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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
BIGIONGN_00005	1.81e-36	-	-	-	-	-	-	-	-
BIGIONGN_00007	6.28e-128	-	-	-	-	-	-	-	-
BIGIONGN_00008	6.26e-214	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
BIGIONGN_00009	0.0	-	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
BIGIONGN_00010	2.62e-204	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
BIGIONGN_00011	0.0	-	-	-	K	ko:K03491	-	ko00000,ko03000	transcriptional regulator, MtlR
BIGIONGN_00012	2.11e-89	-	-	-	J	-	-	-	L-PSP family endoribonuclease
BIGIONGN_00013	3.42e-297	-	-	-	F	-	-	-	Belongs to the Nudix hydrolase family
BIGIONGN_00014	2.77e-94	-	-	-	S	ko:K04750	-	ko00000	3-demethylubiquinone-9 3-methyltransferase
BIGIONGN_00015	3.25e-97	-	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_00016	7.01e-131	azlC	-	-	E	-	-	-	AzlC protein
BIGIONGN_00017	1.98e-65	azlD	-	-	E	-	-	-	Branched-chain amino acid transport protein (AzlD)
BIGIONGN_00018	2.54e-88	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
BIGIONGN_00020	5.22e-75	-	-	-	K	ko:K03892	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGIONGN_00021	3.78e-97	-	-	-	K	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
BIGIONGN_00022	0.0	-	-	-	L	-	-	-	ABC transporter
BIGIONGN_00023	1.06e-167	-	-	-	C	-	-	-	Oxidoreductase NAD-binding domain
BIGIONGN_00024	5.32e-285	-	-	-	EGP	-	-	-	Transmembrane secretion effector
BIGIONGN_00025	1.14e-255	-	-	-	K	-	-	-	ArsR family transcriptional regulator
BIGIONGN_00026	2.4e-86	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGIONGN_00027	8.34e-255	ycsA	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Tartrate dehydrogenase
BIGIONGN_00028	9.03e-153	ydhC	-	-	K	-	-	-	FCD
BIGIONGN_00029	7.62e-216	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
BIGIONGN_00031	3.41e-303	oxdD	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
BIGIONGN_00034	2.2e-291	ydfA	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIGIONGN_00035	2.84e-72	arsR	-	-	K	ko:K03892,ko:K22043	-	ko00000,ko03000	transcriptional
BIGIONGN_00036	1.2e-101	ydeB	-	-	K	ko:K07736	-	ko00000,ko03000	Transcription factor
BIGIONGN_00037	7.28e-42	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock
BIGIONGN_00038	6.04e-220	mviM3	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_00039	6.34e-183	-	-	-	S	-	-	-	TraX protein
BIGIONGN_00040	2.53e-127	yrkC	-	-	G	-	-	-	Cupin domain
BIGIONGN_00041	1.62e-60	-	-	-	KQ	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_00042	3e-121	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
BIGIONGN_00043	0.0	-	-	-	S	ko:K06994,ko:K11625	ko02020,map02020	ko00000,ko00001	drug exporters of the RND superfamily
BIGIONGN_00044	1.65e-23	-	-	-	K	-	-	-	transcriptional regulator
BIGIONGN_00052	1.4e-114	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
BIGIONGN_00053	3.43e-13	-	-	-	-	-	-	-	-
BIGIONGN_00054	0.0	tex	-	-	K	ko:K06959	-	ko00000	COG2183 Transcriptional accessory protein
BIGIONGN_00055	7.84e-152	rsbX	3.1.3.3	-	KT	ko:K05518	-	ko00000,ko01000,ko03021	Sigma factor PP2C-like phosphatases
BIGIONGN_00056	1.49e-180	sigB	-	-	K	ko:K03090	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_00057	9.7e-109	rsbW	2.7.11.1	-	T	ko:K04757	-	ko00000,ko01000,ko01001,ko03021	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
BIGIONGN_00058	8.36e-72	rsbV	-	-	T	ko:K04749	-	ko00000,ko03021	Belongs to the anti-sigma-factor antagonist family
BIGIONGN_00059	1.25e-238	rsbU	3.1.3.3	-	KT	ko:K07315	-	ko00000,ko01000,ko03021	phosphatase
BIGIONGN_00060	3.52e-96	rsbT	2.7.11.1	-	T	ko:K17752	-	ko00000,ko01000,ko01001,ko03021	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
BIGIONGN_00061	2.69e-70	rsbS	-	-	T	ko:K17762	-	ko00000,ko03021	antagonist
BIGIONGN_00062	1.32e-184	rsbR	-	-	T	ko:K17763	-	ko00000,ko03021	Positive regulator of sigma-B
BIGIONGN_00063	1.53e-74	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
BIGIONGN_00064	4.38e-35	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
BIGIONGN_00065	2.38e-293	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIGIONGN_00066	3.58e-239	ydcC	-	-	M	-	-	-	COG2834 Outer membrane lipoprotein-sorting protein
BIGIONGN_00067	1.69e-77	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
BIGIONGN_00068	7.1e-175	ydcA	-	-	S	-	-	-	membrane protein (homolog of Drosophila rhomboid)
BIGIONGN_00069	8.21e-132	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIGIONGN_00070	0.0	yqgS	2.7.8.20	-	M	ko:K01138,ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
BIGIONGN_00071	7.76e-182	yodJ	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
BIGIONGN_00072	5.02e-63	-	-	-	-	-	-	-	-
BIGIONGN_00073	1.29e-142	-	-	-	S	-	-	-	Integral membrane protein
BIGIONGN_00074	2.5e-279	-	-	-	S	ko:K09927	-	ko00000	Winged helix DNA-binding domain
BIGIONGN_00075	7.18e-181	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_00076	9.28e-249	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_00077	8.53e-247	-	-	-	G	-	-	-	Xylose isomerase
BIGIONGN_00078	3.61e-208	-	-	-	S	-	-	-	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BIGIONGN_00079	7.98e-80	-	-	-	P	ko:K05571	-	ko00000,ko02000	COG1320 Multisubunit Na H antiporter, MnhG subunit
BIGIONGN_00080	2.23e-51	mnhF2	-	-	P	ko:K05570	-	ko00000,ko02000	Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_00081	2.82e-111	mnhE2	-	-	P	ko:K05569	-	ko00000,ko02000	Na+/H+ ion antiporter subunit
BIGIONGN_00082	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_00083	1.85e-66	mnhC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_00084	6.87e-88	mnhB2	-	-	P	ko:K05566	-	ko00000,ko02000	antiporter activity
BIGIONGN_00085	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
BIGIONGN_00086	6.16e-168	-	-	-	T	-	-	-	Universal stress protein family
BIGIONGN_00087	5.35e-145	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
BIGIONGN_00088	4.14e-79	hxlR	-	-	K	-	-	-	transcriptional
BIGIONGN_00089	1.84e-237	ykfD	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00090	5.84e-223	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
BIGIONGN_00091	3.15e-228	ykfA	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
BIGIONGN_00092	0.0	dppE	-	-	E	ko:K16199	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_00093	3.3e-235	dppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00094	1e-220	dppC	-	-	EP	ko:K16201	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00095	6.94e-209	dppB	-	-	P	ko:K16200	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00096	5.06e-194	dppA	-	-	E	ko:K16203	-	ko00000,ko01000,ko01002	D-aminopeptidase
BIGIONGN_00097	2.52e-301	-	2.7.13.3	-	T	ko:K07706,ko:K07717	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase-like ATPases
BIGIONGN_00098	2.15e-203	-	-	-	T	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	YcbB domain
BIGIONGN_00099	8.58e-140	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_00100	4.65e-141	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_00101	5.66e-191	glnH	-	-	ET	ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
BIGIONGN_00102	3.02e-170	glnQ	-	-	E	ko:K09972,ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
BIGIONGN_00103	2.05e-203	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	-transporter
BIGIONGN_00104	1.68e-257	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconolactonase
BIGIONGN_00105	3.15e-257	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
BIGIONGN_00106	1.98e-295	yukF	-	-	QT	-	-	-	Transcriptional regulator
BIGIONGN_00107	1.07e-205	sseA	2.8.1.1, 2.8.1.2	-	P	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	ko00000,ko00001,ko01000	sulfurtransferase
BIGIONGN_00108	0.0	-	-	-	E	ko:K03294,ko:K14052	-	ko00000,ko02000	Amino acid permease
BIGIONGN_00109	2.26e-147	cwlK	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	Peptidase M15B and M15C DD-carboxypeptidase VanY endolysin
BIGIONGN_00110	2.23e-298	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
BIGIONGN_00111	2.91e-256	aprE	3.4.21.62	-	O	ko:K01342	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
BIGIONGN_00113	1.32e-289	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIGIONGN_00114	1.13e-222	yfhM	3.8.1.5	-	S	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Alpha beta hydrolase
BIGIONGN_00115	6.79e-181	-	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
BIGIONGN_00116	1.8e-226	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
BIGIONGN_00117	1.35e-169	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIGIONGN_00118	7.78e-125	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
BIGIONGN_00119	4.31e-166	-	-	-	-	ko:K06336	-	ko00000,ko01002	-
BIGIONGN_00120	7.18e-121	sipW	3.4.21.89	-	U	ko:K13280	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase
BIGIONGN_00121	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
BIGIONGN_00122	9.15e-200	hisJ3	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	PHP domain
BIGIONGN_00123	5.11e-241	qor	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
BIGIONGN_00124	9.48e-150	ppiB	5.2.1.8	-	O	ko:K01802,ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIGIONGN_00125	1.11e-166	-	-	-	-	-	-	-	-
BIGIONGN_00126	7.97e-251	yetN	-	-	S	-	-	-	Protein of unknown function (DUF3900)
BIGIONGN_00127	2.22e-256	-	-	-	KT	ko:K02647	-	ko00000,ko03000	Sugar diacid utilization regulator
BIGIONGN_00128	5.74e-265	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
BIGIONGN_00129	4.21e-105	-	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIGIONGN_00130	1.98e-186	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
BIGIONGN_00131	1.16e-107	yvbK	-	-	K	-	-	-	acetyltransferase
BIGIONGN_00132	1.18e-311	-	-	-	EK	-	-	-	Alanine-glyoxylate amino-transferase
BIGIONGN_00133	1.47e-116	-	3.1.1.29	-	K	ko:K01056	-	ko00000,ko01000,ko03012	-acetyltransferase
BIGIONGN_00134	2.33e-74	-	-	-	-	-	-	-	-
BIGIONGN_00135	2.16e-99	-	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
BIGIONGN_00136	3.13e-282	mgtE	-	-	P	ko:K06213	-	ko00000,ko02000	Acts as a magnesium transporter
BIGIONGN_00137	2.08e-138	desR	-	-	T	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
BIGIONGN_00138	1.93e-264	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_00139	7.66e-251	des	1.14.19.23, 1.14.19.45	-	I	ko:K10255	ko02020,map02020	ko00000,ko00001,ko01000,ko01004	fatty acid desaturase
BIGIONGN_00140	1.8e-218	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00141	0.0	melA	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
BIGIONGN_00142	4.54e-144	apl	3.1.3.1	-	S	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	SNARE associated Golgi protein
BIGIONGN_00143	7.3e-131	yvrI	-	-	K	ko:K03093	-	ko00000,ko03021	RNA polymerase
BIGIONGN_00144	1.14e-52	-	-	-	-	-	-	-	-
BIGIONGN_00145	7.53e-206	ytcP1	-	-	U	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00146	9.97e-221	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00147	6.3e-292	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
BIGIONGN_00148	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_00149	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00150	7.08e-166	-	-	-	S	-	-	-	YwiC-like protein
BIGIONGN_00151	0.0	narK	-	-	P	ko:K02575,ko:K10850	ko00910,ko02020,map00910,map02020	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
BIGIONGN_00152	8.71e-148	nreC	-	-	T	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
BIGIONGN_00153	1.56e-254	nreB	2.7.13.3	-	T	ko:K07683,ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
BIGIONGN_00154	1.45e-108	nreA	-	-	T	ko:K10851	ko02020,map02020	ko00000,ko00001	phosphoenolpyruvate-protein phosphotransferase activity
BIGIONGN_00155	9.42e-163	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	nitrate reductase, gamma subunit
BIGIONGN_00156	4.77e-151	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	Nitrate reductase delta subunit
BIGIONGN_00157	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase, beta
BIGIONGN_00158	0.0	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIGIONGN_00159	3.29e-299	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
BIGIONGN_00160	0.0	ptsG	2.7.1.199, 2.7.1.208	-	G	ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00161	8.63e-154	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIGIONGN_00162	3.12e-181	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGIONGN_00163	1.7e-106	-	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_00164	5.98e-116	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGIONGN_00165	0.0	-	-	-	Q	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
BIGIONGN_00166	1.01e-167	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
BIGIONGN_00172	1.54e-221	-	-	-	G	-	-	-	Glycoside hydrolase family 16
BIGIONGN_00175	2.77e-66	-	-	-	-	-	-	-	-
BIGIONGN_00180	1.61e-183	-	-	-	S	-	-	-	nuclease activity
BIGIONGN_00181	3.83e-104	-	-	-	-	-	-	-	-
BIGIONGN_00182	4.05e-64	-	-	-	-	-	-	-	-
BIGIONGN_00183	4.22e-60	-	-	-	-	-	-	-	-
BIGIONGN_00184	2.51e-93	-	-	-	S	-	-	-	Family of unknown function (DUF5383)
BIGIONGN_00185	0.0	yueB	-	-	S	-	-	-	domain protein
BIGIONGN_00186	0.0	essC	-	-	D	ko:K03466	-	ko00000,ko03036	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
BIGIONGN_00187	5.39e-278	essB	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukC
BIGIONGN_00188	7.61e-52	yukD	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukD
BIGIONGN_00189	3.62e-65	esxA	-	-	S	-	-	-	Belongs to the WXG100 family
BIGIONGN_00190	3.86e-204	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00191	9.01e-198	M1-465	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00192	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00193	6.07e-223	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00194	7.14e-188	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
BIGIONGN_00195	2.79e-195	ydeO	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
BIGIONGN_00196	4.65e-182	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_00197	0.0	hscC	-	-	O	ko:K04045	-	ko00000,ko03110	Hsp70 protein
BIGIONGN_00198	0.0	-	-	-	O	-	-	-	DnaJ molecular chaperone homology domain
BIGIONGN_00200	8.26e-292	-	-	-	G	-	-	-	Metalloenzyme superfamily
BIGIONGN_00201	3.3e-281	-	-	-	E	-	-	-	Alanine racemase, N-terminal domain
BIGIONGN_00202	3.72e-262	-	-	-	E	-	-	-	Cys/Met metabolism PLP-dependent enzyme
BIGIONGN_00203	6.07e-223	php	-	-	S	ko:K07048	-	ko00000	Phosphotriesterase family
BIGIONGN_00204	3.44e-283	-	-	-	S	-	-	-	Protein of unknown function
BIGIONGN_00205	1.98e-76	-	-	-	S	-	-	-	Protein of unknown function DUF2620
BIGIONGN_00206	9.89e-76	-	-	-	S	-	-	-	PRD domain
BIGIONGN_00207	1.99e-207	-	-	-	P	-	-	-	YhfZ C-terminal domain
BIGIONGN_00208	7.63e-249	-	-	-	G	-	-	-	Acyltransferase family
BIGIONGN_00209	1.51e-161	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIGIONGN_00210	0.0	argE	-	-	E	ko:K20895	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Acetylornithine deacetylase
BIGIONGN_00211	0.0	-	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
BIGIONGN_00212	6.33e-167	-	-	-	T	-	-	-	Response regulator receiver domain
BIGIONGN_00213	2.9e-292	citH	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
BIGIONGN_00215	4.22e-293	lacE3	-	-	G	ko:K10240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 1
BIGIONGN_00216	8.82e-213	cebF	-	-	P	ko:K10189,ko:K10241,ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
BIGIONGN_00217	6.65e-196	araQ5	-	-	P	ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
BIGIONGN_00218	1.98e-285	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	GntP family permease
BIGIONGN_00219	3.07e-240	pdxA	1.1.1.408, 1.1.1.409	-	H	ko:K22024	-	ko00000,ko01000	Belongs to the PdxA family
BIGIONGN_00220	8.5e-303	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
BIGIONGN_00221	4.11e-173	-	-	-	K	-	-	-	DeoR C terminal sensor domain
BIGIONGN_00222	0.0	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
BIGIONGN_00223	2.25e-285	gerAC1	-	-	S	ko:K06297	-	ko00000	spore germination
BIGIONGN_00225	2.87e-269	-	-	-	E	ko:K06296	-	ko00000,ko02000	Spore germination protein
BIGIONGN_00226	2.93e-89	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
BIGIONGN_00227	7.22e-205	kynA	1.13.11.11	-	E	ko:K00453	ko00380,ko01100,map00380,map01100	ko00000,ko00001,ko00002,ko01000	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety
BIGIONGN_00228	3.44e-153	kynB	3.5.1.9	-	S	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BIGIONGN_00229	0.0	kynU	3.7.1.3	-	E	ko:K01556	ko00380,ko01100,map00380,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively
BIGIONGN_00230	1.03e-262	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
BIGIONGN_00231	1.13e-290	ybfB	-	-	G	-	-	-	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_00232	6.08e-73	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
BIGIONGN_00233	9.88e-65	-	-	-	S	-	-	-	Family of unknown function (DUF5391)
BIGIONGN_00234	0.0	chiA	3.2.1.14	GH18	G	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Glycoside Hydrolase Family 18
BIGIONGN_00235	6.12e-179	ybgA	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
BIGIONGN_00236	1.24e-179	celCD	2.7.1.196, 2.7.1.205, 3.5.1.105	-	G	ko:K02759,ko:K03478	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides
BIGIONGN_00237	0.0	-	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
BIGIONGN_00238	2.9e-310	ywbA	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGIONGN_00239	1.82e-71	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00240	1.21e-59	licB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00241	9.43e-172	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
BIGIONGN_00242	1.88e-125	-	-	-	-	-	-	-	-
BIGIONGN_00243	5.3e-215	-	-	-	P	-	-	-	Arsenic resistance protein
BIGIONGN_00244	2.28e-242	ybcL	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
BIGIONGN_00245	2.38e-133	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_00246	1.86e-134	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
BIGIONGN_00247	6.3e-195	-	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Tartrate dehydrogenase
BIGIONGN_00248	1.69e-199	-	-	-	P	ko:K14445	-	ko00000,ko02000	Sodium:sulfate symporter transmembrane region
BIGIONGN_00249	1.98e-75	-	-	-	K	-	-	-	FCD
BIGIONGN_00250	4.34e-199	yjmF	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_00251	1.13e-276	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
BIGIONGN_00252	1.05e-248	yjmD	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
BIGIONGN_00253	0.0	-	-	-	C	ko:K13796	-	ko00000	COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit
BIGIONGN_00254	1.89e-254	icd	1.1.1.41, 1.1.1.42, 1.1.1.85	-	CE	ko:K00030,ko:K00031,ko:K00052	ko00020,ko00290,ko00480,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate/isopropylmalate dehydrogenase
BIGIONGN_00255	3.92e-215	yraN	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00256	2.11e-271	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
BIGIONGN_00257	0.0	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctA family
BIGIONGN_00258	9.21e-89	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
BIGIONGN_00259	1.1e-278	yraM	-	-	S	-	-	-	PrpF protein
BIGIONGN_00260	1.47e-79	-	-	-	K	-	-	-	GntR family transcriptional regulator
BIGIONGN_00261	1.25e-204	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_00262	1.56e-22	-	-	-	-	-	-	-	-
BIGIONGN_00263	0.0	cysI	1.8.1.2, 1.8.7.1	-	P	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
BIGIONGN_00264	0.0	cysJ	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIGIONGN_00265	8.66e-141	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
BIGIONGN_00266	1.19e-185	cbiX	4.99.1.3	-	C	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	CbiX
BIGIONGN_00267	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
BIGIONGN_00268	1.03e-144	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
BIGIONGN_00269	1.14e-235	cysP	-	-	P	ko:K16331	-	ko00000,ko02000	phosphate transporter
BIGIONGN_00270	2.13e-279	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
BIGIONGN_00271	3.86e-182	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
BIGIONGN_00272	4.7e-271	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
BIGIONGN_00273	1.58e-100	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_00274	4.35e-238	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_00275	1.73e-253	-	-	-	S	-	-	-	oxidoreductase
BIGIONGN_00276	3.2e-287	-	1.1.1.18, 1.1.1.369, 1.1.1.371	-	S	ko:K00010,ko:K16044	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_00277	9.04e-159	kdgR	-	-	K	-	-	-	FCD
BIGIONGN_00278	1.86e-210	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
BIGIONGN_00279	7.11e-124	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGIONGN_00280	1.01e-171	ssuB	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
BIGIONGN_00281	1e-174	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
BIGIONGN_00282	1.31e-267	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
BIGIONGN_00283	1.05e-229	-	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_00284	6.32e-122	ssuE	1.5.1.38, 1.5.1.45	-	S	ko:K00299,ko:K16902	ko00380,ko00740,ko00920,ko01100,map00380,map00740,map00920,map01100	ko00000,ko00001,ko01000	FMN reductase
BIGIONGN_00285	1.5e-09	-	-	-	S	-	-	-	Uncharacterized small protein (DUF2292)
BIGIONGN_00286	4.12e-104	-	-	-	-	-	-	-	-
BIGIONGN_00287	6.94e-160	yflK	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_00288	2.45e-215	-	2.7.1.196, 2.7.1.205	-	K	ko:K02760,ko:K20480	ko00500,ko02024,ko02060,map00500,map02024,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	sequence-specific DNA binding
BIGIONGN_00289	5.07e-299	gntT	-	-	EG	-	-	-	gluconate transmembrane transporter activity
BIGIONGN_00291	1.19e-314	-	-	-	-	-	-	-	-
BIGIONGN_00292	0.0	yngI	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
BIGIONGN_00293	1.2e-59	M1-594	-	-	S	-	-	-	Thiamine-binding protein
BIGIONGN_00295	6.09e-275	chrA	-	-	P	ko:K07240	-	ko00000,ko02000	chromate transporter, chromate ion transporter
BIGIONGN_00296	2.4e-42	-	5.3.2.6	-	S	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Tautomerase enzyme
BIGIONGN_00297	1.61e-274	-	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
BIGIONGN_00298	3.63e-220	-	-	-	E	-	-	-	Thermophilic metalloprotease (M29)
BIGIONGN_00299	9.74e-146	-	-	-	E	ko:K14591	-	ko00000	AroM protein
BIGIONGN_00300	6.01e-217	-	-	-	S	-	-	-	Protein of unknown function (DUF1177)
BIGIONGN_00301	8.2e-245	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
BIGIONGN_00302	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
BIGIONGN_00303	1.54e-141	-	-	-	E	-	-	-	Asp/Glu/Hydantoin racemase
BIGIONGN_00304	0.0	-	-	-	KT	ko:K09684	-	ko00000,ko03000	PucR C-terminal helix-turn-helix domain
BIGIONGN_00305	7.22e-283	yrbE	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_00306	5.09e-161	-	-	-	S	ko:K09992	-	ko00000	Trehalose utilisation
BIGIONGN_00307	3.43e-281	xylR5	-	-	GK	-	-	-	ROK family
BIGIONGN_00308	4.31e-258	mro	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Converts alpha-aldose to the beta-anomer
BIGIONGN_00309	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	xylulose kinase
BIGIONGN_00310	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
BIGIONGN_00311	5.63e-176	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00312	5.79e-309	yodQ	3.5.1.16, 3.5.1.18	-	E	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetylornithine deacetylase
BIGIONGN_00313	2.38e-225	-	-	-	S	-	-	-	Protein of unknown function (DUF1177)
BIGIONGN_00314	1.5e-242	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00315	1.36e-242	-	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00316	3.26e-197	-	-	-	EP	ko:K02034,ko:K13891	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00317	4.39e-219	-	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00318	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_00319	4.36e-263	-	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
BIGIONGN_00320	4.33e-281	hutI	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
BIGIONGN_00321	1.94e-45	-	-	-	D	-	-	-	nuclear chromosome segregation
BIGIONGN_00322	3.82e-255	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
BIGIONGN_00323	1.13e-158	-	-	-	S	-	-	-	Protein of unknown function, DUF624
BIGIONGN_00324	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00325	1.9e-197	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
BIGIONGN_00326	5.62e-226	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00327	0.0	aguA	3.2.1.139	-	G	ko:K01235	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 67 family
BIGIONGN_00328	0.0	xynB	3.2.1.37	GH43	G	ko:K01198	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
BIGIONGN_00330	2.97e-220	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_00331	1.03e-241	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGIONGN_00332	3.91e-145	-	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
BIGIONGN_00333	6.67e-202	metQ_3	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
BIGIONGN_00334	3.59e-284	hmrA	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
BIGIONGN_00335	1.42e-235	-	-	-	S	-	-	-	Putative nucleotide-binding of sugar-metabolising enzyme
BIGIONGN_00336	7.1e-162	garR	1.1.1.60	-	I	ko:K00042	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
BIGIONGN_00337	4.81e-228	-	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
BIGIONGN_00338	3.69e-131	ybbH	-	-	K	-	-	-	RpiR family transcriptional regulator
BIGIONGN_00340	5.17e-273	-	-	-	G	-	-	-	Transmembrane secretion effector
BIGIONGN_00341	9.37e-212	-	4.1.3.4	-	E	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA lyase
BIGIONGN_00342	3.56e-152	-	-	-	K	-	-	-	FCD domain
BIGIONGN_00343	3.24e-292	bbsF_2	2.8.3.16	-	C	ko:K07749	-	ko00000,ko01000	acyl-CoA transferases carnitine dehydratase
BIGIONGN_00344	8.92e-29	-	-	-	-	-	-	-	-
BIGIONGN_00345	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
BIGIONGN_00346	2.72e-194	-	-	-	-	-	-	-	-
BIGIONGN_00347	1.08e-123	-	-	-	-	-	-	-	-
BIGIONGN_00348	2.83e-144	-	-	-	-	-	-	-	-
BIGIONGN_00349	0.0	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_00352	0.0	-	-	-	V	-	-	-	SNF2 family N-terminal domain
BIGIONGN_00353	1.31e-167	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
BIGIONGN_00354	1.52e-119	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
BIGIONGN_00355	1.2e-144	wrbA	1.6.5.2	-	S	ko:K03809	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Belongs to the WrbA family
BIGIONGN_00356	2.25e-100	-	-	-	S	-	-	-	VanZ like family
BIGIONGN_00357	1.26e-265	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
BIGIONGN_00358	1.9e-145	-	-	-	S	-	-	-	Predicted membrane protein (DUF2306)
BIGIONGN_00359	4.56e-244	-	-	-	K	-	-	-	DJ-1/PfpI family
BIGIONGN_00360	4.32e-163	-	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_00361	3.69e-314	-	2.7.13.3	-	T	ko:K02484	-	ko00000,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
BIGIONGN_00362	2.08e-160	-	-	-	S	ko:K02351	-	ko00000	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
BIGIONGN_00363	2.4e-116	-	-	-	S	-	-	-	Predicted membrane protein (DUF2243)
BIGIONGN_00364	9.54e-203	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
BIGIONGN_00365	3.46e-290	dgoD	4.2.1.6	-	M	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
BIGIONGN_00366	8.33e-137	-	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
BIGIONGN_00367	2.11e-223	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
BIGIONGN_00368	2.98e-165	-	-	-	K	-	-	-	helix_turn_helix isocitrate lyase regulation
BIGIONGN_00369	6.07e-144	ycsK	-	-	E	-	-	-	anatomical structure formation involved in morphogenesis
BIGIONGN_00370	3.63e-309	VCP	-	-	O	-	-	-	AAA domain (dynein-related subfamily)
BIGIONGN_00371	1.13e-36	-	-	-	-	-	-	-	-
BIGIONGN_00372	6.43e-55	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
BIGIONGN_00373	4.13e-314	-	-	-	M	-	-	-	Glycosyltransferase like family 2
BIGIONGN_00374	3.19e-35	ybbJ	-	-	K	-	-	-	acetyltransferase
BIGIONGN_00375	7.2e-44	ybbJ	-	-	J	-	-	-	acetyltransferase
BIGIONGN_00376	0.0	-	1.1.1.136	-	M	ko:K13015	ko00520,map00520	ko00000,ko00001,ko01000,ko01005	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIGIONGN_00377	5.27e-169	-	-	-	M	-	-	-	Glycosyl transferase family 2
BIGIONGN_00378	4.27e-222	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
BIGIONGN_00379	2.94e-171	-	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	transferase activity, transferring glycosyl groups
BIGIONGN_00380	5.28e-202	-	-	-	-	-	-	-	-
BIGIONGN_00381	4.39e-244	-	-	-	M	-	-	-	Glycosyl transferases group 1
BIGIONGN_00382	2.77e-221	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	GDP-mannose 4,6 dehydratase
BIGIONGN_00383	7.95e-133	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIGIONGN_00384	5.96e-284	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_00385	6.1e-116	-	-	-	S	-	-	-	Uncharacterised protein family UPF0066
BIGIONGN_00387	2.05e-178	yafE	-	-	Q	-	-	-	methyltransferase
BIGIONGN_00389	0.0	-	1.3.98.3	-	H	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of porphyrin-containing compound
BIGIONGN_00390	0.0	-	-	-	I	-	-	-	radical SAM domain protein
BIGIONGN_00392	2.53e-05	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
BIGIONGN_00393	1.39e-21	-	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
BIGIONGN_00394	4.23e-117	ykoJ	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
BIGIONGN_00395	4.95e-160	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
BIGIONGN_00396	3.02e-310	ykoH	-	-	T	-	-	-	Histidine kinase
BIGIONGN_00397	1.17e-106	ykoG	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_00398	3.29e-181	-	-	-	S	-	-	-	carbohydrate derivative metabolic process
BIGIONGN_00399	4.65e-167	frlR3	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
BIGIONGN_00400	2.67e-292	-	-	-	JM	-	-	-	Bacterial transferase hexapeptide (six repeats)
BIGIONGN_00401	1.03e-126	-	-	-	M	-	-	-	3D domain
BIGIONGN_00402	2.43e-88	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
BIGIONGN_00403	2.55e-256	ypcG	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_00404	4.62e-170	ytcP	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00405	1.36e-171	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00406	1.54e-124	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
BIGIONGN_00407	7.49e-148	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_00408	2.93e-13	-	-	-	S	-	-	-	Protein of unknown function, DUF624
BIGIONGN_00409	4e-236	-	-	-	S	ko:K09704	-	ko00000	Glycosyl hydrolase
BIGIONGN_00410	3.36e-313	-	2.3.1.204, 3.2.1.24	GH38	G	ko:K01191,ko:K16869	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
BIGIONGN_00411	1.94e-233	-	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 85
BIGIONGN_00412	0.0	-	3.2.1.24	GH38	G	ko:K01191	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
BIGIONGN_00413	3.86e-263	-	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Glycosyl hydrolase family 1
BIGIONGN_00414	1.74e-110	-	-	-	-	-	-	-	-
BIGIONGN_00415	1.27e-105	-	-	-	K	-	-	-	Bacterial transcription activator, effector binding domain
BIGIONGN_00416	4.18e-135	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_00417	3.48e-78	-	-	-	K	-	-	-	TetR family transcriptional regulator
BIGIONGN_00418	0.0	licR	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
BIGIONGN_00419	0.0	gmuD	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGIONGN_00420	5.36e-66	celC	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00421	1.37e-305	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGIONGN_00422	3.7e-60	ydhM	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00423	2.43e-175	yybG	-	-	S	-	-	-	Pentapeptide repeat-containing protein
BIGIONGN_00424	1.47e-115	-	-	-	V	-	-	-	COG1680 Beta-lactamase class C and other penicillin binding proteins
BIGIONGN_00425	4.66e-87	-	-	-	F	-	-	-	Cytidine and deoxycytidylate deaminase zinc-binding region
BIGIONGN_00426	3.53e-275	yycB1	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
BIGIONGN_00427	7.98e-156	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
BIGIONGN_00428	1.05e-156	ycbG	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
BIGIONGN_00429	3.23e-218	ycbC	4.2.1.41	-	EM	ko:K01707	ko00053,ko01100,map00053,map01100	ko00000,ko00001,ko01000	5-dehydro-4-deoxyglucarate dehydratase activity
BIGIONGN_00430	0.0	ycbD	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_00431	6.57e-107	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
BIGIONGN_00432	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
BIGIONGN_00433	2.43e-241	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
BIGIONGN_00434	1.71e-241	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	mannonate dehydratase activity
BIGIONGN_00435	1.22e-70	-	-	-	-	-	-	-	-
BIGIONGN_00436	0.0	-	-	-	-	-	-	-	-
BIGIONGN_00437	1.42e-102	-	-	-	-	-	-	-	-
BIGIONGN_00438	1.26e-137	-	-	-	-	-	-	-	-
BIGIONGN_00439	8.61e-89	-	-	-	F	-	-	-	NUDIX domain
BIGIONGN_00440	1.09e-127	-	-	-	S	-	-	-	Tetratricopeptide repeat
BIGIONGN_00441	1.68e-15	-	-	-	-	-	-	-	-
BIGIONGN_00442	1.12e-303	-	-	-	V	-	-	-	MatE
BIGIONGN_00443	0.0	mcpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
BIGIONGN_00444	2.89e-291	-	-	-	C	ko:K03300	-	ko00000	Citrate transporter
BIGIONGN_00445	2.11e-69	-	-	-	-	-	-	-	-
BIGIONGN_00446	8.23e-305	-	-	-	E	-	-	-	Acyclic terpene utilisation family protein AtuA
BIGIONGN_00447	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
BIGIONGN_00448	5.76e-134	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BIGIONGN_00449	1.2e-203	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BIGIONGN_00450	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
BIGIONGN_00452	1.21e-121	ydaE	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Cupin 2, conserved barrel domain protein
BIGIONGN_00453	7.44e-238	fruA2	-	-	G	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase System
BIGIONGN_00454	6.25e-63	-	2.7.1.202	-	G	ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGIONGN_00455	2.14e-100	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGIONGN_00456	3.06e-204	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
BIGIONGN_00457	0.0	-	-	-	K	ko:K03491	-	ko00000,ko03000	transcriptional regulator, MtlR
BIGIONGN_00458	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
BIGIONGN_00459	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
BIGIONGN_00460	4.36e-284	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
BIGIONGN_00461	4.43e-105	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_00462	3.33e-242	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_00463	1.17e-247	-	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
BIGIONGN_00464	1.52e-209	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00465	0.0	-	-	-	G	ko:K02027,ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00466	3.32e-212	-	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00467	2.45e-182	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00468	5.4e-311	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	O-acetylhomoserine
BIGIONGN_00469	2.79e-135	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
BIGIONGN_00470	0.0	-	-	-	S	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIGIONGN_00471	4.95e-246	-	1.1.1.18, 1.1.1.369, 1.1.1.370	-	S	ko:K00010,ko:K16043	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_00472	2.25e-207	iolJ	4.1.2.13, 4.1.2.29	-	F	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
BIGIONGN_00473	6.31e-252	iolG	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
BIGIONGN_00474	3.02e-226	iolE	4.2.1.44	-	G	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
BIGIONGN_00475	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
BIGIONGN_00476	9.35e-228	iolC	2.7.1.92	-	G	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
BIGIONGN_00477	1.41e-199	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
BIGIONGN_00478	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_00479	2.48e-177	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
BIGIONGN_00480	3.01e-309	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGIONGN_00481	1.47e-130	yvdT_1	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00482	2.06e-78	ykkC_1	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
BIGIONGN_00483	2.37e-62	ykkD_1	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
BIGIONGN_00484	2.49e-239	-	-	-	KTV	ko:K01990	-	ko00000,ko00002,ko02000	LytTr DNA-binding domain
BIGIONGN_00485	3.89e-148	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
BIGIONGN_00486	3.11e-106	-	-	-	S	-	-	-	Putative small multi-drug export protein
BIGIONGN_00488	7.9e-63	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGIONGN_00489	0.0	melA7	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
BIGIONGN_00490	3.63e-253	araH	-	-	G	ko:K10544,ko:K10547	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGIONGN_00491	0.0	araG	3.6.3.17	-	G	ko:K10548	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
BIGIONGN_00492	1.96e-252	chvE	-	-	G	ko:K10546	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_00493	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
BIGIONGN_00494	0.0	araB	2.7.1.16	-	C	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Belongs to the ribulokinase family
BIGIONGN_00495	2.15e-176	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
BIGIONGN_00496	3.27e-276	egsA	1.1.1.261	-	C	ko:K00096	ko00564,map00564	ko00000,ko00001,ko01000	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
BIGIONGN_00497	2.67e-179	araL	-	-	G	ko:K02101	-	ko00000	Haloacid dehalogenase-like hydrolase
BIGIONGN_00498	8.24e-217	rhaR1	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00499	9.7e-223	M1-640	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00500	1.33e-140	-	-	-	S	-	-	-	Protein of unknown function, DUF624
BIGIONGN_00501	4.49e-196	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00502	1.25e-204	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00503	5.82e-311	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00504	0.0	abfA	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	alpha-L-arabinofuranosidase activity
BIGIONGN_00505	1.2e-200	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00506	2.9e-189	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00507	2.66e-310	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00508	0.0	yesW	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
BIGIONGN_00510	1.14e-163	-	-	-	S	-	-	-	L-2-amino-thiazoline-4-carboxylic acid hydrolase
BIGIONGN_00511	1.25e-206	-	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_00512	1.39e-152	ykoG	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_00513	3.3e-298	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
BIGIONGN_00514	2.9e-255	-	-	-	I	-	-	-	Acyltransferase family
BIGIONGN_00515	4.88e-200	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00516	2.9e-225	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00517	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00518	2.34e-265	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
BIGIONGN_00519	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_00520	6.96e-286	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_00521	4.9e-201	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_00522	1.16e-284	-	-	-	EM	-	-	-	Protein of unknown function (DUF993)
BIGIONGN_00523	7.06e-294	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_00524	2.49e-192	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00525	9.68e-291	-	-	-	EGP	ko:K06610	-	ko00000,ko02000	Major facilitator superfamily
BIGIONGN_00526	1.21e-73	rhaM	5.1.3.32	-	G	ko:K03534	-	ko00000,ko01000	Involved in the anomeric conversion of L-rhamnose
BIGIONGN_00527	0.0	yuxG	-	-	IQ	-	-	-	Class II Aldolase and Adducin N-terminal domain
BIGIONGN_00528	0.0	rhaA	2.7.1.5, 5.3.1.14	-	G	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Belongs to the rhamnose isomerase family
BIGIONGN_00529	1.14e-231	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_00530	0.0	-	-	-	E	-	-	-	amino acid
BIGIONGN_00531	6.05e-220	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
BIGIONGN_00532	6.43e-88	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGIONGN_00533	2.9e-154	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_00534	6.82e-183	fabG1	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_00535	1.03e-264	-	-	-	-	-	-	-	-
BIGIONGN_00536	4.08e-137	ykoP	-	-	G	-	-	-	polysaccharide deacetylase
BIGIONGN_00537	2.39e-253	-	1.1.1.361	-	S	ko:K18652	-	ko00000,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_00538	1.56e-230	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_00539	3.96e-166	yhdW	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
BIGIONGN_00540	1.06e-200	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
