOLLC_01488	6.19e-110	yycO	-	-	S	-	-	-	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MDDHOLLC_01489	2.07e-83	-	-	-	-	-	-	-	-
MDDHOLLC_01490	1.42e-268	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
MDDHOLLC_01492	3.14e-18	-	-	-	-	-	-	-	-
MDDHOLLC_01494	6.04e-66	-	-	-	-	-	-	-	-
MDDHOLLC_01495	1.18e-127	-	-	-	-	-	-	-	-
MDDHOLLC_01496	7.18e-52	-	-	-	-	-	-	-	-
MDDHOLLC_01497	5.35e-288	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
MDDHOLLC_01500	1.95e-45	ydaT	-	-	-	-	-	-	-
MDDHOLLC_01501	7.56e-94	yvaD	-	-	S	-	-	-	Family of unknown function (DUF5360)
MDDHOLLC_01502	2.87e-71	yvaE	-	-	P	ko:K03297	-	ko00000,ko02000	Small Multidrug Resistance protein
MDDHOLLC_01503	2.19e-181	ydbA	-	-	P	-	-	-	EcsC protein family
MDDHOLLC_01504	2.34e-10	gsiB	-	-	S	ko:K06884	-	ko00000	general stress protein
MDDHOLLC_01505	6.01e-75	ydbB	-	-	G	-	-	-	Cupin domain
MDDHOLLC_01506	2.39e-78	ydbC	-	-	S	-	-	-	Domain of unknown function (DUF4937
MDDHOLLC_01507	7.8e-198	ydbD	-	-	P	ko:K07217	-	ko00000	Catalase
MDDHOLLC_01508	3.82e-255	dctB	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
MDDHOLLC_01509	0.0	dctS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MDDHOLLC_01510	3.67e-153	dctR	-	-	T	ko:K02475,ko:K11692	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
MDDHOLLC_01511	3.91e-287	dctA	-	-	U	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MDDHOLLC_01512	1.22e-230	ydbI	-	-	S	-	-	-	AI-2E family transporter
MDDHOLLC_01513	3.23e-219	ydbJ	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_01514	9.93e-167	ydbK	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MDDHOLLC_01515	5.88e-46	ydbL	-	-	-	-	-	-	-
MDDHOLLC_01516	2.98e-260	ydbM	-	-	I	-	-	-	acyl-CoA dehydrogenase
MDDHOLLC_01517	1.13e-15	-	-	-	S	-	-	-	Fur-regulated basic protein B
MDDHOLLC_01518	6.58e-14	-	-	-	S	-	-	-	Fur-regulated basic protein A
MDDHOLLC_01519	1.64e-159	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDDHOLLC_01520	4.76e-72	ydbP	-	-	CO	-	-	-	Thioredoxin
MDDHOLLC_01521	2.16e-258	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
MDDHOLLC_01522	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MDDHOLLC_01523	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MDDHOLLC_01524	2.18e-96	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
MDDHOLLC_01525	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Membrane
MDDHOLLC_01526	2.08e-138	ydcA	-	-	S	-	-	-	membrane protein (homolog of Drosophila rhomboid)
MDDHOLLC_01527	4.42e-75	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MDDHOLLC_01528	6.39e-235	ydcC	-	-	M	-	-	-	COG2834 Outer membrane lipoprotein-sorting protein
MDDHOLLC_01529	2.31e-278	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MDDHOLLC_01530	6.68e-57	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
MDDHOLLC_01531	4.34e-75	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
MDDHOLLC_01532	1.05e-186	rsbR	-	-	T	ko:K17763	-	ko00000,ko03021	Positive regulator of sigma-B
MDDHOLLC_01533	1.09e-75	rsbS	-	-	T	ko:K17762	-	ko00000,ko03021	antagonist
MDDHOLLC_01534	1.73e-89	rsbT	2.7.11.1	-	T	ko:K17752	-	ko00000,ko01000,ko01001,ko03021	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
MDDHOLLC_01535	8.83e-242	rsbU	3.1.3.3	-	KT	ko:K07315	-	ko00000,ko01000,ko03021	phosphatase
MDDHOLLC_01536	9.77e-71	rsbV	-	-	T	ko:K04749	-	ko00000,ko03021	Belongs to the anti-sigma-factor antagonist family
MDDHOLLC_01537	5.84e-110	rsbW	2.7.11.1	-	F	ko:K04757	-	ko00000,ko01000,ko01001,ko03021	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
MDDHOLLC_01538	1.14e-180	sigB	-	-	K	ko:K03090	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_01539	2.74e-139	rsbX	3.1.3.3	-	KT	ko:K05518	-	ko00000,ko01000,ko03021	Sigma factor PP2C-like phosphatases
MDDHOLLC_01540	0.0	tex	-	-	K	ko:K06959	-	ko00000	COG2183 Transcriptional accessory protein
MDDHOLLC_01541	1.78e-21	-	-	-	-	-	-	-	-
MDDHOLLC_01542	7.69e-73	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
MDDHOLLC_01550	7.8e-124	yrkL	-	-	S	ko:K11748	-	ko00000,ko02000	Flavodoxin-like fold
MDDHOLLC_01551	5.38e-192	-	-	-	S	-	-	-	Serine aminopeptidase, S33
MDDHOLLC_01552	0.0	-	-	-	EGP	ko:K03761,ko:K03762	-	ko00000,ko02000	Transporter
MDDHOLLC_01553	3.71e-82	-	-	-	I	ko:K01066	-	ko00000,ko01000	Esterase
MDDHOLLC_01554	2.1e-26	-	-	-	I	-	-	-	Alpha beta hydrolase fold
MDDHOLLC_01555	2.29e-60	ohrB	-	-	O	-	-	-	OsmC-like protein
MDDHOLLC_01556	1.57e-64	ohrR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01557	1.86e-93	ywnA	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01558	7.44e-143	ywnB	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
MDDHOLLC_01559	3.87e-42	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock
MDDHOLLC_01560	2.63e-53	yrkD	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01561	1.38e-108	yrkE	-	-	O	-	-	-	DsrE/DsrF/DrsH-like family
MDDHOLLC_01562	9.11e-24	-	-	-	P	-	-	-	Rhodanese Homology Domain
MDDHOLLC_01563	4.42e-130	yrkF	-	-	OP	-	-	-	Belongs to the sulfur carrier protein TusA family
MDDHOLLC_01564	1.23e-255	yrkH	-	-	P	-	-	-	Rhodanese Homology Domain
MDDHOLLC_01565	6.46e-49	yrkI	-	-	O	-	-	-	Belongs to the sulfur carrier protein TusA family
MDDHOLLC_01566	2.07e-165	yrkJ	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MDDHOLLC_01567	1.27e-150	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
MDDHOLLC_01568	1.73e-87	-	-	-	S	-	-	-	Protein of unknown function (DUF2812)
MDDHOLLC_01569	7.89e-66	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
MDDHOLLC_01570	2.92e-231	-	-	-	S	-	-	-	Patatin-like phospholipase
MDDHOLLC_01571	5.43e-109	-	-	-	S	-	-	-	DinB superfamily
MDDHOLLC_01572	1.58e-144	dpaL	4.3.1.15	-	E	ko:K01751	-	ko00000,ko01000	Pyridoxal-phosphate dependent enzyme
MDDHOLLC_01573	6.58e-86	-	-	-	K	-	-	-	COG1802 Transcriptional regulators
MDDHOLLC_01574	4.46e-52	-	-	-	J	-	-	-	Endoribonuclease L-PSP
MDDHOLLC_01575	6.52e-176	-	-	-	E	ko:K03837	-	ko00000,ko02000	Serine transporter
MDDHOLLC_01576	2.64e-78	-	-	-	E	-	-	-	Peptidase dimerisation domain
MDDHOLLC_01577	2.43e-65	-	-	-	E	-	-	-	Peptidase dimerisation domain
MDDHOLLC_01578	5.7e-161	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
MDDHOLLC_01579	1.34e-219	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MDDHOLLC_01580	1.18e-294	-	-	-	K	-	-	-	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MDDHOLLC_01581	3.08e-242	ydeG	-	-	EGP	-	-	-	Major facilitator superfamily
MDDHOLLC_01582	4.68e-38	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MDDHOLLC_01585	0.0	yvdP	-	-	C	-	-	-	COG0277 FAD FMN-containing dehydrogenases
MDDHOLLC_01586	9.72e-14	-	-	-	E	ko:K07032	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_01587	6.49e-217	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	COG1230 Co Zn Cd efflux system component
MDDHOLLC_01588	1.26e-246	trkA	-	-	P	ko:K07222	-	ko00000	Oxidoreductase
MDDHOLLC_01589	5.47e-130	yrkC	-	-	G	-	-	-	Cupin domain
MDDHOLLC_01590	5.65e-67	ydeH	-	-	-	-	-	-	-
MDDHOLLC_01591	8.41e-212	-	-	-	S	-	-	-	Sodium Bile acid symporter family
MDDHOLLC_01592	2.9e-254	adhA	-	-	C	ko:K13979	-	ko00000,ko01000	alcohol dehydrogenase
MDDHOLLC_01593	2.44e-85	adhR	-	-	K	ko:K21745	-	ko00000,ko03000	helix_turn_helix, mercury resistance
MDDHOLLC_01594	4.37e-285	nhaC_1	-	-	C	-	-	-	antiporter
MDDHOLLC_01595	0.0	-	-	-	K	ko:K00375	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
MDDHOLLC_01596	8.46e-146	paiB	-	-	K	ko:K07734	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_01598	4.16e-248	ydeR	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
MDDHOLLC_01599	4.7e-130	ydeS	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01600	3.45e-64	yraD	-	-	M	ko:K06439	-	ko00000	Spore coat protein
MDDHOLLC_01601	2.4e-33	yraE	-	-	-	ko:K06440	-	ko00000	-
MDDHOLLC_01602	3.98e-278	adhB	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MDDHOLLC_01603	4.76e-84	yraF	-	-	M	-	-	-	Spore coat protein
MDDHOLLC_01604	9.9e-49	yraG	-	-	-	ko:K06440	-	ko00000	-
MDDHOLLC_01605	2.33e-273	ydfH	2.7.13.3	-	T	ko:K11623	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_01606	3.82e-140	ydfI	-	-	K	ko:K11624	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_01607	0.0	ydfJ	-	-	S	ko:K06994,ko:K11625	ko02020,map02020	ko00000,ko00001	drug exporters of the RND superfamily
MDDHOLLC_01608	3.27e-169	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
MDDHOLLC_01609	2.2e-97	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
MDDHOLLC_01610	4.21e-254	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
MDDHOLLC_01611	3.57e-125	ynaD	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_01612	6.07e-192	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_01613	6.59e-249	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
MDDHOLLC_01614	1.36e-268	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
MDDHOLLC_01615	3.22e-287	fabF_1	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MDDHOLLC_01616	1.06e-198	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MDDHOLLC_01617	2.47e-155	ydhB	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MDDHOLLC_01618	7.23e-107	bltD	2.3.1.57	-	K	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	FR47-like protein
MDDHOLLC_01619	7.18e-194	bltR	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MDDHOLLC_01620	5.97e-57	gmT1	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MDDHOLLC_01621	1.14e-115	gmT1	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MDDHOLLC_01622	6.44e-145	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
MDDHOLLC_01623	3.23e-121	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
MDDHOLLC_01624	3.28e-201	ycsA	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Tartrate dehydrogenase
MDDHOLLC_01625	7.66e-153	ydhC	-	-	K	-	-	-	FCD
MDDHOLLC_01626	2.65e-288	ydhE	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MDDHOLLC_01629	0.0	pbpE	-	-	V	-	-	-	Beta-lactamase
MDDHOLLC_01631	6.11e-128	ydhK	-	-	M	-	-	-	Protein of unknown function (DUF1541)
MDDHOLLC_01632	2.24e-247	ydhL	-	-	EGP	ko:K18567	-	ko00000,ko02000	COG2814 Arabinose efflux permease
MDDHOLLC_01633	2.4e-170	ydhQ	-	-	K	ko:K03492	-	ko00000,ko03000	UTRA
MDDHOLLC_01634	1.09e-152	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
MDDHOLLC_01635	2.04e-275	yycB1	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
MDDHOLLC_01636	4.25e-65	yvdR	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
MDDHOLLC_01637	4.48e-67	yvdS	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MDDHOLLC_01638	9.98e-134	yvdT_1	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01639	0.0	ybeC	-	-	E	-	-	-	amino acid
MDDHOLLC_01640	2.86e-210	ydhU	-	-	P	ko:K07217	-	ko00000	Catalase
MDDHOLLC_01641	2.7e-110	yndB	-	-	S	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
MDDHOLLC_01642	3.16e-234	yhfP	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Quinone oxidoreductase
MDDHOLLC_01643	0.0	iolT	-	-	U	ko:K02100,ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MDDHOLLC_01646	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01649	7.21e-236	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MDDHOLLC_01650	7.42e-112	ydiB	-	-	S	ko:K06925	-	ko00000,ko03016	ATPase or kinase
MDDHOLLC_01651	1.02e-162	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214 Inactive homolog of metal-dependent proteases
MDDHOLLC_01652	1.41e-108	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MDDHOLLC_01653	5.11e-242	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MDDHOLLC_01654	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
MDDHOLLC_01655	2.95e-117	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MDDHOLLC_01656	1.29e-149	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MDDHOLLC_01657	1.72e-29	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MDDHOLLC_01658	3.33e-162	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MDDHOLLC_01659	1.11e-37	ydiK	-	-	S	-	-	-	Domain of unknown function (DUF4305)
MDDHOLLC_01660	8.26e-165	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
MDDHOLLC_01662	3.45e-29	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MDDHOLLC_01663	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MDDHOLLC_01664	5.53e-86	-	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
MDDHOLLC_01665	2.09e-33	-	-	-	S	-	-	-	Lantibiotic dehydratase, C terminus
MDDHOLLC_01666	4.06e-10	-	-	-	C	-	-	-	Nitroreductase
MDDHOLLC_01668	8.29e-118	-	-	-	S	ko:K09136	-	ko00000,ko03009	YcaO cyclodehydratase, ATP-ad Mg2+-binding
MDDHOLLC_01669	1.57e-45	cobT	1.13.11.79, 2.4.2.21	-	C	ko:K00768,ko:K04719	ko00740,ko00860,ko01100,map00740,map00860,map01100	ko00000,ko00001,ko00002,ko01000	coenzyme F420-1:gamma-L-glutamate ligase activity
MDDHOLLC_01670	1.13e-30	-	-	-	C	-	-	-	Lantibiotic biosynthesis dehydratase C-term
MDDHOLLC_01672	2.16e-98	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
MDDHOLLC_01673	9.19e-41	XK27_09830	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transporter
MDDHOLLC_01674	0.0	gutR	-	-	K	ko:K16247	-	ko00000,ko03000	NB-ARC domain
MDDHOLLC_01675	2.47e-13	gutR	-	-	K	ko:K16247	-	ko00000,ko03000	NB-ARC domain
MDDHOLLC_01676	4.83e-255	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
MDDHOLLC_01677	1.4e-314	gutP	-	-	G	ko:K03292,ko:K16248	-	ko00000,ko02000	MFS/sugar transport protein
MDDHOLLC_01678	1.42e-219	ydjE	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
MDDHOLLC_01679	1.47e-40	yjdJ	-	-	S	-	-	-	Domain of unknown function (DUF4306)
MDDHOLLC_01680	3.2e-145	pspA	-	-	KT	ko:K03969	-	ko00000	Phage shock protein A
MDDHOLLC_01681	1.55e-229	ydjG	-	-	L	-	-	-	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MDDHOLLC_01682	3.05e-160	ydjH	-	-	S	ko:K06872	-	ko00000	COG1512 Beta-propeller domains of methanol dehydrogenase type
MDDHOLLC_01683	6.89e-202	ydjI	-	-	S	-	-	-	virion core protein (lumpy skin disease virus)
MDDHOLLC_01684	0.0	oatA	-	-	I	-	-	-	Acyltransferase family
MDDHOLLC_01685	4.82e-194	rsiV	-	-	S	-	-	-	Protein of unknown function (DUF3298)
MDDHOLLC_01686	8.77e-51	sigV	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01687	7.67e-49	sigV	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01688	8.25e-248	ydjL	1.1.1.264, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00098	ko00650,map00650	ko00000,ko00001,ko01000	Dehydrogenase
MDDHOLLC_01689	6.51e-82	ydjM	-	-	M	-	-	-	Lytic transglycolase
MDDHOLLC_01690	2.18e-54	ydjN	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
MDDHOLLC_01691	2.16e-130	ydjN	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
MDDHOLLC_01694	0.0	cotA	1.16.3.3	-	Q	ko:K06324	-	ko00000,ko01000	multicopper oxidases
MDDHOLLC_01695	1.97e-269	gabP	-	-	E	ko:K11735	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_01696	1.42e-30	gabP	-	-	E	ko:K11735	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_01697	7.99e-226	yeaC	-	-	S	ko:K03924	-	ko00000,ko01000	COG0714 MoxR-like ATPases
MDDHOLLC_01698	6.18e-266	yeaD	-	-	S	-	-	-	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
MDDHOLLC_01699	0.0	yebA	-	-	E	-	-	-	COG1305 Transglutaminase-like enzymes
MDDHOLLC_01700	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
MDDHOLLC_01701	9.42e-122	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_01702	4.32e-313	-	-	-	S	-	-	-	Domain of unknown function (DUF4179)
MDDHOLLC_01703	1.75e-269	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
MDDHOLLC_01704	6.19e-168	yebC	-	-	M	-	-	-	Membrane
MDDHOLLC_01705	1.21e-118	yebE	-	-	S	-	-	-	UPF0316 protein
MDDHOLLC_01706	6.56e-40	yebG	-	-	S	-	-	-	NETI protein
MDDHOLLC_01707	3.78e-107	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MDDHOLLC_01708	3.74e-286	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MDDHOLLC_01709	6.38e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MDDHOLLC_01710	5.22e-166	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
MDDHOLLC_01711	3.79e-52	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MDDHOLLC_01712	1.34e-166	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MDDHOLLC_01713	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MDDHOLLC_01714	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MDDHOLLC_01715	1.46e-241	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
MDDHOLLC_01716	9.96e-135	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MDDHOLLC_01717	6.91e-103	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
MDDHOLLC_01718	3.48e-159	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
MDDHOLLC_01719	2.32e-297	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
MDDHOLLC_01720	1.2e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF2892)
MDDHOLLC_01721	2.13e-284	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
MDDHOLLC_01722	1.01e-124	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
MDDHOLLC_01723	2.51e-85	yerB	-	-	S	-	-	-	Protein of unknown function (DUF3048) C-terminal domain
MDDHOLLC_01724	2.09e-136	yerB	-	-	S	-	-	-	Protein of unknown function (DUF3048) C-terminal domain
MDDHOLLC_01725	2.03e-67	yerC	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01726	0.0	yerD	1.4.7.1	-	E	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	ko00000,ko00001,ko01000	Belongs to the glutamate synthase family
MDDHOLLC_01727	8.71e-164	pcrB	-	-	I	ko:K07094	-	ko00000,ko01000	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MDDHOLLC_01728	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
MDDHOLLC_01729	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MDDHOLLC_01730	6.46e-285	camS	-	-	S	-	-	-	COG4851 Protein involved in sex pheromone biosynthesis
MDDHOLLC_01731	3.28e-191	yerI	-	-	S	-	-	-	homoserine kinase type II (protein kinase fold)
MDDHOLLC_01732	5.32e-41	yerI	-	-	S	-	-	-	homoserine kinase type II (protein kinase fold)
MDDHOLLC_01733	2.38e-157	sapB	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
MDDHOLLC_01734	0.0	putP	-	-	E	ko:K03307,ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MDDHOLLC_01735	1.81e-60	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MDDHOLLC_01736	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MDDHOLLC_01737	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MDDHOLLC_01738	1.23e-194	yerO	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_01739	0.0	swrC	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MDDHOLLC_01740	5.16e-218	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MDDHOLLC_01741	0.0	rlmCD	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDDHOLLC_01742	5.4e-28	-	-	-	-	-	-	-	-
MDDHOLLC_01743	9.62e-203	cylA	-	-	V	ko:K01990,ko:K09695,ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
MDDHOLLC_01744	3.36e-176	cylB	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
MDDHOLLC_01745	3.7e-70	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MDDHOLLC_01746	5.18e-60	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MDDHOLLC_01747	8.51e-72	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MDDHOLLC_01748	5.95e-101	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MDDHOLLC_01749	1.31e-73	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MDDHOLLC_01750	0.0	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	nucleic acid phosphodiester bond hydrolysis
MDDHOLLC_01751	3.12e-162	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
MDDHOLLC_01753	1.32e-136	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
MDDHOLLC_01754	2.67e-60	cotJA	-	-	S	ko:K06332	-	ko00000	Spore coat associated protein JA (CotJA)
MDDHOLLC_01755	9.4e-61	cotJB	-	-	S	ko:K06333	-	ko00000	CotJB protein
MDDHOLLC_01756	1.48e-133	cotJC	-	-	P	ko:K06334	-	ko00000	Spore Coat
MDDHOLLC_01757	6.63e-122	yesJ	-	-	K	-	-	-	Acetyltransferase (GNAT) family
MDDHOLLC_01758	0.000118	-	-	-	-	-	-	-	-
MDDHOLLC_01759	8.62e-155	yetF	-	-	S	-	-	-	membrane
MDDHOLLC_01760	1.11e-72	yetG	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
MDDHOLLC_01761	8.11e-57	yetH	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_01762	1.29e-11	yetH	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_01763	1.04e-195	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MDDHOLLC_01764	1.34e-31	-	-	-	S	-	-	-	Uncharacterized small protein (DUF2292)
MDDHOLLC_01765	3.68e-73	-	-	-	H	-	-	-	riboflavin kinase activity
MDDHOLLC_01766	4.74e-133	yetJ	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
MDDHOLLC_01768	1.92e-113	yetL	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_01769	6.44e-260	yetM	-	-	CH	-	-	-	FAD binding domain
MDDHOLLC_01770	2.38e-252	yetN	-	-	S	-	-	-	Protein of unknown function (DUF3900)
MDDHOLLC_01771	0.0	cypD	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
MDDHOLLC_01773	5.83e-67	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MDDHOLLC_01774	5.72e-207	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MDDHOLLC_01775	7.58e-162	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MDDHOLLC_01776	4.52e-100	-	-	-	S	-	-	-	protein homooligomerization
MDDHOLLC_01777	5.22e-163	-	-	-	-	-	-	-	-
MDDHOLLC_01778	2.06e-233	-	-	-	S	-	-	-	ATP diphosphatase activity
MDDHOLLC_01779	0.0	-	-	-	S	ko:K09136	-	ko00000,ko03009	YcaO cyclodehydratase, ATP-ad Mg2+-binding
MDDHOLLC_01780	1.29e-194	-	-	-	C	-	-	-	Nitroreductase family
MDDHOLLC_01781	1.68e-146	-	-	-	S	-	-	-	CAAX protease self-immunity
MDDHOLLC_01782	2.23e-181	-	2.1.1.163, 2.1.1.201	-	Q	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	methyltransferase
MDDHOLLC_01783	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
MDDHOLLC_01784	1.88e-122	yfnH	2.7.7.33	-	JM	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	ko00000,ko00001,ko01000	Nucleotidyl transferase
MDDHOLLC_01785	7.9e-32	yfnH	2.7.7.33	-	JM	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	ko00000,ko00001,ko01000	Nucleotidyl transferase
MDDHOLLC_01786	3.93e-219	yfnG	4.2.1.45, 4.2.1.46	-	M	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	dehydratase
MDDHOLLC_01787	6.61e-230	yfnF	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
MDDHOLLC_01788	4.01e-282	yfnE	-	-	S	-	-	-	Glycosyltransferase like family 2
MDDHOLLC_01789	2.56e-177	yfnD	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
MDDHOLLC_01790	1.18e-24	yfnD	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
MDDHOLLC_01791	6.35e-277	fsr	-	-	P	ko:K08223	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_01792	2.4e-312	yfnA	-	-	E	ko:K03294	-	ko00000	amino acid
MDDHOLLC_01793	0.0	yfmT	1.2.1.3, 1.2.1.67	-	C	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MDDHOLLC_01794	2.04e-162	yfmS	-	-	NT	-	-	-	chemotaxis protein
MDDHOLLC_01795	1.21e-214	yhxD	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MDDHOLLC_01796	3.45e-265	-	-	-	M	-	-	-	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_01797	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MDDHOLLC_01798	8.7e-91	yfmP	-	-	K	ko:K21902	-	ko00000,ko03000	transcriptional
MDDHOLLC_01799	3.43e-262	yfmO	-	-	EGP	ko:K08221	-	ko00000,ko02000	Major facilitator superfamily
MDDHOLLC_01800	0.0	yheS_1	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MDDHOLLC_01801	2.83e-261	yfmL	-	-	L	-	-	-	COG0513 Superfamily II DNA and RNA helicases
MDDHOLLC_01802	1.86e-55	yfmK	2.3.1.128	-	K	ko:K03790	-	ko00000,ko01000,ko03009	acetyltransferase
MDDHOLLC_01803	3.87e-238	yfmJ	-	-	S	ko:K07119	-	ko00000	N-terminal domain of oxidoreductase
MDDHOLLC_01804	2.1e-31	-	-	-	S	-	-	-	Protein of unknown function (DUF3212)
MDDHOLLC_01805	4.9e-76	yflT	-	-	S	-	-	-	Heat induced stress protein YflT
MDDHOLLC_01806	1.53e-306	pel	4.2.2.2	-	G	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectate lyase
MDDHOLLC_01807	0.0	yflS	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
MDDHOLLC_01811	2.39e-08	-	-	-	S	-	-	-	domain, Protein
MDDHOLLC_01813	0.0	ywpD	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_01814	5.23e-154	ywpD	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_01815	8.29e-192	M1-574	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
MDDHOLLC_01816	0.0	-	-	-	M	-	-	-	cell wall anchor domain
MDDHOLLC_01817	2.25e-103	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
MDDHOLLC_01818	0.0	citS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MDDHOLLC_01819	9.33e-153	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
MDDHOLLC_01820	2.82e-202	yflP	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
MDDHOLLC_01821	5.52e-285	citM	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
