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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
HFNEBIIC_00001	4.72e-134	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HFNEBIIC_00011	5.82e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HFNEBIIC_00012	3.71e-293	lmrB	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Belongs to the major facilitator superfamily
HFNEBIIC_00013	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
HFNEBIIC_00014	1.61e-143	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFNEBIIC_00015	1.06e-202	-	-	-	O	-	-	-	Uncharacterized protein family (UPF0051)
HFNEBIIC_00016	2.14e-146	-	-	-	M	-	-	-	LysM domain protein
HFNEBIIC_00017	0.0	-	-	-	EP	-	-	-	Psort location Cytoplasmic, score
HFNEBIIC_00018	1.02e-132	-	-	-	M	-	-	-	LysM domain protein
HFNEBIIC_00020	2.96e-285	aadAT	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	Aminotransferase, class I
HFNEBIIC_00021	8.31e-158	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HFNEBIIC_00022	1.39e-92	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HFNEBIIC_00023	1.1e-126	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
HFNEBIIC_00024	7.11e-32	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HFNEBIIC_00025	9.18e-31	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HFNEBIIC_00026	7.41e-175	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFNEBIIC_00027	2.95e-92	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HFNEBIIC_00028	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HFNEBIIC_00029	5.49e-262	yacL	-	-	S	-	-	-	domain protein
HFNEBIIC_00030	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HFNEBIIC_00031	8.07e-128	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTP diphosphatase
HFNEBIIC_00032	4.04e-67	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
HFNEBIIC_00033	2.92e-161	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HFNEBIIC_00034	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
HFNEBIIC_00035	3.37e-178	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
HFNEBIIC_00036	1.18e-171	-	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_00037	3.36e-154	tcyB	-	-	E	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HFNEBIIC_00038	2.12e-274	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HFNEBIIC_00039	4.95e-213	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HFNEBIIC_00040	5.05e-171	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFNEBIIC_00041	0.0	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
HFNEBIIC_00042	4.33e-232	lacM	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase
HFNEBIIC_00043	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
HFNEBIIC_00045	5.32e-108	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
HFNEBIIC_00046	0.0	tex	-	-	K	ko:K06959	-	ko00000	Tex-like protein N-terminal domain protein
HFNEBIIC_00047	1.51e-196	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HFNEBIIC_00048	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFNEBIIC_00049	5.88e-164	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
HFNEBIIC_00050	2.49e-168	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
HFNEBIIC_00051	0.0	-	-	-	P	ko:K07085	-	ko00000	Predicted Permease Membrane Region
HFNEBIIC_00052	1.78e-316	-	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_00053	8.98e-143	-	-	-	-	-	-	-	-
HFNEBIIC_00056	4.82e-189	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HFNEBIIC_00057	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
HFNEBIIC_00061	2.4e-19	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HFNEBIIC_00063	7.61e-169	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_00064	4.36e-22	-	-	-	-	-	-	-	-
HFNEBIIC_00065	1.14e-69	-	-	-	S	-	-	-	Plasmid replication protein
HFNEBIIC_00070	1.99e-14	-	-	-	D	-	-	-	nuclear chromosome segregation
HFNEBIIC_00071	5.68e-30	-	-	-	K	-	-	-	Helix-turn-helix domain
HFNEBIIC_00075	2.23e-124	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
HFNEBIIC_00076	1.49e-276	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
HFNEBIIC_00077	5.4e-63	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
HFNEBIIC_00078	4.03e-157	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFNEBIIC_00079	4.03e-143	yqeK	-	-	H	-	-	-	Hydrolase, HD family
HFNEBIIC_00080	1.1e-78	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HFNEBIIC_00081	5.88e-175	yqeM	-	-	Q	-	-	-	Methyltransferase
HFNEBIIC_00082	2.45e-267	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
HFNEBIIC_00083	1.01e-129	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
HFNEBIIC_00084	7.21e-39	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
HFNEBIIC_00085	9.72e-156	csrR	-	-	K	-	-	-	response regulator
HFNEBIIC_00086	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HFNEBIIC_00087	9.5e-39	potE	-	-	E	-	-	-	Amino Acid
HFNEBIIC_00088	1.3e-230	potE	-	-	E	-	-	-	Amino Acid
HFNEBIIC_00089	1.06e-297	-	-	-	V	-	-	-	MatE
HFNEBIIC_00090	6.2e-89	def2	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
HFNEBIIC_00091	2.25e-214	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HFNEBIIC_00092	2.36e-56	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
HFNEBIIC_00093	6.37e-185	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFNEBIIC_00094	7.57e-119	XK27_09705	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HFNEBIIC_00095	5.79e-78	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HFNEBIIC_00096	3.66e-252	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFNEBIIC_00097	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HFNEBIIC_00098	2.41e-146	-	-	-	M	-	-	-	PFAM NLP P60 protein
HFNEBIIC_00099	2.8e-150	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
HFNEBIIC_00100	3.52e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HFNEBIIC_00101	2.49e-87	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
HFNEBIIC_00102	0.0	-	-	-	S	-	-	-	membrane
HFNEBIIC_00103	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HFNEBIIC_00104	1.53e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HFNEBIIC_00105	1.61e-130	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFNEBIIC_00106	9.92e-97	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
HFNEBIIC_00107	1.57e-27	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
HFNEBIIC_00108	7.07e-48	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
HFNEBIIC_00109	8.4e-234	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
HFNEBIIC_00110	1.09e-87	yqhL	-	-	P	-	-	-	Rhodanese-like protein
HFNEBIIC_00111	1.18e-30	-	-	-	S	-	-	-	Protein of unknown function (DUF3042)
HFNEBIIC_00112	2.29e-223	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFNEBIIC_00113	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
HFNEBIIC_00114	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFNEBIIC_00115	3.45e-119	araT	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00116	1.59e-39	araT	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00117	1.34e-49	araT	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00118	1.28e-18	-	-	-	-	-	-	-	-
HFNEBIIC_00119	6.17e-38	spxB	1.2.3.3, 1.2.5.1, 2.2.1.6, 4.1.1.8	-	EH	ko:K00156,ko:K00158,ko:K01577,ko:K01652	ko00290,ko00620,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HFNEBIIC_00120	4.87e-258	spxB	1.2.3.3, 1.2.5.1, 2.2.1.6, 4.1.1.8	-	EH	ko:K00156,ko:K00158,ko:K01577,ko:K01652	ko00290,ko00620,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HFNEBIIC_00121	2.68e-36	spxB	1.2.3.3, 1.2.5.1, 2.2.1.6, 4.1.1.8	-	EH	ko:K00156,ko:K00158,ko:K01577,ko:K01652	ko00290,ko00620,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HFNEBIIC_00122	7.72e-177	-	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
HFNEBIIC_00123	8.05e-178	-	-	-	S	-	-	-	Membrane
HFNEBIIC_00124	1.36e-96	-	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase
HFNEBIIC_00125	1.58e-22	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_00126	4.38e-205	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HFNEBIIC_00127	8.66e-70	-	-	-	S	-	-	-	Mazg nucleotide pyrophosphohydrolase
HFNEBIIC_00128	8.67e-45	-	-	-	-	-	-	-	-
HFNEBIIC_00129	3.03e-83	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HFNEBIIC_00130	0.0	-	-	-	E	ko:K03294	-	ko00000	amino acid
HFNEBIIC_00131	5.46e-183	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
HFNEBIIC_00132	5.33e-119	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFNEBIIC_00133	5.32e-53	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
HFNEBIIC_00134	1.21e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
HFNEBIIC_00135	0.0	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFNEBIIC_00136	4.23e-76	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HFNEBIIC_00137	4.26e-259	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HFNEBIIC_00138	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
HFNEBIIC_00139	6.38e-168	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HFNEBIIC_00140	1.81e-50	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFNEBIIC_00141	4.72e-241	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HFNEBIIC_00142	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFNEBIIC_00143	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
HFNEBIIC_00144	1.05e-77	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HFNEBIIC_00145	1.1e-34	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
HFNEBIIC_00146	7.8e-156	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
HFNEBIIC_00147	4.49e-151	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HFNEBIIC_00148	4.03e-207	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HFNEBIIC_00149	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HFNEBIIC_00150	6.78e-165	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
HFNEBIIC_00151	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFNEBIIC_00152	8.26e-222	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HFNEBIIC_00153	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFNEBIIC_00154	3.06e-264	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFNEBIIC_00155	6.66e-43	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HFNEBIIC_00156	3.59e-147	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
HFNEBIIC_00157	8.66e-70	-	-	-	-	-	-	-	-
HFNEBIIC_00158	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
HFNEBIIC_00159	1.85e-99	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HFNEBIIC_00160	6.61e-190	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
HFNEBIIC_00161	8.7e-199	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HFNEBIIC_00162	1.15e-57	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HFNEBIIC_00163	7.97e-280	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HFNEBIIC_00164	3.63e-189	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFNEBIIC_00165	1.84e-91	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFNEBIIC_00166	2.27e-93	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
HFNEBIIC_00167	1.73e-147	-	-	-	J	-	-	-	2'-5' RNA ligase superfamily
HFNEBIIC_00168	1.75e-255	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HFNEBIIC_00169	6.12e-167	-	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFNEBIIC_00170	5.93e-60	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
HFNEBIIC_00171	2.94e-71	ysxB	-	-	J	ko:K07584	-	ko00000	Cysteine protease Prp
HFNEBIIC_00172	2.68e-67	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
HFNEBIIC_00173	3.3e-145	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_00176	3.89e-112	-	-	-	S	-	-	-	Protein conserved in bacteria
HFNEBIIC_00177	3.38e-229	-	-	-	-	-	-	-	-
HFNEBIIC_00178	1.39e-202	-	-	-	-	-	-	-	-
HFNEBIIC_00179	3.7e-19	-	-	-	-	-	-	-	-
HFNEBIIC_00180	5.97e-265	thiP	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
HFNEBIIC_00181	1.06e-103	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HFNEBIIC_00182	6.19e-07	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HFNEBIIC_00183	9.81e-36	-	-	-	K	-	-	-	PFAM GCN5-related N-acetyltransferase
HFNEBIIC_00184	1.1e-102	-	-	-	-	-	-	-	-
HFNEBIIC_00185	1.57e-161	-	-	-	M	-	-	-	Lysin motif
HFNEBIIC_00187	0.0	snf	-	-	KL	-	-	-	domain protein
HFNEBIIC_00188	2.91e-185	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
HFNEBIIC_00189	6.19e-263	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HFNEBIIC_00190	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	Putative exonuclease SbcCD, C subunit
HFNEBIIC_00191	1.69e-134	-	-	-	L	-	-	-	nuclease
HFNEBIIC_00192	0.0	XK27_00340	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HFNEBIIC_00193	7.45e-92	-	-	-	-	-	-	-	-
HFNEBIIC_00194	1.23e-134	-	-	-	D	ko:K04095	-	ko00000,ko03036	Fic/DOC family
HFNEBIIC_00195	9.68e-159	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HFNEBIIC_00196	1.83e-194	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
HFNEBIIC_00197	1.2e-34	-	-	-	-	-	-	-	-
HFNEBIIC_00198	1.07e-187	-	-	-	-	-	-	-	-
HFNEBIIC_00200	8.99e-141	XK27_07085	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HFNEBIIC_00201	1.78e-42	-	-	-	-	-	-	-	-
HFNEBIIC_00202	1.7e-209	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFNEBIIC_00203	3.58e-238	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HFNEBIIC_00204	1.53e-146	-	-	-	-	-	-	-	-
HFNEBIIC_00205	3.06e-150	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
HFNEBIIC_00206	2.83e-225	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HFNEBIIC_00207	2.18e-112	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
HFNEBIIC_00208	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
HFNEBIIC_00209	4.13e-195	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFNEBIIC_00210	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HFNEBIIC_00211	1.77e-56	-	-	-	-	-	-	-	-
HFNEBIIC_00212	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
HFNEBIIC_00213	2.71e-280	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HFNEBIIC_00214	1.82e-120	tag1	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HFNEBIIC_00215	0.0	-	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_00216	1.46e-110	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
HFNEBIIC_00217	2.01e-302	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HFNEBIIC_00218	1.13e-132	-	-	-	V	-	-	-	VanZ like family
HFNEBIIC_00219	7.03e-33	-	-	-	-	-	-	-	-
HFNEBIIC_00220	1e-101	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HFNEBIIC_00221	4.4e-101	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
HFNEBIIC_00222	0.0	umuC	-	-	L	ko:K03502	-	ko00000,ko03400	impB/mucB/samB family C-terminal domain
HFNEBIIC_00223	1.55e-99	hsp	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HFNEBIIC_00224	2.6e-196	yeaE	-	-	S	-	-	-	Aldo keto
HFNEBIIC_00225	3.25e-309	-	1.3.1.1	-	C	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	4Fe-4S dicluster domain
HFNEBIIC_00226	6.62e-297	-	1.3.1.1	-	E	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HFNEBIIC_00227	2.89e-22	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HFNEBIIC_00228	5.6e-126	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HFNEBIIC_00229	2.73e-71	-	-	-	L	-	-	-	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
HFNEBIIC_00230	1.76e-140	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
HFNEBIIC_00231	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
HFNEBIIC_00232	1.37e-119	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
HFNEBIIC_00233	3.01e-125	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFNEBIIC_00234	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HFNEBIIC_00235	9.13e-238	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFNEBIIC_00236	4.27e-66	-	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain protein
HFNEBIIC_00237	1.88e-68	yvlD	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
HFNEBIIC_00238	3.96e-226	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFNEBIIC_00239	9.5e-200	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFNEBIIC_00240	9.42e-234	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
HFNEBIIC_00241	1.08e-215	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HFNEBIIC_00242	8.71e-176	lutC	-	-	S	ko:K00782	-	ko00000	LUD domain
HFNEBIIC_00243	0.0	lutB	-	-	C	ko:K18929	-	ko00000	4Fe-4S dicluster domain
HFNEBIIC_00244	1.12e-214	lutA	-	-	C	ko:K18928	-	ko00000	Cysteine-rich domain
HFNEBIIC_00245	9.67e-222	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HFNEBIIC_00246	1.06e-258	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HFNEBIIC_00247	4.9e-207	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	PFAM extracellular solute-binding protein, family 3
HFNEBIIC_00248	9.93e-115	ykhA	3.1.2.20	-	I	ko:K01073	-	ko00000,ko01000	Thioesterase superfamily
HFNEBIIC_00249	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HFNEBIIC_00250	3.57e-150	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
HFNEBIIC_00251	1.03e-19	-	-	-	-	-	-	-	-
HFNEBIIC_00252	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HFNEBIIC_00253	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HFNEBIIC_00254	1.84e-316	steT	-	-	E	ko:K03294	-	ko00000	amino acid
HFNEBIIC_00255	1.39e-208	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
HFNEBIIC_00256	9.5e-238	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
HFNEBIIC_00257	1.59e-217	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
HFNEBIIC_00259	1.83e-21	-	-	-	-	-	-	-	-
HFNEBIIC_00260	2.94e-261	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HFNEBIIC_00261	2.49e-187	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_00262	4.43e-183	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_00263	1.64e-264	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HFNEBIIC_00264	3.93e-45	-	-	-	-	-	-	-	-
HFNEBIIC_00265	5.35e-64	-	-	-	-	-	-	-	-
HFNEBIIC_00266	2.17e-79	-	-	-	-	-	-	-	-