BIGIONGN_00541	1.33e-226	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00542	1.02e-120	-	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIGIONGN_00543	2.94e-194	-	-	-	G	-	-	-	Haloacid dehalogenase-like hydrolase
BIGIONGN_00544	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00545	7.67e-273	-	-	-	EGP	ko:K08162	-	ko00000,ko02000	Major Facilitator Superfamily
BIGIONGN_00546	2.4e-181	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
BIGIONGN_00547	1.15e-302	ugpB	-	-	G	ko:K02027,ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter substrate-binding protein
BIGIONGN_00548	5.39e-184	ugpE	-	-	P	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter permease
BIGIONGN_00549	5.95e-211	ugpA	-	-	G	ko:K02025,ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
BIGIONGN_00550	4.35e-262	ugpC	3.6.3.20	-	P	ko:K05816,ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00551	0.0	-	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
BIGIONGN_00552	5.99e-308	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BIGIONGN_00553	4.21e-100	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
BIGIONGN_00554	1.6e-249	yneE	-	-	K	-	-	-	Arabinose-binding domain of AraC transcription regulator, N-term
BIGIONGN_00555	4.3e-187	dhrS4	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_00557	1.15e-58	-	-	-	-	-	-	-	-
BIGIONGN_00558	3.23e-298	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_00559	5.3e-49	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
BIGIONGN_00561	7.9e-39	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_00562	6.29e-263	yhfS	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
BIGIONGN_00563	0.0	-	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
BIGIONGN_00564	0.0	alkK	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
BIGIONGN_00566	1.91e-248	-	3.6.3.20	-	P	ko:K05816	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00567	2.4e-190	-	-	-	P	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
BIGIONGN_00568	2.75e-211	-	-	-	G	ko:K02025,ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
BIGIONGN_00569	1.99e-196	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_00570	0.0	-	-	-	G	ko:K02027,ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter substrate-binding protein
BIGIONGN_00571	1.59e-99	ectC	4.2.1.108	-	S	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
BIGIONGN_00572	7.81e-316	ectB	2.6.1.76	-	E	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIGIONGN_00573	1.77e-116	ectA	2.3.1.178	-	K	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	ko00000,ko00001,ko00002,ko01000	L-2,4-diaminobutyric acid acetyltransferase
BIGIONGN_00574	2.63e-90	-	-	-	-	-	-	-	-
BIGIONGN_00575	0.0	-	-	-	EG	ko:K06295	-	ko00000	Bacillus/Clostridium GerA spore germination protein
BIGIONGN_00576	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_00577	1.25e-264	-	-	-	C	ko:K19954	-	ko00000,ko01000	alcohol dehydrogenase
BIGIONGN_00578	1.14e-224	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
BIGIONGN_00579	1.07e-298	-	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
BIGIONGN_00580	1.07e-281	adhB	1.1.1.1, 1.1.1.202	-	C	ko:K00001,ko:K00086	ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
BIGIONGN_00581	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
BIGIONGN_00582	7.43e-29	-	-	-	-	-	-	-	-
BIGIONGN_00583	5.57e-71	fdx5	-	-	C	-	-	-	2Fe-2S iron-sulfur cluster binding domain
BIGIONGN_00584	4.72e-127	-	-	-	S	-	-	-	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BIGIONGN_00586	1.34e-52	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
BIGIONGN_00587	9.27e-209	manA3	3.2.1.78	GH26	G	ko:K01218	ko00051,ko02024,map00051,map02024	ko00000,ko00001,ko01000	Endoglucanase
BIGIONGN_00588	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_00589	3.47e-215	-	-	-	P	ko:K02026,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
BIGIONGN_00590	3.26e-199	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_00591	1.47e-213	-	-	-	GK	-	-	-	ROK family
BIGIONGN_00592	0.0	ydhP	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
BIGIONGN_00593	1.58e-239	purR15	-	-	K	ko:K02529	-	ko00000,ko03000	Bacterial regulatory proteins, lacI family
BIGIONGN_00594	1.34e-256	yleB	4.2.1.126	-	S	ko:K07106,ko:K09963	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Bacterial protein of unknown function (DUF871)
BIGIONGN_00595	3.64e-306	ybbF	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_00596	5.04e-201	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIGIONGN_00597	0.0	-	-	-	K	-	-	-	Propionate catabolism activator
BIGIONGN_00599	4.37e-218	kdgT	-	-	P	ko:K02526	-	ko00000,ko02000	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
BIGIONGN_00600	2.03e-308	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
BIGIONGN_00601	3.05e-235	pdxA	1.1.1.408, 1.1.1.409	-	H	ko:K22024	-	ko00000,ko01000	Belongs to the PdxA family
BIGIONGN_00602	3.25e-190	murR	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00603	0.0	yvcC1	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
BIGIONGN_00604	1.33e-181	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_00605	1.27e-224	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGIONGN_00606	5.97e-241	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_00607	2.53e-107	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_00608	1e-276	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
BIGIONGN_00609	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
BIGIONGN_00611	4.87e-134	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
BIGIONGN_00612	0.0	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BIGIONGN_00613	9.74e-224	yueF	-	-	S	-	-	-	transporter activity
BIGIONGN_00614	2.62e-111	ftnA	1.16.3.2	-	P	ko:K02217	-	ko00000,ko01000	Iron-storage protein
BIGIONGN_00615	4.11e-11	-	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
BIGIONGN_00616	3.19e-127	flaR	-	-	F	-	-	-	topology modulation protein
BIGIONGN_00617	3.5e-272	yutK	-	-	F	ko:K03317	-	ko00000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIGIONGN_00618	2.75e-210	ycgS	-	-	I	-	-	-	alpha/beta hydrolase fold
BIGIONGN_00619	3.84e-153	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
BIGIONGN_00620	0.0	-	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
BIGIONGN_00621	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BIGIONGN_00622	1.92e-56	ylaN	-	-	S	-	-	-	Belongs to the UPF0358 family
BIGIONGN_00623	1.36e-122	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIGIONGN_00624	0.0	ylaK	-	-	T	ko:K07175	-	ko00000	ATPase related to phosphate starvation-inducible protein PhoH
BIGIONGN_00625	1.3e-44	ylaI	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_00626	3.25e-70	ylaH	-	-	S	-	-	-	YlaH-like protein
BIGIONGN_00627	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
BIGIONGN_00628	1.13e-17	-	-	-	S	-	-	-	Family of unknown function (DUF5325)
BIGIONGN_00629	9.56e-212	-	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
BIGIONGN_00630	3.73e-198	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase
BIGIONGN_00631	2.42e-152	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
BIGIONGN_00632	6.3e-55	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
BIGIONGN_00633	0.0	speA	4.1.1.17, 4.1.1.19	-	E	ko:K01581,ko:K01585	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Arginine
BIGIONGN_00634	7.16e-297	-	-	-	O	-	-	-	Peptidase family M48
BIGIONGN_00635	5.93e-174	pdaA_2	3.5.1.104	-	G	ko:K01567,ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
BIGIONGN_00636	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
BIGIONGN_00637	6.88e-89	-	-	-	CO	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	cell redox homeostasis
BIGIONGN_00638	1.7e-207	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00639	3.37e-223	-	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_00640	0.0	appA_2	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_00641	5.5e-238	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00642	3.07e-239	appD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_00643	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
BIGIONGN_00644	6.67e-248	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
BIGIONGN_00645	1.5e-228	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
BIGIONGN_00646	3.83e-256	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
BIGIONGN_00647	5.09e-132	ykyA	-	-	L	-	-	-	Putative cell-wall binding lipoprotein
BIGIONGN_00648	1.8e-33	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
BIGIONGN_00649	2.58e-131	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
BIGIONGN_00650	4.45e-42	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
BIGIONGN_00651	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIGIONGN_00652	6.6e-150	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
BIGIONGN_00653	1.25e-107	ykuV	-	-	CO	-	-	-	thiol-disulfide
BIGIONGN_00654	3.15e-131	ykuU	-	-	O	-	-	-	Alkyl hydroperoxide reductase
BIGIONGN_00655	3.77e-173	ykuT	-	-	M	ko:K22044	-	ko00000,ko02000	Mechanosensitive ion channel
BIGIONGN_00656	1.46e-50	ykuS	-	-	S	-	-	-	Belongs to the UPF0180 family
BIGIONGN_00657	7.99e-276	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
BIGIONGN_00658	2.67e-291	-	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
BIGIONGN_00659	2.79e-115	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
BIGIONGN_00660	5.28e-188	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
BIGIONGN_00661	3.01e-244	-	-	-	T	-	-	-	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGIONGN_00662	2.2e-253	yhdY	-	-	M	ko:K16052	-	ko00000,ko02000	Mechanosensitive ion channel
BIGIONGN_00664	1.92e-126	copC	-	-	S	ko:K07156	-	ko00000,ko02000	CopC domain
BIGIONGN_00665	3.27e-237	ytvI	-	-	S	-	-	-	AI-2E family transporter
BIGIONGN_00666	6.03e-144	yhfK	-	-	GM	-	-	-	NmrA-like family
BIGIONGN_00667	2.19e-290	-	-	-	E	-	-	-	Peptidase family M28
BIGIONGN_00668	1.42e-245	-	-	-	C	-	-	-	Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
BIGIONGN_00670	4.66e-128	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_00671	9.47e-39	copZ	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	Heavy-metal-associated domain
BIGIONGN_00672	1.16e-62	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	transcriptional
BIGIONGN_00673	1.66e-42	-	-	-	-	-	-	-	-
BIGIONGN_00674	1.84e-188	ykrA	-	-	S	-	-	-	hydrolases of the HAD superfamily
BIGIONGN_00676	3.38e-77	-	-	-	-	-	-	-	-
BIGIONGN_00677	2.91e-99	yqiW	-	-	S	-	-	-	Belongs to the UPF0403 family
BIGIONGN_00678	1.05e-291	bkdB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
BIGIONGN_00679	1.63e-233	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
BIGIONGN_00680	2.17e-241	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
BIGIONGN_00681	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
BIGIONGN_00682	3.58e-263	ldh	1.4.1.9	-	E	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
BIGIONGN_00683	0.0	bkdR	-	-	KT	-	-	-	Transcriptional regulator
BIGIONGN_00684	3.32e-48	yqzF	-	-	S	-	-	-	Protein of unknown function (DUF2627)
BIGIONGN_00685	8.46e-154	-	-	-	M	-	-	-	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIGIONGN_00686	8.04e-186	spo0A	-	-	KT	ko:K07699	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
BIGIONGN_00687	5.1e-302	spoIVB	3.4.21.116	-	M	ko:K06399	-	ko00000,ko01000,ko01002	Stage IV sporulation protein B
BIGIONGN_00688	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
BIGIONGN_00689	6.48e-104	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
BIGIONGN_00690	6.65e-193	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
BIGIONGN_00691	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIGIONGN_00692	2.81e-202	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
BIGIONGN_00693	2.03e-47	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
BIGIONGN_00694	0.0	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
BIGIONGN_00695	1.42e-88	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIGIONGN_00696	5.96e-87	yqhY	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_00697	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
BIGIONGN_00698	7.32e-105	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
BIGIONGN_00699	3.08e-74	-	-	-	-	-	-	-	-
BIGIONGN_00700	2.98e-117	spoIIIAH	-	-	S	ko:K06397	-	ko00000	SpoIIIAH-like protein
BIGIONGN_00701	1.05e-146	spoIIIAG	-	-	S	ko:K06396	-	ko00000	stage III sporulation protein AG
BIGIONGN_00702	1.39e-121	spoIIIAF	-	-	S	ko:K06395	-	ko00000	Stage III sporulation protein AF (Spore_III_AF)
BIGIONGN_00703	2.5e-261	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
BIGIONGN_00704	6.3e-54	spoIIIAD	-	-	S	ko:K06393	-	ko00000	Stage III sporulation protein AD
BIGIONGN_00705	1.98e-40	spoIIIAC	-	-	S	ko:K06392	-	ko00000	stage III sporulation protein AC
BIGIONGN_00706	6.16e-110	spoIIIAB	-	-	S	ko:K06391	-	ko00000	Stage III sporulation protein
BIGIONGN_00707	2.02e-218	spoIIIAA	-	-	S	ko:K06390	-	ko00000	stage III sporulation protein AA
BIGIONGN_00708	3.84e-48	yqhV	-	-	S	-	-	-	Protein of unknown function (DUF2619)
BIGIONGN_00709	9.91e-68	-	-	-	S	-	-	-	YfzA-like protein
BIGIONGN_00710	3.54e-128	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIGIONGN_00711	7.96e-127	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIGIONGN_00712	1.61e-250	yqhT	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
BIGIONGN_00713	4.42e-116	yqhR	-	-	S	-	-	-	Conserved membrane protein YqhR
BIGIONGN_00714	2.46e-79	-	-	-	-	-	-	-	-
BIGIONGN_00715	4.2e-213	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
BIGIONGN_00716	6.58e-101	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
BIGIONGN_00717	5.42e-255	splB	4.1.99.14	-	L	ko:K03716	-	ko00000,ko01000	Spore photoproduct lyase
BIGIONGN_00718	1.03e-203	dat	2.6.1.21	-	E	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	ko00000,ko00001,ko01000,ko01007	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
BIGIONGN_00719	0.0	uvrD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGIONGN_00720	6.16e-197	lipM	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
BIGIONGN_00721	9.44e-82	yqhL	-	-	P	-	-	-	COG0607 Rhodanese-related sulfurtransferase
BIGIONGN_00722	0.0	gcvPB	1.4.4.2	-	E	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIGIONGN_00723	0.0	gcvPA	1.4.4.2	-	E	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIGIONGN_00724	6.95e-262	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine
BIGIONGN_00725	0.0	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
BIGIONGN_00726	4.02e-196	yqhG	-	-	S	-	-	-	Bacterial protein YqhG of unknown function
BIGIONGN_00728	7.55e-155	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
BIGIONGN_00729	2.65e-48	B4168_0554	-	-	S	-	-	-	Protein of unknown function (DUF2626)
BIGIONGN_00732	4.4e-106	-	-	-	-	-	-	-	-
BIGIONGN_00734	5.75e-98	-	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	general secretion pathway protein
BIGIONGN_00735	1.22e-64	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
BIGIONGN_00736	3.58e-55	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
BIGIONGN_00746	8.18e-243	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
BIGIONGN_00747	2e-241	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIGIONGN_00748	0.0	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGIONGN_00749	4.39e-97	-	-	-	-	-	-	-	-
BIGIONGN_00750	1.88e-113	cotX	-	-	S	ko:K06342	-	ko00000	Spore Coat Protein X and V domain
BIGIONGN_00751	6.94e-07	-	-	-	-	-	-	-	-
BIGIONGN_00753	1.77e-176	-	-	-	-	-	-	-	-
BIGIONGN_00754	3.67e-164	-	-	-	-	-	-	-	-
BIGIONGN_00755	1.91e-186	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
BIGIONGN_00756	1.07e-79	-	-	-	S	-	-	-	Protein of unknown function (DUF1360)
BIGIONGN_00757	1.74e-178	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
BIGIONGN_00758	4.61e-220	rluD	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
BIGIONGN_00759	5.27e-193	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIGIONGN_00760	1.02e-142	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	GTP pyrophosphokinase
BIGIONGN_00761	3.74e-82	yjbL	-	-	S	-	-	-	Belongs to the UPF0738 family
BIGIONGN_00762	1.37e-128	yjbK	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_00763	4.71e-142	yjbJ	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
BIGIONGN_00764	1.67e-95	yjbI	-	-	S	ko:K06886	-	ko00000	COG2346 Truncated hemoglobins
BIGIONGN_00765	2.68e-223	yjbH	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIGIONGN_00767	5.05e-303	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
BIGIONGN_00768	5.5e-148	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
BIGIONGN_00769	2.03e-87	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
BIGIONGN_00771	2.05e-127	yjbC	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_00772	1.58e-301	-	-	-	S	-	-	-	Putative glycosyl hydrolase domain
BIGIONGN_00773	1.83e-12	yoeD	-	-	G	-	-	-	Helix-turn-helix domain
BIGIONGN_00774	1.5e-144	yplQ	-	-	S	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
BIGIONGN_00775	1.5e-128	yueE	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
BIGIONGN_00776	6.02e-135	-	-	-	CO	-	-	-	Redoxin
BIGIONGN_00778	4.68e-234	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
BIGIONGN_00779	1.94e-15	-	-	-	-	-	-	-	-
BIGIONGN_00780	8.42e-185	yjbA	-	-	S	-	-	-	Belongs to the UPF0736 family
BIGIONGN_00781	4.9e-200	yjaZ	-	-	O	-	-	-	Zn-dependent protease
BIGIONGN_00782	1.49e-176	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	protein conserved in bacteria
BIGIONGN_00783	1.82e-229	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
BIGIONGN_00784	2.77e-172	ykwD	-	-	J	-	-	-	protein with SCP PR1 domains
BIGIONGN_00785	1.16e-134	-	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell Wall Hydrolase
BIGIONGN_00787	0.0	-	2.7.7.19, 2.7.7.72	-	J	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	Poly A polymerase head domain
BIGIONGN_00788	1.28e-294	fabF	2.3.1.179	-	I	ko:K09458,ko:K14660	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
BIGIONGN_00789	4.37e-214	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIGIONGN_00791	7.3e-19	comZ	-	-	S	ko:K02254	-	ko00000,ko02044	Competence protein ComG
BIGIONGN_00792	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIGIONGN_00793	3.32e-202	-	5.1.3.2	-	GM	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
BIGIONGN_00794	5.38e-154	yjaU	-	-	I	-	-	-	carboxylic ester hydrolase activity
BIGIONGN_00795	8.91e-220	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIGIONGN_00796	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
BIGIONGN_00797	2.17e-266	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
BIGIONGN_00798	4.3e-276	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
BIGIONGN_00799	8.28e-176	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIGIONGN_00800	3.1e-288	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIGIONGN_00801	3.4e-255	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIGIONGN_00802	1.08e-210	ctaG	-	-	S	ko:K02862	-	ko00000	cytochrome c oxidase
BIGIONGN_00803	1.57e-195	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
BIGIONGN_00804	2.72e-102	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_00805	1.78e-140	-	-	-	-	-	-	-	-
BIGIONGN_00806	3.4e-295	ywqB	-	-	S	-	-	-	zinc ion binding
BIGIONGN_00807	0.0	ywqA	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
BIGIONGN_00809	6.44e-18	-	-	-	S	-	-	-	Intracellular proteinase inhibitor
BIGIONGN_00810	7.65e-188	yitT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
BIGIONGN_00811	9.1e-191	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
BIGIONGN_00812	1.01e-56	-	-	-	-	-	-	-	-
BIGIONGN_00813	2.36e-84	ytwF	-	-	P	-	-	-	Sulfurtransferase
BIGIONGN_00814	2.04e-118	-	-	-	-	-	-	-	-
BIGIONGN_00815	0.0	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
BIGIONGN_00816	6.94e-200	ykgA	-	-	E	-	-	-	Amidinotransferase
BIGIONGN_00817	1.53e-62	-	-	-	S	-	-	-	IDEAL
BIGIONGN_00818	0.0	asnH	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
BIGIONGN_00819	7.11e-96	cheW	-	-	NT	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	chemotaxis
BIGIONGN_00820	0.0	cheA	2.7.13.3	-	NT	ko:K03407	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	COG0643 Chemotaxis protein histidine kinase and related kinases
BIGIONGN_00821	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
BIGIONGN_00822	0.0	addB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	exonuclease activity
BIGIONGN_00823	4.58e-82	-	-	-	-	-	-	-	-
BIGIONGN_00824	6.09e-144	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
BIGIONGN_00825	1.5e-184	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
BIGIONGN_00826	3.69e-190	pstBA	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
BIGIONGN_00827	2.52e-205	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
BIGIONGN_00828	4.11e-203	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
BIGIONGN_00829	1.04e-214	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
BIGIONGN_00830	6.86e-108	-	-	-	S	-	-	-	DinB family
BIGIONGN_00831	0.0	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
BIGIONGN_00832	3.41e-170	-	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
BIGIONGN_00833	3.51e-274	-	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
BIGIONGN_00834	2.15e-152	ung2	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
BIGIONGN_00836	9.33e-274	-	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
BIGIONGN_00837	2.47e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	SpoVT / AbrB like domain
BIGIONGN_00838	1.58e-59	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
BIGIONGN_00839	5.37e-74	ysxB	-	-	J	ko:K07584	-	ko00000	ribosomal protein
BIGIONGN_00840	5.22e-65	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
BIGIONGN_00841	0.0	cafA	-	-	J	ko:K08301	-	ko00000,ko01000,ko03009,ko03019	ribonuclease, Rne Rng family
BIGIONGN_00842	7.19e-198	spoIVFB	-	-	S	ko:K06402	-	ko00000,ko01000,ko01002	Stage IV sporulation protein
BIGIONGN_00843	7.8e-169	spoIVFA	-	-	M	ko:K06401	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
BIGIONGN_00844	1.48e-218	yqkF	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
BIGIONGN_00845	2.86e-121	-	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
BIGIONGN_00846	2.17e-97	-	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	MoaC family
BIGIONGN_00847	4.46e-119	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
BIGIONGN_00848	6.84e-183	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
BIGIONGN_00849	3.82e-157	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
BIGIONGN_00850	1.48e-103	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	shape-determining protein
BIGIONGN_00851	1.02e-203	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
BIGIONGN_00852	4.89e-239	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein MreB
BIGIONGN_00853	2.48e-157	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
BIGIONGN_00854	4.42e-136	maf	-	-	D	ko:K06287	-	ko00000	septum formation protein Maf
BIGIONGN_00855	0.0	yuxL	3.4.19.1	-	EU	ko:K01303	-	ko00000,ko01000,ko01002	peptidase
BIGIONGN_00856	2.89e-252	-	-	-	-	ko:K06380	-	ko00000	-
BIGIONGN_00857	9.19e-155	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
BIGIONGN_00858	9.35e-311	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
BIGIONGN_00859	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
BIGIONGN_00860	2.36e-42	-	-	-	-	-	-	-	-
BIGIONGN_00861	1.58e-148	-	-	-	-	-	-	-	-
BIGIONGN_00862	3.09e-245	ysxE	-	-	S	-	-	-	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIGIONGN_00863	5.55e-211	-	-	-	-	-	-	-	-
BIGIONGN_00864	4.16e-243	spoVID	-	-	M	ko:K06417	-	ko00000	stage VI sporulation protein D
BIGIONGN_00865	2.13e-313	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
BIGIONGN_00866	4e-233	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the ALAD family
BIGIONGN_00867	1.44e-178	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
BIGIONGN_00868	2.26e-216	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
BIGIONGN_00869	6.33e-187	hemX	-	-	O	ko:K02497	-	ko00000	cytochrome C
BIGIONGN_00870	0.0	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BIGIONGN_00871	1.08e-139	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
BIGIONGN_00872	0.0	lon	3.4.21.53	-	O	ko:K01338	ko04112,map04112	ko00000,ko00001,ko01000,ko01002	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BIGIONGN_00873	0.0	lonB	3.4.21.53	-	LO	ko:K04076	-	ko00000,ko01000,ko01002	Belongs to the peptidase S16 family
BIGIONGN_00874	2.85e-303	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BIGIONGN_00875	3.98e-295	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
BIGIONGN_00876	1.09e-230	ysoA	-	-	O	-	-	-	COG0457 FOG TPR repeat
BIGIONGN_00877	2.02e-144	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIGIONGN_00878	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIGIONGN_00879	3.13e-252	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
BIGIONGN_00880	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIGIONGN_00881	2.5e-235	ilvC	1.1.1.86	-	EH	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIGIONGN_00882	3.04e-111	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
BIGIONGN_00883	0.0	ilvB	2.2.1.6	-	E	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
BIGIONGN_00884	0.0	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
BIGIONGN_00885	8.81e-98	-	-	-	-	-	-	-	-
BIGIONGN_00886	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
BIGIONGN_00887	0.0	cotA	1.16.3.3	-	Q	ko:K06324	-	ko00000,ko01000	multicopper oxidases
BIGIONGN_00890	6.48e-125	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
BIGIONGN_00891	4.93e-141	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIGIONGN_00892	5.64e-175	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BIGIONGN_00893	4.75e-249	gerM	-	-	S	ko:K06298	-	ko00000	COG5401 Spore germination protein
BIGIONGN_00894	3.77e-250	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
BIGIONGN_00895	3.13e-42	-	-	-	C	-	-	-	4Fe-4S binding domain
BIGIONGN_00896	5.24e-193	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
BIGIONGN_00897	4e-105	ysmB	-	-	K	-	-	-	transcriptional
BIGIONGN_00898	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIGIONGN_00899	2.33e-52	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPr
BIGIONGN_00900	2.77e-45	gerE	-	-	K	ko:K01994	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_00901	9.16e-105	ysmA	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
BIGIONGN_00902	4.17e-186	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
BIGIONGN_00903	0.0	sdhA	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
BIGIONGN_00904	5.12e-145	sdhC	-	-	C	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	succinate dehydrogenase
BIGIONGN_00905	1.82e-295	ktrD	-	-	P	-	-	-	COG0168 Trk-type K transport systems, membrane components
BIGIONGN_00906	7.17e-99	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
BIGIONGN_00907	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
BIGIONGN_00908	1.37e-70	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
BIGIONGN_00909	1.26e-220	etfA	-	-	C	ko:K03522	-	ko00000,ko04147	Electron transfer flavoprotein
BIGIONGN_00910	4.25e-173	etfB	-	-	C	ko:K03521	-	ko00000	Electron transfer flavoprotein
BIGIONGN_00911	1.09e-175	fadB	4.2.1.17	-	I	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
BIGIONGN_00912	6.25e-134	fadR	-	-	K	ko:K13770	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_00913	0.0	lcfA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
BIGIONGN_00914	7.25e-88	yshE	-	-	S	ko:K08989	-	ko00000	membrane
BIGIONGN_00915	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
BIGIONGN_00916	0.0	polX	-	-	L	ko:K02347	-	ko00000,ko03400	COG1796 DNA polymerase IV (family X)
BIGIONGN_00917	5.01e-118	yshB	-	-	S	-	-	-	membrane protein, required for colicin V production
BIGIONGN_00918	6.35e-46	zapA	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIGIONGN_00919	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
BIGIONGN_00920	8.23e-247	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIGIONGN_00921	5.88e-175	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIGIONGN_00922	3.13e-42	sspI	-	-	S	ko:K06426	-	ko00000	Belongs to the SspI family
BIGIONGN_00924	1.45e-22	-	-	-	-	-	-	-	-
BIGIONGN_00925	1.84e-260	ysdC	-	-	G	-	-	-	COG1363 Cellulase M and related proteins
BIGIONGN_00926	7.91e-86	ysdB	-	-	S	-	-	-	Sigma-w pathway protein YsdB
BIGIONGN_00927	0.0	ywcA	-	-	S	ko:K14393	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIGIONGN_00928	9.32e-70	ywcB	-	-	S	-	-	-	Protein of unknown function, DUF485
BIGIONGN_00929	5.42e-75	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIGIONGN_00930	7.54e-40	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
BIGIONGN_00931	4.04e-111	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIGIONGN_00932	1.48e-269	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
BIGIONGN_00933	2.79e-153	yknY	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_00934	7.63e-305	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIGIONGN_00935	8.9e-168	-	-	-	-	-	-	-	-
BIGIONGN_00936	0.0	dacC	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
BIGIONGN_00937	2.3e-228	-	-	-	C	-	-	-	Aldo/keto reductase family
BIGIONGN_00938	8.16e-241	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_00939	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIGIONGN_00940	1.16e-208	ytxC	-	-	S	-	-	-	YtxC-like family
BIGIONGN_00941	2.85e-287	mqnC	1.21.98.1	-	H	ko:K11784	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
BIGIONGN_00942	1.48e-220	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
BIGIONGN_00943	0.0	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
BIGIONGN_00944	1.52e-103	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIGIONGN_00945	6.77e-87	-	-	-	-	-	-	-	-
BIGIONGN_00946	2.59e-89	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BIGIONGN_00947	4.26e-249	gapB	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
BIGIONGN_00948	2.44e-136	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BIGIONGN_00949	3.68e-136	ytaF	-	-	P	-	-	-	Probably functions as a manganese efflux pump
BIGIONGN_00950	7.85e-204	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
BIGIONGN_00951	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIGIONGN_00952	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase
BIGIONGN_00953	1.14e-169	phoP	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_00954	1.16e-97	-	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	helix_turn_helix ASNC type
BIGIONGN_00955	7.32e-219	mdh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible oxidation of malate to oxaloacetate
BIGIONGN_00956	1.08e-306	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	isocitrate
BIGIONGN_00957	1.53e-267	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
BIGIONGN_00958	4.98e-96	-	-	-	S	-	-	-	UPF0756 membrane protein
BIGIONGN_00959	6.55e-84	fxsA	-	-	S	ko:K07113	-	ko00000	COG3030 Protein affecting phage T7 exclusion by the F plasmid
BIGIONGN_00960	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
BIGIONGN_00961	1.14e-229	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
BIGIONGN_00962	1.68e-229	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
BIGIONGN_00963	9.45e-198	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIGIONGN_00964	1.01e-149	lutR_1	-	-	K	ko:K05799	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
BIGIONGN_00965	1.04e-287	ytsJ	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
BIGIONGN_00966	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
BIGIONGN_00967	4.62e-70	ytrH	-	-	S	-	-	-	Sporulation protein YtrH
BIGIONGN_00968	1.03e-117	ytrI	-	-	-	-	-	-	-
BIGIONGN_00969	7.67e-223	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	COG0618 Exopolyphosphatase-related proteins
BIGIONGN_00970	3.35e-11	ytpI	-	-	S	-	-	-	YtpI-like protein
BIGIONGN_00971	2.37e-308	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
BIGIONGN_00973	1.45e-166	ytkL	-	-	S	-	-	-	Belongs to the UPF0173 family
BIGIONGN_00974	3.91e-269	ykvY	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
BIGIONGN_00975	1.35e-85	-	-	-	-	-	-	-	-
BIGIONGN_00976	8.7e-179	ytkK	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_00978	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
BIGIONGN_00979	8.67e-297	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
BIGIONGN_00981	5.8e-219	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	3'-5' exoribonuclease yhaM
BIGIONGN_00982	1.23e-276	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIGIONGN_00983	1.19e-231	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
BIGIONGN_00984	3.35e-111	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIGIONGN_00985	8.63e-258	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_00986	1.19e-97	ytfJ	-	-	S	-	-	-	Sporulation protein YtfJ
BIGIONGN_00987	5.89e-161	ytfI	-	-	S	-	-	-	Protein of unknown function (DUF2953)
BIGIONGN_00988	1.14e-129	yteJ	-	-	S	-	-	-	RDD family
BIGIONGN_00989	2.4e-231	sppA	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	signal peptide peptidase SppA
BIGIONGN_00990	1.17e-38	-	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
BIGIONGN_00991	2.36e-288	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIGIONGN_00992	7.02e-268	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
BIGIONGN_00993	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIGIONGN_00994	8.97e-191	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	COG1387 Histidinol phosphatase and related hydrolases of the PHP family
BIGIONGN_00995	3.71e-147	yttP	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_00996	2.2e-115	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
BIGIONGN_00997	8.51e-143	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIGIONGN_00998	2.24e-300	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIGIONGN_00999	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
BIGIONGN_01000	0.0	acsA	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
BIGIONGN_01001	1.41e-155	acuA	-	-	K	ko:K04766	-	ko00000,ko01000	Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
BIGIONGN_01002	4.31e-149	acuB	-	-	S	ko:K04767	-	ko00000	Acetoin utilization protein AcuB
BIGIONGN_01003	5.67e-303	acuC	-	-	BQ	ko:K04768	-	ko00000	histone deacetylase
BIGIONGN_01004	1.24e-237	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
BIGIONGN_01005	1.18e-251	aroA	2.5.1.54, 5.4.99.5	-	E	ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
BIGIONGN_01006	3.48e-29	ytxH	-	-	S	-	-	-	COG4980 Gas vesicle protein
BIGIONGN_01007	1.68e-84	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIGIONGN_01008	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
BIGIONGN_01009	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
BIGIONGN_01010	1.64e-136	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
BIGIONGN_01011	2.92e-189	ytpQ	-	-	S	-	-	-	Belongs to the UPF0354 family
BIGIONGN_01012	6.89e-75	ytpP	-	-	CO	-	-	-	Thioredoxin
BIGIONGN_01013	4.08e-188	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
BIGIONGN_01014	5.77e-102	ytoQ	-	-	S	-	-	-	Nucleoside 2-deoxyribosyltransferase YtoQ
BIGIONGN_01015	1.86e-116	yjjX	-	-	F	-	-	-	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BIGIONGN_01016	5.5e-263	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
BIGIONGN_01017	2.23e-65	ytzB	-	-	-	-	-	-	-
BIGIONGN_01018	2.16e-156	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
BIGIONGN_01020	1.35e-198	ytmP	-	-	M	-	-	-	Phosphotransferase
BIGIONGN_01021	4.39e-211	purU	3.5.1.10	-	F	ko:K01433	ko00630,ko00670,map00630,map00670	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
BIGIONGN_01022	8.62e-166	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_01023	4.58e-69	-	-	-	S	-	-	-	PFAM Uncharacterised protein family UPF0150
BIGIONGN_01024	1.3e-281	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
BIGIONGN_01025	6.28e-248	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
BIGIONGN_01026	9.76e-229	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
BIGIONGN_01027	4.04e-279	lpdA	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGIONGN_01028	0.0	acoR	-	-	KQ	ko:K21405	-	ko00000,ko03000	COG3284 Transcriptional activator of acetoin glycerol metabolism
BIGIONGN_01029	4.53e-148	cidB	-	-	M	-	-	-	effector of murein hydrolase
BIGIONGN_01030	1.41e-84	-	-	-	S	ko:K06518	-	ko00000,ko02000	Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
BIGIONGN_01031	2.3e-140	ytlP	3.1.4.58	-	J	ko:K01975	-	ko00000,ko01000,ko03016	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BIGIONGN_01032	4.6e-220	ytkP	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
BIGIONGN_01033	2.36e-213	ydeE	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
BIGIONGN_01034	3.06e-64	adhR	-	-	K	ko:K21745	-	ko00000,ko03000	helix_turn_helix, mercury resistance
BIGIONGN_01035	1.63e-195	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_01036	8.58e-103	fosB	-	-	H	ko:K11210,ko:K21252	-	ko00000,ko01000,ko01504	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
BIGIONGN_01037	4.69e-43	ytzE	-	-	K	-	-	-	COG1349 Transcriptional regulators of sugar metabolism
BIGIONGN_01038	1.28e-172	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
BIGIONGN_01039	1.8e-269	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
BIGIONGN_01040	3.03e-258	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
BIGIONGN_01041	0.0	ytgP	-	-	S	ko:K03328,ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
BIGIONGN_01042	7.05e-216	yvrE	-	-	G	ko:K14274	ko00040,map00040	ko00000,ko00001,ko01000	SMP-30/Gluconolaconase/LRE-like region
BIGIONGN_01043	3.75e-94	yugU	-	-	S	-	-	-	Uncharacterised protein family UPF0047
BIGIONGN_01044	1.12e-291	yhaA1	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
BIGIONGN_01045	6.12e-265	ytfP	-	-	S	ko:K07007	-	ko00000	HI0933-like protein
BIGIONGN_01046	5.51e-85	-	-	-	-	-	-	-	-
BIGIONGN_01047	9.19e-99	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
BIGIONGN_01048	2.33e-169	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
BIGIONGN_01049	1.08e-307	-	-	-	S	ko:K12941	-	ko00000,ko01002	amidohydrolase
BIGIONGN_01050	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
BIGIONGN_01051	1.34e-231	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
BIGIONGN_01052	4.58e-243	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
BIGIONGN_01053	6.03e-134	ytqB	-	-	J	-	-	-	Putative rRNA methylase
BIGIONGN_01054	8.11e-138	yvdA	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
BIGIONGN_01055	1.84e-194	ytpA	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
BIGIONGN_01056	4.29e-99	ytoA	-	-	S	-	-	-	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIGIONGN_01057	2.35e-286	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIGIONGN_01058	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BIGIONGN_01059	9.52e-197	ytmA	-	-	E	-	-	-	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
BIGIONGN_01060	7.17e-233	ytlA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
BIGIONGN_01061	1.14e-175	ytlC	3.6.3.36	-	P	ko:K02049,ko:K10831,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGIONGN_01062	3.97e-41	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
BIGIONGN_01063	2.12e-125	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
BIGIONGN_01064	5.41e-115	ytkD	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
BIGIONGN_01065	1.65e-286	ymfD	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_01066	5.16e-110	ywpF	-	-	S	-	-	-	YwpF-like protein
BIGIONGN_01068	7.78e-284	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
BIGIONGN_01069	6.97e-150	dgk	2.7.1.113	-	F	ko:K15518	ko00230,map00230	ko00000,ko00001,ko01000	Deoxyguanosine kinase
BIGIONGN_01070	1.52e-154	dck	2.7.1.74, 2.7.1.76	-	F	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko01000	Deoxycytidine kinase
BIGIONGN_01071	9.52e-141	-	-	-	V	ko:K07448	-	ko00000,ko02048	Restriction endonuclease
BIGIONGN_01072	1.01e-225	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4607 ABC-type enterochelin transport system, periplasmic component
BIGIONGN_01073	8.38e-193	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_01074	1.1e-198	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_01075	1.23e-207	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_01076	2.92e-138	pgpB3	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	COG0671 Membrane-associated phospholipid phosphatase
BIGIONGN_01077	1.85e-302	tcyP	-	-	U	ko:K06956	-	ko00000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
BIGIONGN_01078	4.63e-101	-	-	-	S	-	-	-	Putative small multi-drug export protein
BIGIONGN_01079	2.95e-106	-	-	-	S	-	-	-	DinB superfamily
BIGIONGN_01080	9.46e-77	-	-	-	S	-	-	-	Protein of unknown function (DUF1516)