MDDHOLLC_01822	1.34e-189	yflN	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MDDHOLLC_01823	3.37e-276	nos	1.14.14.47	-	C	ko:K00491	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MDDHOLLC_01824	3.93e-59	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
MDDHOLLC_01825	4.17e-157	yflK	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_01826	5.84e-21	yflJ	-	-	S	-	-	-	Protein of unknown function (DUF2639)
MDDHOLLC_01827	1.98e-26	yflI	-	-	-	-	-	-	-
MDDHOLLC_01828	1.67e-66	yflH	-	-	S	-	-	-	Protein of unknown function (DUF3243)
MDDHOLLC_01829	1.9e-177	yflG	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
MDDHOLLC_01830	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
MDDHOLLC_01831	4.37e-65	yfmQ	-	-	S	-	-	-	Uncharacterised protein from bacillus cereus group
MDDHOLLC_01832	1.89e-17	yfmQ	-	-	S	-	-	-	Uncharacterised protein from bacillus cereus group
MDDHOLLC_01833	0.0	yflE	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
MDDHOLLC_01834	4.03e-82	ydhN1	-	-	S	-	-	-	Domain of unknown function (DUF1992)
MDDHOLLC_01835	5.74e-76	cotP	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MDDHOLLC_01836	8.17e-52	ydgA	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
MDDHOLLC_01837	1.85e-53	ydgB	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
MDDHOLLC_01838	1.1e-313	treP	2.7.1.201	-	G	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_01839	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
MDDHOLLC_01840	3.14e-166	treR	-	-	K	ko:K03486	-	ko00000,ko03000	transcriptional
MDDHOLLC_01841	1.45e-158	frp	-	-	C	-	-	-	nitroreductase
MDDHOLLC_01842	6.08e-108	yibF	-	-	S	-	-	-	YibE/F-like protein
MDDHOLLC_01843	1.47e-32	yibF	-	-	S	-	-	-	YibE/F-like protein
MDDHOLLC_01844	1.42e-251	yibE	-	-	S	-	-	-	YibE/F-like protein
MDDHOLLC_01845	0.0	cpdB	3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45	-	F	ko:K01081,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
MDDHOLLC_01846	0.0	cpdB	3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45	-	F	ko:K01081,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
MDDHOLLC_01847	7.82e-118	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
MDDHOLLC_01848	1.51e-237	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MDDHOLLC_01849	9.99e-216	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MDDHOLLC_01850	4.11e-174	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
MDDHOLLC_01851	1.57e-248	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_01852	1.47e-41	yfkK	-	-	S	-	-	-	Belongs to the UPF0435 family
MDDHOLLC_01853	6.88e-112	yfkJ	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MDDHOLLC_01854	1.51e-69	yfkI	-	-	S	-	-	-	gas vesicle protein
MDDHOLLC_01855	1.6e-184	yihY	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
MDDHOLLC_01856	6.71e-12	-	-	-	-	-	-	-	-
MDDHOLLC_01857	5.89e-278	yfkF	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_01858	1.7e-238	cax	-	-	P	ko:K07300	-	ko00000,ko02000	COG0387 Ca2 H antiporter
MDDHOLLC_01859	1.33e-184	yfkD	-	-	S	-	-	-	YfkD-like protein
MDDHOLLC_01860	2.37e-185	yfkC	-	-	M	-	-	-	Mechanosensitive ion channel
MDDHOLLC_01861	2.69e-278	yfkA	-	-	S	-	-	-	YfkB-like domain
MDDHOLLC_01862	7.99e-37	yfjT	-	-	-	-	-	-	-
MDDHOLLC_01863	4.36e-199	pdaA	-	-	G	ko:K01567	-	ko00000,ko01000	deacetylase
MDDHOLLC_01864	2.98e-188	yfjR	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MDDHOLLC_01866	2.61e-235	corA	-	-	P	ko:K03284	-	ko00000,ko02000	Mediates influx of magnesium ions
MDDHOLLC_01867	1.21e-208	yfjP	3.2.2.21	-	L	ko:K01247	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MDDHOLLC_01868	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDDHOLLC_01869	3.41e-58	-	-	-	S	-	-	-	YfzA-like protein
MDDHOLLC_01870	4.22e-245	yfjN	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MDDHOLLC_01871	1.76e-112	yfjM	-	-	S	-	-	-	Psort location Cytoplasmic, score
MDDHOLLC_01872	3.65e-206	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MDDHOLLC_01873	5.1e-240	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MDDHOLLC_01874	2.67e-272	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MDDHOLLC_01875	0.0	acoL	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MDDHOLLC_01876	0.0	acoR	-	-	KQ	ko:K21405	-	ko00000,ko03000	COG3284 Transcriptional activator of acetoin glycerol metabolism
MDDHOLLC_01877	6.64e-22	sspH	-	-	S	ko:K06425	-	ko00000	Belongs to the SspH family
MDDHOLLC_01878	1.67e-289	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MDDHOLLC_01879	7.72e-179	glvR	-	-	F	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
MDDHOLLC_01880	0.0	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_01881	0.0	yfiB3	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MDDHOLLC_01882	0.0	yfiC3	-	-	V	ko:K06147	-	ko00000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MDDHOLLC_01883	3.2e-81	yfiD3	-	-	S	-	-	-	DoxX
MDDHOLLC_01884	7.82e-204	yfiE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
MDDHOLLC_01885	1.57e-209	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MDDHOLLC_01886	4.62e-125	padR	-	-	K	-	-	-	transcriptional
MDDHOLLC_01887	3.47e-142	-	1.6.5.2	-	S	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
MDDHOLLC_01888	6.13e-114	yfiQ	-	-	G	ko:K21462	-	ko00000	COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MDDHOLLC_01889	1.39e-68	yfiQ	-	-	G	ko:K21462	-	ko00000	COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MDDHOLLC_01890	6.48e-258	-	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
MDDHOLLC_01891	8.2e-298	-	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
MDDHOLLC_01892	1.66e-60	yrdF	-	-	K	ko:K03623	-	ko00000	ribonuclease inhibitor
MDDHOLLC_01893	1.05e-124	yfiT	-	-	S	-	-	-	Belongs to the metal hydrolase YfiT family
MDDHOLLC_01894	2.04e-104	yfiU	-	-	EGP	-	-	-	the major facilitator superfamily
MDDHOLLC_01895	5.24e-232	yfiU	-	-	EGP	-	-	-	the major facilitator superfamily
MDDHOLLC_01896	2.29e-107	yfiV	-	-	K	-	-	-	transcriptional
MDDHOLLC_01897	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MDDHOLLC_01898	1.57e-203	yfhB	-	-	S	-	-	-	PhzF family
MDDHOLLC_01899	5.58e-40	yfhC	-	-	C	-	-	-	nitroreductase
MDDHOLLC_01900	3.53e-69	yfhC	-	-	C	-	-	-	nitroreductase
MDDHOLLC_01901	3.61e-34	yfhD	-	-	S	-	-	-	YfhD-like protein
MDDHOLLC_01903	8.19e-213	yfhF	-	-	S	ko:K07071	-	ko00000	nucleoside-diphosphate sugar epimerase
MDDHOLLC_01904	5.21e-182	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
MDDHOLLC_01905	3.1e-69	yfhH	-	-	S	-	-	-	Protein of unknown function (DUF1811)
MDDHOLLC_01906	2.25e-265	yfhI	-	-	EGP	-	-	-	-transporter
MDDHOLLC_01908	2.02e-215	mpr	-	-	M	-	-	-	Belongs to the peptidase S1B family
MDDHOLLC_01909	5.56e-21	yfhJ	-	-	S	-	-	-	WVELL protein
MDDHOLLC_01910	4.89e-21	yfhJ	-	-	S	-	-	-	WVELL protein
MDDHOLLC_01911	1.91e-120	yfhK	-	-	T	-	-	-	Bacterial SH3 domain homologues
MDDHOLLC_01912	6.03e-57	yfhL	-	-	S	-	-	-	SdpI/YhfL protein family
MDDHOLLC_01913	2.28e-217	-	-	-	S	-	-	-	Alpha/beta hydrolase family
MDDHOLLC_01914	1.26e-167	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_01915	1.28e-55	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_01916	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
MDDHOLLC_01917	2.94e-236	yfhP	-	-	S	ko:K07038	-	ko00000	membrane-bound metal-dependent
MDDHOLLC_01918	1.64e-261	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific
MDDHOLLC_01919	1.47e-49	yfhS	-	-	-	-	-	-	-
MDDHOLLC_01920	3.81e-173	fabL	1.3.1.104	-	IQ	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_01921	4.77e-06	sspE	-	-	S	ko:K06422	-	ko00000	Small, acid-soluble spore protein, gamma-type
MDDHOLLC_01922	1.4e-49	ygaB	-	-	S	-	-	-	YgaB-like protein
MDDHOLLC_01923	2.32e-135	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
MDDHOLLC_01924	0.0	ygaD	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
MDDHOLLC_01925	2.08e-234	ygaE	-	-	S	-	-	-	Membrane
MDDHOLLC_01926	5.16e-72	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MDDHOLLC_01927	1.02e-191	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MDDHOLLC_01928	1.39e-111	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Peroxiredoxin
MDDHOLLC_01929	2.37e-104	perR	-	-	P	ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
MDDHOLLC_01930	5.22e-28	ygzB	-	-	S	-	-	-	UPF0295 protein
MDDHOLLC_01931	2.68e-27	ygzB	-	-	S	-	-	-	UPF0295 protein
MDDHOLLC_01932	1.59e-212	ygxA	-	-	S	-	-	-	Nucleotidyltransferase-like
MDDHOLLC_01933	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MDDHOLLC_01950	1.91e-24	-	-	-	C	-	-	-	Na+/H+ antiporter family
MDDHOLLC_01951	5.75e-168	ygaJ	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
MDDHOLLC_01952	0.0	thiC	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MDDHOLLC_01953	0.0	ygaK	-	-	C	-	-	-	Berberine and berberine like
MDDHOLLC_01955	4.62e-148	oppA5	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 5
MDDHOLLC_01956	2.12e-123	oppA5	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 5
MDDHOLLC_01957	6.19e-123	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MDDHOLLC_01958	2.52e-161	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_01959	3.3e-208	-	-	-	P	ko:K02031,ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
MDDHOLLC_01960	0.0	katA	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MDDHOLLC_01961	6.12e-230	-	-	-	S	ko:K07045	-	ko00000	Amidohydrolase
MDDHOLLC_01962	6.12e-178	ssuB	-	-	P	ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
MDDHOLLC_01963	3.53e-229	ssuA	-	-	M	ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Sulfonate ABC transporter
MDDHOLLC_01964	5.58e-184	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MDDHOLLC_01965	2.06e-90	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
MDDHOLLC_01966	2.77e-163	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
MDDHOLLC_01967	3.39e-55	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MDDHOLLC_01968	9.07e-107	ygaO	-	-	-	-	-	-	-
MDDHOLLC_01969	9.41e-32	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_01971	9.43e-139	yhzB	-	-	S	-	-	-	B3/4 domain
MDDHOLLC_01972	1.64e-284	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MDDHOLLC_01973	3.87e-221	yhbB	-	-	S	-	-	-	Putative amidase domain
MDDHOLLC_01974	4.84e-112	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MDDHOLLC_01975	2.8e-140	yhbD	-	-	K	-	-	-	Protein of unknown function (DUF4004)
MDDHOLLC_01976	1.98e-85	yhbE	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
MDDHOLLC_01977	3.13e-91	yhbF	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
MDDHOLLC_01978	1.23e-07	-	-	-	-	-	-	-	-
MDDHOLLC_01979	0.0	prkA	-	-	T	ko:K07180	-	ko00000	Ser protein kinase
MDDHOLLC_01980	5.45e-279	yhbH	-	-	S	ko:K09786	-	ko00000	Belongs to the UPF0229 family
MDDHOLLC_01981	4.15e-98	yhbI	-	-	K	ko:K15973	-	ko00000,ko03000	DNA-binding transcription factor activity
MDDHOLLC_01982	1.54e-132	yhbJ	-	-	V	-	-	-	COG1566 Multidrug resistance efflux pump
MDDHOLLC_01983	0.0	yhcA	-	-	EGP	ko:K03446	-	ko00000,ko00002,ko02000	the major facilitator superfamily
MDDHOLLC_01984	9.09e-129	wrbA	1.6.5.2	-	S	ko:K03809	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
MDDHOLLC_01985	1.41e-72	yhcC	-	-	-	-	-	-	-
MDDHOLLC_01986	5.32e-65	-	-	-	-	-	-	-	-
MDDHOLLC_01987	1.35e-80	yhcF	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_01988	1.4e-159	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_01989	9.59e-215	yhcH	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_01990	1.57e-209	yhcI	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MDDHOLLC_01991	7.28e-42	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
MDDHOLLC_01992	6.29e-185	metQ_3	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
MDDHOLLC_01993	1.43e-234	yhcK	2.7.7.65	-	T	ko:K18967	-	ko00000,ko01000,ko02000	COG2199 FOG GGDEF domain
MDDHOLLC_01994	1.66e-304	tcyP	-	-	U	ko:K06956	-	ko00000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MDDHOLLC_01995	2.79e-77	yhcM	-	-	-	-	-	-	-
MDDHOLLC_01996	2.69e-122	yhcN	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MDDHOLLC_01997	6.11e-79	yhcP	-	-	-	-	-	-	-
MDDHOLLC_01998	2.13e-114	yhcP	-	-	-	-	-	-	-
MDDHOLLC_01999	1.22e-148	yhcQ	-	-	M	-	-	-	Spore coat protein
MDDHOLLC_02000	0.0	yhcR	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01081,ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
MDDHOLLC_02001	7.55e-136	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
MDDHOLLC_02002	1.26e-213	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
MDDHOLLC_02003	1.88e-92	yhcU	-	-	S	-	-	-	Family of unknown function (DUF5365)
MDDHOLLC_02004	3.54e-90	yhcV	-	-	S	-	-	-	COG0517 FOG CBS domain
MDDHOLLC_02005	3.41e-161	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
MDDHOLLC_02006	0.0	yhcX	-	-	K	-	-	-	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MDDHOLLC_02007	0.0	yhxA	-	-	E	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MDDHOLLC_02008	8.57e-134	glpP	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MDDHOLLC_02009	2.32e-198	glpF	-	-	G	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
MDDHOLLC_02010	1.77e-299	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MDDHOLLC_02011	1.79e-55	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MDDHOLLC_02012	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MDDHOLLC_02013	0.0	pgcA	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
MDDHOLLC_02014	6.59e-257	yhcY	2.7.13.3	-	T	ko:K02480	-	ko00000,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_02015	3.83e-142	yhcZ	-	-	K	ko:K02479	-	ko00000,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MDDHOLLC_02016	9.77e-116	yhdA	1.7.1.6	-	S	ko:K03206	-	ko00000,ko01000	NADPH-dependent FMN reductase
MDDHOLLC_02017	6.98e-53	yhdB	-	-	S	-	-	-	YhdB-like protein
MDDHOLLC_02018	1.46e-71	yhdC	-	-	S	-	-	-	Protein of unknown function (DUF3889)
MDDHOLLC_02019	4.93e-296	lytF	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MDDHOLLC_02020	7.66e-96	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
MDDHOLLC_02021	0.0	ygxB	-	-	M	-	-	-	Conserved TM helix
MDDHOLLC_02022	0.0	spoVR	-	-	S	ko:K06415	-	ko00000	Stage V sporulation protein R
MDDHOLLC_02023	1.24e-283	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
MDDHOLLC_02024	1.56e-12	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
MDDHOLLC_02025	3.98e-171	lytE	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MDDHOLLC_02026	9.58e-191	citR	-	-	K	ko:K19242	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_02027	7.78e-260	citA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MDDHOLLC_02028	1.3e-204	yhdF	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_02029	1.78e-316	yhdG	-	-	E	ko:K03294	-	ko00000	amino acid
MDDHOLLC_02030	2.8e-265	yhdH	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MDDHOLLC_02031	8.62e-59	yhdK	-	-	S	-	-	-	Sigma-M inhibitor protein
MDDHOLLC_02032	1.69e-257	yhdL	-	-	S	-	-	-	Sigma factor regulator N-terminal
MDDHOLLC_02033	4.6e-113	sigM	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_02034	8.84e-140	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MDDHOLLC_02035	3.94e-307	yhdP	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MDDHOLLC_02036	1.97e-92	cueR	-	-	K	ko:K11923	-	ko00000,ko03000	transcriptional
MDDHOLLC_02037	3.11e-55	yhdR	2.6.1.1	-	E	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MDDHOLLC_02038	6.79e-208	yhdR	2.6.1.1	-	E	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MDDHOLLC_02039	1.11e-300	-	2.3.1.179	-	I	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MDDHOLLC_02040	0.0	yhdT	-	-	P	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MDDHOLLC_02041	1.75e-71	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MDDHOLLC_02042	7.92e-76	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MDDHOLLC_02043	1.23e-163	yhdW	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
MDDHOLLC_02044	1.45e-08	yhdX	-	-	S	-	-	-	Uncharacterized protein YhdX
MDDHOLLC_02045	1.91e-261	yhdY	-	-	M	ko:K16052	-	ko00000,ko02000	Mechanosensitive ion channel
MDDHOLLC_02046	6.9e-179	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
MDDHOLLC_02047	4.69e-199	nodB1	-	-	G	-	-	-	deacetylase
MDDHOLLC_02048	1.39e-196	dat	2.6.1.21	-	E	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	ko00000,ko00001,ko01000,ko01007	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
MDDHOLLC_02049	1e-113	pksA	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_02050	8.96e-123	ymcC	-	-	S	-	-	-	Membrane
MDDHOLLC_02051	7.15e-110	-	-	-	T	-	-	-	universal stress protein
MDDHOLLC_02053	0.0	yheI	-	-	V	ko:K18216,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MDDHOLLC_02054	0.0	yheH	-	-	V	ko:K18217,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MDDHOLLC_02055	6.68e-143	yheG	-	-	GM	-	-	-	NAD(P)H-binding
MDDHOLLC_02057	3.3e-39	sspB	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
MDDHOLLC_02058	4.28e-49	yheE	-	-	S	-	-	-	Family of unknown function (DUF5342)
MDDHOLLC_02059	0.0	yheD	-	-	HJ	-	-	-	YheC/D like ATP-grasp
MDDHOLLC_02060	4.41e-272	yheC	-	-	HJ	-	-	-	YheC/D like ATP-grasp
MDDHOLLC_02061	3.19e-263	yheB	-	-	S	-	-	-	Belongs to the UPF0754 family
MDDHOLLC_02062	3.3e-70	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
MDDHOLLC_02063	5.35e-253	yhaZ	-	-	L	-	-	-	DNA alkylation repair enzyme
MDDHOLLC_02064	9.87e-204	yhaX	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
MDDHOLLC_02065	0.0	hemZ	-	-	H	-	-	-	coproporphyrinogen III oxidase
MDDHOLLC_02066	2.89e-316	-	1.14.13.59	-	Q	ko:K03897	ko00310,ko01120,map00310,map01120	ko00000,ko00001,ko01000	L-lysine 6-monooxygenase (NADPH-requiring)
MDDHOLLC_02067	1.41e-266	yhaU	-	-	P	ko:K03455	-	ko00000	COG0475 Kef-type K transport systems, membrane components
MDDHOLLC_02068	8.88e-112	-	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
MDDHOLLC_02070	8.29e-175	yhaR	-	-	I	-	-	-	enoyl-CoA hydratase
MDDHOLLC_02071	7.01e-20	-	-	-	S	-	-	-	YhzD-like protein
MDDHOLLC_02072	5.34e-213	yhaQ	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_02073	2.05e-278	yhaP	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	COG1668 ABC-type Na efflux pump, permease component
MDDHOLLC_02074	2.91e-297	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	DNA repair exonuclease
MDDHOLLC_02075	0.0	yhaN	-	-	L	-	-	-	AAA domain
MDDHOLLC_02076	2.48e-226	yhaM	-	-	L	ko:K03698	-	ko00000,ko01000,ko03019	Shows a 3'-5' exoribonuclease activity
MDDHOLLC_02077	5.79e-43	yhaL	-	-	S	-	-	-	Sporulation protein YhaL
MDDHOLLC_02078	1.53e-184	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MDDHOLLC_02079	6.43e-41	-	-	-	-	-	-	-	-
MDDHOLLC_02080	1.29e-123	yhaK	-	-	S	-	-	-	Putative zincin peptidase
MDDHOLLC_02081	1.2e-72	yhaI	-	-	S	-	-	-	Protein of unknown function (DUF1878)
MDDHOLLC_02082	8.17e-147	hpr	-	-	K	ko:K09682	-	ko00000,ko03000	Negative regulator of protease production and sporulation
MDDHOLLC_02083	4.74e-55	yhaH	-	-	S	-	-	-	YtxH-like protein
MDDHOLLC_02084	2.55e-24	-	-	-	-	-	-	-	-
MDDHOLLC_02085	8.25e-100	trpP	-	-	S	-	-	-	Tryptophan transporter TrpP
MDDHOLLC_02086	1.69e-258	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MDDHOLLC_02087	8.27e-105	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MDDHOLLC_02088	1.82e-174	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	transporter (ATP-binding protein)
MDDHOLLC_02089	2.24e-281	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
MDDHOLLC_02090	3.38e-159	ecsC	-	-	S	-	-	-	EcsC protein family
MDDHOLLC_02091	1.3e-212	yhaA	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
MDDHOLLC_02092	1.39e-311	yhfA	-	-	C	-	-	-	membrane
MDDHOLLC_02093	3.1e-117	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
MDDHOLLC_02094	0.0	pbpF	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MDDHOLLC_02095	2.99e-258	hemE	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MDDHOLLC_02096	1.29e-231	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
MDDHOLLC_02097	0.0	hemY	1.3.3.15, 1.3.3.4	-	H	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MDDHOLLC_02098	3.1e-131	yhgD	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_02099	0.0	yhgE	-	-	S	ko:K01421	-	ko00000	YhgE Pip N-terminal domain protein
MDDHOLLC_02100	5.92e-235	fabHB	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MDDHOLLC_02102	8.97e-252	yhfE	-	-	G	-	-	-	peptidase M42
MDDHOLLC_02103	3.43e-282	gltT	-	-	C	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MDDHOLLC_02105	6.65e-180	yhfI	-	-	S	-	-	-	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
MDDHOLLC_02106	3.07e-240	lplJ	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
MDDHOLLC_02107	5.81e-139	yhfK	-	-	GM	-	-	-	NmrA-like family
MDDHOLLC_02108	0.0	yhfL	6.2.1.3	-	IQ	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
MDDHOLLC_02109	7.96e-85	yhfM	-	-	-	-	-	-	-
MDDHOLLC_02110	2.33e-284	yhfN	-	-	O	-	-	-	Peptidase M48
MDDHOLLC_02111	1.84e-260	aprE	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MDDHOLLC_02112	3.48e-190	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
MDDHOLLC_02113	1.73e-133	yhfR	5.4.2.12	-	G	ko:K15634,ko:K15640	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the phosphoglycerate mutase family
MDDHOLLC_02114	2.48e-253	yhfS	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
MDDHOLLC_02115	0.0	vraA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
MDDHOLLC_02116	7.56e-116	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
MDDHOLLC_02117	3.24e-276	hemAT	-	-	NT	ko:K06595	-	ko00000,ko02035	chemotaxis protein
MDDHOLLC_02118	0.0	yhfW	-	-	CE	-	-	-	COG0665 Glycine D-amino acid oxidases (deaminating)
MDDHOLLC_02119	8.26e-129	yhxC	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_02120	3.87e-42	yhzC	-	-	S	-	-	-	IDEAL
MDDHOLLC_02121	1.09e-141	comK	-	-	K	ko:K02250	ko02024,map02024	ko00000,ko00001,ko02044,ko03000	Competence transcription factor
MDDHOLLC_02122	3.48e-86	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
MDDHOLLC_02123	7.01e-82	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
MDDHOLLC_02124	1.49e-161	yrpD	-	-	S	-	-	-	Domain of unknown function, YrpD
MDDHOLLC_02125	1.23e-57	yhjA	-	-	S	-	-	-	Excalibur calcium-binding domain
MDDHOLLC_02126	5.32e-63	-	-	-	S	-	-	-	Belongs to the UPF0145 family
MDDHOLLC_02127	0.0	yhjB	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MDDHOLLC_02128	5.59e-37	yhjC	-	-	S	-	-	-	Protein of unknown function (DUF3311)
MDDHOLLC_02129	1.68e-78	yhjD	-	-	-	-	-	-	-
MDDHOLLC_02130	5.48e-143	yhjE	-	-	S	-	-	-	SNARE associated Golgi protein
MDDHOLLC_02131	3.32e-119	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MDDHOLLC_02133	0.0	yhjG	-	-	CH	-	-	-	FAD binding domain
MDDHOLLC_02134	4.98e-48	yhjH	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_02135	3.31e-63	yhjH	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_02136	9.85e-262	yhjN	-	-	S	ko:K07120	-	ko00000	membrane
MDDHOLLC_02137	1.78e-266	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_02138	3.71e-140	-	-	-	K	-	-	-	QacR-like protein, C-terminal region
MDDHOLLC_02139	1.47e-121	yhjR	-	-	S	-	-	-	Rubrerythrin
MDDHOLLC_02140	1.07e-152	ydfS	-	-	S	-	-	-	Protein of unknown function (DUF421)
MDDHOLLC_02141	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	ATP-dependent helicase deoxyribonuclease subunit B
MDDHOLLC_02142	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
MDDHOLLC_02143	5.49e-282	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MDDHOLLC_02144	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	COG0419 ATPase involved in DNA repair
MDDHOLLC_02145	2.64e-67	yisB	-	-	V	-	-	-	COG1403 Restriction endonuclease
MDDHOLLC_02146	6.66e-43	gerPF	-	-	S	ko:K06299,ko:K06304	-	ko00000	Spore germination protein gerPA/gerPF
MDDHOLLC_02147	1.61e-84	gerPE	-	-	S	ko:K06303	-	ko00000	Spore germination protein GerPE
MDDHOLLC_02148	3e-33	gerPD	-	-	S	ko:K06302	-	ko00000	Spore germination protein
MDDHOLLC_02149	8.51e-109	gerPC	-	-	S	ko:K06301	-	ko00000	Spore germination protein
MDDHOLLC_02150	3.82e-47	gerPB	-	-	S	ko:K06300	-	ko00000	cell differentiation
MDDHOLLC_02151	1.28e-45	gerPA	-	-	S	ko:K06299	-	ko00000	Spore germination protein
MDDHOLLC_02152	1.03e-11	yisI	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
MDDHOLLC_02153	7.33e-217	yisK	-	-	Q	-	-	-	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
MDDHOLLC_02154	6.36e-78	yisL	-	-	S	-	-	-	UPF0344 protein
MDDHOLLC_02155	1.86e-124	yisN	-	-	S	-	-	-	Protein of unknown function (DUF2777)
MDDHOLLC_02156	0.0	asnO	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