HFNEBIIC_00267	7.72e-42	-	-	-	M	-	-	-	Glycosyl transferase family group 2
HFNEBIIC_00268	1.19e-195	-	-	-	M	-	-	-	Glycosyl transferase family group 2
HFNEBIIC_00269	3.52e-128	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HFNEBIIC_00270	9.38e-113	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HFNEBIIC_00271	3.6e-107	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HFNEBIIC_00272	2.46e-72	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HFNEBIIC_00273	3.05e-49	-	-	-	-	-	-	-	-
HFNEBIIC_00274	1.9e-61	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HFNEBIIC_00275	2.79e-75	XK27_06915	-	-	K	ko:K10947	-	ko00000,ko03000	transcriptional regulator PadR family
HFNEBIIC_00276	6.31e-126	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
HFNEBIIC_00277	3.76e-40	-	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
HFNEBIIC_00278	2.53e-82	-	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
HFNEBIIC_00279	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
HFNEBIIC_00280	7.68e-254	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFNEBIIC_00281	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFNEBIIC_00282	9.33e-48	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
HFNEBIIC_00283	1.92e-113	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HFNEBIIC_00284	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFNEBIIC_00285	5.87e-62	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFNEBIIC_00286	4.73e-140	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFNEBIIC_00287	2.71e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
HFNEBIIC_00288	3.41e-144	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HFNEBIIC_00289	1.64e-68	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
HFNEBIIC_00290	4.14e-232	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HFNEBIIC_00291	1.77e-74	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
HFNEBIIC_00292	4.31e-198	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFNEBIIC_00293	1.18e-173	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
HFNEBIIC_00294	0.0	ppx3	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HFNEBIIC_00295	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HFNEBIIC_00296	7.29e-219	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HFNEBIIC_00297	2.35e-244	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFNEBIIC_00298	6.03e-161	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
HFNEBIIC_00299	3.26e-130	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
HFNEBIIC_00300	1.13e-248	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HFNEBIIC_00301	1.47e-169	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFNEBIIC_00302	8.21e-287	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFNEBIIC_00303	1.48e-176	proB	2.7.2.11	-	F	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HFNEBIIC_00304	8.63e-180	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
HFNEBIIC_00305	8.87e-289	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00306	3.99e-231	ykpB	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFNEBIIC_00307	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
HFNEBIIC_00308	4.67e-147	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HFNEBIIC_00310	1.83e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HFNEBIIC_00311	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HFNEBIIC_00312	7.03e-103	-	-	-	S	ko:K19055	-	ko00000,ko01000,ko03016	Aminoacyl-tRNA editing domain
HFNEBIIC_00313	0.0	-	-	-	E	-	-	-	amino acid
HFNEBIIC_00314	0.0	ydaO	-	-	E	-	-	-	amino acid
HFNEBIIC_00315	1.53e-52	-	-	-	-	-	-	-	-
HFNEBIIC_00316	1.16e-55	-	-	-	L	ko:K07483,ko:K07497	-	ko00000	Helix-turn-helix domain
HFNEBIIC_00317	3.1e-87	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
HFNEBIIC_00318	1.11e-67	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
HFNEBIIC_00319	1.04e-114	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HFNEBIIC_00320	8.85e-164	-	-	-	F	-	-	-	NUDIX domain
HFNEBIIC_00321	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFNEBIIC_00322	3.18e-133	pncA	-	-	Q	-	-	-	Isochorismatase family
HFNEBIIC_00323	1.57e-70	-	-	-	K	-	-	-	transcriptional regulator
HFNEBIIC_00324	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	E1-E2 ATPase
HFNEBIIC_00325	2.79e-49	copZ	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	PFAM Heavy metal transport detoxification protein
HFNEBIIC_00326	1.44e-127	dpsB	-	-	P	-	-	-	Belongs to the Dps family
HFNEBIIC_00327	3.16e-144	fnr	-	-	K	ko:K21562	-	ko00000,ko03000	Transcriptional regulator, Crp Fnr family
HFNEBIIC_00333	2.61e-148	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
HFNEBIIC_00334	0.0	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
HFNEBIIC_00335	1.69e-07	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HFNEBIIC_00336	1.55e-150	-	-	-	I	-	-	-	phosphatase
HFNEBIIC_00337	8.68e-106	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HFNEBIIC_00338	5.75e-164	-	-	-	S	-	-	-	Putative threonine/serine exporter
HFNEBIIC_00339	2.54e-42	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HFNEBIIC_00340	3.16e-159	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
HFNEBIIC_00341	3.18e-209	-	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
HFNEBIIC_00342	2.1e-151	-	-	-	S	-	-	-	membrane
HFNEBIIC_00343	3.7e-139	-	-	-	S	-	-	-	VIT family
HFNEBIIC_00344	4.83e-108	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
HFNEBIIC_00345	1.39e-173	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_00346	5.46e-195	peb1A	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HFNEBIIC_00347	5.24e-143	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_00348	3.65e-141	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_00349	8.11e-282	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HFNEBIIC_00350	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFNEBIIC_00351	8.46e-77	-	-	-	-	-	-	-	-
HFNEBIIC_00352	5.98e-95	-	-	-	K	-	-	-	MerR HTH family regulatory protein
HFNEBIIC_00353	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HFNEBIIC_00354	4.39e-159	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HFNEBIIC_00355	2.64e-209	yjbO	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HFNEBIIC_00357	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFNEBIIC_00358	7.62e-132	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
HFNEBIIC_00359	5.3e-239	-	-	-	I	-	-	-	Alpha beta
HFNEBIIC_00360	0.0	qacA	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_00361	7.76e-152	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil-DNA glycosylase
HFNEBIIC_00362	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
HFNEBIIC_00363	2.41e-203	-	-	-	K	-	-	-	LysR family
HFNEBIIC_00364	0.0	citP	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
HFNEBIIC_00365	0.0	frdA	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
HFNEBIIC_00366	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HFNEBIIC_00367	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
HFNEBIIC_00368	2.9e-202	mleR	-	-	K	-	-	-	LysR family
HFNEBIIC_00369	6.76e-143	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFNEBIIC_00370	3.86e-263	adh	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Zinc-binding alcohol dehydrogenase family protein
HFNEBIIC_00371	0.0	-	-	-	L	-	-	-	PFAM plasmid pRiA4b ORF-3 family protein
HFNEBIIC_00372	1.22e-204	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
HFNEBIIC_00373	0.0	-	-	-	S	ko:K13730	ko05100,map05100	ko00000,ko00001	Uncharacterized protein conserved in bacteria (DUF2252)
HFNEBIIC_00374	2.33e-29	-	-	-	-	-	-	-	-
HFNEBIIC_00375	1.05e-254	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
HFNEBIIC_00376	5.36e-97	-	-	-	-	-	-	-	-
HFNEBIIC_00377	1.27e-290	dacA	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HFNEBIIC_00378	1.37e-178	-	-	-	V	-	-	-	Beta-lactamase enzyme family
HFNEBIIC_00379	0.0	gtfA	2.4.1.7	GH13	G	ko:K00690	ko00500,map00500	ko00000,ko00001,ko01000	Sucrose glucosyltransferase
HFNEBIIC_00380	1.09e-275	-	-	-	EGP	-	-	-	Transporter, major facilitator family protein
HFNEBIIC_00381	0.0	arcT	-	-	E	-	-	-	Dipeptidase
HFNEBIIC_00382	0.0	arcD	-	-	S	-	-	-	C4-dicarboxylate anaerobic carrier
HFNEBIIC_00383	9.03e-229	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Peroxidase
HFNEBIIC_00384	1.31e-212	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
HFNEBIIC_00385	5.89e-171	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HFNEBIIC_00386	6.16e-175	-	-	-	S	-	-	-	Conserved hypothetical protein 698
HFNEBIIC_00387	1.76e-122	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
HFNEBIIC_00388	1.26e-214	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HFNEBIIC_00389	4.46e-227	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
HFNEBIIC_00390	2.2e-292	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HFNEBIIC_00391	6.93e-83	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HFNEBIIC_00393	7.92e-69	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
HFNEBIIC_00400	8.89e-113	-	-	-	Q	-	-	-	Methyltransferase
HFNEBIIC_00401	2.8e-152	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	domain protein
HFNEBIIC_00402	9.61e-305	ktrB	-	-	P	ko:K03498	-	ko00000,ko02000	Potassium uptake protein
HFNEBIIC_00403	0.0	mycA	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
HFNEBIIC_00404	3.28e-180	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
HFNEBIIC_00405	5.54e-107	-	-	-	G	-	-	-	Glycosyl hydrolases family 8
HFNEBIIC_00406	7.27e-142	-	-	-	G	-	-	-	Glycosyl hydrolases family 8
HFNEBIIC_00407	3.37e-308	-	-	-	M	-	-	-	Glycosyl transferase
HFNEBIIC_00409	2.37e-190	-	-	-	-	-	-	-	-
HFNEBIIC_00410	3.38e-161	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HFNEBIIC_00411	9.02e-177	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HFNEBIIC_00412	7.73e-199	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HFNEBIIC_00413	2.77e-195	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HFNEBIIC_00414	5.71e-204	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HFNEBIIC_00415	9.78e-169	-	-	-	K	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C-terminal domain protein
HFNEBIIC_00417	2.33e-238	-	-	-	-	-	-	-	-
HFNEBIIC_00418	4.68e-126	-	-	-	K	-	-	-	acetyltransferase
HFNEBIIC_00419	2.62e-139	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HFNEBIIC_00420	1.71e-89	-	1.1.1.90	-	C	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Zn-dependent alcohol dehydrogenases, class III
HFNEBIIC_00421	1.65e-81	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFNEBIIC_00422	1.07e-239	-	-	-	-	-	-	-	-
HFNEBIIC_00423	4.8e-128	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFNEBIIC_00424	4.21e-232	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
HFNEBIIC_00425	0.0	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
HFNEBIIC_00427	4.34e-202	metQ1	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HFNEBIIC_00428	9.38e-115	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HFNEBIIC_00429	2.9e-157	-	-	-	O	-	-	-	Zinc-dependent metalloprotease
HFNEBIIC_00430	5.31e-108	-	-	-	L	-	-	-	Helix-turn-helix domain
HFNEBIIC_00431	5.75e-52	-	-	-	S	-	-	-	Cytochrome B5
HFNEBIIC_00433	1.12e-135	-	-	-	K	-	-	-	PFAM GCN5-related N-acetyltransferase
HFNEBIIC_00434	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFNEBIIC_00435	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HFNEBIIC_00436	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
HFNEBIIC_00437	1.22e-220	malR1	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
HFNEBIIC_00438	2.2e-273	atoB	1.1.1.88, 2.3.1.9	-	I	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HFNEBIIC_00439	0.0	malT	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
HFNEBIIC_00440	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
HFNEBIIC_00441	1.76e-154	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	beta-phosphoglucomutase
HFNEBIIC_00442	1.17e-91	-	-	-	-	-	-	-	-
HFNEBIIC_00443	3.55e-112	-	-	-	T	-	-	-	Region found in RelA / SpoT proteins
HFNEBIIC_00444	3.15e-153	dltr	-	-	K	-	-	-	response regulator
HFNEBIIC_00445	7.94e-290	sptS	-	-	T	-	-	-	Histidine kinase
HFNEBIIC_00446	2.9e-274	-	-	-	P	-	-	-	Voltage gated chloride channel
HFNEBIIC_00447	0.0	gshAB	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
HFNEBIIC_00448	2.5e-174	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
HFNEBIIC_00449	3.48e-213	-	-	-	C	-	-	-	Aldo keto reductase
HFNEBIIC_00450	0.0	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Membrane domain of glycerophosphoryl diester phosphodiesterase
HFNEBIIC_00451	6.51e-114	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
HFNEBIIC_00452	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
HFNEBIIC_00453	1.71e-238	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HFNEBIIC_00454	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HFNEBIIC_00455	2.96e-120	-	-	-	-	-	-	-	-
HFNEBIIC_00456	1.82e-122	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HFNEBIIC_00458	1.11e-16	-	-	-	E	-	-	-	amino acid
HFNEBIIC_00459	2.53e-17	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
HFNEBIIC_00460	6.53e-96	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
HFNEBIIC_00461	8.53e-95	-	-	-	-	-	-	-	-
HFNEBIIC_00462	0.0	tagE6	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HFNEBIIC_00463	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Poly(Glycerol-phosphate) alpha-glucosyltransferase
HFNEBIIC_00464	0.0	sdrF	-	-	M	ko:K14194	ko05150,map05150	ko00000,ko00001	protein which possibly mediates interactions of S.aureus with components of the extracellular matrix of higher eukaryotes
HFNEBIIC_00465	0.0	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HFNEBIIC_00466	0.0	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
HFNEBIIC_00467	7.28e-59	-	-	-	V	-	-	-	DNA restriction-modification system
HFNEBIIC_00468	2.05e-30	-	-	-	V	-	-	-	DNA restriction-modification system
HFNEBIIC_00469	1.5e-81	-	-	-	V	-	-	-	DNA restriction-modification system
HFNEBIIC_00470	5.16e-289	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	Major Facilitator Superfamily
HFNEBIIC_00471	1.2e-205	-	-	-	J	-	-	-	Methyltransferase
HFNEBIIC_00472	2.63e-124	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
HFNEBIIC_00473	1.14e-64	-	-	-	S	-	-	-	ParE toxin of type II toxin-antitoxin system, parDE
HFNEBIIC_00474	2.74e-50	-	-	-	D	-	-	-	Antitoxin component of a toxin-antitoxin (TA) module
HFNEBIIC_00475	1.21e-251	-	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_00476	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HFNEBIIC_00477	1.04e-69	-	-	-	M	-	-	-	Lysin motif
HFNEBIIC_00478	1.55e-152	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
HFNEBIIC_00479	1.49e-274	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
HFNEBIIC_00480	9.51e-317	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
HFNEBIIC_00481	1.6e-54	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HFNEBIIC_00482	1.06e-297	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
HFNEBIIC_00483	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_00484	9.48e-130	msrA	1.8.4.11	-	C	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFNEBIIC_00485	1.08e-67	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HFNEBIIC_00486	4.06e-105	-	-	-	V	-	-	-	Restriction endonuclease
HFNEBIIC_00487	5.28e-265	-	-	-	L	-	-	-	DNA restriction-modification system
HFNEBIIC_00490	0.0	-	-	-	I	-	-	-	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFNEBIIC_00491	4.82e-55	-	-	-	S	ko:K09790	-	ko00000	Protein of unknown function (DUF454)
HFNEBIIC_00492	9.59e-96	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
HFNEBIIC_00493	5.93e-149	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
HFNEBIIC_00494	5.51e-205	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HFNEBIIC_00495	4.69e-25	-	-	-	-	-	-	-	-
HFNEBIIC_00496	8e-117	ntd	2.4.2.6	-	F	ko:K08728	ko00240,map00240	ko00000,ko00001,ko01000	Nucleoside
HFNEBIIC_00498	1.31e-243	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HFNEBIIC_00499	4.41e-289	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
HFNEBIIC_00500	1.45e-181	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HFNEBIIC_00501	0.0	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HFNEBIIC_00502	9.04e-317	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HFNEBIIC_00503	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HFNEBIIC_00504	1.43e-47	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HFNEBIIC_00505	2.49e-182	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Serine aminopeptidase, S33
HFNEBIIC_00506	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HFNEBIIC_00507	7.73e-109	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HFNEBIIC_00508	1.59e-135	-	-	-	-	-	-	-	-
HFNEBIIC_00509	7.51e-174	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HFNEBIIC_00510	2.79e-228	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
HFNEBIIC_00511	2.18e-103	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
HFNEBIIC_00512	2.16e-114	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HFNEBIIC_00513	2.92e-98	XK27_04775	-	-	S	ko:K09155	-	ko00000	PAS domain
HFNEBIIC_00514	7.18e-131	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HFNEBIIC_00515	5.56e-215	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
HFNEBIIC_00516	1.25e-211	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFNEBIIC_00517	4.1e-87	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HFNEBIIC_00518	0.0	fucP	-	-	G	ko:K02429	-	ko00000,ko02000	Major Facilitator Superfamily
HFNEBIIC_00519	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_00520	0.0	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
HFNEBIIC_00521	1.33e-47	-	-	-	-	-	-	-	-