BIGIONGN_01081	4.94e-109	yneJ	-	-	O	-	-	-	COG4846 Membrane protein involved in cytochrome C biogenesis
BIGIONGN_01082	9.87e-211	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
BIGIONGN_01083	1.31e-215	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
BIGIONGN_01086	2.25e-29	-	-	-	-	-	-	-	-
BIGIONGN_01087	1.77e-93	yugN	-	-	S	-	-	-	YugN-like family
BIGIONGN_01088	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
BIGIONGN_01089	1.58e-263	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
BIGIONGN_01090	2.44e-288	yugJ	-	-	C	ko:K19955	-	ko00000,ko01000	oxidoreductases, Fe-dependent alcohol dehydrogenase family
BIGIONGN_01091	2.41e-45	yuzA	-	-	S	ko:K09779	-	ko00000	Domain of unknown function (DUF378)
BIGIONGN_01092	7.86e-77	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
BIGIONGN_01093	1.99e-262	yfmL	-	-	L	-	-	-	COG0513 Superfamily II DNA and RNA helicases
BIGIONGN_01094	6.3e-177	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIGIONGN_01095	3.31e-283	yugH	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Aminotransferase
BIGIONGN_01096	7.3e-111	alaR	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01097	4.49e-112	luxS	4.4.1.21	-	T	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
BIGIONGN_01098	6.56e-187	-	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
BIGIONGN_01099	1.81e-55	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
BIGIONGN_01100	1.56e-296	yuiF	-	-	S	ko:K07084	-	ko00000,ko02000	antiporter
BIGIONGN_01101	5.93e-60	-	-	-	-	-	-	-	-
BIGIONGN_01102	0.0	pepA	3.4.11.1	-	E	ko:K01255	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIGIONGN_01103	2.38e-103	yuiD	-	-	S	ko:K09775	-	ko00000	protein conserved in bacteria
BIGIONGN_01104	1.2e-145	yuiC	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01105	2.23e-62	yuiB	-	-	S	-	-	-	Putative membrane protein
BIGIONGN_01106	1.09e-293	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
BIGIONGN_01107	3.18e-237	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	reductase
BIGIONGN_01108	3.34e-266	mtlD	1.1.1.17	-	G	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	COG0246 Mannitol-1-phosphate altronate dehydrogenases
BIGIONGN_01109	4.11e-95	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
BIGIONGN_01110	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	transcriptional regulator, MtlR
BIGIONGN_01111	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
BIGIONGN_01112	1.91e-197	-	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
BIGIONGN_01113	4.06e-140	yckA	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
BIGIONGN_01114	2.5e-79	yutM	-	-	S	ko:K13628	-	ko00000,ko03016	Belongs to the HesB IscA family
BIGIONGN_01115	3.32e-13	-	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
BIGIONGN_01116	5.12e-267	mqnE	2.5.1.120	-	H	ko:K18285	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BIGIONGN_01117	5.77e-209	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIGIONGN_01118	9.92e-57	-	-	-	-	-	-	-	-
BIGIONGN_01119	3.63e-54	yuzB	-	-	S	-	-	-	Belongs to the UPF0349 family
BIGIONGN_01120	0.0	yutJ	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
BIGIONGN_01121	6.51e-69	yuzD	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01122	4.25e-49	yutI	-	-	O	-	-	-	COG0694 Thioredoxin-like proteins and domains
BIGIONGN_01123	3.07e-207	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
BIGIONGN_01124	2.38e-252	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIGIONGN_01125	4.19e-304	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
BIGIONGN_01126	2.16e-268	yutH	-	-	S	-	-	-	Spore coat protein
BIGIONGN_01127	1.37e-109	yutG	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
BIGIONGN_01128	4.63e-174	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
BIGIONGN_01129	1.65e-102	yutE	-	-	S	-	-	-	Protein of unknown function DUF86
BIGIONGN_01130	1.79e-59	-	-	-	-	-	-	-	-
BIGIONGN_01131	6.09e-67	yutD	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01132	3.39e-121	yutC	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
BIGIONGN_01133	3.64e-221	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BIGIONGN_01134	6.5e-261	lytH	-	-	M	ko:K21472	-	ko00000,ko01000,ko01002,ko01011	Peptidase, M23
BIGIONGN_01135	0.0	-	-	-	C	ko:K18218	-	ko00000,ko00002,ko01504,ko02000	Na+/H+ antiporter family
BIGIONGN_01136	3.14e-179	yunB	-	-	S	-	-	-	Sporulation protein YunB (Spo_YunB)
BIGIONGN_01137	1.61e-117	dfrA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIGIONGN_01138	2.96e-202	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIGIONGN_01139	6.82e-66	yunC	-	-	S	-	-	-	Domain of unknown function (DUF1805)
BIGIONGN_01140	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
BIGIONGN_01141	8.56e-181	yunE	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
BIGIONGN_01142	1.48e-216	yunF	-	-	S	-	-	-	Protein of unknown function DUF72
BIGIONGN_01143	1.7e-84	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
BIGIONGN_01144	7.07e-67	-	-	-	-	-	-	-	-
BIGIONGN_01145	6.44e-201	-	-	-	-	-	-	-	-
BIGIONGN_01147	1.12e-57	-	-	-	-	-	-	-	-
BIGIONGN_01148	1.04e-56	-	-	-	-	-	-	-	-
BIGIONGN_01150	4.69e-50	-	-	-	-	-	-	-	-
BIGIONGN_01151	3.3e-50	-	-	-	-	-	-	-	-
BIGIONGN_01152	2.72e-198	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_01153	1.85e-58	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
BIGIONGN_01154	3.62e-213	-	-	-	S	-	-	-	Phosphotransferase enzyme family
BIGIONGN_01155	1.54e-222	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
BIGIONGN_01156	3.19e-174	msmR	-	-	K	-	-	-	AraC family transcriptional regulator
BIGIONGN_01157	4.18e-237	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
BIGIONGN_01158	1.91e-179	-	-	-	Q	-	-	-	Methyltransferase domain
BIGIONGN_01159	2.14e-65	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
BIGIONGN_01161	1.83e-24	-	-	-	S	-	-	-	YhfH-like protein
BIGIONGN_01162	5.75e-303	aceA	4.1.3.1	-	C	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Isocitrate lyase
BIGIONGN_01163	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	FeS cluster assembly
BIGIONGN_01164	2.18e-101	nifU	-	-	C	ko:K04488	-	ko00000	COG0822 NifU homolog involved in Fe-S cluster formation
BIGIONGN_01165	3.17e-301	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIGIONGN_01166	2.3e-311	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
BIGIONGN_01167	8.04e-186	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
BIGIONGN_01168	7.34e-83	yurZ	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIGIONGN_01169	4.75e-216	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
BIGIONGN_01170	5.64e-125	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
BIGIONGN_01171	7.2e-200	metQ	-	-	P	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
BIGIONGN_01172	8.98e-149	metI	-	-	P	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
BIGIONGN_01173	8.09e-237	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGIONGN_01174	6.74e-84	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
BIGIONGN_01175	1.43e-84	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
BIGIONGN_01176	0.0	fadE	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
BIGIONGN_01177	8.7e-274	fadA	2.3.1.16	-	I	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the thiolase family
BIGIONGN_01178	0.0	fadN	1.1.1.35	-	I	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	ko00000,ko00001,ko00002,ko01000	3-hydroxyacyl-CoA dehydrogenase
BIGIONGN_01179	2.87e-288	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGIONGN_01180	0.0	-	-	-	S	-	-	-	Sugar transport-related sRNA regulator N-term
BIGIONGN_01181	6.17e-165	-	-	-	S	-	-	-	Glycosyltransferase like family
BIGIONGN_01182	3.63e-184	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
BIGIONGN_01183	6.97e-09	-	-	-	-	-	-	-	-
BIGIONGN_01184	7.81e-141	lip	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIGIONGN_01185	3.9e-316	gabT	2.6.1.19	-	E	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIGIONGN_01186	0.0	-	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01187	1.47e-19	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGIONGN_01189	1.12e-104	smpB	-	-	O	ko:K03664	-	ko00000	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BIGIONGN_01190	2.11e-80	-	-	-	S	ko:K15977	-	ko00000	DoxX
BIGIONGN_01191	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
BIGIONGN_01192	7.45e-179	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Carboxylesterase
BIGIONGN_01193	4.6e-177	-	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	COG1647 Esterase lipase
BIGIONGN_01194	1.64e-236	yceB	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIGIONGN_01195	9.6e-38	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
BIGIONGN_01196	9.92e-104	yclD	-	-	-	-	-	-	-
BIGIONGN_01197	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
BIGIONGN_01198	2.39e-103	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
BIGIONGN_01199	2.87e-221	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
BIGIONGN_01200	8.5e-286	-	4.2.1.158	-	M	ko:K20022	-	ko00000,ko01000	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
BIGIONGN_01201	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_01202	1.49e-223	-	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
BIGIONGN_01203	3.78e-156	-	-	-	K	-	-	-	FCD
BIGIONGN_01204	9.59e-305	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
BIGIONGN_01205	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of 2-phosphoglycerate and
BIGIONGN_01206	1.75e-171	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
BIGIONGN_01207	2.4e-278	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
BIGIONGN_01208	1.46e-240	gapA	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
BIGIONGN_01209	1.05e-230	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
BIGIONGN_01210	6.69e-263	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_01212	1.55e-55	XAC3035	-	-	O	ko:K06191	-	ko00000	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BIGIONGN_01213	7.37e-308	sigL	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
BIGIONGN_01214	4.06e-134	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
BIGIONGN_01215	2.39e-294	-	-	-	E	-	-	-	Peptidase dimerisation domain
BIGIONGN_01216	7.15e-75	-	-	-	S	ko:K09940	-	ko00000	Domain of unknown function (DUF4870)
BIGIONGN_01217	2.22e-277	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
BIGIONGN_01218	5.2e-139	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
BIGIONGN_01219	1.8e-220	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
BIGIONGN_01220	2.76e-142	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
BIGIONGN_01221	4.07e-52	crh	-	-	G	ko:K11184	-	ko00000	Phosphocarrier protein Chr
BIGIONGN_01222	2.16e-228	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
BIGIONGN_01223	1.09e-227	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
BIGIONGN_01224	4.57e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
BIGIONGN_01225	1.28e-117	yvcI	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	Nudix hydrolase
BIGIONGN_01226	2.04e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
BIGIONGN_01227	2.39e-253	yvcD	-	-	S	-	-	-	COG0457 FOG TPR repeat
BIGIONGN_01228	5.17e-312	cypC	1.11.2.4	-	Q	ko:K15629	-	ko00000,ko00199,ko01000	Cytochrome P450
BIGIONGN_01229	1.07e-188	-	-	-	K	-	-	-	FR47-like protein
BIGIONGN_01230	5.1e-147	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the PRA-CH family
BIGIONGN_01231	6.86e-177	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
BIGIONGN_01232	8.99e-167	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIGIONGN_01233	1.71e-150	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIGIONGN_01234	4.58e-140	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
BIGIONGN_01235	7.19e-298	hisD	1.1.1.23, 1.1.1.308	-	E	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIGIONGN_01236	3.55e-146	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
BIGIONGN_01237	1.15e-280	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIGIONGN_01238	2.68e-110	yvoF	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
BIGIONGN_01239	1.4e-152	ppaX	3.6.1.1	-	S	ko:K06019	ko00190,map00190	ko00000,ko00001,ko01000	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
BIGIONGN_01240	1.44e-206	yvoD	-	-	P	-	-	-	COG0370 Fe2 transport system protein B
BIGIONGN_01241	2.24e-199	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIGIONGN_01242	3.78e-219	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIGIONGN_01243	3.6e-64	yvlD	-	-	S	ko:K08972	-	ko00000	Membrane
BIGIONGN_01245	3.48e-205	yvlB	-	-	S	-	-	-	Putative adhesin
BIGIONGN_01246	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
BIGIONGN_01247	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
BIGIONGN_01248	1.66e-219	yoaV3	-	-	EG	-	-	-	EamA-like transporter family
BIGIONGN_01249	2.62e-264	minJ	-	-	O	-	-	-	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIGIONGN_01250	0.0	ctpB	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
BIGIONGN_01251	8.21e-175	-	-	-	D	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	peptidase
BIGIONGN_01252	7.66e-195	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
BIGIONGN_01253	7.42e-161	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
BIGIONGN_01254	8.63e-194	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
BIGIONGN_01255	1.24e-233	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIGIONGN_01256	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
BIGIONGN_01257	3.01e-126	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIGIONGN_01258	6.79e-42	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	cold-shock protein
BIGIONGN_01259	7.77e-198	-	-	-	-	-	-	-	-
BIGIONGN_01261	4.42e-87	fliS	-	-	N	ko:K02422	ko02040,map02040	ko00000,ko00001,ko02035	flagellar protein FliS
BIGIONGN_01262	0.0	fliD	-	-	N	ko:K02407	ko02040,map02040	ko00000,ko00001,ko02035	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BIGIONGN_01263	3.19e-66	flaG	-	-	N	ko:K06603	-	ko00000,ko02035	flagellar protein FlaG
BIGIONGN_01264	1.67e-46	csrA	-	-	T	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	ko00000,ko00001,ko03019	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIGIONGN_01265	2.99e-103	fliW	-	-	S	ko:K13626	-	ko00000,ko02035	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BIGIONGN_01266	4.08e-247	flgL	-	-	N	ko:K02397	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the bacterial flagellin family
BIGIONGN_01267	0.0	flgK	-	-	N	ko:K02396	ko02040,map02040	ko00000,ko00001,ko02035	flagellar hook-associated protein
BIGIONGN_01268	1.12e-07	yvyG	-	-	NOU	-	-	-	Flagellar biosynthesis protein FlgN
BIGIONGN_01269	6.14e-53	-	-	-	N	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	ko00000,ko00001,ko02035	Anti-sigma-28 factor, FlgM
BIGIONGN_01270	5.44e-99	yvyF	-	-	S	-	-	-	flagellar protein
BIGIONGN_01271	6.89e-168	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Phosphoribosyl transferase domain
BIGIONGN_01272	5.42e-240	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BIGIONGN_01273	3.16e-196	degV	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01274	4.63e-162	degU	-	-	KT	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
BIGIONGN_01275	6.87e-257	degS	2.7.13.3	-	T	ko:K07683,ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
BIGIONGN_01276	1.15e-150	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
BIGIONGN_01277	1.26e-139	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIGIONGN_01278	0.0	oppA1	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_01279	8.72e-203	oppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	binding-protein-dependent transport systems inner membrane component
BIGIONGN_01280	4.99e-225	oppB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_01281	5.46e-192	oppF	-	-	P	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_01282	2.28e-248	oppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_01283	2.96e-105	-	-	-	K	ko:K03718	-	ko00000,ko03000	helix_turn_helix ASNC type
BIGIONGN_01284	4.43e-251	ywtF_2	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01285	0.0	spoVB	-	-	S	ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
BIGIONGN_01286	2.15e-29	yrzD	-	-	S	-	-	-	Post-transcriptional regulator
BIGIONGN_01287	5.23e-295	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIGIONGN_01288	2.96e-196	secF	-	-	U	ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIGIONGN_01289	7.21e-53	yrvD	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
BIGIONGN_01290	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
BIGIONGN_01291	4.03e-120	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIGIONGN_01292	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIGIONGN_01293	1.32e-97	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
BIGIONGN_01294	4.02e-238	-	-	-	K	-	-	-	LacI family transcriptional regulator
BIGIONGN_01295	9.13e-185	thuA	-	-	G	-	-	-	Trehalose utilisation
BIGIONGN_01296	8.24e-248	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_01297	3.54e-281	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the UPF0214 family
BIGIONGN_01299	3.51e-310	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
BIGIONGN_01300	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIGIONGN_01301	2.16e-282	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
BIGIONGN_01302	5.89e-66	-	-	-	-	-	-	-	-
BIGIONGN_01303	1.05e-277	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
BIGIONGN_01304	3.52e-176	yrvM	-	-	H	ko:K22132	-	ko00000,ko03016	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
BIGIONGN_01305	3.15e-138	rsfA	-	-	S	ko:K06314	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_01306	4.87e-298	rarA	-	-	L	ko:K07478	-	ko00000	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
BIGIONGN_01307	2.93e-93	cymR	-	-	K	ko:K17472	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_01308	1.96e-273	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
BIGIONGN_01309	2.57e-276	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
BIGIONGN_01310	1.7e-65	yrrB	-	-	S	-	-	-	COG0457 FOG TPR repeat
BIGIONGN_01311	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
BIGIONGN_01312	4.85e-107	yrrD	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01313	1.11e-41	yrzR	-	-	-	-	-	-	-
BIGIONGN_01314	4.34e-240	yrrI	-	-	S	-	-	-	AI-2E family transporter
BIGIONGN_01315	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIGIONGN_01316	6.53e-58	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
BIGIONGN_01317	2.3e-96	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIGIONGN_01318	1.23e-44	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
BIGIONGN_01319	1.21e-268	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIGIONGN_01320	1.19e-150	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-methyltransferase
BIGIONGN_01321	5.68e-148	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
BIGIONGN_01322	8.99e-104	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
BIGIONGN_01323	3.68e-15	yrrS	-	-	S	-	-	-	Protein of unknown function (DUF1510)
BIGIONGN_01324	0.0	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
BIGIONGN_01325	4.13e-191	ku	-	-	L	ko:K10979	ko03450,map03450	ko00000,ko00001,ko03400	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BIGIONGN_01326	8.69e-161	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIGIONGN_01328	7.57e-103	-	-	-	-	-	-	-	-
BIGIONGN_01329	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
BIGIONGN_01330	7.14e-191	-	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGIONGN_01331	4.46e-185	-	-	-	P	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
BIGIONGN_01332	3.86e-206	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
BIGIONGN_01333	2.1e-197	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_01334	7.24e-141	arpR	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_01335	0.0	-	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Starch/carbohydrate-binding module (family 53)
BIGIONGN_01336	6.21e-147	XK27_06885	-	-	L	-	-	-	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
BIGIONGN_01337	3.46e-241	lplJ	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
BIGIONGN_01338	0.0	-	-	-	S	-	-	-	Membrane
BIGIONGN_01339	2.43e-285	hipO3	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
BIGIONGN_01340	5.3e-215	ybaS	-	-	S	-	-	-	Na -dependent transporter
BIGIONGN_01341	1.27e-159	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_01342	2.71e-35	-	-	-	-	-	-	-	-
BIGIONGN_01344	1.15e-70	-	-	-	-	-	-	-	-
BIGIONGN_01345	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
BIGIONGN_01346	0.0	nasD	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIGIONGN_01347	1.84e-74	nirD	1.7.1.15	-	P	ko:K00363	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite reductase
BIGIONGN_01348	0.0	nirB	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIGIONGN_01349	0.0	nasC	-	-	C	ko:K00372	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIGIONGN_01350	7.82e-283	nasA	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
BIGIONGN_01351	0.0	-	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
BIGIONGN_01353	1.76e-195	thiD	2.5.1.3, 2.7.1.49, 2.7.4.7	-	H	ko:K00941,ko:K14153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
BIGIONGN_01354	5.78e-57	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
BIGIONGN_01355	1.19e-88	-	-	-	P	ko:K05571	-	ko00000,ko02000	Na+/H+ antiporter subunit
BIGIONGN_01356	4.41e-52	-	-	-	P	ko:K05570	-	ko00000,ko02000	Multiple resistance and pH regulation protein F (MrpF / PhaF)
BIGIONGN_01357	1.54e-106	mrpE	-	-	P	ko:K05569	-	ko00000,ko02000	Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_01358	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_01359	4.59e-66	mnhC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_01360	1.09e-95	mrpB	-	-	P	ko:K05566	-	ko00000,ko02000	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
BIGIONGN_01361	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
BIGIONGN_01363	1.52e-125	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
BIGIONGN_01364	2.78e-275	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
BIGIONGN_01365	1.51e-196	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIGIONGN_01366	2.17e-62	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein containing KH domain, possibly ribosomal protein
BIGIONGN_01367	7.06e-138	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIGIONGN_01368	8.56e-140	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
BIGIONGN_01369	5.25e-81	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
BIGIONGN_01370	5.98e-208	yitL	-	-	S	ko:K00243	-	ko00000	protein conserved in bacteria
BIGIONGN_01371	5.69e-182	-	-	-	S	-	-	-	Methyltransferase domain
BIGIONGN_01372	3.69e-193	comER	-	-	E	ko:K02239	-	ko00000,ko00002,ko02044	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIGIONGN_01373	1.51e-138	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
BIGIONGN_01374	8.89e-143	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
BIGIONGN_01375	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
BIGIONGN_01376	9.62e-09	-	-	-	S	-	-	-	YqzM-like protein
BIGIONGN_01377	2.59e-232	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
BIGIONGN_01378	1.15e-48	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
BIGIONGN_01379	1.25e-262	gpr	3.4.24.78	-	C	ko:K06012	-	ko00000,ko01000,ko01002	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BIGIONGN_01380	6.75e-268	spoIIP	-	-	M	ko:K06385	-	ko00000	stage II sporulation protein P
BIGIONGN_01381	8.8e-70	-	-	-	-	-	-	-	-
BIGIONGN_01382	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
BIGIONGN_01383	1.15e-282	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
BIGIONGN_01384	7.24e-240	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
BIGIONGN_01385	3.52e-113	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIGIONGN_01386	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
BIGIONGN_01387	2.02e-268	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
BIGIONGN_01388	1.49e-223	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Methylates ribosomal protein L11
BIGIONGN_01389	5.19e-170	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
BIGIONGN_01390	0.0	yqeV	2.8.4.5	-	J	ko:K18707	-	ko00000,ko01000,ko03016	ribosomal protein S12 methylthiotransferase
BIGIONGN_01391	1.14e-176	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
BIGIONGN_01392	2.51e-280	gltT	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
BIGIONGN_01393	2.11e-148	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BIGIONGN_01394	6.08e-225	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
BIGIONGN_01395	4.15e-206	yqeW	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
BIGIONGN_01396	1.03e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
BIGIONGN_01397	3.29e-94	yqeY	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
BIGIONGN_01398	1.48e-291	yqeZ	-	-	O	ko:K07403	-	ko00000	COG1030 Membrane-bound serine protease (ClpP class)
BIGIONGN_01399	1.79e-156	yqfA	-	-	S	-	-	-	UPF0365 protein
BIGIONGN_01400	3.42e-107	-	-	-	-	-	-	-	-
BIGIONGN_01401	1.73e-63	yqfC	-	-	S	-	-	-	sporulation protein YqfC
BIGIONGN_01402	1.71e-283	yqfD	-	-	S	ko:K06438	-	ko00000	Stage IV sporulation
BIGIONGN_01403	1.6e-221	phoH	-	-	T	ko:K06217	-	ko00000	Phosphate starvation-inducible protein PhoH
BIGIONGN_01404	0.0	yqfF	-	-	S	ko:K07037	-	ko00000	membrane-associated HD superfamily hydrolase
BIGIONGN_01405	1.68e-109	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIGIONGN_01406	4.46e-81	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
BIGIONGN_01407	2.32e-94	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
BIGIONGN_01408	1.22e-216	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIGIONGN_01409	5.12e-25	-	-	-	S	-	-	-	YqzL-like protein
BIGIONGN_01410	3.69e-183	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
BIGIONGN_01412	1.18e-219	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
BIGIONGN_01413	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
BIGIONGN_01414	1.28e-144	ccpN	-	-	K	-	-	-	CBS domain
BIGIONGN_01415	1.01e-183	yqfL	2.7.11.33, 2.7.4.28	-	S	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
BIGIONGN_01416	5.47e-103	yqxD	-	-	S	ko:K09768	-	ko00000	Belongs to the UPF0178 family
BIGIONGN_01417	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
BIGIONGN_01418	1.45e-257	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
BIGIONGN_01419	4.86e-84	cccA	-	-	C	ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
BIGIONGN_01420	1.49e-180	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
BIGIONGN_01421	5.88e-257	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIGIONGN_01422	9.03e-229	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIGIONGN_01423	1.65e-111	-	-	-	K	ko:K07736	-	ko00000,ko03000	Transcription factor
BIGIONGN_01424	9.84e-106	yqfQ	-	-	S	-	-	-	YqfQ-like protein
BIGIONGN_01425	0.0	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
BIGIONGN_01426	1.31e-210	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIGIONGN_01428	2.78e-274	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
BIGIONGN_01429	9.77e-170	-	-	-	M	-	-	-	Transglycosylase SLT domain
BIGIONGN_01430	2.06e-185	zurA	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
BIGIONGN_01431	9.87e-185	zurM	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
BIGIONGN_01432	3.86e-102	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
BIGIONGN_01433	1.79e-50	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1540)
BIGIONGN_01434	7.94e-145	yqfW	-	-	S	ko:K05967	-	ko00000	Belongs to the 5'(3')-deoxyribonucleotidase family
BIGIONGN_01435	1.19e-88	yqfX	-	-	S	-	-	-	membrane
BIGIONGN_01436	6.11e-256	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BIGIONGN_01437	2.73e-79	fimV	-	-	NU	ko:K08086,ko:K15845	ko05120,map05120	ko00000,ko00001	translation initiation factor activity
BIGIONGN_01438	1.06e-244	-	-	-	EGP	ko:K08221	-	ko00000,ko02000	Sugar (and other) transporter
BIGIONGN_01439	1.61e-196	ypuA	-	-	S	-	-	-	Secreted protein
BIGIONGN_01440	6.09e-152	-	-	-	O	-	-	-	NfeD-like C-terminal, partner-binding
BIGIONGN_01441	2.39e-253	XK27_00915	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIGIONGN_01442	0.0	yjbB	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
BIGIONGN_01448	1.93e-149	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
BIGIONGN_01449	7.48e-298	yqgE	-	-	EGP	ko:K08222	-	ko00000,ko02000	Major facilitator superfamily
BIGIONGN_01450	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
BIGIONGN_01451	4.99e-101	-	-	-	S	-	-	-	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIGIONGN_01452	2.23e-80	-	-	-	-	-	-	-	-
BIGIONGN_01453	3.15e-162	-	-	-	G	-	-	-	PFAM Glycoside hydrolase 15-related
BIGIONGN_01454	6.04e-27	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
BIGIONGN_01455	4.98e-131	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIGIONGN_01456	2.39e-184	-	-	-	S	-	-	-	Integral membrane protein DUF92
BIGIONGN_01457	4.38e-243	moeB	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
BIGIONGN_01458	1.33e-309	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
BIGIONGN_01460	0.0	gluP	3.4.21.105	-	O	ko:K19225	-	ko00000,ko01000,ko01002	membrane protein (homolog of Drosophila rhomboid)
BIGIONGN_01461	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Bacillus/Clostridium GerA spore germination protein
BIGIONGN_01462	8.61e-89	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
BIGIONGN_01463	6.67e-109	-	-	-	-	-	-	-	-
BIGIONGN_01464	8.32e-12	yqgQ	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01465	2.92e-231	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
BIGIONGN_01466	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Aspartate ammonia-lyase
BIGIONGN_01467	1.15e-140	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
BIGIONGN_01468	4.45e-38	-	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	ThiS family
BIGIONGN_01469	1.74e-180	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
BIGIONGN_01470	1.08e-270	thiO	1.4.3.19	-	E	ko:K03153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Glycine oxidase
BIGIONGN_01471	1.13e-185	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
BIGIONGN_01472	1.18e-128	-	-	-	-	-	-	-	-
BIGIONGN_01473	5.01e-251	yqgV	-	-	S	-	-	-	Thiamine-binding protein
BIGIONGN_01474	1.64e-103	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_01475	1.25e-123	yjcG	-	-	J	-	-	-	Belongs to the 2H phosphoesterase superfamily. YjcG family
BIGIONGN_01476	2.06e-178	yjcH	-	-	P	ko:K07214	-	ko00000	COG2382 Enterochelin esterase and related enzymes
BIGIONGN_01477	4.16e-42	-	-	-	-	-	-	-	-
BIGIONGN_01478	2.49e-67	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_01479	2.58e-41	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGIONGN_01480	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
BIGIONGN_01481	3.8e-105	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
BIGIONGN_01482	1.37e-120	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIGIONGN_01483	1.33e-229	-	-	-	F	-	-	-	GHKL domain
BIGIONGN_01484	1.92e-216	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
BIGIONGN_01485	6.58e-122	yqjB	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01487	3.72e-95	mce	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0346 Lactoylglutathione lyase and related lyases
BIGIONGN_01488	7.72e-256	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	COG2195 Di- and tripeptidases
BIGIONGN_01491	1e-91	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
BIGIONGN_01492	9.53e-107	-	-	-	S	-	-	-	Pfam Polyketide cyclase dehydrase and lipid transport
BIGIONGN_01493	7.08e-96	ykuL	-	-	S	-	-	-	CBS domain
BIGIONGN_01494	3.53e-56	-	-	-	-	-	-	-	-
BIGIONGN_01495	0.0	apr	-	-	O	-	-	-	Belongs to the peptidase S8 family
BIGIONGN_01496	8.08e-192	yibQ	-	-	S	ko:K09798	-	ko00000	protein conserved in bacteria
BIGIONGN_01497	3.57e-62	tnrA	-	-	K	-	-	-	transcriptional
BIGIONGN_01498	6.24e-66	-	-	-	-	-	-	-	-
BIGIONGN_01500	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
BIGIONGN_01501	2.33e-167	-	-	-	P	ko:K08714	-	ko00000,ko02000	Polycystin cation channel
BIGIONGN_01502	1.6e-186	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIGIONGN_01503	6.52e-289	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIGIONGN_01504	1.3e-264	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIGIONGN_01505	0.0	asnO	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
BIGIONGN_01506	1.71e-239	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
BIGIONGN_01507	3.54e-110	-	-	-	V	-	-	-	COG4767 Glycopeptide antibiotics resistance protein
BIGIONGN_01508	1.08e-71	ogt	-	-	L	ko:K07443	-	ko00000	Methyltransferase
BIGIONGN_01509	2.49e-128	yvbF	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
BIGIONGN_01510	2.45e-109	ypqE	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
BIGIONGN_01511	9.24e-122	-	-	-	S	-	-	-	UPF0316 protein
BIGIONGN_01512	1.73e-270	mtnW	5.3.2.5	-	G	ko:K08965	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
BIGIONGN_01513	2.65e-182	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
BIGIONGN_01514	8.65e-116	-	-	-	CO	-	-	-	Thioredoxin-like
BIGIONGN_01516	1.1e-121	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
BIGIONGN_01517	3.53e-142	spoIIM	-	-	S	ko:K06384	-	ko00000	Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
BIGIONGN_01518	2.66e-112	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
BIGIONGN_01519	8.77e-19	-	-	-	S	-	-	-	Protein of unknown function (DUF4227)
BIGIONGN_01520	1.87e-217	xerD	-	-	L	ko:K04763	-	ko00000,ko03036	recombinase XerD
BIGIONGN_01521	8.89e-290	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BIGIONGN_01522	4.21e-302	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	phosphorylase
BIGIONGN_01523	4.19e-92	ohrB	-	-	O	-	-	-	Organic hydroperoxide resistance protein
BIGIONGN_01524	3.72e-154	-	-	-	J	-	-	-	translation release factor activity
BIGIONGN_01525	9.25e-306	ycnB	-	-	EGP	-	-	-	the major facilitator superfamily
BIGIONGN_01526	4.52e-29	yycD	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
BIGIONGN_01527	4.46e-74	-	-	-	-	-	-	-	-
BIGIONGN_01528	3.83e-109	yvsG	-	-	S	ko:K07038	-	ko00000	LexA-binding, inner membrane-associated putative hydrolase
BIGIONGN_01529	3.24e-182	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
BIGIONGN_01530	2.05e-276	dacF	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
BIGIONGN_01531	7.27e-73	spoIIAA	-	-	T	ko:K06378	-	ko00000	Belongs to the anti-sigma-factor antagonist family
BIGIONGN_01532	1.32e-97	spoIIAB	2.7.11.1	-	F	ko:K06379	-	ko00000,ko01000	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
BIGIONGN_01533	9.34e-176	sigF	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_01534	7.14e-105	-	-	-	S	ko:K06405	-	ko00000	Pfam:SpoVA
BIGIONGN_01535	2.93e-235	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
BIGIONGN_01536	8.69e-76	-	-	-	S	ko:K06407	-	ko00000	Pfam:SpoVA
BIGIONGN_01537	5.35e-139	spoVAEA	-	-	S	ko:K06407	-	ko00000	Stage V sporulation protein AE
BIGIONGN_01538	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Stage V sporulation protein AF
BIGIONGN_01539	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
BIGIONGN_01540	4.61e-106	ppiB	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIGIONGN_01541	5.1e-207	ccpC	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01542	8.78e-262	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
BIGIONGN_01544	1.47e-266	mmgD	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
BIGIONGN_01545	0.0	prpD	4.2.1.79	-	S	ko:K01720	ko00640,map00640	ko00000,ko00001,ko01000	2-methylcitrate dehydratase
BIGIONGN_01546	1.16e-209	prpB	4.1.3.30, 5.4.2.9	-	G	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BIGIONGN_01547	1.25e-208	hgd	1.1.1.31, 1.1.1.60	-	I	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	ko00000,ko00001,ko01000	3-hydroxyisobutyrate dehydrogenase
BIGIONGN_01548	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_01549	1.05e-251	-	-	-	I	-	-	-	3-hydroxyisobutyryl-CoA hydrolase
BIGIONGN_01550	2.59e-144	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
BIGIONGN_01551	6.5e-289	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIGIONGN_01552	1.39e-106	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
BIGIONGN_01553	6.41e-111	ypuF	-	-	S	ko:K09763	-	ko00000	Domain of unknown function (DUF309)
BIGIONGN_01554	2.26e-161	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIGIONGN_01555	3.87e-126	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIGIONGN_01556	4.98e-137	-	-	-	K	-	-	-	Uncharacterized protein conserved in bacteria (DUF2087)
BIGIONGN_01557	0.0	acoD	-	-	C	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family
BIGIONGN_01558	9.28e-218	sodF	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Superoxide dismutase
BIGIONGN_01559	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIGIONGN_01560	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	ABC1 family
BIGIONGN_01561	9.37e-60	-	-	-	S	-	-	-	ATP synthase, subunit b
BIGIONGN_01562	1.56e-161	-	-	-	S	-	-	-	membrane
BIGIONGN_01563	5.4e-59	-	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
BIGIONGN_01564	5.44e-104	spoVAC	-	-	S	ko:K06405	-	ko00000	stage V sporulation protein AC
BIGIONGN_01565	5.15e-247	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
BIGIONGN_01566	1.46e-73	spoVAE	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
BIGIONGN_01567	5.42e-275	dacB	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
BIGIONGN_01568	8.76e-131	spmA	-	-	S	ko:K06373	-	ko00000	Spore maturation protein
BIGIONGN_01569	2.1e-104	spmB	-	-	S	ko:K06374	-	ko00000	Spore maturation protein
BIGIONGN_01570	3.81e-169	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
BIGIONGN_01571	5.06e-126	resA	-	-	CO	-	-	-	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
BIGIONGN_01572	0.0	resB	-	-	O	ko:K07399	-	ko00000	COG1333 ResB protein required for cytochrome c biosynthesis
BIGIONGN_01573	1.35e-282	resC	-	-	O	-	-	-	'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
BIGIONGN_01574	2.69e-167	resD	-	-	T	ko:K07775	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_01575	0.0	resE	2.7.13.3	-	T	ko:K07651	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_01577	2.85e-244	btuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_01578	3.67e-180	yvrA	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
BIGIONGN_01579	1.18e-127	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Adenosyltransferase
BIGIONGN_01581	5e-175	ykoY	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
BIGIONGN_01582	0.0	nox	1.11.1.1	-	P	ko:K05910	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGIONGN_01583	0.0	serA	1.1.1.399, 1.1.1.95	-	E	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGIONGN_01584	2.77e-58	fer	-	-	C	ko:K05337	-	ko00000	Ferredoxin
BIGIONGN_01585	1.11e-242	ypbB	5.1.3.1	-	S	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	protein conserved in bacteria
BIGIONGN_01586	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGIONGN_01587	3.63e-135	ypbD	-	-	S	ko:K07052	-	ko00000	metal-dependent membrane protease
BIGIONGN_01590	1.3e-69	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_01591	3.14e-52	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_01593	2.27e-289	-	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyl Transferase
BIGIONGN_01594	5e-253	-	-	GT4	M	ko:K13678	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGIONGN_01595	1.94e-229	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIGIONGN_01597	5.33e-287	-	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
BIGIONGN_01598	1.44e-187	ypbG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
BIGIONGN_01599	5.4e-222	ycgE	-	-	K	ko:K22491	-	ko00000,ko03000	MerR family transcriptional regulator
BIGIONGN_01600	8.17e-141	mecB	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
BIGIONGN_01601	2.41e-165	-	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_01602	0.0	-	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
BIGIONGN_01603	6.02e-246	-	-	-	-	-	-	-	-
BIGIONGN_01604	7.53e-304	gudB	1.4.1.2, 1.4.1.4	-	E	ko:K00260,ko:K00262	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
BIGIONGN_01605	2.47e-231	ypdA	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	COG0492 Thioredoxin reductase
BIGIONGN_01606	1.05e-230	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
BIGIONGN_01607	4.14e-146	prsW	-	-	S	-	-	-	Involved in the degradation of specific anti-sigma factors
BIGIONGN_01608	8.25e-36	-	-	-	-	-	-	-	-
BIGIONGN_01609	1.58e-263	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
BIGIONGN_01610	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
BIGIONGN_01611	0.0	metH	2.1.1.13	-	E	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