MDDHOLLC_02157	8.61e-168	crtM	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	phytoene
MDDHOLLC_02158	9.34e-245	yisQ	-	-	V	-	-	-	Mate efflux family protein
MDDHOLLC_02159	2.43e-50	yisQ	-	-	V	-	-	-	Mate efflux family protein
MDDHOLLC_02160	1.16e-206	yisR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_02161	8.2e-181	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MDDHOLLC_02162	9.41e-195	yisS	1.1.1.18, 1.1.1.369, 1.1.1.370	-	S	ko:K00010,ko:K16043	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
MDDHOLLC_02163	3.76e-108	yisT	-	-	S	-	-	-	DinB family
MDDHOLLC_02164	1.84e-109	yisX	-	-	S	-	-	-	Pentapeptide repeats (9 copies)
MDDHOLLC_02165	3.78e-106	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_02166	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
MDDHOLLC_02167	3.69e-78	yitK	-	-	S	ko:K09767	-	ko00000	Belongs to the UPF0234 family
MDDHOLLC_02168	4.36e-204	yitL	-	-	S	ko:K00243	-	ko00000	protein conserved in bacteria
MDDHOLLC_02169	2.44e-218	-	-	-	S	ko:K07335	-	ko00000	ABC transporter substrate-binding protein PnrA-like
MDDHOLLC_02170	0.0	yvaQ	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
MDDHOLLC_02172	1.77e-199	yitS	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02173	6.56e-189	yitT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_02174	1.75e-32	ipi	-	-	S	-	-	-	Intracellular proteinase inhibitor
MDDHOLLC_02175	1.5e-36	-	-	-	S	-	-	-	Protein of unknown function (DUF3813)
MDDHOLLC_02176	1.49e-11	-	-	-	-	-	-	-	-
MDDHOLLC_02177	2.94e-196	-	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
MDDHOLLC_02178	1.24e-185	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
MDDHOLLC_02179	3.26e-68	yitW	-	-	S	-	-	-	metal-sulfur cluster biosynthetic enzyme
MDDHOLLC_02180	1.51e-84	fosB	-	-	H	ko:K11210,ko:K21252	-	ko00000,ko01000,ko01504	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
MDDHOLLC_02181	0.0	yitY	-	-	C	-	-	-	D-arabinono-1,4-lactone oxidase
MDDHOLLC_02182	1.18e-121	yitZ	-	-	G	-	-	-	Major Facilitator Superfamily
MDDHOLLC_02183	3.02e-254	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MDDHOLLC_02184	2.19e-291	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MDDHOLLC_02185	1.16e-139	argB	2.7.2.8	-	F	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
MDDHOLLC_02186	1.55e-274	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
MDDHOLLC_02187	6.35e-255	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
MDDHOLLC_02188	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
MDDHOLLC_02189	4.24e-211	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
MDDHOLLC_02190	2.77e-185	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MDDHOLLC_02191	2.94e-38	yjzC	-	-	S	-	-	-	YjzC-like protein
MDDHOLLC_02192	1.06e-32	yjzD	-	-	S	-	-	-	Protein of unknown function (DUF2929)
MDDHOLLC_02193	5.47e-179	yjaU	-	-	I	-	-	-	carboxylic ester hydrolase activity
MDDHOLLC_02194	6.81e-134	yjaV	-	-	-	-	-	-	-
MDDHOLLC_02195	9.04e-211	med	-	-	S	ko:K05519,ko:K07335	-	ko00000,ko03000	Transcriptional activator protein med
MDDHOLLC_02196	6.46e-37	comZ	-	-	S	ko:K02254	-	ko00000,ko02044	ComZ
MDDHOLLC_02197	1.35e-42	yjzB	-	-	-	-	-	-	-
MDDHOLLC_02198	7.63e-220	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MDDHOLLC_02199	3.86e-300	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MDDHOLLC_02200	1.84e-190	yjaZ	-	-	O	-	-	-	Zn-dependent protease
MDDHOLLC_02201	6.88e-231	appD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02202	8.8e-239	appF	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02203	0.0	appA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
MDDHOLLC_02204	1.16e-216	appB	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02205	3.37e-198	appC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02206	6.08e-110	-	-	-	H	-	-	-	Tellurite resistance protein TehB
MDDHOLLC_02207	1.07e-172	-	-	-	EGP	-	-	-	Transmembrane secretion effector
MDDHOLLC_02208	1.52e-188	yjbA	-	-	S	-	-	-	Belongs to the UPF0736 family
MDDHOLLC_02209	1.45e-233	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
MDDHOLLC_02210	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MDDHOLLC_02211	2.53e-213	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02212	5.09e-210	oppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02213	1.5e-256	oppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02214	1.22e-217	oppF	-	-	E	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02215	4.77e-293	-	-	-	S	-	-	-	Putative glycosyl hydrolase domain
MDDHOLLC_02216	7.3e-131	yjbC	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_02217	2.47e-88	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MDDHOLLC_02218	5.59e-141	yjbE	-	-	P	-	-	-	Integral membrane protein TerC family
MDDHOLLC_02219	9.78e-150	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MDDHOLLC_02220	2.49e-276	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
MDDHOLLC_02221	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
MDDHOLLC_02222	3.14e-27	-	-	-	-	-	-	-	-
MDDHOLLC_02223	6.05e-220	yjbH	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
MDDHOLLC_02224	1.22e-93	yjbI	-	-	S	ko:K06886	-	ko00000	Bacterial-like globin
MDDHOLLC_02225	2.99e-150	yjbJ	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MDDHOLLC_02226	3.34e-124	yjbK	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02227	6.79e-79	yjbL	-	-	S	-	-	-	Belongs to the UPF0738 family
MDDHOLLC_02228	5e-138	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	GTP pyrophosphokinase
MDDHOLLC_02229	1.25e-174	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MDDHOLLC_02230	2.01e-212	rluD	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
MDDHOLLC_02231	5.9e-181	prpE	3.1.3.16, 3.6.1.41	-	T	ko:K01090,ko:K01525	ko00230,map00230	ko00000,ko00001,ko01000	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
MDDHOLLC_02232	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MDDHOLLC_02233	1.91e-175	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MDDHOLLC_02234	3.85e-137	tenI	5.3.99.10	-	H	ko:K10810	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Transcriptional regulator TenI
MDDHOLLC_02235	1.26e-265	thiO	1.4.3.19, 1.4.5.1	-	E	ko:K00285,ko:K03153	ko00360,ko00730,ko01100,map00360,map00730,map01100	ko00000,ko00001,ko01000	Glycine oxidase
MDDHOLLC_02236	4.53e-41	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	Thiamine biosynthesis
MDDHOLLC_02237	7.36e-173	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MDDHOLLC_02238	6.18e-238	thiF	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MDDHOLLC_02239	3.03e-189	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
MDDHOLLC_02240	6.85e-180	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
MDDHOLLC_02241	2.28e-123	yjbX	-	-	S	-	-	-	Spore coat protein
MDDHOLLC_02242	2.1e-108	cotZ	-	-	S	ko:K06344	-	ko00000	Spore coat protein
MDDHOLLC_02243	4.28e-121	cotY	-	-	S	ko:K06343	-	ko00000	Spore coat protein Z
MDDHOLLC_02244	2.61e-100	cotX	-	-	S	ko:K06342	-	ko00000	Spore Coat Protein X and V domain
MDDHOLLC_02245	8.38e-36	cotW	-	-	-	ko:K06341	-	ko00000	-
MDDHOLLC_02246	2.67e-68	cotV	-	-	S	ko:K06340	-	ko00000	Spore Coat Protein X and V domain
MDDHOLLC_02247	2.05e-73	yjcA	-	-	S	-	-	-	Protein of unknown function (DUF1360)
MDDHOLLC_02250	2.57e-51	spoVIF	-	-	S	-	-	-	Stage VI sporulation protein F
MDDHOLLC_02251	7.62e-63	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_02252	3.13e-59	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_02253	0.0	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_02254	5e-48	-	-	-	-	-	-	-	-
MDDHOLLC_02255	1.9e-177	blm	3.5.2.6	-	S	ko:K17837	ko01501,map01501	ko00000,ko00001,ko01000	Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family
MDDHOLLC_02256	5.35e-159	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MDDHOLLC_02257	4.81e-169	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
MDDHOLLC_02258	1.76e-47	-	-	-	K	-	-	-	SpoVT / AbrB like domain
MDDHOLLC_02260	1.18e-94	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_02261	2.43e-121	yjcG	-	-	J	-	-	-	Belongs to the 2H phosphoesterase superfamily. YjcG family
MDDHOLLC_02262	1.43e-163	yjcH	-	-	P	ko:K07214	-	ko00000	COG2382 Enterochelin esterase and related enzymes
MDDHOLLC_02263	2.18e-268	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MDDHOLLC_02264	2.7e-278	metC	4.4.1.8	-	E	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MDDHOLLC_02266	2.1e-29	-	-	-	-	-	-	-	-
MDDHOLLC_02268	1.53e-250	-	-	-	M	-	-	-	nucleic acid phosphodiester bond hydrolysis
MDDHOLLC_02270	3.5e-28	-	-	-	-	-	-	-	-
MDDHOLLC_02271	1.16e-36	-	-	-	-	-	-	-	-
MDDHOLLC_02273	5.52e-35	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MDDHOLLC_02275	1.73e-92	-	-	-	D	-	-	-	COG1192 ATPases involved in chromosome partitioning
MDDHOLLC_02276	2.24e-10	-	-	-	L	-	-	-	COG2963 Transposase and inactivated derivatives
MDDHOLLC_02277	7.01e-43	yqaS	-	-	L	-	-	-	DNA packaging
MDDHOLLC_02278	1.11e-208	penP	3.5.2.6	-	V	ko:K17836,ko:K18766	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	beta-lactamase
MDDHOLLC_02279	1.81e-60	yjcS	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
MDDHOLLC_02280	1.77e-316	yfjF	-	-	EGP	-	-	-	Belongs to the major facilitator superfamily
MDDHOLLC_02281	1.75e-105	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_02282	5.44e-281	yvfO	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
MDDHOLLC_02283	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MDDHOLLC_02284	9.12e-237	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MDDHOLLC_02285	2.37e-271	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MDDHOLLC_02286	0.0	lacE	2.7.1.207	-	G	ko:K02761,ko:K02787,ko:K02788	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MDDHOLLC_02287	8.91e-67	celC	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_02288	0.0	lacG	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MDDHOLLC_02289	1.35e-143	yulB	-	-	K	ko:K02530	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MDDHOLLC_02290	1.48e-16	yulB	-	-	K	ko:K02530	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MDDHOLLC_02291	2.69e-157	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
MDDHOLLC_02293	1.01e-135	-	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
MDDHOLLC_02294	1.57e-30	yjfB	-	-	S	-	-	-	Putative motility protein
MDDHOLLC_02295	8.23e-88	yjgA	-	-	T	-	-	-	Protein of unknown function (DUF2809)
MDDHOLLC_02296	5.57e-129	yjgB	-	-	S	-	-	-	Domain of unknown function (DUF4309)
MDDHOLLC_02297	0.0	-	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase, alpha subunit
MDDHOLLC_02298	8.96e-117	yjgD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MDDHOLLC_02299	2.98e-287	yjiB	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MDDHOLLC_02300	1.06e-279	yjiC	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MDDHOLLC_02301	1.73e-40	-	-	-	-	-	-	-	-
MDDHOLLC_02302	1.14e-145	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
MDDHOLLC_02303	1.77e-25	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
MDDHOLLC_02304	1.45e-158	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	transport system, permease component
MDDHOLLC_02305	8.84e-166	yjkB	-	-	P	ko:K02068	-	ko00000,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02306	6.53e-224	yjlA	-	-	EG	-	-	-	Putative multidrug resistance efflux transporter
MDDHOLLC_02307	1.17e-116	yjlB	-	-	S	-	-	-	Cupin domain
MDDHOLLC_02308	1.7e-87	yjlC	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MDDHOLLC_02309	1.76e-279	yjlD	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MDDHOLLC_02310	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
MDDHOLLC_02311	0.0	-	-	-	G	ko:K03292	-	ko00000	symporter YjmB
MDDHOLLC_02312	7.94e-158	exuR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
MDDHOLLC_02313	7.33e-45	exuR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
MDDHOLLC_02314	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
MDDHOLLC_02315	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
MDDHOLLC_02316	2.6e-112	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
MDDHOLLC_02317	1.76e-39	-	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MDDHOLLC_02318	2.09e-105	-	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MDDHOLLC_02319	6.68e-20	-	-	-	V	ko:K01990,ko:K20459	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_02321	7.56e-166	yjnA	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MDDHOLLC_02322	1.19e-102	yjoA	-	-	S	-	-	-	DinB family
MDDHOLLC_02323	2.68e-275	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
MDDHOLLC_02325	8.26e-222	xlyB	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
MDDHOLLC_02326	2.73e-80	yjqA	-	-	S	-	-	-	Bacterial PH domain
MDDHOLLC_02327	7.55e-142	yjqB	-	-	S	-	-	-	phage-related replication protein
MDDHOLLC_02328	7.61e-144	xkdA	-	-	E	-	-	-	IrrE N-terminal-like domain
MDDHOLLC_02329	6.52e-75	xre	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MDDHOLLC_02331	2.82e-192	xkdC	-	-	L	-	-	-	Bacterial dnaA protein
MDDHOLLC_02335	1.07e-110	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MDDHOLLC_02336	2.38e-140	xtmA	-	-	L	ko:K07474	-	ko00000	phage terminase small subunit
MDDHOLLC_02337	3.51e-265	xtmB	-	-	S	ko:K06909	-	ko00000	phage terminase, large subunit
MDDHOLLC_02338	3.45e-301	xkdE3	-	-	S	-	-	-	portal protein
MDDHOLLC_02339	2.52e-118	xkdF3	-	-	L	-	-	-	Putative phage serine protease XkdF
MDDHOLLC_02340	8.3e-203	xkdG	-	-	S	-	-	-	Phage capsid family
MDDHOLLC_02341	2.17e-61	yqbG	-	-	S	-	-	-	Protein of unknown function (DUF3199)
MDDHOLLC_02342	2.02e-56	-	-	-	S	-	-	-	Domain of unknown function (DUF3599)
MDDHOLLC_02343	2.98e-24	xkdI	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
MDDHOLLC_02344	4.99e-73	xkdJ	-	-	-	-	-	-	-
MDDHOLLC_02345	3.17e-20	-	-	-	-	-	-	-	-
MDDHOLLC_02346	2.82e-288	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
MDDHOLLC_02347	8.21e-97	xkdM	-	-	S	-	-	-	Phage tail tube protein
MDDHOLLC_02348	7.28e-96	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
MDDHOLLC_02349	4.33e-27	-	-	-	-	-	-	-	-
MDDHOLLC_02350	3.84e-285	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
MDDHOLLC_02351	6.56e-145	xkdP	-	-	S	-	-	-	Lysin motif
MDDHOLLC_02352	2.66e-206	xkdQ	-	-	G	-	-	-	NLP P60 protein
MDDHOLLC_02353	2.51e-43	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
MDDHOLLC_02354	2.86e-76	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
MDDHOLLC_02355	1.08e-212	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MDDHOLLC_02356	2.03e-112	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
MDDHOLLC_02357	3.63e-37	-	-	-	-	-	-	-	-
MDDHOLLC_02358	1.09e-113	-	-	-	-	-	-	-	-
MDDHOLLC_02359	1.52e-45	-	-	-	-	-	-	-	-
MDDHOLLC_02361	1.55e-38	xkdX	-	-	-	-	-	-	-
MDDHOLLC_02362	7.1e-175	xepA	-	-	-	-	-	-	-
MDDHOLLC_02363	6.44e-50	xhlA	-	-	S	-	-	-	Haemolysin XhlA
MDDHOLLC_02364	3.87e-51	xhlB	-	-	S	-	-	-	SPP1 phage holin
MDDHOLLC_02365	1.42e-214	xlyA	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	n-acetylmuramoyl-L-alanine amidase
MDDHOLLC_02366	2.53e-31	spoIISB	-	-	S	ko:K06389	-	ko00000	Stage II sporulation protein SB
MDDHOLLC_02367	7.37e-170	spoIISA	-	-	S	ko:K06388	-	ko00000	Toxin SpoIISA, type II toxin-antitoxin system
MDDHOLLC_02368	7.07e-226	pit	-	-	P	ko:K03306	-	ko00000	phosphate transporter
MDDHOLLC_02369	1.85e-144	ykaA	-	-	P	ko:K07220	-	ko00000	COG1392 Phosphate transport regulator (distant homolog of PhoU)
MDDHOLLC_02370	9.38e-312	steT	-	-	E	ko:K03294	-	ko00000	amino acid
MDDHOLLC_02371	8.67e-228	ykcA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MDDHOLLC_02372	0.0	ykcB	-	-	M	-	-	-	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MDDHOLLC_02373	5.21e-228	ykcC	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MDDHOLLC_02375	3.06e-275	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MDDHOLLC_02376	0.0	yubD	-	-	P	-	-	-	Major Facilitator Superfamily
MDDHOLLC_02377	8.43e-198	dppA	-	-	E	ko:K16203	-	ko00000,ko01000,ko01002	D-aminopeptidase
MDDHOLLC_02378	2.3e-203	dppB	-	-	P	ko:K16200	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02379	6.59e-227	dppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDDHOLLC_02380	9.63e-164	dppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02381	1.46e-23	dppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02382	0.0	dppE	-	-	E	ko:K16199	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MDDHOLLC_02383	3.97e-226	ykfA	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
MDDHOLLC_02384	5.85e-253	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
MDDHOLLC_02385	2.45e-214	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MDDHOLLC_02386	5.44e-230	ykfD	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MDDHOLLC_02387	2.82e-261	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconolactonase
MDDHOLLC_02388	1.15e-201	ykgA	-	-	E	-	-	-	Amidinotransferase
MDDHOLLC_02389	5.33e-67	ykhA	-	-	I	-	-	-	Acyl-CoA hydrolase
MDDHOLLC_02390	2.59e-130	ykkB	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MDDHOLLC_02391	3.36e-68	ykkC	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Multidrug resistance protein
MDDHOLLC_02392	1.22e-64	ykkD	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Multidrug resistance protein
MDDHOLLC_02393	1.66e-217	purU	3.5.1.10	-	F	ko:K01433	ko00630,ko00670,map00630,map00670	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
MDDHOLLC_02394	5.3e-263	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MDDHOLLC_02395	2.09e-285	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MDDHOLLC_02396	1.69e-55	ohrA	-	-	O	-	-	-	Organic hydroperoxide resistance protein
MDDHOLLC_02397	5e-94	ohrR	-	-	K	-	-	-	COG1846 Transcriptional regulators
MDDHOLLC_02398	1.92e-92	ohrB	-	-	O	-	-	-	Organic hydroperoxide resistance protein
MDDHOLLC_02399	9.92e-77	-	-	-	D	-	-	-	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MDDHOLLC_02401	5.84e-274	-	-	-	M	-	-	-	Glycosyl transferase family 2
MDDHOLLC_02402	5.86e-176	-	-	-	M	-	-	-	PFAM Collagen triple helix repeat (20 copies)
MDDHOLLC_02403	1.09e-274	-	-	-	EGP	ko:K05820	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_02404	1.69e-88	nsr	-	-	T	-	-	-	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MDDHOLLC_02405	1.95e-53	nsr	-	-	T	-	-	-	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MDDHOLLC_02406	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MDDHOLLC_02407	7.39e-226	isp	-	-	O	ko:K13275	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MDDHOLLC_02408	2.12e-188	yojH	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MDDHOLLC_02409	2.66e-170	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
MDDHOLLC_02410	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_02411	2.31e-126	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
MDDHOLLC_02412	1.27e-309	ydhD	-	-	M	-	-	-	Glycosyl hydrolase
MDDHOLLC_02414	1.67e-307	mgtE	-	-	P	ko:K06213	-	ko00000,ko02000	Acts as a magnesium transporter
MDDHOLLC_02415	1.23e-69	tnrA	-	-	K	-	-	-	transcriptional
MDDHOLLC_02416	1.11e-23	-	-	-	-	-	-	-	-
MDDHOLLC_02417	5.25e-37	ykoL	-	-	-	-	-	-	-
MDDHOLLC_02418	5.46e-105	ykoM	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
MDDHOLLC_02419	7.68e-129	ykoP	-	-	G	-	-	-	polysaccharide deacetylase
MDDHOLLC_02420	6.56e-190	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
MDDHOLLC_02421	1e-243	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
MDDHOLLC_02422	3.83e-199	ku	-	-	L	ko:K10979	ko03450,map03450	ko00000,ko00001,ko03400	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MDDHOLLC_02423	2e-61	ykoX	-	-	S	-	-	-	membrane-associated protein
MDDHOLLC_02424	3.54e-52	ykoX	-	-	S	-	-	-	membrane-associated protein
MDDHOLLC_02425	1.38e-171	ykoY	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
MDDHOLLC_02427	2.25e-127	sigI	-	-	K	ko:K03093	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02428	2.86e-150	ykrI	-	-	S	-	-	-	Anti-sigma factor N-terminus
MDDHOLLC_02429	5.7e-36	sspD	-	-	S	ko:K06421	-	ko00000	small acid-soluble spore protein
MDDHOLLC_02430	9.35e-161	ykrK	-	-	S	-	-	-	Domain of unknown function (DUF1836)
MDDHOLLC_02431	1.05e-198	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
MDDHOLLC_02432	3.8e-308	ktrD	-	-	P	-	-	-	COG0168 Trk-type K transport systems, membrane components
MDDHOLLC_02433	4.08e-146	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
MDDHOLLC_02434	1.78e-31	ykzE	-	-	-	-	-	-	-
MDDHOLLC_02435	1.52e-240	ykrP	-	-	G	-	-	-	COG3594 Fucose 4-O-acetylase and related acetyltransferases
MDDHOLLC_02436	0.0	kinE	2.7.13.3	-	T	ko:K13533	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_02437	6.51e-114	ogt	2.1.1.63	-	L	ko:K00567,ko:K13531	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MDDHOLLC_02439	1.09e-251	mtnA	5.3.1.23	-	E	ko:K08963	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MDDHOLLC_02440	4.05e-286	mtnK	2.7.1.100	-	F	ko:K00899	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MDDHOLLC_02441	1.35e-191	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MDDHOLLC_02442	5.78e-288	mtnE	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
MDDHOLLC_02443	7.51e-287	mtnW	5.3.2.5	-	G	ko:K08965	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
MDDHOLLC_02444	2.85e-164	mtnX	3.1.3.87	-	E	ko:K08966	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MDDHOLLC_02445	3.05e-145	mtnB	4.2.1.109	-	E	ko:K08964	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
MDDHOLLC_02446	6.12e-123	mtnD	1.13.11.53, 1.13.11.54	-	S	ko:K08967	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MDDHOLLC_02448	0.0	kinD	2.7.13.3	-	T	ko:K13532	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MDDHOLLC_02449	3.91e-100	ykvE	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
MDDHOLLC_02450	4.04e-169	motB	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
MDDHOLLC_02451	4.74e-176	motA	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
MDDHOLLC_02452	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
MDDHOLLC_02453	3.5e-228	ykvI	-	-	S	-	-	-	membrane
MDDHOLLC_02454	9.14e-245	-	-	-	-	-	-	-	-
MDDHOLLC_02455	2.72e-162	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MDDHOLLC_02456	1.26e-102	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
MDDHOLLC_02457	5.06e-179	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MDDHOLLC_02458	2.56e-124	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MDDHOLLC_02459	2.54e-60	ykvR	-	-	S	-	-	-	Protein of unknown function (DUF3219)
MDDHOLLC_02460	5.43e-35	ykvS	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02461	2.92e-38	-	-	-	-	-	-	-	-
MDDHOLLC_02462	1.2e-141	ykvT	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell Wall Hydrolase
MDDHOLLC_02463	7.63e-306	ykvU	-	-	S	-	-	-	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_02464	1.22e-113	stoA	-	-	CO	-	-	-	thiol-disulfide
MDDHOLLC_02465	0.0	zosA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
MDDHOLLC_02466	5.5e-262	ykvY	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
MDDHOLLC_02468	3.93e-222	ykvZ	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_02469	6.33e-178	glcT	-	-	K	ko:K03480,ko:K03488	-	ko00000,ko03000	antiterminator
MDDHOLLC_02470	0.0	ptsG	2.7.1.199	-	G	ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_02471	1.51e-53	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPr
MDDHOLLC_02472	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MDDHOLLC_02473	3.63e-50	splA	-	-	S	ko:K06315	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_02474	2.39e-254	splB	4.1.99.14	-	L	ko:K03716	-	ko00000,ko01000	Spore photoproduct lyase
MDDHOLLC_02475	0.0	mcpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MDDHOLLC_02476	1.4e-203	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
MDDHOLLC_02477	5.31e-155	ykwD	-	-	J	-	-	-	protein with SCP PR1 domains
MDDHOLLC_02478	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
MDDHOLLC_02479	0.0	kinA	2.7.13.3	-	T	ko:K02491	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_02480	3.82e-274	patA	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
MDDHOLLC_02481	6.38e-15	-	-	-	-	-	-	-	-
MDDHOLLC_02482	4.75e-214	cheV	-	-	T	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	Chemotaxis protein CheV
MDDHOLLC_02483	5.07e-108	ykyB	-	-	S	-	-	-	YkyB-like protein