HFNEBIIC_00522	1.86e-12	-	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HFNEBIIC_00523	2.08e-219	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HFNEBIIC_00524	1.53e-188	epsB	-	-	M	-	-	-	biosynthesis protein
HFNEBIIC_00525	8.04e-155	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
HFNEBIIC_00526	8.58e-140	rfbP	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
HFNEBIIC_00527	2.93e-199	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFNEBIIC_00528	5.58e-140	rfbC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HFNEBIIC_00529	5.25e-260	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HFNEBIIC_00530	1.75e-111	cps3J	-	-	M	-	-	-	Domain of unknown function (DUF4422)
HFNEBIIC_00531	4.2e-39	-	-	-	M	-	-	-	Glycosyltransferase family 92
HFNEBIIC_00532	8.2e-45	-	-	GT2	S	ko:K12990	ko02024,ko02025,map02024,map02025	ko00000,ko00001,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HFNEBIIC_00533	0.000398	-	-	-	S	-	-	-	EpsG family
HFNEBIIC_00534	8.35e-59	-	-	GT2	M	ko:K12997	-	ko00000,ko01000,ko01003,ko01005	COG0463, glycosyltransferases involved in cell wall biogenesis
HFNEBIIC_00535	8.52e-144	-	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HFNEBIIC_00536	3.8e-64	-	-	GT2	S	ko:K12990	ko02024,ko02025,map02024,map02025	ko00000,ko00001,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HFNEBIIC_00537	1.03e-60	-	-	-	S	-	-	-	Acyltransferase family
HFNEBIIC_00538	2.78e-275	glf	5.4.99.9	-	M	ko:K01854	ko00052,ko00520,map00052,map00520	ko00000,ko00001,ko01000	UDP-galactopyranose mutase
HFNEBIIC_00539	2.43e-200	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HFNEBIIC_00540	0.0	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_00541	5.44e-79	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_00545	8.06e-54	-	-	-	L	ko:K07491	-	ko00000	PFAM transposase IS200-family protein
HFNEBIIC_00546	1.15e-34	-	-	-	-	-	-	-	-
HFNEBIIC_00547	1.67e-56	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
HFNEBIIC_00548	1.21e-124	-	-	-	-	-	-	-	-
HFNEBIIC_00549	3.86e-06	-	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
HFNEBIIC_00550	1.02e-72	-	1.6.5.2	-	GM	ko:K19267	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NAD(P)H-binding
HFNEBIIC_00553	1.94e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF4065)
HFNEBIIC_00554	7.76e-113	doc	-	-	-	ko:K07341	-	ko00000,ko02048	-
HFNEBIIC_00555	1.21e-14	-	-	-	-	-	-	-	-
HFNEBIIC_00558	9.27e-220	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine S-methyltransferase
HFNEBIIC_00559	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HFNEBIIC_00561	0.0	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
HFNEBIIC_00562	7.57e-114	-	-	-	-	-	-	-	-
HFNEBIIC_00563	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFNEBIIC_00564	1.89e-35	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
HFNEBIIC_00565	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
HFNEBIIC_00566	0.0	pepD4	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HFNEBIIC_00567	0.0	-	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Thioredoxin domain
HFNEBIIC_00568	5.4e-135	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	Peroxiredoxin
HFNEBIIC_00569	2.76e-192	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
HFNEBIIC_00570	2.6e-156	sdhB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
HFNEBIIC_00573	1.14e-231	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
HFNEBIIC_00574	2.16e-44	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
HFNEBIIC_00575	1.66e-246	flp	-	-	V	-	-	-	Beta-lactamase
HFNEBIIC_00576	3.54e-122	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HFNEBIIC_00577	8.07e-139	-	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
HFNEBIIC_00578	9.22e-140	-	-	-	S	-	-	-	GyrI-like small molecule binding domain
HFNEBIIC_00579	2.57e-141	-	-	-	S	-	-	-	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
HFNEBIIC_00580	9.14e-66	azlD	-	-	E	-	-	-	Branched-chain amino acid transport
HFNEBIIC_00581	8.93e-153	azlC	-	-	E	-	-	-	azaleucine resistance protein AzlC
HFNEBIIC_00582	0.0	-	-	-	K	-	-	-	Aminotransferase class I and II
HFNEBIIC_00583	4.35e-239	-	-	-	S	-	-	-	amidohydrolase
HFNEBIIC_00584	6.98e-137	-	-	-	L	-	-	-	Helix-turn-helix domain
HFNEBIIC_00585	2.93e-125	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HFNEBIIC_00586	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HFNEBIIC_00587	1.55e-294	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	Gluconate
HFNEBIIC_00588	3.78e-230	-	-	-	K	ko:K02525	-	ko00000,ko03000	Transcriptional regulator, LacI family
HFNEBIIC_00589	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HFNEBIIC_00590	7.38e-121	-	-	-	-	-	-	-	-
HFNEBIIC_00591	3.61e-34	-	-	-	-	-	-	-	-
HFNEBIIC_00592	3.7e-79	asp1	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HFNEBIIC_00593	2.87e-112	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
HFNEBIIC_00595	3.72e-65	-	-	-	-	-	-	-	-
HFNEBIIC_00596	1.01e-86	-	-	-	S	-	-	-	Belongs to the HesB IscA family
HFNEBIIC_00597	1.81e-222	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
HFNEBIIC_00598	1.02e-103	-	-	-	F	-	-	-	NUDIX domain
HFNEBIIC_00599	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HFNEBIIC_00600	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HFNEBIIC_00601	3.52e-135	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HFNEBIIC_00602	3.08e-209	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
HFNEBIIC_00603	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFNEBIIC_00604	8.77e-204	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
HFNEBIIC_00605	5.63e-178	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFNEBIIC_00606	5.96e-206	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HFNEBIIC_00607	1.33e-47	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
HFNEBIIC_00608	1.65e-140	ypmS	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2140)
HFNEBIIC_00609	8.88e-217	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
HFNEBIIC_00610	1.83e-195	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
HFNEBIIC_00611	1.23e-142	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
HFNEBIIC_00612	1.95e-118	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFNEBIIC_00613	8.18e-244	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HFNEBIIC_00614	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_00615	1.16e-285	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HFNEBIIC_00616	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_00617	9.99e-44	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
HFNEBIIC_00618	2.92e-230	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic
HFNEBIIC_00619	4.37e-39	-	-	-	-	-	-	-	-
HFNEBIIC_00620	2.51e-217	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
HFNEBIIC_00622	2.15e-75	-	-	-	-	-	-	-	-
HFNEBIIC_00623	3.74e-265	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
HFNEBIIC_00624	1.1e-279	yojA	-	-	EG	ko:K03299	-	ko00000,ko02000	GntP family permease
HFNEBIIC_00625	2.65e-102	-	-	-	KT	ko:K02647	-	ko00000,ko03000	Putative sugar diacid recognition
HFNEBIIC_00626	4.47e-255	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFNEBIIC_00627	5.91e-279	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00628	1.56e-181	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HFNEBIIC_00629	1.32e-222	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFNEBIIC_00630	9.46e-283	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HFNEBIIC_00631	3.78e-111	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HFNEBIIC_00632	5.41e-310	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HFNEBIIC_00633	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HFNEBIIC_00634	2.6e-233	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HFNEBIIC_00635	1.66e-220	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFNEBIIC_00636	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HFNEBIIC_00637	6.34e-156	-	-	-	S	-	-	-	repeat protein
HFNEBIIC_00638	5.71e-159	pgm6	-	-	G	-	-	-	phosphoglycerate mutase
HFNEBIIC_00639	6.17e-286	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HFNEBIIC_00640	5.58e-76	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
HFNEBIIC_00641	1.1e-278	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HFNEBIIC_00642	1.62e-160	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFNEBIIC_00643	1.19e-25	-	-	-	-	-	-	-	-
HFNEBIIC_00644	1.44e-128	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
HFNEBIIC_00645	5.69e-44	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HFNEBIIC_00646	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFNEBIIC_00647	8.87e-101	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA domain protein
HFNEBIIC_00648	2.5e-188	ylmH	-	-	S	-	-	-	S4 domain protein
HFNEBIIC_00649	1.11e-54	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	YGGT family
HFNEBIIC_00650	1.11e-92	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HFNEBIIC_00651	8.44e-284	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFNEBIIC_00652	0.0	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HFNEBIIC_00653	5.77e-184	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HFNEBIIC_00654	1.63e-257	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFNEBIIC_00655	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFNEBIIC_00656	7.73e-230	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFNEBIIC_00657	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HFNEBIIC_00658	9.94e-73	ftsL	-	-	D	-	-	-	Cell division protein FtsL
HFNEBIIC_00659	6.02e-220	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HFNEBIIC_00660	1.5e-101	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
HFNEBIIC_00661	4.5e-73	-	-	-	-	-	-	-	-
HFNEBIIC_00662	4.47e-16	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
HFNEBIIC_00663	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HFNEBIIC_00664	1.53e-123	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HFNEBIIC_00665	6.7e-205	rrmA	2.1.1.187	-	H	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase
HFNEBIIC_00666	3.12e-250	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
HFNEBIIC_00668	2.8e-81	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_00669	7.34e-309	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_00671	2.21e-87	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_00672	1.88e-196	-	-	-	EG	-	-	-	EamA-like transporter family
HFNEBIIC_00673	9.45e-152	-	-	-	L	-	-	-	Integrase
HFNEBIIC_00674	6.66e-200	rssA	-	-	S	-	-	-	Phospholipase, patatin family
HFNEBIIC_00675	0.0	sacB	2.4.1.10, 2.4.1.9	GH68	M	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	Levansucrase/Invertase
HFNEBIIC_00676	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_00677	3.2e-246	-	-	-	S	-	-	-	Helix-turn-helix domain
HFNEBIIC_00678	6e-130	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HFNEBIIC_00679	1.49e-164	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HFNEBIIC_00680	5.49e-135	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFNEBIIC_00681	9.25e-176	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HFNEBIIC_00682	1.23e-84	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HFNEBIIC_00683	1.93e-210	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
HFNEBIIC_00684	2.27e-216	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
HFNEBIIC_00685	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
HFNEBIIC_00686	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
HFNEBIIC_00687	3.79e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
HFNEBIIC_00688	2.73e-302	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HFNEBIIC_00689	2.07e-198	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFNEBIIC_00690	1.27e-159	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
HFNEBIIC_00691	7.19e-280	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_00692	1.21e-264	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HFNEBIIC_00693	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HFNEBIIC_00694	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
HFNEBIIC_00695	2.14e-234	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
HFNEBIIC_00696	2.5e-188	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
HFNEBIIC_00697	1.8e-217	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFNEBIIC_00698	1.66e-77	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
HFNEBIIC_00699	4.45e-109	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HFNEBIIC_00700	1.76e-232	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
HFNEBIIC_00701	2.54e-219	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HFNEBIIC_00702	2.57e-111	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
HFNEBIIC_00703	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
HFNEBIIC_00704	1.2e-302	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
HFNEBIIC_00705	1.07e-237	cbh	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HFNEBIIC_00706	2.34e-92	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
HFNEBIIC_00707	1e-31	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
HFNEBIIC_00708	0.0	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HFNEBIIC_00709	2.57e-169	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_00710	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HFNEBIIC_00711	2.55e-212	-	-	-	G	-	-	-	Phosphotransferase enzyme family
HFNEBIIC_00712	3.12e-100	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HFNEBIIC_00713	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFNEBIIC_00714	1.17e-69	-	-	-	-	-	-	-	-
HFNEBIIC_00715	1.86e-162	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HFNEBIIC_00716	9.38e-229	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
HFNEBIIC_00717	3.36e-77	-	-	-	-	-	-	-	-
HFNEBIIC_00718	7.92e-221	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HFNEBIIC_00720	1.44e-254	-	-	-	C	-	-	-	Belongs to the LDH2 MDH2 oxidoreductase family
HFNEBIIC_00721	0.0	pepD3	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HFNEBIIC_00722	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HFNEBIIC_00723	2.2e-273	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HFNEBIIC_00724	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
HFNEBIIC_00725	3.69e-114	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFNEBIIC_00726	5.35e-246	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HFNEBIIC_00727	3.09e-85	-	-	-	-	-	-	-	-
HFNEBIIC_00728	8.98e-225	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
HFNEBIIC_00729	3.58e-208	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFNEBIIC_00730	1.38e-77	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFNEBIIC_00731	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HFNEBIIC_00732	2.67e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
HFNEBIIC_00733	5.93e-60	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
HFNEBIIC_00734	4.81e-274	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
HFNEBIIC_00735	7.43e-107	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
HFNEBIIC_00736	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFNEBIIC_00737	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HFNEBIIC_00738	8.1e-299	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
HFNEBIIC_00739	5.83e-178	cdsA	2.7.7.41	-	I	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
HFNEBIIC_00740	1.29e-182	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFNEBIIC_00741	3.48e-122	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HFNEBIIC_00742	1.72e-166	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
HFNEBIIC_00743	1.82e-196	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFNEBIIC_00744	2.91e-183	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
HFNEBIIC_00745	1.62e-230	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFNEBIIC_00746	9.65e-65	yazA	-	-	L	ko:K07461	-	ko00000	GIY-YIG catalytic domain protein
HFNEBIIC_00747	1.14e-179	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
HFNEBIIC_00748	2.62e-152	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
HFNEBIIC_00749	1.6e-40	XK26_06720	-	-	S	ko:K09976	-	ko00000	Uncharacterised protein family (UPF0154)
HFNEBIIC_00750	2.7e-47	ynzC	-	-	S	-	-	-	UPF0291 protein
HFNEBIIC_00751	2.52e-148	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFNEBIIC_00752	1.25e-264	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
HFNEBIIC_00753	2.82e-161	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFNEBIIC_00754	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_00756	1.08e-135	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HFNEBIIC_00757	7.72e-19	-	-	-	S	-	-	-	COG5546 Small integral membrane protein
HFNEBIIC_00763	3.73e-90	-	-	-	D	-	-	-	domain protein
HFNEBIIC_00767	3.6e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF806)
HFNEBIIC_00771	1.59e-97	-	-	-	S	ko:K06904	-	ko00000	Phage capsid family
HFNEBIIC_00772	7.45e-95	-	-	-	S	-	-	-	Phage portal protein
HFNEBIIC_00773	3.33e-201	-	-	-	S	-	-	-	Phage Terminase
HFNEBIIC_00774	3.51e-19	-	-	-	L	-	-	-	Phage terminase, small subunit
HFNEBIIC_00780	3.28e-39	-	-	-	S	ko:K06919	-	ko00000	D5 N terminal like
HFNEBIIC_00788	3.88e-50	int2	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_00789	1.02e-198	endA	-	-	V	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
HFNEBIIC_00790	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HFNEBIIC_00792	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFNEBIIC_00793	7.36e-291	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
HFNEBIIC_00794	3.25e-155	-	-	-	S	-	-	-	SNARE associated Golgi protein
HFNEBIIC_00795	0.0	uvrA2	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC, A subunit