BIGIONGN_01612	4.76e-215	sleB	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Spore cortex-lytic enzyme
BIGIONGN_01613	0.0	ypeB	-	-	H	ko:K06313	-	ko00000	sporulation protein
BIGIONGN_01614	2.95e-170	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
BIGIONGN_01615	4.75e-138	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	1-acyl-sn-glycerol-3-phosphate acyltransferase
BIGIONGN_01616	5.04e-259	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
BIGIONGN_01618	1.89e-316	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
BIGIONGN_01619	3.54e-133	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
BIGIONGN_01620	1.7e-237	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
BIGIONGN_01621	5.25e-54	-	-	-	S	-	-	-	Stage VI sporulation protein F
BIGIONGN_01622	8.81e-10	yphE	-	-	S	-	-	-	Protein of unknown function (DUF2768)
BIGIONGN_01623	1.66e-174	yphF	-	-	-	-	-	-	-
BIGIONGN_01624	0.0	spoIVA	-	-	S	ko:K06398	-	ko00000	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIGIONGN_01625	4.09e-131	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
BIGIONGN_01626	1.85e-48	mtrB	-	-	K	ko:K06285	-	ko00000,ko03000	Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
BIGIONGN_01627	6.72e-73	hepS	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	heptaprenyl diphosphate synthase
BIGIONGN_01628	3.84e-170	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
BIGIONGN_01629	4.87e-203	ubiA	2.5.1.39	-	H	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
BIGIONGN_01630	1.72e-207	mqnA	4.2.1.151	-	S	ko:K11782	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BIGIONGN_01631	2.93e-234	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
BIGIONGN_01632	6.26e-101	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
BIGIONGN_01633	2.4e-186	cheR	2.1.1.80	-	NT	ko:K00575	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko01000,ko02035	COG1352 Methylase of chemotaxis methyl-accepting proteins
BIGIONGN_01634	3.58e-281	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIGIONGN_01635	1.18e-253	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIGIONGN_01636	6.53e-77	aroH	5.4.99.5	-	E	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
BIGIONGN_01637	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIGIONGN_01638	9.12e-238	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIGIONGN_01639	3.1e-170	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
BIGIONGN_01640	1.02e-147	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosylanthranilate isomerase activity
BIGIONGN_01641	1.04e-286	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BIGIONGN_01642	9.78e-190	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
BIGIONGN_01643	9.88e-263	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIGIONGN_01644	4.68e-259	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
BIGIONGN_01645	2.85e-302	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
BIGIONGN_01646	1.85e-301	ypiA	-	-	S	-	-	-	COG0457 FOG TPR repeat
BIGIONGN_01647	4.13e-127	ypiB	-	-	S	-	-	-	Belongs to the UPF0302 family
BIGIONGN_01648	3.85e-108	ypiF	-	-	S	-	-	-	Protein of unknown function (DUF2487)
BIGIONGN_01649	3.64e-119	qcrA	-	-	C	ko:K03886	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Menaquinol-cytochrome c reductase
BIGIONGN_01650	8.39e-159	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
BIGIONGN_01651	2.15e-192	qcrC	-	-	C	ko:K03888	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	Menaquinol-cytochrome c reductase cytochrome b c subunit
BIGIONGN_01652	1.8e-141	ypjA	-	-	S	-	-	-	membrane
BIGIONGN_01653	1.1e-180	-	-	-	S	-	-	-	Sporulation protein YpjB (SpoYpjB)
BIGIONGN_01654	1.21e-151	yugP	-	-	S	ko:K06973	-	ko00000	Zn-dependent protease
BIGIONGN_01655	9.3e-273	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
BIGIONGN_01656	3.86e-202	ypjC	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
BIGIONGN_01657	2.69e-79	ypjD	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
BIGIONGN_01658	1.23e-185	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
BIGIONGN_01659	4.83e-98	mgsA	4.2.3.3	-	G	ko:K01734	ko00640,ko01120,map00640,map01120	ko00000,ko00001,ko01000	methylglyoxal synthase
BIGIONGN_01660	1.12e-110	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_01661	6.15e-300	hint	6.5.1.3	-	S	ko:K14415	-	ko00000,ko01000,ko03016	tRNA-splicing ligase RtcB
BIGIONGN_01662	3.33e-51	-	-	-	-	-	-	-	-
BIGIONGN_01663	6.32e-99	yyaT	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_01664	3.29e-183	-	-	-	Q	-	-	-	Methyltransferase domain
BIGIONGN_01665	3.68e-69	-	-	-	-	-	-	-	-
BIGIONGN_01667	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIGIONGN_01668	3.05e-126	-	-	-	S	-	-	-	Protein of unknown function (DUF1706)
BIGIONGN_01669	0.0	gnd	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIGIONGN_01670	6.63e-173	yodH	-	-	Q	-	-	-	Methyltransferase
BIGIONGN_01671	3.24e-221	-	-	-	M	-	-	-	3D domain
BIGIONGN_01672	5.82e-232	-	-	-	M	-	-	-	3D domain
BIGIONGN_01673	4.7e-204	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIGIONGN_01674	7.25e-265	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
BIGIONGN_01675	1.64e-196	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
BIGIONGN_01676	7.48e-133	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
BIGIONGN_01677	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGIONGN_01678	1.62e-186	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
BIGIONGN_01679	4.57e-147	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
BIGIONGN_01680	7.37e-139	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
BIGIONGN_01681	1.28e-151	-	-	CBM50	M	ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
BIGIONGN_01682	8.06e-301	-	-	-	S	-	-	-	Acetyltransferase
BIGIONGN_01683	9.96e-135	yvdT	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01684	1.58e-238	yvbT	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIGIONGN_01685	9.74e-176	spoIISA	-	-	S	ko:K06388	-	ko00000	Toxin SpoIISA, type II toxin-antitoxin system
BIGIONGN_01686	1.35e-240	ywcH1	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIGIONGN_01687	3.77e-218	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Cysteine synthase
BIGIONGN_01688	3.92e-269	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
BIGIONGN_01689	2.97e-76	yetG	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
BIGIONGN_01690	0.0	asbA	-	-	Q	-	-	-	Siderophore biosynthesis protein
BIGIONGN_01691	0.0	asbB	-	-	Q	-	-	-	IucA / IucC family
BIGIONGN_01692	1.4e-302	asbC	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	AMP-binding enzyme C-terminal domain
BIGIONGN_01693	4.48e-55	asbD	-	-	IQ	-	-	-	Phosphopantetheine attachment site
BIGIONGN_01694	6.63e-243	asbE	-	-	IQ	-	-	-	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIGIONGN_01695	1.72e-207	asbF	4.2.1.118	-	G	ko:K15652	ko00400,ko01110,ko01130,map00400,map01110,map01130	ko00000,ko00001,ko01000	Xylose isomerase-like TIM barrel
BIGIONGN_01696	2.53e-127	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	D,D-heptose 1,7-bisphosphate phosphatase
BIGIONGN_01697	9.82e-315	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
BIGIONGN_01698	6.97e-199	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
BIGIONGN_01699	4.79e-161	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
BIGIONGN_01701	3.79e-193	ywfM	-	-	EG	ko:K03298	-	ko00000,ko02000	EamA-like transporter family
BIGIONGN_01703	1.18e-72	yitW	-	-	S	-	-	-	metal-sulfur cluster biosynthetic enzyme
BIGIONGN_01704	5.41e-08	-	-	-	S	-	-	-	Putative methionine and alanine importer, small subunit
BIGIONGN_01705	0.0	-	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
BIGIONGN_01706	3.5e-206	-	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
BIGIONGN_01707	4.21e-126	-	-	-	K	-	-	-	Virulence activator alpha C-term
BIGIONGN_01708	7.79e-112	-	-	-	S	-	-	-	Domain of unknown function (DUF4188)
BIGIONGN_01709	2.8e-277	blt	-	-	EGP	ko:K08153,ko:K19578	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_01710	6.15e-181	-	-	-	-	-	-	-	-
BIGIONGN_01711	3.16e-183	ant1	2.7.7.47	-	H	ko:K00984	-	ko00000,ko01000,ko01504	Mediates bacterial resistance to the antibiotics streptomycin and spectomycin
BIGIONGN_01712	1.46e-69	-	-	-	-	-	-	-	-
BIGIONGN_01713	6.14e-15	yxlE	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
BIGIONGN_01714	9.25e-217	yxlF	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_01715	9e-181	yxlG	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
BIGIONGN_01716	3.17e-124	sigY	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
BIGIONGN_01718	1.04e-39	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
BIGIONGN_01719	2.97e-226	-	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Alpha beta hydrolase
BIGIONGN_01720	2.93e-92	-	-	-	S	-	-	-	Bacterial PH domain
BIGIONGN_01721	2.88e-60	-	-	-	S	-	-	-	Belongs to the LOG family
BIGIONGN_01722	1.84e-116	-	-	-	C	-	-	-	HEAT repeats
BIGIONGN_01723	9.9e-163	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	This enzyme is an effector of chloramphenicol resistance in bacteria
BIGIONGN_01724	2.35e-138	ydeI	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
BIGIONGN_01725	1.01e-48	-	-	-	K	-	-	-	COG0202 DNA-directed RNA polymerase, alpha subunit 40 kD subunit
BIGIONGN_01726	7.87e-146	-	-	-	S	-	-	-	Golgi phosphoprotein 3 (GPP34)
BIGIONGN_01727	5.87e-194	yqfU	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
BIGIONGN_01728	2.56e-180	motA	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
BIGIONGN_01729	1.27e-172	motB	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
BIGIONGN_01730	1.97e-259	ytvI	-	-	S	-	-	-	sporulation integral membrane protein YtvI
BIGIONGN_01731	2.49e-111	yocK	-	-	T	-	-	-	general stress protein
BIGIONGN_01732	6.66e-79	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2200)
BIGIONGN_01733	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
BIGIONGN_01734	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
BIGIONGN_01735	1.79e-92	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
BIGIONGN_01736	0.0	proWX	-	-	EM	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
BIGIONGN_01737	1.59e-244	opuBA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
BIGIONGN_01738	2.92e-188	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_01739	8.78e-130	-	-	-	U	-	-	-	MarC family integral membrane protein
BIGIONGN_01740	0.0	ypwA	3.4.17.19	-	E	ko:K01299	-	ko00000,ko01000,ko01002	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BIGIONGN_01741	1.96e-69	-	-	-	S	-	-	-	Belongs to the HesB IscA family
BIGIONGN_01742	1.6e-122	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
BIGIONGN_01743	1.44e-277	-	-	-	G	-	-	-	Transmembrane secretion effector
BIGIONGN_01745	1.75e-28	-	-	-	S	-	-	-	Protein of unknown function (DUF2564)
BIGIONGN_01746	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
BIGIONGN_01747	3.09e-66	-	-	-	-	-	-	-	-
BIGIONGN_01748	6.31e-79	-	-	-	S	-	-	-	Src homology 3 domains
BIGIONGN_01749	0.0	-	-	-	P	-	-	-	Spore gernimation protein GerA
BIGIONGN_01750	6.28e-251	-	-	-	E	-	-	-	Spore germination protein
BIGIONGN_01751	5.42e-254	-	-	-	S	ko:K06308	-	ko00000	Spore germination B3/ GerAC like, C-terminal
BIGIONGN_01753	3.68e-223	-	-	-	NT	-	-	-	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
BIGIONGN_01754	6.96e-83	-	-	-	-	-	-	-	-
BIGIONGN_01755	1.04e-83	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
BIGIONGN_01756	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
BIGIONGN_01757	1.77e-237	-	-	-	S	-	-	-	Oxidoreductase
BIGIONGN_01758	1.63e-282	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
BIGIONGN_01759	4.7e-52	-	-	-	-	-	-	-	-
BIGIONGN_01760	5.36e-271	-	-	-	L	ko:K07496	-	ko00000	Transposase
BIGIONGN_01761	8.9e-92	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
BIGIONGN_01762	2.65e-64	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
BIGIONGN_01763	3.49e-127	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
BIGIONGN_01764	3.2e-07	cotD	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
BIGIONGN_01765	8.95e-293	yprB	-	-	L	ko:K07502	-	ko00000	RNase_H superfamily
BIGIONGN_01766	0.0	yprA	-	-	L	ko:K06877	-	ko00000	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
BIGIONGN_01767	0.0	pepF	-	-	E	-	-	-	oligoendopeptidase F
BIGIONGN_01768	0.0	gerAA	-	-	EG	ko:K06288,ko:K06310	-	ko00000	Spore germination protein
BIGIONGN_01769	1.07e-242	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
BIGIONGN_01770	7.2e-236	pucA	1.17.1.4	-	O	ko:K00087,ko:K07402	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BIGIONGN_01771	9.89e-239	-	-	-	P	-	-	-	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
BIGIONGN_01772	1.08e-186	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_01773	3.12e-179	-	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
BIGIONGN_01774	1.89e-240	-	-	-	P	-	-	-	NMT1-like family
BIGIONGN_01775	1.49e-194	-	-	-	P	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_01776	9.74e-178	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
BIGIONGN_01777	0.0	fhuB5	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_01778	1.76e-234	cbrA5	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Ferrichrome ABC transporter substrate-binding protein
BIGIONGN_01779	4.57e-90	-	-	-	FG	ko:K02503	-	ko00000,ko04147	Scavenger mRNA decapping enzyme C-term binding
BIGIONGN_01780	9.11e-106	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
BIGIONGN_01781	1.2e-105	-	-	-	S	-	-	-	ASCH
BIGIONGN_01782	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 2 family
BIGIONGN_01783	1.44e-197	-	-	-	I	-	-	-	Domain of unknown function (DUF1932)
BIGIONGN_01784	1.7e-199	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGIONGN_01785	4.34e-151	-	4.1.3.17	-	H	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	ko00000,ko00001,ko01000	Methyltransferase
BIGIONGN_01786	2.72e-42	-	-	-	-	-	-	-	-
BIGIONGN_01787	2.03e-307	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
BIGIONGN_01788	1.37e-160	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_01789	1.15e-232	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01790	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_01791	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
BIGIONGN_01792	1.29e-234	scrR	-	-	K	ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGIONGN_01793	8.08e-147	ydgI	-	-	C	-	-	-	nitroreductase
BIGIONGN_01794	3.62e-79	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_01795	2.19e-121	pat	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
BIGIONGN_01796	4.47e-178	ycsF	-	-	S	ko:K07160	-	ko00000	Belongs to the UPF0271 (lamB) family
BIGIONGN_01797	3.9e-268	ycsG	-	-	P	-	-	-	COG1914 Mn2 and Fe2 transporters of the NRAMP family
BIGIONGN_01798	1.03e-237	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
BIGIONGN_01799	2.06e-177	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
BIGIONGN_01800	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_01801	3.24e-221	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_01802	7.25e-206	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_01803	4.16e-178	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_01804	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIGIONGN_01805	1.63e-158	-	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
BIGIONGN_01807	1.05e-101	-	-	-	-	-	-	-	-
BIGIONGN_01808	0.0	gltD	1.3.1.1	-	E	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
BIGIONGN_01809	6.39e-298	preA	1.3.1.1	-	CF	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	dihydroorotate dehydrogenase
BIGIONGN_01810	0.0	hydA	3.5.2.2	-	F	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Amidohydrolase family
BIGIONGN_01811	3.91e-09	-	-	-	-	-	-	-	-
BIGIONGN_01812	3.26e-293	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
BIGIONGN_01813	0.0	-	-	-	E	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIGIONGN_01814	8.41e-88	-	-	-	F	-	-	-	PFAM AIG2 family protein
BIGIONGN_01815	6.05e-47	-	-	-	S	-	-	-	Integral membrane protein
BIGIONGN_01816	1.8e-279	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_01817	0.0	-	-	-	S	-	-	-	Hypothetical glycosyl hydrolase 6
BIGIONGN_01818	1.19e-282	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
BIGIONGN_01819	1.89e-162	-	-	-	G	-	-	-	ABC transporter permease
BIGIONGN_01820	4.59e-188	-	-	-	G	-	-	-	ABC-type polysaccharide transport system, permease component
BIGIONGN_01821	0.0	-	-	-	G	-	-	-	beta-galactosidase
BIGIONGN_01822	6.09e-296	-	-	-	S	-	-	-	Hypothetical glycosyl hydrolase 6
BIGIONGN_01823	1.68e-137	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	3-hydroxyisobutyrate dehydrogenase
BIGIONGN_01826	7.21e-226	-	-	-	S	-	-	-	Tetratricopeptide repeat
BIGIONGN_01827	0.0	-	-	-	T	-	-	-	Domain present in phytochromes and cGMP-specific phosphodiesterases.
BIGIONGN_01828	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_01829	1.11e-202	-	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
BIGIONGN_01830	3.64e-178	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
BIGIONGN_01831	4.54e-95	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
BIGIONGN_01832	1.06e-182	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	COG4464 Capsular polysaccharide biosynthesis protein
BIGIONGN_01833	3.66e-157	epsB	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
BIGIONGN_01834	1.78e-149	ywqC	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
BIGIONGN_01835	2.99e-219	tagU	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
BIGIONGN_01836	3.78e-107	-	-	-	S	-	-	-	Tetratrico peptide repeat
BIGIONGN_01837	3.16e-112	guaD	3.5.4.3	-	FJ	ko:K01487	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	COG0590 Cytosine adenosine deaminases
BIGIONGN_01838	4.6e-102	-	-	-	FG	-	-	-	Scavenger mRNA decapping enzyme C-term binding
BIGIONGN_01839	2.87e-287	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
BIGIONGN_01840	6.27e-248	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIGIONGN_01841	1.21e-215	tagU	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
BIGIONGN_01842	2.02e-61	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
BIGIONGN_01843	1.82e-296	-	-	-	-	-	-	-	-
BIGIONGN_01844	2.96e-305	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIGIONGN_01845	2.71e-298	lytE	-	-	M	-	-	-	NlpC/P60 family
BIGIONGN_01846	1.2e-195	-	-	-	Q	-	-	-	N-acetyltransferase
BIGIONGN_01847	3.37e-115	yisT	-	-	S	-	-	-	DinB family
BIGIONGN_01848	7.16e-127	-	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
BIGIONGN_01849	0.0	pip	-	-	S	ko:K01421	-	ko00000	YhgE Pip N-terminal domain protein
BIGIONGN_01850	1.09e-94	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
BIGIONGN_01851	3.57e-188	estA	-	CE1	S	ko:K03930	-	ko00000,ko01000	Putative esterase
BIGIONGN_01852	1.52e-144	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIGIONGN_01853	1.27e-248	-	-	-	S	ko:K06308	-	ko00000	Spore germination B3/ GerAC like, C-terminal
BIGIONGN_01854	1.62e-255	-	-	-	E	-	-	-	Spore germination protein
BIGIONGN_01855	0.0	-	-	-	P	-	-	-	Spore gernimation protein GerA
BIGIONGN_01856	4.62e-81	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
BIGIONGN_01857	1.68e-182	flhP	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
BIGIONGN_01858	1.05e-182	flhO	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
BIGIONGN_01859	1.9e-231	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein
BIGIONGN_01860	1.68e-60	spoIIID	-	-	K	ko:K06283	-	ko00000,ko03000	Stage III sporulation protein D
BIGIONGN_01861	2.02e-63	ykkD	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Multidrug resistance protein
BIGIONGN_01862	1.25e-69	ykkC	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Multidrug resistance protein
BIGIONGN_01863	1.07e-181	spoIIQ	-	-	M	ko:K06386	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
BIGIONGN_01864	1.03e-241	spoIID	-	-	D	ko:K06381	-	ko00000	Stage II sporulation protein D
BIGIONGN_01865	1.92e-301	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIGIONGN_01866	1.66e-21	ywmB	-	-	S	-	-	-	TATA-box binding
BIGIONGN_01867	2.09e-81	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
BIGIONGN_01868	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIGIONGN_01869	3.39e-195	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIGIONGN_01870	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIGIONGN_01871	7.09e-119	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIGIONGN_01872	2.37e-47	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIGIONGN_01873	2.78e-28	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIGIONGN_01874	3.41e-170	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
BIGIONGN_01875	1.25e-10	atpI	-	-	S	ko:K02116	-	ko00000,ko00194	ATP synthase I chain
BIGIONGN_01876	1.61e-44	-	-	-	S	-	-	-	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter
BIGIONGN_01877	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
BIGIONGN_01878	1.1e-117	panZ	-	-	K	-	-	-	-acetyltransferase
BIGIONGN_01879	5.5e-148	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIGIONGN_01880	1.07e-302	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIGIONGN_01881	3.26e-124	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
BIGIONGN_01882	7.87e-105	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase
BIGIONGN_01883	8.28e-248	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	Chemotaxis
BIGIONGN_01884	4.11e-95	ywlE	3.1.3.48, 3.9.1.2	-	T	ko:K01104,ko:K20201	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIGIONGN_01885	3.39e-121	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
BIGIONGN_01886	4.54e-77	-	-	-	S	-	-	-	Regulator of ribonuclease activity B
BIGIONGN_01887	9.58e-235	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
BIGIONGN_01888	1.36e-96	ywlB	1.20.4.1, 2.3.1.1	-	E	ko:K00537,ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetyltransferase family. ArgA subfamily
BIGIONGN_01889	7.81e-148	spoIIR	-	-	S	ko:K06387	-	ko00000	stage II sporulation protein R
BIGIONGN_01890	2.64e-208	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
BIGIONGN_01891	1.55e-232	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIGIONGN_01892	0.0	cdr	1.11.1.1	-	P	ko:K05910	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGIONGN_01893	1.19e-97	-	-	-	-	-	-	-	-
BIGIONGN_01894	1.88e-142	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
BIGIONGN_01895	2.08e-54	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
BIGIONGN_01896	2.94e-300	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIGIONGN_01897	2.21e-228	glpX	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	fructose-1,6-bisphosphatase
BIGIONGN_01898	2e-285	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIGIONGN_01899	2.81e-149	tal	2.2.1.2	-	G	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIGIONGN_01900	3.32e-206	fbaA	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Aldolase
BIGIONGN_01901	1.27e-78	spo0F	-	-	T	ko:K02490	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	response regulator
BIGIONGN_01902	1.46e-118	ywjG	-	-	S	-	-	-	Domain of unknown function (DUF2529)
BIGIONGN_01903	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
BIGIONGN_01904	6.82e-95	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
BIGIONGN_01905	4.32e-140	kstR2_2	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_01906	2.72e-261	mmgC	-	-	I	ko:K18244	-	ko00000,ko01000	acyl-CoA dehydrogenase
BIGIONGN_01907	5.91e-198	mmgB	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	Dehydrogenase
BIGIONGN_01908	5.42e-275	mmgA	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
BIGIONGN_01909	0.0	ywjF	-	-	C	-	-	-	COG0247 Fe-S oxidoreductase
BIGIONGN_01910	6.63e-278	clsB	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the phospholipase D family. Cardiolipin synthase subfamily
BIGIONGN_01911	6.53e-97	-	-	-	S	ko:K09793	-	ko00000	protein conserved in bacteria
BIGIONGN_01912	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
BIGIONGN_01913	1.89e-100	ywiB	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01914	2.02e-214	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
BIGIONGN_01915	8.83e-205	speE	2.5.1.16	-	E	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BIGIONGN_01916	0.0	pbpG	2.4.1.129, 3.4.16.4	GT51	M	ko:K21464	ko00550,map00550	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
BIGIONGN_01917	1.15e-199	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_01918	0.0	-	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
BIGIONGN_01919	5.84e-129	ywhD	-	-	S	-	-	-	YwhD family
BIGIONGN_01920	1.39e-257	-	-	-	F	-	-	-	S-adenosylhomocysteine deaminase activity
BIGIONGN_01921	5.89e-161	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
BIGIONGN_01922	5.91e-38	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	4-oxalocrotonate tautomerase
BIGIONGN_01924	8.17e-119	ywgA	-	-	-	ko:K09388	-	ko00000	-
BIGIONGN_01925	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	COG1078 HD superfamily phosphohydrolases
BIGIONGN_01926	1.32e-272	gltP	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
BIGIONGN_01927	9.45e-195	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
BIGIONGN_01928	2.13e-231	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	In Salmonella this enzyme is required for ethanolamine catabolism
BIGIONGN_01929	1.34e-183	-	5.3.3.18	-	I	ko:K15866	ko00360,ko01120,map00360,map01120	ko00000,ko00001,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
BIGIONGN_01930	1.35e-186	ywfI	-	-	C	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko01000	May function as heme-dependent peroxidase
BIGIONGN_01931	2.12e-182	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
BIGIONGN_01932	3.16e-64	-	-	-	-	-	-	-	-
BIGIONGN_01933	4.29e-252	yhaP	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	COG1668 ABC-type Na efflux pump, permease component
BIGIONGN_01934	5.34e-214	yhaQ	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_01935	1.25e-208	natA1	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_01936	9.31e-84	-	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
BIGIONGN_01937	1.01e-169	-	-	-	-	-	-	-	-
BIGIONGN_01938	1.06e-156	-	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
BIGIONGN_01939	1.38e-102	cwlJ	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell wall
BIGIONGN_01940	8.65e-107	gerQ	-	-	S	ko:K06305	-	ko00000	Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
BIGIONGN_01941	4.91e-78	ywdK	-	-	S	-	-	-	small membrane protein
BIGIONGN_01942	1.78e-146	ykwB	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_01943	0.0	putP	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIGIONGN_01944	4.39e-62	-	-	-	S	-	-	-	Family of unknown function (DUF5327)
BIGIONGN_01945	9.46e-175	polC1	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
BIGIONGN_01946	2.75e-217	-	-	-	T	ko:K07182	-	ko00000	Putative nucleotidyltransferase substrate binding domain
BIGIONGN_01947	1.68e-295	nrgA	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium transporter
BIGIONGN_01948	1.79e-226	-	-	-	S	ko:K07120	-	ko00000	Pfam:AmoA
BIGIONGN_01949	1.7e-176	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIGIONGN_01950	1.44e-303	-	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_01951	1.29e-190	pdxK	2.7.1.35, 2.7.1.49, 2.7.4.7	-	H	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
BIGIONGN_01952	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Histidine ammonia-lyase
BIGIONGN_01953	5.89e-63	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
BIGIONGN_01954	1.22e-161	-	-	-	E	-	-	-	AzlC protein
BIGIONGN_01955	0.0	gntR9	-	-	K	-	-	-	Alanine-glyoxylate amino-transferase
BIGIONGN_01956	5.03e-166	XK27_07210	-	-	S	-	-	-	B3/4 domain
BIGIONGN_01957	2.5e-300	megL	4.4.1.11	-	E	ko:K01761	ko00270,ko00450,map00270,map00450	ko00000,ko00001,ko01000	methionine gamma-lyase
BIGIONGN_01958	1.53e-243	-	-	-	I	-	-	-	Fatty acid desaturase
BIGIONGN_01959	0.0	-	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	Glutamine synthetase, catalytic domain
BIGIONGN_01960	4.45e-99	-	-	-	S	-	-	-	Protein of unknown function (DUF4064)
BIGIONGN_01961	1.56e-113	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_01962	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
BIGIONGN_01963	1.02e-103	bdbA	-	-	CO	-	-	-	Thioredoxin
BIGIONGN_01964	5.29e-95	bdbC	-	-	O	ko:K03611	-	ko00000,ko03110	Required for disulfide bond formation in some proteins
BIGIONGN_01965	0.0	yhfW	-	-	CE	-	-	-	COG0665 Glycine D-amino acid oxidases (deaminating)
BIGIONGN_01967	5.89e-109	yuaF	-	-	OU	-	-	-	Membrane protein implicated in regulation of membrane protease activity
BIGIONGN_01968	2.44e-243	yuaG	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	protein conserved in bacteria
BIGIONGN_01969	1.28e-174	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
BIGIONGN_01970	2.44e-155	ydbC	-	-	G	-	-	-	Domain of unknown function (DUF4937
BIGIONGN_01971	0.0	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
BIGIONGN_01972	0.0	topB	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIGIONGN_01973	1.73e-290	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
BIGIONGN_01974	2.81e-57	ydzA	-	-	EGP	-	-	-	Domain of unknown function (DUF3817)
BIGIONGN_01975	7.27e-73	yflT	-	-	S	-	-	-	Heat induced stress protein YflT
BIGIONGN_01976	2.48e-129	-	-	-	S	-	-	-	UPF0302 domain
BIGIONGN_01977	1.37e-192	mntD	-	-	P	ko:K11709,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
BIGIONGN_01978	3.98e-205	XK27_03890	-	-	P	ko:K11705,ko:K11708,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
BIGIONGN_01979	2.81e-180	mntB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K11710,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
BIGIONGN_01980	4.61e-224	troA	-	-	P	ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
BIGIONGN_01981	8.38e-189	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
BIGIONGN_01982	0.0	dapE	-	-	E	-	-	-	Peptidase dimerisation domain
BIGIONGN_01983	6.2e-286	-	-	-	S	-	-	-	Acetyltransferase
BIGIONGN_01984	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
BIGIONGN_01985	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIGIONGN_01986	5e-274	yxlH	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGIONGN_01987	1.09e-127	-	-	-	S	-	-	-	DinB superfamily
BIGIONGN_01988	0.0	katX	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
BIGIONGN_01989	0.0	ywjA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
BIGIONGN_01990	1.09e-221	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
BIGIONGN_01991	1.11e-141	ywrF	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIGIONGN_01992	2.7e-147	yrbG	-	-	S	-	-	-	membrane
BIGIONGN_01993	4.07e-215	bmrU	-	-	I	-	-	-	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
BIGIONGN_01995	2.31e-182	-	-	-	K	-	-	-	TipAS antibiotic-recognition domain
BIGIONGN_01996	3.01e-224	-	-	-	O	-	-	-	Predicted Zn-dependent protease (DUF2268)
BIGIONGN_01997	7.11e-116	-	-	-	K	-	-	-	GrpB protein
BIGIONGN_01998	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIGIONGN_01999	1.65e-97	-	-	-	L	-	-	-	Bacterial transcription activator, effector binding domain
BIGIONGN_02000	4.69e-161	-	-	-	-	-	-	-	-
BIGIONGN_02001	1.81e-161	-	-	-	-	-	-	-	-
BIGIONGN_02002	1.6e-159	-	-	-	-	-	-	-	-
BIGIONGN_02003	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02004	1.19e-89	-	-	-	-	-	-	-	-
BIGIONGN_02005	2.75e-91	-	-	-	-	-	-	-	-
BIGIONGN_02006	3.3e-180	-	-	-	S	-	-	-	GNAT acetyltransferase
BIGIONGN_02007	6.11e-256	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIGIONGN_02009	0.0	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02011	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02012	1.06e-155	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_02013	0.0	sdcS	-	-	P	ko:K14445	-	ko00000,ko02000	Sodium:sulfate symporter transmembrane region
BIGIONGN_02014	9.65e-157	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
BIGIONGN_02015	0.0	-	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
BIGIONGN_02016	1.4e-151	M1-740	-	-	I	-	-	-	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
BIGIONGN_02017	1.82e-226	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
BIGIONGN_02018	9.88e-82	-	-	-	S	-	-	-	CHY zinc finger
BIGIONGN_02019	4.21e-302	brnQ	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
BIGIONGN_02020	2.77e-103	sdpI	-	-	S	-	-	-	integral membrane protein
BIGIONGN_02021	8.5e-285	-	-	-	EGP	-	-	-	Transmembrane secretion effector
BIGIONGN_02022	7.98e-137	-	-	-	S	ko:K09962	-	ko00000	protein conserved in bacteria
BIGIONGN_02023	1.2e-190	ubiE	-	-	Q	-	-	-	Methyltransferase type 11
BIGIONGN_02024	2.86e-304	-	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
BIGIONGN_02025	1.32e-61	phhB	3.5.4.33, 4.2.1.96	-	H	ko:K01724,ko:K11991	ko00790,map00790	ko00000,ko00001,ko01000,ko03016,ko04147	pterin-4-alpha-carbinolamine dehydratase
BIGIONGN_02026	7.69e-87	eaeH	-	-	M	ko:K13735	ko05100,map05100	ko00000,ko00001	LysM domain
BIGIONGN_02027	2.58e-93	-	-	-	S	-	-	-	YtkA-like
BIGIONGN_02028	0.0	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02029	1.44e-156	-	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_02030	2.38e-227	-	-	-	S	-	-	-	amine dehydrogenase activity
BIGIONGN_02031	2.26e-249	-	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
BIGIONGN_02033	6.91e-45	-	-	-	-	-	-	-	-
BIGIONGN_02035	4.79e-151	M1-1017	-	-	S	-	-	-	Protein of unknown function (DUF1129)
BIGIONGN_02036	4.59e-75	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02038	1.25e-140	-	-	-	S	-	-	-	DUF218 domain
BIGIONGN_02039	8.33e-193	degV	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02040	0.0	mutS1	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
BIGIONGN_02041	4.64e-53	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIGIONGN_02042	3.5e-292	yciC	-	-	S	-	-	-	GTPases (G3E family)
BIGIONGN_02043	5.66e-168	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
BIGIONGN_02044	3.33e-241	mhqA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
BIGIONGN_02045	0.0	-	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182	ko00130,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the UbiD family
BIGIONGN_02046	1.51e-147	scoB	2.8.3.5	-	I	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
BIGIONGN_02047	1.29e-169	scoA	2.8.3.5	-	I	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BIGIONGN_02048	7.98e-309	atoE	-	-	I	ko:K02106	ko02020,map02020	ko00000,ko00001	Short chain fatty acid transporter
BIGIONGN_02049	1.92e-241	malR	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02050	7.99e-190	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
BIGIONGN_02051	0.0	-	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
BIGIONGN_02052	7.36e-309	malE	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
BIGIONGN_02053	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, N-terminal ig-like domain
BIGIONGN_02055	1.88e-311	codA	3.5.4.1	-	F	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
BIGIONGN_02056	1.25e-284	codB	-	-	F	ko:K10974	-	ko00000,ko02000	cytosine purines uracil thiamine allantoin
BIGIONGN_02058	0.0	-	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
BIGIONGN_02059	5.37e-292	lhgO	1.1.5.3	-	S	ko:K00111,ko:K15736	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	FAD dependent oxidoreductase
BIGIONGN_02060	0.0	-	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
BIGIONGN_02061	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
BIGIONGN_02062	2.56e-162	-	-	-	K	-	-	-	COG2186 Transcriptional regulators
BIGIONGN_02063	1.26e-155	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
BIGIONGN_02064	0.0	-	-	-	S	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
BIGIONGN_02065	2.94e-237	-	-	-	S	ko:K07080	-	ko00000	NMT1-like family
BIGIONGN_02066	4.53e-206	citR	-	-	K	ko:K19242	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02067	5.93e-261	citA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
BIGIONGN_02068	8.5e-271	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
BIGIONGN_02069	2.99e-98	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_02070	5.92e-236	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_02071	2.11e-149	kdgR	-	-	K	-	-	-	FCD
BIGIONGN_02072	1.67e-251	yjmC	1.1.1.350	-	C	ko:K00073	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000	Belongs to the LDH2 MDH2 oxidoreductase family
BIGIONGN_02073	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
BIGIONGN_02074	6.25e-117	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_02075	2.92e-126	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
BIGIONGN_02076	9.44e-236	-	-	-	S	-	-	-	Domain of unknown function (DUF4179)
BIGIONGN_02077	4.83e-98	-	-	-	S	-	-	-	Domain of unknown function (DU1801)
BIGIONGN_02078	3.45e-150	-	-	-	S	-	-	-	CGNR zinc finger
BIGIONGN_02079	1.4e-109	-	-	-	-	-	-	-	-
BIGIONGN_02080	0.0	-	-	-	T	-	-	-	Carbon starvation protein
BIGIONGN_02081	5.2e-173	-	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
BIGIONGN_02082	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_02083	1.26e-136	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02084	0.0	ydfJ	-	-	S	ko:K07003	-	ko00000	MMPL family
BIGIONGN_02085	1.44e-261	-	-	-	S	-	-	-	domain protein
BIGIONGN_02086	1.49e-227	oppF3	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_02087	1.19e-230	oppD3	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_02088	1.78e-212	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_02089	1.88e-223	appB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_02090	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
BIGIONGN_02091	5.96e-12	-	-	-	-	-	-	-	-
BIGIONGN_02092	1.08e-176	-	-	-	S	-	-	-	Sulfite exporter TauE/SafE
BIGIONGN_02094	5.39e-144	-	-	-	S	-	-	-	ABC-2 family transporter protein
BIGIONGN_02095	9.72e-192	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_02097	4.51e-156	-	-	-	G	-	-	-	Class II Aldolase and Adducin N-terminal domain
BIGIONGN_02098	4e-267	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
BIGIONGN_02099	1.83e-101	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_02100	6.93e-236	-	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
BIGIONGN_02101	4.19e-240	tdh	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
BIGIONGN_02102	1.46e-142	-	-	-	K	-	-	-	FCD domain
BIGIONGN_02103	6.6e-311	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
BIGIONGN_02104	5.1e-11	-	-	-	-	-	-	-	-
BIGIONGN_02105	3.88e-158	-	-	-	Q	ko:K15256	-	ko00000,ko01000,ko03016	O-methyltransferase
BIGIONGN_02106	2.15e-81	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
BIGIONGN_02109	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIGIONGN_02110	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIGIONGN_02111	1.39e-110	-	-	-	L	-	-	-	Type I restriction modification DNA specificity domain
BIGIONGN_02112	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	Type I restriction-modification system
BIGIONGN_02114	1.13e-102	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIGIONGN_02115	6.79e-12	-	-	-	S	-	-	-	YyzF-like protein
BIGIONGN_02116	2.55e-270	yyxA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIGIONGN_02117	2.32e-190	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
BIGIONGN_02118	6.5e-214	yycI	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02119	0.0	yycH	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02120	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_02121	7.17e-171	yycF	-	-	T	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_02127	1.94e-316	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIGIONGN_02128	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
BIGIONGN_02129	1.71e-89	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
BIGIONGN_02130	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIGIONGN_02131	7.84e-191	yybS	-	-	S	-	-	-	membrane
BIGIONGN_02132	4.32e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIGIONGN_02133	4.35e-92	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
BIGIONGN_02134	3.39e-60	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
BIGIONGN_02135	5.67e-246	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
BIGIONGN_02136	1.19e-37	yyzM	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02137	1.43e-230	yyaD	-	-	S	-	-	-	Membrane
BIGIONGN_02138	7.22e-149	yyaC	-	-	S	-	-	-	Sporulation protein YyaC
BIGIONGN_02139	8.01e-276	-	-	-	E	-	-	-	Aminotransferase class-V
BIGIONGN_02140	7.4e-195	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
BIGIONGN_02141	2.04e-174	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	COG1192 ATPases involved in chromosome partitioning
BIGIONGN_02142	2.58e-192	noc	-	-	D	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
BIGIONGN_02143	7.14e-167	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
BIGIONGN_02144	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