MDDHOLLC_02484	8.89e-306	ykuC	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_02485	8.88e-117	ykuD	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02486	2.12e-196	ykuE	-	-	S	ko:K07098	-	ko00000	Metallophosphoesterase
MDDHOLLC_02487	1.35e-107	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_02488	4.15e-64	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_02490	3.67e-295	ykuI	-	-	T	-	-	-	Diguanylate phosphodiesterase
MDDHOLLC_02491	3.63e-50	ykuJ	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02492	2.52e-119	ykuK	-	-	S	ko:K09776	-	ko00000	Ribonuclease H-like
MDDHOLLC_02493	3.09e-35	ykzF	-	-	S	-	-	-	Antirepressor AbbA
MDDHOLLC_02494	8.55e-99	ykuL	-	-	S	-	-	-	CBS domain
MDDHOLLC_02495	5.36e-215	ccpC	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_02496	1.83e-116	ykuN	-	-	C	ko:K03839	-	ko00000	Flavodoxin
MDDHOLLC_02497	2.35e-211	ykuO	-	-	-	-	-	-	-
MDDHOLLC_02498	6.2e-103	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
MDDHOLLC_02499	1.19e-121	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MDDHOLLC_02500	7.99e-276	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MDDHOLLC_02501	2.15e-52	ykuS	-	-	S	-	-	-	Belongs to the UPF0180 family
MDDHOLLC_02502	1.48e-179	ykuT	-	-	M	ko:K22044	-	ko00000,ko02000	Mechanosensitive ion channel
MDDHOLLC_02503	2.51e-98	ykuV	-	-	CO	-	-	-	thiol-disulfide
MDDHOLLC_02504	3.04e-126	rok	-	-	K	-	-	-	Repressor of ComK
MDDHOLLC_02505	1.98e-215	yknT	-	-	-	ko:K06437	-	ko00000	-
MDDHOLLC_02506	3.89e-139	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MDDHOLLC_02507	1.64e-239	moeB	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MDDHOLLC_02508	3.94e-309	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	molybdopterin
MDDHOLLC_02509	4.38e-120	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
MDDHOLLC_02510	8.37e-108	moaE	2.8.1.12	-	H	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	COG0314 Molybdopterin converting factor, large subunit
MDDHOLLC_02511	3.43e-45	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MDDHOLLC_02512	1.89e-139	yknW	-	-	S	-	-	-	Yip1 domain
MDDHOLLC_02513	3.47e-35	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDDHOLLC_02514	2.93e-189	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDDHOLLC_02515	1.96e-156	yknY	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_02516	3.47e-268	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
MDDHOLLC_02517	1.32e-169	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_02518	4.75e-214	pfkB	2.7.1.56	-	G	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
MDDHOLLC_02519	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
MDDHOLLC_02520	3.77e-138	sipT	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MDDHOLLC_02521	4.3e-49	ykoA	-	-	-	-	-	-	-
MDDHOLLC_02522	0.0	ykpA	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MDDHOLLC_02523	4.91e-211	panE1	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MDDHOLLC_02524	1.34e-299	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
MDDHOLLC_02525	4.47e-18	-	-	-	S	-	-	-	Uncharacterized protein YkpC
MDDHOLLC_02526	3.72e-235	mreBH	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod-share determining protein MreBH
MDDHOLLC_02527	7.46e-59	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	of stationary sporulation gene expression
MDDHOLLC_02528	1.61e-310	kinC	2.7.13.3	-	T	ko:K07698	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MDDHOLLC_02529	4.16e-194	ykqA	-	-	P	-	-	-	Gamma-glutamyl cyclotransferase, AIG2-like
MDDHOLLC_02530	9.71e-148	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
MDDHOLLC_02531	3.68e-167	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MDDHOLLC_02532	6.01e-226	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MDDHOLLC_02533	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MDDHOLLC_02534	4.45e-42	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
MDDHOLLC_02535	2.5e-186	ykrA	-	-	S	-	-	-	hydrolases of the HAD superfamily
MDDHOLLC_02536	1.14e-130	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MDDHOLLC_02537	1.21e-06	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
MDDHOLLC_02538	5.36e-132	ykyA	-	-	L	-	-	-	Putative cell-wall binding lipoprotein
MDDHOLLC_02539	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02540	5.29e-37	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02541	9.17e-255	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02542	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02543	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02544	5.71e-291	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02545	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02546	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02547	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	polyketide synthase
MDDHOLLC_02548	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02549	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02550	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02551	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02552	1.66e-135	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02553	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02554	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02555	0.0	-	-	-	IQ	-	-	-	Phosphopantetheine attachment site
MDDHOLLC_02556	1.85e-264	-	-	-	V	-	-	-	Beta-lactamase
MDDHOLLC_02557	7.79e-261	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MDDHOLLC_02558	1.01e-226	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MDDHOLLC_02559	8.47e-301	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MDDHOLLC_02560	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MDDHOLLC_02561	3.24e-58	slp	-	-	CO	-	-	-	COG0526, thiol-disulfide isomerase and thioredoxins
MDDHOLLC_02562	8e-185	pdaA_2	3.5.1.104	-	G	ko:K01567,ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
MDDHOLLC_02563	0.0	speA	4.1.1.17, 4.1.1.19	-	E	ko:K01581,ko:K01585	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Arginine
MDDHOLLC_02564	1.9e-56	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
MDDHOLLC_02565	3.32e-154	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
MDDHOLLC_02566	7.89e-32	ykzI	-	-	-	-	-	-	-
MDDHOLLC_02567	3.31e-195	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase
MDDHOLLC_02568	5.32e-108	ykzC	-	-	S	-	-	-	Acetyltransferase (GNAT) family
MDDHOLLC_02569	0.0	mpl	3.4.24.28, 3.4.24.29	-	E	ko:K01400,ko:K01401,ko:K19351	ko01503,ko05150,map01503,map05150	ko00000,ko00001,ko01000,ko01002	Peptidase M4
MDDHOLLC_02570	6.19e-203	ylaA	-	-	-	-	-	-	-
MDDHOLLC_02571	2.23e-165	-	-	-	-	-	-	-	-
MDDHOLLC_02572	2.12e-58	ylaB	-	-	-	-	-	-	-
MDDHOLLC_02573	3.18e-118	ylaC	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_02575	8.65e-59	ylaE	-	-	-	-	-	-	-
MDDHOLLC_02576	5.62e-33	-	-	-	S	-	-	-	Family of unknown function (DUF5325)
MDDHOLLC_02577	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
MDDHOLLC_02578	4.05e-64	-	-	-	S	-	-	-	YlaH-like protein
MDDHOLLC_02579	1.37e-45	ylaI	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02580	1.83e-136	ylaJ	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MDDHOLLC_02581	1.05e-310	ylaK	-	-	T	ko:K07175	-	ko00000	ATPase related to phosphate starvation-inducible protein PhoH
MDDHOLLC_02582	2.02e-50	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MDDHOLLC_02583	3.9e-46	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MDDHOLLC_02584	8.95e-222	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
MDDHOLLC_02585	1.99e-58	ylaN	-	-	S	-	-	-	Belongs to the UPF0358 family
MDDHOLLC_02586	8.14e-201	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MDDHOLLC_02587	7.9e-41	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MDDHOLLC_02588	3.29e-307	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MDDHOLLC_02589	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MDDHOLLC_02590	1.41e-213	ctaA	-	-	O	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	ko00000,ko00001,ko00002,ko03029	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
MDDHOLLC_02591	3.57e-189	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MDDHOLLC_02592	1.99e-42	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MDDHOLLC_02593	1.39e-176	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MDDHOLLC_02594	0.0	ctaD	1.9.3.1	-	C	ko:K02274	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MDDHOLLC_02595	2.41e-141	ctaE	1.9.3.1	-	C	ko:K02276	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
MDDHOLLC_02596	2.04e-68	ctaF	1.9.3.1	-	C	ko:K02277	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
MDDHOLLC_02597	3.45e-210	ctaG	-	-	S	ko:K02862	-	ko00000	cytochrome c oxidase
MDDHOLLC_02598	2.39e-78	ylbA	-	-	S	-	-	-	YugN-like family
MDDHOLLC_02599	1.94e-95	ylbB	-	-	T	-	-	-	COG0517 FOG CBS domain
MDDHOLLC_02600	3.26e-254	ylbC	-	-	S	-	-	-	protein with SCP PR1 domains
MDDHOLLC_02601	1.64e-84	ylbD	-	-	S	-	-	-	Putative coat protein
MDDHOLLC_02602	1.73e-48	ylbE	-	-	S	-	-	-	YlbE-like protein
MDDHOLLC_02603	9.79e-58	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
MDDHOLLC_02604	2.78e-57	ylbG	-	-	S	-	-	-	UPF0298 protein
MDDHOLLC_02606	1.01e-124	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
MDDHOLLC_02607	3.5e-77	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MDDHOLLC_02608	4.57e-21	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MDDHOLLC_02609	1.68e-276	ylbJ	-	-	S	-	-	-	Sporulation integral membrane protein YlbJ
MDDHOLLC_02610	2.03e-177	ylbK	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
MDDHOLLC_02611	3.13e-75	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
MDDHOLLC_02612	1.37e-149	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
MDDHOLLC_02613	8.29e-292	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
MDDHOLLC_02614	4.69e-115	ylbN	-	-	S	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
MDDHOLLC_02615	1.71e-37	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
MDDHOLLC_02616	3.13e-111	ylbO	-	-	S	ko:K06314	-	ko00000,ko03000	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
MDDHOLLC_02617	4.63e-116	ylbP	-	-	K	-	-	-	n-acetyltransferase
MDDHOLLC_02618	5.63e-209	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MDDHOLLC_02619	0.0	bshC	-	-	S	ko:K22136	-	ko00000	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MDDHOLLC_02620	9.07e-102	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
MDDHOLLC_02621	6.76e-218	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MDDHOLLC_02622	2.4e-68	ftsL	-	-	D	-	-	-	Essential cell division protein
MDDHOLLC_02623	1.45e-26	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
MDDHOLLC_02624	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
MDDHOLLC_02625	0.0	spoVD	-	-	M	ko:K08384	ko00550,map00550	ko00000,ko00001,ko01011	stage V sporulation protein D
MDDHOLLC_02626	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MDDHOLLC_02627	2.87e-221	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MDDHOLLC_02628	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MDDHOLLC_02629	2.7e-236	spoVE	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MDDHOLLC_02630	5.69e-259	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MDDHOLLC_02631	3.2e-212	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
MDDHOLLC_02632	1.04e-176	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MDDHOLLC_02633	1.57e-298	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MDDHOLLC_02634	7.49e-214	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MDDHOLLC_02635	0.0	bpr	-	-	O	ko:K13276	-	ko00000,ko01000,ko01002,ko03110	COG1404 Subtilisin-like serine proteases
MDDHOLLC_02636	6.48e-215	spoIIGA	-	-	M	ko:K06383	-	ko00000,ko01000,ko01002	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
MDDHOLLC_02637	1.27e-117	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02638	1.05e-30	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02639	6.78e-149	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02640	1.4e-19	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02641	2.21e-184	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
MDDHOLLC_02642	0.0	argE	-	-	E	ko:K20895	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Acetylornithine deacetylase
MDDHOLLC_02643	2.82e-26	ylmC	-	-	S	-	-	-	sporulation protein
MDDHOLLC_02644	1.12e-204	ylmD	-	-	S	ko:K05810	-	ko00000,ko01000	Belongs to the multicopper oxidase YfiH RL5 family
MDDHOLLC_02645	1.05e-160	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MDDHOLLC_02646	4.61e-85	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MDDHOLLC_02647	5.12e-56	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	membrane
MDDHOLLC_02648	4.13e-180	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
MDDHOLLC_02649	1.85e-99	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
MDDHOLLC_02650	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MDDHOLLC_02651	1.59e-45	ylyA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
MDDHOLLC_02652	1.24e-103	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MDDHOLLC_02653	3.69e-208	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
MDDHOLLC_02654	6.32e-122	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MDDHOLLC_02655	3.28e-295	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Xanthine uracil
MDDHOLLC_02656	1.64e-210	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
MDDHOLLC_02657	2.12e-312	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MDDHOLLC_02658	3.09e-268	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
MDDHOLLC_02659	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarB family
MDDHOLLC_02660	8.69e-182	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
MDDHOLLC_02661	3.5e-220	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MDDHOLLC_02662	1.74e-161	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MDDHOLLC_02663	1.26e-101	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MDDHOLLC_02664	4.03e-180	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
MDDHOLLC_02665	3.87e-225	cysP	-	-	P	ko:K16331	-	ko00000,ko02000	phosphate transporter
MDDHOLLC_02666	1.77e-283	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
MDDHOLLC_02667	9.22e-141	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
MDDHOLLC_02668	1.35e-49	cobA	2.1.1.107	-	H	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
MDDHOLLC_02669	2.47e-85	cobA	2.1.1.107	-	H	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
MDDHOLLC_02670	4.11e-109	sirB	4.99.1.4	-	S	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sirohydrochlorin ferrochelatase
MDDHOLLC_02671	5.22e-65	sirB	4.99.1.4	-	S	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sirohydrochlorin ferrochelatase
MDDHOLLC_02672	9.22e-43	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
MDDHOLLC_02673	1.98e-41	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
MDDHOLLC_02674	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
MDDHOLLC_02675	0.0	yloB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
MDDHOLLC_02676	7.16e-197	yloC	-	-	S	-	-	-	stress-induced protein
MDDHOLLC_02677	3.97e-54	ylzA	-	-	S	ko:K09777	-	ko00000	Belongs to the UPF0296 family
MDDHOLLC_02678	4.91e-144	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
MDDHOLLC_02679	2.53e-38	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MDDHOLLC_02680	2.18e-287	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MDDHOLLC_02681	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MDDHOLLC_02682	4.8e-109	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MDDHOLLC_02683	5.32e-221	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MDDHOLLC_02684	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MDDHOLLC_02685	1.52e-263	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MDDHOLLC_02686	4.98e-178	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
MDDHOLLC_02687	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
MDDHOLLC_02688	2.53e-210	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MDDHOLLC_02689	1.24e-150	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
MDDHOLLC_02690	4.52e-154	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
MDDHOLLC_02691	3.49e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
MDDHOLLC_02692	3.65e-78	yloU	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_02693	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
MDDHOLLC_02694	4.15e-153	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
MDDHOLLC_02695	2.4e-201	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
MDDHOLLC_02696	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MDDHOLLC_02697	4.38e-121	fapR	-	-	K	-	-	-	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
MDDHOLLC_02698	3.14e-229	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MDDHOLLC_02699	1.53e-217	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02700	8.61e-168	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
MDDHOLLC_02701	1.15e-43	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MDDHOLLC_02702	1.19e-114	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MDDHOLLC_02703	4.63e-44	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MDDHOLLC_02704	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
MDDHOLLC_02705	1.87e-224	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MDDHOLLC_02706	5.87e-180	-	-	-	S	-	-	-	Phosphotransferase enzyme family
MDDHOLLC_02707	1.97e-66	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MDDHOLLC_02708	9.92e-302	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MDDHOLLC_02709	1.13e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
MDDHOLLC_02710	4.9e-49	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
MDDHOLLC_02711	3.41e-80	ylqD	-	-	S	-	-	-	YlqD protein
MDDHOLLC_02712	2.99e-98	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MDDHOLLC_02713	5.67e-176	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
MDDHOLLC_02714	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MDDHOLLC_02715	4.19e-202	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MDDHOLLC_02716	6.81e-174	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MDDHOLLC_02717	0.0	ylqG	-	-	-	-	-	-	-
MDDHOLLC_02718	6.94e-59	ylqH	-	-	S	ko:K04061	-	ko00000,ko02044	homolog of the cytoplasmic domain of flagellar protein FhlB
MDDHOLLC_02719	1.29e-89	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MDDHOLLC_02720	1.64e-138	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MDDHOLLC_02721	1.13e-205	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MDDHOLLC_02722	1.42e-213	dprA	-	-	LU	ko:K04096	-	ko00000	Rossmann fold nucleotide-binding protein involved in DNA uptake
MDDHOLLC_02723	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MDDHOLLC_02724	1.1e-313	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MDDHOLLC_02725	8.93e-220	xerC	-	-	L	ko:K03733,ko:K04763	-	ko00000,ko03036	tyrosine recombinase XerC
MDDHOLLC_02726	7.38e-121	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MDDHOLLC_02727	1.21e-86	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MDDHOLLC_02728	1.19e-212	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MDDHOLLC_02729	2.77e-175	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MDDHOLLC_02730	2.8e-84	flgB	-	-	N	ko:K02387	ko02040,map02040	ko00000,ko00001,ko02035	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
MDDHOLLC_02731	2.63e-99	flgC	-	-	N	ko:K02388	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the flagella basal body rod proteins family
MDDHOLLC_02732	1.51e-50	fliE	-	-	N	ko:K02408	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-basal body
MDDHOLLC_02733	0.0	fliF	-	-	N	ko:K02409	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	The M ring may be actively involved in energy transduction
MDDHOLLC_02734	2.48e-229	fliG	-	-	N	ko:K02410	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MDDHOLLC_02735	2.66e-120	fliH	-	-	NU	ko:K02411	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	COG1317 Flagellar biosynthesis type III secretory pathway protein
MDDHOLLC_02736	2.47e-307	fliI	3.6.3.14	-	NU	ko:K02412	ko02040,map02040	ko00000,ko00001,ko01000,ko02035,ko02044	COG1157 Flagellar biosynthesis type III secretory pathway ATPase
MDDHOLLC_02737	2.17e-92	fliJ	-	-	N	ko:K02413	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar biosynthesis chaperone
MDDHOLLC_02738	1.98e-88	ylxF	-	-	S	-	-	-	MgtE intracellular N domain
MDDHOLLC_02739	3e-260	fliK	-	-	N	ko:K02414	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-length control protein
MDDHOLLC_02740	1.8e-95	flgD	-	-	N	ko:K02389	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod modification protein
MDDHOLLC_02741	4.62e-178	flgG	-	-	N	ko:K02390	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod
MDDHOLLC_02742	1.85e-44	flbD	-	-	N	ko:K02385	-	ko00000,ko02035	protein, possibly involved in motility
MDDHOLLC_02743	6.59e-81	fliL	-	-	N	ko:K02415	-	ko00000,ko02035	Controls the rotational direction of flagella during chemotaxis
MDDHOLLC_02744	5.43e-230	fliM	-	-	N	ko:K02416	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MDDHOLLC_02745	6.97e-247	fliY	-	-	N	ko:K02417	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035,ko02044	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MDDHOLLC_02746	2.12e-77	cheY	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	response regulator
MDDHOLLC_02747	9.34e-144	fliZ	-	-	N	ko:K02418	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthesis protein, FliO
MDDHOLLC_02748	8.55e-142	fliP	-	-	N	ko:K02419	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Plays a role in the flagellum-specific transport system
MDDHOLLC_02749	3.15e-51	fliQ	-	-	N	ko:K02420	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Role in flagellar biosynthesis
MDDHOLLC_02750	5.74e-168	fliR	-	-	N	ko:K02421	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthetic protein FliR
MDDHOLLC_02751	1.03e-241	flhB	-	-	N	ko:K02401	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MDDHOLLC_02752	0.0	flhA	-	-	N	ko:K02400	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MDDHOLLC_02753	1.79e-246	flhF	-	-	N	ko:K02404	-	ko00000,ko02035	Flagellar biosynthesis regulator FlhF
MDDHOLLC_02754	8.79e-167	ylxH	-	-	D	ko:K04562	-	ko00000,ko02035	Belongs to the ParA family
MDDHOLLC_02755	6.77e-247	cheB	3.1.1.61, 3.5.1.44	-	NT	ko:K03412	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MDDHOLLC_02756	0.0	cheA	2.7.13.3	-	NT	ko:K03407	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	COG0643 Chemotaxis protein histidine kinase and related kinases
MDDHOLLC_02757	2.49e-105	cheW	-	-	NT	ko:K03408	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	COG0835 Chemotaxis signal transduction protein
MDDHOLLC_02758	3.42e-142	cheC	-	-	NT	ko:K03410	ko02030,map02030	ko00000,ko00001,ko02035	COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
MDDHOLLC_02759	2.86e-113	cheD	3.5.1.44	-	NT	ko:K03411	ko02030,map02030	ko00000,ko00001,ko01000,ko02035	Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
MDDHOLLC_02760	3.96e-177	sigD	-	-	K	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_02761	3.52e-91	ylxL	-	-	-	-	-	-	-
MDDHOLLC_02762	1.74e-167	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
MDDHOLLC_02763	1.34e-199	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MDDHOLLC_02764	7.09e-164	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
MDDHOLLC_02765	7.16e-73	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MDDHOLLC_02766	2.22e-186	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MDDHOLLC_02767	2.2e-178	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
MDDHOLLC_02768	2.2e-273	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MDDHOLLC_02769	4.66e-296	rasP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
MDDHOLLC_02770	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MDDHOLLC_02771	5.92e-186	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDDHOLLC_02772	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDDHOLLC_02773	9.4e-105	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
MDDHOLLC_02774	4.04e-264	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
MDDHOLLC_02775	6.16e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
MDDHOLLC_02776	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MDDHOLLC_02777	3.88e-60	ylxP	-	-	S	ko:K09764	-	ko00000	protein conserved in bacteria