HFNEBIIC_00796	2.56e-72	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFNEBIIC_00797	4.18e-75	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFNEBIIC_00798	1.96e-89	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HFNEBIIC_00799	5.2e-186	-	-	-	S	-	-	-	DUF218 domain
HFNEBIIC_00800	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	ABC1 family
HFNEBIIC_00801	1.84e-316	yhdP	-	-	S	-	-	-	Transporter associated domain
HFNEBIIC_00802	1.68e-98	atkY	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Copper transport repressor CopY TcrY
HFNEBIIC_00803	1.01e-309	-	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HFNEBIIC_00804	3.87e-97	-	-	-	S	-	-	-	UPF0756 membrane protein
HFNEBIIC_00805	1.33e-102	-	-	-	S	-	-	-	Cupin domain
HFNEBIIC_00806	5.42e-105	-	-	-	C	-	-	-	Flavodoxin
HFNEBIIC_00807	5.14e-49	rlrB	-	-	K	-	-	-	LysR substrate binding domain protein
HFNEBIIC_00808	1.15e-129	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HFNEBIIC_00809	1.62e-111	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_00810	1.16e-86	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_00811	1.23e-75	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_00813	2.16e-45	-	-	-	M	-	-	-	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFNEBIIC_00814	1.26e-127	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_00815	8.59e-69	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
HFNEBIIC_00816	1.14e-231	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
HFNEBIIC_00817	1.14e-231	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
HFNEBIIC_00818	8.59e-69	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
HFNEBIIC_00819	2.48e-57	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFNEBIIC_00820	1.17e-213	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HFNEBIIC_00821	7.35e-291	mdtG2	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
HFNEBIIC_00822	3.29e-166	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HFNEBIIC_00823	2.16e-44	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
HFNEBIIC_00824	1.14e-231	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
HFNEBIIC_00828	4.61e-27	-	-	-	L	-	-	-	nuclease
HFNEBIIC_00830	6.6e-75	-	-	-	K	-	-	-	Peptidase S24-like
HFNEBIIC_00831	8.47e-31	-	-	-	K	-	-	-	Protein of unknown function (DUF739)
HFNEBIIC_00833	1.66e-27	-	-	-	-	-	-	-	-
HFNEBIIC_00841	5.38e-146	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
HFNEBIIC_00842	1.14e-172	pi112	-	-	L	-	-	-	PDDEXK-like domain of unknown function (DUF3799)
HFNEBIIC_00843	3.33e-06	-	-	-	L	-	-	-	HNH nucleases
HFNEBIIC_00844	1.44e-89	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
HFNEBIIC_00845	8.7e-65	-	-	-	-	-	-	-	-
HFNEBIIC_00847	2.76e-247	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_00848	2.71e-156	-	-	-	V	-	-	-	site-specific DNA-methyltransferase (adenine-specific) activity
HFNEBIIC_00850	5.54e-34	-	-	-	-	-	-	-	-
HFNEBIIC_00852	1.4e-103	-	-	-	Q	-	-	-	DNA (cytosine-5-)-methyltransferase activity
HFNEBIIC_00856	1.74e-27	-	-	-	-	-	-	-	-
HFNEBIIC_00857	3.49e-81	rusA	-	-	L	-	-	-	Endodeoxyribonuclease RusA
HFNEBIIC_00865	1.89e-77	-	-	-	S	-	-	-	HicB_like antitoxin of bacterial toxin-antitoxin system
HFNEBIIC_00866	1.79e-69	-	-	-	L	ko:K07474	-	ko00000	Terminase small subunit
HFNEBIIC_00867	6.33e-214	-	-	-	S	-	-	-	Terminase-like family
HFNEBIIC_00868	1.22e-143	-	-	-	S	-	-	-	Phage portal protein, SPP1 Gp6-like
HFNEBIIC_00869	1.42e-08	-	-	-	S	-	-	-	head morphogenesis protein, SPP1 gp7 family
HFNEBIIC_00870	4.34e-19	-	-	-	S	-	-	-	Domain of unknown function (DUF4355)
HFNEBIIC_00871	3.72e-165	gpG	-	-	-	-	-	-	-
HFNEBIIC_00874	1.43e-24	-	-	-	-	-	-	-	-
HFNEBIIC_00879	0.0	-	-	-	D	-	-	-	domain protein
HFNEBIIC_00880	5.22e-128	-	-	-	S	-	-	-	Phage tail protein
HFNEBIIC_00881	1.5e-236	-	-	-	S	-	-	-	Peptidase family M23
HFNEBIIC_00884	3.87e-136	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HFNEBIIC_00885	1.16e-40	-	-	-	-	-	-	-	-
HFNEBIIC_00886	5.12e-69	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
HFNEBIIC_00887	5.63e-225	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HFNEBIIC_00888	2.91e-24	-	-	-	-	-	-	-	-
HFNEBIIC_00889	8.61e-89	-	-	-	-	-	-	-	-
HFNEBIIC_00890	8.28e-73	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFNEBIIC_00891	1.25e-118	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
HFNEBIIC_00892	1.94e-135	folE	2.7.6.3, 3.5.4.16	-	F	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase 1
HFNEBIIC_00893	2.61e-281	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HFNEBIIC_00894	7.01e-135	folQ	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Ham1 family
HFNEBIIC_00895	1.86e-267	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	dihydropteroate synthase
HFNEBIIC_00896	1.09e-59	-	-	-	-	-	-	-	-
HFNEBIIC_00897	7.09e-53	-	-	-	-	-	-	-	-
HFNEBIIC_00899	8.18e-215	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HFNEBIIC_00900	7.18e-193	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HFNEBIIC_00901	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
HFNEBIIC_00902	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HFNEBIIC_00903	2.42e-64	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
HFNEBIIC_00904	1.11e-283	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	Ser Thr phosphatase family protein
HFNEBIIC_00905	0.0	yhaN	-	-	L	-	-	-	AAA domain
HFNEBIIC_00906	4.08e-176	prsA	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HFNEBIIC_00908	8.62e-102	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	histidine triad
HFNEBIIC_00909	4.66e-176	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_00910	7.75e-278	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HFNEBIIC_00911	7.53e-157	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HFNEBIIC_00912	4.37e-23	-	-	-	S	-	-	-	YSIRK type signal peptide
HFNEBIIC_00913	1.79e-18	-	2.1.1.72, 3.1.21.3	AA10,CBM73	M	ko:K01154,ko:K02014,ko:K03933,ko:K07316	-	ko00000,ko01000,ko02000,ko02048	domain protein
HFNEBIIC_00914	5.11e-17	-	2.1.1.72, 3.1.21.3	AA10,CBM73	M	ko:K01154,ko:K02014,ko:K03933,ko:K07316	-	ko00000,ko01000,ko02000,ko02048	domain protein
HFNEBIIC_00915	6.19e-74	-	2.1.1.72, 3.1.21.3	AA10,CBM73	M	ko:K01154,ko:K02014,ko:K03933,ko:K07316	-	ko00000,ko01000,ko02000,ko02048	domain protein
HFNEBIIC_00916	1.59e-14	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
HFNEBIIC_00917	5.37e-74	-	-	-	S	-	-	-	Small secreted protein
HFNEBIIC_00918	1.64e-72	ytpP	-	-	CO	-	-	-	Thioredoxin
HFNEBIIC_00919	1.63e-152	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HFNEBIIC_00920	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
HFNEBIIC_00921	4.56e-154	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
HFNEBIIC_00922	1.61e-93	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
HFNEBIIC_00923	2.26e-21	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
HFNEBIIC_00924	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFNEBIIC_00925	5.3e-202	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HFNEBIIC_00926	5.43e-125	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HFNEBIIC_00927	2.82e-105	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFNEBIIC_00928	2.22e-297	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	replication initiation and membrane attachment
HFNEBIIC_00929	8.6e-222	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
HFNEBIIC_00930	1.07e-110	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HFNEBIIC_00931	1.82e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
HFNEBIIC_00932	5.46e-74	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFNEBIIC_00933	2.72e-39	-	-	-	-	-	-	-	-
HFNEBIIC_00934	1.81e-41	-	-	-	-	-	-	-	-
HFNEBIIC_00935	7.29e-60	-	-	-	-	-	-	-	-
HFNEBIIC_00936	4.03e-98	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
HFNEBIIC_00937	4.32e-217	-	-	-	S	-	-	-	Protein of unknown function DUF262
HFNEBIIC_00938	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
HFNEBIIC_00939	7.09e-112	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HFNEBIIC_00940	2.2e-225	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_00941	3.14e-43	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Restriction endonuclease S subunits
HFNEBIIC_00942	7.81e-77	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HFNEBIIC_00943	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
HFNEBIIC_00944	5.9e-46	higA	-	-	K	ko:K21498	-	ko00000,ko02048	addiction module antidote protein HigA
HFNEBIIC_00945	0.0	-	-	-	L	-	-	-	PLD-like domain
HFNEBIIC_00947	5.44e-230	rihA	-	-	F	ko:K01250	-	ko00000,ko01000	Inosine-uridine preferring nucleoside hydrolase
HFNEBIIC_00948	8.53e-228	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFNEBIIC_00949	6.55e-122	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
HFNEBIIC_00950	1.59e-287	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HFNEBIIC_00951	1.84e-100	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HFNEBIIC_00952	6.06e-145	-	-	-	T	ko:K10716	-	ko00000,ko02000	Ion transport 2 domain protein
HFNEBIIC_00953	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
HFNEBIIC_00954	4.18e-263	-	-	-	G	-	-	-	Transporter, major facilitator family protein
HFNEBIIC_00955	1.87e-137	yvrI	-	-	K	ko:K03091,ko:K03093	-	ko00000,ko03021	sigma factor activity
HFNEBIIC_00956	5.97e-79	yuxO	-	-	Q	-	-	-	Thioesterase superfamily
HFNEBIIC_00957	1.16e-199	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFNEBIIC_00958	0.0	menE	6.2.1.26	-	H	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HFNEBIIC_00959	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
HFNEBIIC_00960	2.84e-42	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA domain
HFNEBIIC_00961	1.56e-184	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
HFNEBIIC_00962	5.55e-304	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
HFNEBIIC_00963	4.13e-295	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFNEBIIC_00964	3.05e-104	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
HFNEBIIC_00965	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
HFNEBIIC_00966	9.71e-76	-	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HFNEBIIC_00967	2.61e-203	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix
HFNEBIIC_00968	3.88e-130	nreC	-	-	K	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	PFAM regulatory protein LuxR
HFNEBIIC_00969	1.43e-51	-	-	-	S	-	-	-	Cytochrome B5
HFNEBIIC_00970	3.3e-198	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
HFNEBIIC_00971	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
HFNEBIIC_00972	1.54e-191	-	-	-	O	-	-	-	Band 7 protein
HFNEBIIC_00973	2.85e-61	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	LytS YhcK-type transmembrane receptor domain protein
HFNEBIIC_00974	1.2e-118	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	LytS YhcK-type transmembrane receptor domain protein
HFNEBIIC_00975	5.94e-160	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HFNEBIIC_00976	1.73e-215	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
HFNEBIIC_00977	7.8e-238	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding protein-like domain
HFNEBIIC_00978	0.0	melA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
HFNEBIIC_00979	3.2e-137	-	-	-	L	-	-	-	Transposase
HFNEBIIC_00980	2.33e-151	-	-	-	L	-	-	-	Transposase
HFNEBIIC_00981	2.78e-118	-	-	-	S	ko:K08996	-	ko00000	Protein of unknown function (DUF1440)
HFNEBIIC_00982	3.63e-247	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HFNEBIIC_00983	1.13e-271	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
HFNEBIIC_00984	5.73e-216	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
HFNEBIIC_00985	1.16e-216	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
HFNEBIIC_00986	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
HFNEBIIC_00987	4.69e-115	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
HFNEBIIC_00988	7.96e-158	dnaD	-	-	L	ko:K02086	-	ko00000	DnaD domain protein
HFNEBIIC_00989	2.32e-206	-	-	-	EG	-	-	-	EamA-like transporter family
HFNEBIIC_00990	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
HFNEBIIC_00991	1.36e-150	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HFNEBIIC_00992	4.8e-130	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
HFNEBIIC_00993	3.25e-72	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HFNEBIIC_00994	1.62e-106	-	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
HFNEBIIC_00995	5.93e-283	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
HFNEBIIC_00996	1.55e-91	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HI
HFNEBIIC_00997	2.58e-85	esbA	-	-	S	-	-	-	Family of unknown function (DUF5322)
HFNEBIIC_00998	1.26e-96	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFNEBIIC_00999	4.61e-221	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HFNEBIIC_01000	1.3e-263	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarA family
HFNEBIIC_01001	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HFNEBIIC_01002	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
HFNEBIIC_01003	5.95e-20	-	-	-	H	-	-	-	RibD C-terminal domain
HFNEBIIC_01004	3.83e-139	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HFNEBIIC_01005	4e-272	-	-	-	T	-	-	-	GHKL domain
HFNEBIIC_01006	1.16e-115	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HFNEBIIC_01007	6.36e-21	-	-	-	P	-	-	-	nitric oxide dioxygenase activity
HFNEBIIC_01008	7.52e-83	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
HFNEBIIC_01009	9.83e-70	-	-	-	S	-	-	-	Alpha beta hydrolase
HFNEBIIC_01010	1.39e-69	-	-	-	S	-	-	-	Alpha beta hydrolase
HFNEBIIC_01011	2.82e-194	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
HFNEBIIC_01012	1.65e-219	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HFNEBIIC_01013	5.88e-214	ypuA	-	-	S	-	-	-	Protein of unknown function (DUF1002)
HFNEBIIC_01014	4.01e-235	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase, type I
HFNEBIIC_01015	1.22e-71	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01016	1.72e-51	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01017	1.69e-133	akr5f	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
HFNEBIIC_01018	4.63e-55	akr5f	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
HFNEBIIC_01019	8.18e-129	qorB	1.6.5.2	-	GM	ko:K19267	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NmrA-like family
HFNEBIIC_01020	6.31e-79	-	-	-	-	-	-	-	-
HFNEBIIC_01021	4.69e-165	-	-	-	F	-	-	-	glutamine amidotransferase
HFNEBIIC_01022	1.69e-177	-	-	-	T	-	-	-	EAL domain
HFNEBIIC_01023	1.03e-315	yijG	-	GT2	M	ko:K11936	ko02026,map02026	ko00000,ko00001,ko01000,ko01003,ko02000	Glycosyl transferase
HFNEBIIC_01024	1.36e-106	-	-	-	-	-	-	-	-
HFNEBIIC_01025	7.13e-247	-	2.7.7.65	-	T	ko:K02488	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko00002,ko01000,ko02022	GGDEF domain
HFNEBIIC_01026	2.81e-155	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
HFNEBIIC_01027	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
HFNEBIIC_01028	3.51e-253	asnA	6.3.1.1	-	F	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
HFNEBIIC_01029	2.25e-24	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HFNEBIIC_01030	9.23e-52	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HFNEBIIC_01031	7.58e-63	ywnA	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01032	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
HFNEBIIC_01033	2.06e-145	-	-	-	GM	-	-	-	NAD dependent epimerase dehydratase family protein
HFNEBIIC_01034	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
HFNEBIIC_01035	2.65e-269	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HFNEBIIC_01036	8.33e-294	-	-	-	-	-	-	-	-
HFNEBIIC_01037	2.17e-107	-	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HFNEBIIC_01038	2.63e-137	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
HFNEBIIC_01039	1.07e-66	ydeP	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HFNEBIIC_01040	1.11e-156	-	-	-	GM	-	-	-	NmrA-like family
HFNEBIIC_01041	2.88e-96	-	-	-	S	ko:K02348	-	ko00000	Gnat family
HFNEBIIC_01042	2.22e-50	-	-	-	S	-	-	-	Cytochrome B5
HFNEBIIC_01044	8.88e-20	-	-	-	S	-	-	-	Cytochrome B5
HFNEBIIC_01045	1.02e-280	-	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
HFNEBIIC_01047	8.95e-20	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFNEBIIC_01048	9.04e-152	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFNEBIIC_01049	4.67e-313	-	-	-	E	ko:K03294	-	ko00000	amino acid
HFNEBIIC_01050	5.71e-164	npp	-	-	S	-	-	-	type I phosphodiesterase nucleotide pyrophosphatase
HFNEBIIC_01051	1.09e-63	npp	-	-	S	-	-	-	type I phosphodiesterase nucleotide pyrophosphatase
HFNEBIIC_01052	2.44e-271	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	Vacuole effluxer Atg22 like
HFNEBIIC_01054	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFNEBIIC_01055	4.17e-69	-	-	-	-	-	-	-	-
HFNEBIIC_01056	0.0	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HFNEBIIC_01057	7.01e-244	-	-	-	E	-	-	-	Zinc-binding dehydrogenase
HFNEBIIC_01058	2.52e-111	-	-	-	K	-	-	-	transcriptional regulator (TetR family)
HFNEBIIC_01059	9.09e-223	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HFNEBIIC_01060	2.37e-152	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01061	0.0	yhcA	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01062	1.61e-48	-	-	-	-	-	-	-	-
HFNEBIIC_01063	2.02e-66	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
HFNEBIIC_01064	0.0	-	3.2.1.17	CBM50	NU	ko:K01185,ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HFNEBIIC_01065	6.54e-222	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	Transcriptional regulator, LacI family
HFNEBIIC_01066	2.6e-33	-	-	-	-	-	-	-	-
HFNEBIIC_01067	4.19e-146	-	-	-	-	-	-	-	-
HFNEBIIC_01068	7.09e-273	yttB	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_01069	1.96e-311	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
HFNEBIIC_01070	1.41e-88	-	-	-	-	-	-	-	-
HFNEBIIC_01071	4.13e-140	nnrE	5.1.99.6	-	H	ko:K17759	-	ko00000,ko01000	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
HFNEBIIC_01072	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HFNEBIIC_01073	8.11e-159	-	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
HFNEBIIC_01075	1.46e-126	-	-	-	-	-	-	-	-
HFNEBIIC_01076	1.55e-274	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HFNEBIIC_01077	1.72e-170	-	-	-	S	-	-	-	Alpha beta hydrolase
HFNEBIIC_01078	2.34e-263	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	dehydrogenase
HFNEBIIC_01079	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HFNEBIIC_01080	1.7e-54	-	-	-	-	-	-	-	-
HFNEBIIC_01081	9.5e-162	pgm3	-	-	G	-	-	-	phosphoglycerate mutase family
HFNEBIIC_01082	1.14e-59	-	-	-	S	-	-	-	C4-dicarboxylate anaerobic carrier
HFNEBIIC_01083	8.86e-317	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
HFNEBIIC_01084	4.88e-301	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
HFNEBIIC_01085	0.0	pepD1	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HFNEBIIC_01086	3.34e-215	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HFNEBIIC_01087	2.09e-214	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HFNEBIIC_01088	1.08e-168	yceF	-	-	P	ko:K05794	-	ko00000	membrane
HFNEBIIC_01089	3.74e-73	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HFNEBIIC_01090	1.4e-298	mepA	-	-	V	ko:K18908	-	ko00000,ko00002,ko01504,ko02000	MATE efflux family protein
HFNEBIIC_01091	2.79e-75	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
HFNEBIIC_01092	1.21e-122	-	-	-	P	-	-	-	Cadmium resistance transporter
HFNEBIIC_01093	5.63e-177	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01094	1.18e-196	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HFNEBIIC_01095	3.16e-233	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
HFNEBIIC_01096	8.98e-165	-	-	-	M	-	-	-	PFAM NLP P60 protein
HFNEBIIC_01097	5.85e-133	-	-	-	S	-	-	-	Protein of unknown function (DUF3278)
HFNEBIIC_01098	5.78e-39	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
HFNEBIIC_01099	5.09e-65	-	-	-	L	-	-	-	Integrase
HFNEBIIC_01100	2.7e-18	XK27_09155	-	-	K	-	-	-	Transcriptional
HFNEBIIC_01101	3.39e-131	cadD	-	-	P	-	-	-	Cadmium resistance transporter
HFNEBIIC_01102	3.57e-74	cadX	-	-	K	ko:K21903	-	ko00000,ko03000	Bacterial regulatory protein, arsR family
HFNEBIIC_01103	5.36e-93	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFNEBIIC_01104	8.43e-231	arsB	-	-	P	ko:K03325	-	ko00000,ko02000	Sodium Bile acid symporter family
HFNEBIIC_01105	2.1e-57	arsR	-	-	K	ko:K03892	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
HFNEBIIC_01106	1.21e-22	-	-	-	K	-	-	-	Helix-turn-helix domain
HFNEBIIC_01108	5.18e-26	-	-	-	L	-	-	-	Integrase core domain
HFNEBIIC_01109	2.55e-103	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	Transporter, major facilitator family protein
HFNEBIIC_01110	5.33e-44	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	ThiS family
HFNEBIIC_01111	3.65e-81	moaE	2.8.1.12	-	H	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	MoaE protein
HFNEBIIC_01112	7.28e-101	-	-	-	S	-	-	-	Flavodoxin
HFNEBIIC_01113	1.3e-165	fecD	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFNEBIIC_01114	4.07e-172	fecE	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HFNEBIIC_01115	1.04e-226	fecB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
HFNEBIIC_01116	2.76e-221	-	-	-	-	-	-	-	-
HFNEBIIC_01117	1.56e-95	-	-	-	-	-	-	-	-
HFNEBIIC_01118	1.47e-175	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HFNEBIIC_01119	2.49e-189	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HFNEBIIC_01120	7.16e-147	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HFNEBIIC_01121	9.31e-291	-	-	-	P	-	-	-	Chloride transporter, ClC family
HFNEBIIC_01122	1.24e-147	-	-	-	L	-	-	-	PFAM transposase IS116 IS110 IS902
HFNEBIIC_01123	0.0	agl	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
HFNEBIIC_01124	6.88e-144	-	-	-	I	-	-	-	Acid phosphatase homologues
HFNEBIIC_01125	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_01126	6.61e-195	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HFNEBIIC_01127	4.67e-164	ybbR	-	-	S	-	-	-	YbbR-like protein
HFNEBIIC_01128	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFNEBIIC_01129	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HFNEBIIC_01130	3e-69	-	-	-	-	-	-	-	-
HFNEBIIC_01131	0.0	oatA	-	-	I	-	-	-	Acyltransferase
HFNEBIIC_01132	6.2e-103	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01133	2.22e-190	-	-	-	S	-	-	-	Cof-like hydrolase
HFNEBIIC_01134	6.22e-107	lytE	-	-	M	-	-	-	Lysin motif
HFNEBIIC_01136	2.81e-174	yclJ	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
HFNEBIIC_01137	0.0	yclK	-	-	T	-	-	-	Histidine kinase
HFNEBIIC_01138	2.14e-197	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
HFNEBIIC_01139	1.84e-139	maa3	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
HFNEBIIC_01140	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
HFNEBIIC_01141	1.1e-35	-	-	-	-	-	-	-	-
HFNEBIIC_01144	1.19e-41	xylB	2.7.1.17, 2.7.1.53	-	G	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the FGGY kinase family
HFNEBIIC_01145	1.77e-197	-	-	-	KT	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	YcbB domain
HFNEBIIC_01146	9.21e-244	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HFNEBIIC_01147	3.94e-221	arcC	2.7.2.2	-	E	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	ko00000,ko00001,ko01000	Belongs to the carbamate kinase family
HFNEBIIC_01148	1.62e-203	-	-	-	EG	-	-	-	EamA-like transporter family
HFNEBIIC_01149	7.03e-134	XK27_08875	-	-	O	-	-	-	PFAM peptidase M10A and M12B, matrixin and adamalysin
HFNEBIIC_01150	4.39e-71	-	-	-	S	-	-	-	Cupredoxin-like domain
HFNEBIIC_01151	1.75e-62	-	-	-	S	-	-	-	Cupredoxin-like domain
HFNEBIIC_01152	0.0	copA	3.6.3.3, 3.6.3.5, 3.6.3.54	-	P	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
HFNEBIIC_01153	7.13e-110	-	-	-	-	-	-	-	-
HFNEBIIC_01155	1.5e-74	-	-	-	-	-	-	-	-
HFNEBIIC_01156	3.72e-48	nhaP3	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HFNEBIIC_01157	1.01e-147	nhaP3	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HFNEBIIC_01158	2.16e-58	nhaP3	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HFNEBIIC_01162	8.23e-88	-	-	-	-	-	-	-	-
HFNEBIIC_01169	5.44e-07	-	-	-	S	-	-	-	Helix-turn-helix domain
HFNEBIIC_01170	7.21e-50	-	-	-	K	-	-	-	BRO family, N-terminal domain
HFNEBIIC_01171	2.19e-39	-	-	-	-	-	-	-	-
HFNEBIIC_01173	1.11e-25	-	-	-	S	-	-	-	Helix-turn-helix domain
HFNEBIIC_01174	0.000267	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HFNEBIIC_01175	6.14e-170	int2	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_01177	4.12e-128	-	-	-	-	-	-	-	-
HFNEBIIC_01178	0.0	-	-	-	M	-	-	-	domain protein
HFNEBIIC_01179	5.16e-225	-	-	-	M	-	-	-	domain protein
HFNEBIIC_01180	1.82e-69	-	-	-	-	-	-	-	-
HFNEBIIC_01181	1.24e-232	ampC	-	-	V	-	-	-	Beta-lactamase
HFNEBIIC_01182	5.61e-292	arcA	3.5.3.6	-	E	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	ko00000,ko00001,ko01000	Arginine
HFNEBIIC_01183	6.17e-104	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HFNEBIIC_01184	0.0	arcD	-	-	E	ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
HFNEBIIC_01185	3.26e-296	potE	-	-	U	ko:K03756,ko:K03758	-	ko00000,ko02000	Amino acid permease
HFNEBIIC_01187	2.82e-172	-	-	-	S	ko:K07009	-	ko00000	CobB/CobQ-like glutamine amidotransferase domain
HFNEBIIC_01188	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Mur ligase, middle domain
HFNEBIIC_01189	6.8e-140	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
HFNEBIIC_01190	1.73e-248	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFNEBIIC_01191	4.07e-212	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HFNEBIIC_01192	1.09e-250	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HFNEBIIC_01193	2.03e-290	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFNEBIIC_01194	6.68e-150	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFNEBIIC_01195	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFNEBIIC_01196	9.53e-246	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
HFNEBIIC_01197	2.24e-164	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
HFNEBIIC_01198	2.3e-293	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
HFNEBIIC_01199	4.63e-162	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
HFNEBIIC_01200	1.26e-29	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFNEBIIC_01201	1.07e-95	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFNEBIIC_01202	6.84e-121	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFNEBIIC_01203	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFNEBIIC_01204	7.51e-212	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFNEBIIC_01205	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFNEBIIC_01206	7.36e-89	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
HFNEBIIC_01207	1.76e-45	ywzB	-	-	S	-	-	-	Protein of unknown function (DUF1146)
HFNEBIIC_01208	4.97e-307	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFNEBIIC_01209	2.57e-227	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
HFNEBIIC_01210	4.61e-44	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
HFNEBIIC_01211	9.49e-282	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
HFNEBIIC_01212	8.55e-64	gcsH2	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	glycine cleavage
HFNEBIIC_01213	7.38e-274	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
HFNEBIIC_01214	1.82e-191	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HFNEBIIC_01215	0.0	araP	-	-	U	-	-	-	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HFNEBIIC_01216	0.0	araB	2.7.1.16	-	G	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	carbohydrate kinase FGGY
HFNEBIIC_01217	1.34e-178	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HFNEBIIC_01218	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
HFNEBIIC_01219	2.21e-65	maa	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
HFNEBIIC_01220	2.65e-38	maa	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
HFNEBIIC_01221	5.7e-199	yvgN	-	-	S	-	-	-	Aldo keto reductase
HFNEBIIC_01222	5.7e-260	araR	-	-	K	ko:K02103	-	ko00000,ko03000	Transcriptional regulator
HFNEBIIC_01223	1.95e-109	uspA	-	-	T	-	-	-	universal stress protein
HFNEBIIC_01224	5.13e-61	-	-	-	-	-	-	-	-
HFNEBIIC_01225	1.8e-307	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HFNEBIIC_01226	8.27e-111	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HFNEBIIC_01227	2.31e-28	-	-	-	-	-	-	-	-
HFNEBIIC_01228	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_01230	6.21e-57	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HFNEBIIC_01231	3.04e-100	-	-	-	S	-	-	-	Transcriptional regulator, RinA family
HFNEBIIC_01232	0.0	-	-	-	S	ko:K06904	-	ko00000	Caudovirus prohead serine protease
HFNEBIIC_01233	2.07e-261	-	-	-	S	-	-	-	Phage portal protein
HFNEBIIC_01235	0.0	terL	-	-	S	-	-	-	overlaps another CDS with the same product name
HFNEBIIC_01236	3.55e-99	terS	-	-	L	-	-	-	Phage terminase, small subunit
HFNEBIIC_01237	1.24e-109	-	-	-	L	-	-	-	HNH nucleases
HFNEBIIC_01240	0.0	-	-	-	S	ko:K06919	-	ko00000	Phage plasmid primase, P4
HFNEBIIC_01244	1.25e-06	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HFNEBIIC_01245	0.000175	-	-	-	P	-	-	-	Helix-turn-helix domain
HFNEBIIC_01247	2.23e-54	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_01248	8.86e-122	-	-	-	-	-	-	-	-
HFNEBIIC_01249	1.25e-119	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFNEBIIC_01250	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HFNEBIIC_01251	9.7e-198	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
HFNEBIIC_01252	2.79e-225	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HFNEBIIC_01253	4.75e-316	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFNEBIIC_01254	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HFNEBIIC_01255	4.93e-20	-	-	-	-	-	-	-	-
HFNEBIIC_01256	1.11e-78	-	-	-	S	-	-	-	mazG nucleotide pyrophosphohydrolase
HFNEBIIC_01257	2.86e-139	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
HFNEBIIC_01258	2.06e-297	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HFNEBIIC_01259	5.54e-303	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HFNEBIIC_01260	4.94e-288	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFNEBIIC_01261	3.58e-208	-	-	-	S	-	-	-	Tetratricopeptide repeat
HFNEBIIC_01262	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFNEBIIC_01263	1.74e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFNEBIIC_01264	1.44e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
HFNEBIIC_01265	2.27e-200	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
HFNEBIIC_01266	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
HFNEBIIC_01267	2.47e-116	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
HFNEBIIC_01268	4.83e-138	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
HFNEBIIC_01269	2.03e-250	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
HFNEBIIC_01270	3.56e-115	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFNEBIIC_01271	9.98e-126	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
HFNEBIIC_01272	6.37e-60	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
HFNEBIIC_01273	1.77e-282	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HFNEBIIC_01274	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
HFNEBIIC_01275	4.59e-173	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
HFNEBIIC_01276	1.32e-59	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
HFNEBIIC_01277	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
HFNEBIIC_01278	5.01e-310	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HFNEBIIC_01279	1.34e-231	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, C-terminal domain protein
HFNEBIIC_01280	6.71e-265	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
HFNEBIIC_01281	2.78e-132	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HFNEBIIC_01282	3.66e-103	-	-	-	-	-	-	-	-
HFNEBIIC_01283	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_01284	1.76e-258	xerS	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_01286	1.39e-91	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HFNEBIIC_01287	1.94e-100	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
HFNEBIIC_01288	1.46e-214	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFNEBIIC_01289	1.99e-44	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFNEBIIC_01290	2e-196	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
HFNEBIIC_01291	9.64e-164	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
HFNEBIIC_01292	8.74e-280	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HFNEBIIC_01293	7.24e-97	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HFNEBIIC_01294	1.27e-94	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HFNEBIIC_01295	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
HFNEBIIC_01296	1.62e-181	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HFNEBIIC_01297	1.81e-175	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	alpha subunit
HFNEBIIC_01298	3.21e-167	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
HFNEBIIC_01307	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HFNEBIIC_01308	3.99e-34	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HFNEBIIC_01309	1.29e-261	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
HFNEBIIC_01310	2.64e-315	-	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	pyridine nucleotide-disulfide oxidoreductase
HFNEBIIC_01311	2.38e-109	yvbK	-	-	K	-	-	-	GNAT family
HFNEBIIC_01312	6.93e-118	-	-	-	-	-	-	-	-
HFNEBIIC_01313	1.52e-158	pnb	-	-	C	-	-	-	nitroreductase
HFNEBIIC_01314	5.29e-109	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Methyltransferase
HFNEBIIC_01315	1.33e-119	-	3.2.1.96, 3.5.1.28	GH73	M	ko:K01227,ko:K01447,ko:K13714,ko:K13731	ko00511,ko05100,map00511,map05100	ko00000,ko00001,ko01000	N-acetylmuramoyl-L-alanine amidase
HFNEBIIC_01316	1.21e-94	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
HFNEBIIC_01317	1.18e-99	-	-	-	K	-	-	-	LytTr DNA-binding domain
HFNEBIIC_01318	1.4e-117	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
HFNEBIIC_01319	3.59e-150	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
HFNEBIIC_01320	4.36e-103	yjcF	3.5.4.33, 4.4.1.8	-	K	ko:K02348,ko:K07000,ko:K11991,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007,ko03016	protein acetylation
HFNEBIIC_01321	1.36e-248	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
HFNEBIIC_01322	0.0	gshA	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
HFNEBIIC_01323	2.16e-212	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HFNEBIIC_01324	6.2e-137	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
HFNEBIIC_01325	4.62e-81	-	-	-	S	-	-	-	Domain of unknown function (DUF4828)
HFNEBIIC_01326	6.24e-244	mocA	-	-	S	-	-	-	Oxidoreductase
HFNEBIIC_01327	1.83e-295	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
HFNEBIIC_01329	3.46e-265	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HFNEBIIC_01330	1e-72	-	-	-	-	-	-	-	-
HFNEBIIC_01331	2.45e-88	gtcA	-	-	S	-	-	-	Teichoic acid glycosylation protein
HFNEBIIC_01332	1.92e-102	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HFNEBIIC_01333	4.96e-216	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
HFNEBIIC_01334	3.82e-278	arcT	-	-	E	-	-	-	Aminotransferase
HFNEBIIC_01335	0.0	arcD	-	-	E	ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
HFNEBIIC_01336	0.0	potE	-	-	E	-	-	-	Amino Acid
HFNEBIIC_01337	4.14e-200	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
HFNEBIIC_01338	1.26e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2922)
HFNEBIIC_01339	4.22e-41	-	-	-	-	-	-	-	-
HFNEBIIC_01340	2.25e-172	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
HFNEBIIC_01341	7.48e-185	cps1D	-	-	M	-	-	-	Domain of unknown function (DUF4422)
HFNEBIIC_01342	7.35e-221	yfdH	-	GT2	M	ko:K12999	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HFNEBIIC_01343	2.32e-152	-	-	-	M	-	-	-	Bacterial sugar transferase
HFNEBIIC_01344	7.88e-129	cps3F	-	-	-	-	-	-	-
HFNEBIIC_01346	1.38e-275	glf	5.4.99.9	-	M	ko:K01854	ko00052,ko00520,map00052,map00520	ko00000,ko00001,ko01000	UDP-galactopyranose mutase
HFNEBIIC_01347	6.6e-222	cps1C	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
HFNEBIIC_01348	3.41e-89	-	-	-	S	-	-	-	enterobacterial common antigen metabolic process
HFNEBIIC_01349	4.05e-119	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
HFNEBIIC_01350	2.9e-143	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
HFNEBIIC_01351	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
HFNEBIIC_01353	1.98e-278	-	-	-	S	ko:K07133	-	ko00000	cog cog1373
HFNEBIIC_01354	8.32e-226	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HFNEBIIC_01355	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HFNEBIIC_01356	1.45e-201	-	-	-	EG	-	-	-	EamA-like transporter family
HFNEBIIC_01357	1.59e-48	-	-	-	Q	-	-	-	pyridine nucleotide-disulphide oxidoreductase
HFNEBIIC_01358	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HFNEBIIC_01359	1.9e-147	-	-	-	S	ko:K03975	-	ko00000	SNARE associated Golgi protein
HFNEBIIC_01360	6.69e-162	pgm3	-	-	G	-	-	-	phosphoglycerate mutase
HFNEBIIC_01361	1.09e-292	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFNEBIIC_01362	5.25e-45	-	-	-	S	-	-	-	Transglycosylase associated protein
HFNEBIIC_01363	1.31e-09	-	-	-	S	-	-	-	CsbD-like
HFNEBIIC_01364	1.89e-229	-	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFNEBIIC_01365	0.0	yhgE	-	-	V	ko:K01421	-	ko00000	domain protein
HFNEBIIC_01366	2.14e-123	-	-	-	K	-	-	-	Transcriptional regulator (TetR family)
HFNEBIIC_01367	1.23e-52	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain protein
HFNEBIIC_01368	2.21e-191	-	-	-	-	-	-	-	-
HFNEBIIC_01369	2.52e-30	-	3.2.1.14	GH18	-	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	-
HFNEBIIC_01370	1.48e-107	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
HFNEBIIC_01371	3.1e-131	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase
HFNEBIIC_01372	3.46e-95	-	-	-	F	-	-	-	Nudix hydrolase
HFNEBIIC_01373	0.0	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
HFNEBIIC_01374	1.89e-293	-	-	-	EGP	ko:K08368	-	ko00000,ko02000	Sugar (and other) transporter
HFNEBIIC_01376	0.0	sufI	-	-	Q	-	-	-	Multicopper oxidase
HFNEBIIC_01377	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFNEBIIC_01378	1.63e-81	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HFNEBIIC_01379	2.96e-141	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
HFNEBIIC_01380	2.98e-218	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HFNEBIIC_01382	1.62e-48	ldh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	lactate/malate dehydrogenase, NAD binding domain
HFNEBIIC_01383	1.74e-107	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
HFNEBIIC_01384	1.09e-134	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
HFNEBIIC_01385	5.44e-51	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HFNEBIIC_01386	3.88e-260	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
HFNEBIIC_01387	4.64e-130	-	-	-	S	ko:K07160	-	ko00000	LamB/YcsF family
HFNEBIIC_01388	1.22e-228	ycsG	-	-	P	-	-	-	Natural resistance-associated macrophage protein
HFNEBIIC_01389	5.78e-96	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HFNEBIIC_01390	3.52e-59	ydeP	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HFNEBIIC_01391	3.85e-206	qor	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
HFNEBIIC_01394	1.56e-212	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
HFNEBIIC_01395	0.0	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HFNEBIIC_01396	4.98e-48	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HFNEBIIC_01397	1.29e-299	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
HFNEBIIC_01398	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HFNEBIIC_01399	4.54e-09	dltX	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
HFNEBIIC_01400	8.96e-79	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HFNEBIIC_01401	1.41e-265	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFNEBIIC_01402	5.31e-82	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
HFNEBIIC_01403	0.0	-	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
HFNEBIIC_01404	1.59e-308	codA	3.5.4.1	-	F	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000	cytosine deaminase
HFNEBIIC_01405	3.27e-185	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
HFNEBIIC_01406	9.43e-146	-	-	-	S	-	-	-	(CBS) domain
HFNEBIIC_01407	9.32e-131	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HFNEBIIC_01408	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFNEBIIC_01409	3.11e-51	yabO	-	-	J	-	-	-	S4 domain protein
HFNEBIIC_01410	1.02e-74	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
HFNEBIIC_01411	5.75e-103	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding
HFNEBIIC_01412	0.0	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HFNEBIIC_01413	8.67e-124	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HFNEBIIC_01414	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFNEBIIC_01415	9.26e-218	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFNEBIIC_01416	6.21e-241	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFNEBIIC_01417	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
HFNEBIIC_01418	6.04e-109	-	-	-	-	-	-	-	-
HFNEBIIC_01419	4.68e-197	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HFNEBIIC_01420	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HFNEBIIC_01421	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HFNEBIIC_01422	2.14e-203	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
HFNEBIIC_01423	4.93e-123	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
HFNEBIIC_01424	5.7e-114	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFNEBIIC_01425	2.5e-153	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
HFNEBIIC_01426	5.32e-208	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
HFNEBIIC_01427	8.28e-177	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HFNEBIIC_01428	9.19e-193	-	-	-	G	-	-	-	Right handed beta helix region
HFNEBIIC_01429	0.0	pps	2.7.9.2	-	H	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HFNEBIIC_01430	1.18e-159	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	sortase family
HFNEBIIC_01431	1.78e-210	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HFNEBIIC_01432	1.46e-299	pts13C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HFNEBIIC_01433	9.43e-56	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
HFNEBIIC_01434	1.11e-301	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFNEBIIC_01435	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HFNEBIIC_01436	2.68e-80	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HFNEBIIC_01437	3.15e-71	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
HFNEBIIC_01438	4.49e-193	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	biotin lipoate A B protein ligase
HFNEBIIC_01439	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	HD domain protein
HFNEBIIC_01440	7.71e-189	yidA	-	-	S	-	-	-	hydrolase
HFNEBIIC_01441	1.19e-98	-	-	-	-	-	-	-	-
HFNEBIIC_01442	3.53e-229	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFNEBIIC_01443	2.14e-312	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFNEBIIC_01444	2.09e-190	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
HFNEBIIC_01445	1.75e-165	-	-	-	U	ko:K02075	-	ko00000,ko00002,ko02000	ABC 3 transport family
HFNEBIIC_01446	1.98e-157	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HFNEBIIC_01447	1.93e-213	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HFNEBIIC_01448	1.71e-206	ispE	2.7.1.148	-	F	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HFNEBIIC_01449	2.74e-50	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
HFNEBIIC_01450	1.03e-205	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HFNEBIIC_01451	4.08e-126	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HFNEBIIC_01452	3.58e-198	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
HFNEBIIC_01453	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFNEBIIC_01454	3.2e-206	yunF	-	-	F	-	-	-	Protein of unknown function DUF72
HFNEBIIC_01456	4.85e-167	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	SIR2 family
HFNEBIIC_01457	3.01e-225	-	-	-	-	-	-	-	-
HFNEBIIC_01458	8.26e-290	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
HFNEBIIC_01459	4.38e-215	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HFNEBIIC_01460	2.26e-242	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HFNEBIIC_01461	8.74e-234	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Belongs to the N(4) N(6)-methyltransferase family
HFNEBIIC_01462	4.08e-106	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Belongs to the NDK family
HFNEBIIC_01463	0.0	-	-	-	L	-	-	-	DNA helicase
HFNEBIIC_01464	1.1e-260	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HFNEBIIC_01466	0.0	gabT	2.6.1.19, 5.1.1.21	-	E	ko:K00823,ko:K20708	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFNEBIIC_01467	0.0	ctrA	-	-	E	ko:K03294	-	ko00000	amino acid
HFNEBIIC_01468	1.64e-151	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFNEBIIC_01469	5.74e-54	-	1.3.5.4	-	S	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FMN binding
HFNEBIIC_01470	5.93e-281	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	transporter
HFNEBIIC_01471	1.21e-215	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HFNEBIIC_01472	3.42e-197	metQ	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HFNEBIIC_01473	2.85e-243	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFNEBIIC_01474	5.25e-140	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_01475	2.2e-272	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HFNEBIIC_01476	2.51e-147	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HFNEBIIC_01477	7.7e-104	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
HFNEBIIC_01478	1.32e-136	-	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, permease protein
HFNEBIIC_01479	3.69e-183	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01480	6.73e-139	proWZ	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HFNEBIIC_01481	3.07e-208	proWY	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, QAT family
HFNEBIIC_01482	3.71e-95	ywnA	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01483	7.59e-66	-	-	-	GM	-	-	-	NAD(P)H-binding
HFNEBIIC_01484	1.89e-45	-	-	-	GM	-	-	-	NAD(P)H-binding
HFNEBIIC_01485	4.44e-11	-	-	-	-	-	-	-	-
HFNEBIIC_01486	1.4e-280	-	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Metalloenzyme superfamily
HFNEBIIC_01487	0.0	cadA	-	-	P	-	-	-	P-type ATPase
HFNEBIIC_01488	2.65e-161	XK27_08875	-	-	O	-	-	-	PFAM peptidase M10A and M12B, matrixin and adamalysin
HFNEBIIC_01489	8.65e-162	-	-	-	-	-	-	-	-
HFNEBIIC_01490	1.85e-69	-	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
HFNEBIIC_01491	4.48e-312	-	1.8.1.7	-	C	ko:K00383,ko:K21739	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Pyridine nucleotide-disulfide oxidoreductase
HFNEBIIC_01493	0.0	-	-	-	L	-	-	-	Helicase C-terminal domain protein
HFNEBIIC_01494	1.2e-105	-	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	PAP2 superfamily
HFNEBIIC_01495	2.21e-226	ydhF	-	-	S	-	-	-	Aldo keto reductase
HFNEBIIC_01497	5.03e-181	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HFNEBIIC_01498	2.1e-35	psiE	-	-	S	ko:K13256	-	ko00000	Phosphate-starvation-inducible E
HFNEBIIC_01499	2.31e-128	-	-	-	S	ko:K07002	-	ko00000	Serine hydrolase
HFNEBIIC_01501	5.64e-232	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFNEBIIC_01502	0.0	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
HFNEBIIC_01503	1.28e-49	-	-	-	S	-	-	-	Cytochrome b5-like Heme/Steroid binding domain
HFNEBIIC_01504	9.4e-148	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
HFNEBIIC_01505	4.54e-49	-	-	-	-	-	-	-	-
HFNEBIIC_01506	5.57e-164	-	-	-	IQ	-	-	-	dehydrogenase reductase
HFNEBIIC_01507	3.92e-305	-	-	-	EGP	-	-	-	MFS transporter, metabolite H symporter (MHS) family protein
HFNEBIIC_01508	1.17e-30	-	-	-	M	-	-	-	Rib/alpha-like repeat
HFNEBIIC_01509	1.18e-200	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HFNEBIIC_01510	3.45e-206	-	-	-	S	-	-	-	EDD domain protein, DegV family
HFNEBIIC_01511	4.82e-120	-	-	-	-	-	-	-	-
HFNEBIIC_01512	9.78e-151	yagB	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HFNEBIIC_01513	3.44e-201	gspA	-	-	M	-	-	-	family 8
HFNEBIIC_01514	3.56e-198	-	-	-	S	-	-	-	Alpha beta hydrolase
HFNEBIIC_01515	4.41e-119	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HFNEBIIC_01517	2.23e-14	sip	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_01518	1.09e-114	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
HFNEBIIC_01519	6.68e-71	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
HFNEBIIC_01520	3.26e-163	-	-	-	L	-	-	-	Helix-turn-helix domain
HFNEBIIC_01521	4.44e-17	-	-	-	K	-	-	-	Helix-turn-helix domain
HFNEBIIC_01522	3.88e-105	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HFNEBIIC_01524	2.21e-87	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_01525	0.0	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HFNEBIIC_01526	5.6e-93	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	ECF transporter, substrate-specific component
HFNEBIIC_01527	1.04e-204	cobT	2.4.2.21	-	F	ko:K00768	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
HFNEBIIC_01528	1.67e-128	-	-	-	H	-	-	-	Uroporphyrinogen-III synthase
HFNEBIIC_01529	3.26e-104	cobC	3.1.3.73	-	G	ko:K02226	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the phosphoglycerate mutase family
HFNEBIIC_01530	1.27e-152	cobS	2.7.8.26	-	H	ko:K02233	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HFNEBIIC_01531	1.48e-110	cobU	2.7.1.156, 2.7.7.62	-	H	ko:K02231	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobinamide kinase / cobinamide phosphate guanyltransferase
HFNEBIIC_01532	3.13e-311	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
HFNEBIIC_01533	4.79e-224	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Delta-aminolevulinic acid dehydratase
HFNEBIIC_01534	6.08e-186	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HFNEBIIC_01535	2.77e-261	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HFNEBIIC_01536	2.29e-85	cysG	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Putative NAD(P)-binding
HFNEBIIC_01537	0.0	cobQ	6.3.5.10	-	H	ko:K02232	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
HFNEBIIC_01538	7.04e-176	cbiO	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	part of an ABC transporter complex. Responsible for energy coupling to the transport system
HFNEBIIC_01539	2.15e-137	cbiQ	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
HFNEBIIC_01540	7.97e-65	cbiN	-	-	P	ko:K02009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HFNEBIIC_01541	9.62e-166	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HFNEBIIC_01542	2.07e-134	cbiL	2.1.1.130, 2.1.1.151	-	H	ko:K03394	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
HFNEBIIC_01543	9.91e-153	cbiK	4.99.1.3	-	H	ko:K02190	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Cobalt chelatase (CbiK)
HFNEBIIC_01544	1.67e-249	cobA	2.1.1.107, 4.2.1.75	-	H	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
HFNEBIIC_01545	4.87e-145	cobK	1.3.1.106, 1.3.1.54	-	H	ko:K05895	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Precorrin-6x reductase CbiJ/CobK
HFNEBIIC_01546	9.71e-167	cbiH	2.1.1.131	-	H	ko:K05934	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
HFNEBIIC_01547	6.56e-197	cbiG	3.7.1.12	-	H	ko:K02189	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Cobalamin synthesis G C-terminus
HFNEBIIC_01548	1.08e-169	cbiF	2.1.1.133, 2.1.1.271	-	H	ko:K05936	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
HFNEBIIC_01549	2.06e-108	cbiT	2.1.1.196	-	H	ko:K02191	ko00860,map00860	ko00000,ko00001,ko01000	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
HFNEBIIC_01550	4.23e-118	cbiE	2.1.1.289	-	H	ko:K03399	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
HFNEBIIC_01551	4.24e-251	cbiD	2.1.1.195	-	H	ko:K02188	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HFNEBIIC_01552	1.06e-138	cbiC	5.4.99.60, 5.4.99.61	-	H	ko:K06042	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Precorrin-8X methylmutase
HFNEBIIC_01553	5.36e-203	cobD	6.3.1.10	-	H	ko:K02227	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HFNEBIIC_01554	8.57e-280	cbiA	6.3.5.11, 6.3.5.9	-	F	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
HFNEBIIC_01555	2.66e-220	cobD	4.1.1.81	-	E	ko:K04720	ko00860,map00860	ko00000,ko00001,ko01000	Aminotransferase class I and II
HFNEBIIC_01556	1.15e-116	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobalamin adenosyltransferase
HFNEBIIC_01557	1.16e-91	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HFNEBIIC_01558	3.92e-100	-	-	-	P	-	-	-	Cadmium resistance transporter
HFNEBIIC_01559	1.78e-129	pgm1	-	-	G	-	-	-	phosphoglycerate mutase
HFNEBIIC_01560	1.04e-190	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HFNEBIIC_01561	2.22e-169	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HFNEBIIC_01562	3.47e-161	-	-	-	-	-	-	-	-
HFNEBIIC_01563	4.67e-198	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
HFNEBIIC_01564	4.09e-235	XK27_12525	-	-	S	-	-	-	AI-2E family transporter
HFNEBIIC_01565	3.53e-169	XK27_07210	-	-	S	-	-	-	B3 4 domain
HFNEBIIC_01566	8.16e-103	yybA	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01567	5.04e-116	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
HFNEBIIC_01568	9.43e-116	-	-	-	GM	-	-	-	epimerase
HFNEBIIC_01569	8.05e-198	-	-	-	V	-	-	-	(ABC) transporter
HFNEBIIC_01570	3.6e-302	yhdP	-	-	S	-	-	-	Transporter associated domain
HFNEBIIC_01571	3.16e-107	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
HFNEBIIC_01572	4.3e-96	-	-	-	S	ko:K04750	-	ko00000	3-demethylubiquinone-9 3-methyltransferase
HFNEBIIC_01573	1.86e-240	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	Transporter, major facilitator family protein
HFNEBIIC_01574	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFNEBIIC_01575	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFNEBIIC_01576	4.67e-39	-	-	-	-	-	-	-	-
HFNEBIIC_01577	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
HFNEBIIC_01578	2.21e-87	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HFNEBIIC_01580	1.32e-227	ldhA	1.1.1.28	-	C	ko:K03778,ko:K18347	ko00620,ko01120,ko01502,ko02020,map00620,map01120,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01504	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFNEBIIC_01581	7.21e-126	-	-	-	IQ	-	-	-	KR domain
HFNEBIIC_01582	4.44e-122	eutJ	-	-	E	ko:K04024	-	ko00000	Hsp70 protein
HFNEBIIC_01583	2.34e-18	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01584	4.05e-44	-	-	-	CQ	-	-	-	BMC
HFNEBIIC_01585	3.09e-111	pduB	-	-	E	-	-	-	BMC
HFNEBIIC_01586	0.0	pduC	4.2.1.28	-	Q	ko:K01699	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase large subunit
HFNEBIIC_01587	2.6e-101	pduD	4.2.1.28	-	Q	ko:K13919	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase medium subunit
HFNEBIIC_01588	1.44e-61	pduE	4.2.1.28	-	Q	ko:K13920	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase small subunit
HFNEBIIC_01589	0.0	pduG	-	-	D	-	-	-	Diol dehydratase reactivase ATPase-like domain
HFNEBIIC_01590	4.64e-41	pduH	-	-	S	-	-	-	Dehydratase medium subunit
HFNEBIIC_01591	2.45e-43	-	-	-	CQ	-	-	-	BMC
HFNEBIIC_01592	2.78e-46	pduJ	-	-	CQ	-	-	-	BMC
HFNEBIIC_01593	7.69e-61	-	-	-	S	-	-	-	Putative propanediol utilisation
HFNEBIIC_01594	8.64e-43	pduN	-	-	CQ	ko:K04028	-	ko00000	Ethanolamine utilisation protein EutN/carboxysome
HFNEBIIC_01595	1.6e-101	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
HFNEBIIC_01596	1.9e-63	pduO	-	-	S	-	-	-	Haem-degrading
HFNEBIIC_01598	7.26e-64	-	-	-	E	ko:K04031	-	ko00000	BMC
HFNEBIIC_01599	2.34e-73	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Pfam:Y_phosphatase3C
HFNEBIIC_01600	1.27e-48	-	-	-	P	-	-	-	Cadmium resistance transporter
HFNEBIIC_01601	4.75e-64	eutP	-	-	E	ko:K04029	-	ko00000	Ethanolamine utilisation - propanediol utilisation
HFNEBIIC_01602	1.48e-84	nqo1	-	-	S	ko:K19784	-	ko00000	NADPH-dependent FMN reductase
HFNEBIIC_01603	0.0	ycfI	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01604	0.0	yfiC	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HFNEBIIC_01605	0.0	rtpR	1.17.4.2	-	F	ko:K00527	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	ribonucleoside-triphosphate reductase activity
HFNEBIIC_01606	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HFNEBIIC_01607	1.85e-110	ebsC	-	-	J	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFNEBIIC_01608	8.56e-162	gntR	-	-	K	-	-	-	UbiC transcription regulator-associated domain protein
HFNEBIIC_01609	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HFNEBIIC_01610	3.03e-183	-	-	-	E	-	-	-	amino acid
HFNEBIIC_01611	1.83e-99	-	-	-	E	-	-	-	amino acid
HFNEBIIC_01612	6.07e-175	yfhR3	-	-	S	ko:K06889	-	ko00000	Serine hydrolase (FSH1)
HFNEBIIC_01613	9.34e-309	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HFNEBIIC_01614	2.96e-211	-	-	-	GK	-	-	-	ROK family
HFNEBIIC_01615	0.0	fusA1	-	-	J	-	-	-	elongation factor G
HFNEBIIC_01616	7.46e-106	uspA3	-	-	T	-	-	-	universal stress protein
HFNEBIIC_01617	1e-248	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
HFNEBIIC_01618	1.78e-83	-	-	-	-	-	-	-	-
HFNEBIIC_01619	2.31e-11	-	-	-	-	-	-	-	-
HFNEBIIC_01620	1.45e-145	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HFNEBIIC_01621	4.56e-175	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HFNEBIIC_01622	4.58e-269	-	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_01623	0.0	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system Galactitol-specific IIC component
HFNEBIIC_01624	1.37e-213	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
HFNEBIIC_01625	1.4e-109	-	-	-	K	-	-	-	FCD
HFNEBIIC_01626	6.43e-214	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
HFNEBIIC_01627	9.72e-167	idhA	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFNEBIIC_01628	1.92e-204	-	-	-	-	-	-	-	-
HFNEBIIC_01629	2.16e-94	-	-	-	K	-	-	-	Transcriptional regulator
HFNEBIIC_01630	4.14e-231	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HFNEBIIC_01631	1.82e-68	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
HFNEBIIC_01632	0.0	nhaK	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HFNEBIIC_01633	6.5e-71	-	-	-	-	-	-	-	-
HFNEBIIC_01634	4.63e-144	-	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
HFNEBIIC_01635	1.81e-316	-	-	-	S	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01636	3e-127	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
HFNEBIIC_01637	1.47e-171	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HFNEBIIC_01638	9e-144	-	-	-	IQ	-	-	-	KR domain
HFNEBIIC_01639	5.68e-12	-	-	-	IQ	-	-	-	KR domain
HFNEBIIC_01640	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HFNEBIIC_01641	6.09e-226	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HFNEBIIC_01642	0.0	atp2C1	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HFNEBIIC_01643	4.16e-112	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
HFNEBIIC_01644	5.72e-64	yagE	-	-	E	-	-	-	amino acid
HFNEBIIC_01645	4.69e-224	yagE	-	-	E	-	-	-	amino acid
HFNEBIIC_01646	2.14e-148	-	-	-	S	-	-	-	HAD hydrolase, family IA, variant
HFNEBIIC_01647	5.17e-24	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HFNEBIIC_01648	6.92e-70	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HFNEBIIC_01649	1.91e-43	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HFNEBIIC_01650	9.79e-233	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
HFNEBIIC_01651	5.46e-233	iunH1	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
HFNEBIIC_01652	5.14e-70	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HFNEBIIC_01653	1.06e-55	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HFNEBIIC_01654	2.71e-103	usp5	-	-	T	-	-	-	universal stress protein
HFNEBIIC_01655	3.83e-104	-	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	AsnC family
HFNEBIIC_01656	1.61e-291	gltT	-	-	U	ko:K03309,ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HFNEBIIC_01657	1.88e-135	apl	3.1.3.1	-	S	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	SNARE associated Golgi protein
HFNEBIIC_01658	1.69e-232	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HFNEBIIC_01659	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
HFNEBIIC_01660	1.03e-287	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HFNEBIIC_01661	9.63e-221	celE3	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
HFNEBIIC_01662	2.6e-185	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HFNEBIIC_01663	9.21e-120	-	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
HFNEBIIC_01664	1.21e-48	-	-	-	-	-	-	-	-
HFNEBIIC_01665	1.76e-68	-	-	-	-	-	-	-	-
HFNEBIIC_01666	5.88e-257	-	-	-	-	-	-	-	-
HFNEBIIC_01667	1.93e-106	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HFNEBIIC_01668	9.74e-176	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
HFNEBIIC_01669	8.44e-201	yvgN	-	-	S	-	-	-	Aldo keto reductase
HFNEBIIC_01670	3.05e-161	XK27_10500	-	-	K	-	-	-	response regulator
HFNEBIIC_01671	8.72e-233	kinG	-	-	T	-	-	-	Histidine kinase-like ATPases
HFNEBIIC_01672	9.68e-172	XK27_05695	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01673	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HFNEBIIC_01674	3.31e-200	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to
HFNEBIIC_01675	7.55e-213	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HFNEBIIC_01676	7.86e-13	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HFNEBIIC_01677	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFNEBIIC_01678	4.05e-250	-	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_01679	4.06e-111	ymdB	-	-	S	-	-	-	Macro domain protein
HFNEBIIC_01680	1.51e-137	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HFNEBIIC_01681	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HFNEBIIC_01682	8.55e-64	-	-	-	-	-	-	-	-
HFNEBIIC_01683	4.14e-295	-	-	-	S	-	-	-	Putative metallopeptidase domain
HFNEBIIC_01684	1.2e-260	-	-	-	S	-	-	-	associated with various cellular activities
HFNEBIIC_01685	8.15e-155	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
HFNEBIIC_01686	2.01e-84	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
HFNEBIIC_01688	1.43e-152	yrkL	-	-	S	-	-	-	Flavodoxin-like fold
HFNEBIIC_01689	9.17e-70	-	-	-	-	-	-	-	-
HFNEBIIC_01691	7.29e-37	-	2.1.1.72	-	D	ko:K03427	-	ko00000,ko01000,ko02048	peptidase
HFNEBIIC_01692	6.87e-64	-	-	-	-	-	-	-	-
HFNEBIIC_01693	4.53e-263	yngD	-	-	S	ko:K07097	-	ko00000	DHHA1 domain
HFNEBIIC_01694	8.26e-290	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
HFNEBIIC_01695	7.21e-316	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HFNEBIIC_01696	4.92e-136	-	-	-	NU	-	-	-	mannosyl-glycoprotein
HFNEBIIC_01697	3.82e-182	-	-	-	S	-	-	-	Putative ABC-transporter type IV
HFNEBIIC_01698	0.0	-	-	-	S	-	-	-	ABC transporter, ATP-binding protein
HFNEBIIC_01699	2.27e-24	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
HFNEBIIC_01700	4.15e-23	-	-	-	K	-	-	-	Helix-turn-helix domain
HFNEBIIC_01702	5.67e-53	-	-	-	S	-	-	-	Protein of unknown function (DUF1797)
HFNEBIIC_01703	1.61e-229	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFNEBIIC_01704	7.98e-253	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HFNEBIIC_01705	5.39e-292	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HFNEBIIC_01706	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFNEBIIC_01707	3.69e-54	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
HFNEBIIC_01708	1.38e-37	-	-	-	-	-	-	-	-
HFNEBIIC_01709	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
HFNEBIIC_01710	1.56e-130	-	-	-	S	-	-	-	Pfam:DUF3816
HFNEBIIC_01711	1.29e-180	-	-	-	G	-	-	-	MucBP domain
HFNEBIIC_01712	1.17e-147	-	-	-	-	-	-	-	-
HFNEBIIC_01713	1.06e-200	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01714	7.18e-86	-	-	-	K	-	-	-	Transcriptional regulator, GntR family
HFNEBIIC_01715	4.65e-59	-	-	-	V	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
HFNEBIIC_01716	1.53e-64	-	-	-	M	-	-	-	Peptidase_C39 like family
HFNEBIIC_01717	2.54e-60	p75	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
HFNEBIIC_01718	3.59e-283	ganB	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
HFNEBIIC_01719	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFNEBIIC_01720	3.55e-303	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HFNEBIIC_01721	1.52e-231	yueF	-	-	S	-	-	-	AI-2E family transporter
HFNEBIIC_01722	1.99e-81	-	-	-	S	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	dextransucrase activity
HFNEBIIC_01723	7.45e-31	-	-	-	M	-	-	-	CotH kinase protein
HFNEBIIC_01724	1.16e-102	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HFNEBIIC_01725	1.38e-123	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
HFNEBIIC_01726	6.02e-52	-	-	-	S	-	-	-	Acyltransferase family
HFNEBIIC_01727	7.84e-42	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NLP P60 protein
HFNEBIIC_01728	2.23e-176	-	-	-	M	-	-	-	Glycosyl transferase family 2
HFNEBIIC_01730	6.47e-36	-	-	-	-	-	-	-	-
HFNEBIIC_01731	1.57e-145	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NLP P60 protein
HFNEBIIC_01732	6.79e-51	-	-	-	M	-	-	-	KxYKxGKxW signal domain protein
HFNEBIIC_01733	4.03e-18	-	-	-	L	-	-	-	Putative ATPase subunit of terminase (gpP-like)
HFNEBIIC_01734	2.39e-68	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
HFNEBIIC_01735	3.92e-139	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NLP P60 protein
HFNEBIIC_01736	2.44e-57	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HFNEBIIC_01737	6.57e-81	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
HFNEBIIC_01738	1.79e-12	-	-	-	L	-	-	-	PFAM Integrase catalytic region
HFNEBIIC_01739	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
HFNEBIIC_01740	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HFNEBIIC_01741	4.03e-208	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko01000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFNEBIIC_01742	2.33e-233	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HFNEBIIC_01743	0.0	ade	-	-	F	-	-	-	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFNEBIIC_01744	1.84e-95	-	-	-	L	-	-	-	Helix-turn-helix domain
HFNEBIIC_01745	9.95e-169	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
HFNEBIIC_01746	2.95e-106	yeeA	-	-	V	-	-	-	Type II restriction enzyme, methylase subunits
HFNEBIIC_01748	4.63e-183	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_01749	1.32e-36	-	-	-	L	-	-	-	Transposase and inactivated derivatives IS30 family
HFNEBIIC_01750	3.76e-130	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HFNEBIIC_01751	7.83e-101	-	-	-	L	-	-	-	Integrase core domain
HFNEBIIC_01752	2.61e-133	-	-	-	L	-	-	-	Integrase core domain
HFNEBIIC_01753	2.13e-71	-	-	-	D	-	-	-	Domain of Unknown Function (DUF1542)
HFNEBIIC_01754	1.11e-237	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HFNEBIIC_01755	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
HFNEBIIC_01756	0.0	lacZ	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	-beta-galactosidase
HFNEBIIC_01757	1.03e-172	-	-	-	D	-	-	-	transport
HFNEBIIC_01758	2.3e-228	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HFNEBIIC_01759	8.07e-204	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HFNEBIIC_01760	9.17e-59	-	-	-	-	-	-	-	-
HFNEBIIC_01762	9.29e-220	yjbO	5.4.99.23	-	G	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HFNEBIIC_01763	2.07e-196	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFNEBIIC_01764	7.45e-150	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
HFNEBIIC_01765	3.29e-146	yjbH	-	-	Q	-	-	-	Thioredoxin
HFNEBIIC_01766	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HFNEBIIC_01767	1.09e-251	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
HFNEBIIC_01768	3.67e-153	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HFNEBIIC_01769	2.87e-88	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HFNEBIIC_01770	5.33e-103	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
HFNEBIIC_01771	3.13e-15	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HFNEBIIC_01783	6.37e-90	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HFNEBIIC_01784	3.35e-59	-	-	-	S	-	-	-	Pfam:DUF59
HFNEBIIC_01785	2.82e-216	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFNEBIIC_01786	5.96e-139	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HFNEBIIC_01787	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HFNEBIIC_01788	7.1e-274	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HFNEBIIC_01789	2.37e-291	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFNEBIIC_01790	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HFNEBIIC_01791	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
HFNEBIIC_01792	5.45e-233	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
HFNEBIIC_01793	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HFNEBIIC_01794	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFNEBIIC_01795	1.81e-294	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HFNEBIIC_01796	9.28e-307	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HFNEBIIC_01797	4.2e-157	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
HFNEBIIC_01798	8.33e-230	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
HFNEBIIC_01799	3.82e-195	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
HFNEBIIC_01800	1.69e-120	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
HFNEBIIC_01801	4.45e-141	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HFNEBIIC_01802	1.45e-151	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_01803	3.32e-204	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
HFNEBIIC_01804	7.61e-288	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
HFNEBIIC_01805	1.92e-316	ymfH	-	-	S	-	-	-	Peptidase M16
HFNEBIIC_01806	3.1e-192	-	-	-	S	-	-	-	Helix-turn-helix domain
HFNEBIIC_01807	1.16e-133	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFNEBIIC_01808	1.95e-290	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
HFNEBIIC_01809	2.2e-251	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFNEBIIC_01810	2.29e-276	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
HFNEBIIC_01811	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HFNEBIIC_01812	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFNEBIIC_01813	1.02e-129	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HFNEBIIC_01814	3.34e-243	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HFNEBIIC_01815	1.98e-238	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HFNEBIIC_01816	7.17e-60	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HFNEBIIC_01817	2.15e-234	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HFNEBIIC_01818	0.0	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HFNEBIIC_01819	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFNEBIIC_01820	8.03e-58	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
HFNEBIIC_01821	3.62e-100	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFNEBIIC_01822	3.75e-63	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
HFNEBIIC_01823	1.44e-121	cvpA	-	-	S	-	-	-	Colicin V production protein
HFNEBIIC_01824	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HFNEBIIC_01825	2.86e-72	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HFNEBIIC_01826	1.67e-123	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
HFNEBIIC_01827	6.89e-189	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HFNEBIIC_01828	4.22e-136	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFNEBIIC_01829	9.54e-120	-	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
HFNEBIIC_01830	8.55e-99	ykuL	-	-	S	-	-	-	(CBS) domain
HFNEBIIC_01831	1.83e-196	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HFNEBIIC_01832	7.58e-189	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
HFNEBIIC_01833	8.88e-71	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HFNEBIIC_01834	1.38e-56	-	-	-	-	-	-	-	-
HFNEBIIC_01835	2.97e-267	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HFNEBIIC_01836	2.21e-231	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
HFNEBIIC_01837	9.05e-176	-	-	-	-	-	-	-	-
HFNEBIIC_01838	1.43e-167	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
HFNEBIIC_01839	4.67e-232	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
HFNEBIIC_01840	4.3e-233	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
HFNEBIIC_01841	6.31e-62	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	competence protein ComGC
HFNEBIIC_01842	2.12e-102	-	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	general secretion pathway protein
HFNEBIIC_01843	1.96e-55	-	-	-	-	-	-	-	-
HFNEBIIC_01844	1.88e-91	-	-	-	-	ko:K02248	-	ko00000,ko00002,ko02044	-
HFNEBIIC_01846	1.63e-182	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
HFNEBIIC_01847	4.36e-283	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFNEBIIC_01848	4.91e-143	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HFNEBIIC_01849	2.66e-120	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
HFNEBIIC_01850	4.76e-170	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HFNEBIIC_01851	1.7e-130	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
HFNEBIIC_01852	3.7e-149	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
HFNEBIIC_01853	6.8e-69	-	-	-	L	-	-	-	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
HFNEBIIC_01863	1.44e-146	frnE	5.3.4.1	-	Q	ko:K01829	-	ko00000,ko01000	DSBA-like thioredoxin domain
HFNEBIIC_01864	1.24e-209	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HFNEBIIC_01865	7.44e-27	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HFNEBIIC_01866	2.91e-46	-	-	-	S	-	-	-	Phage derived protein Gp49-like (DUF891)
HFNEBIIC_01868	1.37e-64	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
HFNEBIIC_01869	1.18e-193	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
HFNEBIIC_01870	5.8e-116	-	-	-	S	ko:K06889	-	ko00000	Hydrolases of the alpha beta superfamily
HFNEBIIC_01871	2.11e-43	-	-	-	S	ko:K06889	-	ko00000	Hydrolases of the alpha beta superfamily
HFNEBIIC_01872	2.56e-249	adhP	1.1.1.1	-	C	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
HFNEBIIC_01873	8.04e-101	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
HFNEBIIC_01874	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HFNEBIIC_01875	8.51e-143	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HFNEBIIC_01876	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFNEBIIC_01877	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFNEBIIC_01878	1.29e-260	-	-	-	-	-	-	-	-
HFNEBIIC_01879	8.83e-141	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type II secretory pathway prepilin signal peptidase PulO and related peptidases
HFNEBIIC_01880	2.51e-94	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFNEBIIC_01881	2.06e-108	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HFNEBIIC_01882	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HFNEBIIC_01883	7.44e-82	-	-	-	L	ko:K07487	-	ko00000	Transposase
HFNEBIIC_01884	2.59e-172	-	-	-	L	ko:K07487	-	ko00000	Transposase
HFNEBIIC_01885	1.48e-241	-	-	-	L	-	-	-	transposase IS116 IS110 IS902 family protein
HFNEBIIC_01886	1.28e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
HFNEBIIC_01887	5.45e-153	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HFNEBIIC_01888	6.64e-139	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
HFNEBIIC_01889	4.22e-60	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HFNEBIIC_01890	1.16e-203	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFNEBIIC_01891	5.72e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFNEBIIC_01892	4.36e-70	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HFNEBIIC_01893	9.81e-157	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFNEBIIC_01894	1.96e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HFNEBIIC_01895	5.49e-38	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
HFNEBIIC_01896	1.1e-55	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HFNEBIIC_01897	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFNEBIIC_01898	2.58e-65	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFNEBIIC_01899	7.42e-125	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFNEBIIC_01900	4.97e-40	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFNEBIIC_01901	1.54e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HFNEBIIC_01902	6.12e-123	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFNEBIIC_01903	5.03e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HFNEBIIC_01904	5.95e-112	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFNEBIIC_01905	8.44e-34	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
HFNEBIIC_01906	7.07e-92	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HFNEBIIC_01907	3.35e-305	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HFNEBIIC_01908	1.51e-159	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HFNEBIIC_01909	2.41e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFNEBIIC_01910	5.79e-21	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
HFNEBIIC_01911	2.19e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFNEBIIC_01912	1.62e-83	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HFNEBIIC_01913	3.63e-219	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFNEBIIC_01914	8.08e-83	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
HFNEBIIC_01915	2.08e-178	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFNEBIIC_01916	3.8e-194	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFNEBIIC_01917	2.89e-181	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFNEBIIC_01918	3.54e-181	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HFNEBIIC_01919	9.25e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HFNEBIIC_01920	1.61e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
HFNEBIIC_01921	1.49e-178	budC	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	reductase
HFNEBIIC_01922	4.18e-147	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
HFNEBIIC_01923	2.75e-130	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HFNEBIIC_01924	1.48e-268	purK2	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HFNEBIIC_01925	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
HFNEBIIC_01926	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFNEBIIC_01927	1.91e-261	camS	-	-	S	-	-	-	sex pheromone
HFNEBIIC_01928	5.55e-66	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFNEBIIC_01929	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HFNEBIIC_01930	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFNEBIIC_01931	1.91e-237	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
HFNEBIIC_01932	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFNEBIIC_01934	2.24e-46	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HFNEBIIC_01936	5.39e-88	-	-	-	S	-	-	-	Abortive infection C-terminus
HFNEBIIC_01937	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	associated with various cellular activities
HFNEBIIC_01938	2.49e-43	-	-	-	-	-	-	-	-
HFNEBIIC_01939	1.13e-272	-	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HFNEBIIC_01940	4.23e-222	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFNEBIIC_01941	6.86e-98	-	-	-	O	-	-	-	OsmC-like protein
HFNEBIIC_01944	4.6e-170	hisJ	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphatase and related hydrolases of the PHP family
HFNEBIIC_01945	1.79e-111	-	-	-	K	-	-	-	FR47-like protein
HFNEBIIC_01946	1.4e-68	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HFNEBIIC_01950	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HFNEBIIC_01951	6.35e-71	-	-	-	-	-	-	-	-
HFNEBIIC_01952	6.5e-271	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
HFNEBIIC_01953	3.99e-166	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HFNEBIIC_01954	1.36e-198	hlyD3	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFNEBIIC_01955	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HFNEBIIC_01956	1.01e-187	-	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFNEBIIC_01957	1.52e-192	-	-	-	E	-	-	-	Glyoxalase-like domain
HFNEBIIC_01958	1.39e-198	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
HFNEBIIC_01959	4.38e-288	dhaT	1.1.1.202	-	C	ko:K00086	ko00561,ko00640,map00561,map00640	ko00000,ko00001,ko01000	Dehydrogenase
HFNEBIIC_01960	9.06e-125	-	-	-	S	-	-	-	reductase
HFNEBIIC_01962	3.07e-114	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HFNEBIIC_01963	1.22e-224	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
HFNEBIIC_01964	1.47e-110	pgpA	-	-	I	-	-	-	Phosphatidylglycerophosphatase A
HFNEBIIC_01966	2.07e-283	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
HFNEBIIC_01967	2.52e-196	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
HFNEBIIC_01968	2.39e-191	yycI	-	-	S	-	-	-	YycH protein
HFNEBIIC_01969	1.09e-311	yycH	-	-	S	-	-	-	YycH protein
HFNEBIIC_01970	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HFNEBIIC_01971	1.29e-168	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HFNEBIIC_01973	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
HFNEBIIC_01974	2.57e-94	-	-	-	K	ko:K18909	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
HFNEBIIC_01976	7.1e-130	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
HFNEBIIC_01977	2.43e-206	-	-	-	S	-	-	-	Polyphosphate nucleotide phosphotransferase, PPK2 family
HFNEBIIC_01978	5.66e-313	aldA	1.2.1.21, 1.2.1.22	-	C	ko:K07248	ko00620,ko00630,ko01120,map00620,map00630,map01120	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family
HFNEBIIC_01979	1.32e-251	adhC	1.1.1.90	-	C	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Zn-dependent alcohol dehydrogenases, class III
HFNEBIIC_01980	1.89e-81	-	-	-	-	-	-	-	-
HFNEBIIC_01981	6.23e-268	yttB	-	-	EGP	-	-	-	Major Facilitator
HFNEBIIC_01982	7.36e-308	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HFNEBIIC_01983	1.25e-97	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HFNEBIIC_01984	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
HFNEBIIC_01985	9.36e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFNEBIIC_01986	1.34e-110	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HFNEBIIC_01987	4.55e-64	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
HFNEBIIC_01988	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFNEBIIC_01989	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFNEBIIC_01990	1.1e-257	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFNEBIIC_01991	2.58e-45	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
HFNEBIIC_01992	4.03e-263	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HFNEBIIC_01993	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HFNEBIIC_01994	7.96e-21	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
HFNEBIIC_01995	1.39e-76	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HFNEBIIC_01996	2.96e-172	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HFNEBIIC_01997	2.97e-168	jag	-	-	S	ko:K06346	-	ko00000	R3H domain protein
HFNEBIIC_01998	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HFNEBIIC_01999	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HFNEBIIC_02000	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HFNEBIIC_02001	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFNEBIIC_02002	1.73e-313	yxbA	6.3.1.12	-	S	ko:K17810	-	ko00000,ko01000	ATP-grasp enzyme
HFNEBIIC_02003	3.47e-147	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HFNEBIIC_02004	5.59e-20	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase, GNAT family
HFNEBIIC_02005	6.71e-61	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase, GNAT family
HFNEBIIC_02006	1.15e-93	-	-	-	L	-	-	-	PFAM Integrase catalytic region
HFNEBIIC_02007	3.25e-43	-	-	-	L	-	-	-	PFAM Integrase catalytic region
HFNEBIIC_02008	5.53e-84	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HFNEBIIC_02009	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HFNEBIIC_02010	6.68e-262	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HFNEBIIC_02011	0.0	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
HFNEBIIC_02012	3.48e-225	cytR	-	-	K	ko:K02529,ko:K03604	-	ko00000,ko03000	Transcriptional regulator, LacI family
HFNEBIIC_02013	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFNEBIIC_02014	3.33e-129	-	1.5.1.36	-	S	ko:K19784,ko:K22393	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	reductase
HFNEBIIC_02015	3.9e-270	-	1.5.1.36	-	S	ko:K19784,ko:K22393,ko:K22394	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	reductase
HFNEBIIC_02016	5.64e-225	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HFNEBIIC_02017	1.28e-35	-	-	-	L	ko:K07491	-	ko00000	PFAM transposase IS200-family protein
HFNEBIIC_02018	1.67e-45	-	-	-	L	-	-	-	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
HFNEBIIC_02019	0.0	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HFNEBIIC_02020	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HFNEBIIC_02021	3.28e-177	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HFNEBIIC_02022	2.51e-285	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HFNEBIIC_02023	1.97e-277	nupG	-	-	F	ko:K03317,ko:K11535,ko:K16323	-	ko00000,ko02000	Nucleoside transporter
HFNEBIIC_02024	4.78e-218	rihA	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
HFNEBIIC_02025	7.26e-209	-	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	3-hydroxyacyl-CoA dehydrogenase
HFNEBIIC_02026	1.36e-157	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
HFNEBIIC_02027	3.79e-193	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HFNEBIIC_02028	8.34e-180	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
HFNEBIIC_02029	8e-197	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HFNEBIIC_02030	2.37e-42	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
HFNEBIIC_02031	1.75e-254	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HFNEBIIC_02032	6.3e-175	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
HFNEBIIC_02033	9.74e-154	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFNEBIIC_02034	4.64e-298	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HFNEBIIC_02035	2.62e-299	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	pyrimidine-nucleoside phosphorylase
HFNEBIIC_02036	3.27e-167	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
HFNEBIIC_02037	6.51e-216	deoR	-	-	K	ko:K05346	-	ko00000,ko03000	sugar-binding domain protein
HFNEBIIC_02038	1.47e-265	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HFNEBIIC_02039	1.14e-159	vanR	-	-	K	-	-	-	response regulator
HFNEBIIC_02040	3.73e-264	hpk31	-	-	T	-	-	-	Histidine kinase
HFNEBIIC_02041	8e-185	-	-	-	E	-	-	-	AzlC protein
HFNEBIIC_02042	4.05e-70	-	-	-	S	-	-	-	branched-chain amino acid
HFNEBIIC_02043	1.08e-131	-	-	-	K	-	-	-	LysR substrate binding domain
HFNEBIIC_02044	2.57e-221	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
HFNEBIIC_02045	2.04e-311	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HFNEBIIC_02046	9.27e-219	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HFNEBIIC_02047	3.95e-167	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HFNEBIIC_02048	1.51e-147	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HFNEBIIC_02049	7.47e-148	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HFNEBIIC_02050	2.62e-122	ribB	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFNEBIIC_02051	7.79e-290	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
HFNEBIIC_02052	3.86e-223	ydbI	-	-	K	-	-	-	AI-2E family transporter
HFNEBIIC_02053	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
HFNEBIIC_02054	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HFNEBIIC_02055	1.62e-168	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Belongs to the alpha-acetolactate decarboxylase family
HFNEBIIC_02056	1.19e-27	rhaS4	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HFNEBIIC_02057	2.93e-231	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
HFNEBIIC_02058	1.47e-218	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
HFNEBIIC_02059	5.75e-126	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HFNEBIIC_02061	8.95e-110	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFNEBIIC_02062	5.01e-275	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFNEBIIC_02063	0.0	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFNEBIIC_02064	2.49e-168	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
HFNEBIIC_02065	7.76e-51	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFNEBIIC_02066	1.98e-163	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFNEBIIC_02067	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFNEBIIC_02068	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFNEBIIC_02069	1.95e-250	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
HFNEBIIC_02070	9.65e-135	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFNEBIIC_02071	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
HFNEBIIC_02072	4.57e-307	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
HFNEBIIC_02073	5.27e-169	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFNEBIIC_02074	1.12e-226	-	-	-	-	-	-	-	-
HFNEBIIC_02075	1.58e-301	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)