BIGIONGN_02145	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIGIONGN_02146	2.51e-145	jag	-	-	S	ko:K06346	-	ko00000	single-stranded nucleic acid binding R3H
BIGIONGN_02147	2.14e-178	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
BIGIONGN_02148	8.89e-80	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
BIGIONGN_02149	2.52e-22	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
BIGIONGN_02150	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIGIONGN_02151	4.21e-265	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
BIGIONGN_02152	9.82e-45	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain
BIGIONGN_02153	1.98e-259	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIGIONGN_02154	2.79e-11	yqbO1	-	-	S	-	-	-	Domain of unknown function (DUF370)
BIGIONGN_02155	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIGIONGN_02156	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIGIONGN_02157	9.09e-235	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_02158	1.9e-125	bcrC	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Bacitracin ABC transporter permease
BIGIONGN_02159	3.57e-202	kbaY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
BIGIONGN_02160	9.17e-100	fruD	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGIONGN_02161	0.0	fruC	2.7.1.202	-	G	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGIONGN_02162	3.94e-221	fruK-1	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
BIGIONGN_02163	6.56e-182	rpl	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
BIGIONGN_02164	1.31e-212	XK27_03180	-	-	T	-	-	-	Belongs to the universal stress protein A family
BIGIONGN_02166	6.11e-68	-	-	-	-	-	-	-	-
BIGIONGN_02167	1.49e-74	-	-	-	-	-	-	-	-
BIGIONGN_02168	8.98e-253	-	-	-	E	ko:K02055	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0687 Spermidine putrescine-binding periplasmic protein
BIGIONGN_02169	8.64e-225	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
BIGIONGN_02170	7.59e-180	-	-	-	E	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1176 ABC-type spermidine putrescine transport system, permease component I
BIGIONGN_02171	2.09e-172	potC3	-	-	P	ko:K02053	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02172	8.94e-250	potA11	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
BIGIONGN_02173	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Adenine deaminase C-terminal domain
BIGIONGN_02174	0.0	M1-554	-	-	G	-	-	-	Endonuclease Exonuclease Phosphatase
BIGIONGN_02175	2.39e-18	-	-	-	S	-	-	-	Inner spore coat protein D
BIGIONGN_02176	2.08e-81	-	-	-	FJ	-	-	-	tRNA wobble adenosine to inosine editing
BIGIONGN_02177	1.57e-201	-	-	-	P	ko:K02026,ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
BIGIONGN_02178	2.52e-206	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02179	3.49e-310	-	-	-	G	-	-	-	ABC transporter substrate-binding protein
BIGIONGN_02180	1.41e-239	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
BIGIONGN_02181	0.0	ltaS	2.7.8.20	-	M	ko:K01138,ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
BIGIONGN_02182	4.63e-175	lacR	-	-	K	ko:K02530	-	ko00000,ko03000	DeoR C terminal sensor domain
BIGIONGN_02183	4.39e-289	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIGIONGN_02184	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
BIGIONGN_02185	9.24e-220	-	-	-	Q	-	-	-	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BIGIONGN_02186	1.57e-187	-	-	-	C	-	-	-	lyase activity
BIGIONGN_02187	0.0	mdr	-	-	EGP	-	-	-	the major facilitator superfamily
BIGIONGN_02188	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
BIGIONGN_02189	8.9e-216	gmuE	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	COG1940 Transcriptional regulator sugar kinase
BIGIONGN_02190	1.07e-65	-	-	-	-	-	-	-	-
BIGIONGN_02191	3.63e-172	yvcP	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_02192	2.27e-247	yvcQ	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
BIGIONGN_02193	6.61e-183	yxdL_2	-	-	V	ko:K02003,ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_02194	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
BIGIONGN_02196	0.0	-	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
BIGIONGN_02197	9.9e-208	-	-	-	S	-	-	-	CAAX amino terminal protease family protein
BIGIONGN_02198	2.66e-220	-	-	-	K	-	-	-	Putative sugar-binding domain
BIGIONGN_02199	5.44e-79	-	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
BIGIONGN_02200	7.47e-235	-	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol sorbitol-specific transporter subunit IIB
BIGIONGN_02201	8.78e-115	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
BIGIONGN_02202	1.9e-89	-	-	-	K	-	-	-	Glucitol operon activator protein (GutM)
BIGIONGN_02203	1.07e-300	-	-	-	E	-	-	-	SAF
BIGIONGN_02204	2.05e-51	-	-	-	G	-	-	-	PTS HPr component phosphorylation site
BIGIONGN_02205	1.13e-157	-	-	-	-	-	-	-	-
BIGIONGN_02206	7.02e-122	-	-	-	S	-	-	-	VanZ like family
BIGIONGN_02207	6.71e-102	yybA	-	-	K	-	-	-	transcriptional
BIGIONGN_02208	2.42e-122	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_02209	5.17e-223	ssuA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
BIGIONGN_02210	2.49e-134	ssuC_2	-	-	P	ko:K02050,ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02211	8.1e-199	ssuB	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
BIGIONGN_02212	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
BIGIONGN_02213	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
BIGIONGN_02214	6.97e-264	cdaR_1	-	-	KT	ko:K02647	-	ko00000,ko03000	regulator
BIGIONGN_02215	1.69e-296	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	COG2270 Permeases of the major facilitator superfamily
BIGIONGN_02216	5.58e-183	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
BIGIONGN_02217	1.1e-197	-	-	-	S	-	-	-	Tetratricopeptide repeat
BIGIONGN_02218	1.44e-228	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
BIGIONGN_02220	0.0	-	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
BIGIONGN_02221	8.74e-67	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_02222	1.2e-151	-	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
BIGIONGN_02223	7.02e-106	-	-	-	-	-	-	-	-
BIGIONGN_02224	4.07e-13	malR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02225	2.58e-163	-	-	-	S	-	-	-	KR domain
BIGIONGN_02226	2.73e-69	-	-	-	S	-	-	-	Family of unknown function (DUF5367)
BIGIONGN_02227	1.16e-133	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_02228	1.11e-208	-	-	-	EG	-	-	-	EamA-like transporter family
BIGIONGN_02229	0.0	ywoF	-	-	P	-	-	-	Right handed beta helix region
BIGIONGN_02230	9.48e-125	mutT	3.6.1.13, 3.6.1.55	-	L	ko:K01515,ko:K03574	ko00230,map00230	ko00000,ko00001,ko01000,ko03400	nUDIX hydrolase
BIGIONGN_02232	1.93e-79	-	-	-	S	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGIONGN_02233	2.15e-145	-	-	-	M	-	-	-	Peptidase family M23
BIGIONGN_02234	0.0	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
BIGIONGN_02235	8.63e-190	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02236	1.78e-209	-	-	-	G	-	-	-	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02237	1.41e-273	-	3.2.1.180	GH88	O	ko:K18581	-	ko00000,ko01000	Glycosyl Hydrolase Family 88
BIGIONGN_02238	4.09e-219	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_02239	6.74e-290	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_02240	6.01e-270	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_02241	7.62e-133	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_02242	2.32e-184	inoDHR	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_02243	3.44e-199	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02244	3.93e-220	ugpA7	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02245	0.0	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
BIGIONGN_02246	2.45e-268	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_02247	5.46e-181	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_02248	8.28e-222	-	-	-	K	-	-	-	Cupin domain
BIGIONGN_02249	1.86e-243	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_02250	8.79e-86	-	-	-	S	-	-	-	Protein of unknown function, DUF393
BIGIONGN_02251	3.31e-206	yfhB	-	-	S	-	-	-	PhzF family
BIGIONGN_02252	5.71e-132	-	-	-	V	-	-	-	Beta-lactamase
BIGIONGN_02253	8.62e-120	plsY1	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
BIGIONGN_02254	0.0	-	-	-	E	-	-	-	Aminotransferase class-V
BIGIONGN_02255	0.0	-	-	-	M	-	-	-	Sulfatase
BIGIONGN_02256	3.39e-91	-	-	-	E	ko:K07032	-	ko00000	lactoylglutathione lyase activity
BIGIONGN_02257	4.69e-200	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
BIGIONGN_02259	1.72e-213	yjfC	-	-	O	-	-	-	Predicted Zn-dependent protease (DUF2268)
BIGIONGN_02260	4.83e-202	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
BIGIONGN_02261	1.45e-45	yisX	-	-	S	-	-	-	Pentapeptide repeats (9 copies)
BIGIONGN_02262	3.03e-190	araQ	-	-	P	ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
BIGIONGN_02263	8.45e-206	-	-	-	G	ko:K10189	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02264	8.98e-311	-	-	-	G	ko:K10188	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_02265	2.72e-67	-	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
BIGIONGN_02266	3.11e-153	-	-	-	E	-	-	-	AzlC protein
BIGIONGN_02267	7.81e-128	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_02268	1.21e-120	M1-753	-	-	M	-	-	-	FR47-like protein
BIGIONGN_02269	1.69e-184	rrmA	2.1.1.187	-	Q	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase domain
BIGIONGN_02271	5.27e-49	ydaS	-	-	S	-	-	-	membrane
BIGIONGN_02272	1.01e-123	ywmF	-	-	S	-	-	-	Peptidase M50
BIGIONGN_02273	3.79e-309	-	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
BIGIONGN_02274	2.15e-153	ypgQ	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
BIGIONGN_02275	2.53e-38	-	-	-	-	-	-	-	-
BIGIONGN_02276	0.0	apc3	-	-	EQ	-	-	-	Hydantoinase/oxoprolinase
BIGIONGN_02277	1.07e-263	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
BIGIONGN_02278	1.33e-279	-	-	-	F	ko:K10974	-	ko00000,ko02000	cytosine purines uracil thiamine allantoin
BIGIONGN_02279	3.06e-135	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_02280	3.64e-180	-	-	-	K	-	-	-	acetyltransferase
BIGIONGN_02281	1.77e-108	-	-	-	S	ko:K06385	-	ko00000	Stage II sporulation protein P (SpoIIP)
BIGIONGN_02282	2.01e-211	-	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	Protein kinase domain
BIGIONGN_02283	1.68e-76	-	-	-	FG	ko:K02503	-	ko00000,ko04147	HIT domain
BIGIONGN_02284	3.43e-234	ydhJ	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGIONGN_02285	4.75e-07	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02286	4.61e-125	-	-	-	S	ko:K06361,ko:K06365,ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
BIGIONGN_02287	2.61e-122	-	-	-	-	-	-	-	-
BIGIONGN_02289	3.04e-233	-	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
BIGIONGN_02290	5.73e-301	-	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02291	0.0	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
BIGIONGN_02292	1.02e-285	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
BIGIONGN_02293	0.0	hutI	3.5.2.7	-	Q	ko:K01468	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Imidazolone-5-propionate hydrolase
BIGIONGN_02294	0.0	hutU	4.2.1.49	-	E	ko:K01712	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BIGIONGN_02295	0.0	-	-	-	T	-	-	-	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
BIGIONGN_02296	1.99e-281	-	-	-	G	-	-	-	Transmembrane secretion effector
BIGIONGN_02297	2.68e-253	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_02298	2.84e-137	desR	-	-	K	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
BIGIONGN_02299	2.32e-153	-	-	-	-	-	-	-	-
BIGIONGN_02300	5.5e-200	-	-	-	K	ko:K03488	-	ko00000,ko03000	antiterminator
BIGIONGN_02301	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
BIGIONGN_02302	7.39e-224	-	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
BIGIONGN_02303	1.01e-130	ydhK	-	-	M	-	-	-	Protein of unknown function (DUF1541)
BIGIONGN_02304	1.83e-92	-	-	-	-	-	-	-	-
BIGIONGN_02305	0.0	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
BIGIONGN_02306	1.36e-265	gatD	1.1.1.14, 1.1.1.251	-	C	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	ko00000,ko00001,ko00002,ko01000	Alcohol dehydrogenase GroES-like domain
BIGIONGN_02307	1.15e-29	-	-	-	-	-	-	-	-
BIGIONGN_02308	4.25e-248	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
BIGIONGN_02309	6.01e-287	gatC	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	COG3775 Phosphotransferase system, galactitol-specific IIC component
BIGIONGN_02310	3.67e-57	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGIONGN_02311	2.73e-104	-	2.7.1.200	-	GT	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGIONGN_02312	0.0	-	-	-	GKT	-	-	-	COG3711 Transcriptional antiterminator
BIGIONGN_02313	0.0	zosA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
BIGIONGN_02314	1.97e-255	-	-	-	-	-	-	-	-
BIGIONGN_02315	7.47e-141	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	3-hexulose-6-phosphate synthase
BIGIONGN_02316	6.83e-225	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
BIGIONGN_02317	1.85e-144	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BIGIONGN_02318	7.67e-124	hxlB	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
BIGIONGN_02319	1.38e-264	siaT_3	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
BIGIONGN_02320	9.62e-111	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_02321	8.05e-233	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_02322	1.02e-235	regR	-	-	K	ko:K02525	-	ko00000,ko03000	transcriptional
BIGIONGN_02323	4.89e-70	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
BIGIONGN_02324	8.01e-97	-	-	-	-	-	-	-	-
BIGIONGN_02325	8.2e-104	-	-	-	-	-	-	-	-
BIGIONGN_02326	2.8e-255	ysdC_3	3.2.1.4	GH5,GH9	G	ko:K01179	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	M42 glutamyl aminopeptidase
BIGIONGN_02327	7.46e-59	M1-485	-	-	S	-	-	-	Membrane
BIGIONGN_02328	4.89e-70	yvdC	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
BIGIONGN_02329	5.41e-235	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
BIGIONGN_02330	6.61e-187	tagG	-	-	GM	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
BIGIONGN_02331	7.76e-188	-	-	-	S	ko:K06976	-	ko00000	GNAT acetyltransferase
BIGIONGN_02332	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
BIGIONGN_02333	0.0	yxiA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
BIGIONGN_02334	3.97e-35	-	-	-	-	-	-	-	-
BIGIONGN_02335	0.0	xsa	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	Alpha-L-arabinofuranosidase C-terminus
BIGIONGN_02336	6.34e-178	modA	-	-	P	ko:K02020	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0725 ABC-type molybdate transport system, periplasmic component
BIGIONGN_02337	3.63e-143	modB	-	-	P	ko:K02018	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4149 ABC-type molybdate transport system, permease component
BIGIONGN_02338	9.41e-140	vraR	-	-	KT	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
BIGIONGN_02339	4.22e-245	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_02340	7.66e-163	yvqF	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
BIGIONGN_02341	7.92e-134	-	-	-	-	-	-	-	-
BIGIONGN_02342	2.51e-06	liaI	-	-	-	ko:K11619	ko02020,map02020	ko00000,ko00001,ko00002	-
BIGIONGN_02343	1.01e-48	-	-	-	-	-	-	-	-
BIGIONGN_02344	2.46e-150	-	-	-	S	-	-	-	Cupin
BIGIONGN_02345	0.0	-	-	-	M	-	-	-	glycoside hydrolase family 81
BIGIONGN_02346	7.61e-247	cytR	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGIONGN_02347	3.83e-165	glpF	-	-	G	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
BIGIONGN_02348	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIGIONGN_02349	7.97e-222	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_02350	1.1e-228	-	-	-	K	-	-	-	WYL domain
BIGIONGN_02351	6.68e-147	-	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIGIONGN_02352	1.5e-197	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BIGIONGN_02353	5.01e-202	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	COG1230 Co Zn Cd efflux system component
BIGIONGN_02354	8.37e-66	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	transcriptional
BIGIONGN_02355	5.77e-214	gltC	-	-	K	ko:K09681	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02356	0.0	gdhA	1.4.1.2, 1.4.1.4	-	E	ko:K00260,ko:K00262	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
BIGIONGN_02357	6.85e-179	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
BIGIONGN_02358	4.27e-225	-	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_02359	2.3e-259	-	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
BIGIONGN_02360	1.33e-176	ssuB	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
BIGIONGN_02361	2.15e-75	-	-	-	S	-	-	-	Dinitrogenase iron-molybdenum cofactor
BIGIONGN_02362	1.53e-315	yxeK	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIGIONGN_02363	4.27e-120	ssuE	1.5.1.38	-	S	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	ko00000,ko00001,ko01000	FMN reductase
BIGIONGN_02364	5.3e-209	ytlI3	-	-	K	ko:K21960	-	ko00000,ko03000	LysR substrate binding domain
BIGIONGN_02365	6.99e-112	ypmQ	-	-	S	ko:K07152	-	ko00000,ko03029	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
BIGIONGN_02366	5e-152	-	-	-	S	-	-	-	membrane
BIGIONGN_02367	1.03e-37	-	-	-	S	-	-	-	spore protein
BIGIONGN_02368	4.37e-39	-	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
BIGIONGN_02369	0.0	swrC	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIGIONGN_02371	7.78e-202	yerO	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02372	1.88e-163	-	-	-	-	-	-	-	-
BIGIONGN_02373	5.33e-210	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGIONGN_02374	8.89e-80	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
BIGIONGN_02375	9.53e-147	-	-	-	Q	-	-	-	Methyltransferase domain
BIGIONGN_02376	4.82e-185	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
BIGIONGN_02377	2.54e-10	-	-	-	-	-	-	-	-
BIGIONGN_02378	2.94e-285	fdh	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
BIGIONGN_02379	2.02e-215	yflN	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
BIGIONGN_02380	4.8e-222	-	-	-	P	ko:K07217	-	ko00000	Catalase
BIGIONGN_02381	0.0	-	-	-	S	-	-	-	Predicted membrane protein (DUF2254)
BIGIONGN_02382	1.03e-208	-	-	-	E	ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycine betaine ABC transporter
BIGIONGN_02383	2.75e-306	-	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
BIGIONGN_02384	2.06e-184	srtB	3.4.22.70	-	S	ko:K08600	-	ko00000,ko01000,ko01002,ko01011	Sortase family
BIGIONGN_02385	7.35e-174	fepC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_02386	2.34e-217	fhuB11	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_02387	1.64e-209	isdE	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_02388	0.0	-	-	-	M	-	-	-	Cell surface protein
BIGIONGN_02389	1.96e-156	isdC	-	-	M	-	-	-	NEAr Transporter domain
BIGIONGN_02390	2.94e-71	isdG	1.14.99.48	-	C	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron
BIGIONGN_02391	8.18e-222	fhuG7	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_02392	2.98e-219	fhuD11	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
BIGIONGN_02393	6.17e-286	adhB	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
BIGIONGN_02394	2.5e-188	-	-	-	S	-	-	-	Methyltransferase domain
BIGIONGN_02395	3.06e-144	-	-	-	K	-	-	-	Bacterial transcriptional repressor C-terminal
BIGIONGN_02396	0.0	-	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	the major facilitator superfamily
BIGIONGN_02397	4.3e-295	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
BIGIONGN_02398	5.26e-163	yxjF	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
BIGIONGN_02399	1.4e-199	gltR3	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_02400	1.69e-232	-	3.8.1.3	-	S	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Alpha/beta hydrolase family
BIGIONGN_02401	1.58e-200	-	5.1.3.22	-	G	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Xylose isomerase-like TIM barrel
BIGIONGN_02402	7.51e-238	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_02403	5.53e-242	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_02404	1.57e-189	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02405	8.54e-218	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02406	4.41e-309	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_02407	5.15e-289	-	-	-	GK	-	-	-	ROK family
BIGIONGN_02408	1.3e-281	-	-	-	P	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
BIGIONGN_02409	1.1e-86	yqiX	-	-	S	-	-	-	YolD-like protein
BIGIONGN_02411	3.02e-06	sda	-	-	S	ko:K06371	-	ko00000	sporulation
BIGIONGN_02412	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
BIGIONGN_02413	2.64e-63	-	-	-	-	-	-	-	-
BIGIONGN_02414	3.14e-113	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
BIGIONGN_02415	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
BIGIONGN_02416	0.0	-	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase
BIGIONGN_02417	8.28e-255	dctP	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
BIGIONGN_02418	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02419	9.91e-222	yjlA	-	-	EG	-	-	-	Putative multidrug resistance efflux transporter
BIGIONGN_02420	1.1e-228	isp	-	-	O	ko:K13275	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
BIGIONGN_02421	2.63e-161	yoqW	-	-	S	-	-	-	Belongs to the SOS response-associated peptidase family
BIGIONGN_02424	9.21e-212	-	-	-	V	-	-	-	VanW like protein
BIGIONGN_02425	1.99e-124	-	-	-	V	-	-	-	(ABC) transporter
BIGIONGN_02426	2.06e-61	-	-	-	K	ko:K10947	-	ko00000,ko03000	PadR family transcriptional regulator
BIGIONGN_02427	6.33e-157	yqeB	-	-	-	-	-	-	-
BIGIONGN_02428	4.92e-136	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_02429	3.54e-193	yojH	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
BIGIONGN_02430	0.0	-	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIGIONGN_02431	1.46e-112	-	1.8.5.2	-	S	ko:K16937	ko00920,ko01120,map00920,map01120	ko00000,ko00001,ko01000	DoxX
BIGIONGN_02432	3.28e-28	-	-	-	-	-	-	-	-
BIGIONGN_02433	5.79e-76	-	-	-	-	-	-	-	-
BIGIONGN_02434	2.37e-124	-	-	-	K	ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
BIGIONGN_02436	4.59e-198	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
BIGIONGN_02437	8.17e-242	-	-	-	G	-	-	-	Xylose isomerase
BIGIONGN_02438	3.93e-184	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02439	2.95e-212	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02440	1.29e-300	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_02441	5.72e-238	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_02442	4.74e-243	-	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
BIGIONGN_02443	1.32e-80	-	-	-	S	-	-	-	Ketosteroid isomerase-related protein
BIGIONGN_02444	4.33e-189	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGIONGN_02445	2.14e-232	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_02446	9.12e-199	dkgB	-	-	S	-	-	-	Aldo/keto reductase family
BIGIONGN_02447	6.2e-241	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGIONGN_02448	2.7e-312	hemAT	-	-	NT	ko:K06595	-	ko00000,ko02035	chemotaxis protein
BIGIONGN_02449	2.47e-178	-	-	-	S	-	-	-	Nucleotidyltransferase domain
BIGIONGN_02450	7e-196	-	3.5.2.6	-	V	ko:K17838	ko01501,map01501	ko00000,ko00001,ko01000	beta-lactamase
BIGIONGN_02451	1.15e-163	-	-	-	KT	-	-	-	Forkhead associated domain
BIGIONGN_02452	7.13e-313	amaB_2	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
BIGIONGN_02453	3.08e-204	yuiI	-	-	S	ko:K07017	-	ko00000	Putative esterase
BIGIONGN_02454	1.51e-236	feuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_02455	2.3e-232	feuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_02456	5.59e-224	feuA	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Iron-uptake system-binding protein
BIGIONGN_02457	0.0	ybbB	-	-	K	ko:K21701	-	ko00000,ko03000	COG2207 AraC-type DNA-binding domain-containing proteins
BIGIONGN_02458	8.69e-230	ectD	1.14.11.55	-	Q	ko:K10674	ko00260,ko01120,map00260,map01120	ko00000,ko00001,ko01000	Phytanoyl-CoA dioxygenase (PhyH)
BIGIONGN_02459	2.59e-257	-	-	-	-	-	-	-	-
BIGIONGN_02460	0.0	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
BIGIONGN_02461	5.78e-247	gerKB	-	-	E	-	-	-	Spore germination protein
BIGIONGN_02462	2.72e-262	gerKC	-	-	S	-	-	-	Spore germination B3/ GerAC like, C-terminal
BIGIONGN_02463	0.0	bceB	-	-	V	ko:K11632,ko:K19080	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter (permease)
BIGIONGN_02464	6.09e-175	bceA	-	-	V	ko:K02003,ko:K11631,ko:K19079	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_02465	2.29e-299	msmE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_02466	3.71e-155	msmF3	-	-	P	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02467	6.07e-186	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
BIGIONGN_02468	0.0	-	-	-	S	-	-	-	Chlorophyllase enzyme
BIGIONGN_02469	1.56e-82	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
BIGIONGN_02470	2.61e-107	-	-	-	GKT	-	-	-	Mga helix-turn-helix domain
BIGIONGN_02471	0.0	-	-	-	GKT	-	-	-	Mga helix-turn-helix domain
BIGIONGN_02472	9.8e-234	-	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
BIGIONGN_02473	2.25e-60	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
BIGIONGN_02474	4.42e-274	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
BIGIONGN_02475	3.3e-200	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
BIGIONGN_02476	7.71e-133	-	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
BIGIONGN_02477	3.01e-09	gsiB	-	-	S	ko:K06884	-	ko00000	general stress protein
BIGIONGN_02478	1.16e-203	-	2.1.1.184	-	J	ko:K00561	-	br01600,ko00000,ko01000,ko01504,ko03009	Ribosomal RNA adenine dimethylases
BIGIONGN_02479	6.41e-77	-	-	-	S	-	-	-	Domain of unknown function (DUF4260)
BIGIONGN_02480	8.65e-92	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_02481	1.83e-257	-	6.3.5.5	-	S	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	ATP-grasp domain
BIGIONGN_02482	1.86e-267	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Peptidase dimerisation domain
BIGIONGN_02483	1.15e-130	-	-	-	S	-	-	-	DinB superfamily
BIGIONGN_02485	3.45e-165	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02486	0.0	lacA	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	beta-galactosidase
BIGIONGN_02487	2.6e-301	yvfO	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
BIGIONGN_02488	3.52e-191	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
BIGIONGN_02489	1.5e-314	malC	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
BIGIONGN_02490	7.26e-304	cycB	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
BIGIONGN_02491	1.58e-237	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02492	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02493	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02494	2.68e-129	-	-	-	-	-	-	-	-
BIGIONGN_02495	4.31e-198	yxxF	-	-	EG	-	-	-	EamA-like transporter family
BIGIONGN_02496	4.15e-191	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02497	7.34e-142	-	-	-	S	-	-	-	ABC-2 family transporter protein
BIGIONGN_02498	3.42e-198	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_02499	4.51e-236	ybfP	-	-	K	ko:K13653	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02500	3.31e-240	-	-	-	E	-	-	-	Amidinotransferase
BIGIONGN_02501	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
BIGIONGN_02502	3.4e-175	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_02503	5.64e-254	-	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
BIGIONGN_02504	5.54e-286	-	-	-	S	-	-	-	Erythromycin esterase
BIGIONGN_02505	2.46e-118	ykuD	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02506	1.27e-231	-	-	-	S	-	-	-	Choline/ethanolamine kinase
BIGIONGN_02507	4.14e-72	-	-	-	-	-	-	-	-
BIGIONGN_02508	0.0	-	-	-	-	-	-	-	-
BIGIONGN_02509	5.02e-150	-	-	-	-	-	-	-	-
BIGIONGN_02510	3.34e-80	-	-	-	K	-	-	-	MerR, DNA binding
BIGIONGN_02511	3.03e-193	-	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_02512	1.95e-90	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02513	4.03e-99	-	-	-	-	-	-	-	-
BIGIONGN_02514	1.14e-205	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	COG1879 ABC-type sugar transport system, periplasmic component
BIGIONGN_02515	1.62e-206	rbsC	-	-	G	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGIONGN_02516	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
BIGIONGN_02517	1.62e-83	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
BIGIONGN_02518	9.82e-202	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIGIONGN_02519	6.64e-233	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
BIGIONGN_02520	1.81e-225	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
BIGIONGN_02522	5.23e-92	-	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Helix-hairpin-helix motif
BIGIONGN_02523	0.0	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
BIGIONGN_02524	1.63e-161	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
BIGIONGN_02525	4.4e-170	-	-	-	-	-	-	-	-
BIGIONGN_02526	2.06e-173	-	-	-	S	-	-	-	ABC-2 family transporter protein
BIGIONGN_02527	3.66e-166	pstB13	-	-	V	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
BIGIONGN_02528	3.93e-134	-	-	-	H	-	-	-	Flavoprotein
BIGIONGN_02529	0.0	spaC1	-	-	V	ko:K20484	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lanthionine synthetase C-like protein
BIGIONGN_02530	0.0	bsaB	-	-	S	ko:K20483	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lantibiotic dehydratase, C terminus
BIGIONGN_02532	4.11e-222	XK27_06795	-	-	K	ko:K20391	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
BIGIONGN_02533	0.0	yvcC1	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
BIGIONGN_02536	1.04e-71	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_02537	7.57e-135	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
BIGIONGN_02538	0.0	-	-	-	M	-	-	-	cell wall anchor domain
BIGIONGN_02539	6.6e-99	-	-	-	T	-	-	-	Bacterial transcriptional activator domain
BIGIONGN_02540	9.52e-262	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02542	1.4e-226	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_02543	2.23e-249	rspA	4.2.1.8	-	M	ko:K08323	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
BIGIONGN_02544	1.15e-117	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGIONGN_02545	3.22e-26	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIGIONGN_02546	0.0	ramA	3.2.1.40	-	G	ko:K05989	-	ko00000,ko01000	Alpha-L-rhamnosidase
BIGIONGN_02547	6.73e-135	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02548	4.61e-150	-	-	-	G	-	-	-	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02549	4.06e-167	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
BIGIONGN_02551	3.46e-48	-	-	-	T	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_02552	2.3e-151	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02553	6.03e-94	-	-	-	S	-	-	-	Sulfite exporter TauE/SafE
BIGIONGN_02554	6.27e-153	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02555	0.0	pps	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
BIGIONGN_02556	5.53e-91	yqjY	-	-	K	ko:K06977	-	ko00000	Acetyltransferase (GNAT) domain
BIGIONGN_02559	0.0	-	-	-	C	-	-	-	FAD dependent oxidoreductase
BIGIONGN_02560	9.39e-192	ugpE3	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02561	1.22e-219	-	-	-	U	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02562	1.27e-314	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_02563	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_02564	1.75e-173	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
BIGIONGN_02565	0.0	-	-	-	G	-	-	-	beta-fructofuranosidase activity
BIGIONGN_02566	1.11e-96	-	-	-	L	ko:K07451,ko:K07452	-	ko00000,ko01000,ko02048	HNH endonuclease
BIGIONGN_02567	2.19e-61	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIGIONGN_02568	1.37e-249	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIGIONGN_02569	1.13e-152	cas4	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	RecB family exonuclease
BIGIONGN_02570	1.3e-202	csd2	-	-	L	ko:K19115,ko:K19118	-	ko00000,ko02048	CRISPR-associated protein Cas7
BIGIONGN_02571	0.0	csd1	-	-	M	ko:K19117	-	ko00000,ko02048	CRISPR-associated protein (Cas_Csd1)
BIGIONGN_02572	1.7e-178	cas5	-	-	S	ko:K19119	-	ko00000,ko02048	CRISPR-associated protein (Cas_Cas5)
BIGIONGN_02574	0.0	-	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGIONGN_02575	8.07e-163	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
BIGIONGN_02576	0.0	-	-	-	M	-	-	-	Belongs to the BCCT transporter (TC 2.A.15) family
BIGIONGN_02578	1.1e-103	-	-	-	S	-	-	-	yiaA/B two helix domain
BIGIONGN_02579	4.81e-226	-	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Bacterial fructose-1,6-bisphosphatase, glpX-encoded
BIGIONGN_02580	4.34e-145	-	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
BIGIONGN_02581	3.89e-241	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
BIGIONGN_02582	6.17e-104	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose/Galactose Isomerase
BIGIONGN_02583	1.08e-172	-	-	-	K	-	-	-	DeoR C terminal sensor domain
BIGIONGN_02584	3.23e-173	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_02585	5.56e-270	-	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
BIGIONGN_02586	1.12e-303	yoaB	-	-	EGP	-	-	-	the major facilitator superfamily
BIGIONGN_02587	7.92e-74	-	-	-	S	ko:K07068	-	ko00000	DUF35 OB-fold domain, acyl-CoA-associated
BIGIONGN_02588	9.88e-263	-	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Thiolase, C-terminal domain
BIGIONGN_02589	0.0	-	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
BIGIONGN_02590	2.25e-118	-	-	-	S	-	-	-	DNA-binding protein with PD1-like DNA-binding motif
BIGIONGN_02591	6.34e-179	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_02592	9.26e-278	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
BIGIONGN_02593	9.44e-110	-	-	-	G	ko:K11689	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_02594	9.99e-246	-	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
BIGIONGN_02595	2.99e-173	-	-	-	K	ko:K19333	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02596	2.82e-260	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02598	5.2e-54	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
BIGIONGN_02599	5.85e-225	-	-	-	P	ko:K07217	-	ko00000	Catalase
BIGIONGN_02600	2.88e-217	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
BIGIONGN_02601	0.0	-	-	-	F	-	-	-	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
BIGIONGN_02602	8.86e-78	ydeP9	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGIONGN_02603	1.53e-211	-	-	-	S	ko:K06911	-	ko00000	Belongs to the pirin family
BIGIONGN_02604	3.83e-199	ycnC	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02605	8.19e-267	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
BIGIONGN_02606	8.16e-38	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02607	4.75e-96	-	-	-	-	-	-	-	-
BIGIONGN_02609	1.42e-47	-	-	-	-	-	-	-	-
BIGIONGN_02610	1.62e-140	-	-	-	S	-	-	-	Putative adhesin
BIGIONGN_02611	6.27e-155	-	-	-	S	-	-	-	ABC-2 family transporter protein
BIGIONGN_02612	3.21e-214	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_02613	1.76e-172	-	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_02614	7.73e-257	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02615	9.33e-195	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIGIONGN_02616	1.28e-166	-	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
BIGIONGN_02617	1.99e-260	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02618	1.68e-177	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
BIGIONGN_02619	0.0	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02620	0.0	sfuB	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02621	2.8e-255	fbpC	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
BIGIONGN_02622	6.74e-244	-	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_02624	6.2e-114	-	-	-	-	-	-	-	-
BIGIONGN_02625	1.21e-288	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
BIGIONGN_02626	1.26e-286	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
BIGIONGN_02627	5.04e-308	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
BIGIONGN_02628	2.98e-288	-	-	-	E	-	-	-	Peptidase family M28
BIGIONGN_02629	1.42e-247	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_02630	1.3e-236	-	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_02631	1.12e-214	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
BIGIONGN_02632	1.5e-202	appB	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_02633	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
BIGIONGN_02635	8.88e-213	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02636	1.93e-204	-	-	-	G	-	-	-	BadF/BadG/BcrA/BcrD ATPase family
BIGIONGN_02637	8.52e-269	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
BIGIONGN_02638	2.88e-69	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
BIGIONGN_02639	2.68e-67	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGIONGN_02640	5e-292	celD	2.7.1.207	-	G	ko:K02761,ko:K02787,ko:K02788	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGIONGN_02641	2.22e-61	-	-	-	-	-	-	-	-
BIGIONGN_02642	0.0	-	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
BIGIONGN_02643	2.15e-75	-	-	-	-	-	-	-	-
BIGIONGN_02644	3.93e-181	-	-	-	S	-	-	-	CAAX protease self-immunity
BIGIONGN_02645	2.28e-113	-	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
BIGIONGN_02646	0.0	-	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
BIGIONGN_02650	0.0	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_02653	7.65e-87	ytcD	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_02654	5.33e-133	-	1.6.5.2	-	S	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
BIGIONGN_02655	2e-143	-	-	-	K	-	-	-	intracellular protease amidase
BIGIONGN_02657	2.24e-31	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGIONGN_02659	1.32e-307	-	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIGIONGN_02660	9.43e-176	-	5.1.3.6	-	GM	ko:K08679	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Male sterility protein
BIGIONGN_02661	1.27e-174	epsN	-	-	E	ko:K19430	-	ko00000,ko01000	Belongs to the DegT DnrJ EryC1 family
BIGIONGN_02662	2.32e-13	epsM	-	-	GM	ko:K19429	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
BIGIONGN_02663	1.73e-88	rfbP	-	-	M	ko:K19428	-	ko00000,ko01000	Bacterial sugar transferase
BIGIONGN_02664	1.74e-134	-	-	-	M	-	-	-	COG0438 Glycosyltransferase
BIGIONGN_02665	7.11e-104	-	-	-	M	-	-	-	Glycosyl transferase 4-like
BIGIONGN_02667	1.56e-106	-	-	-	M	-	-	-	Glycosyl transferases group 1
BIGIONGN_02668	1.93e-22	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
BIGIONGN_02669	9.58e-105	-	-	-	S	-	-	-	Polysaccharide biosynthesis protein
BIGIONGN_02670	3.27e-302	pglF	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
BIGIONGN_02671	2.7e-201	-	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
BIGIONGN_02672	4.37e-193	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIGIONGN_02674	1.61e-254	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_02675	4.96e-270	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
BIGIONGN_02676	8.09e-241	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
BIGIONGN_02677	0.0	gerAA	-	-	EG	ko:K06288,ko:K06310	-	ko00000	Spore germination protein
BIGIONGN_02678	3.81e-253	-	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
BIGIONGN_02679	1.08e-133	-	-	-	K	ko:K16137	-	ko00000,ko03000	Bacterial regulatory proteins, tetR family
BIGIONGN_02680	2.05e-104	-	-	-	S	-	-	-	Bacterial PH domain
BIGIONGN_02681	1.23e-172	ycdF	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	Short-chain dehydrogenase reductase sdr
BIGIONGN_02682	0.0	yrbD	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
BIGIONGN_02683	1.83e-156	mdmC1	-	-	S	-	-	-	O-methyltransferase
BIGIONGN_02684	8.19e-213	-	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_02685	2.76e-59	sdpR	-	-	K	-	-	-	transcriptional
BIGIONGN_02686	1.15e-146	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
BIGIONGN_02687	8.13e-184	-	-	-	G	-	-	-	Phosphoenolpyruvate phosphomutase
BIGIONGN_02688	5.33e-207	-	-	-	E	-	-	-	Glyoxalase-like domain
BIGIONGN_02689	2.37e-236	-	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_02690	6.08e-177	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
BIGIONGN_02691	5.38e-167	ssuB	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
BIGIONGN_02693	2.43e-151	lin0465	-	-	S	-	-	-	DJ-1/PfpI family
BIGIONGN_02694	1.85e-199	-	-	-	K	ko:K13572	-	ko00000,ko03051	transcriptional regulator
BIGIONGN_02695	1.63e-195	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BIGIONGN_02696	4.05e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_02697	7.18e-186	-	-	-	S	-	-	-	Alpha/beta hydrolase family
BIGIONGN_02698	6.19e-239	-	-	-	GM	-	-	-	NAD dependent epimerase/dehydratase family
BIGIONGN_02700	0.0	tetM	-	-	J	ko:K18220	-	br01600,ko00000,ko01504	Elongation factor G, domain IV