MDDHOLLC_02778	1.03e-73	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MDDHOLLC_02779	7.05e-219	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MDDHOLLC_02780	3.69e-232	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
MDDHOLLC_02781	4.12e-56	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MDDHOLLC_02782	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MDDHOLLC_02783	8.37e-56	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
MDDHOLLC_02784	2.65e-134	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
MDDHOLLC_02785	2.41e-298	mlpA	-	-	S	-	-	-	Belongs to the peptidase M16 family
MDDHOLLC_02786	2.17e-56	ymxH	-	-	S	-	-	-	YlmC YmxH family
MDDHOLLC_02787	2.03e-203	dpaA	-	-	CH	ko:K06410	-	ko00000	Dipicolinate synthase subunit A
MDDHOLLC_02788	1.93e-137	spoVFB	-	-	H	ko:K06411	-	ko00000	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
MDDHOLLC_02789	4.09e-248	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MDDHOLLC_02790	2e-282	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MDDHOLLC_02791	7.2e-202	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MDDHOLLC_02792	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MDDHOLLC_02793	2.27e-166	tepA	-	-	OU	-	-	-	COG0740 Protease subunit of ATP-dependent Clp proteases
MDDHOLLC_02794	6.32e-42	-	-	-	S	-	-	-	YlzJ-like protein
MDDHOLLC_02795	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
MDDHOLLC_02796	1.06e-170	ymfC	-	-	K	ko:K03710	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_02797	3.77e-290	ymfD	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_02798	9.88e-100	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_02799	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	drug exporters of the RND superfamily
MDDHOLLC_02800	2.23e-298	ymfH	-	-	S	-	-	-	zinc protease
MDDHOLLC_02801	5.82e-164	ymfI	1.1.1.100	-	S	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
MDDHOLLC_02802	6.23e-56	ymfJ	-	-	S	-	-	-	Protein of unknown function (DUF3243)
MDDHOLLC_02803	3.14e-183	ymfK	-	-	S	-	-	-	Protein of unknown function (DUF3388)
MDDHOLLC_02804	2.34e-176	ymfM	-	-	S	ko:K15539	-	ko00000	protein conserved in bacteria
MDDHOLLC_02805	1.36e-131	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MDDHOLLC_02806	1.55e-292	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
MDDHOLLC_02807	3.06e-239	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MDDHOLLC_02808	2.22e-278	pbpX	-	-	V	-	-	-	Beta-lactamase
MDDHOLLC_02809	2.91e-308	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
MDDHOLLC_02810	6.42e-99	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
MDDHOLLC_02811	9.79e-60	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
MDDHOLLC_02812	2.44e-49	spoVS	-	-	S	ko:K06416	-	ko00000	Stage V sporulation protein S
MDDHOLLC_02813	6.82e-250	tdh	1.1.1.103	-	C	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
MDDHOLLC_02814	5e-274	kbl	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MDDHOLLC_02815	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MDDHOLLC_02816	2.11e-88	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
MDDHOLLC_02817	7.09e-119	cotE	-	-	S	ko:K06328	-	ko00000	Spore coat protein
MDDHOLLC_02818	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MDDHOLLC_02819	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MDDHOLLC_02821	4.05e-166	pksB	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	Polyketide biosynthesis
MDDHOLLC_02822	1.95e-82	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02823	4.68e-109	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02824	2.6e-233	pksD	-	-	Q	ko:K15328	-	ko00000,ko01008	Acyl transferase domain
MDDHOLLC_02825	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02826	1.46e-46	acpK	-	-	IQ	ko:K15337	-	ko00000,ko01008	Phosphopantetheine attachment site
MDDHOLLC_02827	7.03e-307	pksG	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
MDDHOLLC_02828	1.76e-186	-	-	-	I	ko:K15312	-	ko00000,ko01008	enoyl-CoA hydratase
MDDHOLLC_02829	3.42e-180	pksI	-	-	I	ko:K15313	-	ko00000,ko01008	Belongs to the enoyl-CoA hydratase isomerase family
MDDHOLLC_02830	0.0	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MDDHOLLC_02831	0.0	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MDDHOLLC_02832	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02833	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02834	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_02835	0.0	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MDDHOLLC_02836	3.83e-151	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MDDHOLLC_02837	0.0	-	-	-	HQ	ko:K13615	-	ko00000,ko01004,ko01008	Beta-ketoacyl synthase
MDDHOLLC_02838	6.55e-292	cypA	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MDDHOLLC_02839	1.74e-101	nucB	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
MDDHOLLC_02840	1.28e-152	yoaK	-	-	S	-	-	-	Membrane
MDDHOLLC_02841	7.97e-82	ymzB	-	-	-	-	-	-	-
MDDHOLLC_02842	0.0	aprX	-	-	O	ko:K17734	-	ko00000,ko01000,ko01002	Belongs to the peptidase S8 family
MDDHOLLC_02843	2.68e-161	ymaC	-	-	S	-	-	-	Replication protein
MDDHOLLC_02844	6.34e-85	ymaD	-	-	O	-	-	-	redox protein, regulator of disulfide bond formation
MDDHOLLC_02845	3.04e-71	ebrB	-	-	P	ko:K03297,ko:K11814,ko:K11815	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MDDHOLLC_02846	1.5e-62	ebrA	-	-	P	ko:K11814	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MDDHOLLC_02848	1.35e-73	ymaF	-	-	S	-	-	-	YmaF family
MDDHOLLC_02849	8.91e-220	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MDDHOLLC_02850	9e-46	hfq	-	-	J	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	ko00000,ko00001,ko03019,ko03036	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
MDDHOLLC_02851	4.76e-56	-	-	-	-	-	-	-	-
MDDHOLLC_02852	9.42e-29	ymzA	-	-	-	-	-	-	-
MDDHOLLC_02853	9.34e-88	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
MDDHOLLC_02854	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDDHOLLC_02855	6.19e-239	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDDHOLLC_02856	1.84e-140	ymaB	-	-	S	-	-	-	MutT family
MDDHOLLC_02857	8.82e-148	cwlC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MDDHOLLC_02858	1.55e-226	spoVK	-	-	O	ko:K06413	-	ko00000	stage V sporulation protein K
MDDHOLLC_02859	2.7e-295	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MDDHOLLC_02860	4.1e-311	ynbB	-	-	P	-	-	-	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
MDDHOLLC_02861	5.34e-89	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	transcriptional
MDDHOLLC_02862	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
MDDHOLLC_02863	1.43e-121	-	-	-	-	-	-	-	-
MDDHOLLC_02867	4.94e-54	-	-	-	S	-	-	-	Protein of unknown function (DUF2568)
MDDHOLLC_02868	3.42e-09	-	-	-	D	-	-	-	nuclear chromosome segregation
MDDHOLLC_02869	6.98e-265	mrjp	-	-	G	-	-	-	Major royal jelly protein
MDDHOLLC_02870	1.8e-316	xynP	-	-	G	ko:K03292	-	ko00000	MFS/sugar transport protein
MDDHOLLC_02871	0.0	xynB	3.2.1.37	GH43	G	ko:K01198	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
MDDHOLLC_02872	3.32e-264	xylR	-	-	GK	-	-	-	ROK family
MDDHOLLC_02873	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
MDDHOLLC_02874	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	xylulose kinase
MDDHOLLC_02875	0.0	pps	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
MDDHOLLC_02878	2.31e-234	adhP	1.1.1.1	-	C	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
MDDHOLLC_02881	1.98e-181	yoaP	-	-	K	-	-	-	YoaP-like
MDDHOLLC_02882	3.99e-129	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_02883	9.84e-108	-	-	-	S	-	-	-	Domain of unknown function (DUF3885)
MDDHOLLC_02884	2.49e-207	-	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MDDHOLLC_02885	9.55e-152	-	-	AA10,CBM73	S	ko:K03933	-	ko00000	Pfam:Chitin_bind_3
MDDHOLLC_02886	9.28e-07	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
MDDHOLLC_02887	1.76e-122	yvgO	-	-	-	-	-	-	-
MDDHOLLC_02889	0.0	yobO	-	-	M	-	-	-	Pectate lyase superfamily protein
MDDHOLLC_02890	1.74e-101	yncF	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Deoxyuridine 5'-triphosphate
MDDHOLLC_02891	1.47e-177	yndL	-	-	S	-	-	-	Replication protein
MDDHOLLC_02892	8.63e-12	-	-	-	-	-	-	-	-
MDDHOLLC_02893	2.01e-85	-	-	-	O	-	-	-	COG0330 Membrane protease subunits, stomatin prohibitin homologs
MDDHOLLC_02894	1e-58	-	-	-	O	-	-	-	COG0330 Membrane protease subunits, stomatin prohibitin homologs
MDDHOLLC_02895	7.53e-94	yndM	-	-	S	-	-	-	Protein of unknown function (DUF2512)
MDDHOLLC_02897	3.18e-141	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MDDHOLLC_02898	1.01e-67	yneA	-	-	D	-	-	-	Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
MDDHOLLC_02899	5.22e-145	yneB	-	-	L	-	-	-	resolvase
MDDHOLLC_02900	2.33e-43	ynzC	-	-	S	-	-	-	UPF0291 protein
MDDHOLLC_02901	5.57e-162	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MDDHOLLC_02902	3.69e-302	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MDDHOLLC_02903	5.14e-105	yneE	-	-	S	-	-	-	Sporulation inhibitor of replication protein sirA
MDDHOLLC_02904	6.2e-39	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
MDDHOLLC_02905	1.97e-33	ynzD	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
MDDHOLLC_02906	4.47e-164	ccdA	-	-	O	ko:K06196	-	ko00000,ko02000	cytochrome c biogenesis protein
MDDHOLLC_02907	1.43e-75	ccdB	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
MDDHOLLC_02908	7.59e-97	yneJ	-	-	O	-	-	-	COG4846 Membrane protein involved in cytochrome C biogenesis
MDDHOLLC_02909	1.97e-97	yneK	-	-	S	-	-	-	Protein of unknown function (DUF2621)
MDDHOLLC_02910	2.44e-82	cotM	-	-	O	ko:K06335	-	ko00000	Spore coat protein
MDDHOLLC_02911	1.97e-27	sspP	-	-	S	ko:K06433	-	ko00000	Belongs to the SspP family
MDDHOLLC_02912	6.2e-22	sspO	-	-	S	ko:K06432	-	ko00000	Belongs to the SspO family
MDDHOLLC_02913	0.0	citB	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MDDHOLLC_02914	9.94e-120	yneN	-	-	CO	-	-	-	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MDDHOLLC_02915	6.28e-09	-	-	-	S	-	-	-	Fur-regulated basic protein B
MDDHOLLC_02917	1e-43	tlp	-	-	S	ko:K06434	-	ko00000	Belongs to the Tlp family
MDDHOLLC_02918	2.94e-97	yneP	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
MDDHOLLC_02919	1.29e-68	yneQ	-	-	-	-	-	-	-
MDDHOLLC_02920	3.13e-65	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
MDDHOLLC_02921	7.46e-120	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MDDHOLLC_02922	9.94e-90	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
MDDHOLLC_02923	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MDDHOLLC_02924	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MDDHOLLC_02925	3.14e-19	-	-	-	-	-	-	-	-
MDDHOLLC_02926	1.82e-63	ynfC	-	-	-	-	-	-	-
MDDHOLLC_02927	0.0	alsT	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
MDDHOLLC_02928	4.3e-229	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
MDDHOLLC_02929	3.46e-241	yjmD	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
MDDHOLLC_02930	1.84e-147	kdgA	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	2-dehydro-3-deoxy-phosphogluconate aldolase
MDDHOLLC_02931	7.34e-267	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
MDDHOLLC_02932	3.96e-189	yjmF	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_02933	4.82e-229	regR	-	-	K	ko:K02525	-	ko00000,ko03000	transcriptional
MDDHOLLC_02934	4.18e-282	exuT	-	-	G	ko:K08191,ko:K08194	-	ko00000,ko02000	Sugar (and other) transporter
MDDHOLLC_02935	3.31e-198	yndG	-	-	S	-	-	-	DoxX-like family
MDDHOLLC_02936	1.65e-101	-	-	-	S	-	-	-	Domain of unknown function (DUF4166)
MDDHOLLC_02937	0.0	yndJ	-	-	S	-	-	-	YndJ-like protein
MDDHOLLC_02938	1.93e-125	-	-	-	S	-	-	-	MTH538 TIR-like domain (DUF1863)
MDDHOLLC_02939	1.13e-172	-	-	-	T	-	-	-	intracellular signal transduction
MDDHOLLC_02940	0.0	bglC5	3.2.1.4	GH5,GH9	G	ko:K01179	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	PFAM glycoside hydrolase family 5
MDDHOLLC_02941	2.03e-67	yvlA	-	-	S	-	-	-	Domain of unknown function (DUF4870)
MDDHOLLC_02942	7.03e-305	-	-	-	T	-	-	-	Histidine kinase
MDDHOLLC_02943	4.23e-161	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
MDDHOLLC_02944	1.05e-314	ynfF	3.2.1.136	GH5	G	ko:K15924	-	ko00000,ko01000	Glycosyl hydrolase family 30 beta sandwich domain
MDDHOLLC_02945	0.0	xynD	3.2.1.55	CBM6,GH43	G	ko:K15921	ko00520,map00520	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
MDDHOLLC_02946	1.36e-304	-	-	-	Q	ko:K15662,ko:K15663	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02947	0.0	-	-	-	Q	ko:K15662,ko:K15663	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02948	0.0	-	-	-	Q	ko:K15662,ko:K15663	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02949	0.0	nrsA	-	-	Q	ko:K15661	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02950	2.22e-277	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_02951	3.23e-175	yxjF	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MDDHOLLC_02952	1.06e-155	scoB	2.8.3.5	-	I	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MDDHOLLC_02953	8.91e-162	scoA	2.8.3.5	-	I	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MDDHOLLC_02954	0.0	yxjC	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
MDDHOLLC_02955	1.82e-275	bioI	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MDDHOLLC_02956	1.12e-246	bioB	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MDDHOLLC_02957	1.19e-163	bioD	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MDDHOLLC_02958	1.54e-270	bioF	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MDDHOLLC_02959	0.0	bioA	2.6.1.105, 2.6.1.62	-	H	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
MDDHOLLC_02960	5.24e-183	bioW	6.2.1.14	-	H	ko:K01906	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MDDHOLLC_02961	4.92e-90	yngA	-	-	S	-	-	-	membrane
MDDHOLLC_02962	8.07e-203	yngB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
MDDHOLLC_02963	5.33e-135	yngC	-	-	S	-	-	-	SNARE associated Golgi protein
MDDHOLLC_02964	0.0	yngE	-	-	I	-	-	-	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MDDHOLLC_02965	4.1e-177	yngF	-	-	I	-	-	-	Belongs to the enoyl-CoA hydratase isomerase family
MDDHOLLC_02966	5.77e-213	yngG	4.1.3.4	-	E	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA lyase
MDDHOLLC_02967	2.77e-41	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin carboxyl carrier protein
MDDHOLLC_02968	0.0	yngH	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase
MDDHOLLC_02969	0.0	yngI	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MDDHOLLC_02970	3.61e-266	yngJ	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
MDDHOLLC_02971	0.0	yngK	-	-	T	-	-	-	Glycosyl hydrolase-like 10
MDDHOLLC_02972	1.38e-84	yngL	-	-	S	-	-	-	Protein of unknown function (DUF1360)
MDDHOLLC_02973	0.0	-	-	-	Q	ko:K15656,ko:K15668	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	D-alanine [D-alanyl carrier protein] ligase activity
MDDHOLLC_02974	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02975	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02976	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02977	0.0	-	-	-	Q	ko:K15665	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02978	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_02979	0.0	dacC	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
MDDHOLLC_02980	5.3e-237	yoxA	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
MDDHOLLC_02981	1.75e-310	yoeA	-	-	V	-	-	-	MATE efflux family protein
MDDHOLLC_02982	1e-09	yoeB	-	-	S	-	-	-	IseA DL-endopeptidase inhibitor
MDDHOLLC_02983	2.85e-91	yoeB	-	-	S	-	-	-	IseA DL-endopeptidase inhibitor
MDDHOLLC_02984	3.33e-249	-	-	-	S	-	-	-	Bacterial EndoU nuclease
MDDHOLLC_02985	4.77e-33	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
MDDHOLLC_02986	3.6e-13	-	-	-	L	-	-	-	Membrane
MDDHOLLC_02987	5.89e-87	xlyA	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	n-acetylmuramoyl-L-alanine amidase
MDDHOLLC_02988	1.92e-42	xhlB	-	-	S	-	-	-	SPP1 phage holin
MDDHOLLC_02989	6.31e-38	bhlA	-	-	S	-	-	-	BhlA holin family
MDDHOLLC_02992	1.27e-141	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
MDDHOLLC_02993	6.86e-28	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
MDDHOLLC_02994	0.0	-	-	-	M	-	-	-	Pectate lyase superfamily protein
MDDHOLLC_02995	5.63e-289	acm2	3.2.1.17	-	NU	ko:K01185	-	ko00000,ko01000	Prophage endopeptidase tail
MDDHOLLC_02996	4.6e-133	-	-	-	S	-	-	-	Phage tail protein
MDDHOLLC_02997	0.0	-	-	-	D	-	-	-	phage tail tape measure protein
MDDHOLLC_02998	2.45e-05	-	-	-	-	-	-	-	-
MDDHOLLC_02999	7.89e-100	-	-	-	S	-	-	-	Phage tail tube protein
MDDHOLLC_03001	1.14e-64	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
MDDHOLLC_03002	4.85e-55	-	-	-	S	-	-	-	Phage head-tail joining protein
MDDHOLLC_03003	2.51e-53	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
MDDHOLLC_03004	2.8e-34	-	-	-	-	-	-	-	-
MDDHOLLC_03005	6.09e-196	-	-	-	S	-	-	-	capsid protein
MDDHOLLC_03006	1.43e-104	-	-	-	S	-	-	-	peptidase activity
MDDHOLLC_03007	5.49e-213	-	-	-	S	-	-	-	Phage portal protein
MDDHOLLC_03008	0.0	-	-	-	S	-	-	-	Terminase
MDDHOLLC_03009	7.37e-102	-	-	-	L	-	-	-	phage terminase small subunit
MDDHOLLC_03010	5.65e-65	-	-	-	V	ko:K07451	-	ko00000,ko01000,ko02048	HNH endonuclease
MDDHOLLC_03011	1.23e-54	-	-	-	S	-	-	-	SEC-C motif
MDDHOLLC_03012	2.78e-61	-	-	-	F	-	-	-	nucleoside 2-deoxyribosyltransferase
MDDHOLLC_03013	2.06e-31	-	-	-	L	-	-	-	Integrase
MDDHOLLC_03014	2.44e-45	-	-	-	L	-	-	-	Phage integrase family
MDDHOLLC_03015	4.77e-69	-	-	-	M	-	-	-	ArpU family transcriptional regulator
MDDHOLLC_03016	4.57e-07	-	-	-	-	-	-	-	-
MDDHOLLC_03018	2.63e-107	-	-	-	V	-	-	-	restriction endodeoxyribonuclease activity
MDDHOLLC_03019	8.35e-57	-	-	-	-	-	-	-	-
MDDHOLLC_03023	9.19e-21	yqaO	-	-	S	-	-	-	Phage-like element PBSX protein XtrA
MDDHOLLC_03026	2.06e-34	-	-	-	-	-	-	-	-
MDDHOLLC_03028	2.35e-59	-	-	-	L	ko:K02315,ko:K11144	-	ko00000,ko03032	DNA replication protein
MDDHOLLC_03029	9.47e-61	-	-	-	S	-	-	-	N-terminal phage replisome organiser (Phage_rep_org_N)
MDDHOLLC_03031	4.51e-50	-	-	-	S	-	-	-	Domain of unknown function (DUF771)
MDDHOLLC_03032	2.6e-06	ahdIC	-	-	K	-	-	-	PFAM helix-turn-helix domain protein
MDDHOLLC_03033	3.44e-38	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MDDHOLLC_03036	1.23e-91	-	-	-	-	-	-	-	-
MDDHOLLC_03037	1.02e-146	-	-	-	L	-	-	-	Phage integrase family
MDDHOLLC_03039	3.97e-125	-	-	-	L	-	-	-	Integrase
MDDHOLLC_03040	6.69e-47	yoeD	-	-	G	-	-	-	Helix-turn-helix domain
MDDHOLLC_03041	0.0	ggt	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
MDDHOLLC_03042	5.14e-226	-	-	-	EGP	ko:K08164	-	ko00000,ko02000	-transporter
MDDHOLLC_03043	3.29e-67	-	-	-	K	-	-	-	Helix-turn-helix domain
MDDHOLLC_03044	4.79e-17	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MDDHOLLC_03045	8.7e-198	gltR1	-	-	K	ko:K21959	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03046	3.16e-233	yogA	-	-	C	ko:K13955	-	ko00000	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MDDHOLLC_03047	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
MDDHOLLC_03048	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase
MDDHOLLC_03049	6.93e-204	gltC	-	-	K	ko:K09681	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03050	2.31e-258	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MDDHOLLC_03051	3.42e-181	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MDDHOLLC_03052	8.08e-79	rtp	-	-	K	-	-	-	Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
MDDHOLLC_03053	2.43e-157	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_03054	7.75e-53	-	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MDDHOLLC_03055	3.4e-38	yoxB	-	-	-	-	-	-	-
MDDHOLLC_03056	7.07e-120	yoxB	-	-	-	-	-	-	-
MDDHOLLC_03057	4.46e-261	yoaB	-	-	EGP	-	-	-	the major facilitator superfamily
MDDHOLLC_03058	0.0	lsrK	2.7.1.189	-	G	ko:K11216	ko02024,map02024	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
MDDHOLLC_03059	1.04e-246	yoaD	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MDDHOLLC_03060	1.2e-84	yoaE	-	-	C	-	-	-	belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MDDHOLLC_03061	0.0	yoaE	-	-	C	-	-	-	belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MDDHOLLC_03064	2.13e-124	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_03065	5.71e-58	-	-	-	-	-	-	-	-
MDDHOLLC_03066	4.97e-168	ykvO	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MDDHOLLC_03067	5.86e-80	ykvN	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03068	8.66e-70	csaA	-	-	J	ko:K06878	-	ko00000	tRNA-binding protein
MDDHOLLC_03069	1.45e-170	yobQ	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
MDDHOLLC_03070	1.35e-119	yobS	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03071	8.82e-162	yobT	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MDDHOLLC_03072	1.57e-118	yobW	-	-	-	-	-	-	-
MDDHOLLC_03073	1.72e-54	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	transcriptional
MDDHOLLC_03074	1.19e-157	yocA	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MDDHOLLC_03075	1.33e-117	yozB	-	-	S	ko:K08976	-	ko00000	membrane
MDDHOLLC_03076	2.98e-102	-	-	-	J	-	-	-	Protein required for attachment to host cells
MDDHOLLC_03077	4.89e-55	-	-	-	J	-	-	-	Protein required for attachment to host cells
MDDHOLLC_03078	3.78e-122	yocC	-	-	-	-	-	-	-
MDDHOLLC_03079	6.44e-239	yocD	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	peptidase S66
MDDHOLLC_03081	1.46e-160	yocH	-	-	M	-	-	-	COG1388 FOG LysM repeat
MDDHOLLC_03082	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_03083	8.68e-19	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_03084	2.32e-144	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MDDHOLLC_03086	2.23e-79	yocK	-	-	T	-	-	-	general stress protein
MDDHOLLC_03087	2.71e-13	yocL	-	-	-	-	-	-	-
MDDHOLLC_03089	2.29e-116	yocM	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MDDHOLLC_03090	9.63e-60	yozN	-	-	-	-	-	-	-
MDDHOLLC_03091	6.36e-50	yocN	-	-	-	-	-	-	-
MDDHOLLC_03092	5.32e-75	yozO	-	-	S	-	-	-	Bacterial PH domain
MDDHOLLC_03094	1.11e-41	yozC	-	-	-	-	-	-	-
MDDHOLLC_03095	0.0	dhaS	1.2.1.3, 1.2.1.39	-	C	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MDDHOLLC_03096	0.0	sqhC	4.2.1.137	-	I	ko:K18115	-	ko00000,ko01000	COG1657 Squalene cyclase
MDDHOLLC_03097	9.6e-212	sodF	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Superoxide dismutase
MDDHOLLC_03098	9.83e-188	yocR	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MDDHOLLC_03099	2.62e-65	yocR	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MDDHOLLC_03100	1.29e-212	yocS	-	-	S	ko:K03453	-	ko00000	-transporter
MDDHOLLC_03101	1.44e-176	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
MDDHOLLC_03102	3.01e-262	odhB	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
MDDHOLLC_03103	0.0	odhA	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
MDDHOLLC_03104	0.0	yojO	-	-	P	-	-	-	Von Willebrand factor
MDDHOLLC_03105	3.52e-48	yojN	-	-	S	ko:K04748	-	ko00000	ATPase family associated with various cellular activities (AAA)
MDDHOLLC_03106	3.65e-134	yojN	-	-	S	ko:K04748	-	ko00000	ATPase family associated with various cellular activities (AAA)
MDDHOLLC_03107	8.73e-98	sodC	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MDDHOLLC_03108	1.12e-28	sodC	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MDDHOLLC_03109	8.28e-291	-	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MDDHOLLC_03110	4.53e-283	-	-	-	CG	-	-	-	UDP-glucoronosyl and UDP-glucosyl transferase
MDDHOLLC_03111	4.69e-144	dacB	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MDDHOLLC_03113	1.16e-301	norM	-	-	V	ko:K03327	-	ko00000,ko02000	Multidrug efflux pump
MDDHOLLC_03114	5.03e-194	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MDDHOLLC_03115	2.24e-162	yojG	-	-	S	ko:K22135	-	ko00000,ko01000	deacetylase
MDDHOLLC_03116	3.3e-79	yojF	-	-	S	-	-	-	Protein of unknown function (DUF1806)
MDDHOLLC_03117	1.05e-30	-	-	-	-	-	-	-	-
MDDHOLLC_03118	5.73e-208	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	-transporter
MDDHOLLC_03119	1.91e-103	yozR	-	-	S	-	-	-	COG0071 Molecular chaperone (small heat shock protein)
MDDHOLLC_03121	3.67e-89	iolK	-	-	S	-	-	-	tautomerase
MDDHOLLC_03122	3.09e-89	yoaQ	-	-	S	-	-	-	Evidence 4 Homologs of previously reported genes of
MDDHOLLC_03123	2.42e-74	yodB	-	-	K	-	-	-	transcriptional
MDDHOLLC_03124	1.35e-138	yodC	-	-	C	-	-	-	nitroreductase
MDDHOLLC_03125	2.84e-139	yahD	-	-	S	ko:K06999	-	ko00000	Carboxylesterase
MDDHOLLC_03126	1.8e-220	yodE	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MDDHOLLC_03127	1.97e-28	-	-	-	S	-	-	-	Protein of unknown function (DUF3311)
MDDHOLLC_03128	0.0	yodF	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MDDHOLLC_03129	0.0	-	3.2.1.45	GH30	M	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	ko00000,ko00001,ko01000	Glycosyl hydrolase family 30 beta sandwich domain
MDDHOLLC_03130	3.34e-274	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MDDHOLLC_03131	2.15e-74	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MDDHOLLC_03132	1.69e-135	yydK	-	-	K	ko:K03489	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03133	0.0	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
MDDHOLLC_03134	2.91e-164	yodH	-	-	Q	-	-	-	Methyltransferase
MDDHOLLC_03135	2.5e-32	yodI	-	-	-	-	-	-	-
MDDHOLLC_03136	4.49e-192	yodJ	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
MDDHOLLC_03137	1.05e-161	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
MDDHOLLC_03139	1.16e-72	yodL	-	-	S	-	-	-	YodL-like
MDDHOLLC_03140	1.54e-131	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
MDDHOLLC_03141	9.77e-34	yozD	-	-	S	-	-	-	YozD-like protein
MDDHOLLC_03143	1.9e-161	yodN	-	-	-	-	-	-	-
MDDHOLLC_03144	1.36e-33	-	-	-	E	-	-	-	lactoylglutathione lyase activity
MDDHOLLC_03145	1e-47	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
MDDHOLLC_03146	2.83e-62	yokU	-	-	S	-	-	-	YokU-like protein, putative antitoxin
MDDHOLLC_03147	0.0	kamA	5.4.3.2	-	E	ko:K01843	ko00310,map00310	ko00000,ko00001,ko01000	lysine 2,3-aminomutase
MDDHOLLC_03148	3.7e-199	yodP	2.3.1.264	-	K	ko:K21935	-	ko00000,ko01000	Acetyltransferase (GNAT) family
MDDHOLLC_03149	2.19e-314	yodQ	3.5.1.16, 3.5.1.18	-	E	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetylornithine deacetylase
MDDHOLLC_03150	4.64e-160	atoA	2.8.3.8, 2.8.3.9	-	I	ko:K01035	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MDDHOLLC_03151	3.98e-160	atoD	2.8.3.8, 2.8.3.9	-	I	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MDDHOLLC_03152	1.27e-307	yodT	-	-	H	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MDDHOLLC_03153	8.35e-84	-	-	-	L	-	-	-	Bacterial transcription activator, effector binding domain
MDDHOLLC_03155	4.34e-85	yiiD	-	-	K	ko:K06323	-	ko00000	acetyltransferase
MDDHOLLC_03156	5.72e-81	yiiD	-	-	K	ko:K06323	-	ko00000	acetyltransferase
MDDHOLLC_03157	6.26e-307	cgeD	-	-	M	ko:K06322	-	ko00000	maturation of the outermost layer of the spore
MDDHOLLC_03158	7.84e-61	cgeC	-	-	-	ko:K06321	-	ko00000	-
MDDHOLLC_03159	1.22e-87	cgeA	-	-	-	ko:K06319	-	ko00000	-
MDDHOLLC_03160	5.02e-228	cgeB	-	-	S	ko:K06320	-	ko00000	Spore maturation protein
MDDHOLLC_03161	5.04e-279	phy	3.1.3.8	-	I	ko:K01083	ko00562,map00562	ko00000,ko00001,ko01000	Myo-inositol-hexaphosphate 3-phosphohydrolase
MDDHOLLC_03162	3.54e-95	-	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MDDHOLLC_03168	3.1e-100	-	-	-	-	-	-	-	-
MDDHOLLC_03169	3.03e-25	ligB	6.5.1.1, 6.5.1.6, 6.5.1.7	-	L	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	ko00000,ko00001,ko01000,ko03032,ko03400	ATP-dependent DNA ligase
MDDHOLLC_03173	7.54e-99	yoqH	-	-	M	-	-	-	LysM domain
MDDHOLLC_03174	6.23e-266	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MDDHOLLC_03177	3.26e-214	-	-	-	S	-	-	-	amine dehydrogenase activity
MDDHOLLC_03181	6.25e-38	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_03182	2.12e-111	yokK	-	-	S	-	-	-	SMI1 / KNR4 family
MDDHOLLC_03183	3.88e-68	-	-	-	S	ko:K21488	-	ko00000,ko02048	SMI1-KNR4 cell-wall
MDDHOLLC_03184	0.0	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MDDHOLLC_03185	2.98e-116	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
MDDHOLLC_03187	0.0	yokA	-	-	L	-	-	-	Recombinase
MDDHOLLC_03188	3.43e-134	-	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MDDHOLLC_03189	4.61e-106	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
MDDHOLLC_03190	1.2e-133	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDDHOLLC_03191	3.35e-89	ypoP	-	-	K	-	-	-	transcriptional
MDDHOLLC_03192	1.6e-125	ypmS	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_03193	1.43e-173	ypmR	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
MDDHOLLC_03194	2.71e-121	ypmQ	-	-	S	ko:K07152	-	ko00000,ko03029	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
MDDHOLLC_03195	2.48e-52	ypmP	-	-	S	-	-	-	Protein of unknown function (DUF2535)
MDDHOLLC_03196	1.73e-308	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MDDHOLLC_03197	1.59e-221	yplP	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03198	5.24e-143	yplQ	-	-	S	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
MDDHOLLC_03199	1.92e-147	ypkP	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MDDHOLLC_03200	5.2e-118	dfrA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MDDHOLLC_03201	2.09e-168	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MDDHOLLC_03202	2.17e-146	ypjP	-	-	S	-	-	-	YpjP-like protein
MDDHOLLC_03203	6.04e-173	ypiP	-	-	AJ	-	-	-	Putative SAM-dependent methyltransferase
MDDHOLLC_03204	5.56e-57	yphP	-	-	S	-	-	-	Belongs to the UPF0403 family
MDDHOLLC_03205	5.52e-249	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
MDDHOLLC_03206	2.25e-97	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
MDDHOLLC_03207	3.51e-200	ypgR	-	-	C	-	-	-	COG0694 Thioredoxin-like proteins and domains
MDDHOLLC_03208	3.97e-129	yagB	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
MDDHOLLC_03209	5.36e-111	bsaA	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
MDDHOLLC_03210	1.33e-226	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MDDHOLLC_03211	3.28e-223	ugtP	2.4.1.315	GT28	M	ko:K03429	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
MDDHOLLC_03212	5.12e-42	cspD	-	-	K	ko:K03704	-	ko00000,ko03000	Cold-shock protein
MDDHOLLC_03213	1.13e-49	-	-	-	S	-	-	-	Protein of unknown function (DUF2564)
MDDHOLLC_03214	6.59e-40	ypeQ	-	-	S	-	-	-	Zinc-finger
MDDHOLLC_03215	8.39e-159	ypeP	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	COG0328 Ribonuclease HI
MDDHOLLC_03216	2.2e-151	ypdP	-	-	S	ko:K09125	-	ko00000	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MDDHOLLC_03217	2.47e-88	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease
MDDHOLLC_03219	2.69e-156	ypcP	-	-	L	-	-	-	5'3' exonuclease
MDDHOLLC_03220	1.45e-20	ypcP	-	-	L	-	-	-	5'3' exonuclease
MDDHOLLC_03221	2.44e-10	-	-	-	-	-	-	-	-
MDDHOLLC_03222	1.17e-51	ypbS	-	-	S	-	-	-	Protein of unknown function (DUF2533)
MDDHOLLC_03223	0.0	ypbR	-	-	S	-	-	-	Dynamin family
MDDHOLLC_03224	5.14e-17	ypbR	-	-	S	-	-	-	Dynamin family
MDDHOLLC_03225	1.26e-117	ypbQ	-	-	S	ko:K16168	-	ko00000,ko01008	protein conserved in bacteria
MDDHOLLC_03226	9.52e-264	bcsA	-	-	Q	ko:K16167	-	ko00000,ko01008	Naringenin-chalcone synthase
MDDHOLLC_03227	1.77e-136	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_03228	1.17e-65	MGMT	-	-	L	ko:K07443	-	ko00000	6-O-methylguanine DNA methyltransferase, DNA binding domain
MDDHOLLC_03229	6.89e-08	-	-	-	S	-	-	-	Bacillus cereus group antimicrobial protein
MDDHOLLC_03230	1.78e-29	ydfR	-	-	S	-	-	-	Protein of unknown function (DUF421)
MDDHOLLC_03231	1.08e-73	ydfR	-	-	S	-	-	-	Protein of unknown function (DUF421)
MDDHOLLC_03232	2.46e-127	yrdC	-	-	Q	-	-	-	Isochorismatase family
MDDHOLLC_03233	4.67e-07	-	-	-	-	-	-	-	-
MDDHOLLC_03234	1.19e-296	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine
MDDHOLLC_03235	5.51e-127	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MDDHOLLC_03236	0.0	ypwA	3.4.17.19	-	E	ko:K01299	-	ko00000,ko01000,ko01002	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MDDHOLLC_03237	0.0	ypvA	3.6.4.12	-	KL	ko:K03722	-	ko00000,ko01000,ko03400	COG1199 Rad3-related DNA helicases
MDDHOLLC_03239	6.91e-31	-	-	-	S	-	-	-	YpzG-like protein
MDDHOLLC_03240	3.16e-274	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
MDDHOLLC_03241	5.52e-61	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MDDHOLLC_03242	1.82e-126	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
MDDHOLLC_03243	9.36e-48	cotD	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
MDDHOLLC_03245	2.45e-287	yprB	-	-	L	ko:K07502	-	ko00000	RNase_H superfamily
MDDHOLLC_03246	0.0	yprA	-	-	L	ko:K06877	-	ko00000	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
MDDHOLLC_03247	9.93e-115	ypqE	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
MDDHOLLC_03248	7.23e-93	hspX	-	-	O	ko:K06335,ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MDDHOLLC_03249	9.54e-81	yppG	-	-	S	-	-	-	YppG-like protein
MDDHOLLC_03253	0.000542	-	-	-	-	ko:K06430	-	ko00000	-
MDDHOLLC_03254	2e-239	yppC	-	-	S	-	-	-	Protein of unknown function (DUF2515)
MDDHOLLC_03255	7.27e-145	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MDDHOLLC_03256	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MDDHOLLC_03257	1.8e-119	ypoC	-	-	-	-	-	-	-
MDDHOLLC_03258	4e-155	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MDDHOLLC_03259	3.42e-167	dnaD	-	-	L	ko:K02086	-	ko00000	DNA replication protein DnaD
MDDHOLLC_03260	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	asparaginyl-tRNA
MDDHOLLC_03261	8.7e-111	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MDDHOLLC_03262	6.11e-148	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MDDHOLLC_03263	5.58e-104	ypmB	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_03264	1.52e-32	ypmA	-	-	S	-	-	-	Protein of unknown function (DUF4264)
MDDHOLLC_03265	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
MDDHOLLC_03266	2.41e-84	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MDDHOLLC_03267	5.47e-200	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MDDHOLLC_03268	2.21e-190	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MDDHOLLC_03269	3.15e-230	birA	6.3.4.15	-	K	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MDDHOLLC_03270	7.21e-281	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MDDHOLLC_03271	3.22e-184	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
MDDHOLLC_03272	5.8e-53	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
MDDHOLLC_03273	4.48e-170	bshB1	-	-	S	ko:K01463	-	ko00000,ko01000	proteins, LmbE homologs
MDDHOLLC_03274	7.23e-93	mgsA	4.2.3.3	-	G	ko:K01734	ko00640,ko01120,map00640,map01120	ko00000,ko00001,ko01000	methylglyoxal synthase
MDDHOLLC_03275	9.78e-189	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MDDHOLLC_03276	2.47e-74	ypjD	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
MDDHOLLC_03277	4.31e-199	ypjC	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_03278	4.06e-289	-	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
MDDHOLLC_03279	1.96e-180	ypjB	-	-	S	-	-	-	sporulation protein
MDDHOLLC_03280	2.17e-135	ypjA	-	-	S	-	-	-	membrane
MDDHOLLC_03281	2.33e-190	qcrC	-	-	C	ko:K03888	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	Menaquinol-cytochrome c reductase cytochrome b c subunit
MDDHOLLC_03282	1.16e-99	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
MDDHOLLC_03283	1.06e-46	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
MDDHOLLC_03284	2.86e-127	qcrA	-	-	C	ko:K03886	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Menaquinol-cytochrome c reductase
MDDHOLLC_03285	3.34e-101	ypiF	-	-	S	-	-	-	Protein of unknown function (DUF2487)
MDDHOLLC_03286	2.6e-129	ypiB	-	-	S	-	-	-	Belongs to the UPF0302 family
MDDHOLLC_03287	8.74e-298	ypiA	-	-	S	-	-	-	COG0457 FOG TPR repeat
MDDHOLLC_03288	1.03e-303	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MDDHOLLC_03289	1.39e-257	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
MDDHOLLC_03290	1.5e-257	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MDDHOLLC_03291	2.8e-187	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MDDHOLLC_03292	1.42e-289	trpB	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MDDHOLLC_03293	1.68e-146	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
MDDHOLLC_03294	2.36e-167	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
MDDHOLLC_03295	1.62e-175	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MDDHOLLC_03296	2.18e-15	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MDDHOLLC_03297	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MDDHOLLC_03298	6.92e-78	aroH	5.4.99.5	-	E	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
MDDHOLLC_03299	2.61e-259	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MDDHOLLC_03300	9.75e-276	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MDDHOLLC_03301	1.96e-178	cheR	2.1.1.80	-	NT	ko:K00575	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko01000,ko02035	COG1352 Methylase of chemotaxis methyl-accepting proteins
MDDHOLLC_03302	2.86e-102	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MDDHOLLC_03303	9.31e-251	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
MDDHOLLC_03304	7.76e-169	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MDDHOLLC_03305	3.96e-177	hepS	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
MDDHOLLC_03306	6.23e-47	mtrB	-	-	K	ko:K06285	-	ko00000,ko03000	Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
MDDHOLLC_03307	6.27e-131	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
MDDHOLLC_03308	1.07e-57	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MDDHOLLC_03309	0.0	spoIVA	-	-	S	ko:K06398	-	ko00000	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MDDHOLLC_03310	4.24e-168	yphF	-	-	-	-	-	-	-
MDDHOLLC_03311	3.25e-23	yphE	-	-	S	-	-	-	Protein of unknown function (DUF2768)
MDDHOLLC_03312	4.93e-244	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
MDDHOLLC_03313	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
MDDHOLLC_03314	1.46e-134	yphA	-	-	-	-	-	-	-
MDDHOLLC_03315	1.87e-12	-	-	-	S	-	-	-	YpzI-like protein
MDDHOLLC_03316	2.81e-236	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MDDHOLLC_03317	8.14e-264	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
MDDHOLLC_03318	2.02e-146	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
MDDHOLLC_03319	7.86e-18	-	-	-	S	-	-	-	Family of unknown function (DUF5359)
MDDHOLLC_03320	9.47e-77	ypfA	-	-	M	-	-	-	Flagellar protein YcgR
MDDHOLLC_03321	0.0	ypeB	-	-	H	ko:K06313	-	ko00000	sporulation protein
MDDHOLLC_03322	2.09e-210	sleB	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Spore cortex-lytic enzyme
MDDHOLLC_03323	6.4e-156	prsW	-	-	S	-	-	-	Involved in the degradation of specific anti-sigma factors
MDDHOLLC_03324	7.53e-239	ypdA	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	COG0492 Thioredoxin reductase
MDDHOLLC_03325	1.81e-311	gudB	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MDDHOLLC_03326	3.35e-137	mecB	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MDDHOLLC_03327	9.06e-187	ypbG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
MDDHOLLC_03328	1.92e-111	ypbF	-	-	S	-	-	-	Protein of unknown function (DUF2663)
MDDHOLLC_03329	1.04e-16	ypbE	-	-	M	-	-	-	Lysin motif
MDDHOLLC_03330	2.81e-84	ypbE	-	-	M	-	-	-	Lysin motif
MDDHOLLC_03331	1.4e-127	ypbD	-	-	S	ko:K07052	-	ko00000	metal-dependent membrane protease
MDDHOLLC_03332	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
MDDHOLLC_03333	5.36e-247	ypbB	5.1.3.1	-	S	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	protein conserved in bacteria
MDDHOLLC_03334	5.88e-55	fer	-	-	C	ko:K05337	-	ko00000	Ferredoxin
MDDHOLLC_03335	2.16e-122	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MDDHOLLC_03336	0.0	serA	1.1.1.399, 1.1.1.95	-	E	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MDDHOLLC_03337	5.3e-245	rsiX	-	-	-	-	-	-	-
MDDHOLLC_03338	3.22e-135	sigX	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MDDHOLLC_03339	0.0	resE	2.7.13.3	-	T	ko:K07651	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_03340	9.77e-171	resD	-	-	T	ko:K07775	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_03341	6.24e-252	resC	-	-	O	-	-	-	'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
MDDHOLLC_03342	0.0	resB	-	-	O	ko:K07399	-	ko00000	COG1333 ResB protein required for cytochrome c biosynthesis
MDDHOLLC_03343	4.31e-128	resA	-	-	CO	-	-	-	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
MDDHOLLC_03344	4.27e-167	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
MDDHOLLC_03345	8.99e-116	spmB	-	-	S	ko:K06374	-	ko00000	Spore maturation protein
MDDHOLLC_03346	3.75e-135	spmA	-	-	S	ko:K06373	-	ko00000	Spore maturation protein
MDDHOLLC_03347	1.14e-275	dacB	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MDDHOLLC_03348	6.14e-122	ypuI	-	-	S	-	-	-	Protein of unknown function (DUF3907)
MDDHOLLC_03349	7.84e-133	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MDDHOLLC_03350	2.85e-164	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MDDHOLLC_03352	5.71e-121	ypuF	-	-	S	ko:K09763	-	ko00000	Domain of unknown function (DUF309)
MDDHOLLC_03353	2.74e-84	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MDDHOLLC_03354	6.92e-106	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MDDHOLLC_03355	2.99e-290	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MDDHOLLC_03356	4.64e-143	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
MDDHOLLC_03357	1.93e-195	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MDDHOLLC_03358	8.62e-47	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MDDHOLLC_03359	2.01e-70	ypuD	-	-	-	-	-	-	-
MDDHOLLC_03360	6.56e-131	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MDDHOLLC_03361	5.56e-105	ccdC1	-	-	O	-	-	-	Protein of unknown function (DUF1453)
MDDHOLLC_03362	4.12e-104	ppiB	5.2.1.8	-	O	ko:K01802,ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MDDHOLLC_03363	3.65e-198	ypuA	-	-	S	-	-	-	Secreted protein
MDDHOLLC_03364	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MDDHOLLC_03365	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Stage V sporulation protein AF
MDDHOLLC_03366	7.55e-142	-	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
MDDHOLLC_03367	2.15e-75	spoVAEB	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
MDDHOLLC_03368	5.53e-242	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
MDDHOLLC_03369	9.92e-104	spoVAC	-	-	S	ko:K06405	-	ko00000	stage V sporulation protein AC
MDDHOLLC_03370	7.71e-90	spoVAB	-	-	S	ko:K06404	-	ko00000	Stage V sporulation protein AB
MDDHOLLC_03371	6.68e-143	spoVAA	-	-	S	ko:K06403	-	ko00000	Stage V sporulation protein AA
MDDHOLLC_03372	6.81e-174	sigF	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_03373	4.77e-100	spoIIAB	2.7.11.1	-	F	ko:K06379	-	ko00000,ko01000	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
MDDHOLLC_03374	4e-76	spoIIAA	-	-	T	ko:K06378	-	ko00000	Belongs to the anti-sigma-factor antagonist family
MDDHOLLC_03375	2.03e-272	dacF	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MDDHOLLC_03376	2.13e-190	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MDDHOLLC_03377	2.88e-293	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MDDHOLLC_03378	1.59e-213	xerD	-	-	L	ko:K04763	-	ko00000,ko03036	recombinase XerD
MDDHOLLC_03379	9.51e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF4227)
MDDHOLLC_03380	4.56e-104	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
MDDHOLLC_03381	5.01e-142	spoIIM	-	-	S	ko:K06384	-	ko00000	Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
MDDHOLLC_03383	8.54e-45	yqkK	-	-	-	-	-	-	-
MDDHOLLC_03384	1.96e-30	-	-	-	-	-	-	-	-
MDDHOLLC_03385	2.38e-309	mleA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
MDDHOLLC_03386	1.19e-311	mleN	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
MDDHOLLC_03387	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Aspartate ammonia-lyase
MDDHOLLC_03388	3.55e-237	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase
MDDHOLLC_03389	4e-76	ansR	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03390	5.91e-280	yqxK	-	-	L	-	-	-	DNA helicase
MDDHOLLC_03391	5.64e-46	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
MDDHOLLC_03392	2.27e-50	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
MDDHOLLC_03393	5.78e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF3936)
MDDHOLLC_03394	4.4e-216	yqkF	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
MDDHOLLC_03395	1.45e-11	yqkE	-	-	S	-	-	-	Protein of unknown function (DUF3886)
MDDHOLLC_03396	9.62e-225	yqkD	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
MDDHOLLC_03397	7.88e-54	yqkC	-	-	S	-	-	-	Protein of unknown function (DUF2552)
MDDHOLLC_03398	5.4e-80	yqkB	-	-	S	-	-	-	Belongs to the HesB IscA family
MDDHOLLC_03399	3.26e-220	yqkA	-	-	K	-	-	-	GrpB protein
MDDHOLLC_03400	3.46e-80	yqjZ	-	-	S	-	-	-	enzyme involved in biosynthesis of extracellular polysaccharides
MDDHOLLC_03401	1.15e-114	yqjY	-	-	K	ko:K06977	-	ko00000	acetyltransferase
MDDHOLLC_03402	2.59e-296	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDDHOLLC_03403	4.21e-72	-	-	-	S	-	-	-	YolD-like protein
MDDHOLLC_03405	6.05e-87	yueF	-	-	S	-	-	-	transporter activity
MDDHOLLC_03406	2.26e-110	yueF	-	-	S	-	-	-	transporter activity
MDDHOLLC_03408	2.2e-95	yqjT	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MDDHOLLC_03409	6.33e-227	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
MDDHOLLC_03410	1.04e-84	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
MDDHOLLC_03411	1.25e-207	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
MDDHOLLC_03412	2.39e-180	yqjQ	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MDDHOLLC_03413	3.63e-219	yqjP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MDDHOLLC_03414	8.24e-185	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MDDHOLLC_03415	1.38e-174	-	-	-	I	ko:K15313	-	ko00000,ko01008	Belongs to the enoyl-CoA hydratase isomerase family
MDDHOLLC_03416	2.48e-126	-	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
MDDHOLLC_03417	9.68e-146	-	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
MDDHOLLC_03418	3.29e-280	-	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MDDHOLLC_03419	0.0	-	1.6.5.5	-	C	ko:K00344	-	ko00000,ko01000	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MDDHOLLC_03420	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03421	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03422	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03423	4.88e-242	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03424	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03425	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03426	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03427	4.58e-40	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03428	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_03429	1.19e-149	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
MDDHOLLC_03430	4.54e-313	-	6.1.3.1, 6.2.1.3, 6.2.1.34	-	IQ	ko:K00666,ko:K01897,ko:K12508,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MDDHOLLC_03433	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MDDHOLLC_03434	4.32e-122	nusG1	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
MDDHOLLC_03435	6.96e-206	-	-	-	K	-	-	-	LysR substrate binding domain
MDDHOLLC_03436	2.62e-65	-	-	-	S	-	-	-	GlpM protein
MDDHOLLC_03437	1.27e-247	namA	1.6.99.1	-	C	ko:K00354	-	ko00000,ko01000	Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
MDDHOLLC_03438	1.24e-186	yqjL	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MDDHOLLC_03439	2.66e-218	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MDDHOLLC_03440	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MDDHOLLC_03441	0.0	gnd	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MDDHOLLC_03442	1.35e-301	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDDHOLLC_03443	1.3e-34	yqzJ	-	-	-	-	-	-	-
MDDHOLLC_03444	1.18e-190	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MDDHOLLC_03445	4.32e-258	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	COG2195 Di- and tripeptidases
MDDHOLLC_03446	1.64e-228	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MDDHOLLC_03447	2.51e-71	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MDDHOLLC_03448	1.89e-95	mce	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0346 Lactoylglutathione lyase and related lyases
MDDHOLLC_03449	3.7e-123	yqjB	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_03450	3.22e-219	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
MDDHOLLC_03451	6.07e-165	artM	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MDDHOLLC_03452	1.04e-141	artQ	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MDDHOLLC_03453	1.37e-173	artP	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MDDHOLLC_03454	1.68e-99	yqiW	-	-	S	-	-	-	Belongs to the UPF0403 family
MDDHOLLC_03455	1.42e-217	bmrU	-	-	I	-	-	-	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MDDHOLLC_03456	1.4e-281	bkdB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MDDHOLLC_03457	1.7e-235	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MDDHOLLC_03458	1.07e-219	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MDDHOLLC_03459	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MDDHOLLC_03460	1.57e-259	buk	2.7.2.7	-	C	ko:K00929	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	Belongs to the acetokinase family
MDDHOLLC_03461	1.58e-261	ldh	1.4.1.9	-	E	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MDDHOLLC_03462	1.31e-192	ptb	2.3.1.19	-	C	ko:K00634	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	phosphate butyryltransferase
MDDHOLLC_03463	0.0	bkdR	-	-	KT	-	-	-	Transcriptional regulator
MDDHOLLC_03464	6.25e-47	yqzF	-	-	S	-	-	-	Protein of unknown function (DUF2627)
MDDHOLLC_03465	2.7e-203	prpB	4.1.3.30, 5.4.2.9	-	G	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MDDHOLLC_03466	0.0	prpD	4.2.1.79	-	S	ko:K01720	ko00640,map00640	ko00000,ko00001,ko01000	2-methylcitrate dehydratase
MDDHOLLC_03467	2.71e-258	mmgD	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MDDHOLLC_03468	9.37e-256	mmgC	-	-	I	ko:K18244	-	ko00000,ko01000	acyl-CoA dehydrogenase
MDDHOLLC_03469	2.06e-198	mmgB	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	Dehydrogenase
MDDHOLLC_03470	6.26e-269	mmgA	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
MDDHOLLC_03471	4.29e-172	yqiK	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
MDDHOLLC_03472	1.97e-136	lytC_1	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Cell wall hydrolase autolysin
MDDHOLLC_03474	1.13e-130	-	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MDDHOLLC_03475	1.15e-145	-	-	-	K	-	-	-	Protein of unknown function (DUF1232)
MDDHOLLC_03477	5.59e-273	yqiG	-	-	C	-	-	-	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
MDDHOLLC_03480	2.9e-274	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MDDHOLLC_03481	6.11e-187	spo0A	-	-	KT	ko:K07699	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
MDDHOLLC_03482	8.85e-304	spoIVB	3.4.21.116	-	M	ko:K06399	-	ko00000,ko01000,ko01002	Stage IV sporulation protein B
MDDHOLLC_03483	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
MDDHOLLC_03484	4.38e-102	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
MDDHOLLC_03485	7.48e-129	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
MDDHOLLC_03486	1.47e-55	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
MDDHOLLC_03487	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MDDHOLLC_03488	1.57e-204	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
MDDHOLLC_03489	2.67e-52	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MDDHOLLC_03490	1.18e-309	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MDDHOLLC_03491	1.24e-199	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MDDHOLLC_03492	2.58e-85	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MDDHOLLC_03493	1.36e-87	yqhY	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_03494	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
MDDHOLLC_03495	1.63e-86	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MDDHOLLC_03496	2.74e-94	spoIIIAH	-	-	S	ko:K06397	-	ko00000	SpoIIIAH-like protein
MDDHOLLC_03497	3.34e-148	spoIIIAG	-	-	S	ko:K06396	-	ko00000	stage III sporulation protein AG
MDDHOLLC_03498	3.01e-130	spoIIIAF	-	-	S	ko:K06395	-	ko00000	Stage III sporulation protein AF (Spore_III_AF)
MDDHOLLC_03499	1.93e-183	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
MDDHOLLC_03500	5.09e-53	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
MDDHOLLC_03501	3.72e-55	spoIIIAD	-	-	S	ko:K06393	-	ko00000	Stage III sporulation protein AD
MDDHOLLC_03502	1.63e-39	spoIIIAC	-	-	S	ko:K06392	-	ko00000	stage III sporulation protein AC
MDDHOLLC_03503	1.57e-108	spoIIIAB	-	-	S	ko:K06391	-	ko00000	Stage III sporulation protein
MDDHOLLC_03504	4.43e-221	spoIIIAA	-	-	S	ko:K06390	-	ko00000	stage III sporulation protein AA
MDDHOLLC_03505	9.89e-50	yqhV	-	-	S	-	-	-	Protein of unknown function (DUF2619)
MDDHOLLC_03506	6.82e-128	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MDDHOLLC_03507	6.04e-249	yqhT	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
MDDHOLLC_03508	3.99e-118	yqhR	-	-	S	-	-	-	Conserved membrane protein YqhR
MDDHOLLC_03509	7.33e-221	yqhQ	-	-	S	-	-	-	Protein of unknown function (DUF1385)
MDDHOLLC_03510	4.5e-37	yqhP	-	-	-	-	-	-	-
MDDHOLLC_03511	1.09e-30	yqhP	-	-	-	-	-	-	-
MDDHOLLC_03512	1.11e-135	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
MDDHOLLC_03513	3.66e-61	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
MDDHOLLC_03514	6.59e-96	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
MDDHOLLC_03515	1.58e-204	lipM	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
MDDHOLLC_03516	3.18e-84	yqhL	-	-	P	-	-	-	COG0607 Rhodanese-related sulfurtransferase
MDDHOLLC_03517	0.0	gcvPB	1.4.4.2	-	E	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MDDHOLLC_03518	0.0	gcvPA	1.4.4.2	-	E	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MDDHOLLC_03519	3.32e-264	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine
MDDHOLLC_03520	2.93e-43	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
MDDHOLLC_03521	0.0	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
MDDHOLLC_03522	6.18e-195	yqhG	-	-	S	-	-	-	Bacterial protein YqhG of unknown function
MDDHOLLC_03523	2.31e-32	sinI	-	-	S	ko:K06372	-	ko00000	Anti-repressor SinI
MDDHOLLC_03524	2.75e-72	sinR	-	-	K	ko:K19449	-	ko00000,ko03000	transcriptional
MDDHOLLC_03525	1.49e-180	tasA_1	-	-	S	ko:K06336	-	ko00000,ko01002	Cell division protein FtsN
MDDHOLLC_03526	6.97e-78	sipW	3.4.21.89	-	U	ko:K13280	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase
MDDHOLLC_03527	2.7e-155	yqxM	-	-	-	ko:K19433	-	ko00000	-
MDDHOLLC_03528	1.97e-70	yqzG	-	-	S	-	-	-	Protein of unknown function (DUF3889)
MDDHOLLC_03529	2e-36	yqzE	-	-	S	-	-	-	YqzE-like protein
MDDHOLLC_03530	9.51e-81	-	-	-	S	ko:K02249	-	ko00000,ko00002,ko02044	ComG operon protein 7
MDDHOLLC_03531	2.21e-26	comGE	-	-	-	ko:K02247	-	ko00000,ko00002,ko02044	-
MDDHOLLC_03532	9.27e-93	-	-	-	NU	ko:K02246,ko:K08084	-	ko00000,ko00002,ko02044	Tfp pilus assembly protein FimT
MDDHOLLC_03533	4.46e-66	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
MDDHOLLC_03534	2.46e-92	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
MDDHOLLC_03535	4.6e-122	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
MDDHOLLC_03536	1.67e-211	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MDDHOLLC_03537	6.24e-35	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MDDHOLLC_03538	2.62e-238	yqxL	-	-	P	-	-	-	Mg2 transporter protein
MDDHOLLC_03539	4.37e-271	yqhB	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MDDHOLLC_03540	1.38e-188	yqhA	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MDDHOLLC_03542	1.15e-86	yqgZ	1.20.4.1	-	P	ko:K00537,ko:K16509	-	ko00000,ko01000	Belongs to the ArsC family
MDDHOLLC_03543	4.19e-50	yqgY	-	-	S	-	-	-	Protein of unknown function (DUF2626)
MDDHOLLC_03544	3.45e-157	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
MDDHOLLC_03545	4.36e-28	yqgW	-	-	S	-	-	-	Protein of unknown function (DUF2759)
MDDHOLLC_03546	3.5e-64	dglA	-	-	S	-	-	-	Thiamine-binding protein
MDDHOLLC_03547	8.58e-253	yqgU	-	-	-	-	-	-	-
MDDHOLLC_03548	3.14e-278	yqgT	3.4.19.11	-	E	ko:K01308	-	ko00000,ko01000,ko01002	Gamma-D-glutamyl-L-diamino acid endopeptidase
MDDHOLLC_03549	5.03e-229	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
MDDHOLLC_03550	1.51e-37	yqgQ	-	-	S	-	-	-	Protein conserved in bacteria
MDDHOLLC_03551	1.25e-299	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
MDDHOLLC_03552	3.79e-11	yqgO	-	-	-	-	-	-	-
MDDHOLLC_03553	2.47e-125	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MDDHOLLC_03554	6.25e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
MDDHOLLC_03555	3.42e-68	yqzD	-	-	-	-	-	-	-
MDDHOLLC_03556	4.15e-98	yqzC	-	-	S	-	-	-	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MDDHOLLC_03557	2.32e-188	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MDDHOLLC_03558	4.62e-183	pstBA	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MDDHOLLC_03559	3.26e-196	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
MDDHOLLC_03560	2.48e-203	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
MDDHOLLC_03561	9.5e-208	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
MDDHOLLC_03562	0.0	pbpA	-	-	M	ko:K21465,ko:K21466	ko00550,map00550	ko00000,ko00001,ko01011	penicillin-binding protein
MDDHOLLC_03563	9.63e-289	yqgE	-	-	EGP	ko:K08222	-	ko00000,ko02000	Major facilitator superfamily
MDDHOLLC_03564	4.22e-148	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
MDDHOLLC_03565	2.27e-98	yqgC	-	-	S	ko:K09793	-	ko00000	protein conserved in bacteria
MDDHOLLC_03566	1.53e-167	yqgB	-	-	S	-	-	-	Protein of unknown function (DUF1189)
MDDHOLLC_03567	3.05e-63	yqfZ	-	-	M	ko:K06417	-	ko00000	LysM domain
MDDHOLLC_03568	1.97e-256	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MDDHOLLC_03569	3.34e-80	yqfX	-	-	S	-	-	-	membrane
MDDHOLLC_03570	8.25e-142	yqfW	-	-	S	ko:K05967	-	ko00000	Belongs to the 5'(3')-deoxyribonucleotidase family
MDDHOLLC_03571	2.25e-100	zur	-	-	P	ko:K02076	-	ko00000,ko03000	Belongs to the Fur family
MDDHOLLC_03572	6.35e-198	yqfU	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MDDHOLLC_03573	8.63e-49	yqfT	-	-	S	-	-	-	Protein of unknown function (DUF2624)
MDDHOLLC_03574	2.86e-212	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MDDHOLLC_03575	1.05e-308	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MDDHOLLC_03576	4.54e-86	yqfQ	-	-	S	-	-	-	YqfQ-like protein
MDDHOLLC_03577	5.01e-226	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MDDHOLLC_03578	1.47e-266	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MDDHOLLC_03579	6e-162	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
MDDHOLLC_03580	9.68e-83	cccA	-	-	C	ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
MDDHOLLC_03581	3.97e-255	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MDDHOLLC_03582	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MDDHOLLC_03583	1.36e-112	yqxD	-	-	S	ko:K09768	-	ko00000	Belongs to the UPF0178 family
MDDHOLLC_03584	5.46e-192	yqfL	2.7.11.33, 2.7.4.28	-	S	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
MDDHOLLC_03585	5.89e-145	ccpN	-	-	K	-	-	-	CBS domain
MDDHOLLC_03586	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
MDDHOLLC_03587	5.19e-223	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
MDDHOLLC_03588	5.05e-185	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
MDDHOLLC_03589	8.2e-214	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MDDHOLLC_03590	1.92e-92	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MDDHOLLC_03591	5.28e-83	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
MDDHOLLC_03592	1.44e-104	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MDDHOLLC_03593	0.0	yqfF	-	-	S	ko:K07037	-	ko00000	membrane-associated HD superfamily hydrolase
MDDHOLLC_03594	7.08e-224	phoH	-	-	T	ko:K06217	-	ko00000	Phosphate starvation-inducible protein PhoH
MDDHOLLC_03595	3.72e-282	yqfD	-	-	S	ko:K06438	-	ko00000	Stage IV sporulation
MDDHOLLC_03596	3.57e-61	yqfC	-	-	S	-	-	-	sporulation protein YqfC
MDDHOLLC_03597	1.58e-79	yqfB	-	-	-	-	-	-	-
MDDHOLLC_03598	1.3e-174	yqfA	-	-	S	-	-	-	UPF0365 protein
MDDHOLLC_03599	2.21e-294	yqeZ	-	-	O	ko:K07403	-	ko00000	COG1030 Membrane-bound serine protease (ClpP class)
MDDHOLLC_03600	6.44e-90	yqeY	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
MDDHOLLC_03601	1.03e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
MDDHOLLC_03602	5.35e-199	yqeW	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
MDDHOLLC_03603	0.0	yqeV	2.8.4.5	-	J	ko:K18707	-	ko00000,ko01000,ko03016	ribosomal protein S12 methylthiotransferase
MDDHOLLC_03604	1.44e-180	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MDDHOLLC_03605	6.31e-223	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Methylates ribosomal protein L11
MDDHOLLC_03606	4.93e-266	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MDDHOLLC_03607	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
MDDHOLLC_03608	5.18e-110	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MDDHOLLC_03609	2.73e-240	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MDDHOLLC_03610	1.96e-274	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
MDDHOLLC_03611	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MDDHOLLC_03612	3.5e-70	yqxA	-	-	S	-	-	-	Protein of unknown function (DUF3679)
MDDHOLLC_03613	1.51e-278	spoIIP	-	-	M	ko:K06385	-	ko00000	stage II sporulation protein P
MDDHOLLC_03614	1.02e-259	gpr	3.4.24.78	-	C	ko:K06012	-	ko00000,ko01000,ko01002	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MDDHOLLC_03615	1.91e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
MDDHOLLC_03616	7.42e-232	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
MDDHOLLC_03617	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
MDDHOLLC_03618	3.79e-136	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
MDDHOLLC_03619	1.63e-133	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
MDDHOLLC_03620	8.04e-191	comER	-	-	E	ko:K02239	-	ko00000,ko00002,ko02044	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MDDHOLLC_03621	4.86e-178	yqeM	-	-	Q	-	-	-	Methyltransferase
MDDHOLLC_03622	9.39e-80	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MDDHOLLC_03623	3.7e-132	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
MDDHOLLC_03624	6.82e-139	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MDDHOLLC_03625	1.81e-60	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein containing KH domain, possibly ribosomal protein
MDDHOLLC_03626	1.7e-200	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MDDHOLLC_03627	1.31e-270	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
MDDHOLLC_03628	3.19e-122	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
MDDHOLLC_03630	3.32e-135	yqeF	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
MDDHOLLC_03631	6.45e-30	yqeF	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
MDDHOLLC_03632	2.6e-177	pdaC	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
MDDHOLLC_03633	6.87e-137	yqeD	-	-	S	-	-	-	SNARE associated Golgi protein
MDDHOLLC_03634	1.77e-267	-	-	-	EGP	-	-	-	Transmembrane secretion effector
MDDHOLLC_03635	6.38e-79	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_03636	2.85e-46	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDDHOLLC_03637	3.83e-200	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
MDDHOLLC_03638	2.23e-119	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
MDDHOLLC_03639	1.81e-258	-	-	-	S	-	-	-	Bacterial EndoU nuclease
MDDHOLLC_03640	3.93e-13	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
MDDHOLLC_03642	1.6e-188	ydeE	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
MDDHOLLC_03643	1.02e-123	yqaC	-	-	F	-	-	-	adenylate kinase activity
MDDHOLLC_03644	4.65e-42	-	-	-	K	-	-	-	acetyltransferase
MDDHOLLC_03645	6.22e-279	tetL	-	-	EGP	ko:K08168	-	ko00000,ko00002,ko01504,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_03647	1.94e-39	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	nucleic acid phosphodiester bond hydrolysis
MDDHOLLC_03649	5.83e-101	-	-	-	M	-	-	-	Psort location Cytoplasmic, score
MDDHOLLC_03651	2.61e-51	-	-	-	K	-	-	-	acetyltransferase
MDDHOLLC_03652	6.34e-114	-	-	-	S	-	-	-	DinB family
MDDHOLLC_03654	9.38e-187	supH	-	-	S	-	-	-	hydrolase
MDDHOLLC_03655	1.13e-184	supH	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
MDDHOLLC_03656	1.96e-166	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
MDDHOLLC_03657	1.29e-233	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MDDHOLLC_03658	0.0	manP	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MDDHOLLC_03659	0.0	manR	-	-	GKT	ko:K02538,ko:K03491	-	ko00000,ko03000	transcriptional antiterminator
MDDHOLLC_03660	1.62e-52	romA	-	-	S	-	-	-	Beta-lactamase superfamily domain
MDDHOLLC_03661	5.25e-115	romA	-	-	S	-	-	-	Beta-lactamase superfamily domain
MDDHOLLC_03662	8.95e-105	ebsC	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MDDHOLLC_03663	4.38e-210	yybE	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03664	2.18e-269	yybF1	-	-	EGP	ko:K08224	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_03665	0.0	yrhJ	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
MDDHOLLC_03666	4.77e-130	-	-	-	K	ko:K22106	-	ko00000,ko03000	Tetracycline repressor, C-terminal all-alpha domain
MDDHOLLC_03667	1.75e-118	yrhH	-	-	Q	-	-	-	methyltransferase
MDDHOLLC_03668	2.37e-07	-	-	-	S	-	-	-	Probable sporulation protein (Bac_small_yrzI)
MDDHOLLC_03669	3.96e-183	yrhG	-	-	P	ko:K21993	-	ko00000,ko02000	Formate nitrite
MDDHOLLC_03670	1.48e-78	yrhF	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2294)
MDDHOLLC_03671	0.0	yrhE	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase, alpha subunit
MDDHOLLC_03672	4.76e-106	yrhD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MDDHOLLC_03673	5.51e-46	yrhC	-	-	S	-	-	-	YrhC-like protein
MDDHOLLC_03674	7.59e-268	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MDDHOLLC_03675	1.61e-218	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Cysteine synthase
MDDHOLLC_03676	5.64e-161	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MDDHOLLC_03677	1.35e-150	yrrT	-	-	Q	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Could be a S-adenosyl-L-methionine-dependent methyltransferase
MDDHOLLC_03678	1.78e-38	yrzA	-	-	S	-	-	-	Protein of unknown function (DUF2536)
MDDHOLLC_03679	3.56e-124	yrrS	-	-	S	-	-	-	Protein of unknown function (DUF1510)
MDDHOLLC_03680	0.0	pbpI	-	-	M	ko:K21468	-	ko00000,ko01011	Penicillin-binding Protein
MDDHOLLC_03681	1.62e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MDDHOLLC_03682	2.61e-147	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
MDDHOLLC_03683	1.09e-311	yrrO	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	COG0826 Collagenase and related proteases
MDDHOLLC_03684	6.3e-222	yrrN	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
MDDHOLLC_03685	2.22e-151	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-methyltransferase
MDDHOLLC_03686	7.46e-196	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MDDHOLLC_03687	3.48e-44	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MDDHOLLC_03688	7.2e-61	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
MDDHOLLC_03689	2.72e-93	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MDDHOLLC_03690	1.29e-54	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
MDDHOLLC_03691	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MDDHOLLC_03692	1.81e-25	yrrI	-	-	S	-	-	-	AI-2E family transporter
MDDHOLLC_03693	1.08e-189	yrrI	-	-	S	-	-	-	AI-2E family transporter
MDDHOLLC_03694	3.66e-167	glnQ	-	-	E	ko:K09972,ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MDDHOLLC_03695	1.82e-188	glnH	-	-	ET	ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MDDHOLLC_03696	3.24e-139	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MDDHOLLC_03697	8.88e-138	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MDDHOLLC_03698	6.52e-13	-	-	-	S	-	-	-	Protein of unknown function (DUF3918)
MDDHOLLC_03699	8.4e-42	yrzR	-	-	-	-	-	-	-
MDDHOLLC_03700	1.69e-105	yrrD	-	-	S	-	-	-	protein conserved in bacteria
MDDHOLLC_03701	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MDDHOLLC_03702	2.2e-23	yrrB	-	-	S	-	-	-	COG0457 FOG TPR repeat
MDDHOLLC_03703	5.88e-281	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MDDHOLLC_03704	2.98e-269	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MDDHOLLC_03705	9.19e-84	cymR	-	-	K	ko:K17472	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03706	3.39e-282	rarA	-	-	L	ko:K07478	-	ko00000	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
MDDHOLLC_03707	1.96e-177	yrvM	-	-	H	ko:K22132	-	ko00000,ko03016	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
MDDHOLLC_03708	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MDDHOLLC_03709	1.27e-286	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
MDDHOLLC_03713	0.0	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
MDDHOLLC_03714	4.95e-98	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MDDHOLLC_03715	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MDDHOLLC_03716	5.1e-118	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MDDHOLLC_03717	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
MDDHOLLC_03718	7.78e-63	yrvD	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
MDDHOLLC_03719	8.88e-112	trkA1	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
MDDHOLLC_03720	0.0	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MDDHOLLC_03721	4.04e-67	yrzD	-	-	S	-	-	-	Post-transcriptional regulator
MDDHOLLC_03722	0.0	spoVB	-	-	S	ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_03723	2.03e-143	yrbG	-	-	S	-	-	-	membrane
MDDHOLLC_03724	9.08e-81	yrzE	-	-	S	-	-	-	Protein of unknown function (DUF3792)
MDDHOLLC_03725	1.03e-50	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit YajC
MDDHOLLC_03726	8.2e-293	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MDDHOLLC_03727	6.75e-245	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MDDHOLLC_03728	9.76e-29	yrzS	-	-	S	-	-	-	Protein of unknown function (DUF2905)
MDDHOLLC_03729	1.45e-235	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MDDHOLLC_03730	8.13e-137	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MDDHOLLC_03731	1.03e-121	bofC	-	-	S	ko:K06318	-	ko00000	BofC C-terminal domain
MDDHOLLC_03733	1.91e-62	-	-	-	S	ko:K06345	-	ko00000	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MDDHOLLC_03734	6.04e-247	safA	-	-	M	ko:K06370	-	ko00000	spore coat assembly protein SafA
MDDHOLLC_03735	2.02e-270	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MDDHOLLC_03736	1.01e-193	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NadC ModD family
MDDHOLLC_03737	0.0	nadB	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
MDDHOLLC_03738	3.17e-282	nifS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MDDHOLLC_03739	4.82e-121	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
MDDHOLLC_03740	8.16e-206	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
MDDHOLLC_03741	5.94e-95	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
MDDHOLLC_03742	2.37e-309	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MDDHOLLC_03743	3.5e-138	spo0B	-	-	T	ko:K06375	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01000	Sporulation initiation phospho-transferase B, C-terminal
MDDHOLLC_03744	7.74e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
MDDHOLLC_03745	1.42e-74	ysxB	-	-	J	ko:K07584	-	ko00000	ribosomal protein
MDDHOLLC_03746	1.28e-65	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
MDDHOLLC_03747	1.2e-204	spoIVFB	-	-	S	ko:K06402	-	ko00000,ko01000,ko01002	Stage IV sporulation protein
MDDHOLLC_03748	1.39e-188	spoIVFA	-	-	M	ko:K06401	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
MDDHOLLC_03749	1.61e-183	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
MDDHOLLC_03750	6.85e-155	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
MDDHOLLC_03751	1.76e-110	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	shape-determining protein
MDDHOLLC_03752	2.51e-201	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
MDDHOLLC_03753	1.06e-234	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein MreB
MDDHOLLC_03754	8.35e-163	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
MDDHOLLC_03755	5.35e-127	maf	-	-	D	ko:K06287	-	ko00000	septum formation protein Maf
MDDHOLLC_03756	2.55e-208	spoIIB	-	-	S	ko:K06380	-	ko00000	Sporulation related domain
MDDHOLLC_03757	4.26e-170	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
MDDHOLLC_03758	2.97e-304	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
MDDHOLLC_03759	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MDDHOLLC_03760	1.53e-35	-	-	-	-	-	-	-	-
MDDHOLLC_03761	3.66e-249	ysxE	-	-	S	-	-	-	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MDDHOLLC_03762	3.75e-301	spoVID	-	-	M	ko:K06417	-	ko00000	stage VI sporulation protein D
MDDHOLLC_03763	2.14e-240	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MDDHOLLC_03764	5.53e-48	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MDDHOLLC_03765	1.02e-235	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the ALAD family
MDDHOLLC_03766	3.82e-180	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
MDDHOLLC_03767	1.05e-222	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
MDDHOLLC_03768	2.67e-186	hemX	-	-	O	ko:K02497	-	ko00000	cytochrome C
MDDHOLLC_03769	1.24e-314	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MDDHOLLC_03770	1.32e-112	ysxD	-	-	-	-	-	-	-
MDDHOLLC_03771	1.19e-102	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
MDDHOLLC_03772	3.35e-05	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
MDDHOLLC_03773	0.0	lon	3.4.21.53	-	O	ko:K01338	ko04112,map04112	ko00000,ko00001,ko01000,ko01002	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MDDHOLLC_03774	0.0	lonB	3.4.21.53	-	LO	ko:K04076	-	ko00000,ko01000,ko01002	Belongs to the peptidase S16 family
MDDHOLLC_03775	3.83e-295	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MDDHOLLC_03776	2.18e-287	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MDDHOLLC_03777	2.25e-239	ysoA	-	-	H	-	-	-	Tetratricopeptide repeat
MDDHOLLC_03778	3.77e-150	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MDDHOLLC_03779	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MDDHOLLC_03780	7.12e-254	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MDDHOLLC_03781	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MDDHOLLC_03782	2.75e-244	ilvC	1.1.1.86	-	EH	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MDDHOLLC_03783	2.06e-109	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
MDDHOLLC_03784	0.0	ilvB	2.2.1.6	-	E	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
MDDHOLLC_03787	2.53e-156	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
MDDHOLLC_03788	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	Type I restriction-modification system
MDDHOLLC_03789	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
MDDHOLLC_03793	6.72e-118	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
MDDHOLLC_03794	1.59e-131	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MDDHOLLC_03795	4.12e-170	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MDDHOLLC_03796	6.08e-253	gerM	-	-	S	ko:K06298	-	ko00000	COG5401 Spore germination protein
MDDHOLLC_03797	1.15e-196	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
MDDHOLLC_03798	3.77e-97	ysmB	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MDDHOLLC_03799	6.32e-42	gerE	-	-	K	ko:K01994	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03800	2.19e-100	ysmA	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
MDDHOLLC_03801	4.34e-189	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
MDDHOLLC_03802	0.0	sdhA	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
MDDHOLLC_03803	2.73e-140	sdhC	-	-	C	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	succinate dehydrogenase
MDDHOLLC_03804	1.66e-101	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
MDDHOLLC_03805	1.01e-273	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MDDHOLLC_03806	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MDDHOLLC_03807	1.6e-69	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
MDDHOLLC_03808	0.0	xsa	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	Alpha-L-arabinofuranosidase C-terminus
MDDHOLLC_03809	1.43e-226	etfA	-	-	C	ko:K03522	-	ko00000,ko04147	Electron transfer flavoprotein
MDDHOLLC_03810	1.01e-176	etfB	-	-	C	ko:K03521	-	ko00000	Electron transfer flavoprotein
MDDHOLLC_03811	1.23e-178	fadB	4.2.1.17	-	I	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
MDDHOLLC_03812	1.78e-133	fadR	-	-	K	ko:K13770	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03813	0.0	lcfA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MDDHOLLC_03814	2.06e-56	ywbB	-	-	S	-	-	-	Protein of unknown function (DUF2711)
MDDHOLLC_03815	3.09e-88	yshE	-	-	S	ko:K08989	-	ko00000	membrane
MDDHOLLC_03816	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MDDHOLLC_03817	0.0	polX	-	-	L	ko:K02347	-	ko00000,ko03400	COG1796 DNA polymerase IV (family X)
MDDHOLLC_03818	3.5e-108	yshB	-	-	S	-	-	-	membrane protein, required for colicin V production
MDDHOLLC_03819	4.23e-54	zapA	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MDDHOLLC_03820	4.38e-215	rnhC	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MDDHOLLC_03821	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MDDHOLLC_03822	2.19e-249	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MDDHOLLC_03823	4.63e-173	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MDDHOLLC_03824	1.07e-43	sspI	-	-	S	ko:K06426	-	ko00000	Belongs to the SspI family
MDDHOLLC_03825	2.81e-258	cdaR_1	-	-	KT	ko:K02647	-	ko00000,ko03000	regulator
MDDHOLLC_03826	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD binding domain
MDDHOLLC_03827	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
MDDHOLLC_03828	0.0	cstA	-	-	T	ko:K06200	-	ko00000	Carbon starvation protein
MDDHOLLC_03829	0.0	abfA	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	alpha-L-arabinofuranosidase activity
MDDHOLLC_03830	3.03e-88	araQ	-	-	G	ko:K17236	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport system permease
MDDHOLLC_03831	3.19e-91	araQ	-	-	G	ko:K17236	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport system permease
MDDHOLLC_03832	4.2e-213	araP	-	-	P	ko:K10189,ko:K10241,ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
MDDHOLLC_03833	0.0	araN	-	-	G	ko:K17234	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	carbohydrate transport
MDDHOLLC_03834	2.34e-285	araM	1.1.1.261	-	I	ko:K00096	ko00564,map00564	ko00000,ko00001,ko01000	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
MDDHOLLC_03835	4.95e-142	araL	-	-	G	ko:K02101	-	ko00000	Haloacid dehalogenase-like hydrolase
MDDHOLLC_03836	3.43e-170	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
MDDHOLLC_03837	0.0	araB	2.7.1.16	-	C	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Belongs to the ribulokinase family
MDDHOLLC_03838	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
MDDHOLLC_03839	8.14e-240	abnA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
MDDHOLLC_03840	1.85e-263	ysdC	-	-	G	-	-	-	COG1363 Cellulase M and related proteins
MDDHOLLC_03841	3.13e-86	ysdB	-	-	S	-	-	-	Sigma-w pathway protein YsdB
MDDHOLLC_03842	5.44e-56	ysdA	-	-	S	-	-	-	Membrane
MDDHOLLC_03843	3.26e-76	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MDDHOLLC_03844	1.95e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
MDDHOLLC_03845	1.79e-112	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MDDHOLLC_03846	2.09e-145	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MDDHOLLC_03847	7.85e-67	-	-	-	S	ko:K05338	ko02020,map02020	ko00000,ko00001,ko02000	effector of murein hydrolase LrgA
MDDHOLLC_03848	4.98e-166	lytT	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
MDDHOLLC_03849	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MDDHOLLC_03850	6.92e-192	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
MDDHOLLC_03851	1.5e-258	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MDDHOLLC_03852	1.46e-177	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MDDHOLLC_03853	1.63e-196	ytxC	-	-	S	-	-	-	YtxC-like family
MDDHOLLC_03854	3.51e-137	ytxB	-	-	S	-	-	-	SNARE associated Golgi protein
MDDHOLLC_03855	2.87e-219	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
MDDHOLLC_03856	8.41e-241	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
MDDHOLLC_03857	2.42e-79	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
MDDHOLLC_03858	5.95e-106	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MDDHOLLC_03859	4.31e-56	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MDDHOLLC_03860	1.14e-13	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MDDHOLLC_03861	8.56e-247	gapB	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MDDHOLLC_03862	1.69e-89	ytcD	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03863	2.79e-259	ytbD	-	-	EGP	ko:K19577	-	ko00000,ko02000	-transporter
MDDHOLLC_03864	3.74e-204	ytbE	-	-	S	-	-	-	reductase
MDDHOLLC_03865	3.43e-127	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MDDHOLLC_03866	5.73e-138	ytaF	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MDDHOLLC_03867	2.32e-201	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MDDHOLLC_03868	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MDDHOLLC_03869	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase
MDDHOLLC_03870	2.9e-167	phoP	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_03871	3.62e-218	mdh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible oxidation of malate to oxaloacetate
MDDHOLLC_03872	5.36e-308	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	isocitrate
MDDHOLLC_03873	1.42e-268	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MDDHOLLC_03874	1.24e-79	yjdF3	-	-	S	-	-	-	Protein of unknown function (DUF2992)
MDDHOLLC_03875	5.65e-96	ytwI	-	-	S	-	-	-	membrane
MDDHOLLC_03876	4.05e-247	ytvI	-	-	S	-	-	-	sporulation integral membrane protein YtvI
MDDHOLLC_03877	3.42e-84	fxsA	-	-	S	ko:K07113	-	ko00000	COG3030 Protein affecting phage T7 exclusion by the F plasmid
MDDHOLLC_03878	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
MDDHOLLC_03879	1.49e-30	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
MDDHOLLC_03880	1.14e-229	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MDDHOLLC_03881	1.34e-231	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MDDHOLLC_03882	2.08e-206	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MDDHOLLC_03883	2.45e-286	ytsJ	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
MDDHOLLC_03884	1.05e-29	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
MDDHOLLC_03885	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
MDDHOLLC_03886	4.94e-75	ytrH	-	-	S	-	-	-	Sporulation protein YtrH
MDDHOLLC_03887	2.31e-58	ytrI	-	-	-	-	-	-	-
MDDHOLLC_03888	7.09e-37	ytrI	-	-	-	-	-	-	-
MDDHOLLC_03889	1e-31	-	-	-	-	-	-	-	-
MDDHOLLC_03890	2.14e-231	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	COG0618 Exopolyphosphatase-related proteins
MDDHOLLC_03891	3.57e-62	ytpI	-	-	S	-	-	-	YtpI-like protein
MDDHOLLC_03892	1.31e-302	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
MDDHOLLC_03893	4.86e-165	ytkL	-	-	S	-	-	-	Belongs to the UPF0173 family
MDDHOLLC_03894	1.98e-182	ytkK	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MDDHOLLC_03896	1.58e-39	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
MDDHOLLC_03897	1.13e-273	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
MDDHOLLC_03898	3.03e-297	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
MDDHOLLC_03899	3.31e-114	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
MDDHOLLC_03900	1.57e-279	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MDDHOLLC_03901	1.69e-231	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
MDDHOLLC_03902	1.12e-115	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MDDHOLLC_03903	4.77e-100	ytfJ	-	-	S	-	-	-	Sporulation protein YtfJ
MDDHOLLC_03904	1.26e-147	ytfI	-	-	S	-	-	-	Protein of unknown function (DUF2953)
MDDHOLLC_03905	2.77e-114	yteJ	-	-	S	-	-	-	RDD family
MDDHOLLC_03906	6.39e-235	sppA	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	signal peptide peptidase SppA
MDDHOLLC_03907	3.16e-194	nadK2	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MDDHOLLC_03908	0.0	ytcJ	-	-	S	-	-	-	amidohydrolase
MDDHOLLC_03909	0.0	ytcI	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MDDHOLLC_03910	2.05e-42	sspB	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
MDDHOLLC_03911	2.34e-284	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MDDHOLLC_03912	1.59e-265	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MDDHOLLC_03913	1.32e-306	braB	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
MDDHOLLC_03914	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MDDHOLLC_03915	8.43e-196	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	COG1387 Histidinol phosphatase and related hydrolases of the PHP family
MDDHOLLC_03916	2.41e-141	yttP	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03917	7.1e-111	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
MDDHOLLC_03918	0.0	ytrP	-	-	T	-	-	-	COG2199 FOG GGDEF domain
MDDHOLLC_03919	8.56e-99	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MDDHOLLC_03920	0.0	ywdH	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MDDHOLLC_03921	8.29e-129	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
MDDHOLLC_03922	6.9e-279	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MDDHOLLC_03924	1.93e-117	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
MDDHOLLC_03926	1.89e-173	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
MDDHOLLC_03928	1.74e-105	-	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDDHOLLC_03929	3.65e-71	-	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDDHOLLC_03930	1.29e-189	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_03931	1.16e-159	ygaZ	-	-	E	-	-	-	AzlC protein
MDDHOLLC_03932	2.07e-62	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
MDDHOLLC_03933	3.46e-303	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MDDHOLLC_03934	0.0	acsA	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MDDHOLLC_03935	2.84e-155	acuA	-	-	K	ko:K04766	-	ko00000,ko01000	Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
MDDHOLLC_03936	1.19e-149	acuB	-	-	S	ko:K04767	-	ko00000	Domain in cystathionine beta-synthase and other proteins.
MDDHOLLC_03937	1.73e-252	acuC	-	-	BQ	ko:K04768	-	ko00000	histone deacetylase
MDDHOLLC_03938	5.2e-186	motP	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
MDDHOLLC_03939	2.41e-234	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
MDDHOLLC_03940	1.54e-249	aroA	2.5.1.54, 5.4.99.5	-	E	ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
MDDHOLLC_03941	5.67e-56	ytxJ	-	-	O	-	-	-	Protein of unknown function (DUF2847)
MDDHOLLC_03942	1.83e-30	ytxH	-	-	S	-	-	-	COG4980 Gas vesicle protein
MDDHOLLC_03943	5.38e-26	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MDDHOLLC_03944	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
MDDHOLLC_03945	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
MDDHOLLC_03946	2.08e-139	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MDDHOLLC_03947	3.98e-189	ytpQ	-	-	S	-	-	-	Belongs to the UPF0354 family
MDDHOLLC_03948	5.47e-76	ytpP	-	-	CO	-	-	-	Thioredoxin
MDDHOLLC_03949	3.91e-100	ytoQ	-	-	S	-	-	-	Nucleoside 2-deoxyribosyltransferase YtoQ
MDDHOLLC_03950	4.33e-260	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
MDDHOLLC_03951	9.96e-69	ytzB	-	-	S	-	-	-	small secreted protein
MDDHOLLC_03952	0.0	malS	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
MDDHOLLC_03953	1.4e-40	malS	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
MDDHOLLC_03954	5.12e-207	ytnP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MDDHOLLC_03955	6.43e-160	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MDDHOLLC_03956	3.88e-60	ytzH	-	-	S	-	-	-	YtzH-like protein
MDDHOLLC_03957	2.58e-99	ytmP	-	-	M	-	-	-	Phosphotransferase
MDDHOLLC_03958	3.8e-71	ytmP	-	-	M	-	-	-	Phosphotransferase
MDDHOLLC_03959	4.62e-224	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
MDDHOLLC_03960	4.18e-211	ytlQ	-	-	-	-	-	-	-
MDDHOLLC_03961	6.34e-132	ytlP	3.1.4.58	-	J	ko:K01975	-	ko00000,ko01000,ko03016	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MDDHOLLC_03962	6.81e-222	ytkP	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
MDDHOLLC_03963	0.0	ytjP	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Dipeptidase
MDDHOLLC_03964	1.42e-288	pbuO	-	-	S	ko:K06901	-	ko00000,ko02000	permease
MDDHOLLC_03965	1.18e-274	ythQ	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	Bacterial ABC transporter protein EcsB
MDDHOLLC_03966	5.44e-165	ythP	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
MDDHOLLC_03967	4.46e-46	ytzE	-	-	K	-	-	-	COG1349 Transcriptional regulators of sugar metabolism
MDDHOLLC_03968	2.49e-168	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
MDDHOLLC_03969	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MDDHOLLC_03970	5.3e-299	ytfP	-	-	S	ko:K07007	-	ko00000	HI0933-like protein
MDDHOLLC_03971	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
MDDHOLLC_03972	2.14e-36	yteV	-	-	S	-	-	-	Sporulation protein Cse60
MDDHOLLC_03973	4.52e-238	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
MDDHOLLC_03974	4.42e-308	msmE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MDDHOLLC_03975	5.58e-218	-	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MDDHOLLC_03976	1.67e-183	amyC	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MDDHOLLC_03977	9.62e-317	melA	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
MDDHOLLC_03978	1.42e-103	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
MDDHOLLC_03979	2.04e-22	ytwF	-	-	P	-	-	-	Sulfurtransferase
MDDHOLLC_03980	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
MDDHOLLC_03981	7.19e-69	ytvB	-	-	S	-	-	-	Protein of unknown function (DUF4257)
MDDHOLLC_03982	1.32e-174	pfyP	-	-	T	-	-	-	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MDDHOLLC_03983	2.02e-223	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
MDDHOLLC_03984	9.95e-33	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
MDDHOLLC_03985	1.47e-157	ywaF	-	-	S	-	-	-	Integral membrane protein
MDDHOLLC_03986	0.0	bceB	-	-	V	ko:K02004,ko:K11632,ko:K19080	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter (permease)
MDDHOLLC_03987	2.2e-172	bceA	-	-	V	ko:K02003,ko:K11631,ko:K19079	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_03988	6.12e-222	bceS	2.7.13.3	-	T	ko:K11629,ko:K19077	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	His Kinase A (phosphoacceptor) domain
MDDHOLLC_03989	4.49e-167	graR	-	-	T	ko:K11630,ko:K19078	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01504,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MDDHOLLC_03990	3.9e-287	ytrF	-	-	V	ko:K02004,ko:K16918	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
MDDHOLLC_03991	3.01e-161	ytrE	-	-	V	ko:K16920	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_03992	4.74e-203	-	-	-	-	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	-
MDDHOLLC_03993	5.65e-230	-	-	-	P	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MDDHOLLC_03994	2.23e-215	ytrC	-	-	S	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MDDHOLLC_03995	5.11e-208	ytrB	-	-	P	ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MDDHOLLC_03996	2.68e-87	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	GntR family transcriptional regulator
MDDHOLLC_03998	7.09e-53	ytzC	-	-	S	-	-	-	Protein of unknown function (DUF2524)
MDDHOLLC_03999	0.0	-	-	-	IQ	-	-	-	AMP-binding enzyme
MDDHOLLC_04000	2.32e-259	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MDDHOLLC_04001	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MDDHOLLC_04002	0.0	-	-	-	Q	ko:K04784,ko:K12240	ko01053,map01053	ko00000,ko00001,ko01004,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_04003	2.69e-31	-	-	-	Q	ko:K04784,ko:K12240	ko01053,map01053	ko00000,ko00001,ko01004,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_04004	0.0	-	-	-	Q	ko:K04784,ko:K12240	ko01053,map01053	ko00000,ko00001,ko01004,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_04005	0.0	-	-	-	Q	ko:K04784,ko:K12240	ko01053,map01053	ko00000,ko00001,ko01004,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MDDHOLLC_04006	1.03e-236	-	-	-	C	-	-	-	Nitroreductase
MDDHOLLC_04007	2.58e-163	aveG	-	-	Q	-	-	-	Thioesterase domain
MDDHOLLC_04008	2.3e-278	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_04009	4.66e-70	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MDDHOLLC_04010	6.73e-244	ytqA	-	-	S	ko:K07139	-	ko00000	Fe-S oxidoreductase
MDDHOLLC_04011	1.48e-135	ytqB	-	-	J	-	-	-	Putative rRNA methylase
MDDHOLLC_04013	3.42e-148	-	3.1.4.46, 5.4.2.11	-	C	ko:K01126,ko:K01834	ko00010,ko00260,ko00564,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00564,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	glycerophosphoryl diester phosphodiesterase
MDDHOLLC_04014	2.35e-270	ytpB	4.2.3.130	-	S	ko:K16188	-	ko00000,ko01000	Tetraprenyl-beta-curcumene synthase
MDDHOLLC_04015	4.02e-193	ytpA	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
MDDHOLLC_04016	8.19e-84	ytoA	-	-	S	-	-	-	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MDDHOLLC_04017	2.72e-113	ytnA	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_04018	1.05e-193	ytnA	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MDDHOLLC_04019	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
MDDHOLLC_04020	3.94e-47	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
MDDHOLLC_04021	7.88e-287	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MDDHOLLC_04022	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MDDHOLLC_04023	2.85e-52	ytmB	-	-	S	-	-	-	Protein of unknown function (DUF2584)
MDDHOLLC_04024	7.79e-190	ytmA	-	-	E	-	-	-	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
MDDHOLLC_04025	2.93e-235	ytlA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
MDDHOLLC_04026	6.12e-184	ytlC	3.6.3.36	-	P	ko:K02049,ko:K10831,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MDDHOLLC_04027	7.52e-174	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MDDHOLLC_04028	1.01e-114	ytkD	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MDDHOLLC_04029	3.51e-79	ytkC	-	-	S	-	-	-	Bacteriophage holin family
MDDHOLLC_04030	3e-98	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
MDDHOLLC_04032	4.95e-98	ytkA	-	-	S	-	-	-	YtkA-like
MDDHOLLC_04033	7.16e-114	luxS	4.4.1.21	-	T	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MDDHOLLC_04034	1.99e-52	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
MDDHOLLC_04035	9.31e-137	ytiB	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
MDDHOLLC_04036	7.13e-56	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
MDDHOLLC_04037	4.48e-313	ythA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
MDDHOLLC_04038	1.29e-235	ythB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
MDDHOLLC_04039	3.2e-33	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1540)
MDDHOLLC_04040	4.09e-272	menC	4.2.1.113	-	H	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MDDHOLLC_04041	0.0	menE	6.2.1.26	-	H	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
MDDHOLLC_04042	2.52e-198	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MDDHOLLC_04043	5.94e-198	menH	4.2.99.20	-	S	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
MDDHOLLC_04044	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MDDHOLLC_04045	1.08e-54	menF	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
MDDHOLLC_04046	3.78e-251	menF	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
MDDHOLLC_04047	1.36e-142	yteA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
MDDHOLLC_04048	1.05e-101	ytaB	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	membrane
MDDHOLLC_04063	4.34e-80	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_04065	3.34e-06	rapE	-	-	S	ko:K06363	ko02024,map02024	ko00000,ko00001,ko01000	Tetratricopeptide repeat
MDDHOLLC_04067	8.31e-09	-	-	-	L	-	-	-	Replication protein
MDDHOLLC_04068	6.31e-41	-	-	-	L	-	-	-	Replication protein
MDDHOLLC_04069	8.62e-53	-	-	-	L	-	-	-	RePlication protein
MDDHOLLC_04073	5.2e-33	sipT	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MDDHOLLC_04074	3.88e-99	pre	-	-	D	-	-	-	plasmid recombination enzyme
MDDHOLLC_04077	4.34e-80	-	-	-	K	-	-	-	Transcriptional regulator
MDDHOLLC_04079	2.45e-18	-	-	-	S	-	-	-	Tetratricopeptide repeat
MDDHOLLC_04080	3.34e-06	rapE	-	-	S	ko:K06363	ko02024,map02024	ko00000,ko00001,ko01000	Tetratricopeptide repeat
MDDHOLLC_04081	3.31e-30	rapE	-	-	S	ko:K06363	ko02024,map02024	ko00000,ko00001,ko01000	Tetratricopeptide repeat
MDDHOLLC_04082	2.8e-51	-	-	-	L	-	-	-	Replication protein
MDDHOLLC_04083	8.62e-53	-	-	-	L	-	-	-	RePlication protein
MDDHOLLC_04088	5.2e-33	sipT	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MDDHOLLC_04089	1.04e-19	pre	-	-	D	-	-	-	plasmid recombination enzyme