BIGIONGN_02702	2.04e-294	-	-	-	S	-	-	-	Putative esterase
BIGIONGN_02703	4.71e-119	yvdQ	-	-	S	-	-	-	Protein of unknown function (DUF3231)
BIGIONGN_02704	3.03e-63	ycbP	-	-	S	-	-	-	Protein of unknown function (DUF2512)
BIGIONGN_02705	5.69e-183	yqjF	-	-	S	ko:K09166	-	ko00000	Uncharacterized conserved protein (COG2071)
BIGIONGN_02707	1.89e-276	-	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
BIGIONGN_02708	0.0	allB	3.5.2.5	-	F	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
BIGIONGN_02709	0.0	-	-	-	S	-	-	-	Membrane
BIGIONGN_02710	1.17e-77	pucM	3.5.2.17	-	S	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
BIGIONGN_02711	1.26e-235	-	1.7.3.3, 4.1.1.97	-	Q	ko:K16838	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
BIGIONGN_02712	1.16e-114	-	-	-	S	-	-	-	OHCU decarboxylase
BIGIONGN_02713	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
BIGIONGN_02714	1.34e-299	pucF	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
BIGIONGN_02715	3.62e-310	pucG	2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51	-	E	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	ko00000,ko00001,ko00002,ko01000,ko01007	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
BIGIONGN_02716	2.32e-121	-	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03518	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
BIGIONGN_02717	0.0	pucD	1.17.1.4	-	C	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
BIGIONGN_02718	5.76e-212	pucC	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03519	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
BIGIONGN_02719	9.99e-86	kapB	-	-	G	ko:K06347	ko02020,map02020	ko00000,ko00001	Kinase associated protein B
BIGIONGN_02720	3.24e-53	-	-	-	-	-	-	-	-
BIGIONGN_02721	2.85e-147	ypjP	-	-	S	-	-	-	YpjP-like protein
BIGIONGN_02722	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
BIGIONGN_02723	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase
BIGIONGN_02725	4.78e-198	telA	-	-	P	-	-	-	Belongs to the TelA family
BIGIONGN_02726	6.2e-215	-	-	-	-	-	-	-	-
BIGIONGN_02727	7.61e-247	-	-	-	S	-	-	-	Protein of unknown function (DUF2777)
BIGIONGN_02728	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Membrane
BIGIONGN_02729	4.28e-112	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
BIGIONGN_02730	5.49e-42	-	-	-	-	-	-	-	-
BIGIONGN_02731	2.15e-201	ypgR	-	-	C	-	-	-	COG0694 Thioredoxin-like proteins and domains
BIGIONGN_02732	1.7e-176	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
BIGIONGN_02733	1.03e-96	-	-	-	CO	-	-	-	Thioredoxin-like
BIGIONGN_02734	1.09e-100	yphP	-	-	S	-	-	-	Belongs to the UPF0403 family
BIGIONGN_02735	3.99e-74	yusE	-	-	CO	-	-	-	cell redox homeostasis
BIGIONGN_02736	9.28e-221	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
BIGIONGN_02737	1.13e-125	yraA	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
BIGIONGN_02738	3.7e-299	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIGIONGN_02739	2.9e-26	-	-	-	-	-	-	-	-
BIGIONGN_02740	2.53e-80	yppE	-	-	S	-	-	-	Bacterial domain of unknown function (DUF1798)
BIGIONGN_02741	4.53e-117	racA	-	-	K	ko:K11686	-	ko00000,ko03036	Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
BIGIONGN_02743	8.6e-220	yppC	-	-	S	-	-	-	Protein of unknown function (DUF2515)
BIGIONGN_02744	2.96e-151	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
BIGIONGN_02745	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
BIGIONGN_02746	0.0	ypbR	-	-	S	-	-	-	Dynamin family
BIGIONGN_02747	2.51e-158	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIGIONGN_02748	6.12e-166	dnaD	-	-	L	ko:K02086	-	ko00000	DNA replication protein DnaD
BIGIONGN_02749	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	asparaginyl-tRNA
BIGIONGN_02750	4.96e-108	ypmB	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_02751	8.74e-32	ypmA	-	-	S	-	-	-	Protein of unknown function (DUF4264)
BIGIONGN_02753	3.83e-316	mtaD	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
BIGIONGN_02754	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
BIGIONGN_02755	2.31e-229	-	-	-	S	-	-	-	Tetratricopeptide repeat
BIGIONGN_02756	8.4e-85	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIGIONGN_02757	1.67e-218	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIGIONGN_02758	2.4e-195	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
BIGIONGN_02759	1.1e-228	birA	6.3.4.15	-	K	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
BIGIONGN_02760	1.37e-268	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
BIGIONGN_02761	5.73e-256	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
BIGIONGN_02762	1.06e-166	bshB1	-	-	S	ko:K01463	-	ko00000,ko01000	proteins, LmbE homologs
BIGIONGN_02763	4.17e-37	-	-	-	-	-	-	-	-
BIGIONGN_02764	4.17e-194	-	-	-	S	-	-	-	Nucleotidyltransferase domain
BIGIONGN_02765	2.66e-215	ydhU	-	-	P	ko:K07217	-	ko00000	Catalase
BIGIONGN_02766	1.84e-246	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
BIGIONGN_02767	1.4e-147	-	-	-	S	-	-	-	CAAX protease self-immunity
BIGIONGN_02768	9.73e-165	-	-	-	K	ko:K11922	-	ko00000,ko03000	UTRA
BIGIONGN_02769	0.0	glvA	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
BIGIONGN_02770	2.14e-178	-	3.5.1.105	-	G	ko:K03478	-	ko00000,ko01000	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides
BIGIONGN_02771	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
BIGIONGN_02774	4.03e-23	-	-	-	-	-	-	-	-
BIGIONGN_02775	1.62e-36	-	-	-	-	-	-	-	-
BIGIONGN_02776	2.91e-94	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGIONGN_02778	1.8e-164	-	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
BIGIONGN_02779	0.0	-	4.3.2.2, 5.5.1.2	-	F	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminus
BIGIONGN_02780	0.0	-	2.7.1.199, 2.7.1.208	-	G	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_02781	9.45e-181	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
BIGIONGN_02782	7.09e-80	-	-	-	-	-	-	-	-
BIGIONGN_02783	5.44e-120	-	-	-	S	-	-	-	DinB superfamily
BIGIONGN_02786	8.01e-26	-	-	-	-	-	-	-	-
BIGIONGN_02787	0.0	tagE6	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGIONGN_02788	3.61e-77	-	-	-	-	-	-	-	-
BIGIONGN_02789	8.77e-135	-	-	-	-	-	-	-	-
BIGIONGN_02790	6.72e-161	-	-	-	-	-	-	-	-
BIGIONGN_02791	9.17e-70	padR	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02792	3.31e-30	-	-	-	UW	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
BIGIONGN_02793	4.67e-52	-	-	-	-	-	-	-	-
BIGIONGN_02795	1.02e-71	-	-	-	S	-	-	-	membrane
BIGIONGN_02797	9.99e-29	-	-	-	-	-	-	-	-
BIGIONGN_02799	2.26e-76	yqiX	-	-	S	-	-	-	YolD-like protein
BIGIONGN_02801	1.47e-88	-	-	-	L	-	-	-	Metallo-beta-lactamase superfamily
BIGIONGN_02804	3.86e-44	-	-	-	-	-	-	-	-
BIGIONGN_02805	1.26e-140	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
BIGIONGN_02806	1.43e-31	-	-	-	S	-	-	-	Bacteriophage A118-like holin, Hol118
BIGIONGN_02807	3.74e-36	xhlA	-	-	S	-	-	-	Haemolysin XhlA
BIGIONGN_02808	1.26e-47	-	-	-	-	-	-	-	-
BIGIONGN_02809	1.97e-109	-	-	-	-	-	-	-	-
BIGIONGN_02812	1.62e-70	-	-	-	-	-	-	-	-
BIGIONGN_02813	5e-26	-	-	-	-	-	-	-	-
BIGIONGN_02814	2.61e-85	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
BIGIONGN_02815	8.87e-144	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
BIGIONGN_02816	2.32e-52	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
BIGIONGN_02817	1.42e-19	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
BIGIONGN_02818	8.43e-152	xkdQ	-	-	G	-	-	-	NLP P60 protein
BIGIONGN_02819	3.08e-111	xkdP	-	-	S	-	-	-	Lysin motif
BIGIONGN_02820	8.66e-226	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
BIGIONGN_02821	1.29e-57	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
BIGIONGN_02822	2.43e-87	xkdM	-	-	S	-	-	-	Phage tail tube protein
BIGIONGN_02823	5.26e-233	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
BIGIONGN_02824	3.73e-13	-	-	-	-	-	-	-	-
BIGIONGN_02825	3.45e-38	xkdJ	-	-	-	-	-	-	-
BIGIONGN_02826	5.89e-74	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
BIGIONGN_02827	2.29e-21	yqbH	-	-	S	-	-	-	Domain of unknown function (DUF3599)
BIGIONGN_02828	1.58e-31	yqbG	-	-	S	-	-	-	Protein of unknown function (DUF3199)
BIGIONGN_02830	2.18e-166	xkdG	-	-	S	-	-	-	Phage capsid family
BIGIONGN_02831	2.87e-98	yqbD	-	-	L	-	-	-	Putative phage serine protease XkdF
BIGIONGN_02833	1.54e-82	-	-	-	S	-	-	-	Phage Mu protein F like protein
BIGIONGN_02834	1.34e-203	yqbA	-	-	S	-	-	-	portal protein
BIGIONGN_02835	2.12e-211	-	-	-	S	-	-	-	TIGRFAM Phage
BIGIONGN_02836	1.13e-15	-	-	-	L	ko:K07474	-	ko00000	Terminase small subunit
BIGIONGN_02840	1.04e-36	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
BIGIONGN_02843	6.25e-49	-	-	-	S	ko:K07741	-	ko00000	Phage regulatory protein Rha (Phage_pRha)
BIGIONGN_02848	4.42e-112	-	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
BIGIONGN_02850	2.95e-13	-	-	-	-	-	-	-	-
BIGIONGN_02851	8.11e-47	-	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
BIGIONGN_02854	7.35e-77	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
BIGIONGN_02858	6.64e-50	xkdB	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_02864	4.93e-80	-	-	-	-	-	-	-	-
BIGIONGN_02865	1.47e-21	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_02866	3.37e-27	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_02867	1.73e-17	-	-	-	-	-	-	-	-
BIGIONGN_02869	3.21e-68	-	-	-	E	-	-	-	IrrE N-terminal-like domain
BIGIONGN_02870	7.12e-36	-	-	-	-	-	-	-	-
BIGIONGN_02871	5.8e-130	-	-	-	S	-	-	-	recombinase activity
BIGIONGN_02872	4.37e-180	-	-	-	K	-	-	-	SIR2-like domain
BIGIONGN_02873	5.22e-225	-	-	-	S	-	-	-	membrane
BIGIONGN_02874	1.72e-305	ydbM	-	-	I	-	-	-	acyl-CoA dehydrogenase
BIGIONGN_02876	1.92e-92	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
BIGIONGN_02877	4.16e-149	mucD	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIGIONGN_02878	2.82e-80	yojF	-	-	S	-	-	-	Protein of unknown function (DUF1806)
BIGIONGN_02879	1.15e-160	bshB2	-	-	S	ko:K22135	-	ko00000,ko01000	deacetylase
BIGIONGN_02880	1.6e-216	-	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	Helix-hairpin-helix class 2 (Pol1 family) motifs
BIGIONGN_02881	1.3e-135	yokL3	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_02882	1.09e-118	yocC	-	-	-	-	-	-	-
BIGIONGN_02883	1.16e-76	ytxJ	-	-	O	-	-	-	Protein of unknown function (DUF2847)
BIGIONGN_02884	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGIONGN_02885	2.25e-202	yvgN	-	-	S	-	-	-	reductase
BIGIONGN_02886	0.0	ykpA	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
BIGIONGN_02887	9.15e-45	yozC	-	-	-	-	-	-	-
BIGIONGN_02888	2.1e-260	odhB	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
BIGIONGN_02889	0.0	odhA	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
BIGIONGN_02891	5.72e-263	-	-	-	Q	-	-	-	O-methyltransferase
BIGIONGN_02892	3.88e-153	-	-	-	M	ko:K21471,ko:K21472	-	ko00000,ko01000,ko01002,ko01011	lytic transglycosylase activity
BIGIONGN_02894	1.36e-100	ymaD	-	-	O	-	-	-	redox protein, regulator of disulfide bond formation
BIGIONGN_02895	0.0	-	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIGIONGN_02897	1.58e-221	sagG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
BIGIONGN_02898	3.22e-162	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_02899	3.25e-154	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_02900	1.98e-259	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_02901	1.24e-137	-	-	-	KT	ko:K02479	-	ko00000,ko02022	LuxR family transcriptional regulator
BIGIONGN_02903	1.13e-123	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIGIONGN_02904	1.51e-161	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
BIGIONGN_02905	1.39e-101	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
BIGIONGN_02906	8.12e-165	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BIGIONGN_02907	1.58e-302	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
BIGIONGN_02908	0.0	agcS	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
BIGIONGN_02909	1.95e-57	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
BIGIONGN_02910	5.71e-58	ywcE	-	-	S	-	-	-	Required for proper spore morphogenesis. Important for spore germination
BIGIONGN_02911	2.19e-67	qoxD	1.10.3.12	-	C	ko:K02829	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
BIGIONGN_02912	4.91e-144	qoxC	1.10.3.12	-	C	ko:K02828	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
BIGIONGN_02913	0.0	qoxB	1.10.3.12	-	C	ko:K02827	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIGIONGN_02914	7.16e-236	qoxA	1.10.3.12	-	C	ko:K02826	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
BIGIONGN_02915	3.94e-58	-	-	-	S	-	-	-	DNA alkylation repair protein
BIGIONGN_02916	5.48e-281	-	-	-	I	ko:K01066	-	ko00000,ko01000	COG0657 Esterase lipase
BIGIONGN_02917	2.57e-127	msrA	1.8.4.11	-	O	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIGIONGN_02918	3.64e-70	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
BIGIONGN_02920	7.84e-207	cheV	-	-	T	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	Chemotaxis protein CheV
BIGIONGN_02921	1.18e-225	-	3.4.13.19	-	E	ko:K01273	-	ko00000,ko00537,ko01000,ko01002,ko04147	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog
BIGIONGN_02922	6.63e-95	hspX	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
BIGIONGN_02923	1.03e-47	-	-	-	S	-	-	-	YppG-like protein
BIGIONGN_02924	1.28e-31	-	-	-	-	-	-	-	-
BIGIONGN_02925	3.02e-298	ykuI	-	-	T	-	-	-	Diguanylate phosphodiesterase
BIGIONGN_02926	3.44e-200	-	-	-	I	-	-	-	Hydrolase
BIGIONGN_02927	2.03e-230	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BIGIONGN_02928	4.11e-105	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
BIGIONGN_02929	2.52e-198	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
BIGIONGN_02930	1.02e-98	yneP	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
BIGIONGN_02931	0.0	spoVK_1	-	-	O	-	-	-	stage V sporulation protein K
BIGIONGN_02932	2.94e-183	-	-	-	P	ko:K07245	-	ko00000,ko02000	Copper resistance protein D
BIGIONGN_02933	3.93e-17	sspN	-	-	S	ko:K06431	-	ko00000	Small acid-soluble spore protein N family
BIGIONGN_02934	2.3e-06	-	-	-	S	-	-	-	Fur-regulated basic protein B
BIGIONGN_02935	0.0	citB	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIGIONGN_02937	3.83e-19	-	-	-	-	-	-	-	-
BIGIONGN_02938	2.93e-107	yneK	-	-	S	-	-	-	Protein of unknown function (DUF2621)
BIGIONGN_02939	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_02940	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_02941	8.21e-39	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
BIGIONGN_02942	5.64e-97	yneE	-	-	S	-	-	-	Sporulation inhibitor of replication protein sirA
BIGIONGN_02943	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIGIONGN_02944	2.51e-46	ynzC	-	-	S	-	-	-	UPF0291 protein
BIGIONGN_02945	8.37e-153	yneB	-	-	L	-	-	-	resolvase
BIGIONGN_02947	8.11e-145	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIGIONGN_02948	4.36e-283	yuxJ	-	-	EGP	-	-	-	Major facilitator superfamily
BIGIONGN_02950	2.2e-273	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIGIONGN_02951	2.14e-127	-	-	-	FG	-	-	-	Domain of unknown function (DUF4269)
BIGIONGN_02952	8.41e-119	-	-	-	-	-	-	-	-
BIGIONGN_02953	2.49e-177	-	-	-	K	-	-	-	helix_turn_helix isocitrate lyase regulation
BIGIONGN_02954	4.49e-183	-	-	-	Q	-	-	-	Domain of unknown function (DUF2437)
BIGIONGN_02955	0.0	glcB	2.3.3.9	-	C	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BIGIONGN_02956	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
BIGIONGN_02957	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
BIGIONGN_02958	0.0	-	-	-	C	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	FAD binding domain
BIGIONGN_02959	5.69e-100	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_02960	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
BIGIONGN_02961	1.24e-314	ynbB	-	-	P	-	-	-	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
BIGIONGN_02962	2.02e-220	spoVK	-	-	O	ko:K06413	-	ko00000	stage V sporulation protein K
BIGIONGN_02963	3.91e-245	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
BIGIONGN_02964	1.24e-47	hfq	-	-	J	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	ko00000,ko00001,ko03019,ko03036	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
BIGIONGN_02965	8.29e-223	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIGIONGN_02966	3.18e-67	-	-	-	J	-	-	-	Putative SAM-dependent methyltransferase
BIGIONGN_02967	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIGIONGN_02968	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIGIONGN_02969	1.13e-133	cotE	-	-	S	ko:K06328	-	ko00000	Spore coat protein
BIGIONGN_02970	3.16e-88	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
BIGIONGN_02971	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIGIONGN_02972	7.83e-200	tgl	2.3.2.13	-	H	ko:K00686	-	ko00000,ko01000	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
BIGIONGN_02973	7.82e-51	spoVS	-	-	S	ko:K06416	-	ko00000	Stage V sporulation protein S
BIGIONGN_02974	8.12e-196	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
BIGIONGN_02975	3.81e-293	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
BIGIONGN_02976	7.7e-149	-	-	-	L	-	-	-	DNA recombination
BIGIONGN_02977	1.02e-10	-	-	-	-	-	-	-	-
BIGIONGN_02978	0.0	-	-	-	L	-	-	-	AAA domain
BIGIONGN_02979	1.41e-240	-	-	-	L	-	-	-	Calcineurin-like phosphoesterase superfamily domain
BIGIONGN_02980	1.47e-243	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BIGIONGN_02981	0.0	deaD	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
BIGIONGN_02982	7.13e-294	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
BIGIONGN_02983	2.85e-128	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIGIONGN_02984	1.58e-188	ymfM	-	-	S	ko:K15539	-	ko00000	protein conserved in bacteria
BIGIONGN_02985	5.43e-180	ymfK	-	-	S	-	-	-	Protein of unknown function (DUF3388)
BIGIONGN_02986	3.99e-53	ymfJ	-	-	S	-	-	-	Protein of unknown function (DUF3243)
BIGIONGN_02987	1.22e-158	ymfI	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_02988	0.0	ymfH	-	-	S	-	-	-	zinc protease
BIGIONGN_02989	6.72e-303	albE	-	-	S	-	-	-	Peptidase M16
BIGIONGN_02990	2.49e-167	ymfC	-	-	K	ko:K03710	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_02991	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
BIGIONGN_02992	3.72e-06	-	-	-	S	-	-	-	YlzJ-like protein
BIGIONGN_02993	3.79e-165	tepA	-	-	OU	-	-	-	COG0740 Protease subunit of ATP-dependent Clp proteases
BIGIONGN_02994	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIGIONGN_02995	1.26e-210	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIGIONGN_02996	1.52e-282	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
BIGIONGN_02997	8.86e-245	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIGIONGN_02998	9.26e-139	spoVFB	-	-	H	ko:K06411	-	ko00000	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
BIGIONGN_02999	3.31e-205	spoVFA	-	-	E	ko:K06410	-	ko00000	subunit a
BIGIONGN_03000	5.31e-49	ymxH	-	-	S	-	-	-	YlmC YmxH family
BIGIONGN_03001	1.81e-290	mlpA	-	-	S	-	-	-	Belongs to the peptidase M16 family
BIGIONGN_03002	1.36e-244	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
BIGIONGN_03003	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
BIGIONGN_03004	7.11e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIGIONGN_03005	6.07e-226	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
BIGIONGN_03006	6.31e-223	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIGIONGN_03007	2.49e-75	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIGIONGN_03008	5.12e-56	ylxP	-	-	S	ko:K09764	-	ko00000	protein conserved in bacteria
BIGIONGN_03009	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIGIONGN_03010	2.49e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
BIGIONGN_03011	1.42e-57	ylxR	-	-	K	ko:K07742	-	ko00000	nucleic-acid-binding protein implicated in transcription termination
BIGIONGN_03012	3.99e-257	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
BIGIONGN_03013	3.83e-104	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
BIGIONGN_03014	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIGIONGN_03015	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
BIGIONGN_03016	3.42e-297	rasP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
BIGIONGN_03017	4.74e-266	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
BIGIONGN_03018	7.6e-176	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
BIGIONGN_03019	2.61e-188	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIGIONGN_03020	1.86e-116	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
BIGIONGN_03021	1.18e-160	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
BIGIONGN_03022	5.04e-200	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIGIONGN_03023	5.65e-171	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
BIGIONGN_03025	7.05e-171	sigD	-	-	K	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_03026	7.7e-110	cheD	3.5.1.44	-	NT	ko:K03411	ko02030,map02030	ko00000,ko00001,ko01000,ko02035	Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
BIGIONGN_03027	3.87e-141	cheC	-	-	NT	ko:K03410	ko02030,map02030	ko00000,ko00001,ko02035	COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
BIGIONGN_03028	3.12e-222	cheB	3.1.1.61, 3.5.1.44	-	NT	ko:K03412	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
BIGIONGN_03029	4.39e-127	-	-	-	-	-	-	-	-
BIGIONGN_03030	3.28e-232	flhF	-	-	N	ko:K02404	-	ko00000,ko02035	Flagellar biosynthesis regulator FlhF
BIGIONGN_03031	0.0	flhA	-	-	N	ko:K02400	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIGIONGN_03032	1.3e-243	flhB	-	-	N	ko:K02401	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIGIONGN_03033	1.12e-170	fliR	-	-	N	ko:K02421	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthetic protein FliR
BIGIONGN_03034	8.01e-54	fliQ	-	-	N	ko:K02420	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Role in flagellar biosynthesis
BIGIONGN_03035	1.04e-145	fliP	-	-	N	ko:K02419	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Plays a role in the flagellum-specific transport system
BIGIONGN_03036	1.48e-136	fliZ	-	-	N	ko:K02418	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthesis protein, FliO
BIGIONGN_03037	2.57e-78	cheY	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
BIGIONGN_03038	2.38e-272	fliY	-	-	N	ko:K02417	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035,ko02044	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIGIONGN_03039	1.13e-225	fliM	-	-	N	ko:K02416	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
BIGIONGN_03040	1.61e-92	fliL	-	-	N	ko:K02415	-	ko00000,ko02035	Controls the rotational direction of flagella during chemotaxis
BIGIONGN_03041	3.86e-38	flbD	-	-	N	ko:K02385	-	ko00000,ko02035	protein, possibly involved in motility
BIGIONGN_03042	6.89e-189	flgG	-	-	N	ko:K02390	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod
BIGIONGN_03043	4.43e-95	flgD	-	-	N	ko:K02389	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod modification protein
BIGIONGN_03044	0.0	-	-	-	N	ko:K02414	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-length control protein FliK
BIGIONGN_03046	2.64e-93	fliJ	-	-	N	ko:K02413	ko02040,map02040	ko00000,ko00001,ko02035	bacterial-type flagellum organization
BIGIONGN_03047	1.19e-312	fliI	3.6.3.14	-	NU	ko:K02412	ko02040,map02040	ko00000,ko00001,ko01000,ko02035,ko02044	COG1157 Flagellar biosynthesis type III secretory pathway ATPase
BIGIONGN_03048	6.63e-110	fliH	-	-	NU	ko:K02411	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	COG1317 Flagellar biosynthesis type III secretory pathway protein
BIGIONGN_03049	1.32e-227	fliG	-	-	N	ko:K02410	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
BIGIONGN_03050	0.0	fliF	-	-	N	ko:K02409	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	The M ring may be actively involved in energy transduction
BIGIONGN_03051	8.2e-58	fliE	-	-	N	ko:K02408	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-basal body
BIGIONGN_03052	6.48e-99	flgC	-	-	N	ko:K02388	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the flagella basal body rod proteins family
BIGIONGN_03053	2.47e-88	flgB	-	-	N	ko:K02387	ko02040,map02040	ko00000,ko00001,ko02035	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
BIGIONGN_03054	2.27e-174	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIGIONGN_03055	7.5e-301	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BIGIONGN_03056	1.05e-120	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIGIONGN_03057	7.91e-216	xerC	-	-	L	ko:K03733,ko:K04763	-	ko00000,ko03036	tyrosine recombinase XerC
BIGIONGN_03058	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BIGIONGN_03059	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIGIONGN_03060	5.65e-212	dprA	-	-	LU	ko:K04096	-	ko00000	Rossmann fold nucleotide-binding protein involved in DNA uptake
BIGIONGN_03061	3.09e-215	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BIGIONGN_03062	1.27e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
BIGIONGN_03063	5.58e-104	ylqH	-	-	S	ko:K04061	-	ko00000,ko02044	FlhB HrpN YscU SpaS Family
BIGIONGN_03065	1.6e-176	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIGIONGN_03066	7.25e-206	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIGIONGN_03067	2.9e-133	sipS	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
BIGIONGN_03068	1.9e-11	-	-	-	-	-	-	-	-
BIGIONGN_03069	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
BIGIONGN_03070	0.0	-	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl tRNA synthetase N terminal dom
BIGIONGN_03071	1.76e-175	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
BIGIONGN_03072	6.52e-124	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIGIONGN_03073	2.5e-90	-	-	-	S	-	-	-	YlqD protein
BIGIONGN_03074	1.11e-45	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
BIGIONGN_03075	7.93e-59	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
BIGIONGN_03076	5.06e-314	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIGIONGN_03077	3.83e-68	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIGIONGN_03078	3.38e-226	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
BIGIONGN_03079	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
BIGIONGN_03080	2.38e-14	yfkK	-	-	S	-	-	-	Belongs to the UPF0435 family
BIGIONGN_03081	1.55e-177	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
BIGIONGN_03082	1.35e-42	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIGIONGN_03083	1.04e-164	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
BIGIONGN_03084	9.23e-219	fabD	2.3.1.39	-	I	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	malonyl CoA-acyl carrier protein transacylase
BIGIONGN_03085	3.16e-232	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
BIGIONGN_03086	1.53e-127	fapR	-	-	K	-	-	-	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
BIGIONGN_03087	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIGIONGN_03088	1.55e-195	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
BIGIONGN_03089	2.23e-157	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
BIGIONGN_03090	1.68e-194	yitS	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_03091	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
BIGIONGN_03092	1.81e-78	yloU	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_03093	4.09e-35	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
BIGIONGN_03095	7.77e-151	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
BIGIONGN_03096	7.3e-213	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
BIGIONGN_03097	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
BIGIONGN_03098	1.7e-168	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
BIGIONGN_03099	1.86e-316	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIGIONGN_03100	1.48e-217	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIGIONGN_03101	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIGIONGN_03102	1.19e-277	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIGIONGN_03103	5.59e-41	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
BIGIONGN_03104	3.88e-144	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
BIGIONGN_03105	1.15e-52	ylzA	-	-	S	ko:K09777	-	ko00000	Belongs to the UPF0296 family
BIGIONGN_03106	0.0	yloB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
BIGIONGN_03107	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
BIGIONGN_03108	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
BIGIONGN_03110	2.31e-156	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
BIGIONGN_03111	7.28e-142	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIGIONGN_03112	5.62e-165	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
BIGIONGN_03113	1.79e-214	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
BIGIONGN_03114	5.05e-187	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
BIGIONGN_03115	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarB family
BIGIONGN_03116	2.97e-269	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
BIGIONGN_03117	1.68e-313	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
BIGIONGN_03118	1.59e-211	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
BIGIONGN_03119	7.11e-293	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Xanthine uracil
BIGIONGN_03120	2.85e-135	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIGIONGN_03121	2.2e-223	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
BIGIONGN_03122	8.13e-99	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIGIONGN_03123	9.51e-148	yteA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
BIGIONGN_03124	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIGIONGN_03125	2.64e-96	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
BIGIONGN_03126	7.72e-179	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
BIGIONGN_03127	7.03e-58	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	membrane
BIGIONGN_03128	2.04e-94	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
BIGIONGN_03129	3.51e-154	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIGIONGN_03130	6.52e-190	ylmD	-	-	S	ko:K05810	-	ko00000,ko01000	Belongs to the multicopper oxidase YfiH RL5 family
BIGIONGN_03131	6.23e-62	ylmC	-	-	S	-	-	-	sporulation protein
BIGIONGN_03132	3.67e-181	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_03133	8.95e-161	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIGIONGN_03134	3.73e-208	spoIIGA	-	-	M	ko:K06383	-	ko00000,ko01000,ko01002	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
BIGIONGN_03135	4.15e-241	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIGIONGN_03136	1.19e-294	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
BIGIONGN_03138	1.27e-173	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
BIGIONGN_03139	5.14e-247	spoVE	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
BIGIONGN_03140	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIGIONGN_03141	9.92e-218	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIGIONGN_03142	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
BIGIONGN_03143	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIGIONGN_03144	0.0	spoVD	-	-	M	ko:K08384	ko00550,map00550	ko00000,ko00001,ko01011	stage V sporulation protein D
BIGIONGN_03146	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
BIGIONGN_03147	2.26e-62	ftsL	-	-	D	-	-	-	cell division protein FtsL
BIGIONGN_03148	9.29e-222	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
BIGIONGN_03149	4.81e-103	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
BIGIONGN_03150	0.0	bshC	-	-	S	ko:K22136	-	ko00000	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BIGIONGN_03152	5.93e-204	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIGIONGN_03153	2.19e-121	ylbP	-	-	K	-	-	-	n-acetyltransferase
BIGIONGN_03154	2.21e-102	ylbO	-	-	S	ko:K06314	-	ko00000,ko03000	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
BIGIONGN_03155	7.12e-36	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
BIGIONGN_03156	2.84e-120	ylbN	-	-	S	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
BIGIONGN_03157	1.32e-292	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
BIGIONGN_03158	4.78e-249	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
BIGIONGN_03159	2.03e-178	ylbK	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
BIGIONGN_03160	3.72e-281	ylbJ	-	-	S	-	-	-	Sporulation integral membrane protein YlbJ
BIGIONGN_03161	1.28e-108	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIGIONGN_03162	8.32e-128	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
BIGIONGN_03163	3.58e-85	-	-	-	S	-	-	-	Methylthioribose kinase
BIGIONGN_03164	4.89e-63	ylbG	-	-	S	-	-	-	UPF0298 protein
BIGIONGN_03165	4.07e-92	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
BIGIONGN_03166	9.06e-184	-	-	-	HJ	ko:K05844	-	ko00000,ko01000,ko03009	Prokaryotic glutathione synthetase, ATP-grasp domain
BIGIONGN_03167	7.5e-43	ylbE	-	-	S	-	-	-	YlbE-like protein
BIGIONGN_03168	5.03e-95	ylbD	-	-	S	-	-	-	Putative coat protein
BIGIONGN_03169	2.89e-110	-	-	-	Q	ko:K02614	ko00360,map00360	ko00000,ko00001,ko01000	protein, possibly involved in aromatic compounds catabolism
BIGIONGN_03170	8.94e-272	ylbC	-	-	S	-	-	-	protein with SCP PR1 domains
BIGIONGN_03171	1.34e-83	ylbA	-	-	S	-	-	-	YugN-like family
BIGIONGN_03172	1.67e-110	-	-	-	-	-	-	-	-
BIGIONGN_03173	1.13e-120	yozB	-	-	S	ko:K08976	-	ko00000	membrane
BIGIONGN_03174	7.24e-69	ctaF	1.9.3.1	-	C	ko:K02277	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
BIGIONGN_03175	8.77e-144	ctaE	1.9.3.1	-	C	ko:K02276	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
BIGIONGN_03176	0.0	ctaD	1.9.3.1	-	C	ko:K02274	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIGIONGN_03177	2.38e-253	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
BIGIONGN_03178	6.42e-205	ctaA	-	-	O	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	ko00000,ko00001,ko00002,ko03029	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
BIGIONGN_03180	3.91e-128	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
BIGIONGN_03181	7.5e-76	-	-	-	-	-	-	-	-
BIGIONGN_03187	2.17e-06	-	-	-	S	-	-	-	Protein of unknown function (DUF4065)
BIGIONGN_03191	1.72e-20	-	-	-	S	-	-	-	Protein of unknown function (DUF1064)
BIGIONGN_03200	1.03e-100	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	D,D-heptose 1,7-bisphosphate phosphatase
BIGIONGN_03203	1.13e-23	-	-	-	-	-	-	-	-
BIGIONGN_03218	6.24e-63	-	-	-	S	-	-	-	Cell division protein FtsJ
BIGIONGN_03219	1.91e-48	-	-	-	-	-	-	-	-
BIGIONGN_03224	6.61e-38	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_03226	7.4e-08	-	-	-	-	-	-	-	-
BIGIONGN_03227	9.26e-27	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_03229	9.03e-45	-	-	-	-	-	-	-	-
BIGIONGN_03249	1.65e-129	-	-	-	S	-	-	-	ATP-dependent DNA helicase activity
BIGIONGN_03251	1.24e-217	-	-	-	L	-	-	-	Helix-hairpin-helix containing domain
BIGIONGN_03252	5.63e-94	-	-	-	S	-	-	-	FtsK/SpoIIIE family
BIGIONGN_03256	2.57e-18	-	-	-	M	-	-	-	peptidase M23
BIGIONGN_03258	7.01e-49	-	-	-	D	-	-	-	Tubulin/FtsZ family, GTPase domain
BIGIONGN_03261	0.000626	sigL	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
BIGIONGN_03263	2.45e-17	hupB	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
BIGIONGN_03268	8.69e-150	ylaK	-	-	T	ko:K07175	-	ko00000	PIN domain
BIGIONGN_03270	9.84e-136	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase superfamily domain
BIGIONGN_03277	4.34e-194	-	-	-	S	-	-	-	Terminase-like family
BIGIONGN_03289	6.65e-37	-	-	-	N	-	-	-	Bacterial Ig-like domain 2
BIGIONGN_03291	2.46e-12	-	-	-	-	-	-	-	-
BIGIONGN_03292	2.03e-105	-	-	-	S	-	-	-	Phage integrase family
BIGIONGN_03294	1.32e-20	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_03297	9.86e-21	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
BIGIONGN_03300	1.04e-217	-	-	-	S	-	-	-	peptidoglycan catabolic process
BIGIONGN_03302	1.84e-142	-	-	-	S	-	-	-	Pfam Transposase IS66
BIGIONGN_03303	5.23e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF1617)
BIGIONGN_03305	8.03e-235	-	-	-	M	-	-	-	Pectate lyase superfamily protein
BIGIONGN_03308	2.96e-12	-	-	-	G	-	-	-	cellulose 1,4-beta-cellobiosidase activity
BIGIONGN_03312	1e-84	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
BIGIONGN_03315	0.0	tagE6	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
BIGIONGN_03316	6.29e-30	-	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
BIGIONGN_03323	0.000626	-	-	-	O	-	-	-	PFAM SPFH domain Band 7 family
BIGIONGN_03326	1.41e-29	-	-	-	S	-	-	-	Siphovirus Gp157
BIGIONGN_03333	1.94e-26	-	2.7.7.7, 3.6.4.12	-	L	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIGIONGN_03334	2.47e-121	ligB	6.5.1.1, 6.5.1.6, 6.5.1.7	-	L	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	ko00000,ko00001,ko01000,ko03032,ko03400	ATP-dependent DNA ligase
BIGIONGN_03335	3.03e-56	-	-	-	S	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphoribosyl-ATP pyrophosphohydrolase
BIGIONGN_03337	3.41e-177	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGIONGN_03338	2.66e-82	-	-	-	-	-	-	-	-
BIGIONGN_03343	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGIONGN_03344	2.46e-25	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
BIGIONGN_03345	7.13e-05	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
BIGIONGN_03348	1.66e-17	-	-	-	K	-	-	-	transcriptional
BIGIONGN_03349	2.09e-28	-	-	-	L	-	-	-	NAD-dependent DNA ligase adenylation domain
BIGIONGN_03357	1.08e-19	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
BIGIONGN_03359	8.76e-109	-	-	-	L	-	-	-	Belongs to the N(4) N(6)-methyltransferase family
BIGIONGN_03364	8.95e-57	-	-	-	S	-	-	-	Peptidyl-tRNA hydrolase PTH2
BIGIONGN_03370	3.9e-144	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
BIGIONGN_03381	5.89e-14	-	-	-	S	-	-	-	HicB family
BIGIONGN_03382	1.09e-48	-	-	-	S	-	-	-	Protein of unknown function (DUF2493)
BIGIONGN_03384	1.95e-07	-	-	-	-	-	-	-	-
BIGIONGN_03394	4.12e-18	-	-	-	-	-	-	-	-
BIGIONGN_03397	2.94e-32	-	-	-	-	-	-	-	-
BIGIONGN_03399	3.36e-66	-	-	-	-	-	-	-	-
BIGIONGN_03403	3.38e-110	-	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
BIGIONGN_03406	5.54e-33	-	-	-	S	-	-	-	kinase activity
BIGIONGN_03418	1.53e-159	-	-	-	S	-	-	-	C-5 cytosine-specific DNA methylase
BIGIONGN_03421	9.31e-14	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIGIONGN_03422	8.77e-110	-	-	-	L	-	-	-	Domain of unknown function (DUF4942)
BIGIONGN_03423	5e-21	-	-	-	S	-	-	-	Hypothetical protein (DUF2513)
BIGIONGN_03424	2.5e-121	-	-	-	S	-	-	-	Thymidylate synthase
BIGIONGN_03425	4.3e-55	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	COG2131 Deoxycytidylate deaminase
BIGIONGN_03427	4.62e-30	-	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_03428	2.46e-271	-	-	-	S	-	-	-	Bacterial DNA polymerase III alpha subunit
BIGIONGN_03429	8.71e-307	-	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
BIGIONGN_03430	1.98e-182	-	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
BIGIONGN_03431	1.84e-71	-	-	-	L	-	-	-	DNA primase activity
BIGIONGN_03432	7.83e-117	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
BIGIONGN_03433	3.13e-28	-	-	-	-	-	-	-	-
BIGIONGN_03434	5.4e-131	-	-	-	L	-	-	-	AAA domain
BIGIONGN_03435	1.59e-78	-	-	-	-	-	-	-	-
BIGIONGN_03436	9.06e-23	-	-	-	-	-	-	-	-
BIGIONGN_03437	9.57e-91	-	-	-	O	ko:K18481,ko:K18640	-	ko00000,ko00002,ko02000,ko04812	unfolded protein binding
BIGIONGN_03439	2.61e-53	-	-	-	L	-	-	-	Initiator Replication protein
BIGIONGN_03442	2.31e-60	yqiX	-	-	S	-	-	-	YolD-like protein
BIGIONGN_03443	1.02e-09	-	-	-	L	-	-	-	Helix-turn-helix domain
BIGIONGN_03444	8.78e-07	-	-	-	L	-	-	-	HNH endonuclease
BIGIONGN_03452	1.69e-69	-	-	-	V	ko:K07448	-	ko00000,ko02048	Restriction endonuclease
BIGIONGN_03455	1.33e-135	-	-	-	UW	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
BIGIONGN_03457	6.29e-75	serS3	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGIONGN_03458	5.07e-06	serS3	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGIONGN_03459	3.29e-170	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_03460	4.63e-142	-	-	-	L	-	-	-	DNA alkylation repair enzyme
BIGIONGN_03462	2.24e-102	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGIONGN_03463	1.45e-186	-	-	-	S	-	-	-	Alpha beta hydrolase
BIGIONGN_03464	6.36e-98	yfiK	-	-	K	-	-	-	Regulator
BIGIONGN_03465	1.17e-94	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_03466	3.85e-143	sagG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_03467	6.08e-107	sagH	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_03468	2.81e-117	sagI	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-type multidrug transport system, permease component
BIGIONGN_03469	9.23e-111	-	-	-	S	-	-	-	Chlorophyllase
BIGIONGN_03470	1.68e-132	-	-	-	S	-	-	-	Chlorophyllase
BIGIONGN_03472	7.32e-51	-	-	-	K	-	-	-	Helix-turn-helix domain
BIGIONGN_03473	0.000136	pepF1_3	-	-	E	-	-	-	oligoendopeptidase F
BIGIONGN_03474	3.12e-145	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_03475	1.67e-167	-	-	-	GM	-	-	-	NmrA-like family
BIGIONGN_03476	2.79e-07	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	Domain of unknown function (DUF4162)
BIGIONGN_03477	5.47e-140	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	Domain of unknown function (DUF4162)
BIGIONGN_03478	4.53e-147	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_03479	1.01e-218	tnpA1	-	-	L	-	-	-	Transposase
BIGIONGN_03480	1.54e-172	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_03481	1.8e-307	serS3	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGIONGN_03482	1.14e-167	-	-	-	L	-	-	-	DNA alkylation repair enzyme
BIGIONGN_03483	7.92e-76	-	-	-	S	-	-	-	AAA domain
BIGIONGN_03484	2.15e-127	-	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Phosphoglycerate mutase family
BIGIONGN_03485	3.77e-250	-	-	-	T	-	-	-	Signal transduction histidine kinase
BIGIONGN_03486	4.49e-143	-	-	-	KT	-	-	-	LuxR family transcriptional regulator
BIGIONGN_03487	1.54e-218	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
BIGIONGN_03488	1.55e-290	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGIONGN_03489	1.36e-246	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_03490	8.79e-200	gspA	-	-	M	-	-	-	Glycosyl transferase family 8
BIGIONGN_03491	1.34e-91	yxjI	-	-	S	-	-	-	LURP-one-related
BIGIONGN_03492	9.42e-225	adcA	-	-	P	ko:K09815,ko:K09818	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
BIGIONGN_03493	1.56e-169	-	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
BIGIONGN_03494	2.51e-130	p20	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_03495	2.2e-62	-	-	-	-	-	-	-	-
BIGIONGN_03496	2.33e-136	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
BIGIONGN_03497	0.0	-	-	-	P	ko:K06901	-	ko00000,ko02000	secondary active sulfate transmembrane transporter activity
BIGIONGN_03498	0.0	yfkN	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01081,ko:K06931,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
BIGIONGN_03499	8.39e-75	-	-	-	S	-	-	-	Regulatory protein YrvL
BIGIONGN_03500	1.16e-243	yccF	-	-	K	ko:K07039	-	ko00000	SEC-C motif
BIGIONGN_03501	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Sodium:sulfate symporter transmembrane region
BIGIONGN_03502	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIGIONGN_03503	0.0	cstA	-	-	T	ko:K06200	-	ko00000	Carbon starvation protein
BIGIONGN_03504	2.45e-124	-	-	-	-	-	-	-	-
BIGIONGN_03505	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_03506	1.25e-137	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIGIONGN_03507	1.89e-63	-	-	-	H	-	-	-	3-demethylubiquinone-9 3-O-methyltransferase activity
BIGIONGN_03508	1.01e-127	adc	4.1.1.4	-	Q	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide
BIGIONGN_03510	2.64e-268	pamO	-	-	P	ko:K07222	-	ko00000	Flavin-binding monooxygenase-like
BIGIONGN_03511	0.0	scrA5	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_03512	0.0	bglC1	3.2.1.21, 3.2.1.52	GH3	G	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
BIGIONGN_03513	0.0	sacA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
BIGIONGN_03514	3.15e-195	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_03515	1.36e-121	-	-	-	S	-	-	-	MepB protein
BIGIONGN_03516	2.75e-215	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_03517	3.91e-167	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGIONGN_03518	1.55e-81	yhcF	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_03519	3.38e-158	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGIONGN_03520	1.74e-168	-	-	-	-	-	-	-	-
BIGIONGN_03521	3.25e-251	yhfE	-	-	G	-	-	-	peptidase M42
BIGIONGN_03522	6.41e-106	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
BIGIONGN_03523	9.34e-130	yhzB	-	-	S	-	-	-	B3/4 domain
BIGIONGN_03524	6.67e-284	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BIGIONGN_03525	9.84e-123	ogt	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIGIONGN_03526	4.7e-108	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_03527	1.66e-215	yhbB	-	-	S	-	-	-	Putative amidase domain
BIGIONGN_03528	1.24e-114	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
BIGIONGN_03529	3.08e-115	yufK	-	-	S	-	-	-	Family of unknown function (DUF5366)
BIGIONGN_03530	2.76e-70	-	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
BIGIONGN_03531	0.0	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
BIGIONGN_03532	0.0	prkA	-	-	T	ko:K07180	-	ko00000	Ser protein kinase
BIGIONGN_03533	3.64e-134	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
BIGIONGN_03534	1.69e-179	cysA1	-	-	S	-	-	-	AAA domain
BIGIONGN_03535	1.11e-281	yhbH	-	-	S	ko:K09786	-	ko00000	Belongs to the UPF0229 family
BIGIONGN_03537	1.07e-213	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_03538	0.0	-	-	-	EGP	-	-	-	the major facilitator superfamily
BIGIONGN_03539	1.6e-224	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
BIGIONGN_03540	3.14e-191	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
BIGIONGN_03541	1.97e-111	-	-	-	S	-	-	-	Protein of unknown function (DUF664)
BIGIONGN_03542	0.0	-	-	-	G	ko:K10297	-	ko00000,ko04121	Right handed beta helix region
BIGIONGN_03543	3.19e-205	ydaD	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_03544	0.0	-	-	-	E	ko:K03307	-	ko00000	Sodium:solute symporter family
BIGIONGN_03545	3.83e-165	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
BIGIONGN_03546	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
BIGIONGN_03547	1.33e-168	yvoA	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
BIGIONGN_03548	2.95e-284	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIGIONGN_03549	6.62e-177	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
BIGIONGN_03550	1.34e-168	-	1.5.1.39	-	C	ko:K10678,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	ko00000,ko00001,ko01000	Oxidoreductase
BIGIONGN_03551	9.52e-287	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
BIGIONGN_03552	8.12e-151	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
BIGIONGN_03553	2.31e-175	yqiK	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
BIGIONGN_03554	1.02e-93	-	-	-	-	-	-	-	-
BIGIONGN_03556	0.0	yhcX	-	-	K	-	-	-	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
BIGIONGN_03557	7.42e-162	sfsA	-	-	S	ko:K06206	-	ko00000	Sugar fermentation stimulation protein
BIGIONGN_03558	0.0	-	1.1.5.3	-	C	ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
BIGIONGN_03559	0.0	pgcA	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
BIGIONGN_03560	0.0	spoVR	-	-	S	ko:K06415	-	ko00000	Stage V sporulation protein R
BIGIONGN_03561	0.0	yknU	-	-	V	ko:K06147,ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_03562	0.0	yknV	-	-	V	ko:K02021,ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_03563	2.59e-295	avtA	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
BIGIONGN_03564	4.1e-193	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Peptidase family M48
BIGIONGN_03565	3.52e-124	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
BIGIONGN_03566	1.97e-275	yngJ	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
BIGIONGN_03567	0.0	yngH	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase
BIGIONGN_03568	1.95e-41	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin carboxyl carrier protein
BIGIONGN_03569	4.36e-174	yngF	-	-	I	-	-	-	Belongs to the enoyl-CoA hydratase isomerase family
BIGIONGN_03570	0.0	yngE	-	-	I	-	-	-	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
BIGIONGN_03572	1.76e-277	-	-	-	-	-	-	-	-
BIGIONGN_03573	1.78e-102	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70, region 4
BIGIONGN_03574	8.44e-262	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_03575	2.85e-207	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
BIGIONGN_03576	2.94e-31	-	-	-	-	-	-	-	-
BIGIONGN_03578	8.19e-267	yheB	-	-	S	-	-	-	Belongs to the UPF0754 family
BIGIONGN_03579	2.8e-72	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
BIGIONGN_03580	1.44e-201	yhaX	-	-	S	-	-	-	hydrolases of the HAD superfamily
BIGIONGN_03582	1.47e-66	-	-	-	-	-	-	-	-
BIGIONGN_03583	2.31e-162	cssR	-	-	T	ko:K07770	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_03584	0.0	cssS	2.7.13.3	-	T	ko:K07650	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_03585	4.85e-231	yhaM	-	-	L	ko:K03698	-	ko00000,ko01000,ko03019	Shows a 3'-5' exoribonuclease activity
BIGIONGN_03586	6.88e-59	yhaL	-	-	S	-	-	-	Sporulation protein YhaL
BIGIONGN_03587	2.1e-213	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
BIGIONGN_03588	2.48e-06	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
BIGIONGN_03589	1.99e-139	-	-	-	S	-	-	-	Protein conserved in bacteria
BIGIONGN_03590	2.03e-141	hpr	-	-	K	ko:K09682	-	ko00000,ko03000	Negative regulator of protease production and sporulation
BIGIONGN_03591	1.39e-72	yhaH	-	-	D	-	-	-	gas vesicle protein
BIGIONGN_03592	3.09e-268	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIGIONGN_03593	1.56e-98	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
BIGIONGN_03594	8.06e-177	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	transporter (ATP-binding protein)
BIGIONGN_03595	2.55e-287	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_03596	6.61e-167	ecsC	-	-	S	-	-	-	EcsC protein family
BIGIONGN_03597	1.59e-156	ccdA	-	-	O	ko:K06196	-	ko00000,ko02000	cytochrome c biogenesis protein
BIGIONGN_03598	0.0	pbpF	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
BIGIONGN_03599	5.06e-260	hemE	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BIGIONGN_03600	2.93e-233	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
BIGIONGN_03601	0.0	hemY	1.3.3.15, 1.3.3.4	-	H	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIGIONGN_03603	4.46e-132	spo0B	-	-	T	ko:K06375	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01000	Sporulation initiation phospho-transferase B, C-terminal
BIGIONGN_03604	7.15e-295	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIGIONGN_03605	3.91e-95	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
BIGIONGN_03606	9.54e-208	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
BIGIONGN_03607	2.02e-117	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
BIGIONGN_03608	1.21e-264	nifS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
BIGIONGN_03609	0.0	nadB	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
BIGIONGN_03610	5.03e-194	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NadC ModD family
BIGIONGN_03611	1.79e-267	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BIGIONGN_03612	1.35e-270	safA	-	-	M	ko:K06370	-	ko00000	spore coat assembly protein SafA
BIGIONGN_03613	7.43e-25	-	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
BIGIONGN_03614	1.36e-84	-	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	cytochrome c oxidase subunit II
BIGIONGN_03615	8.79e-120	bofC	-	-	S	ko:K06318	-	ko00000	BofC C-terminal domain
BIGIONGN_03616	1.41e-136	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
BIGIONGN_03617	2.23e-234	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
BIGIONGN_03618	7.27e-38	yrzS	-	-	S	-	-	-	Protein of unknown function (DUF2905)
BIGIONGN_03619	4.07e-246	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIGIONGN_03620	6.48e-291	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
BIGIONGN_03621	1.92e-51	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit YajC
BIGIONGN_03622	2.94e-80	yrzE	-	-	S	-	-	-	Protein of unknown function (DUF3792)
BIGIONGN_03623	1.1e-102	-	-	-	S	-	-	-	membrane
BIGIONGN_03624	4.87e-216	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03625	1.06e-109	-	-	-	-	-	-	-	-
BIGIONGN_03626	8.78e-121	-	-	-	-	-	-	-	-
BIGIONGN_03627	3.85e-66	-	-	-	-	-	-	-	-
BIGIONGN_03628	5.52e-93	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03629	1.92e-29	-	-	-	-	-	-	-	-
BIGIONGN_03630	1.59e-82	-	-	-	U	-	-	-	domain, Protein
BIGIONGN_03631	6.08e-106	-	-	-	-	-	-	-	-
BIGIONGN_03632	6.17e-112	-	-	-	-	-	-	-	-
BIGIONGN_03633	6.18e-67	-	-	-	-	-	-	-	-
BIGIONGN_03634	3.19e-94	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03635	2.31e-104	-	-	-	-	-	-	-	-
BIGIONGN_03636	5.55e-90	-	-	-	S	ko:K21494	-	ko00000,ko02048	SMI1 / KNR4 family
BIGIONGN_03637	5.96e-54	-	-	-	-	-	-	-	-
BIGIONGN_03638	1.64e-73	-	-	-	-	-	-	-	-
BIGIONGN_03639	4.54e-70	-	-	-	-	-	-	-	-
BIGIONGN_03643	2.13e-124	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
BIGIONGN_03644	7.21e-281	gbuA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
BIGIONGN_03645	1.38e-189	gbuB	-	-	P	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
BIGIONGN_03646	1.26e-217	opuAC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
BIGIONGN_03648	2.3e-256	cfr	2.1.1.224	-	J	ko:K15632	-	ko00000,ko01000,ko01504,ko03009	Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics
BIGIONGN_03649	0.0	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
BIGIONGN_03650	1.55e-66	yerC	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_03651	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIGIONGN_03652	0.0	acyII	3.5.1.11	-	S	ko:K01434	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000,ko01002	Penicillin amidase
BIGIONGN_03653	2.27e-216	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
BIGIONGN_03654	5.02e-33	mepA	-	-	V	-	-	-	MATE efflux family protein
BIGIONGN_03656	2.97e-227	fhuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_03657	6.43e-220	fhuG	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIGIONGN_03658	1.02e-194	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
BIGIONGN_03659	3.89e-166	pcrB	-	-	I	ko:K07094	-	ko00000,ko01000	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BIGIONGN_03660	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
BIGIONGN_03661	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIGIONGN_03662	8.79e-285	camS	-	-	S	-	-	-	COG4851 Protein involved in sex pheromone biosynthesis
BIGIONGN_03663	2.24e-261	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
BIGIONGN_03664	0.0	yufO	3.6.3.17	-	S	ko:K02056	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_03665	1.3e-242	yufP	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGIONGN_03666	2.6e-209	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGIONGN_03668	4.31e-231	-	-	-	-	-	-	-	-
BIGIONGN_03669	5.2e-118	yizA	-	-	S	-	-	-	DinB family
BIGIONGN_03670	3.39e-60	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIGIONGN_03671	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
BIGIONGN_03672	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIGIONGN_03673	1.43e-219	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
BIGIONGN_03674	1.2e-105	ykuN	-	-	C	ko:K03839	-	ko00000	Flavodoxin
BIGIONGN_03675	0.0	rlmCD	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIGIONGN_03676	6.88e-129	-	-	-	-	-	-	-	-
BIGIONGN_03677	0.0	-	2.7.1.194	-	GKT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	COG3711 Transcriptional antiterminator
BIGIONGN_03678	8.46e-58	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
BIGIONGN_03679	2.22e-284	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
BIGIONGN_03680	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIGIONGN_03681	8.34e-179	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_03682	6.55e-42	-	-	-	K	-	-	-	MerR family transcriptional regulator
BIGIONGN_03683	1.13e-315	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
BIGIONGN_03684	0.0	-	4.2.1.82	-	EG	ko:K22396	ko00040,map00040	ko00000,ko00001,ko01000	Dehydratase family
BIGIONGN_03685	1.23e-182	-	-	-	K	ko:K19333	-	ko00000,ko03000	helix_turn_helix isocitrate lyase regulation
BIGIONGN_03686	3.75e-209	-	4.2.1.141	-	S	ko:K14259	ko00040,map00040	ko00000,ko00001,ko01000	Fumarylacetoacetate (FAA) hydrolase family
BIGIONGN_03687	1.21e-213	-	4.1.2.28, 4.3.3.7	-	EM	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
BIGIONGN_03688	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_03689	5.45e-169	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
BIGIONGN_03690	4.67e-171	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
BIGIONGN_03691	0.0	psaA3	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Zinc-uptake complex component A periplasmic
BIGIONGN_03692	1.73e-247	zinT	-	-	S	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
BIGIONGN_03693	6.98e-89	yjiA	-	-	S	-	-	-	Cobalamin biosynthesis protein CobW
BIGIONGN_03694	9.47e-100	yjiA	-	-	S	-	-	-	Cobalamin biosynthesis protein CobW
BIGIONGN_03696	8.2e-209	-	-	-	S	-	-	-	Alpha beta hydrolase
BIGIONGN_03697	9.86e-177	ygaJ	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
BIGIONGN_03698	2.36e-213	-	-	-	Q	-	-	-	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
BIGIONGN_03699	7.58e-210	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_03700	9.3e-249	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
BIGIONGN_03701	3.88e-118	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
BIGIONGN_03702	3.33e-272	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
BIGIONGN_03703	1.37e-64	-	4.2.1.7	-	G	ko:K16849	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	SAF
BIGIONGN_03704	1.76e-277	-	4.2.1.7	-	G	ko:K16850	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	D-galactarate dehydratase / Altronate hydrolase, C terminus
BIGIONGN_03705	0.0	M1-1044	-	-	S	-	-	-	Belongs to the UPF0061 (SELO) family
BIGIONGN_03706	2.54e-243	nagC_1	-	-	GK	-	-	-	ROK family
BIGIONGN_03707	2.13e-259	glcP1	-	-	G	ko:K08174	-	ko00000,ko02000	Major Facilitator Superfamily
BIGIONGN_03708	0.0	yicI	3.2.1.177	GH31	G	ko:K01811	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 31 family
BIGIONGN_03709	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_03710	0.0	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
BIGIONGN_03711	3.82e-229	-	-	-	P	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03712	2.76e-218	lplC1	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03713	0.0	lplA3	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_03714	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
BIGIONGN_03715	8.66e-169	ytbQ	1.1.1.203, 1.1.1.388	-	GM	ko:K18981,ko:K19243	ko00030,ko00053,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00053,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	NAD dependent epimerase/dehydratase family
BIGIONGN_03716	1.11e-138	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_03717	6.88e-259	-	4.2.2.2	-	M	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectic acid lyase
BIGIONGN_03718	1.46e-207	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_03719	0.0	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_03720	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_03721	1.19e-231	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
BIGIONGN_03722	1.63e-199	ytcP3	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03723	6.53e-220	-	-	-	E	-	-	-	Abhydrolase family
BIGIONGN_03724	0.0	-	3.2.1.37, 3.2.1.55	GH43,GH51	G	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
BIGIONGN_03725	1.28e-279	yteR	3.2.1.172	GH105	G	ko:K15532	-	ko00000,ko01000	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
BIGIONGN_03726	5.75e-103	-	-	-	G	-	-	-	carbohydrate transport
BIGIONGN_03727	4.26e-158	yteU	-	-	S	-	-	-	Integral membrane protein
BIGIONGN_03728	0.0	yteT	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
BIGIONGN_03729	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
BIGIONGN_03730	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
BIGIONGN_03731	6.62e-222	-	-	-	K	-	-	-	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
BIGIONGN_03732	1.72e-99	srlR	-	-	K	-	-	-	Glucitol operon activator
BIGIONGN_03733	3.77e-127	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
BIGIONGN_03734	4.5e-234	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol sorbitol-specific transporter subunit IIB
BIGIONGN_03735	1.44e-74	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
BIGIONGN_03736	2.05e-182	-	1.1.1.140	-	C	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_03737	2.01e-203	-	-	AA10,CBM73	D	ko:K03933	-	ko00000	Lytic polysaccharide mono-oxygenase, cellulose-degrading
BIGIONGN_03738	8.68e-44	-	-	-	S	-	-	-	Sporulation inhibitor A
BIGIONGN_03739	5.39e-130	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
BIGIONGN_03740	0.0	-	-	-	M	-	-	-	Domain of unknown function DUF11
BIGIONGN_03741	2.49e-295	-	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
BIGIONGN_03742	2.62e-217	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
BIGIONGN_03743	3.44e-300	hisD	1.1.1.23, 1.1.1.308	-	E	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIGIONGN_03744	3.97e-161	ycbL	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
BIGIONGN_03745	2.23e-212	ycbM	-	-	T	-	-	-	Histidine kinase
BIGIONGN_03746	3.75e-214	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_03747	2.73e-149	-	-	-	S	-	-	-	ABC-2 family transporter protein
BIGIONGN_03748	5.31e-149	ydfE	-	-	S	-	-	-	Flavin reductase like domain
BIGIONGN_03749	2.59e-160	ydfF	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
BIGIONGN_03750	3.57e-209	-	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
BIGIONGN_03751	1.91e-258	-	-	-	T	-	-	-	Histidine kinase
BIGIONGN_03752	1.06e-166	yrkP	-	-	T	ko:K02483	-	ko00000,ko02022	Transcriptional regulator
BIGIONGN_03753	8.12e-240	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Arginase family
BIGIONGN_03754	1.02e-146	-	-	-	S	-	-	-	HTH domain
BIGIONGN_03755	5.29e-268	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
BIGIONGN_03756	2.25e-217	eutB	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
BIGIONGN_03757	3.46e-214	-	4.3.1.12	-	E	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	ko00000,ko00001,ko01000	Ornithine cyclodeaminase/mu-crystallin family
BIGIONGN_03758	3.42e-06	-	-	-	S	-	-	-	Sporulation inhibitor A
BIGIONGN_03759	9.09e-149	yhcQ	-	-	M	-	-	-	Spore coat protein
BIGIONGN_03760	7.1e-309	ycgH	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
BIGIONGN_03761	5.44e-139	ycgF	-	-	E	-	-	-	Lysine exporter protein LysE YggA
BIGIONGN_03762	5.34e-88	yjqC	-	-	P	ko:K07217	-	ko00000	Catalase
BIGIONGN_03763	1.87e-76	ygzB	-	-	S	-	-	-	UPF0295 protein
BIGIONGN_03764	1.18e-103	perR	-	-	P	ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
BIGIONGN_03765	6.47e-64	-	-	-	S	-	-	-	Cyclic-di-AMP receptor
BIGIONGN_03766	7.75e-231	ghrA	-	-	EH	-	-	-	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGIONGN_03767	4.85e-116	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Peroxiredoxin
BIGIONGN_03768	5.04e-314	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
BIGIONGN_03769	2.34e-242	ygaE	-	-	S	-	-	-	Membrane
BIGIONGN_03770	0.0	ygaD	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
BIGIONGN_03771	2.94e-133	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
BIGIONGN_03772	6.03e-23	-	-	-	S	ko:K06422	-	ko00000	Small, acid-soluble spore protein, gamma-type
BIGIONGN_03773	9.29e-169	fabL	1.3.1.104	-	IQ	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_03774	5.62e-27	yfhS	-	-	-	-	-	-	-
BIGIONGN_03775	3.86e-78	-	-	-	-	-	-	-	-
BIGIONGN_03776	2.28e-169	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_03777	9.61e-267	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific
BIGIONGN_03778	2.17e-242	yfhP	-	-	S	ko:K07038	-	ko00000	membrane-bound metal-dependent
BIGIONGN_03780	9.25e-30	-	-	-	S	-	-	-	YpzG-like protein
BIGIONGN_03781	1.58e-70	yfhH	-	-	S	-	-	-	Protein of unknown function (DUF1811)
BIGIONGN_03782	2.03e-184	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
BIGIONGN_03783	1.43e-218	yfhF	-	-	S	ko:K07071	-	ko00000	nucleoside-diphosphate sugar epimerase
BIGIONGN_03784	4.73e-66	-	-	-	-	-	-	-	-
BIGIONGN_03785	1.51e-263	mccF	-	-	V	-	-	-	LD-carboxypeptidase
BIGIONGN_03786	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIGIONGN_03787	2.29e-81	-	-	-	-	-	-	-	-
BIGIONGN_03789	1.23e-170	-	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
BIGIONGN_03790	2.82e-236	-	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03791	7.62e-175	-	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_03792	4.2e-146	surE	3.1.3.5	-	S	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Survival protein SurE
BIGIONGN_03793	4.6e-107	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
BIGIONGN_03794	2.06e-93	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_03795	1.16e-207	-	-	-	O	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
BIGIONGN_03797	2.14e-188	pdaA	-	-	G	ko:K01567	-	ko00000,ko01000	deacetylase
BIGIONGN_03798	1.86e-180	-	-	-	S	ko:K08974	-	ko00000	Domain of unknown function (DUF368)
BIGIONGN_03799	0.0	-	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
BIGIONGN_03800	1.2e-154	-	-	-	G	ko:K15640	-	ko00000	Belongs to the phosphoglycerate mutase family
BIGIONGN_03801	1.68e-279	yfkA	-	-	S	-	-	-	YfkB-like domain
BIGIONGN_03802	4.85e-189	yfkD	-	-	S	-	-	-	YfkD-like protein
BIGIONGN_03805	1.21e-29	-	-	-	S	-	-	-	Fur-regulated basic protein B
BIGIONGN_03806	2.4e-313	ythA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
BIGIONGN_03807	5.11e-242	ythB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
BIGIONGN_03808	4.13e-185	-	-	-	-	-	-	-	-
BIGIONGN_03809	0.0	pepF2	-	-	E	-	-	-	COG1164 Oligoendopeptidase F
BIGIONGN_03810	0.0	kat	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
BIGIONGN_03812	4.43e-58	-	-	-	L	-	-	-	Transposase IS200 like
BIGIONGN_03813	0.0	-	1.14.13.59	-	Q	ko:K03897	ko00310,ko01120,map00310,map01120	ko00000,ko00001,ko01000	L-lysine 6-monooxygenase (NADPH-requiring)
BIGIONGN_03814	0.0	ywdH	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
BIGIONGN_03815	4.23e-147	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Caulimovirus viroplasmin
BIGIONGN_03816	1.81e-54	-	-	-	-	-	-	-	-
BIGIONGN_03817	2.17e-62	-	-	-	K	-	-	-	SpoVT / AbrB like domain
BIGIONGN_03818	4.19e-75	-	-	-	-	-	-	-	-
BIGIONGN_03819	3.95e-308	yhdH	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
BIGIONGN_03820	3.04e-233	mreBH	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod-share determining protein MreBH
BIGIONGN_03821	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
BIGIONGN_03822	1.35e-210	pfkB	2.7.1.56	-	G	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
BIGIONGN_03823	2.57e-173	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_03824	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
BIGIONGN_03825	3.48e-269	nos	1.14.14.47	-	C	ko:K00491	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BIGIONGN_03826	9.32e-112	bsaA	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
BIGIONGN_03827	5.63e-164	treR	-	-	K	ko:K03486	-	ko00000,ko03000	transcriptional
BIGIONGN_03828	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
BIGIONGN_03829	0.0	treP	2.7.1.201	-	G	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_03830	0.0	ggt	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
BIGIONGN_03831	0.0	yngK	-	-	T	-	-	-	Glycosyl hydrolase-like 10
BIGIONGN_03832	1.21e-301	ykvU	-	-	S	-	-	-	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
BIGIONGN_03833	1.91e-314	alsT	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
BIGIONGN_03834	2.04e-122	glpP	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIGIONGN_03835	0.0	glpD	1.1.5.3	-	C	ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BIGIONGN_03836	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIGIONGN_03837	2.52e-298	kinB3	2.7.13.3	-	T	ko:K07697	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_03838	0.0	yfiC3	-	-	V	ko:K06147	-	ko00000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_03839	0.0	yfiB3	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
BIGIONGN_03840	0.0	uvrD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
BIGIONGN_03841	1.8e-218	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter
BIGIONGN_03842	3.79e-181	phnC	3.6.3.28	-	P	ko:K02041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BIGIONGN_03843	1.22e-175	phnE	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_03844	3.66e-184	ptxC	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_03845	5.86e-185	-	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIGIONGN_03846	3.55e-313	-	-	-	V	-	-	-	MatE
BIGIONGN_03847	2.01e-139	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_03848	2.64e-208	pepI	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Alpha/beta hydrolase family
BIGIONGN_03849	4.88e-207	dppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_03850	3.99e-233	dppB	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_03851	0.0	hbpA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_03852	2e-241	appF	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_03853	5.69e-235	dppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_03854	0.0	XK27_11280	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
BIGIONGN_03855	2.87e-84	-	-	-	S	-	-	-	Domain of unknown function (DUF4440)
BIGIONGN_03856	1.29e-132	ynaD	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_03857	1.28e-293	-	-	-	S	ko:K07112	-	ko00000	Sulphur transport
BIGIONGN_03858	8.97e-227	-	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	transport system, periplasmic component
BIGIONGN_03859	1.2e-219	-	-	-	S	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
BIGIONGN_03860	1.74e-181	-	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	transport system, ATPase component
BIGIONGN_03861	2.69e-248	-	-	-	-	-	-	-	-
BIGIONGN_03862	2.8e-256	cysA	3.6.3.25	-	P	ko:K02045	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BIGIONGN_03863	2.72e-172	cysW	-	-	P	ko:K02047	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG4208 ABC-type sulfate transport system, permease component
BIGIONGN_03864	7.52e-176	cysT	-	-	O	ko:K02046	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0555 ABC-type sulfate transport system, permease component
BIGIONGN_03865	1.61e-251	sbp	-	-	P	ko:K02048	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG1613 ABC-type sulfate transport system, periplasmic component
BIGIONGN_03866	1.62e-106	ebsC	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIGIONGN_03867	0.0	-	-	-	T	-	-	-	COG0642 Signal transduction histidine kinase
BIGIONGN_03868	0.0	dld	1.1.2.4, 1.1.3.15	-	C	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
BIGIONGN_03869	1.05e-206	yocS	-	-	S	ko:K03453	-	ko00000	-transporter
BIGIONGN_03870	0.0	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
BIGIONGN_03871	2.25e-207	-	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_03872	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_03873	1.64e-266	ytpB	4.2.3.130	-	S	ko:K16188	-	ko00000,ko01000	Tetraprenyl-beta-curcumene synthase
BIGIONGN_03874	9.94e-90	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
BIGIONGN_03875	2.5e-126	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_03876	2.34e-194	malG	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03877	2.72e-222	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03878	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_03879	0.0	-	-	-	S	ko:K09955	-	ko00000	Beta-L-arabinofuranosidase, GH127
BIGIONGN_03880	2.21e-221	yisR1	3.2.1.23	-	K	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	AraC-like ligand binding domain
BIGIONGN_03881	9.35e-161	spaF	-	-	V	ko:K01990,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_03882	6.53e-170	spaE	-	-	S	ko:K20491	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
BIGIONGN_03883	5.84e-174	spaG	-	-	S	ko:K20492	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
BIGIONGN_03884	4.88e-161	spaR	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
BIGIONGN_03885	0.0	spaK	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
BIGIONGN_03886	5.67e-96	-	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIGIONGN_03887	1.05e-97	lrpC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	helix_turn_helix ASNC type
BIGIONGN_03888	3.23e-133	argO	-	-	S	ko:K06895	-	ko00000,ko02000	Lysine exporter protein LysE YggA
BIGIONGN_03889	0.0	-	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
BIGIONGN_03890	1.03e-122	ykkA	-	-	S	-	-	-	Protein of unknown function (DUF664)
BIGIONGN_03891	7.45e-101	yuxK	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_03892	2.17e-111	-	-	-	S	-	-	-	Protein of unknown function (DUF1569)
BIGIONGN_03893	5.37e-74	-	-	-	-	-	-	-	-
BIGIONGN_03894	1.92e-26	-	-	-	S	ko:K21493	-	ko00000,ko01000,ko02048	Belongs to the WXG100 family
BIGIONGN_03895	6.23e-106	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03896	3.55e-79	-	-	-	-	-	-	-	-
BIGIONGN_03897	7.11e-181	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03898	4.85e-77	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
BIGIONGN_03900	3.94e-142	-	-	-	S	-	-	-	LXG domain of WXG superfamily
BIGIONGN_03902	8.89e-156	sapB	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
BIGIONGN_03903	2.93e-85	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIGIONGN_03904	1.93e-77	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIGIONGN_03905	1.28e-274	-	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
BIGIONGN_03908	4.71e-239	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BIGIONGN_03909	1.15e-109	ydiB	-	-	S	ko:K06925	-	ko00000,ko03016	ATPase or kinase
BIGIONGN_03910	1.44e-167	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214 Inactive homolog of metal-dependent proteases
BIGIONGN_03911	2.21e-114	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
BIGIONGN_03912	2.49e-232	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIGIONGN_03913	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
BIGIONGN_03914	6.15e-146	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIGIONGN_03915	7.3e-34	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
BIGIONGN_03916	2.86e-179	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIGIONGN_03917	2.61e-237	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIGIONGN_03918	3.92e-143	metP_2	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
BIGIONGN_03919	1.57e-194	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1464 ABC-type metal ion transport system, periplasmic component surface antigen
BIGIONGN_03920	1.64e-263	gldA	-	-	C	ko:K08317	-	ko00000,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
BIGIONGN_03922	1.16e-153	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
BIGIONGN_03923	7.46e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIGIONGN_03924	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
BIGIONGN_03925	0.0	-	-	-	G	-	-	-	Mga helix-turn-helix domain
BIGIONGN_03926	2.88e-96	-	2.7.1.194	-	GT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
BIGIONGN_03927	5.5e-56	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
BIGIONGN_03928	3.06e-283	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
BIGIONGN_03929	3.13e-170	-	-	-	S	-	-	-	carbohydrate derivative metabolic process
BIGIONGN_03930	1.75e-158	ypdP	-	-	S	ko:K09125	-	ko00000	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BIGIONGN_03931	2.72e-195	-	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
BIGIONGN_03932	0.0	yoaI	1.14.14.9	-	Q	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	ko00000,ko00001,ko01000	COG2368 Aromatic ring hydroxylase
BIGIONGN_03933	6.01e-115	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
BIGIONGN_03934	6.79e-135	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
BIGIONGN_03935	1.37e-109	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
BIGIONGN_03936	1.52e-239	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIGIONGN_03937	2.77e-308	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	molybdopterin
BIGIONGN_03938	5.32e-121	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
BIGIONGN_03939	2.79e-97	moaE	2.8.1.12	-	H	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	COG0314 Molybdopterin converting factor, large subunit
BIGIONGN_03940	1.73e-48	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BIGIONGN_03941	4.38e-183	nirC	-	-	P	ko:K02598	-	ko00000,ko02000	Formate/nitrite transporter
BIGIONGN_03942	0.0	yjgC	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase (NAD+) activity
BIGIONGN_03943	7.47e-141	yjgD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
BIGIONGN_03944	8.12e-193	fdhD	-	-	C	ko:K02379	-	ko00000	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BIGIONGN_03945	5.31e-115	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BIGIONGN_03946	4.31e-11	-	-	-	-	-	-	-	-
BIGIONGN_03947	6.31e-11	-	-	-	-	-	-	-	-
BIGIONGN_03948	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
BIGIONGN_03949	1.77e-91	-	-	-	S	-	-	-	GtrA-like protein
BIGIONGN_03950	2.7e-232	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
BIGIONGN_03951	1.89e-197	-	-	-	S	ko:K07025	-	ko00000	Haloacid dehalogenase-like hydrolase
BIGIONGN_03952	1.8e-185	-	-	-	-	-	-	-	-
BIGIONGN_03953	1.33e-191	tcyA_1	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
BIGIONGN_03954	3.11e-145	-	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03955	3.26e-153	-	-	-	E	ko:K02029,ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_03956	2.81e-191	-	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
BIGIONGN_03957	1.06e-96	-	-	-	M	-	-	-	ArpU family transcriptional regulator
BIGIONGN_03958	0.0	malK	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
BIGIONGN_03959	1.67e-160	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
BIGIONGN_03960	1.34e-312	malP	-	-	C	ko:K11616	ko02020,map02020	ko00000,ko00001	COG3493 Na citrate symporter
BIGIONGN_03961	4.48e-273	-	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
BIGIONGN_03962	4.93e-125	-	-	-	S	-	-	-	Short C-terminal domain
BIGIONGN_03963	1.05e-92	-	-	-	-	-	-	-	-
BIGIONGN_03964	6.77e-100	-	-	-	-	-	-	-	-
BIGIONGN_03965	1.82e-215	-	-	-	D	-	-	-	Phage tail tape measure protein, TP901 family
BIGIONGN_03966	8.4e-176	-	-	-	S	-	-	-	Phage tail protein
BIGIONGN_03967	0.0	-	-	-	L	-	-	-	Phage minor structural protein
BIGIONGN_03969	2.31e-100	-	-	-	S	-	-	-	Bacteriophage holin family
BIGIONGN_03970	6.48e-152	cwlC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
BIGIONGN_03971	1.6e-138	yfhC	-	-	C	-	-	-	nitroreductase
BIGIONGN_03972	0.0	pbpC	3.4.16.4	-	M	ko:K02545,ko:K21467	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	Penicillin-binding Protein
BIGIONGN_03973	1.15e-12	-	-	-	-	-	-	-	-
BIGIONGN_03975	1.07e-236	yvnB	-	-	Q	-	-	-	Calcineurin-like phosphoesterase
BIGIONGN_03976	3.01e-131	-	-	-	CO	-	-	-	Thioredoxin
BIGIONGN_03977	1.87e-221	yeaC	-	-	S	ko:K03924	-	ko00000,ko01000	COG0714 MoxR-like ATPases
BIGIONGN_03978	3.15e-277	yeaD	-	-	S	-	-	-	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
BIGIONGN_03979	0.0	yebA	-	-	E	-	-	-	COG1305 Transglutaminase-like enzymes
BIGIONGN_03980	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
BIGIONGN_03981	1.01e-100	-	-	-	S	-	-	-	glyoxalase bleomycin resistance protein dioxygenase
BIGIONGN_03983	1.4e-314	-	-	-	C	-	-	-	Na+/H+ antiporter family
BIGIONGN_03984	8.48e-241	dapB	1.4.1.12, 1.4.1.26	-	S	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	ko00000,ko00001,ko01000	Dihydrodipicolinate reductase, N-terminus
BIGIONGN_03985	3.35e-218	-	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_03986	1.92e-44	-	-	-	S	ko:K06880	-	ko00000,ko01000,ko01504	Erythromycin esterase
BIGIONGN_03988	5.08e-67	-	-	-	E	-	-	-	lactoylglutathione lyase activity
BIGIONGN_03989	5.96e-88	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGIONGN_03990	1.34e-85	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
BIGIONGN_03991	8.3e-117	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_03992	4.64e-151	XK27_07680	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
BIGIONGN_03993	3.4e-235	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
BIGIONGN_03994	0.0	-	2.7.1.194	-	GKT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	COG3711 Transcriptional antiterminator
BIGIONGN_03995	2.17e-57	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
BIGIONGN_03996	3.16e-296	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
BIGIONGN_03997	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIGIONGN_03998	4.18e-263	yvmA	-	-	EGP	-	-	-	Major Facilitator Superfamily
BIGIONGN_03999	3.85e-98	rmaD	-	-	K	-	-	-	Iron dependent repressor, N-terminal DNA binding domain
BIGIONGN_04000	5.43e-112	M1-431	-	-	S	-	-	-	Protein of unknown function (DUF1706)
BIGIONGN_04001	5e-227	dhaK	2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15	-	G	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	ko00000,ko00001,ko00002,ko01000	Dihydroxyacetone kinase DhaK, subunit
BIGIONGN_04002	4.71e-142	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
BIGIONGN_04003	7.13e-87	-	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
BIGIONGN_04004	1.45e-33	-	-	-	S	-	-	-	YfhD-like protein
BIGIONGN_04005	5.25e-279	-	-	-	G	-	-	-	Transmembrane secretion effector
BIGIONGN_04006	6.13e-232	-	-	-	S	-	-	-	Phosphotransferase enzyme family
BIGIONGN_04007	3.99e-92	-	-	-	-	-	-	-	-
BIGIONGN_04008	5.11e-286	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
BIGIONGN_04010	0.0	-	-	-	S	-	-	-	proteins of the AP superfamily
BIGIONGN_04011	2.96e-111	yhcN	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
BIGIONGN_04012	1.36e-191	ykoQ	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
BIGIONGN_04013	2.19e-220	-	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
BIGIONGN_04014	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
BIGIONGN_04015	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
BIGIONGN_04017	0.0	-	3.1.3.5, 3.6.1.45	-	F	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
BIGIONGN_04018	4.52e-37	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_04019	4.68e-99	ygaO	-	-	-	-	-	-	-
BIGIONGN_04020	1.28e-132	-	-	-	Q	-	-	-	Isochorismatase family
BIGIONGN_04021	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Molecular chaperone. Has ATPase activity
BIGIONGN_04022	0.0	abgT_2	-	-	H	ko:K12942	-	ko00000	AbgT putative transporter family
BIGIONGN_04023	1.74e-291	cypA	-	-	C	ko:K15468	-	ko00000,ko01008	Cytochrome P450
BIGIONGN_04024	2.91e-27	-	-	-	-	-	-	-	-
BIGIONGN_04025	0.0	-	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
BIGIONGN_04026	2.93e-176	lutA	-	-	C	ko:K18928	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
BIGIONGN_04027	0.0	lutB	-	-	C	ko:K18929	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
BIGIONGN_04028	3.55e-163	lutC	-	-	S	ko:K00782	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
BIGIONGN_04029	1.36e-177	yvfI	-	-	K	ko:K05799	-	ko00000,ko03000	COG2186 Transcriptional regulators
BIGIONGN_04030	7.06e-291	gbsB	1.1.1.1	-	C	ko:K11440	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
BIGIONGN_04031	0.0	gbsA	1.2.1.8	-	C	ko:K00130	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
BIGIONGN_04032	2.19e-130	-	-	-	K	ko:K22109	-	ko00000,ko03000	Belongs to the GbsR family
BIGIONGN_04033	2.83e-200	-	-	-	E	ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Substrate binding domain of ABC-type glycine betaine transport system
BIGIONGN_04034	2.3e-53	-	-	-	-	-	-	-	-
BIGIONGN_04035	1.04e-110	ltrC	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phosphatidylglycerophosphatase A
BIGIONGN_04038	1.26e-10	tlp	-	-	S	ko:K06434	-	ko00000	spore protein
BIGIONGN_04039	7.56e-209	-	-	-	K	-	-	-	LysR substrate binding domain
BIGIONGN_04040	1.05e-135	ywqN_1	-	-	S	-	-	-	NAD(P)H-dependent
BIGIONGN_04041	1.05e-87	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Chalcone and stilbene synthases, N-terminal domain
BIGIONGN_04042	6.3e-151	ycfA	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_04043	1.48e-253	ybhR	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
BIGIONGN_04044	9.79e-184	ybhF_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
BIGIONGN_04045	1.09e-114	-	-	-	M	ko:K01993	-	ko00000	PFAM secretion protein HlyD family protein
BIGIONGN_04046	3.92e-270	thrCA	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
BIGIONGN_04047	5.49e-193	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	Eukaryotic-type carbonic anhydrase
BIGIONGN_04048	5.38e-309	-	-	-	KT	-	-	-	transcriptional regulatory protein
BIGIONGN_04049	0.0	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
BIGIONGN_04050	0.0	-	-	-	H	ko:K12942	-	ko00000	AbgT putative transporter family
BIGIONGN_04051	5.18e-313	-	-	-	S	ko:K12940	-	ko00000,ko01002	Peptidase dimerisation domain
BIGIONGN_04052	7.4e-41	-	-	-	C	-	-	-	4Fe-4S binding domain
BIGIONGN_04053	4.67e-52	-	-	-	S	-	-	-	Protein of unknown function (DUF1450)
BIGIONGN_04054	6.2e-148	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Iron/manganese superoxide dismutases, C-terminal domain
BIGIONGN_04055	3.85e-151	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_04056	0.0	-	-	-	S	-	-	-	Polysaccharide biosynthesis protein
BIGIONGN_04057	1.02e-194	-	-	-	S	-	-	-	Glycosyl transferase family 2
BIGIONGN_04058	6.92e-260	-	-	-	M	-	-	-	Glycosyl transferases group 1
BIGIONGN_04059	1.97e-71	-	-	-	-	-	-	-	-
BIGIONGN_04060	3.17e-314	-	-	-	M	-	-	-	-O-antigen
BIGIONGN_04061	0.0	tuaD	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIGIONGN_04062	2.96e-91	-	-	-	-	-	-	-	-
BIGIONGN_04063	6.65e-183	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
BIGIONGN_04064	6.32e-236	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
BIGIONGN_04065	1.01e-224	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_04071	0.0	-	-	-	UW	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
BIGIONGN_04075	8.43e-49	-	-	-	-	-	-	-	-
BIGIONGN_04076	1.19e-124	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIGIONGN_04077	4.34e-39	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
BIGIONGN_04078	2.78e-88	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
BIGIONGN_04079	1.82e-227	alkA	3.2.2.21	-	L	ko:K01247,ko:K13529	ko03410,map03410	ko00000,ko00001,ko01000,ko03000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIGIONGN_04080	8.92e-273	-	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
BIGIONGN_04081	1.74e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIGIONGN_04082	2.42e-196	yxeH	-	-	S	-	-	-	hydrolases of the HAD superfamily
BIGIONGN_04083	2.65e-118	dinB	-	-	S	-	-	-	DinB family
BIGIONGN_04084	3.61e-214	yobV	-	-	K	-	-	-	WYL domain
BIGIONGN_04085	1.81e-133	-	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
BIGIONGN_04086	1.28e-165	-	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_04087	5.74e-241	-	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIGIONGN_04089	1.83e-151	yhcZ	-	-	K	ko:K02479	-	ko00000,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
BIGIONGN_04090	1.8e-270	yhcY	2.7.13.3	-	T	ko:K02480	-	ko00000,ko01000,ko01001,ko02022	Histidine kinase
BIGIONGN_04091	1.59e-53	-	-	-	-	-	-	-	-
BIGIONGN_04092	6.92e-193	yrzF	-	-	KLT	-	-	-	serine threonine protein kinase
BIGIONGN_04093	2.08e-112	-	-	-	K	-	-	-	Transcriptional regulator
BIGIONGN_04094	9.84e-181	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
BIGIONGN_04095	1.39e-142	-	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	2-dehydro-3-deoxy-phosphogluconate aldolase
BIGIONGN_04097	3.25e-185	-	-	-	-	-	-	-	-
BIGIONGN_04098	8.03e-160	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_04099	7.5e-83	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
BIGIONGN_04101	1.99e-175	-	-	-	-	-	-	-	-
BIGIONGN_04102	1.85e-204	-	-	-	S	-	-	-	NYN domain
BIGIONGN_04103	6.15e-70	-	-	-	K	-	-	-	sequence-specific DNA binding
BIGIONGN_04104	0.0	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
BIGIONGN_04105	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_04106	2.52e-208	-	-	-	G	ko:K02025,ko:K17238	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_04107	1.77e-203	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_04108	7.22e-262	-	-	-	E	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
BIGIONGN_04109	2.18e-148	-	-	-	-	-	-	-	-
BIGIONGN_04111	3.43e-236	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
BIGIONGN_04113	2.37e-224	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
BIGIONGN_04114	4.03e-207	lplC7	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
BIGIONGN_04115	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
BIGIONGN_04116	0.0	-	3.2.1.80	-	G	ko:K03332	ko00051,map00051	ko00000,ko00001,ko01000	invertase
BIGIONGN_04117	0.0	cscA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
BIGIONGN_04118	4.11e-173	fabG9	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
BIGIONGN_04119	9.52e-285	yaaH	-	-	M	ko:K06306	-	ko00000	Glycoside Hydrolase Family
BIGIONGN_04120	2.24e-37	-	-	-	-	-	-	-	-
BIGIONGN_04121	1.82e-130	pncA	-	-	Q	-	-	-	COG1335 Amidases related to nicotinamidase
BIGIONGN_04122	8.45e-147	ymaB	-	-	S	-	-	-	MutT family
BIGIONGN_04123	1.08e-246	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGIONGN_04124	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIGIONGN_04125	2.08e-85	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
BIGIONGN_04126	2.39e-179	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
BIGIONGN_04127	2.9e-255	-	-	-	M	-	-	-	Glycosyltransferase like family 2
BIGIONGN_04128	0.0	tuaA	-	-	M	-	-	-	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
BIGIONGN_04129	4.63e-299	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIGIONGN_04130	1.68e-176	-	-	-	I	-	-	-	CDP-alcohol phosphatidyltransferase
BIGIONGN_04131	7.06e-93	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase
BIGIONGN_04132	0.0	-	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
BIGIONGN_04133	0.0	-	-	-	M	-	-	-	Glycosyltransferase like family 2
BIGIONGN_04134	1.2e-207	-	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
BIGIONGN_04135	1.06e-261	dhaT	1.1.1.202	-	C	ko:K00086	ko00561,ko00640,map00561,map00640	ko00000,ko00001,ko01000	alcohol dehydrogenase
BIGIONGN_04136	3.81e-17	-	-	-	-	-	-	-	-
BIGIONGN_04137	0.0	cckA	2.7.13.3	-	T	ko:K02482	-	ko00000,ko01000,ko01001,ko02022	GAF domain
BIGIONGN_04138	0.0	-	-	-	T	ko:K02481	-	ko00000,ko02022	Sigma-54 interaction domain
BIGIONGN_04139	2.04e-254	adhA	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
BIGIONGN_04140	0.0	dhaS	1.2.1.3, 1.2.1.39	-	C	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
BIGIONGN_04141	2.83e-236	-	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
BIGIONGN_04143	0.0	yaaO	-	-	E	-	-	-	Orn Lys Arg decarboxylase
BIGIONGN_04144	2.23e-149	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIGIONGN_04145	1.19e-71	yaaQ	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_04146	2.59e-234	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
BIGIONGN_04147	6.33e-189	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
BIGIONGN_04148	2.97e-60	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
BIGIONGN_04149	1.14e-175	yabB	2.1.1.223	-	S	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Conserved hypothetical protein 95
BIGIONGN_04150	1.29e-58	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
BIGIONGN_04151	1.46e-205	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIGIONGN_04152	3.04e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	COG2002 Regulators of stationary sporulation gene expression
BIGIONGN_04153	1.49e-225	-	-	-	S	-	-	-	NurA
BIGIONGN_04154	0.0	-	-	-	S	ko:K06915	-	ko00000	Domain of unknown function DUF87
BIGIONGN_04155	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIGIONGN_04156	4.87e-106	-	-	-	K	-	-	-	DNA-binding transcription factor activity
BIGIONGN_04157	4.95e-239	pelB	4.2.2.2	-	G	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Amb_all
BIGIONGN_04159	0.0	-	-	-	S	-	-	-	ABC transporter
BIGIONGN_04160	4.01e-154	-	-	-	T	-	-	-	protein histidine kinase activity
BIGIONGN_04161	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3298)
BIGIONGN_04162	1.63e-187	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD
BIGIONGN_04163	2.23e-285	yabE	-	-	T	-	-	-	protein conserved in bacteria
BIGIONGN_04164	9.52e-149	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIGIONGN_04165	2.8e-202	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
BIGIONGN_04166	4.38e-209	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
BIGIONGN_04167	4.02e-53	veg	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_04168	1.8e-34	sspF	-	-	S	ko:K06423	-	ko00000	DNA topological change
BIGIONGN_04169	2.35e-211	ispE	2.7.1.148	-	I	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIGIONGN_04170	2.69e-191	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
BIGIONGN_04171	9.96e-82	yabJ	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	translation initiation inhibitor, yjgF family
BIGIONGN_04172	2.26e-64	spoVG	-	-	D	ko:K06412	-	ko00000	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
BIGIONGN_04173	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIGIONGN_04174	6.02e-219	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIGIONGN_04175	1.95e-141	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BIGIONGN_04176	7.69e-134	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
BIGIONGN_04177	2.11e-52	yabK	-	-	S	-	-	-	Peptide ABC transporter permease
BIGIONGN_04178	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIGIONGN_04179	2.3e-123	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein
BIGIONGN_04180	2.75e-135	-	-	-	S	-	-	-	Yip1 domain
BIGIONGN_04181	1.43e-252	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIGIONGN_04182	8.06e-115	-	-	-	S	-	-	-	Yip1 domain
BIGIONGN_04183	0.0	yabM	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
BIGIONGN_04184	0.0	yabN	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
BIGIONGN_04185	2.69e-43	yabO	-	-	J	-	-	-	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
BIGIONGN_04186	4.84e-152	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
BIGIONGN_04187	1.74e-225	yvcT	1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81	-	CH	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIGIONGN_04188	1.12e-114	-	2.3.1.128	-	K	ko:K03790	-	ko00000,ko01000,ko03009	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
BIGIONGN_04189	5.82e-255	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
BIGIONGN_04190	2.83e-134	-	-	-	S	-	-	-	SNARE associated Golgi protein
BIGIONGN_04191	6.77e-71	yabP	-	-	S	-	-	-	Sporulation protein YabP
BIGIONGN_04192	1.33e-94	yabQ	-	-	S	-	-	-	spore cortex biosynthesis protein
BIGIONGN_04193	1.73e-80	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
BIGIONGN_04194	7.4e-93	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
BIGIONGN_04196	2.07e-284	citM	-	-	C	ko:K03300	-	ko00000	Citrate transporter
BIGIONGN_04197	0.0	spoIIE	3.1.3.16	-	KT	ko:K06382	-	ko00000,ko01000	stage II sporulation protein E
BIGIONGN_04198	2.67e-166	yabS	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
BIGIONGN_04199	5.96e-226	yabT	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	serine threonine protein kinase
BIGIONGN_04200	0.0	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
BIGIONGN_04201	2.21e-121	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIGIONGN_04202	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIGIONGN_04203	6.12e-182	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIGIONGN_04204	3.73e-207	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIGIONGN_04205	1.13e-221	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
BIGIONGN_04206	0.0	pabB	2.6.1.85	-	EH	ko:K01665	ko00790,map00790	ko00000,ko00001,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIGIONGN_04207	2.26e-141	pabA	2.6.1.85	-	EH	ko:K01664	ko00790,map00790	ko00000,ko00001,ko01000	Anthranilate synthase
BIGIONGN_04208	4.52e-200	pabC	4.1.3.38	-	EH	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	4-amino-4-deoxychorismate lyase
BIGIONGN_04209	7.44e-192	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIGIONGN_04210	7.65e-83	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIGIONGN_04211	1.3e-121	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIGIONGN_04212	2.17e-241	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIGIONGN_04213	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
BIGIONGN_04214	4.79e-95	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
BIGIONGN_04215	4.37e-124	mcsA	-	-	S	ko:K19411	-	ko00000	protein with conserved CXXC pairs
BIGIONGN_04216	6.55e-251	mcsB	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
BIGIONGN_04217	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
BIGIONGN_04218	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIGIONGN_04219	4.09e-249	disA	2.7.7.85	-	L	ko:K07067	-	ko00000,ko01000	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BIGIONGN_04220	1.18e-253	yacL	-	-	S	-	-	-	COG4956 Integral membrane protein (PIN domain superfamily)
BIGIONGN_04221	1.67e-152	ispD	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
BIGIONGN_04222	1.09e-109	ispF	2.7.7.60, 4.6.1.12	-	I	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
BIGIONGN_04223	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIGIONGN_04224	9.81e-157	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
BIGIONGN_04225	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
BIGIONGN_04226	1.04e-91	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BIGIONGN_04227	2.3e-185	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIGIONGN_04228	8.14e-115	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
BIGIONGN_04229	4.15e-153	comX	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
BIGIONGN_04230	2.37e-34	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
BIGIONGN_04231	1.83e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
BIGIONGN_04232	1.19e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIGIONGN_04233	4.64e-160	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
BIGIONGN_04234	8.48e-106	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIGIONGN_04235	1.27e-69	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
BIGIONGN_04236	1.45e-157	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
BIGIONGN_04237	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGIONGN_04238	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGIONGN_04239	1.84e-47	rplGB	-	-	J	ko:K07590	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the eukaryotic ribosomal protein eL8 family
BIGIONGN_04240	4.33e-95	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIGIONGN_04241	1.19e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
BIGIONGN_04242	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIGIONGN_04243	7.02e-288	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIGIONGN_04244	2.58e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
BIGIONGN_04245	9.49e-143	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIGIONGN_04246	5.45e-138	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
BIGIONGN_04247	9.74e-60	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
BIGIONGN_04248	3.58e-200	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIGIONGN_04249	2.63e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIGIONGN_04250	8.5e-72	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BIGIONGN_04251	1.76e-154	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIGIONGN_04252	3.79e-101	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIGIONGN_04253	5.12e-38	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
BIGIONGN_04254	2.17e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIGIONGN_04255	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIGIONGN_04256	7.7e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIGIONGN_04257	2.21e-121	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIGIONGN_04258	1e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIGIONGN_04259	2.66e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIGIONGN_04260	6.37e-125	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIGIONGN_04261	8.96e-79	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIGIONGN_04262	1.59e-110	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BIGIONGN_04263	7.06e-36	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
BIGIONGN_04264	9.26e-98	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
BIGIONGN_04265	4.17e-298	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
BIGIONGN_04266	8.08e-154	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
BIGIONGN_04267	9.44e-182	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
BIGIONGN_04268	4.15e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIGIONGN_04269	5.99e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
BIGIONGN_04270	8.92e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BIGIONGN_04271	4.05e-85	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIGIONGN_04272	4.06e-216	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIGIONGN_04273	3.65e-78	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
BIGIONGN_04274	8.83e-208	cbiO	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGIONGN_04275	6.38e-197	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGIONGN_04276	1.42e-175	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIGIONGN_04277	4.15e-187	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
BIGIONGN_04278	2.77e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIGIONGN_04279	4.45e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
BIGIONGN_04281	5.37e-107	-	-	-	S	-	-	-	Protein of unknown function (DUF2975)
BIGIONGN_04282	1.08e-41	yozG	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
BIGIONGN_04284	0.000234	ykkB	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
BIGIONGN_04285	3.65e-105	ybaK	-	-	S	-	-	-	Protein of unknown function (DUF2521)
BIGIONGN_04286	8.67e-171	cwlD	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
BIGIONGN_04287	8.39e-196	glcT	-	-	K	ko:K03480,ko:K03488	-	ko00000,ko03000	antiterminator
BIGIONGN_04288	0.0	ptsG	2.7.1.199	-	G	ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_04289	6.51e-247	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
BIGIONGN_04290	2.04e-28	lacF	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
BIGIONGN_04291	1.34e-95	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIGIONGN_04292	1.67e-40	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PFAM Phosphotransferase system, lactose cellobiose-specific IIB subunit
BIGIONGN_04293	1.17e-220	-	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
BIGIONGN_04294	3.36e-92	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
BIGIONGN_04295	1.29e-214	-	-	-	S	-	-	-	Protein of unknown function (DUF4127)
BIGIONGN_04296	7.85e-120	-	-	-	K	-	-	-	transcriptional regulator, RpiR family
BIGIONGN_04297	6.68e-96	gerD	-	-	S	ko:K06294	-	ko00000	Spore gernimation protein
BIGIONGN_04298	1.14e-129	kbaA	-	-	S	ko:K06349	-	ko00000	Involved in the activation of the KinB signaling pathway of sporulation
BIGIONGN_04299	5.05e-184	pdaB	-	-	G	-	-	-	Polysaccharide deacetylase
BIGIONGN_04300	5.74e-46	-	-	-	-	-	-	-	-
BIGIONGN_04303	0.0	-	-	-	M	-	-	-	cell wall anchor domain
BIGIONGN_04304	3.1e-110	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
BIGIONGN_04305	3.21e-173	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_04306	2.25e-206	-	2.7.1.190	-	S	ko:K17910	-	ko00000,ko01000,ko01504	Protein of unknown function (DUF1679)
BIGIONGN_04307	1.12e-151	-	-	-	O	-	-	-	Sap, sulfolipid-1-addressing protein
BIGIONGN_04308	3.65e-94	-	-	-	-	-	-	-	-
BIGIONGN_04309	1.14e-186	-	-	-	K	-	-	-	MerR family transcriptional regulator
BIGIONGN_04310	2.26e-211	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
BIGIONGN_04311	2.04e-232	-	-	-	M	-	-	-	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain
BIGIONGN_04312	3.65e-174	-	-	-	KT	-	-	-	Transcriptional regulator containing PAS AAA-type ATPase and DNA-binding
BIGIONGN_04314	2.79e-145	-	-	-	S	-	-	-	Protein of unknown function (DUF2812)
BIGIONGN_04315	5.69e-63	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
BIGIONGN_04316	1.15e-73	yqjZ	-	-	S	-	-	-	enzyme involved in biosynthesis of extracellular polysaccharides
BIGIONGN_04317	2.07e-32	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
BIGIONGN_04318	4.8e-93	-	-	-	-	-	-	-	-
BIGIONGN_04319	2.12e-100	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_04320	1.48e-247	bdhA	1.1.1.264, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00098	ko00650,map00650	ko00000,ko00001,ko01000	Dehydrogenase
BIGIONGN_04321	8.8e-140	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
BIGIONGN_04322	0.0	gsiB_3	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_04323	1.95e-13	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
BIGIONGN_04325	1.62e-11	-	-	-	-	-	-	-	-
BIGIONGN_04332	5.59e-128	sigW	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
BIGIONGN_04333	2.31e-155	rsiW	-	-	K	-	-	-	Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
BIGIONGN_04334	6.84e-188	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIGIONGN_04335	3.74e-284	ybbR	-	-	S	-	-	-	protein conserved in bacteria
BIGIONGN_04336	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIGIONGN_04338	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
BIGIONGN_04339	2.52e-199	ybfI	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_04340	4.98e-222	-	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
BIGIONGN_04342	0.0	-	-	-	S	-	-	-	Aminoglycoside phosphotransferase
BIGIONGN_04343	1.43e-96	-	-	-	K	-	-	-	SpoVT / AbrB like domain
BIGIONGN_04344	3.86e-282	yjiC	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
BIGIONGN_04345	3.27e-183	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_04346	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
BIGIONGN_04347	6.12e-157	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
BIGIONGN_04348	3.78e-248	-	-	-	T	-	-	-	Histidine kinase-like ATPases
BIGIONGN_04349	5.04e-147	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_04350	7.66e-292	-	-	-	EGP	-	-	-	Transmembrane secretion effector
BIGIONGN_04351	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
BIGIONGN_04352	1.41e-80	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_04353	2.48e-77	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
BIGIONGN_04354	4.39e-76	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	GntR family transcriptional regulator
BIGIONGN_04355	2.17e-207	CcmA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
BIGIONGN_04356	1.97e-128	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
BIGIONGN_04357	1.83e-230	-	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIGIONGN_04359	7.93e-196	penP	3.5.2.6	-	V	ko:K17836,ko:K18766	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	beta-lactamase
BIGIONGN_04360	0.0	mecR1	-	-	KTV	ko:K02172,ko:K02547	ko01501,map01501	ko00000,ko00001,ko00002,ko01002,ko01504	BlaR1 peptidase M56
BIGIONGN_04361	1.29e-83	blaI	-	-	K	ko:K02171,ko:K02546	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Penicillinase repressor
BIGIONGN_04362	7.76e-185	-	-	-	H	ko:K17882	-	ko00000,ko01000,ko01504	KNTase C-terminal domain
BIGIONGN_04363	3.43e-78	-	-	-	K	ko:K21903	-	ko00000,ko03000	transcriptional
BIGIONGN_04364	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
BIGIONGN_04365	3.91e-262	trkA	-	-	P	ko:K07222	-	ko00000	Oxidoreductase
BIGIONGN_04366	3.88e-118	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_04367	6.21e-119	-	-	-	-	-	-	-	-
BIGIONGN_04368	2.91e-186	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
BIGIONGN_04369	2.32e-234	-	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
BIGIONGN_04370	1.46e-156	-	-	-	Q	-	-	-	SAM-dependent methyltransferase
BIGIONGN_04371	2.01e-185	-	-	-	EG	-	-	-	EamA-like transporter family
BIGIONGN_04372	2.01e-167	-	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
BIGIONGN_04373	1.36e-145	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_04374	4.71e-87	-	-	-	-	-	-	-	-
BIGIONGN_04375	9.99e-93	-	-	-	S	-	-	-	Protein of unknown function (DUF2512)
BIGIONGN_04376	1.21e-148	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
BIGIONGN_04377	8.04e-111	-	2.3.1.128	-	J	ko:K03789,ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_04378	1.35e-51	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
BIGIONGN_04379	1.57e-41	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
BIGIONGN_04381	2.72e-240	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
BIGIONGN_04382	5.27e-280	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
BIGIONGN_04383	1.42e-218	yfiL	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
BIGIONGN_04384	3.54e-140	-	-	-	KT	-	-	-	LuxR family transcriptional regulator
BIGIONGN_04385	4.78e-253	-	-	-	T	-	-	-	Signal transduction histidine kinase
BIGIONGN_04386	2.73e-118	ttr	-	-	K	-	-	-	GCN5 family acetyltransferase
BIGIONGN_04387	1.41e-196	fhuD9	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
BIGIONGN_04388	6.58e-175	-	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_04389	2.05e-296	gntT	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
BIGIONGN_04390	1.14e-254	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
BIGIONGN_04391	1.68e-176	-	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_04392	2.25e-240	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
BIGIONGN_04393	2.42e-261	-	3.4.17.11	-	E	ko:K01295	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
BIGIONGN_04394	3.08e-302	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
BIGIONGN_04395	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
BIGIONGN_04396	1.21e-130	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIGIONGN_04397	2.04e-252	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
BIGIONGN_04398	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIGIONGN_04399	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGIONGN_04400	6.66e-167	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGIONGN_04401	5.87e-51	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIGIONGN_04402	1.13e-164	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
BIGIONGN_04403	0.0	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIGIONGN_04404	2.02e-270	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIGIONGN_04405	5.56e-105	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIGIONGN_04406	5.38e-166	-	-	-	S	-	-	-	CAAX protease self-immunity
BIGIONGN_04407	1.62e-134	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
BIGIONGN_04408	4.2e-157	-	-	-	S	-	-	-	PFAM AIG2 family protein
BIGIONGN_04409	1.66e-144	-	-	-	-	-	-	-	-
BIGIONGN_04410	8.23e-89	-	-	-	S	-	-	-	Calcium/calmodulin dependent protein kinase II association domain
BIGIONGN_04411	4.15e-42	yebG	-	-	S	-	-	-	NETI protein
BIGIONGN_04412	1.05e-16	-	-	-	L	-	-	-	Initiator Replication protein
BIGIONGN_04413	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
BIGIONGN_04414	1.7e-96	-	-	-	S	ko:K07794	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctB family
BIGIONGN_04415	1.41e-243	-	-	-	S	ko:K07795	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter family receptor
BIGIONGN_04417	3.83e-155	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
BIGIONGN_04418	0.0	-	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
BIGIONGN_04419	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	COG0025 NhaP-type Na H and K H antiporters
BIGIONGN_04421	5.78e-28	fliA	-	-	K	ko:K02405,ko:K03093	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	sigma factor activity
BIGIONGN_04422	6.9e-27	-	-	-	S	-	-	-	YvrJ protein family
BIGIONGN_04423	1.11e-180	-	-	-	-	-	-	-	-
BIGIONGN_04424	4.34e-73	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
BIGIONGN_04425	3.33e-190	-	-	-	-	-	-	-	-
BIGIONGN_04427	0.0	yheH	-	-	V	ko:K18217,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_04428	0.0	yheI	-	-	V	ko:K18216,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
BIGIONGN_04429	1.46e-16	-	-	-	L	ko:K07496	-	ko00000	Transposase
BIGIONGN_04431	3.86e-299	-	-	-	G	-	-	-	Major facilitator Superfamily
BIGIONGN_04434	4.81e-127	ypbQ	-	-	S	ko:K16168	-	ko00000,ko01008	protein conserved in bacteria
BIGIONGN_04435	2.54e-268	bcsA	-	-	Q	ko:K16167	-	ko00000,ko01008	Naringenin-chalcone synthase
BIGIONGN_04436	2.98e-166	mta	-	-	K	-	-	-	transcriptional
BIGIONGN_04437	1.92e-152	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_04438	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
BIGIONGN_04439	2.01e-206	kduI	5.3.1.17	-	G	ko:K01815	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BIGIONGN_04440	6.31e-172	kduD	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
BIGIONGN_04441	7.11e-174	-	-	-	K	-	-	-	DeoR C terminal sensor domain
BIGIONGN_04442	5.61e-115	-	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
BIGIONGN_04443	6.75e-138	ywrB	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
BIGIONGN_04444	2.01e-206	mqnD	-	-	S	ko:K11785	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BIGIONGN_04445	1.42e-146	mqnB	3.2.2.26	-	F	ko:K11783	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BIGIONGN_04446	0.0	lipA1	-	-	S	-	-	-	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIGIONGN_04447	0.0	-	-	-	K	ko:K02538	-	ko00000,ko03000	transcriptional antiterminator
BIGIONGN_04448	1.07e-134	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
BIGIONGN_04449	0.0	-	-	-	M	-	-	-	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIGIONGN_04466	0.0	yobO	-	-	M	-	-	-	Pectate lyase superfamily protein
BIGIONGN_04468	6.43e-48	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
BIGIONGN_04469	1.6e-63	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
BIGIONGN_04470	2.24e-64	-	-	-	K	-	-	-	ArsR family transcriptional regulator
BIGIONGN_04471	1.95e-257	ybcL	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
BIGIONGN_04472	0.0	yhjG	-	-	CH	-	-	-	FAD binding domain
BIGIONGN_04473	5.57e-86	-	-	-	J	-	-	-	oxidation-reduction process
BIGIONGN_04474	1.68e-108	yhjH	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
BIGIONGN_04475	1.85e-220	-	-	-	S	-	-	-	thiolester hydrolase activity
BIGIONGN_04476	9.23e-292	-	3.3.2.9	-	S	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	ko00000,ko00001,ko01000,ko01002	Epoxide hydrolase N terminus
BIGIONGN_04477	2.55e-13	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIGIONGN_04478	0.0	nox	1.11.1.1	-	P	ko:K05910	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
BIGIONGN_04479	8.8e-140	-	-	-	K	-	-	-	Bacterial transcriptional repressor C-terminal
BIGIONGN_04481	1.18e-116	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_04482	0.0	pbpE	-	-	V	-	-	-	Beta-lactamase
BIGIONGN_04483	8.96e-59	ykvN	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGIONGN_04484	2.07e-43	yjcS	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
BIGIONGN_04485	7.19e-260	yerI	-	-	S	-	-	-	homoserine kinase type II (protein kinase fold)
BIGIONGN_04486	2.36e-213	-	-	-	K	-	-	-	AraC-like ligand binding domain
BIGIONGN_04487	0.0	lacZ	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	beta-galactosidase
BIGIONGN_04488	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
BIGIONGN_04489	3.04e-278	-	3.5.2.3	-	S	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	amidohydrolase
BIGIONGN_04490	1.88e-67	-	-	-	S	-	-	-	PRD domain
BIGIONGN_04491	9.35e-80	-	-	-	S	-	-	-	Glycine-rich SFCGS
BIGIONGN_04492	6.36e-78	-	-	-	S	-	-	-	Domain of unknown function (DUF4312)
BIGIONGN_04493	9.36e-179	-	-	-	S	-	-	-	Domain of unknown function (DUF4311)
BIGIONGN_04494	8.24e-146	-	-	-	S	-	-	-	Domain of unknown function (DUF4310)
BIGIONGN_04495	8.41e-260	selA	2.9.1.1	-	E	ko:K01042	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko01000	L-seryl-tRNA selenium transferase
BIGIONGN_04496	9.27e-159	-	4.1.2.14	-	S	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	ko00000,ko00001,ko00002,ko01000	KDGP aldolase
BIGIONGN_04497	0.000685	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
BIGIONGN_04498	2.5e-233	pld1	1.1.1.122	-	C	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Aldo/keto reductase family
BIGIONGN_04499	8.81e-92	-	-	-	H	-	-	-	RibD C-terminal domain
BIGIONGN_04500	6.9e-77	-	-	-	S	-	-	-	YjbR
BIGIONGN_04501	6.33e-73	-	-	-	S	-	-	-	Glyoxalase-like domain
BIGIONGN_04502	5.31e-187	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
BIGIONGN_04503	3.69e-124	-	-	-	K	-	-	-	Winged helix DNA-binding domain
BIGIONGN_04504	1.45e-191	-	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
BIGIONGN_04505	8.9e-137	-	-	-	K	-	-	-	TetR family transcriptional regulator
BIGIONGN_04506	1e-271	-	-	-	CH	-	-	-	FAD binding domain
BIGIONGN_04507	1.27e-275	-	-	-	EGP	-	-	-	Transmembrane secretion effector
BIGIONGN_04508	3.92e-142	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
BIGIONGN_04509	1.58e-173	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
BIGIONGN_04510	2.08e-146	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
BIGIONGN_04511	5.82e-220	-	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Arginase family
BIGIONGN_04512	4.23e-76	ydzF	-	-	K	-	-	-	HxlR-like helix-turn-helix
BIGIONGN_04513	3.41e-78	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
BIGIONGN_04514	7.2e-76	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
BIGIONGN_04515	1.91e-37	rmeD	-	-	K	ko:K13640	-	ko00000,ko03000	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BIGIONGN_04516	1.48e-112	-	-	-	C	-	-	-	aldo keto reductase
BIGIONGN_04517	2.09e-62	-	-	-	K	-	-	-	MarR family
BIGIONGN_04518	9.72e-127	-	-	-	EP	ko:K15585	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
BIGIONGN_04519	1.21e-135	nikC	-	-	P	ko:K02034,ko:K15586	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	With NikABDE is involved in nickel transport into the cell
BIGIONGN_04520	1.47e-112	nikD	3.6.3.24	-	EP	ko:K02031,ko:K15587	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	ABC-type dipeptide oligopeptide nickel transport system, ATPase component
BIGIONGN_04521	1.8e-121	nikE	3.6.3.24	-	E	ko:K02031,ko:K02032,ko:K10824	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
BIGIONGN_04522	3.36e-265	nikA	-	-	E	ko:K15584	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
BIGIONGN_04523	1.09e-193	yaaC	-	-	S	-	-	-	YaaC-like Protein
BIGIONGN_04524	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
BIGIONGN_04525	5.9e-307	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
BIGIONGN_04526	3.3e-282	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIGIONGN_04527	5.15e-192	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
BIGIONGN_04528	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
BIGIONGN_04529	0.0	rocR	-	-	KT	ko:K06714	-	ko00000,ko03000	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
BIGIONGN_04530	7.18e-301	rocD	2.6.1.13	-	E	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Catalyzes the interconversion of ornithine to glutamate semialdehyde
BIGIONGN_04531	3.54e-06	gudB	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
BIGIONGN_04532	0.0	nhaC_2	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
BIGIONGN_04534	1.05e-298	-	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
BIGIONGN_04535	5.83e-293	-	2.5.1.48, 4.4.1.11	-	E	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
BIGIONGN_04536	2.17e-287	-	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
BIGIONGN_04537	7.29e-245	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
BIGIONGN_04538	0.0	gabD_2	1.2.1.9	-	C	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
BIGIONGN_04539	6.29e-84	-	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
BIGIONGN_04540	8.69e-187	glnH	-	-	ET	ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Ligated ion channel L-glutamate- and glycine-binding site
BIGIONGN_04541	2.49e-141	glnP	-	-	E	ko:K02029,ko:K10037,ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Polar amino acid ABC transporter, inner membrane subunit
BIGIONGN_04542	3.01e-165	-	3.6.3.21	-	E	ko:K02028,ko:K10038	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
BIGIONGN_04543	4.05e-244	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_04544	4.75e-247	-	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
BIGIONGN_04545	3.19e-214	-	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_04546	3.86e-205	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIGIONGN_04547	0.0	gsiB_3	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
BIGIONGN_04549	1.31e-113	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
BIGIONGN_04550	1.8e-136	clpP1	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
BIGIONGN_04551	1.99e-155	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70, region 4
BIGIONGN_04552	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIGIONGN_04553	4.53e-51	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIGIONGN_04554	2.64e-141	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIGIONGN_04555	6.78e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
BIGIONGN_04556	2.37e-27	bofA	-	-	S	ko:K06317	-	ko00000	Sigma-K factor-processing regulatory protein BofA
BIGIONGN_04557	3e-138	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
BIGIONGN_04558	1.43e-130	-	-	-	-	-	-	-	-
BIGIONGN_04559	5.31e-149	yahD	-	-	S	ko:K06999	-	ko00000	Carboxylesterase
BIGIONGN_04560	8.79e-239	ykcA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
BIGIONGN_04561	1.41e-28	-	-	-	-	-	-	-	-
BIGIONGN_04562	9.4e-198	ycsE	-	-	S	-	-	-	hydrolases of the HAD superfamily
BIGIONGN_04563	3.72e-116	-	-	-	-	-	-	-	-
BIGIONGN_04564	2.9e-05	-	-	-	S	ko:K06376	-	ko00000	Spo0E like sporulation regulatory protein
BIGIONGN_04565	1.59e-101	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter transmembrane region
BIGIONGN_04566	5.42e-279	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
BIGIONGN_04576	5.42e-84	-	-	-	V	ko:K06147	-	ko00000,ko02000	Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation