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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
PIKALECD_00001	6.36e-85	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid
PIKALECD_00002	2.44e-135	-	1.6.5.5	-	C	ko:K00344	-	ko00000,ko01000	Zinc-binding dehydrogenase
PIKALECD_00003	8.93e-153	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
PIKALECD_00004	1.29e-261	yycB1	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
PIKALECD_00005	1.17e-39	-	-	-	K	-	-	-	MerR, DNA binding
PIKALECD_00006	2.57e-96	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
PIKALECD_00007	5.89e-81	-	-	-	F	-	-	-	Cytidine and deoxycytidylate deaminase zinc-binding region
PIKALECD_00008	3.11e-21	-	-	-	V	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
PIKALECD_00009	3.32e-93	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00010	5.14e-179	-	3.4.16.4	-	V	ko:K01286	-	ko00000,ko01000	Beta-lactamase
PIKALECD_00011	1.92e-149	yybG	-	-	S	-	-	-	Pentapeptide repeat-containing protein
PIKALECD_00012	1.76e-58	ydhM	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_00013	2.06e-299	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PIKALECD_00014	2.1e-63	celC	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_00015	0.0	gmuD	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
PIKALECD_00016	0.0	licR	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
PIKALECD_00017	1.15e-76	-	-	-	K	-	-	-	TetR family transcriptional regulator
PIKALECD_00018	4.18e-135	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
PIKALECD_00019	1.27e-105	-	-	-	K	-	-	-	Bacterial transcription activator, effector binding domain
PIKALECD_00020	1.74e-110	-	-	-	-	-	-	-	-
PIKALECD_00021	8.17e-265	-	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Glycosyl hydrolase family 1
PIKALECD_00022	0.0	-	3.2.1.24	GH38	G	ko:K01191	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
PIKALECD_00023	1.25e-231	-	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 85
PIKALECD_00024	3.85e-312	-	2.3.1.204, 3.2.1.24	GH38	G	ko:K01191,ko:K16869	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Alpha mannosidase, middle domain
PIKALECD_00025	1.4e-236	-	-	-	S	ko:K09704	-	ko00000	Glycosyl hydrolase
PIKALECD_00026	2.93e-13	-	-	-	S	-	-	-	Protein of unknown function, DUF624
PIKALECD_00027	6.62e-149	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_00028	1.74e-123	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
PIKALECD_00029	1.36e-171	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00030	1.32e-169	ytcP	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00031	2.55e-256	ypcG	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_00032	4.26e-89	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
PIKALECD_00033	6.96e-125	-	-	-	M	-	-	-	3D domain
PIKALECD_00035	1.23e-281	-	-	-	JM	-	-	-	Bacterial transferase hexapeptide (six repeats)
PIKALECD_00036	1.23e-162	frlR3	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
PIKALECD_00037	3.29e-181	-	-	-	S	-	-	-	carbohydrate derivative metabolic process
PIKALECD_00038	3.82e-107	ykoG	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_00039	7.93e-306	ykoH	-	-	T	-	-	-	Histidine kinase
PIKALECD_00040	8.42e-152	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
PIKALECD_00041	1.38e-103	ykoJ	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
PIKALECD_00042	4.65e-150	-	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Glycerate kinase family
PIKALECD_00043	3.61e-130	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
PIKALECD_00045	0.0	-	-	-	I	-	-	-	radical SAM domain protein
PIKALECD_00046	0.0	-	1.3.98.3	-	H	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of porphyrin-containing compound
PIKALECD_00048	3.5e-170	yafE	-	-	Q	-	-	-	methyltransferase
PIKALECD_00050	2.9e-114	-	-	-	S	-	-	-	Uncharacterised protein family UPF0066
PIKALECD_00051	9.45e-281	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
PIKALECD_00052	3.91e-124	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PIKALECD_00053	1.41e-214	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	GDP-mannose 4,6 dehydratase
PIKALECD_00054	2.21e-228	-	-	-	M	-	-	-	Glycosyl transferases group 1
PIKALECD_00055	1.98e-197	-	-	-	-	-	-	-	-
PIKALECD_00056	2.8e-160	-	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	transferase activity, transferring glycosyl groups
PIKALECD_00057	4.21e-213	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
PIKALECD_00058	4.41e-148	-	-	-	M	-	-	-	Glycosyl transferase family 2
PIKALECD_00059	4.26e-292	-	1.1.1.136	-	M	ko:K13015	ko00520,map00520	ko00000,ko00001,ko01000,ko01005	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PIKALECD_00060	8.15e-250	-	-	-	M	-	-	-	Glycosyltransferase like family 2
PIKALECD_00061	1.07e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
PIKALECD_00062	2.58e-33	-	-	-	-	-	-	-	-
PIKALECD_00063	2.01e-306	VCP	-	-	O	-	-	-	AAA domain (dynein-related subfamily)
PIKALECD_00064	6.24e-119	ycsK	-	-	E	-	-	-	anatomical structure formation involved in morphogenesis
PIKALECD_00065	1.21e-164	-	-	-	K	-	-	-	helix_turn_helix isocitrate lyase regulation
PIKALECD_00066	1.78e-215	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
PIKALECD_00067	1.3e-136	-	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
PIKALECD_00068	8.16e-289	dgoD	4.2.1.6	-	M	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
PIKALECD_00069	8.06e-247	gntU	-	-	EG	ko:K03299,ko:K06156	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
PIKALECD_00070	1.99e-197	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
PIKALECD_00071	2.22e-112	-	-	-	S	-	-	-	Predicted membrane protein (DUF2243)
PIKALECD_00072	9.85e-159	-	-	-	S	ko:K02351	-	ko00000	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)
PIKALECD_00073	2.68e-293	-	2.7.13.3	-	T	ko:K02484	-	ko00000,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
PIKALECD_00074	4.84e-160	-	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_00075	2.17e-210	-	-	-	K	-	-	-	DJ-1/PfpI family
PIKALECD_00076	1.75e-141	-	-	-	S	-	-	-	Predicted membrane protein (DUF2306)
PIKALECD_00077	9.72e-254	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
PIKALECD_00078	1.11e-88	-	-	-	S	-	-	-	VanZ like family
PIKALECD_00079	1.92e-141	wrbA	1.6.5.2	-	S	ko:K03809	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Belongs to the WrbA family
PIKALECD_00080	8.65e-101	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
PIKALECD_00081	1.63e-161	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
PIKALECD_00082	0.0	-	-	-	V	-	-	-	SNF2 family N-terminal domain
PIKALECD_00085	0.0	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_00086	1.43e-112	-	-	-	-	-	-	-	-
PIKALECD_00087	2.72e-194	-	-	-	-	-	-	-	-
PIKALECD_00088	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
PIKALECD_00089	5.45e-29	-	-	-	-	-	-	-	-
PIKALECD_00090	1.93e-284	bbsF_2	2.8.3.16	-	C	ko:K07749	-	ko00000,ko01000	acyl-CoA transferases carnitine dehydratase
PIKALECD_00091	2.12e-144	-	-	-	K	-	-	-	FCD domain
PIKALECD_00092	2.95e-199	-	4.1.3.4	-	E	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA lyase
PIKALECD_00093	3.05e-265	-	-	-	G	-	-	-	Transmembrane secretion effector
PIKALECD_00094	2.51e-25	-	3.4.21.19	-	M	ko:K01318	ko02024,map02024	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S1B family
PIKALECD_00095	1.78e-284	hmrA	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
PIKALECD_00096	6.67e-202	metQ_3	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
PIKALECD_00097	3.91e-145	-	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
PIKALECD_00098	4.2e-241	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PIKALECD_00099	3.72e-214	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
PIKALECD_00101	0.0	xynB	3.2.1.37	GH43	G	ko:K01198	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
PIKALECD_00102	0.0	aguA	3.2.1.139	-	G	ko:K01235	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 67 family
PIKALECD_00103	3.12e-223	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00104	2.69e-197	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
PIKALECD_00105	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_00106	8.36e-145	-	-	-	S	-	-	-	Protein of unknown function, DUF624
PIKALECD_00107	1.94e-248	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
PIKALECD_00108	4.3e-43	-	-	-	D	-	-	-	nuclear chromosome segregation
PIKALECD_00110	3.27e-276	hutI	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
PIKALECD_00111	8.29e-252	-	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
PIKALECD_00112	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_00113	9.9e-216	-	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_00114	4.75e-192	-	-	-	EP	ko:K02034,ko:K13891	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_00115	3.73e-240	-	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_00116	3.03e-242	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_00117	7.64e-222	-	-	-	S	-	-	-	Protein of unknown function (DUF1177)
PIKALECD_00118	3.91e-307	yodQ	3.5.1.16, 3.5.1.18	-	E	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetylornithine deacetylase
PIKALECD_00119	4.63e-175	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00120	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
PIKALECD_00121	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	xylulose kinase
PIKALECD_00122	8.59e-249	mro	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Converts alpha-aldose to the beta-anomer
PIKALECD_00123	3.52e-274	xylR5	-	-	GK	-	-	-	ROK family
PIKALECD_00124	9.48e-157	-	-	-	S	ko:K09992	-	ko00000	Trehalose utilisation
PIKALECD_00125	1.46e-282	yrbE	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_00126	0.0	-	-	-	KT	ko:K09684	-	ko00000,ko03000	PucR C-terminal helix-turn-helix domain
PIKALECD_00127	6e-139	-	-	-	E	-	-	-	Asp/Glu/Hydantoin racemase
PIKALECD_00128	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
PIKALECD_00129	3.89e-243	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
PIKALECD_00130	5.51e-213	-	-	-	S	-	-	-	Protein of unknown function (DUF1177)
PIKALECD_00131	5.63e-145	-	-	-	E	ko:K14591	-	ko00000	AroM protein
PIKALECD_00132	7.02e-218	-	-	-	E	-	-	-	Thermophilic metalloprotease (M29)
PIKALECD_00133	2.11e-263	-	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
PIKALECD_00134	2.4e-42	-	5.3.2.6	-	S	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Tautomerase enzyme
PIKALECD_00135	7.42e-205	citS	2.7.13.3	-	T	ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
PIKALECD_00136	1.16e-85	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
PIKALECD_00137	9.44e-184	yflP	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
PIKALECD_00138	4.57e-63	-	-	-	S	ko:K07794	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctB family
PIKALECD_00139	9.77e-280	tctA	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
PIKALECD_00140	1.61e-256	chrA	-	-	P	ko:K07240	-	ko00000,ko02000	chromate transporter, chromate ion transporter
PIKALECD_00141	6.94e-59	M1-594	-	-	S	-	-	-	Thiamine-binding protein
PIKALECD_00142	0.0	yngI	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PIKALECD_00143	1.82e-309	-	-	-	-	-	-	-	-
PIKALECD_00145	5.75e-289	gntT	-	-	EG	-	-	-	gluconate transmembrane transporter activity
PIKALECD_00146	8.25e-182	-	2.7.1.196, 2.7.1.205	-	K	ko:K02760,ko:K20480	ko00500,ko02024,ko02060,map00500,map02024,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	sequence-specific DNA binding
PIKALECD_00147	7.18e-153	yflK	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00149	6.57e-274	yngJ	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
PIKALECD_00150	1.84e-316	yngH	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase
PIKALECD_00151	1.13e-40	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin carboxyl carrier protein
PIKALECD_00152	1.05e-165	yngF	-	-	I	-	-	-	Belongs to the enoyl-CoA hydratase isomerase family
PIKALECD_00153	0.0	yngE	-	-	I	-	-	-	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
PIKALECD_00155	1.38e-274	-	-	-	-	-	-	-	-
PIKALECD_00156	8.53e-102	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70, region 4
PIKALECD_00157	8.44e-262	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_00158	6.43e-204	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
PIKALECD_00159	2.94e-31	-	-	-	-	-	-	-	-
PIKALECD_00161	5.66e-258	yheB	-	-	S	-	-	-	Belongs to the UPF0754 family
PIKALECD_00162	2.8e-72	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
PIKALECD_00163	1.96e-199	yhaX	-	-	S	-	-	-	hydrolases of the HAD superfamily
PIKALECD_00165	9.93e-65	-	-	-	-	-	-	-	-
PIKALECD_00166	2.7e-161	cssR	-	-	T	ko:K07770	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_00167	0.0	cssS	2.7.13.3	-	T	ko:K07650	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_00168	4.85e-231	yhaM	-	-	L	ko:K03698	-	ko00000,ko01000,ko03019	Shows a 3'-5' exoribonuclease activity
PIKALECD_00169	1.88e-56	yhaL	-	-	S	-	-	-	Sporulation protein YhaL
PIKALECD_00170	5.14e-212	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
PIKALECD_00171	1.23e-06	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
PIKALECD_00172	5.87e-132	-	-	-	S	-	-	-	Protein conserved in bacteria
PIKALECD_00173	1.67e-140	hpr	-	-	K	ko:K09682	-	ko00000,ko03000	Negative regulator of protease production and sporulation
PIKALECD_00174	1.23e-66	yhaH	-	-	D	-	-	-	gas vesicle protein
PIKALECD_00175	4.71e-263	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PIKALECD_00176	5.23e-97	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
PIKALECD_00177	8.06e-177	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	transporter (ATP-binding protein)
PIKALECD_00178	1.35e-282	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_00179	4.46e-165	ecsC	-	-	S	-	-	-	EcsC protein family
PIKALECD_00180	1.59e-156	ccdA	-	-	O	ko:K06196	-	ko00000,ko02000	cytochrome c biogenesis protein
PIKALECD_00181	0.0	pbpF	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
PIKALECD_00182	5.06e-260	hemE	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PIKALECD_00183	2.93e-233	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
PIKALECD_00184	0.0	hemY	1.3.3.15, 1.3.3.4	-	H	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PIKALECD_00186	4.46e-132	spo0B	-	-	T	ko:K06375	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01000	Sporulation initiation phospho-transferase B, C-terminal
PIKALECD_00187	7.15e-295	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PIKALECD_00188	3.91e-95	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
PIKALECD_00189	1.11e-206	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
PIKALECD_00190	4.96e-118	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
PIKALECD_00191	5.12e-266	nifS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
PIKALECD_00192	0.0	nadB	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
PIKALECD_00193	4.42e-188	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NadC ModD family
PIKALECD_00194	5.5e-262	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PIKALECD_00195	6.86e-233	safA	-	-	M	ko:K06370	-	ko00000	spore coat assembly protein SafA
PIKALECD_00196	4.74e-25	-	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PIKALECD_00197	1.3e-82	-	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	cytochrome c oxidase subunit II
PIKALECD_00198	1.83e-112	bofC	-	-	S	ko:K06318	-	ko00000	BofC C-terminal domain
PIKALECD_00199	6.43e-133	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
PIKALECD_00200	6.39e-234	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
PIKALECD_00201	1.03e-37	yrzS	-	-	S	-	-	-	Protein of unknown function (DUF2905)
PIKALECD_00202	1.7e-238	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PIKALECD_00203	4.38e-289	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
PIKALECD_00204	1.58e-50	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit YajC
PIKALECD_00205	2.71e-76	yrzE	-	-	S	-	-	-	Protein of unknown function (DUF3792)
PIKALECD_00206	3.82e-94	-	-	-	S	-	-	-	membrane
PIKALECD_00207	7.4e-41	yodI	-	-	-	-	-	-	-
PIKALECD_00208	0.0	spoVB	-	-	S	ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PIKALECD_00209	9.5e-30	yrzD	-	-	S	-	-	-	Post-transcriptional regulator
PIKALECD_00210	6.1e-294	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PIKALECD_00211	3.84e-192	secF	-	-	U	ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PIKALECD_00212	5.69e-50	yrvD	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
PIKALECD_00213	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
PIKALECD_00214	1.64e-119	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PIKALECD_00215	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PIKALECD_00216	1.26e-95	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
PIKALECD_00217	5.25e-234	-	-	-	K	-	-	-	LacI family transcriptional regulator
PIKALECD_00218	1.07e-183	thuA	-	-	G	-	-	-	Trehalose utilisation
PIKALECD_00219	8.24e-248	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_00220	4.71e-256	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the UPF0214 family
PIKALECD_00222	5.57e-307	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
PIKALECD_00223	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PIKALECD_00224	2.48e-272	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
PIKALECD_00225	5.89e-66	-	-	-	-	-	-	-	-
PIKALECD_00226	2.51e-251	-	-	-	EGP	-	-	-	the major facilitator superfamily
PIKALECD_00227	5.35e-77	-	-	-	K	-	-	-	TetR family transcriptional regulator
PIKALECD_00228	2.37e-274	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
PIKALECD_00229	2.48e-176	yrvM	-	-	H	ko:K22132	-	ko00000,ko03016	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
PIKALECD_00230	3.15e-138	rsfA	-	-	S	ko:K06314	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_00231	4.47e-294	rarA	-	-	L	ko:K07478	-	ko00000	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
PIKALECD_00232	8.4e-93	cymR	-	-	K	ko:K17472	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_00233	1.04e-268	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
PIKALECD_00234	1.05e-275	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
PIKALECD_00235	5.69e-81	yrrB	-	-	S	-	-	-	COG0457 FOG TPR repeat
PIKALECD_00236	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
PIKALECD_00237	1.1e-103	yrrD	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00238	1.11e-41	yrzR	-	-	-	-	-	-	-
PIKALECD_00239	3.8e-234	yrrI	-	-	S	-	-	-	AI-2E family transporter
PIKALECD_00240	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PIKALECD_00241	1.32e-57	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
PIKALECD_00242	9e-94	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PIKALECD_00243	2.04e-43	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
PIKALECD_00244	6.73e-266	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PIKALECD_00245	3.15e-146	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-methyltransferase
PIKALECD_00246	4.67e-147	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
PIKALECD_00247	2.58e-103	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
PIKALECD_00248	6.64e-17	yrrS	-	-	S	-	-	-	Protein of unknown function (DUF1510)
PIKALECD_00249	0.0	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
PIKALECD_00250	1.44e-191	ku	-	-	L	ko:K10979	ko03450,map03450	ko00000,ko00001,ko03400	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PIKALECD_00251	2.39e-158	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PIKALECD_00253	2.44e-99	-	-	-	-	-	-	-	-
PIKALECD_00254	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
PIKALECD_00255	7.98e-188	-	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
PIKALECD_00256	1.43e-181	-	-	-	P	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
PIKALECD_00257	3.7e-204	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
PIKALECD_00258	6.73e-194	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00259	9.47e-137	arpR	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_00260	0.0	-	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Starch/carbohydrate-binding module (family 53)
PIKALECD_00261	5.33e-73	-	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PIKALECD_00262	1.51e-136	XK27_06885	-	-	L	-	-	-	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
PIKALECD_00263	5.5e-238	lplJ	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
PIKALECD_00264	0.0	-	-	-	S	-	-	-	Membrane
PIKALECD_00265	2.33e-283	hipO3	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
PIKALECD_00266	2.57e-206	ybaS	-	-	S	-	-	-	Na -dependent transporter
PIKALECD_00267	7.36e-159	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_00268	2.8e-36	-	-	-	P	-	-	-	Transporter associated domain
PIKALECD_00269	1.89e-107	-	-	-	P	-	-	-	Transporter associated domain
PIKALECD_00270	1.11e-34	-	-	-	-	-	-	-	-
PIKALECD_00273	9.47e-70	-	-	-	-	-	-	-	-
PIKALECD_00274	2.72e-300	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
PIKALECD_00275	0.0	nasD	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PIKALECD_00276	5.08e-72	nirD	1.7.1.15	-	P	ko:K00363	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite reductase
PIKALECD_00277	0.0	nirB	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PIKALECD_00278	0.0	nasC	-	-	C	ko:K00372	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PIKALECD_00279	1.51e-280	nasA	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
PIKALECD_00280	0.0	-	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
PIKALECD_00282	9.77e-191	thiD	2.5.1.3, 2.7.1.49, 2.7.4.7	-	H	ko:K00941,ko:K14153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
PIKALECD_00283	5.78e-57	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
PIKALECD_00284	1.13e-81	-	-	-	P	ko:K05571	-	ko00000,ko02000	Na+/H+ antiporter subunit
PIKALECD_00285	4.41e-52	-	-	-	P	ko:K05570	-	ko00000,ko02000	Multiple resistance and pH regulation protein F (MrpF / PhaF)
PIKALECD_00286	8.91e-106	mrpE	-	-	P	ko:K05569	-	ko00000,ko02000	Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_00287	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_00288	1.13e-66	mnhC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_00289	5.81e-91	mrpB	-	-	P	ko:K05566	-	ko00000,ko02000	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_00290	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
PIKALECD_00292	1.52e-125	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
PIKALECD_00293	8.93e-272	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
PIKALECD_00294	2.58e-188	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PIKALECD_00295	5.33e-63	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein containing KH domain, possibly ribosomal protein
PIKALECD_00296	2.36e-136	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PIKALECD_00297	1.36e-136	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
PIKALECD_00298	7.46e-81	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
PIKALECD_00299	6.7e-205	yitL	-	-	S	ko:K00243	-	ko00000	protein conserved in bacteria
PIKALECD_00300	1.97e-173	-	-	-	S	-	-	-	Methyltransferase domain
PIKALECD_00301	1.38e-188	comER	-	-	E	ko:K02239	-	ko00000,ko00002,ko02044	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PIKALECD_00302	2.48e-128	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
PIKALECD_00303	9.98e-140	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
PIKALECD_00304	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
PIKALECD_00305	9.62e-09	-	-	-	S	-	-	-	YqzM-like protein
PIKALECD_00306	1.6e-226	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
PIKALECD_00307	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PIKALECD_00308	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PIKALECD_00309	3.78e-156	glpF	-	-	G	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
PIKALECD_00310	1.61e-250	-	-	-	G	ko:K10240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 1
PIKALECD_00311	5.35e-200	araP	-	-	P	ko:K10189,ko:K10241,ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_00312	2.47e-184	-	-	-	P	ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_00313	7e-243	cytR	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
PIKALECD_00314	0.0	-	-	-	M	-	-	-	glycoside hydrolase family 81
PIKALECD_00315	6.5e-146	-	-	-	S	-	-	-	Cupin
PIKALECD_00316	1.08e-46	-	-	-	-	-	-	-	-
PIKALECD_00317	3.99e-07	liaI	-	-	-	ko:K11619	ko02020,map02020	ko00000,ko00001,ko00002	-
PIKALECD_00318	3.76e-132	-	-	-	-	-	-	-	-
PIKALECD_00319	1.36e-156	yvqF	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
PIKALECD_00320	1.32e-232	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_00321	2.22e-138	vraR	-	-	KT	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PIKALECD_00322	4.74e-139	modB	-	-	P	ko:K02018	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4149 ABC-type molybdate transport system, permease component
PIKALECD_00323	3.76e-166	modA	-	-	P	ko:K02020	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0725 ABC-type molybdate transport system, periplasmic component
PIKALECD_00324	3.81e-179	araR	-	-	K	ko:K02103	-	ko00000,ko03000	transcriptional
PIKALECD_00325	5.04e-221	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_00326	4.6e-165	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	ABC transporter permease
PIKALECD_00327	1.76e-160	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_00328	1.02e-42	-	-	-	-	-	-	-	-
PIKALECD_00329	0.0	xsa	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	Alpha-L-arabinofuranosidase C-terminus
PIKALECD_00330	8.01e-35	-	-	-	-	-	-	-	-
PIKALECD_00331	0.0	yxiA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
PIKALECD_00332	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
PIKALECD_00333	2.75e-174	-	-	-	S	ko:K06976	-	ko00000	GNAT acetyltransferase
PIKALECD_00334	1.1e-185	tagG	-	-	GM	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
PIKALECD_00335	2.24e-227	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
PIKALECD_00336	5.72e-69	yvdC	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
PIKALECD_00337	1.45e-56	M1-485	-	-	S	-	-	-	Membrane
PIKALECD_00338	1.81e-251	ysdC_3	3.2.1.4	GH5,GH9	G	ko:K01179	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	M42 glutamyl aminopeptidase
PIKALECD_00339	1.77e-43	-	-	-	S	-	-	-	NAD(P)H-dependent FMN reductase
PIKALECD_00340	1.01e-104	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PIKALECD_00341	1.22e-70	-	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	TIGRFAM glutamine amidotransferase of anthranilate synthase
PIKALECD_00342	1.23e-07	-	-	-	CG	-	-	-	UDP-glucoronosyl and UDP-glucosyl transferase
PIKALECD_00343	6.63e-71	-	-	-	S	-	-	-	PFAM Glycosyl transferase family 2
PIKALECD_00344	4.52e-77	-	-	-	EGP	-	-	-	Major facilitator superfamily
PIKALECD_00345	2.95e-99	-	-	-	-	-	-	-	-
PIKALECD_00346	1.89e-95	-	-	-	-	-	-	-	-
PIKALECD_00347	1.4e-69	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
PIKALECD_00348	1.82e-229	regR	-	-	K	ko:K02525	-	ko00000,ko03000	transcriptional
PIKALECD_00349	1.98e-233	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_00350	9.62e-111	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_00351	4.94e-262	siaT_3	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
PIKALECD_00352	1.94e-117	hxlB	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
PIKALECD_00353	2.26e-145	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PIKALECD_00354	8.92e-221	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
PIKALECD_00355	6.07e-133	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	3-hexulose-6-phosphate synthase
PIKALECD_00356	3.45e-240	-	-	-	-	-	-	-	-
PIKALECD_00358	0.0	zosA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
PIKALECD_00359	0.0	-	-	-	GKT	-	-	-	COG3711 Transcriptional antiterminator
PIKALECD_00360	9.41e-94	-	2.7.1.200	-	GT	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_00361	2.12e-56	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_00362	3.47e-286	gatC	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	COG3775 Phosphotransferase system, galactitol-specific IIC component
PIKALECD_00363	4.25e-248	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
PIKALECD_00364	1.15e-29	-	-	-	-	-	-	-	-
PIKALECD_00365	8.17e-267	gatD	1.1.1.14, 1.1.1.251	-	C	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	ko00000,ko00001,ko00002,ko01000	Alcohol dehydrogenase GroES-like domain
PIKALECD_00366	0.0	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
PIKALECD_00368	1.69e-58	-	-	-	-	-	-	-	-
PIKALECD_00369	4.19e-116	ydhK	-	-	M	-	-	-	Protein of unknown function (DUF1541)
PIKALECD_00370	2.47e-222	-	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
PIKALECD_00371	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
PIKALECD_00372	1.76e-196	-	-	-	K	ko:K03488	-	ko00000,ko03000	antiterminator
PIKALECD_00373	1.09e-142	-	-	-	-	-	-	-	-
PIKALECD_00374	2.72e-135	desR	-	-	K	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
PIKALECD_00375	4.49e-236	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_00376	7.74e-279	-	-	-	G	-	-	-	Transmembrane secretion effector
PIKALECD_00377	0.0	-	-	-	T	-	-	-	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
PIKALECD_00378	0.0	hutU	4.2.1.49	-	E	ko:K01712	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PIKALECD_00379	2.12e-308	hutI	3.5.2.7	-	Q	ko:K01468	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Imidazolone-5-propionate hydrolase
PIKALECD_00380	4.72e-275	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
PIKALECD_00381	0.0	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
PIKALECD_00382	4.31e-296	-	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00383	5.64e-229	-	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
PIKALECD_00385	4.49e-114	-	-	-	-	-	-	-	-
PIKALECD_00386	1.81e-57	-	-	-	S	ko:K06361,ko:K06365,ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
PIKALECD_00387	3.8e-208	ydhJ	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
PIKALECD_00388	5.62e-75	-	-	-	FG	ko:K02503	-	ko00000,ko04147	HIT domain
PIKALECD_00389	2.02e-124	-	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	Protein kinase domain
PIKALECD_00390	4.68e-104	-	-	-	S	ko:K06385	-	ko00000	Stage II sporulation protein P (SpoIIP)
PIKALECD_00391	2.25e-174	-	-	-	K	-	-	-	acetyltransferase
PIKALECD_00392	5.07e-134	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_00393	1.22e-275	-	-	-	F	ko:K10974	-	ko00000,ko02000	cytosine purines uracil thiamine allantoin
PIKALECD_00394	1.2e-260	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
PIKALECD_00395	0.0	apc3	-	-	EQ	-	-	-	Hydantoinase/oxoprolinase
PIKALECD_00396	4.94e-36	-	-	-	-	-	-	-	-
PIKALECD_00397	7.73e-147	ypgQ	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
PIKALECD_00398	5.66e-295	-	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
PIKALECD_00399	2.99e-116	ywmF	-	-	S	-	-	-	Peptidase M50
PIKALECD_00400	2.15e-48	ydaS	-	-	S	-	-	-	membrane
PIKALECD_00402	2.43e-111	M1-753	-	-	M	-	-	-	FR47-like protein
PIKALECD_00403	1.19e-122	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_00404	1.42e-149	-	-	-	E	-	-	-	AzlC protein
PIKALECD_00405	3.91e-305	-	-	-	G	ko:K10188	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_00406	9.42e-203	-	-	-	G	ko:K10189	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00407	3.03e-190	araQ	-	-	P	ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_00408	1.34e-40	yisX	-	-	S	-	-	-	Pentapeptide repeats (9 copies)
PIKALECD_00409	3.26e-200	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
PIKALECD_00410	4.96e-104	-	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
PIKALECD_00411	2.17e-112	-	-	-	K	ko:K11922	-	ko00000,ko03000	Regulates the succiny-lCoA synthetase operon
PIKALECD_00412	9.08e-294	ptsG	2.7.1.199, 2.7.1.208	-	G	ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
PIKALECD_00413	9.93e-259	-	-	-	P	-	-	-	Sulfatase
PIKALECD_00414	8.69e-61	ptbA	2.7.1.199	-	G	ko:K02777,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, glucose subfamily, IIA
PIKALECD_00415	8.46e-131	-	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Putative N-acetylmannosamine-6-phosphate epimerase
PIKALECD_00416	1.05e-156	-	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
PIKALECD_00417	2.07e-139	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_00418	3.96e-192	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
PIKALECD_00419	1.67e-86	-	-	-	E	ko:K07032	-	ko00000	lactoylglutathione lyase activity
PIKALECD_00420	0.0	-	-	-	M	-	-	-	Sulfatase
PIKALECD_00421	0.0	-	-	-	E	-	-	-	Aminotransferase class-V
PIKALECD_00422	9.27e-115	plsY1	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
PIKALECD_00423	3.94e-134	-	-	-	V	-	-	-	Beta-lactamase
PIKALECD_00424	6.02e-193	yfhB	-	-	S	-	-	-	PhzF family
PIKALECD_00425	4.05e-09	yqjY	-	-	K	ko:K06977	-	ko00000	acetyltransferase
PIKALECD_00426	7.88e-128	ydfF	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
PIKALECD_00427	2.51e-85	-	-	-	S	-	-	-	DinB superfamily
PIKALECD_00428	5.5e-80	-	-	-	S	-	-	-	Protein of unknown function, DUF393
PIKALECD_00429	1.03e-240	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_00430	1.95e-220	-	-	-	K	-	-	-	Cupin domain
PIKALECD_00431	1.57e-180	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_00432	1.42e-267	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_00433	0.0	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
PIKALECD_00434	3.23e-219	ugpA7	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00435	6.94e-199	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00436	2.22e-182	inoDHR	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_00437	2.18e-132	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_00438	6.73e-267	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_00439	1.46e-284	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_00440	3.62e-213	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_00441	2.34e-272	-	3.2.1.180	GH88	O	ko:K18581	-	ko00000,ko01000	Glycosyl Hydrolase Family 88
PIKALECD_00442	1.46e-208	-	-	-	G	-	-	-	Binding-protein-dependent transport system inner membrane component
PIKALECD_00443	1.05e-190	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00444	0.0	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
PIKALECD_00445	1.3e-146	-	-	-	M	-	-	-	Peptidase family M23
PIKALECD_00446	5.27e-77	-	-	-	S	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_00447	4.67e-116	mutT	3.6.1.13, 3.6.1.55	-	L	ko:K01515,ko:K03574	ko00230,map00230	ko00000,ko00001,ko01000,ko03400	nUDIX hydrolase
PIKALECD_00448	2.24e-88	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
PIKALECD_00449	9.5e-99	-	-	-	F	-	-	-	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PIKALECD_00451	3.84e-233	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
PIKALECD_00453	1.79e-131	-	-	-	-	-	-	-	-
PIKALECD_00454	9.03e-256	-	-	-	E	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_00455	1.39e-200	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00456	2.42e-206	-	-	-	G	ko:K02025,ko:K17238	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00457	2.98e-315	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_00458	0.0	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
PIKALECD_00459	2.95e-29	-	-	-	K	-	-	-	sequence-specific DNA binding
PIKALECD_00460	8.83e-69	-	-	-	K	-	-	-	sequence-specific DNA binding
PIKALECD_00461	3.74e-204	-	-	-	S	-	-	-	NYN domain
PIKALECD_00462	1.63e-158	-	-	-	-	-	-	-	-
PIKALECD_00464	1.51e-82	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
PIKALECD_00465	8.03e-160	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_00466	1.58e-176	-	-	-	-	-	-	-	-
PIKALECD_00468	1.39e-142	-	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	2-dehydro-3-deoxy-phosphogluconate aldolase
PIKALECD_00469	9.84e-181	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
PIKALECD_00470	1.2e-111	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00471	2.35e-142	yrzF	-	-	KLT	-	-	-	serine threonine protein kinase
PIKALECD_00472	6.45e-12	-	-	-	-	-	-	-	-
PIKALECD_00473	2.56e-50	-	-	-	-	-	-	-	-
PIKALECD_00474	3.28e-257	yhcY	2.7.13.3	-	T	ko:K02480	-	ko00000,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_00475	1.61e-145	yhcZ	-	-	K	ko:K02479	-	ko00000,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PIKALECD_00477	4.53e-238	-	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PIKALECD_00478	4.28e-164	-	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
PIKALECD_00479	2.77e-128	-	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
PIKALECD_00480	5.27e-207	yobV	-	-	K	-	-	-	WYL domain
PIKALECD_00481	1.21e-114	dinB	-	-	S	-	-	-	DinB family
PIKALECD_00482	1.99e-195	yxeH	-	-	S	-	-	-	hydrolases of the HAD superfamily
PIKALECD_00483	1.74e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PIKALECD_00484	5.16e-272	-	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_00485	9.02e-228	alkA	3.2.2.21	-	L	ko:K01247,ko:K13529	ko03410,map03410	ko00000,ko00001,ko01000,ko03000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PIKALECD_00486	8.4e-149	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
PIKALECD_00487	7.74e-121	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PIKALECD_00488	3.21e-28	-	-	-	-	-	-	-	-
PIKALECD_00489	3.8e-12	-	-	-	-	-	-	-	-
PIKALECD_00501	3.78e-154	-	-	-	UW	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
PIKALECD_00502	4.16e-69	-	-	-	UW	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
PIKALECD_00507	2.83e-63	-	-	-	L	ko:K07491	-	ko00000	transposase
PIKALECD_00508	4.47e-223	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_00509	2.03e-224	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_00510	1.49e-234	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
PIKALECD_00511	7.15e-178	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
PIKALECD_00512	1.16e-88	-	-	-	-	-	-	-	-
PIKALECD_00513	0.0	tuaD	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PIKALECD_00514	1.2e-279	-	-	-	M	-	-	-	-O-antigen
PIKALECD_00515	3.26e-70	-	-	-	-	-	-	-	-
PIKALECD_00516	1.1e-256	-	-	-	M	-	-	-	Glycosyl transferases group 1
PIKALECD_00517	6.37e-189	-	-	-	S	-	-	-	Glycosyl transferase family 2
PIKALECD_00518	0.0	-	-	-	S	-	-	-	Polysaccharide biosynthesis protein
PIKALECD_00519	2.5e-147	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00520	5.72e-144	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Iron/manganese superoxide dismutases, C-terminal domain
PIKALECD_00521	2.71e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF1450)
PIKALECD_00522	1.82e-41	-	-	-	C	-	-	-	4Fe-4S binding domain
PIKALECD_00523	4.05e-88	-	-	-	S	ko:K09957	-	ko00000	Putative glycolipid-binding
PIKALECD_00524	7.53e-302	-	-	-	S	ko:K12940	-	ko00000,ko01002	Peptidase dimerisation domain
PIKALECD_00525	0.0	-	-	-	H	ko:K12942	-	ko00000	AbgT putative transporter family
PIKALECD_00526	0.0	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	amidohydrolase
PIKALECD_00527	2.74e-302	-	-	-	KT	-	-	-	transcriptional regulatory protein
PIKALECD_00528	3.41e-187	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	Eukaryotic-type carbonic anhydrase
PIKALECD_00529	4.5e-260	thrCA	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
PIKALECD_00531	6.55e-109	-	-	-	M	ko:K01993	-	ko00000	PFAM secretion protein HlyD family protein
PIKALECD_00532	3.79e-176	ybhF_2	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
PIKALECD_00533	1.44e-244	ybhR	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
PIKALECD_00534	1e-147	ycfA	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00535	6.82e-86	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Chalcone and stilbene synthases, N-terminal domain
PIKALECD_00536	1.03e-129	ywqN_1	-	-	S	-	-	-	NAD(P)H-dependent
PIKALECD_00537	2.27e-188	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_00538	1.26e-10	tlp	-	-	S	ko:K06434	-	ko00000	spore protein
PIKALECD_00541	1.04e-110	ltrC	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phosphatidylglycerophosphatase A
PIKALECD_00542	4.02e-108	-	-	-	-	-	-	-	-
PIKALECD_00543	3.57e-202	kbaY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
PIKALECD_00544	9.17e-100	fruD	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_00545	0.0	fruC	2.7.1.202	-	G	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_00546	3.94e-221	fruK-1	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
PIKALECD_00547	6.56e-182	rpl	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
PIKALECD_00548	4.38e-211	XK27_03180	-	-	T	-	-	-	Belongs to the universal stress protein A family
PIKALECD_00550	1.63e-63	-	-	-	-	-	-	-	-
PIKALECD_00551	1.49e-74	-	-	-	-	-	-	-	-
PIKALECD_00552	7.08e-250	-	-	-	E	ko:K02055	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0687 Spermidine putrescine-binding periplasmic protein
PIKALECD_00553	3.33e-213	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
PIKALECD_00554	1.26e-178	-	-	-	E	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1176 ABC-type spermidine putrescine transport system, permease component I
PIKALECD_00555	3.46e-171	potC3	-	-	P	ko:K02053	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00556	7.35e-249	potA11	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
PIKALECD_00557	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Adenine deaminase C-terminal domain
PIKALECD_00558	0.0	M1-554	-	-	G	-	-	-	Endonuclease Exonuclease Phosphatase
PIKALECD_00559	8.68e-18	-	-	-	S	-	-	-	Inner spore coat protein D
PIKALECD_00560	9.91e-80	-	-	-	FJ	-	-	-	tRNA wobble adenosine to inosine editing
PIKALECD_00561	4.31e-199	-	-	-	P	ko:K02026,ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_00562	2.7e-201	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00563	1.96e-291	-	-	-	G	-	-	-	ABC transporter substrate-binding protein
PIKALECD_00564	9.11e-236	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
PIKALECD_00565	0.0	ltaS	2.7.8.20	-	M	ko:K01138,ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
PIKALECD_00566	5.1e-163	lacR	-	-	K	ko:K02530	-	ko00000,ko03000	DeoR C terminal sensor domain
PIKALECD_00567	7.81e-283	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PIKALECD_00568	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
PIKALECD_00569	4.39e-218	-	-	-	Q	-	-	-	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PIKALECD_00570	1.21e-54	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
PIKALECD_00574	6.07e-40	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
PIKALECD_00575	1.05e-132	-	-	-	C	-	-	-	lyase activity
PIKALECD_00576	4.76e-11	-	-	-	S	ko:K06936	-	ko00000	Elongator protein 3, MiaB family, Radical SAM
PIKALECD_00577	0.0	mdr	-	-	EGP	-	-	-	the major facilitator superfamily
PIKALECD_00578	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
PIKALECD_00579	2.1e-214	gmuE	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	COG1940 Transcriptional regulator sugar kinase
PIKALECD_00580	4.37e-65	-	-	-	-	-	-	-	-
PIKALECD_00581	4.95e-32	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	Capsular polysaccharide biosynthesis protein
PIKALECD_00582	4.85e-169	yvcP	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_00583	5.13e-244	yvcQ	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
PIKALECD_00584	6.34e-181	yxdL_2	-	-	V	ko:K02003,ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_00585	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
PIKALECD_00587	0.0	-	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
PIKALECD_00588	1.38e-198	-	-	-	S	-	-	-	CAAX amino terminal protease family protein
PIKALECD_00589	4.05e-215	-	-	-	K	-	-	-	Putative sugar-binding domain
PIKALECD_00590	1.1e-78	-	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
PIKALECD_00591	4.14e-232	-	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol sorbitol-specific transporter subunit IIB
PIKALECD_00592	8.78e-115	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
PIKALECD_00593	5.46e-89	-	-	-	K	-	-	-	Glucitol operon activator protein (GutM)
PIKALECD_00594	1.24e-299	-	-	-	E	-	-	-	SAF
PIKALECD_00595	4.83e-50	-	-	-	G	-	-	-	PTS HPr component phosphorylation site
PIKALECD_00596	4.73e-150	-	-	-	-	-	-	-	-
PIKALECD_00597	8.3e-123	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
PIKALECD_00598	1.37e-191	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Peptidase family M48
PIKALECD_00599	2.9e-292	avtA	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PIKALECD_00600	0.0	yknV	-	-	V	ko:K02021,ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_00601	0.0	yknU	-	-	V	ko:K06147,ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_00602	0.0	spoVR	-	-	S	ko:K06415	-	ko00000	Stage V sporulation protein R
PIKALECD_00603	0.0	pgcA	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
PIKALECD_00604	0.0	-	1.1.5.3	-	C	ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
PIKALECD_00605	1.61e-156	sfsA	-	-	S	ko:K06206	-	ko00000	Sugar fermentation stimulation protein
PIKALECD_00606	0.0	yhcX	-	-	K	-	-	-	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
PIKALECD_00608	8.67e-171	yqiK	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
PIKALECD_00609	7.18e-145	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
PIKALECD_00610	3.27e-278	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
PIKALECD_00611	1.18e-162	-	1.5.1.39	-	C	ko:K10678,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	ko00000,ko00001,ko01000	Oxidoreductase
PIKALECD_00612	5.38e-167	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
PIKALECD_00613	2.6e-278	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PIKALECD_00614	5.65e-170	yvoA	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
PIKALECD_00615	1.3e-204	ydaD	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_00616	0.0	-	-	-	G	ko:K10297	-	ko00000,ko04121	Right handed beta helix region
PIKALECD_00617	2.91e-104	-	-	-	S	-	-	-	Protein of unknown function (DUF664)
PIKALECD_00619	6.07e-189	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
PIKALECD_00620	6.26e-222	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
PIKALECD_00621	0.0	-	-	-	EGP	-	-	-	the major facilitator superfamily
PIKALECD_00622	9.24e-200	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_00625	4.51e-281	yhbH	-	-	S	ko:K09786	-	ko00000	Belongs to the UPF0229 family
PIKALECD_00626	4.66e-177	cysA1	-	-	S	-	-	-	AAA domain
PIKALECD_00627	4.26e-131	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
PIKALECD_00628	4.45e-100	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
PIKALECD_00629	0.0	prkA	-	-	T	ko:K07180	-	ko00000	Ser protein kinase
PIKALECD_00630	0.0	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
PIKALECD_00631	1.12e-69	-	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
PIKALECD_00632	1.46e-113	yufK	-	-	S	-	-	-	Family of unknown function (DUF5366)
PIKALECD_00633	7.16e-114	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
PIKALECD_00634	9.22e-213	yhbB	-	-	S	-	-	-	Putative amidase domain
PIKALECD_00635	3.57e-103	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_00636	1.29e-118	ogt	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PIKALECD_00637	6.87e-277	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PIKALECD_00638	7.09e-125	yhzB	-	-	S	-	-	-	B3/4 domain
PIKALECD_00639	5.28e-105	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
PIKALECD_00640	1.54e-249	yhfE	-	-	G	-	-	-	peptidase M42
PIKALECD_00641	2.42e-143	-	-	-	-	-	-	-	-
PIKALECD_00642	1.04e-152	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
PIKALECD_00643	1.81e-80	yhcF	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_00644	7.24e-163	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
PIKALECD_00645	2.64e-213	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_00646	4.33e-196	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
PIKALECD_00647	0.0	sacA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
PIKALECD_00648	0.0	bglC1	3.2.1.21, 3.2.1.52	GH3	G	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
PIKALECD_00649	0.0	scrA5	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_00650	2.57e-174	pamO	-	-	P	ko:K07222	-	ko00000	Flavin-binding monooxygenase-like
PIKALECD_00651	2.58e-15	pamO	-	-	P	ko:K07222	-	ko00000	Flavin-binding monooxygenase-like
PIKALECD_00652	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_00653	4.21e-116	-	-	-	-	-	-	-	-
PIKALECD_00654	0.0	cstA	-	-	T	ko:K06200	-	ko00000	Carbon starvation protein
PIKALECD_00655	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PIKALECD_00656	5.22e-231	yccF	-	-	K	ko:K07039	-	ko00000	SEC-C motif
PIKALECD_00657	1.92e-64	-	-	-	S	-	-	-	Regulatory protein YrvL
PIKALECD_00658	0.0	yfkN	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01081,ko:K06931,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
PIKALECD_00659	0.0	-	-	-	P	ko:K06901	-	ko00000,ko02000	secondary active sulfate transmembrane transporter activity
PIKALECD_00660	1.29e-133	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
PIKALECD_00661	3.13e-62	-	-	-	-	-	-	-	-
PIKALECD_00662	7.47e-123	p20	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_00663	2.68e-161	-	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
PIKALECD_00664	3.88e-189	adcA	-	-	P	ko:K09815,ko:K09818	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
PIKALECD_00665	1.08e-83	yxjI	-	-	S	-	-	-	LURP-one-related
PIKALECD_00666	1.26e-184	gspA	-	-	M	-	-	-	Glycosyl transferase family 8
PIKALECD_00667	1.19e-240	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
PIKALECD_00668	1.65e-271	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
PIKALECD_00669	6.26e-218	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
PIKALECD_00670	1.38e-137	-	-	-	KT	-	-	-	LuxR family transcriptional regulator
PIKALECD_00671	5.44e-241	-	-	-	T	-	-	-	Signal transduction histidine kinase
PIKALECD_00672	6.19e-124	-	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Phosphoglycerate mutase family
PIKALECD_00673	5.45e-146	-	-	-	S	-	-	-	AAA domain
PIKALECD_00674	1.1e-165	-	-	-	L	-	-	-	DNA alkylation repair enzyme
PIKALECD_00675	4.85e-296	serS3	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PIKALECD_00676	2.18e-77	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_00677	2.11e-42	-	-	-	K	-	-	-	FR47-like protein
PIKALECD_00678	4.23e-76	ydzF	-	-	K	-	-	-	HxlR-like helix-turn-helix
PIKALECD_00679	4.98e-221	-	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Arginase family
PIKALECD_00680	5.96e-146	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_00681	6.13e-171	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
PIKALECD_00682	3.92e-142	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
PIKALECD_00683	8.4e-150	-	-	-	S	-	-	-	3-demethylubiquinone-9 3-methyltransferase
PIKALECD_00684	4.3e-168	-	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
PIKALECD_00685	7.1e-119	-	-	-	K	-	-	-	Winged helix DNA-binding domain
PIKALECD_00686	3.41e-231	pld1	1.1.1.122	-	C	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Aldo/keto reductase family
PIKALECD_00687	6.5e-46	-	-	-	G	ko:K09973	-	ko00000	PFAM GumN family protein
PIKALECD_00688	2.24e-47	-	-	-	L	ko:K07483	-	ko00000	Transposase
PIKALECD_00689	4.42e-43	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_00690	9.01e-35	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_00691	5.49e-48	-	-	-	L	ko:K07483	-	ko00000	Transposase
PIKALECD_00692	6.89e-259	-	-	-	L	ko:K07487	-	ko00000	Transposase domain (DUF772)
PIKALECD_00693	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
PIKALECD_00694	4.93e-175	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_00695	1.4e-160	rrp1	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_00696	1.09e-229	-	-	-	T	-	-	-	Histidine kinase-like ATPases
PIKALECD_00697	6.28e-36	-	-	-	S	-	-	-	Helix-turn-helix domain
PIKALECD_00698	1.14e-36	-	-	-	S	-	-	-	Domain of unknown function (DUF3173)
PIKALECD_00699	3.89e-284	-	-	-	L	-	-	-	Arm DNA-binding domain
PIKALECD_00700	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
PIKALECD_00701	0.0	yebA	-	-	E	-	-	-	COG1305 Transglutaminase-like enzymes
PIKALECD_00702	2.38e-256	yeaD	-	-	S	-	-	-	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
PIKALECD_00703	2.1e-218	yeaC	-	-	S	ko:K03924	-	ko00000,ko01000	COG0714 MoxR-like ATPases
PIKALECD_00704	4.8e-128	-	-	-	CO	-	-	-	Thioredoxin
PIKALECD_00705	2.81e-232	yvnB	-	-	Q	-	-	-	Calcineurin-like phosphoesterase
PIKALECD_00707	4.04e-13	-	-	-	-	-	-	-	-
PIKALECD_00708	0.0	pbpC	3.4.16.4	-	M	ko:K02545,ko:K21467	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	Penicillin-binding Protein
PIKALECD_00709	2.27e-138	yfhC	-	-	C	-	-	-	nitroreductase
PIKALECD_00710	6.48e-152	cwlC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
PIKALECD_00711	7.48e-79	-	-	-	S	-	-	-	Bacteriophage holin family
PIKALECD_00713	0.0	-	-	-	L	-	-	-	Phage minor structural protein
PIKALECD_00714	2.04e-167	-	-	-	S	-	-	-	Phage tail protein
PIKALECD_00715	7.17e-184	-	-	-	D	-	-	-	Phage tail tape measure protein, TP901 family
PIKALECD_00716	6.77e-100	-	-	-	-	-	-	-	-
PIKALECD_00717	3.67e-93	-	-	-	-	-	-	-	-
PIKALECD_00718	1.75e-69	-	-	-	S	-	-	-	Short C-terminal domain
PIKALECD_00719	1.95e-270	-	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
PIKALECD_00720	5.21e-310	malP	-	-	C	ko:K11616	ko02020,map02020	ko00000,ko00001	COG3493 Na citrate symporter
PIKALECD_00721	8.29e-161	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
PIKALECD_00722	0.0	malK	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
PIKALECD_00723	2.91e-94	-	-	-	M	-	-	-	ArpU family transcriptional regulator
PIKALECD_00724	6.89e-192	-	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
PIKALECD_00725	1.09e-151	-	-	-	E	ko:K02029,ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00726	7.32e-144	-	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_00727	1.62e-192	tcyA_1	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
PIKALECD_00728	1.44e-173	-	-	-	-	-	-	-	-
PIKALECD_00729	5e-193	-	-	-	S	ko:K07025	-	ko00000	Haloacid dehalogenase-like hydrolase
PIKALECD_00730	2.22e-231	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
PIKALECD_00731	1.2e-89	-	-	-	S	-	-	-	GtrA-like protein
PIKALECD_00732	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
PIKALECD_00733	2.57e-10	-	-	-	-	-	-	-	-
PIKALECD_00734	1.01e-09	-	-	-	-	-	-	-	-
PIKALECD_00735	5.95e-112	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PIKALECD_00736	2.66e-172	fdhD	-	-	C	ko:K02379	-	ko00000	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PIKALECD_00737	5.65e-136	yjgD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
PIKALECD_00738	0.0	yjgC	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase (NAD+) activity
PIKALECD_00739	6.95e-180	nirC	-	-	P	ko:K02598	-	ko00000,ko02000	Formate/nitrite transporter
PIKALECD_00740	3.38e-46	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PIKALECD_00741	3.97e-97	moaE	2.8.1.12	-	H	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	COG0314 Molybdopterin converting factor, large subunit
PIKALECD_00742	9.52e-115	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
PIKALECD_00743	5.49e-299	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	molybdopterin
PIKALECD_00744	1.34e-233	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PIKALECD_00745	3.23e-108	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
PIKALECD_00746	6.47e-124	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
PIKALECD_00747	7.31e-114	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
PIKALECD_00748	0.0	yoaI	1.14.14.9	-	Q	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	ko00000,ko00001,ko01000	COG2368 Aromatic ring hydroxylase
PIKALECD_00749	2.89e-181	-	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
PIKALECD_00750	3.39e-156	ypdP	-	-	S	ko:K09125	-	ko00000	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PIKALECD_00751	4.77e-165	-	-	-	S	-	-	-	carbohydrate derivative metabolic process
PIKALECD_00752	1.25e-282	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
PIKALECD_00753	5.5e-56	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
PIKALECD_00754	1.37e-94	-	2.7.1.194	-	GT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_00755	0.0	-	-	-	G	-	-	-	Mga helix-turn-helix domain
PIKALECD_00756	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
PIKALECD_00757	7.46e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PIKALECD_00758	7.8e-152	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
PIKALECD_00759	8.02e-255	gldA	-	-	C	ko:K08317	-	ko00000,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
PIKALECD_00760	2.91e-190	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1464 ABC-type metal ion transport system, periplasmic component surface antigen
PIKALECD_00761	1.31e-141	metP_2	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
PIKALECD_00762	3.41e-233	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PIKALECD_00763	1.16e-178	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PIKALECD_00764	7.3e-34	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
PIKALECD_00765	3.56e-145	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PIKALECD_00766	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
PIKALECD_00767	1.13e-228	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PIKALECD_00768	1.23e-111	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
PIKALECD_00769	6.56e-164	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214 Inactive homolog of metal-dependent proteases
PIKALECD_00770	4.32e-105	ydiB	-	-	S	ko:K06925	-	ko00000,ko03016	ATPase or kinase
PIKALECD_00771	6.6e-230	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PIKALECD_00774	8.25e-271	-	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
PIKALECD_00775	7.27e-73	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PIKALECD_00776	6.37e-78	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PIKALECD_00777	8.89e-156	sapB	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
PIKALECD_00778	6.12e-235	-	-	-	V	-	-	-	Domain of unknown function (DUF3471)
PIKALECD_00779	1.29e-85	puuR	-	-	K	-	-	-	sequence-specific DNA binding
PIKALECD_00780	4.24e-89	puuR	-	-	K	-	-	-	sequence-specific DNA binding
PIKALECD_00782	2.91e-259	dhaT	1.1.1.202	-	C	ko:K00086	ko00561,ko00640,map00561,map00640	ko00000,ko00001,ko01000	alcohol dehydrogenase
PIKALECD_00783	3.81e-17	-	-	-	-	-	-	-	-
PIKALECD_00784	0.0	cckA	2.7.13.3	-	T	ko:K02482	-	ko00000,ko01000,ko01001,ko02022	GAF domain
PIKALECD_00785	0.0	-	-	-	T	ko:K02481	-	ko00000,ko02022	Sigma-54 interaction domain
PIKALECD_00786	2.39e-253	adhA	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
PIKALECD_00787	0.0	dhaS	1.2.1.3, 1.2.1.39	-	C	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
PIKALECD_00788	1.33e-225	-	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
PIKALECD_00790	0.0	yaaO	-	-	E	-	-	-	Orn Lys Arg decarboxylase
PIKALECD_00791	6.14e-147	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PIKALECD_00792	9.77e-71	yaaQ	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00793	3.03e-233	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
PIKALECD_00794	3.66e-188	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
PIKALECD_00795	1.21e-59	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
PIKALECD_00796	1.28e-172	yabB	2.1.1.223	-	S	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Conserved hypothetical protein 95
PIKALECD_00797	9.86e-54	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
PIKALECD_00798	1.29e-199	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PIKALECD_00799	3.04e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	COG2002 Regulators of stationary sporulation gene expression
PIKALECD_00800	1.13e-220	-	-	-	S	-	-	-	NurA
PIKALECD_00801	0.0	-	-	-	S	ko:K06915	-	ko00000	Domain of unknown function DUF87
PIKALECD_00802	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PIKALECD_00803	1.34e-101	-	-	-	K	-	-	-	DNA-binding transcription factor activity
PIKALECD_00804	5.54e-236	pelB	4.2.2.2	-	G	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Amb_all
PIKALECD_00806	0.0	-	-	-	S	-	-	-	ABC transporter
PIKALECD_00807	1.68e-146	-	-	-	T	-	-	-	protein histidine kinase activity
PIKALECD_00808	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3298)
PIKALECD_00809	2.49e-182	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD
PIKALECD_00810	7.33e-267	yabE	-	-	T	-	-	-	protein conserved in bacteria
PIKALECD_00811	5.18e-130	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PIKALECD_00812	2.4e-201	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
PIKALECD_00813	2.53e-208	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
PIKALECD_00814	4.02e-53	veg	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00815	1.8e-34	sspF	-	-	S	ko:K06423	-	ko00000	DNA topological change
PIKALECD_00816	1.3e-208	ispE	2.7.1.148	-	I	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PIKALECD_00817	1.56e-190	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
PIKALECD_00818	1.36e-79	yabJ	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	translation initiation inhibitor, yjgF family
PIKALECD_00819	2.26e-64	spoVG	-	-	D	ko:K06412	-	ko00000	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
PIKALECD_00820	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PIKALECD_00821	7.02e-218	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PIKALECD_00822	1.21e-135	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PIKALECD_00823	2.48e-130	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
PIKALECD_00824	7.09e-51	yabK	-	-	S	-	-	-	Peptide ABC transporter permease
PIKALECD_00825	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PIKALECD_00826	6.61e-123	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein
PIKALECD_00827	8.77e-132	-	-	-	S	-	-	-	Yip1 domain
PIKALECD_00828	1.43e-252	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PIKALECD_00829	8.06e-115	-	-	-	S	-	-	-	Yip1 domain
PIKALECD_00830	0.0	yabM	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PIKALECD_00831	0.0	yabN	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
PIKALECD_00832	1.89e-43	yabO	-	-	J	-	-	-	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
PIKALECD_00833	1.89e-149	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
PIKALECD_00834	1.67e-223	yvcT	1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81	-	CH	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PIKALECD_00835	5.14e-111	-	2.3.1.128	-	K	ko:K03790	-	ko00000,ko01000,ko03009	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_00836	7.94e-241	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
PIKALECD_00837	7.16e-128	-	-	-	S	-	-	-	SNARE associated Golgi protein
PIKALECD_00838	3.77e-68	yabP	-	-	S	-	-	-	Sporulation protein YabP
PIKALECD_00839	1.8e-92	yabQ	-	-	S	-	-	-	spore cortex biosynthesis protein
PIKALECD_00840	2.87e-79	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
PIKALECD_00841	8.65e-92	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
PIKALECD_00843	3.42e-283	citM	-	-	C	ko:K03300	-	ko00000	Citrate transporter
PIKALECD_00844	0.0	spoIIE	3.1.3.16	-	KT	ko:K06382	-	ko00000,ko01000	stage II sporulation protein E
PIKALECD_00845	2.67e-166	yabS	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
PIKALECD_00846	6.67e-223	yabT	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	serine threonine protein kinase
PIKALECD_00847	0.0	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
PIKALECD_00848	9.01e-121	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
PIKALECD_00849	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PIKALECD_00850	1.5e-182	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PIKALECD_00851	6.63e-201	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PIKALECD_00852	2.28e-221	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
PIKALECD_00853	0.0	pabB	2.6.1.85	-	EH	ko:K01665	ko00790,map00790	ko00000,ko00001,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PIKALECD_00854	7.58e-140	pabA	2.6.1.85	-	EH	ko:K01664	ko00790,map00790	ko00000,ko00001,ko01000	Anthranilate synthase
PIKALECD_00855	3.14e-191	pabC	4.1.3.38	-	EH	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	4-amino-4-deoxychorismate lyase
PIKALECD_00856	2.91e-189	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PIKALECD_00857	1.81e-81	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PIKALECD_00858	5.29e-121	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PIKALECD_00859	4.37e-241	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PIKALECD_00860	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
PIKALECD_00861	6.8e-224	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
PIKALECD_00862	1.15e-206	lplC7	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
PIKALECD_00863	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_00864	0.0	-	3.2.1.80	-	G	ko:K03332	ko00051,map00051	ko00000,ko00001,ko01000	invertase
PIKALECD_00865	0.0	cscA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
PIKALECD_00866	9.13e-161	fabG9	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
PIKALECD_00867	2.14e-281	yaaH	-	-	M	ko:K06306	-	ko00000	Glycoside Hydrolase Family
PIKALECD_00868	3.18e-37	-	-	-	-	-	-	-	-
PIKALECD_00869	1.89e-123	pncA	-	-	Q	-	-	-	COG1335 Amidases related to nicotinamidase
PIKALECD_00870	6.94e-146	ymaB	-	-	S	-	-	-	MutT family
PIKALECD_00871	3.1e-246	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PIKALECD_00872	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PIKALECD_00873	4.03e-83	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
PIKALECD_00874	2.63e-165	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
PIKALECD_00875	1.27e-249	-	-	-	M	-	-	-	Glycosyltransferase like family 2
PIKALECD_00876	0.0	tuaA	-	-	M	-	-	-	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
PIKALECD_00877	3.35e-292	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PIKALECD_00878	7.68e-173	-	-	-	I	-	-	-	CDP-alcohol phosphatidyltransferase
PIKALECD_00879	7.06e-93	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase
PIKALECD_00880	0.0	-	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
PIKALECD_00881	0.0	-	-	-	M	-	-	-	Glycosyltransferase like family 2
PIKALECD_00882	1.4e-206	-	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
PIKALECD_00883	0.0	-	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
PIKALECD_00884	7.86e-245	ywtF_2	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_00885	5.98e-105	-	-	-	K	ko:K03718	-	ko00000,ko03000	helix_turn_helix ASNC type
PIKALECD_00886	1.47e-244	oppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_00887	2.59e-190	oppF	-	-	P	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_00888	4.99e-225	oppB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_00889	8.72e-203	oppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	binding-protein-dependent transport systems inner membrane component
PIKALECD_00890	0.0	oppA1	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_00891	5.28e-132	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PIKALECD_00892	1.29e-147	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
PIKALECD_00893	7.16e-257	degS	2.7.13.3	-	T	ko:K07683,ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
PIKALECD_00894	4.63e-162	degU	-	-	KT	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PIKALECD_00895	3.68e-191	degV	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_00896	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PIKALECD_00897	5e-161	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Phosphoribosyl transferase domain
PIKALECD_00898	4.48e-98	yvyF	-	-	S	-	-	-	flagellar protein
PIKALECD_00899	3.56e-52	-	-	-	N	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	ko00000,ko00001,ko02035	Anti-sigma-28 factor, FlgM
PIKALECD_00900	2.18e-07	yvyG	-	-	NOU	-	-	-	Flagellar biosynthesis protein FlgN
PIKALECD_00901	0.0	flgK	-	-	N	ko:K02396	ko02040,map02040	ko00000,ko00001,ko02035	flagellar hook-associated protein
PIKALECD_00902	3.43e-239	flgL	-	-	N	ko:K02397	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the bacterial flagellin family
PIKALECD_00903	7.62e-97	fliW	-	-	S	ko:K13626	-	ko00000,ko02035	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PIKALECD_00904	2.29e-44	csrA	-	-	T	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	ko00000,ko00001,ko03019	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PIKALECD_00905	1.25e-63	flaG	-	-	N	ko:K06603	-	ko00000,ko02035	flagellar protein FlaG
PIKALECD_00906	0.0	fliD	-	-	N	ko:K02407	ko02040,map02040	ko00000,ko00001,ko02035	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PIKALECD_00907	3.64e-86	fliS	-	-	N	ko:K02422	ko02040,map02040	ko00000,ko00001,ko02035	flagellar protein FliS
PIKALECD_00909	3.79e-189	-	-	-	-	-	-	-	-
PIKALECD_00910	4.78e-42	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	cold-shock protein
PIKALECD_00911	6.07e-126	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PIKALECD_00912	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
PIKALECD_00913	1.02e-232	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PIKALECD_00914	5.34e-188	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
PIKALECD_00915	2.48e-159	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
PIKALECD_00916	1.27e-193	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
PIKALECD_00917	4.45e-162	-	-	-	D	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	peptidase
PIKALECD_00918	0.0	ctpB	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
PIKALECD_00919	3.27e-258	minJ	-	-	O	-	-	-	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PIKALECD_00920	3.73e-216	yoaV3	-	-	EG	-	-	-	EamA-like transporter family
PIKALECD_00921	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
PIKALECD_00922	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
PIKALECD_00923	1.29e-200	yvlB	-	-	S	-	-	-	Putative adhesin
PIKALECD_00924	7.33e-16	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain protein
PIKALECD_00925	2.08e-63	yvlD	-	-	S	ko:K08972	-	ko00000	Membrane
PIKALECD_00926	2.18e-218	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PIKALECD_00927	8.3e-190	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PIKALECD_00928	3.94e-204	yvoD	-	-	P	-	-	-	COG0370 Fe2 transport system protein B
PIKALECD_00929	2.32e-151	ppaX	3.6.1.1	-	S	ko:K06019	ko00190,map00190	ko00000,ko00001,ko01000	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
PIKALECD_00930	1.43e-105	yvoF	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
PIKALECD_00931	2.04e-19	-	-	-	-	-	-	-	-
PIKALECD_00932	4.79e-95	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
PIKALECD_00933	1.2e-121	mcsA	-	-	S	ko:K19411	-	ko00000	protein with conserved CXXC pairs
PIKALECD_00934	1.88e-250	mcsB	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
PIKALECD_00935	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
PIKALECD_00936	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PIKALECD_00937	1.17e-248	disA	2.7.7.85	-	L	ko:K07067	-	ko00000,ko01000	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PIKALECD_00938	1.38e-252	yacL	-	-	S	-	-	-	COG4956 Integral membrane protein (PIN domain superfamily)
PIKALECD_00939	1.13e-150	ispD	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
PIKALECD_00940	1.49e-107	ispF	2.7.7.60, 4.6.1.12	-	I	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
PIKALECD_00941	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PIKALECD_00942	1.63e-155	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
PIKALECD_00943	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
PIKALECD_00944	8.52e-91	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PIKALECD_00945	3.82e-184	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PIKALECD_00946	5.28e-111	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
PIKALECD_00947	9.77e-152	comX	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
PIKALECD_00948	2.37e-34	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
PIKALECD_00949	1.83e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
PIKALECD_00950	1.19e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PIKALECD_00951	4.64e-160	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
PIKALECD_00952	8.48e-106	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PIKALECD_00953	1.27e-69	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
PIKALECD_00954	2.91e-148	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
PIKALECD_00955	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PIKALECD_00956	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PIKALECD_00957	3.72e-47	rplGB	-	-	J	ko:K07590	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the eukaryotic ribosomal protein eL8 family
PIKALECD_00958	4.33e-95	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PIKALECD_00959	1.19e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
PIKALECD_00960	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PIKALECD_00961	6.72e-286	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PIKALECD_00962	2.58e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
PIKALECD_00963	9.49e-143	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PIKALECD_00964	2.22e-137	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
PIKALECD_00965	1.38e-59	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
PIKALECD_00966	5.09e-200	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PIKALECD_00967	1.53e-61	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PIKALECD_00968	8.5e-72	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PIKALECD_00969	1.76e-154	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PIKALECD_00970	3.79e-101	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PIKALECD_00971	5.12e-38	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
PIKALECD_00972	2.17e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PIKALECD_00973	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PIKALECD_00974	7.7e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PIKALECD_00975	2.21e-121	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PIKALECD_00976	1.54e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PIKALECD_00977	1.83e-124	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PIKALECD_00978	8.96e-79	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PIKALECD_00979	1.59e-110	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PIKALECD_00980	7.06e-36	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
PIKALECD_00981	9.26e-98	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
PIKALECD_00982	1.39e-296	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
PIKALECD_00983	7.76e-152	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
PIKALECD_00984	1.1e-180	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
PIKALECD_00985	4.15e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PIKALECD_00986	5.99e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
PIKALECD_00987	8.92e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PIKALECD_00988	4.05e-85	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PIKALECD_00989	4.06e-216	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PIKALECD_00990	1.49e-77	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
PIKALECD_00991	1.57e-201	cbiO	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PIKALECD_00992	3.48e-185	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PIKALECD_00993	1.77e-169	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PIKALECD_00994	6.89e-186	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
PIKALECD_00995	2.77e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PIKALECD_00996	4.45e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
PIKALECD_00997	1.54e-106	-	-	-	S	-	-	-	Protein of unknown function (DUF2975)
PIKALECD_00998	1.26e-40	yozG	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_00999	6.11e-90	ykkB	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
PIKALECD_01000	4.26e-104	ybaK	-	-	S	-	-	-	Protein of unknown function (DUF2521)
PIKALECD_01001	1.75e-170	cwlD	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
PIKALECD_01002	2.12e-189	glcT	-	-	K	ko:K03480,ko:K03488	-	ko00000,ko03000	antiterminator
PIKALECD_01003	0.0	ptsG	2.7.1.199	-	G	ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_01004	2.18e-245	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
PIKALECD_01005	2.04e-28	lacF	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_01006	6.63e-96	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PIKALECD_01007	1.67e-40	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PFAM Phosphotransferase system, lactose cellobiose-specific IIB subunit
PIKALECD_01008	2.87e-221	-	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PIKALECD_01009	3.36e-92	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
PIKALECD_01010	1.29e-214	-	-	-	S	-	-	-	Protein of unknown function (DUF4127)
PIKALECD_01011	7.85e-120	-	-	-	K	-	-	-	transcriptional regulator, RpiR family
PIKALECD_01012	6.68e-96	gerD	-	-	S	ko:K06294	-	ko00000	Spore gernimation protein
PIKALECD_01013	8e-130	kbaA	-	-	S	ko:K06349	-	ko00000	Involved in the activation of the KinB signaling pathway of sporulation
PIKALECD_01014	8.38e-183	pdaB	-	-	G	-	-	-	Polysaccharide deacetylase
PIKALECD_01015	5.74e-46	-	-	-	-	-	-	-	-
PIKALECD_01016	1.95e-201	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
PIKALECD_01017	1.98e-193	dkgB	-	-	S	-	-	-	Aldo/keto reductase family
PIKALECD_01018	9.15e-216	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_01019	4.65e-184	-	-	-	K	-	-	-	Helix-turn-helix domain
PIKALECD_01020	2.78e-73	-	-	-	S	-	-	-	Ketosteroid isomerase-related protein
PIKALECD_01021	5.68e-235	-	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
PIKALECD_01022	2.4e-230	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_01023	9.41e-278	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_01024	6.21e-214	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_01025	8.85e-181	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_01026	7.29e-245	-	-	-	G	-	-	-	Xylose isomerase
PIKALECD_01027	2.27e-198	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
PIKALECD_01029	3.09e-141	-	-	-	K	ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
PIKALECD_01030	3.04e-80	-	-	-	-	-	-	-	-
PIKALECD_01031	1.23e-32	-	-	-	-	-	-	-	-
PIKALECD_01032	1.52e-114	-	1.8.5.2	-	S	ko:K16937	ko00920,ko01120,map00920,map01120	ko00000,ko00001,ko01000	DoxX
PIKALECD_01033	0.0	-	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PIKALECD_01034	3.54e-193	yojH	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
PIKALECD_01035	2.16e-130	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_01036	1.41e-144	yqeB	-	-	-	-	-	-	-
PIKALECD_01037	7.19e-58	-	-	-	K	ko:K10947	-	ko00000,ko03000	PadR family transcriptional regulator
PIKALECD_01038	2.4e-118	-	-	-	V	-	-	-	(ABC) transporter
PIKALECD_01039	5.11e-209	-	-	-	V	-	-	-	VanW like protein
PIKALECD_01042	1.25e-150	yoqW	-	-	S	-	-	-	Belongs to the SOS response-associated peptidase family
PIKALECD_01043	7.09e-225	isp	-	-	O	ko:K13275	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
PIKALECD_01044	1.79e-206	yjlA	-	-	EG	-	-	-	Putative multidrug resistance efflux transporter
PIKALECD_01045	0.0	-	-	-	-	-	-	-	-
PIKALECD_01046	8.44e-248	dctP	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PIKALECD_01047	0.0	-	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase
PIKALECD_01048	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
PIKALECD_01049	1.15e-108	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
PIKALECD_01050	2.17e-62	-	-	-	-	-	-	-	-
PIKALECD_01051	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
PIKALECD_01052	3.02e-06	sda	-	-	S	ko:K06371	-	ko00000	sporulation
PIKALECD_01054	1.1e-86	yqiX	-	-	S	-	-	-	YolD-like protein
PIKALECD_01055	2.73e-283	-	-	-	P	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
PIKALECD_01056	2.98e-288	-	-	-	GK	-	-	-	ROK family
PIKALECD_01057	4.41e-309	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_01058	1.48e-218	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_01059	1.57e-189	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_01060	7.86e-242	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_01061	7.51e-238	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_01062	2.73e-201	-	5.1.3.22	-	G	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Xylose isomerase-like TIM barrel
PIKALECD_01063	6.83e-223	-	3.8.1.3	-	S	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Alpha/beta hydrolase family
PIKALECD_01064	3.39e-191	gltR3	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_01065	7.99e-158	yxjF	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
PIKALECD_01066	4.41e-275	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
PIKALECD_01067	0.0	-	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	the major facilitator superfamily
PIKALECD_01068	1.52e-144	-	-	-	K	-	-	-	Bacterial transcriptional repressor C-terminal
PIKALECD_01069	1.29e-190	-	-	-	S	-	-	-	Methyltransferase domain
PIKALECD_01070	8.77e-286	adhB	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
PIKALECD_01071	2.98e-219	fhuD11	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
PIKALECD_01072	1.16e-221	fhuG7	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_01073	2.94e-71	isdG	1.14.99.48	-	C	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron
PIKALECD_01074	1.96e-156	isdC	-	-	M	-	-	-	NEAr Transporter domain
PIKALECD_01075	0.0	-	-	-	M	-	-	-	Cell surface protein
PIKALECD_01076	2.33e-209	isdE	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_01077	6.69e-217	fhuB11	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_01078	1.27e-174	fepC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
PIKALECD_01079	5.66e-182	srtB	3.4.22.70	-	S	ko:K08600	-	ko00000,ko01000,ko01002,ko01011	Sortase family
PIKALECD_01080	2.75e-306	-	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
PIKALECD_01081	1.34e-51	ymfJ	-	-	S	-	-	-	Protein of unknown function (DUF3243)
PIKALECD_01082	2.17e-152	ymfI	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_01083	2.38e-310	ymfH	-	-	S	-	-	-	zinc protease
PIKALECD_01084	4.96e-289	albE	-	-	S	-	-	-	Peptidase M16
PIKALECD_01085	1.18e-165	ymfC	-	-	K	ko:K03710	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_01086	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
PIKALECD_01087	1.37e-06	-	-	-	S	-	-	-	YlzJ-like protein
PIKALECD_01088	3.79e-165	tepA	-	-	OU	-	-	-	COG0740 Protease subunit of ATP-dependent Clp proteases
PIKALECD_01089	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PIKALECD_01090	1.24e-201	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PIKALECD_01091	2.52e-281	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
PIKALECD_01092	2.96e-243	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PIKALECD_01093	7.62e-138	spoVFB	-	-	H	ko:K06411	-	ko00000	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
PIKALECD_01094	3.86e-204	spoVFA	-	-	E	ko:K06410	-	ko00000	subunit a
PIKALECD_01095	1.52e-48	ymxH	-	-	S	-	-	-	YlmC YmxH family
PIKALECD_01096	1.39e-278	mlpA	-	-	S	-	-	-	Belongs to the peptidase M16 family
PIKALECD_01097	1.78e-240	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
PIKALECD_01098	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
PIKALECD_01099	7.11e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PIKALECD_01100	1.95e-222	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
PIKALECD_01101	2.88e-219	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PIKALECD_01102	2.49e-75	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PIKALECD_01103	2.96e-55	ylxP	-	-	S	ko:K09764	-	ko00000	protein conserved in bacteria
PIKALECD_01104	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PIKALECD_01105	3.53e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
PIKALECD_01106	1.66e-56	ylxR	-	-	K	ko:K07742	-	ko00000	nucleic-acid-binding protein implicated in transcription termination
PIKALECD_01107	3.99e-257	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
PIKALECD_01108	3.83e-104	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
PIKALECD_01109	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PIKALECD_01110	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
PIKALECD_01111	7.23e-283	rasP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
PIKALECD_01112	7.52e-263	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
PIKALECD_01113	3.35e-175	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
PIKALECD_01114	6.15e-187	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PIKALECD_01115	3.08e-115	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
PIKALECD_01116	3.37e-160	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
PIKALECD_01117	2.05e-199	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PIKALECD_01118	1.89e-169	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
PIKALECD_01119	1.99e-05	ylxL	-	-	-	-	-	-	-
PIKALECD_01120	1e-170	sigD	-	-	K	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_01121	4.45e-109	cheD	3.5.1.44	-	NT	ko:K03411	ko02030,map02030	ko00000,ko00001,ko01000,ko02035	Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
PIKALECD_01122	1.02e-136	cheC	-	-	NT	ko:K03410	ko02030,map02030	ko00000,ko00001,ko02035	COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
PIKALECD_01123	9.45e-208	cheB	3.1.1.61, 3.5.1.44	-	NT	ko:K03412	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
PIKALECD_01124	2.84e-123	-	-	-	-	-	-	-	-
PIKALECD_01125	1.37e-222	flhF	-	-	N	ko:K02404	-	ko00000,ko02035	Flagellar biosynthesis regulator FlhF
PIKALECD_01126	0.0	flhA	-	-	N	ko:K02400	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PIKALECD_01127	2.3e-237	flhB	-	-	N	ko:K02401	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PIKALECD_01128	2.52e-167	fliR	-	-	N	ko:K02421	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthetic protein FliR
PIKALECD_01129	8.01e-54	fliQ	-	-	N	ko:K02420	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Role in flagellar biosynthesis
PIKALECD_01130	5.99e-145	fliP	-	-	N	ko:K02419	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Plays a role in the flagellum-specific transport system
PIKALECD_01131	4.36e-133	fliZ	-	-	N	ko:K02418	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthesis protein, FliO
PIKALECD_01132	1.05e-77	cheY	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
PIKALECD_01133	3.16e-261	fliY	-	-	N	ko:K02417	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035,ko02044	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PIKALECD_01134	7.63e-224	fliM	-	-	N	ko:K02416	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
PIKALECD_01135	9.32e-92	fliL	-	-	N	ko:K02415	-	ko00000,ko02035	Controls the rotational direction of flagella during chemotaxis
PIKALECD_01136	1.26e-37	flbD	-	-	N	ko:K02385	-	ko00000,ko02035	protein, possibly involved in motility
PIKALECD_01137	2.96e-174	flgG	-	-	N	ko:K02390	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod
PIKALECD_01138	1.05e-93	flgD	-	-	N	ko:K02389	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod modification protein
PIKALECD_01139	1.95e-259	-	-	-	N	ko:K02414	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-length control protein FliK
PIKALECD_01141	5.98e-90	fliJ	-	-	N	ko:K02413	ko02040,map02040	ko00000,ko00001,ko02035	bacterial-type flagellum organization
PIKALECD_01142	3.41e-312	fliI	3.6.3.14	-	NU	ko:K02412	ko02040,map02040	ko00000,ko00001,ko01000,ko02035,ko02044	COG1157 Flagellar biosynthesis type III secretory pathway ATPase
PIKALECD_01143	9.58e-103	fliH	-	-	NU	ko:K02411	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	COG1317 Flagellar biosynthesis type III secretory pathway protein
PIKALECD_01144	1.32e-227	fliG	-	-	N	ko:K02410	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
PIKALECD_01145	0.0	fliF	-	-	N	ko:K02409	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	The M ring may be actively involved in energy transduction
PIKALECD_01146	3.76e-54	fliE	-	-	N	ko:K02408	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-basal body
PIKALECD_01147	2.97e-95	flgC	-	-	N	ko:K02388	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the flagella basal body rod proteins family
PIKALECD_01148	1.18e-86	flgB	-	-	N	ko:K02387	ko02040,map02040	ko00000,ko00001,ko02035	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
PIKALECD_01149	2.27e-174	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PIKALECD_01150	1.13e-295	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PIKALECD_01151	2.12e-120	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PIKALECD_01152	1.31e-214	xerC	-	-	L	ko:K03733,ko:K04763	-	ko00000,ko03036	tyrosine recombinase XerC
PIKALECD_01153	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PIKALECD_01154	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PIKALECD_01155	1.75e-215	dprA	-	-	LU	ko:K04096	-	ko00000	Rossmann fold nucleotide-binding protein involved in DNA uptake
PIKALECD_01156	3.09e-215	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PIKALECD_01157	1.27e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
PIKALECD_01158	9.95e-98	ylqH	-	-	S	ko:K04061	-	ko00000,ko02044	FlhB HrpN YscU SpaS Family
PIKALECD_01160	1.54e-174	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PIKALECD_01162	1.34e-199	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PIKALECD_01163	2.39e-132	sipS	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
PIKALECD_01164	1.9e-11	-	-	-	-	-	-	-	-
PIKALECD_01165	5.47e-110	MA20_20600	1.14.17.3	-	CO	ko:K00504	-	ko00000,ko01000	amine dehydrogenase activity
PIKALECD_01166	4.61e-147	-	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	amidotransferase, A subunit
PIKALECD_01168	1.86e-93	-	4.1.2.52	-	G	ko:K02510	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
PIKALECD_01170	2.95e-262	aldHT_2	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Aldehyde dehydrogenase family
PIKALECD_01171	3.42e-227	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_01172	1.03e-66	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_01173	3.3e-148	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_01174	1.62e-195	-	-	-	E	-	-	-	aminopeptidase
PIKALECD_01175	6.63e-76	-	-	-	J	-	-	-	YjgF/chorismate_mutase-like, putative endoribonuclease
PIKALECD_01176	6.89e-154	ycbC	4.2.1.41	-	EM	ko:K01707	ko00053,ko01100,map00053,map01100	ko00000,ko00001,ko01000	Dihydrodipicolinate synthetase family
PIKALECD_01177	1.76e-09	-	-	-	L	ko:K07491	-	ko00000	Transposase
PIKALECD_01178	0.0	-	-	-	L	-	-	-	COG3666 Transposase and inactivated derivatives
PIKALECD_01179	1.35e-73	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
PIKALECD_01180	0.0	-	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl tRNA synthetase N terminal dom
PIKALECD_01181	2.12e-167	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
PIKALECD_01182	8.9e-122	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PIKALECD_01183	2.5e-90	-	-	-	S	-	-	-	YlqD protein
PIKALECD_01184	1.11e-45	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
PIKALECD_01185	7.93e-59	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
PIKALECD_01186	2.4e-312	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PIKALECD_01187	5.45e-68	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PIKALECD_01188	3.38e-226	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
PIKALECD_01189	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
PIKALECD_01190	1.67e-14	yfkK	-	-	S	-	-	-	Belongs to the UPF0435 family
PIKALECD_01191	1.55e-177	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
PIKALECD_01192	1.35e-42	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PIKALECD_01193	1.16e-161	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
PIKALECD_01194	3.45e-214	fabD	2.3.1.39	-	I	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	malonyl CoA-acyl carrier protein transacylase
PIKALECD_01195	2.9e-228	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
PIKALECD_01196	1.53e-127	fapR	-	-	K	-	-	-	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
PIKALECD_01197	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PIKALECD_01198	1.55e-195	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
PIKALECD_01199	1.51e-155	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
PIKALECD_01200	2.67e-191	yitS	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01201	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
PIKALECD_01202	1.81e-78	yloU	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01203	4.09e-35	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
PIKALECD_01204	2.6e-149	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
PIKALECD_01205	2.01e-210	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
PIKALECD_01206	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
PIKALECD_01207	5.6e-170	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
PIKALECD_01208	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PIKALECD_01209	2.04e-224	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PIKALECD_01210	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PIKALECD_01211	1.89e-274	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PIKALECD_01212	2.67e-39	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
PIKALECD_01213	9.15e-143	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
PIKALECD_01214	1.15e-52	ylzA	-	-	S	ko:K09777	-	ko00000	Belongs to the UPF0296 family
PIKALECD_01215	0.0	yloB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
PIKALECD_01216	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
PIKALECD_01217	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
PIKALECD_01219	1.54e-145	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
PIKALECD_01220	1.64e-138	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PIKALECD_01221	2.36e-157	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
PIKALECD_01222	2.73e-211	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
PIKALECD_01223	4.28e-179	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
PIKALECD_01224	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarB family
PIKALECD_01225	2.25e-264	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
PIKALECD_01226	1.73e-306	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
PIKALECD_01227	9.84e-206	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
PIKALECD_01228	5.35e-288	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Xanthine uracil
PIKALECD_01229	3.21e-124	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PIKALECD_01230	2.76e-217	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
PIKALECD_01231	3.71e-95	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PIKALECD_01232	8.84e-112	yteA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
PIKALECD_01233	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PIKALECD_01234	1.53e-95	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
PIKALECD_01235	3.38e-173	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
PIKALECD_01236	7.03e-58	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	membrane
PIKALECD_01237	1.13e-91	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
PIKALECD_01238	2.77e-151	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PIKALECD_01239	2.85e-184	ylmD	-	-	S	ko:K05810	-	ko00000,ko01000	Belongs to the multicopper oxidase YfiH RL5 family
PIKALECD_01240	5.13e-61	ylmC	-	-	S	-	-	-	sporulation protein
PIKALECD_01241	1.05e-180	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_01242	8.95e-161	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_01243	8.42e-205	spoIIGA	-	-	M	ko:K06383	-	ko00000,ko01000,ko01002	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
PIKALECD_01244	3.4e-240	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PIKALECD_01245	4.62e-292	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
PIKALECD_01247	4.2e-165	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
PIKALECD_01248	1.47e-246	spoVE	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
PIKALECD_01249	2.77e-306	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PIKALECD_01250	2.84e-217	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PIKALECD_01251	7.44e-312	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
PIKALECD_01252	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PIKALECD_01253	0.0	spoVD	-	-	M	ko:K08384	ko00550,map00550	ko00000,ko00001,ko01011	stage V sporulation protein D
PIKALECD_01255	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
PIKALECD_01256	2.26e-62	ftsL	-	-	D	-	-	-	cell division protein FtsL
PIKALECD_01257	6.01e-218	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
PIKALECD_01258	4.81e-103	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
PIKALECD_01259	0.0	bshC	-	-	S	ko:K22136	-	ko00000	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PIKALECD_01261	3.84e-184	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PIKALECD_01262	5.16e-120	ylbP	-	-	K	-	-	-	n-acetyltransferase
PIKALECD_01263	4.09e-98	ylbO	-	-	S	ko:K06314	-	ko00000,ko03000	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
PIKALECD_01264	7.12e-36	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
PIKALECD_01265	3.32e-119	ylbN	-	-	S	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
PIKALECD_01266	3.06e-282	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
PIKALECD_01267	2.96e-243	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
PIKALECD_01268	1.17e-177	ylbK	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
PIKALECD_01269	1.04e-271	ylbJ	-	-	S	-	-	-	Sporulation integral membrane protein YlbJ
PIKALECD_01270	7.39e-108	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PIKALECD_01271	2.67e-124	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
PIKALECD_01272	4.19e-84	-	-	-	S	-	-	-	Methylthioribose kinase
PIKALECD_01273	4.89e-63	ylbG	-	-	S	-	-	-	UPF0298 protein
PIKALECD_01274	6.75e-91	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
PIKALECD_01275	2.29e-177	-	-	-	HJ	ko:K05844	-	ko00000,ko01000,ko03009	Prokaryotic glutathione synthetase, ATP-grasp domain
PIKALECD_01276	7.5e-43	ylbE	-	-	S	-	-	-	YlbE-like protein
PIKALECD_01277	1.09e-91	ylbD	-	-	S	-	-	-	Putative coat protein
PIKALECD_01278	2.67e-106	-	-	-	Q	ko:K02614	ko00360,map00360	ko00000,ko00001,ko01000	protein, possibly involved in aromatic compounds catabolism
PIKALECD_01279	9.19e-249	ylbC	-	-	S	-	-	-	protein with SCP PR1 domains
PIKALECD_01280	7.74e-83	ylbA	-	-	S	-	-	-	YugN-like family
PIKALECD_01281	7.94e-109	-	-	-	-	-	-	-	-
PIKALECD_01282	1.87e-119	yozB	-	-	S	ko:K08976	-	ko00000	membrane
PIKALECD_01283	2.95e-68	ctaF	1.9.3.1	-	C	ko:K02277	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
PIKALECD_01284	7.21e-143	ctaE	1.9.3.1	-	C	ko:K02276	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
PIKALECD_01285	0.0	ctaD	1.9.3.1	-	C	ko:K02274	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PIKALECD_01286	2.38e-253	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
PIKALECD_01287	3.05e-203	ctaA	-	-	O	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	ko00000,ko00001,ko00002,ko03029	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
PIKALECD_01288	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PIKALECD_01289	3.87e-56	ylaN	-	-	S	-	-	-	Belongs to the UPF0358 family
PIKALECD_01290	4.9e-116	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PIKALECD_01291	0.0	ylaK	-	-	T	ko:K07175	-	ko00000	ATPase related to phosphate starvation-inducible protein PhoH
PIKALECD_01292	1.07e-43	ylaI	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01293	1.74e-67	ylaH	-	-	S	-	-	-	YlaH-like protein
PIKALECD_01294	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
PIKALECD_01295	1.13e-17	-	-	-	S	-	-	-	Family of unknown function (DUF5325)
PIKALECD_01296	1.52e-208	-	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
PIKALECD_01297	1.2e-194	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase
PIKALECD_01298	1.29e-147	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
PIKALECD_01299	2.47e-52	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
PIKALECD_01300	0.0	speA	4.1.1.17, 4.1.1.19	-	E	ko:K01581,ko:K01585	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Arginine
PIKALECD_01301	6.55e-270	-	-	-	O	-	-	-	Peptidase family M48
PIKALECD_01302	1.95e-167	pdaA_2	3.5.1.104	-	G	ko:K01567,ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
PIKALECD_01303	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
PIKALECD_01304	1.1e-85	-	-	-	CO	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	cell redox homeostasis
PIKALECD_01305	1.7e-207	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_01306	7.93e-222	-	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_01307	0.0	appA_2	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_01308	2.15e-235	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_01309	2.41e-236	appD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_01310	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
PIKALECD_01311	6.67e-248	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PIKALECD_01312	2.48e-227	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PIKALECD_01313	7.59e-256	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PIKALECD_01314	1.46e-131	ykyA	-	-	L	-	-	-	Putative cell-wall binding lipoprotein
PIKALECD_01316	4.29e-130	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
PIKALECD_01317	1.81e-41	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
PIKALECD_01318	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PIKALECD_01319	2.58e-147	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
PIKALECD_01320	7.23e-107	ykuV	-	-	CO	-	-	-	thiol-disulfide
PIKALECD_01321	3.15e-131	ykuU	-	-	O	-	-	-	Alkyl hydroperoxide reductase
PIKALECD_01322	1.1e-161	ykuT	-	-	M	ko:K22044	-	ko00000,ko02000	Mechanosensitive ion channel
PIKALECD_01323	1.46e-50	ykuS	-	-	S	-	-	-	Belongs to the UPF0180 family
PIKALECD_01324	1.17e-268	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
PIKALECD_01325	5.27e-280	-	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
PIKALECD_01326	2.28e-114	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
PIKALECD_01327	5.05e-186	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
PIKALECD_01328	2.4e-234	-	-	-	T	-	-	-	Metal dependent phosphohydrolases with conserved 'HD' motif.
PIKALECD_01329	3.35e-248	yhdY	-	-	M	ko:K16052	-	ko00000,ko02000	Mechanosensitive ion channel
PIKALECD_01331	2.21e-116	copC	-	-	S	ko:K07156	-	ko00000,ko02000	CopC domain
PIKALECD_01332	6.39e-227	ytvI	-	-	S	-	-	-	AI-2E family transporter
PIKALECD_01333	4.49e-132	yhfK	-	-	GM	-	-	-	NmrA-like family
PIKALECD_01334	4.23e-271	-	-	-	E	-	-	-	Peptidase family M28
PIKALECD_01335	1.07e-240	-	-	-	C	-	-	-	Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
PIKALECD_01337	3.83e-127	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_01338	1.58e-37	copZ	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	Heavy-metal-associated domain
PIKALECD_01339	6.7e-62	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	transcriptional
PIKALECD_01340	3.94e-41	-	-	-	-	-	-	-	-
PIKALECD_01341	5.05e-186	ykrA	-	-	S	-	-	-	hydrolases of the HAD superfamily
PIKALECD_01343	3.78e-76	-	-	-	-	-	-	-	-
PIKALECD_01344	2.39e-98	yqiW	-	-	S	-	-	-	Belongs to the UPF0403 family
PIKALECD_01345	4e-280	bkdB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PIKALECD_01346	2.22e-231	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PIKALECD_01347	1.99e-237	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PIKALECD_01348	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
PIKALECD_01349	2.94e-262	ldh	1.4.1.9	-	E	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
PIKALECD_01350	0.0	bkdR	-	-	KT	-	-	-	Transcriptional regulator
PIKALECD_01351	5.51e-47	yqzF	-	-	S	-	-	-	Protein of unknown function (DUF2627)
PIKALECD_01352	1.08e-140	-	-	-	M	-	-	-	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PIKALECD_01353	4.46e-183	spo0A	-	-	KT	ko:K07699	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
PIKALECD_01354	6.95e-300	spoIVB	3.4.21.116	-	M	ko:K06399	-	ko00000,ko01000,ko01002	Stage IV sporulation protein B
PIKALECD_01355	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
PIKALECD_01356	2.64e-103	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
PIKALECD_01357	1.01e-187	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
PIKALECD_01358	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PIKALECD_01359	4.28e-197	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
PIKALECD_01360	2.03e-47	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
PIKALECD_01361	2.98e-270	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
PIKALECD_01362	3.22e-85	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PIKALECD_01363	2.43e-86	yqhY	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01364	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
PIKALECD_01365	2.63e-98	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
PIKALECD_01366	8.84e-74	-	-	-	-	-	-	-	-
PIKALECD_01367	1.41e-115	spoIIIAH	-	-	S	ko:K06397	-	ko00000	SpoIIIAH-like protein
PIKALECD_01368	2.88e-144	spoIIIAG	-	-	S	ko:K06396	-	ko00000	stage III sporulation protein AG
PIKALECD_01369	8.97e-118	spoIIIAF	-	-	S	ko:K06395	-	ko00000	Stage III sporulation protein AF (Spore_III_AF)
PIKALECD_01370	1.88e-256	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
PIKALECD_01371	6.3e-54	spoIIIAD	-	-	S	ko:K06393	-	ko00000	Stage III sporulation protein AD
PIKALECD_01372	1.98e-40	spoIIIAC	-	-	S	ko:K06392	-	ko00000	stage III sporulation protein AC
PIKALECD_01373	4.86e-107	spoIIIAB	-	-	S	ko:K06391	-	ko00000	Stage III sporulation protein
PIKALECD_01374	1.03e-211	spoIIIAA	-	-	S	ko:K06390	-	ko00000	stage III sporulation protein AA
PIKALECD_01375	2.71e-48	yqhV	-	-	S	-	-	-	Protein of unknown function (DUF2619)
PIKALECD_01376	7.6e-61	-	-	-	S	-	-	-	YfzA-like protein
PIKALECD_01377	3.26e-124	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PIKALECD_01378	7.96e-127	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PIKALECD_01379	3.62e-247	yqhT	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
PIKALECD_01380	6.03e-114	yqhR	-	-	S	-	-	-	Conserved membrane protein YqhR
PIKALECD_01381	3.77e-74	-	-	-	-	-	-	-	-
PIKALECD_01382	3.17e-208	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
PIKALECD_01383	3.81e-100	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
PIKALECD_01384	1.43e-250	splB	4.1.99.14	-	L	ko:K03716	-	ko00000,ko01000	Spore photoproduct lyase
PIKALECD_01385	1.29e-197	dat	2.6.1.21	-	E	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	ko00000,ko00001,ko01000,ko01007	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
PIKALECD_01386	0.0	uvrD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
PIKALECD_01387	3.56e-196	lipM	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
PIKALECD_01388	1.34e-81	yqhL	-	-	P	-	-	-	COG0607 Rhodanese-related sulfurtransferase
PIKALECD_01389	0.0	gcvPB	1.4.4.2	-	E	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PIKALECD_01390	0.0	gcvPA	1.4.4.2	-	E	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PIKALECD_01391	2.23e-258	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine
PIKALECD_01392	0.0	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
PIKALECD_01393	8.12e-196	yqhG	-	-	S	-	-	-	Bacterial protein YqhG of unknown function
PIKALECD_01395	7.25e-153	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
PIKALECD_01396	2.65e-48	B4168_0554	-	-	S	-	-	-	Protein of unknown function (DUF2626)
PIKALECD_01399	2.01e-102	-	-	-	-	-	-	-	-
PIKALECD_01401	2.5e-89	-	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	general secretion pathway protein
PIKALECD_01402	1.6e-62	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
PIKALECD_01403	3.58e-55	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
PIKALECD_01413	9.37e-233	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
PIKALECD_01414	6.45e-222	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PIKALECD_01415	0.0	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
PIKALECD_01416	1.12e-74	-	-	-	-	-	-	-	-
PIKALECD_01417	1.77e-94	cotX	-	-	S	ko:K06342	-	ko00000	Spore Coat Protein X and V domain
PIKALECD_01418	6.94e-07	-	-	-	-	-	-	-	-
PIKALECD_01420	1.7e-174	-	-	-	-	-	-	-	-
PIKALECD_01421	1.12e-153	-	-	-	-	-	-	-	-
PIKALECD_01422	6.35e-176	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
PIKALECD_01423	1.16e-74	-	-	-	S	-	-	-	Protein of unknown function (DUF1360)
PIKALECD_01424	8.28e-177	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
PIKALECD_01425	7.23e-208	rluD	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
PIKALECD_01426	7.48e-193	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PIKALECD_01427	1.02e-142	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	GTP pyrophosphokinase
PIKALECD_01428	3.08e-81	yjbL	-	-	S	-	-	-	Belongs to the UPF0738 family
PIKALECD_01429	8.19e-121	yjbK	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01430	3.78e-132	yjbJ	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
PIKALECD_01431	1.67e-95	yjbI	-	-	S	ko:K06886	-	ko00000	COG2346 Truncated hemoglobins
PIKALECD_01432	4.97e-219	yjbH	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
PIKALECD_01434	1.17e-258	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
PIKALECD_01435	1.11e-147	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
PIKALECD_01436	2.03e-87	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
PIKALECD_01438	6.86e-126	yjbC	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_01439	6.91e-296	-	-	-	S	-	-	-	Putative glycosyl hydrolase domain
PIKALECD_01440	1.34e-12	yoeD	-	-	G	-	-	-	Helix-turn-helix domain
PIKALECD_01441	3.02e-144	yplQ	-	-	S	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
PIKALECD_01442	1.76e-127	yueE	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
PIKALECD_01443	3.9e-131	-	-	-	CO	-	-	-	Redoxin
PIKALECD_01445	4.12e-228	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
PIKALECD_01446	1.94e-15	-	-	-	-	-	-	-	-
PIKALECD_01447	2.71e-181	yjbA	-	-	S	-	-	-	Belongs to the UPF0736 family
PIKALECD_01448	5.49e-197	yjaZ	-	-	O	-	-	-	Zn-dependent protease
PIKALECD_01449	2.48e-175	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	protein conserved in bacteria
PIKALECD_01450	2.13e-228	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
PIKALECD_01451	1.6e-171	ykwD	-	-	J	-	-	-	protein with SCP PR1 domains
PIKALECD_01452	1.58e-132	-	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell Wall Hydrolase
PIKALECD_01454	0.0	-	2.7.7.19, 2.7.7.72	-	J	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	Poly A polymerase head domain
PIKALECD_01455	7.41e-294	fabF	2.3.1.179	-	I	ko:K09458,ko:K14660	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
PIKALECD_01456	5.1e-213	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PIKALECD_01458	7.3e-19	comZ	-	-	S	ko:K02254	-	ko00000,ko02044	Competence protein ComG
PIKALECD_01459	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PIKALECD_01460	1.92e-201	-	5.1.3.2	-	GM	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
PIKALECD_01461	6.55e-155	yjaU	-	-	I	-	-	-	carboxylic ester hydrolase activity
PIKALECD_01462	3.63e-219	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PIKALECD_01463	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
PIKALECD_01464	6.21e-266	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
PIKALECD_01465	4.61e-271	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
PIKALECD_01466	3.18e-164	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
PIKALECD_01467	1.41e-284	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PIKALECD_01468	2.11e-249	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PIKALECD_01469	3.21e-212	ctaG	-	-	S	ko:K02862	-	ko00000	cytochrome c oxidase
PIKALECD_01470	1.24e-192	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
PIKALECD_01471	2.72e-102	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_01472	4.2e-139	-	-	-	-	-	-	-	-
PIKALECD_01473	3.57e-281	ywqB	-	-	S	-	-	-	zinc ion binding
PIKALECD_01474	0.0	ywqA	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
PIKALECD_01476	7.05e-17	-	-	-	S	-	-	-	Intracellular proteinase inhibitor
PIKALECD_01477	2.56e-186	yitT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
PIKALECD_01478	3.56e-188	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
PIKALECD_01479	9.73e-55	-	-	-	-	-	-	-	-
PIKALECD_01480	5.57e-83	ytwF	-	-	P	-	-	-	Sulfurtransferase
PIKALECD_01481	1.61e-115	-	-	-	-	-	-	-	-
PIKALECD_01482	0.0	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
PIKALECD_01483	5.47e-197	ykgA	-	-	E	-	-	-	Amidinotransferase
PIKALECD_01484	1.31e-63	-	-	-	S	-	-	-	IDEAL
PIKALECD_01485	0.0	asnH	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
PIKALECD_01486	7.36e-89	cheW	-	-	NT	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	chemotaxis
PIKALECD_01487	0.0	cheA	2.7.13.3	-	NT	ko:K03407	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	COG0643 Chemotaxis protein histidine kinase and related kinases
PIKALECD_01488	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
PIKALECD_01489	0.0	addB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	exonuclease activity
PIKALECD_01490	3.62e-79	-	-	-	-	-	-	-	-
PIKALECD_01491	1.67e-141	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
PIKALECD_01492	1.5e-184	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
PIKALECD_01493	7.44e-190	pstBA	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
PIKALECD_01494	2.52e-205	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
PIKALECD_01495	4.11e-203	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
PIKALECD_01496	5.74e-212	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
PIKALECD_01497	5.83e-100	-	-	-	S	-	-	-	DinB family
PIKALECD_01498	0.0	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
PIKALECD_01499	9e-166	-	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
PIKALECD_01500	1.64e-263	-	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
PIKALECD_01501	4.16e-150	ung2	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
PIKALECD_01503	1.88e-273	-	-	-	Q	-	-	-	COG1228 Imidazolonepropionase and related amidohydrolases
PIKALECD_01504	2.47e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	SpoVT / AbrB like domain
PIKALECD_01505	1.58e-59	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
PIKALECD_01506	5.37e-74	ysxB	-	-	J	ko:K07584	-	ko00000	ribosomal protein
PIKALECD_01507	5.22e-65	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
PIKALECD_01508	0.0	cafA	-	-	J	ko:K08301	-	ko00000,ko01000,ko03009,ko03019	ribonuclease, Rne Rng family
PIKALECD_01509	3.38e-172	spoIVFB	-	-	S	ko:K06402	-	ko00000,ko01000,ko01002	Stage IV sporulation protein
PIKALECD_01510	6.87e-163	spoIVFA	-	-	M	ko:K06401	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
PIKALECD_01511	1.93e-214	yqkF	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
PIKALECD_01512	3.2e-118	-	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
PIKALECD_01513	7.28e-96	-	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	MoaC family
PIKALECD_01514	1.99e-116	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
PIKALECD_01515	1.38e-182	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
PIKALECD_01516	2.21e-156	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
PIKALECD_01517	5.78e-101	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	shape-determining protein
PIKALECD_01518	3.28e-200	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
PIKALECD_01519	1.99e-238	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein MreB
PIKALECD_01520	2.9e-156	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
PIKALECD_01521	9.61e-131	maf	-	-	D	ko:K06287	-	ko00000	septum formation protein Maf
PIKALECD_01522	0.0	yuxL	3.4.19.1	-	EU	ko:K01303	-	ko00000,ko01000,ko01002	peptidase
PIKALECD_01523	9.58e-245	-	-	-	-	ko:K06380	-	ko00000	-
PIKALECD_01524	1.1e-146	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
PIKALECD_01525	1.01e-293	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
PIKALECD_01526	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
PIKALECD_01527	1.27e-37	-	-	-	-	-	-	-	-
PIKALECD_01528	4.38e-139	-	-	-	-	-	-	-	-
PIKALECD_01529	2.34e-240	ysxE	-	-	S	-	-	-	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PIKALECD_01530	4.48e-197	-	-	-	-	-	-	-	-
PIKALECD_01531	4.13e-228	spoVID	-	-	M	ko:K06417	-	ko00000	stage VI sporulation protein D
PIKALECD_01532	1.95e-309	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
PIKALECD_01533	1.05e-228	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the ALAD family
PIKALECD_01534	2.36e-168	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
PIKALECD_01535	5.95e-212	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
PIKALECD_01536	5.2e-186	hemX	-	-	O	ko:K02497	-	ko00000	cytochrome C
PIKALECD_01537	1.83e-316	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PIKALECD_01538	7.58e-140	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
PIKALECD_01539	0.0	lon	3.4.21.53	-	O	ko:K01338	ko04112,map04112	ko00000,ko00001,ko01000,ko01002	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PIKALECD_01540	0.0	lonB	3.4.21.53	-	LO	ko:K04076	-	ko00000,ko01000,ko01002	Belongs to the peptidase S16 family
PIKALECD_01541	2.85e-303	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PIKALECD_01542	3.13e-292	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
PIKALECD_01543	1.49e-228	ysoA	-	-	O	-	-	-	COG0457 FOG TPR repeat
PIKALECD_01544	2.02e-144	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PIKALECD_01545	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PIKALECD_01546	3.07e-243	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
PIKALECD_01547	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PIKALECD_01548	1.19e-233	ilvC	1.1.1.86	-	EH	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PIKALECD_01549	3.55e-110	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
PIKALECD_01550	0.0	ilvB	2.2.1.6	-	E	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
PIKALECD_01551	0.0	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
PIKALECD_01552	1.35e-92	-	-	-	-	-	-	-	-
PIKALECD_01553	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
PIKALECD_01554	0.0	cotA	1.16.3.3	-	Q	ko:K06324	-	ko00000,ko01000	multicopper oxidases
PIKALECD_01558	2.54e-122	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
PIKALECD_01559	9.56e-139	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PIKALECD_01560	1.89e-173	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PIKALECD_01561	1e-236	gerM	-	-	S	ko:K06298	-	ko00000	COG5401 Spore germination protein
PIKALECD_01562	1.79e-248	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
PIKALECD_01563	3.13e-42	-	-	-	C	-	-	-	4Fe-4S binding domain
PIKALECD_01564	1.01e-190	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
PIKALECD_01565	1.34e-103	ysmB	-	-	K	-	-	-	transcriptional
PIKALECD_01566	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PIKALECD_01567	2.33e-52	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPr
PIKALECD_01568	2.77e-45	gerE	-	-	K	ko:K01994	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_01569	2.52e-102	ysmA	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
PIKALECD_01570	1.2e-185	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
PIKALECD_01571	0.0	sdhA	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
PIKALECD_01572	5.12e-145	sdhC	-	-	C	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	succinate dehydrogenase
PIKALECD_01573	2.47e-293	ktrD	-	-	P	-	-	-	COG0168 Trk-type K transport systems, membrane components
PIKALECD_01574	7.17e-99	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
PIKALECD_01575	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
PIKALECD_01576	1.37e-70	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
PIKALECD_01577	4.22e-219	etfA	-	-	C	ko:K03522	-	ko00000,ko04147	Electron transfer flavoprotein
PIKALECD_01578	3.49e-172	etfB	-	-	C	ko:K03521	-	ko00000	Electron transfer flavoprotein
PIKALECD_01579	3.35e-170	fadB	4.2.1.17	-	I	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
PIKALECD_01580	1.59e-131	fadR	-	-	K	ko:K13770	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_01581	0.0	lcfA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PIKALECD_01582	4.19e-87	yshE	-	-	S	ko:K08989	-	ko00000	membrane
PIKALECD_01583	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
PIKALECD_01584	0.0	polX	-	-	L	ko:K02347	-	ko00000,ko03400	COG1796 DNA polymerase IV (family X)
PIKALECD_01585	8.3e-117	yshB	-	-	S	-	-	-	membrane protein, required for colicin V production
PIKALECD_01586	4.31e-44	zapA	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PIKALECD_01587	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
PIKALECD_01588	4.56e-244	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PIKALECD_01589	3.92e-164	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PIKALECD_01590	3.13e-42	sspI	-	-	S	ko:K06426	-	ko00000	Belongs to the SspI family
PIKALECD_01592	1.53e-24	-	-	-	-	-	-	-	-
PIKALECD_01593	8.37e-257	ysdC	-	-	G	-	-	-	COG1363 Cellulase M and related proteins
PIKALECD_01594	1.12e-85	ysdB	-	-	S	-	-	-	Sigma-w pathway protein YsdB
PIKALECD_01595	0.0	ywcA	-	-	S	ko:K14393	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PIKALECD_01596	9.32e-70	ywcB	-	-	S	-	-	-	Protein of unknown function, DUF485
PIKALECD_01597	5.42e-75	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PIKALECD_01598	3.08e-39	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
PIKALECD_01599	2.34e-110	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PIKALECD_01600	3.18e-264	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
PIKALECD_01601	3.26e-152	yknY	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_01602	6.4e-297	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PIKALECD_01603	1.04e-166	-	-	-	-	-	-	-	-
PIKALECD_01604	0.0	dacC	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
PIKALECD_01605	1.05e-224	-	-	-	C	-	-	-	Aldo/keto reductase family
PIKALECD_01606	3.42e-233	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_01607	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PIKALECD_01608	6.73e-208	ytxC	-	-	S	-	-	-	YtxC-like family
PIKALECD_01609	9.13e-284	mqnC	1.21.98.1	-	H	ko:K11784	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
PIKALECD_01610	1.66e-217	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
PIKALECD_01611	0.0	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
PIKALECD_01612	4.36e-103	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PIKALECD_01613	1.6e-85	-	-	-	-	-	-	-	-
PIKALECD_01614	1.05e-88	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PIKALECD_01615	6.76e-246	gapB	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
PIKALECD_01616	3.43e-127	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PIKALECD_01617	5.02e-134	ytaF	-	-	P	-	-	-	Probably functions as a manganese efflux pump
PIKALECD_01618	2.42e-198	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
PIKALECD_01619	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PIKALECD_01620	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase
PIKALECD_01621	2.8e-170	phoP	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_01622	2.74e-96	-	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	helix_turn_helix ASNC type
PIKALECD_01623	4.06e-216	mdh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible oxidation of malate to oxaloacetate
PIKALECD_01624	3.09e-306	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	isocitrate
PIKALECD_01625	5.73e-263	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
PIKALECD_01626	4.98e-96	-	-	-	S	-	-	-	UPF0756 membrane protein
PIKALECD_01627	1.17e-77	fxsA	-	-	S	ko:K07113	-	ko00000	COG3030 Protein affecting phage T7 exclusion by the F plasmid
PIKALECD_01628	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
PIKALECD_01629	3.27e-229	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
PIKALECD_01630	8.01e-228	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
PIKALECD_01631	9.45e-198	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PIKALECD_01632	2.38e-148	lutR_1	-	-	K	ko:K05799	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
PIKALECD_01633	4.23e-287	ytsJ	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
PIKALECD_01634	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
PIKALECD_01635	4.62e-70	ytrH	-	-	S	-	-	-	Sporulation protein YtrH
PIKALECD_01636	1.03e-117	ytrI	-	-	-	-	-	-	-
PIKALECD_01637	6.21e-213	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	COG0618 Exopolyphosphatase-related proteins
PIKALECD_01638	3.35e-11	ytpI	-	-	S	-	-	-	YtpI-like protein
PIKALECD_01639	2.37e-308	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
PIKALECD_01641	1.56e-161	ytkL	-	-	S	-	-	-	Belongs to the UPF0173 family
PIKALECD_01642	5.86e-255	ykvY	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
PIKALECD_01643	1.07e-82	-	-	-	-	-	-	-	-
PIKALECD_01644	4.14e-177	ytkK	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_01646	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
PIKALECD_01647	1.18e-294	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
PIKALECD_01649	1.03e-212	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	3'-5' exoribonuclease yhaM
PIKALECD_01650	2.04e-275	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PIKALECD_01651	1.33e-228	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
PIKALECD_01652	2.76e-110	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PIKALECD_01653	4.36e-251	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
PIKALECD_01654	1.19e-97	ytfJ	-	-	S	-	-	-	Sporulation protein YtfJ
PIKALECD_01655	3.98e-159	ytfI	-	-	S	-	-	-	Protein of unknown function (DUF2953)
PIKALECD_01656	6.34e-127	yteJ	-	-	S	-	-	-	RDD family
PIKALECD_01657	7.69e-228	sppA	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	signal peptide peptidase SppA
PIKALECD_01658	1.17e-38	-	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
PIKALECD_01659	1.78e-283	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PIKALECD_01660	1.07e-262	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
PIKALECD_01661	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
PIKALECD_01662	4.9e-179	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	COG1387 Histidinol phosphatase and related hydrolases of the PHP family
PIKALECD_01663	1.51e-146	yttP	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_01664	1.74e-112	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
PIKALECD_01665	4.92e-142	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PIKALECD_01666	1.24e-297	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PIKALECD_01667	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
PIKALECD_01668	0.0	acsA	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
PIKALECD_01669	2.34e-154	acuA	-	-	K	ko:K04766	-	ko00000,ko01000	Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
PIKALECD_01670	1.55e-142	acuB	-	-	S	ko:K04767	-	ko00000	Acetoin utilization protein AcuB
PIKALECD_01671	1.95e-294	acuC	-	-	BQ	ko:K04768	-	ko00000	histone deacetylase
PIKALECD_01672	3.72e-237	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
PIKALECD_01673	1.67e-251	aroA	2.5.1.54, 5.4.99.5	-	E	ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
PIKALECD_01674	1.14e-27	ytxH	-	-	S	-	-	-	COG4980 Gas vesicle protein
PIKALECD_01675	1.68e-84	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PIKALECD_01676	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
PIKALECD_01677	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
PIKALECD_01678	1.57e-134	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
PIKALECD_01679	1.62e-186	ytpQ	-	-	S	-	-	-	Belongs to the UPF0354 family
PIKALECD_01680	1.15e-73	ytpP	-	-	CO	-	-	-	Thioredoxin
PIKALECD_01681	1.06e-183	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
PIKALECD_01682	7.88e-100	ytoQ	-	-	S	-	-	-	Nucleoside 2-deoxyribosyltransferase YtoQ
PIKALECD_01683	6.99e-112	yjjX	-	-	F	-	-	-	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PIKALECD_01684	4.52e-262	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
PIKALECD_01685	5.27e-64	ytzB	-	-	-	-	-	-	-
PIKALECD_01686	2.52e-155	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
PIKALECD_01688	9.14e-197	ytmP	-	-	M	-	-	-	Phosphotransferase
PIKALECD_01689	1.04e-209	purU	3.5.1.10	-	F	ko:K01433	ko00630,ko00670,map00630,map00670	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
PIKALECD_01690	2.27e-161	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_01691	7.62e-68	-	-	-	S	-	-	-	PFAM Uncharacterised protein family UPF0150
PIKALECD_01692	1.65e-268	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
PIKALECD_01693	6.01e-246	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
PIKALECD_01694	1.28e-224	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
PIKALECD_01695	6.62e-262	lpdA	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PIKALECD_01696	0.0	acoR	-	-	KQ	ko:K21405	-	ko00000,ko03000	COG3284 Transcriptional activator of acetoin glycerol metabolism
PIKALECD_01697	1.19e-143	cidB	-	-	M	-	-	-	effector of murein hydrolase
PIKALECD_01698	1.52e-79	-	-	-	S	ko:K06518	-	ko00000,ko02000	Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
PIKALECD_01699	2.67e-130	ytlP	3.1.4.58	-	J	ko:K01975	-	ko00000,ko01000,ko03016	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PIKALECD_01700	9.53e-213	ytkP	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
PIKALECD_01701	1.15e-204	ydeE	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
PIKALECD_01702	7.71e-138	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_01703	1.82e-207	-	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
PIKALECD_01704	6.52e-98	fosB	-	-	H	ko:K11210,ko:K21252	-	ko00000,ko01000,ko01504	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
PIKALECD_01705	4.69e-43	ytzE	-	-	K	-	-	-	COG1349 Transcriptional regulators of sugar metabolism
PIKALECD_01706	7.12e-170	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
PIKALECD_01707	4.05e-266	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
PIKALECD_01708	6.54e-253	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
PIKALECD_01709	0.0	ytgP	-	-	S	ko:K03328,ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PIKALECD_01710	4.21e-208	yvrE	-	-	G	ko:K14274	ko00040,map00040	ko00000,ko00001,ko01000	SMP-30/Gluconolaconase/LRE-like region
PIKALECD_01711	1.72e-90	yugU	-	-	S	-	-	-	Uncharacterised protein family UPF0047
PIKALECD_01712	1.46e-287	yhaA1	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
PIKALECD_01713	1.04e-259	ytfP	-	-	S	ko:K07007	-	ko00000	HI0933-like protein
PIKALECD_01714	1.12e-99	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
PIKALECD_01715	9.49e-169	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
PIKALECD_01716	4.22e-305	-	-	-	S	ko:K12941	-	ko00000,ko01002	amidohydrolase
PIKALECD_01717	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
PIKALECD_01718	4.83e-142	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
PIKALECD_01719	5.36e-65	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
PIKALECD_01720	1.95e-244	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
PIKALECD_01722	4.92e-130	ytqB	-	-	J	-	-	-	Putative rRNA methylase
PIKALECD_01723	9.47e-137	yvdA	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
PIKALECD_01724	1.3e-194	ytpA	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
PIKALECD_01725	6.24e-94	ytoA	-	-	S	-	-	-	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PIKALECD_01726	5.77e-287	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PIKALECD_01727	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PIKALECD_01728	4.87e-190	ytmA	-	-	E	-	-	-	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
PIKALECD_01729	3.41e-231	ytlA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
PIKALECD_01730	6.58e-175	ytlC	3.6.3.36	-	P	ko:K02049,ko:K10831,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
PIKALECD_01731	1.53e-175	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
PIKALECD_01732	8.3e-110	ytkD	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
PIKALECD_01733	2.62e-283	ymfD	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
PIKALECD_01734	2.1e-109	ywpF	-	-	S	-	-	-	YwpF-like protein
PIKALECD_01736	2.91e-279	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
PIKALECD_01737	2.15e-144	dgk	2.7.1.113	-	F	ko:K15518	ko00230,map00230	ko00000,ko00001,ko01000	Deoxyguanosine kinase
PIKALECD_01738	1.78e-153	dck	2.7.1.74, 2.7.1.76	-	F	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko01000	Deoxycytidine kinase
PIKALECD_01739	3.1e-136	-	-	-	V	ko:K07448	-	ko00000,ko02048	Restriction endonuclease
PIKALECD_01740	5.59e-223	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4607 ABC-type enterochelin transport system, periplasmic component
PIKALECD_01741	6.89e-192	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
PIKALECD_01742	5.22e-197	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_01743	1.01e-206	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_01744	1.17e-128	pgpB3	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	COG0671 Membrane-associated phospholipid phosphatase
PIKALECD_01745	1.09e-294	tcyP	-	-	U	ko:K06956	-	ko00000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PIKALECD_01746	1.55e-99	-	-	-	S	-	-	-	Putative small multi-drug export protein
PIKALECD_01747	1.4e-95	-	-	-	S	-	-	-	DinB superfamily
PIKALECD_01748	1.34e-76	-	-	-	S	-	-	-	Protein of unknown function (DUF1516)
PIKALECD_01749	1.42e-108	yneJ	-	-	O	-	-	-	COG4846 Membrane protein involved in cytochrome C biogenesis
PIKALECD_01750	6.95e-211	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
PIKALECD_01751	1.46e-212	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
PIKALECD_01754	2.25e-29	-	-	-	-	-	-	-	-
PIKALECD_01755	5.09e-93	yugN	-	-	S	-	-	-	YugN-like family
PIKALECD_01756	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
PIKALECD_01757	7.51e-262	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
PIKALECD_01758	2e-287	yugJ	-	-	C	ko:K19955	-	ko00000,ko01000	oxidoreductases, Fe-dependent alcohol dehydrogenase family
PIKALECD_01759	2.41e-45	yuzA	-	-	S	ko:K09779	-	ko00000	Domain of unknown function (DUF378)
PIKALECD_01760	7.86e-77	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
PIKALECD_01761	3.53e-256	yfmL	-	-	L	-	-	-	COG0513 Superfamily II DNA and RNA helicases
PIKALECD_01762	1.17e-172	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PIKALECD_01763	3.31e-283	yugH	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Aminotransferase
PIKALECD_01764	7.3e-111	alaR	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_01765	4.49e-112	luxS	4.4.1.21	-	T	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
PIKALECD_01766	6.56e-187	-	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
PIKALECD_01767	1.81e-55	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
PIKALECD_01768	1.56e-296	yuiF	-	-	S	ko:K07084	-	ko00000,ko02000	antiporter
PIKALECD_01769	5.93e-60	-	-	-	-	-	-	-	-
PIKALECD_01770	0.0	pepA	3.4.11.1	-	E	ko:K01255	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PIKALECD_01771	2.77e-102	yuiD	-	-	S	ko:K09775	-	ko00000	protein conserved in bacteria
PIKALECD_01772	1.84e-140	yuiC	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01773	2.61e-61	yuiB	-	-	S	-	-	-	Putative membrane protein
PIKALECD_01774	2.2e-293	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
PIKALECD_01775	3.18e-237	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	reductase
PIKALECD_01776	3.34e-266	mtlD	1.1.1.17	-	G	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	COG0246 Mannitol-1-phosphate altronate dehydrogenases
PIKALECD_01777	5e-96	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
PIKALECD_01778	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	transcriptional regulator, MtlR
PIKALECD_01779	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
PIKALECD_01780	3.3e-198	-	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
PIKALECD_01781	1.16e-139	yckA	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
PIKALECD_01782	7.18e-79	yutM	-	-	S	ko:K13628	-	ko00000,ko03016	Belongs to the HesB IscA family
PIKALECD_01783	1.47e-266	mqnE	2.5.1.120	-	H	ko:K18285	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PIKALECD_01784	3.2e-206	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PIKALECD_01785	9.92e-57	-	-	-	-	-	-	-	-
PIKALECD_01786	3.63e-54	yuzB	-	-	S	-	-	-	Belongs to the UPF0349 family
PIKALECD_01787	0.0	yutJ	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
PIKALECD_01788	6.51e-69	yuzD	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01789	4.25e-49	yutI	-	-	O	-	-	-	COG0694 Thioredoxin-like proteins and domains
PIKALECD_01790	7.53e-208	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
PIKALECD_01791	2.38e-252	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PIKALECD_01792	7.92e-306	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
PIKALECD_01793	2.16e-268	yutH	-	-	S	-	-	-	Spore coat protein
PIKALECD_01794	1.37e-109	yutG	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
PIKALECD_01795	1.68e-176	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
PIKALECD_01796	5.75e-103	yutE	-	-	S	-	-	-	Protein of unknown function DUF86
PIKALECD_01797	1.79e-59	-	-	-	-	-	-	-	-
PIKALECD_01798	6.09e-67	yutD	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01799	1.68e-121	yutC	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PIKALECD_01800	4.43e-222	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PIKALECD_01801	4.04e-255	lytH	-	-	M	ko:K21472	-	ko00000,ko01000,ko01002,ko01011	Peptidase, M23
PIKALECD_01802	0.0	-	-	-	C	ko:K18218	-	ko00000,ko00002,ko01504,ko02000	Na+/H+ antiporter family
PIKALECD_01803	5.21e-178	yunB	-	-	S	-	-	-	Sporulation protein YunB (Spo_YunB)
PIKALECD_01804	2.2e-115	dfrA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PIKALECD_01805	2.84e-200	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PIKALECD_01806	7.97e-65	yunC	-	-	S	-	-	-	Domain of unknown function (DUF1805)
PIKALECD_01807	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
PIKALECD_01808	7.59e-175	yunE	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
PIKALECD_01809	3.22e-211	yunF	-	-	S	-	-	-	Protein of unknown function DUF72
PIKALECD_01810	4.78e-77	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_01811	1.71e-131	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_01812	4.68e-82	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
PIKALECD_01813	1.58e-68	-	-	-	-	-	-	-	-
PIKALECD_01814	2.07e-164	-	-	-	-	-	-	-	-
PIKALECD_01816	1.25e-54	-	-	-	-	-	-	-	-
PIKALECD_01817	2.64e-56	-	-	-	-	-	-	-	-
PIKALECD_01818	6.28e-58	-	-	-	-	-	-	-	-
PIKALECD_01820	2.94e-51	-	-	-	-	-	-	-	-
PIKALECD_01821	3.47e-193	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_01822	1.85e-58	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
PIKALECD_01823	3.33e-42	-	-	-	S	-	-	-	Pathogenicity locus
PIKALECD_01824	9.29e-103	-	-	-	H	-	-	-	RibD C-terminal domain
PIKALECD_01825	9.07e-198	-	-	-	S	-	-	-	Phosphotransferase enzyme family
PIKALECD_01826	2.32e-117	yvbU	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_01827	5.4e-143	-	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
PIKALECD_01828	3.1e-222	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
PIKALECD_01829	3.71e-173	msmR	-	-	K	-	-	-	AraC family transcriptional regulator
PIKALECD_01830	2.42e-236	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
PIKALECD_01831	6.93e-178	-	-	-	Q	-	-	-	Methyltransferase domain
PIKALECD_01832	5.7e-272	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
PIKALECD_01833	1.55e-298	bglH7	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
PIKALECD_01834	0.0	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_01835	1.64e-154	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
PIKALECD_01836	1.51e-23	-	-	-	S	-	-	-	YhfH-like protein
PIKALECD_01837	2.73e-301	aceA	4.1.3.1	-	C	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Isocitrate lyase
PIKALECD_01838	7.28e-117	-	-	-	T	-	-	-	Transcriptional regulator
PIKALECD_01839	1.36e-195	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_01840	6.99e-98	nodB1	-	-	G	-	-	-	deacetylase
PIKALECD_01841	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	FeS cluster assembly
PIKALECD_01842	2.18e-101	nifU	-	-	C	ko:K04488	-	ko00000	COG0822 NifU homolog involved in Fe-S cluster formation
PIKALECD_01843	1.44e-297	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PIKALECD_01844	5.41e-310	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
PIKALECD_01845	8.04e-186	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
PIKALECD_01846	4.09e-80	yurZ	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PIKALECD_01847	1.52e-212	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
PIKALECD_01848	1.55e-122	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
PIKALECD_01849	1.39e-197	metQ	-	-	P	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
PIKALECD_01850	8.61e-147	metI	-	-	P	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
PIKALECD_01851	1.82e-233	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PIKALECD_01852	6.74e-84	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
PIKALECD_01853	1.61e-81	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
PIKALECD_01854	0.0	fadE	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
PIKALECD_01855	6.85e-271	fadA	2.3.1.16	-	I	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the thiolase family
PIKALECD_01856	0.0	fadN	1.1.1.35	-	I	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	ko00000,ko00001,ko00002,ko01000	3-hydroxyacyl-CoA dehydrogenase
PIKALECD_01857	3e-274	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
PIKALECD_01858	0.0	-	-	-	S	-	-	-	Sugar transport-related sRNA regulator N-term
PIKALECD_01859	2.8e-154	-	-	-	S	-	-	-	Glycosyltransferase like family
PIKALECD_01861	6.85e-07	-	-	-	-	-	-	-	-
PIKALECD_01862	2.62e-139	lip	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PIKALECD_01864	4.58e-306	gabT	2.6.1.19	-	E	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PIKALECD_01865	2.86e-305	-	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01866	3.58e-74	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_01867	3.89e-99	-	-	-	-	-	-	-	-
PIKALECD_01868	1.21e-18	-	-	-	G	ko:K08225	-	ko00000,ko02000	transmembrane transporter activity
PIKALECD_01874	1.12e-104	smpB	-	-	O	ko:K03664	-	ko00000	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PIKALECD_01875	2.07e-79	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_01876	2.03e-78	-	-	-	S	ko:K15977	-	ko00000	DoxX
PIKALECD_01877	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
PIKALECD_01878	1.24e-177	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Carboxylesterase
PIKALECD_01879	1.06e-176	-	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	COG1647 Esterase lipase
PIKALECD_01880	1.05e-224	yceB	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PIKALECD_01881	1.94e-37	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
PIKALECD_01882	4.54e-100	yclD	-	-	-	-	-	-	-
PIKALECD_01883	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
PIKALECD_01884	1.43e-95	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
PIKALECD_01885	3.2e-218	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
PIKALECD_01886	1.72e-285	-	4.2.1.158	-	M	ko:K20022	-	ko00000,ko01000	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PIKALECD_01887	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_01888	1.49e-223	-	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
PIKALECD_01889	7.63e-156	-	-	-	K	-	-	-	FCD
PIKALECD_01890	9.59e-305	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
PIKALECD_01891	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of 2-phosphoglycerate and
PIKALECD_01892	3.1e-168	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
PIKALECD_01893	3e-272	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
PIKALECD_01894	4.9e-239	gapA	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
PIKALECD_01895	4.28e-230	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
PIKALECD_01896	1.02e-257	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_01898	2.48e-52	XAC3035	-	-	O	ko:K06191	-	ko00000	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PIKALECD_01899	2.2e-293	sigL	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
PIKALECD_01901	6.73e-133	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
PIKALECD_01902	0.0	-	-	-	L	-	-	-	COG3666 Transposase and inactivated derivatives
PIKALECD_01903	1.39e-106	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
PIKALECD_01904	6.5e-289	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PIKALECD_01905	7.43e-144	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
PIKALECD_01906	3.24e-246	-	-	-	I	-	-	-	3-hydroxyisobutyryl-CoA hydrolase
PIKALECD_01907	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_01908	7.41e-201	hgd	1.1.1.31, 1.1.1.60	-	I	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	ko00000,ko00001,ko01000	3-hydroxyisobutyrate dehydrogenase
PIKALECD_01909	8.73e-205	prpB	4.1.3.30, 5.4.2.9	-	G	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PIKALECD_01910	0.0	prpD	4.2.1.79	-	S	ko:K01720	ko00640,map00640	ko00000,ko00001,ko01000	2-methylcitrate dehydratase
PIKALECD_01911	2e-264	mmgD	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
PIKALECD_01912	1.7e-259	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
PIKALECD_01913	1.91e-202	ccpC	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_01914	5.51e-83	ytaB	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	membrane
PIKALECD_01915	4.61e-106	ppiB	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PIKALECD_01916	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
PIKALECD_01917	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Stage V sporulation protein AF
PIKALECD_01918	2.55e-137	spoVAEA	-	-	S	ko:K06407	-	ko00000	Stage V sporulation protein AE
PIKALECD_01919	5.03e-75	-	-	-	S	ko:K06407	-	ko00000	Pfam:SpoVA
PIKALECD_01920	5.67e-233	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
PIKALECD_01921	5.87e-104	-	-	-	S	ko:K06405	-	ko00000	Pfam:SpoVA
PIKALECD_01922	7.67e-175	sigF	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_01923	3.77e-97	spoIIAB	2.7.11.1	-	F	ko:K06379	-	ko00000,ko01000	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
PIKALECD_01924	7.27e-73	spoIIAA	-	-	T	ko:K06378	-	ko00000	Belongs to the anti-sigma-factor antagonist family
PIKALECD_01925	1.21e-268	dacF	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
PIKALECD_01926	1.42e-176	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
PIKALECD_01927	2.22e-108	yvsG	-	-	S	ko:K07038	-	ko00000	LexA-binding, inner membrane-associated putative hydrolase
PIKALECD_01928	1.68e-69	-	-	-	-	-	-	-	-
PIKALECD_01929	3.18e-29	yycD	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
PIKALECD_01930	2.08e-302	ycnB	-	-	EGP	-	-	-	the major facilitator superfamily
PIKALECD_01931	3.49e-139	yqfW	-	-	S	ko:K05967	-	ko00000	Belongs to the 5'(3')-deoxyribonucleotidase family
PIKALECD_01932	5e-83	yqfX	-	-	S	-	-	-	membrane
PIKALECD_01933	1.01e-254	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PIKALECD_01934	8.72e-71	fimV	-	-	NU	ko:K08086,ko:K15845	ko05120,map05120	ko00000,ko00001	translation initiation factor activity
PIKALECD_01935	7.02e-227	-	-	-	EGP	ko:K08221	-	ko00000,ko02000	Sugar (and other) transporter
PIKALECD_01936	3.64e-193	ypuA	-	-	S	-	-	-	Secreted protein
PIKALECD_01937	7.69e-147	-	-	-	O	-	-	-	NfeD-like C-terminal, partner-binding
PIKALECD_01938	2.56e-248	XK27_00915	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PIKALECD_01939	0.0	yjbB	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
PIKALECD_01945	1.93e-149	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
PIKALECD_01946	4.14e-295	yqgE	-	-	EGP	ko:K08222	-	ko00000,ko02000	Major facilitator superfamily
PIKALECD_01948	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	penicillin-binding protein
PIKALECD_01949	2.77e-98	-	-	-	S	-	-	-	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PIKALECD_01950	5.25e-79	-	-	-	-	-	-	-	-
PIKALECD_01951	2.9e-158	-	-	-	G	-	-	-	PFAM Glycoside hydrolase 15-related
PIKALECD_01952	6.04e-27	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
PIKALECD_01953	2.01e-121	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PIKALECD_01954	5.39e-181	-	-	-	S	-	-	-	Integral membrane protein DUF92
PIKALECD_01955	3.31e-238	moeB	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
PIKALECD_01956	3.2e-303	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
PIKALECD_01958	0.0	gluP	3.4.21.105	-	O	ko:K19225	-	ko00000,ko01000,ko01002	membrane protein (homolog of Drosophila rhomboid)
PIKALECD_01959	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Bacillus/Clostridium GerA spore germination protein
PIKALECD_01960	7.09e-88	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
PIKALECD_01961	2.14e-105	-	-	-	-	-	-	-	-
PIKALECD_01962	1.37e-10	yqgQ	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01963	5.13e-222	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
PIKALECD_01964	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Aspartate ammonia-lyase
PIKALECD_01965	9.41e-140	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
PIKALECD_01966	1.28e-37	-	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	ThiS family
PIKALECD_01967	2.03e-179	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
PIKALECD_01968	5.52e-264	thiO	1.4.3.19	-	E	ko:K03153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Glycine oxidase
PIKALECD_01969	4.06e-179	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
PIKALECD_01970	6.28e-124	-	-	-	-	-	-	-	-
PIKALECD_01971	6.41e-238	yqgV	-	-	S	-	-	-	Thiamine-binding protein
PIKALECD_01972	4.13e-92	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_01973	3.32e-119	yjcG	-	-	J	-	-	-	Belongs to the 2H phosphoesterase superfamily. YjcG family
PIKALECD_01974	1.5e-171	yjcH	-	-	P	ko:K07214	-	ko00000	COG2382 Enterochelin esterase and related enzymes
PIKALECD_01975	4.16e-42	-	-	-	-	-	-	-	-
PIKALECD_01976	3.54e-67	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_01977	2.58e-41	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
PIKALECD_01978	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
PIKALECD_01979	5.19e-103	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
PIKALECD_01980	3.22e-119	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PIKALECD_01981	1.1e-82	pbuO_1	-	-	S	ko:K06901	-	ko00000,ko02000	permease
PIKALECD_01982	5.53e-24	pbuO_1	-	-	S	ko:K06901	-	ko00000,ko02000	Permease
PIKALECD_01983	4.53e-216	-	-	-	F	-	-	-	GHKL domain
PIKALECD_01984	1.84e-214	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
PIKALECD_01985	3.45e-121	yqjB	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_01987	5.72e-90	mce	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0346 Lactoylglutathione lyase and related lyases
PIKALECD_01988	1.86e-247	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	COG2195 Di- and tripeptidases
PIKALECD_01989	1.1e-120	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
PIKALECD_01991	1.95e-89	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
PIKALECD_01992	4.89e-102	-	-	-	S	-	-	-	Pfam Polyketide cyclase dehydrase and lipid transport
PIKALECD_01993	7.08e-96	ykuL	-	-	S	-	-	-	CBS domain
PIKALECD_01994	1.01e-55	-	-	-	-	-	-	-	-
PIKALECD_01995	0.0	apr	-	-	O	-	-	-	Belongs to the peptidase S8 family
PIKALECD_01996	2.52e-174	yibQ	-	-	S	ko:K09798	-	ko00000	protein conserved in bacteria
PIKALECD_01997	3.57e-62	tnrA	-	-	K	-	-	-	transcriptional
PIKALECD_01998	3.09e-66	-	-	-	-	-	-	-	-
PIKALECD_02000	3.56e-314	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
PIKALECD_02001	2.91e-161	-	-	-	P	ko:K08714	-	ko00000,ko02000	Polycystin cation channel
PIKALECD_02002	2.96e-182	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PIKALECD_02003	3.1e-287	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PIKALECD_02004	7.22e-262	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PIKALECD_02005	0.0	asnO	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
PIKALECD_02006	1.51e-233	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
PIKALECD_02007	1.02e-105	-	-	-	V	-	-	-	COG4767 Glycopeptide antibiotics resistance protein
PIKALECD_02008	1.48e-69	ogt	-	-	L	ko:K07443	-	ko00000	Methyltransferase
PIKALECD_02009	2.79e-125	yvbF	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
PIKALECD_02010	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PIKALECD_02011	2.51e-46	ynzC	-	-	S	-	-	-	UPF0291 protein
PIKALECD_02012	1.62e-148	yneB	-	-	L	-	-	-	resolvase
PIKALECD_02014	8.11e-145	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PIKALECD_02015	3.58e-282	yuxJ	-	-	EGP	-	-	-	Major facilitator superfamily
PIKALECD_02017	4.77e-214	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PIKALECD_02018	3.38e-12	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PIKALECD_02020	9.04e-120	-	-	-	FG	-	-	-	Domain of unknown function (DUF4269)
PIKALECD_02021	3.65e-63	-	-	-	-	-	-	-	-
PIKALECD_02022	1.97e-174	-	-	-	K	-	-	-	helix_turn_helix isocitrate lyase regulation
PIKALECD_02023	1.18e-178	-	-	-	Q	-	-	-	Domain of unknown function (DUF2437)
PIKALECD_02024	0.0	glcB	2.3.3.9	-	C	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PIKALECD_02025	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
PIKALECD_02026	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
PIKALECD_02027	1.47e-273	-	-	-	C	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	FAD binding domain
PIKALECD_02028	0.0	-	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
PIKALECD_02029	7.17e-276	-	-	-	G	-	-	-	ABC transporter substrate-binding protein
PIKALECD_02030	9.96e-159	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
PIKALECD_02031	8.57e-172	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Sugar ABC transporter ATPase
PIKALECD_02032	5.37e-287	-	-	-	K	-	-	-	AraC family transcriptional regulator
PIKALECD_02034	7.81e-131	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
PIKALECD_02035	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
PIKALECD_02036	1.15e-301	ynbB	-	-	P	-	-	-	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
PIKALECD_02037	1.66e-219	spoVK	-	-	O	ko:K06413	-	ko00000	stage V sporulation protein K
PIKALECD_02038	1.48e-230	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
PIKALECD_02039	1.24e-47	hfq	-	-	J	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	ko00000,ko00001,ko03019,ko03036	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
PIKALECD_02040	3.47e-215	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PIKALECD_02041	1.73e-172	-	-	-	J	-	-	-	Putative SAM-dependent methyltransferase
PIKALECD_02042	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PIKALECD_02043	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PIKALECD_02044	1.13e-133	cotE	-	-	S	ko:K06328	-	ko00000	Spore coat protein
PIKALECD_02045	3.04e-86	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
PIKALECD_02046	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PIKALECD_02047	1.03e-195	tgl	2.3.2.13	-	H	ko:K00686	-	ko00000,ko01000	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
PIKALECD_02048	7.82e-51	spoVS	-	-	S	ko:K06416	-	ko00000	Stage V sporulation protein S
PIKALECD_02049	1.76e-190	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
PIKALECD_02050	3.81e-293	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
PIKALECD_02051	1.81e-147	-	-	-	L	-	-	-	DNA recombination
PIKALECD_02052	8.1e-10	-	-	-	-	-	-	-	-
PIKALECD_02053	0.0	-	-	-	L	-	-	-	AAA domain
PIKALECD_02054	9.51e-239	-	-	-	L	-	-	-	Calcineurin-like phosphoesterase superfamily domain
PIKALECD_02055	3.46e-242	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PIKALECD_02056	0.0	deaD	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
PIKALECD_02057	8.15e-284	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
PIKALECD_02058	2.85e-128	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PIKALECD_02059	4.82e-180	ymfM	-	-	S	ko:K15539	-	ko00000	protein conserved in bacteria
PIKALECD_02060	5.43e-180	ymfK	-	-	S	-	-	-	Protein of unknown function (DUF3388)
PIKALECD_02061	4.23e-49	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1540)
PIKALECD_02062	1.06e-99	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
PIKALECD_02063	2.12e-179	zurM	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
PIKALECD_02064	3.99e-183	zurA	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
PIKALECD_02065	3.27e-168	-	-	-	M	-	-	-	Transglycosylase SLT domain
PIKALECD_02066	4.61e-273	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
PIKALECD_02068	1.03e-207	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PIKALECD_02069	9.18e-317	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
PIKALECD_02070	2.52e-87	yqfQ	-	-	S	-	-	-	YqfQ-like protein
PIKALECD_02071	5.53e-110	-	-	-	K	ko:K07736	-	ko00000,ko03000	Transcription factor
PIKALECD_02072	3.02e-227	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PIKALECD_02073	1.48e-250	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PIKALECD_02074	2.63e-151	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
PIKALECD_02075	6.91e-84	cccA	-	-	C	ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
PIKALECD_02076	1.45e-257	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
PIKALECD_02077	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
PIKALECD_02078	2.23e-102	yqxD	-	-	S	ko:K09768	-	ko00000	Belongs to the UPF0178 family
PIKALECD_02079	1.01e-183	yqfL	2.7.11.33, 2.7.4.28	-	S	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
PIKALECD_02080	5.23e-144	ccpN	-	-	K	-	-	-	CBS domain
PIKALECD_02081	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
PIKALECD_02082	4.79e-219	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
PIKALECD_02083	1.14e-177	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
PIKALECD_02084	2.53e-25	-	-	-	S	-	-	-	YqzL-like protein
PIKALECD_02085	8.21e-215	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PIKALECD_02086	2.61e-91	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
PIKALECD_02087	1.82e-80	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
PIKALECD_02088	1.88e-106	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PIKALECD_02089	0.0	yqfF	-	-	S	ko:K07037	-	ko00000	membrane-associated HD superfamily hydrolase
PIKALECD_02090	2.65e-220	phoH	-	-	T	ko:K06217	-	ko00000	Phosphate starvation-inducible protein PhoH
PIKALECD_02091	7.45e-278	yqfD	-	-	S	ko:K06438	-	ko00000	Stage IV sporulation
PIKALECD_02092	1e-62	yqfC	-	-	S	-	-	-	sporulation protein YqfC
PIKALECD_02093	2.7e-84	-	-	-	-	-	-	-	-
PIKALECD_02094	1.34e-153	yqfA	-	-	S	-	-	-	UPF0365 protein
PIKALECD_02095	8.29e-282	yqeZ	-	-	O	ko:K07403	-	ko00000	COG1030 Membrane-bound serine protease (ClpP class)
PIKALECD_02096	3.16e-92	yqeY	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
PIKALECD_02097	1.03e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
PIKALECD_02098	1.39e-204	yqeW	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
PIKALECD_02099	3.62e-217	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
PIKALECD_02100	7.06e-147	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PIKALECD_02101	9.81e-280	gltT	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PIKALECD_02102	8.58e-172	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
PIKALECD_02103	0.0	yqeV	2.8.4.5	-	J	ko:K18707	-	ko00000,ko01000,ko03016	ribosomal protein S12 methylthiotransferase
PIKALECD_02104	1.43e-167	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
PIKALECD_02105	7.26e-215	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Methylates ribosomal protein L11
PIKALECD_02106	3.2e-265	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
PIKALECD_02107	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
PIKALECD_02108	2.88e-110	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PIKALECD_02109	4.19e-239	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
PIKALECD_02110	1.24e-277	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
PIKALECD_02111	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
PIKALECD_02112	8.8e-70	-	-	-	-	-	-	-	-
PIKALECD_02113	3.58e-263	spoIIP	-	-	M	ko:K06385	-	ko00000	stage II sporulation protein P
PIKALECD_02114	2.07e-261	gpr	3.4.24.78	-	C	ko:K06012	-	ko00000,ko01000,ko01002	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PIKALECD_02115	1.15e-48	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
PIKALECD_02116	0.0	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PIKALECD_02117	0.0	malP	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_02118	6.86e-177	glvR	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
PIKALECD_02119	1.36e-95	-	-	-	-	-	-	-	-
PIKALECD_02121	4.26e-109	-	-	-	S	-	-	-	Protein of unknown function with HXXEE motif
PIKALECD_02122	5.4e-48	yqjY	-	-	K	ko:K06977	-	ko00000	Acetyltransferase (GNAT) domain
PIKALECD_02123	7.63e-221	lacC	2.7.1.144	-	G	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
PIKALECD_02124	8.33e-183	-	-	-	K	ko:K02530	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
PIKALECD_02125	2.28e-102	-	2.7.1.200	-	GT	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_02126	2.76e-55	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
PIKALECD_02127	1.44e-311	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	COG3775 Phosphotransferase system, galactitol-specific IIC component
PIKALECD_02128	8.88e-246	-	1.1.1.14, 1.1.1.251	-	C	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	ko00000,ko00001,ko00002,ko01000	Alcohol dehydrogenase GroES-like domain
PIKALECD_02129	4.86e-200	kbaY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
PIKALECD_02130	3.17e-71	yyaQ	-	-	S	-	-	-	Protein conserved in bacteria
PIKALECD_02131	6.75e-130	folE2	3.5.4.16	-	S	ko:K09007	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Converts GTP to 7,8-dihydroneopterin triphosphate
PIKALECD_02132	1.27e-77	yoaS	-	-	S	-	-	-	membrane
PIKALECD_02133	5.02e-39	-	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02134	5.27e-177	yoaT	-	-	S	-	-	-	Protein of unknown function (DUF817)
PIKALECD_02135	0.0	pps	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphoenolpyruvate synthase
PIKALECD_02136	6e-74	-	-	-	S	-	-	-	Protein of unknown function (DUF664)
PIKALECD_02137	2.33e-152	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_02138	8.69e-49	-	-	-	T	-	-	-	helix_turn_helix, arabinose operon control protein
PIKALECD_02140	3.05e-169	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein
PIKALECD_02141	4.61e-150	-	-	-	G	-	-	-	Binding-protein-dependent transport system inner membrane component
PIKALECD_02142	2.03e-136	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02143	0.0	ramA	3.2.1.40	-	G	ko:K05989	-	ko00000,ko01000	Alpha-L-rhamnosidase
PIKALECD_02144	8.95e-27	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PIKALECD_02145	1.1e-115	-	-	-	K	-	-	-	Helix-turn-helix domain
PIKALECD_02146	4.7e-251	rspA	4.2.1.8	-	M	ko:K08323	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
PIKALECD_02147	1.47e-228	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_02149	6.37e-261	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_02150	7.04e-99	M1-574	-	-	T	-	-	-	Response regulator containing CheY-like receiver and SARP domains
PIKALECD_02151	0.0	-	-	-	M	-	-	-	cell wall anchor domain
PIKALECD_02152	1.6e-127	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
PIKALECD_02153	1.01e-313	-	-	-	G	ko:K02027,ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_02155	6.65e-204	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_02156	1.2e-240	-	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
PIKALECD_02157	3.89e-241	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_02158	3.8e-106	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_02159	2.52e-283	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_02160	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
PIKALECD_02161	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
PIKALECD_02162	0.0	-	-	-	K	ko:K03491	-	ko00000,ko03000	transcriptional regulator, MtlR
PIKALECD_02163	1.98e-200	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
PIKALECD_02164	1.97e-92	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_02165	6.25e-63	-	2.7.1.202	-	G	ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_02166	3.03e-237	fruA2	-	-	G	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase System
PIKALECD_02167	3.34e-119	ydaE	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Cupin 2, conserved barrel domain protein
PIKALECD_02169	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PIKALECD_02170	1.2e-203	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PIKALECD_02171	7.86e-132	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PIKALECD_02172	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
PIKALECD_02173	4.35e-300	-	-	-	E	-	-	-	Acyclic terpene utilisation family protein AtuA
PIKALECD_02174	1.96e-65	-	-	-	-	-	-	-	-
PIKALECD_02175	1.99e-282	-	-	-	C	ko:K03300	-	ko00000	Citrate transporter
PIKALECD_02176	0.0	mcpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
PIKALECD_02177	3.75e-301	-	-	-	V	-	-	-	MatE
PIKALECD_02178	1.2e-50	-	-	-	-	-	-	-	-
PIKALECD_02179	2.69e-128	-	-	-	S	-	-	-	Tetratricopeptide repeat
PIKALECD_02180	2.89e-87	-	-	-	F	-	-	-	NUDIX domain
PIKALECD_02181	2.05e-143	-	-	-	-	-	-	-	-
PIKALECD_02183	8.5e-136	-	-	-	-	-	-	-	-
PIKALECD_02184	0.0	-	-	-	-	-	-	-	-
PIKALECD_02185	1.37e-67	-	-	-	-	-	-	-	-
PIKALECD_02186	1.03e-242	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	mannonate dehydratase activity
PIKALECD_02187	3.53e-230	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
PIKALECD_02188	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
PIKALECD_02189	2.8e-92	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
PIKALECD_02190	0.0	ycbD	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_02191	1.13e-218	ycbC	4.2.1.41	-	EM	ko:K01707	ko00053,ko01100,map00053,map01100	ko00000,ko00001,ko01000	5-dehydro-4-deoxyglucarate dehydratase activity
PIKALECD_02192	2.03e-154	ycbG	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
PIKALECD_02194	8.77e-110	-	-	-	K	-	-	-	Bacterial regulatory helix-turn-helix protein, lysR family
PIKALECD_02195	1.06e-164	citM	-	-	C	ko:K03300	-	ko00000	Citrate transporter
PIKALECD_02196	1.93e-186	-	-	-	C	-	-	-	Belongs to the LDH2 MDH2 oxidoreductase family
PIKALECD_02197	2.12e-59	-	-	-	G	-	-	-	myo-inosose-2 dehydratase activity
PIKALECD_02198	7.4e-91	-	-	-	M	-	-	-	racemase activity, acting on amino acids and derivatives
PIKALECD_02199	6.26e-140	kduD_2	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	KR domain
PIKALECD_02200	2.3e-195	-	-	-	C	ko:K19954	-	ko00000,ko01000	alcohol dehydrogenase
PIKALECD_02201	2.16e-238	gabD	-	-	C	-	-	-	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_02202	3.12e-123	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
PIKALECD_02210	1.4e-114	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
PIKALECD_02211	3.43e-13	-	-	-	-	-	-	-	-
PIKALECD_02212	0.0	tex	-	-	K	ko:K06959	-	ko00000	COG2183 Transcriptional accessory protein
PIKALECD_02213	9.86e-146	rsbX	3.1.3.3	-	KT	ko:K05518	-	ko00000,ko01000,ko03021	Sigma factor PP2C-like phosphatases
PIKALECD_02214	1.49e-180	sigB	-	-	K	ko:K03090	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PIKALECD_02215	6.56e-107	rsbW	2.7.11.1	-	T	ko:K04757	-	ko00000,ko01000,ko01001,ko03021	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
PIKALECD_02216	1.39e-70	rsbV	-	-	T	ko:K04749	-	ko00000,ko03021	Belongs to the anti-sigma-factor antagonist family
PIKALECD_02217	1.9e-233	rsbU	3.1.3.3	-	KT	ko:K07315	-	ko00000,ko01000,ko03021	phosphatase
PIKALECD_02218	5.84e-95	rsbT	2.7.11.1	-	T	ko:K17752	-	ko00000,ko01000,ko01001,ko03021	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
PIKALECD_02219	2.21e-69	rsbS	-	-	T	ko:K17762	-	ko00000,ko03021	antagonist
PIKALECD_02220	2.86e-179	rsbR	-	-	T	ko:K17763	-	ko00000,ko03021	Positive regulator of sigma-B
PIKALECD_02221	8.86e-74	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
PIKALECD_02222	4.38e-35	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
PIKALECD_02223	3.33e-284	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PIKALECD_02224	1.7e-237	ydcC	-	-	M	-	-	-	COG2834 Outer membrane lipoprotein-sorting protein
PIKALECD_02225	2.81e-76	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
PIKALECD_02226	6.53e-171	ydcA	-	-	S	-	-	-	membrane protein (homolog of Drosophila rhomboid)
PIKALECD_02227	3.34e-131	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PIKALECD_02228	0.0	yqgS	2.7.8.20	-	M	ko:K01138,ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
PIKALECD_02229	8.35e-177	yodJ	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
PIKALECD_02230	1.01e-62	-	-	-	-	-	-	-	-
PIKALECD_02231	8e-137	-	-	-	S	-	-	-	Integral membrane protein
PIKALECD_02232	1.27e-272	-	-	-	S	ko:K09927	-	ko00000	Winged helix DNA-binding domain
PIKALECD_02233	1.56e-175	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_02234	3.47e-244	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_02235	1.21e-246	-	-	-	G	-	-	-	Xylose isomerase
PIKALECD_02236	2.62e-201	-	-	-	S	-	-	-	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
PIKALECD_02237	2.2e-77	-	-	-	P	ko:K05571	-	ko00000,ko02000	COG1320 Multisubunit Na H antiporter, MnhG subunit
PIKALECD_02238	2.23e-51	mnhF2	-	-	P	ko:K05570	-	ko00000,ko02000	Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_02239	8.09e-111	mnhE2	-	-	P	ko:K05569	-	ko00000,ko02000	Na+/H+ ion antiporter subunit
PIKALECD_02240	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_02241	1.85e-66	mnhC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
PIKALECD_02242	5.43e-85	mnhB2	-	-	P	ko:K05566	-	ko00000,ko02000	antiporter activity
PIKALECD_02243	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
PIKALECD_02244	7.19e-167	-	-	-	T	-	-	-	Universal stress protein family
PIKALECD_02245	9.96e-141	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
PIKALECD_02246	9.78e-78	hxlR	-	-	K	-	-	-	transcriptional
PIKALECD_02247	1.89e-230	ykfD	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02248	3.2e-211	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
PIKALECD_02249	3.24e-221	ykfA	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
PIKALECD_02250	0.0	dppE	-	-	E	ko:K16199	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_02251	2.13e-231	dppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02252	2.02e-220	dppC	-	-	EP	ko:K16201	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02253	6.65e-207	dppB	-	-	P	ko:K16200	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02254	5.9e-193	dppA	-	-	E	ko:K16203	-	ko00000,ko01000,ko01002	D-aminopeptidase
PIKALECD_02255	1.95e-289	-	2.7.13.3	-	T	ko:K07706,ko:K07717	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase-like ATPases
PIKALECD_02256	1.98e-199	-	-	-	T	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	YcbB domain
PIKALECD_02257	2.46e-139	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_02258	4.65e-141	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_02259	3.82e-189	glnH	-	-	ET	ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
PIKALECD_02260	8.67e-170	glnQ	-	-	E	ko:K09972,ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
PIKALECD_02261	5.77e-194	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	-transporter
PIKALECD_02262	2.2e-253	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconolactonase
PIKALECD_02263	1.33e-06	gsiB	-	-	S	ko:K06884	-	ko00000	general stress protein
PIKALECD_02264	1.24e-198	-	2.1.1.184	-	J	ko:K00561	-	br01600,ko00000,ko01000,ko01504,ko03009	Ribosomal RNA adenine dimethylases
PIKALECD_02266	4.02e-71	-	-	-	S	-	-	-	Domain of unknown function (DUF4260)
PIKALECD_02267	3.12e-85	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_02268	2.67e-250	-	6.3.5.5	-	S	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	ATP-grasp domain
PIKALECD_02269	8.73e-261	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Peptidase dimerisation domain
PIKALECD_02270	1.29e-118	-	-	-	S	-	-	-	DinB superfamily
PIKALECD_02272	1.15e-163	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_02273	0.0	lacA	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	beta-galactosidase
PIKALECD_02274	1.81e-168	yvfO	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
PIKALECD_02275	1.31e-85	yvfO	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
PIKALECD_02276	2.65e-186	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
PIKALECD_02277	1.09e-307	malC	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
PIKALECD_02278	1.57e-298	cycB	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
PIKALECD_02279	2.06e-233	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02280	3.25e-193	yxxF	-	-	EG	-	-	-	EamA-like transporter family
PIKALECD_02281	1.69e-190	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02282	4.65e-129	-	-	-	S	-	-	-	ABC-2 family transporter protein
PIKALECD_02283	3.01e-192	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_02284	1.68e-228	ybfP	-	-	K	ko:K13653	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02285	9.66e-233	-	-	-	E	-	-	-	Amidinotransferase
PIKALECD_02286	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
PIKALECD_02287	5.19e-170	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
PIKALECD_02288	2.99e-239	-	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
PIKALECD_02289	2.08e-265	-	-	-	S	-	-	-	Erythromycin esterase
PIKALECD_02290	7.91e-115	ykuD	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02291	1.82e-217	-	-	-	S	-	-	-	Choline/ethanolamine kinase
PIKALECD_02292	1.69e-71	-	-	-	-	-	-	-	-
PIKALECD_02293	0.0	-	-	-	-	-	-	-	-
PIKALECD_02294	3.03e-119	-	-	-	-	-	-	-	-
PIKALECD_02295	8.58e-85	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02296	2.62e-38	-	-	-	-	-	-	-	-
PIKALECD_02299	0.0	-	-	-	-	-	-	-	-
PIKALECD_02300	4.61e-149	-	-	-	-	-	-	-	-
PIKALECD_02301	5.65e-206	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	COG1879 ABC-type sugar transport system, periplasmic component
PIKALECD_02302	2.68e-205	rbsC	-	-	G	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
PIKALECD_02303	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
PIKALECD_02304	1.28e-80	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
PIKALECD_02305	5.21e-197	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PIKALECD_02306	4.48e-231	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
PIKALECD_02308	6.06e-224	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Inosine-uridine preferring nucleoside hydrolase
PIKALECD_02310	5.03e-69	cas1	-	-	L	-	-	-	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_02311	3.84e-94	cas4	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	RecB family exonuclease
PIKALECD_02312	9.53e-144	csd2	-	-	L	ko:K19115,ko:K19118	-	ko00000,ko02048	CRISPR-associated protein
PIKALECD_02313	4.37e-232	csd1	-	-	M	ko:K19117	-	ko00000,ko02048	CRISPR-associated protein (Cas_Csd1)
PIKALECD_02314	3.69e-118	cas5	-	-	S	ko:K19119	-	ko00000,ko02048	CRISPR-associated protein
PIKALECD_02315	1.58e-270	-	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	Metal dependent phosphohydrolases with conserved 'HD' motif.
PIKALECD_02317	1.63e-90	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
PIKALECD_02318	2.03e-162	-	4.1.2.14	-	S	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	ko00000,ko00001,ko00002,ko01000	KDGP aldolase
PIKALECD_02319	8.62e-253	selA	2.9.1.1	-	E	ko:K01042	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko01000	L-seryl-tRNA selenium transferase
PIKALECD_02320	8.24e-146	-	-	-	S	-	-	-	Domain of unknown function (DUF4310)
PIKALECD_02321	9.36e-179	-	-	-	S	-	-	-	Domain of unknown function (DUF4311)
PIKALECD_02322	6.58e-75	-	-	-	S	-	-	-	Domain of unknown function (DUF4312)
PIKALECD_02323	1.55e-78	-	-	-	S	-	-	-	Glycine-rich SFCGS
PIKALECD_02324	3.97e-54	-	-	-	S	-	-	-	PRD domain
PIKALECD_02325	2.46e-272	-	3.5.2.3	-	S	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	amidohydrolase
PIKALECD_02326	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
PIKALECD_02327	0.0	-	-	-	G	-	-	-	alpha-L-rhamnosidase
PIKALECD_02328	0.0	lacZ	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	beta-galactosidase
PIKALECD_02329	1.71e-206	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_02330	0.0	-	-	-	L	-	-	-	Type III restriction enzyme res subunit
PIKALECD_02331	2.68e-309	pbpE	-	-	V	-	-	-	Beta-lactamase
PIKALECD_02332	1.07e-154	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_02333	1.23e-111	-	-	-	F	-	-	-	uridine kinase
PIKALECD_02334	6.89e-42	-	-	-	E	-	-	-	lactoylglutathione lyase activity
PIKALECD_02335	1.31e-73	yueD	1.1.1.320	-	IQ	ko:K16216	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_02336	1.3e-79	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_02337	2.96e-45	-	-	-	M	-	-	-	Host cell surface-exposed lipoprotein
PIKALECD_02338	5.39e-249	ybcL	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
PIKALECD_02339	1.18e-61	-	-	-	K	-	-	-	ArsR family transcriptional regulator
PIKALECD_02340	3.64e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF3533)
PIKALECD_02342	0.0	yobO	-	-	M	-	-	-	Pectate lyase superfamily protein
PIKALECD_02359	8.4e-183	yaaC	-	-	S	-	-	-	YaaC-like Protein
PIKALECD_02360	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
PIKALECD_02361	1.62e-304	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
PIKALECD_02362	9.06e-280	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PIKALECD_02363	1.58e-186	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
PIKALECD_02364	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
PIKALECD_02365	0.0	rocR	-	-	KT	ko:K06714	-	ko00000,ko03000	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
PIKALECD_02366	6.25e-288	rocD	2.6.1.13	-	E	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Catalyzes the interconversion of ornithine to glutamate semialdehyde
PIKALECD_02367	1.97e-239	rocG	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PIKALECD_02368	2.99e-307	nhaC_2	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
PIKALECD_02369	3.52e-297	-	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
PIKALECD_02370	6.52e-290	-	2.5.1.48, 4.4.1.11	-	E	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
PIKALECD_02371	1.03e-285	-	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_02372	1.72e-243	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
PIKALECD_02373	0.0	gabD_2	1.2.1.9	-	C	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_02374	7.34e-83	-	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
PIKALECD_02375	1.18e-184	glnH	-	-	ET	ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Ligated ion channel L-glutamate- and glycine-binding site
PIKALECD_02376	1.23e-141	glnP	-	-	E	ko:K02029,ko:K10037,ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Polar amino acid ABC transporter, inner membrane subunit
PIKALECD_02377	3.01e-165	-	3.6.3.21	-	E	ko:K02028,ko:K10038	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
PIKALECD_02378	1.11e-241	-	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02379	6.47e-245	-	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02380	3.19e-214	-	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02381	1.83e-203	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02382	0.0	gsiB_3	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_02384	6.95e-108	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
PIKALECD_02385	1.59e-130	clpP1	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
PIKALECD_02386	5.57e-142	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70, region 4
PIKALECD_02387	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PIKALECD_02388	4.53e-51	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PIKALECD_02389	9.21e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PIKALECD_02390	1.6e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
PIKALECD_02391	7.11e-29	bofA	-	-	S	ko:K06317	-	ko00000	Sigma-K factor-processing regulatory protein BofA
PIKALECD_02393	5.51e-54	-	-	-	-	-	-	-	-
PIKALECD_02394	1.33e-312	ywoF	-	-	P	-	-	-	Right handed beta helix region
PIKALECD_02395	2.2e-199	-	-	-	EG	-	-	-	EamA-like transporter family
PIKALECD_02397	1.85e-130	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_02398	2.7e-68	-	-	-	S	-	-	-	Family of unknown function (DUF5367)
PIKALECD_02399	3.92e-206	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02400	2.81e-233	phnT	3.6.3.30	-	P	ko:K02010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
PIKALECD_02401	5.55e-244	ftpB	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_02402	0.0	ftpA	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02403	2.78e-252	ysh1	-	-	J	-	-	-	Metallo-beta-lactamase superfamily
PIKALECD_02404	1.68e-183	M1-276	-	-	-	-	-	-	-
PIKALECD_02405	3.14e-164	-	-	-	S	-	-	-	KR domain
PIKALECD_02406	9.58e-112	-	-	-	-	-	-	-	-
PIKALECD_02407	0.0	-	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
PIKALECD_02409	4.5e-30	topA2	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Topoisomerase IA
PIKALECD_02410	1.78e-51	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
PIKALECD_02411	1.3e-14	mazE	-	-	T	ko:K07172	-	ko00000,ko02048	SpoVT / AbrB like domain
PIKALECD_02412	1.57e-14	-	-	-	Q	ko:K02614	ko00360,map00360	ko00000,ko00001,ko01000	Thioesterase superfamily
PIKALECD_02413	1.32e-224	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
PIKALECD_02414	2.77e-195	-	-	-	S	-	-	-	Tetratricopeptide repeat
PIKALECD_02415	6.23e-180	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
PIKALECD_02416	1.49e-290	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	COG2270 Permeases of the major facilitator superfamily
PIKALECD_02417	6.13e-258	cdaR_1	-	-	KT	ko:K02647	-	ko00000,ko03000	regulator
PIKALECD_02418	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
PIKALECD_02419	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
PIKALECD_02420	1.15e-198	ssuB	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
PIKALECD_02421	1.01e-133	ssuC_2	-	-	P	ko:K02050,ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02422	1.73e-221	ssuA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
PIKALECD_02423	1.57e-118	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_02424	2.25e-100	yybA	-	-	K	-	-	-	transcriptional
PIKALECD_02425	2.74e-119	-	-	-	S	-	-	-	VanZ like family
PIKALECD_02426	3.67e-123	bcrC	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Bacitracin ABC transporter permease
PIKALECD_02427	7.47e-234	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_02428	1.59e-11	-	-	-	-	-	-	-	-
PIKALECD_02429	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PIKALECD_02430	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PIKALECD_02431	9.83e-12	yqbO1	-	-	S	-	-	-	Domain of unknown function (DUF370)
PIKALECD_02432	4.47e-256	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PIKALECD_02433	1.15e-43	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain
PIKALECD_02434	3.45e-264	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
PIKALECD_02435	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PIKALECD_02436	3.58e-22	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
PIKALECD_02437	2.54e-72	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
PIKALECD_02438	3.04e-178	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
PIKALECD_02439	9.02e-141	jag	-	-	S	ko:K06346	-	ko00000	single-stranded nucleic acid binding R3H
PIKALECD_02440	1.99e-314	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PIKALECD_02441	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
PIKALECD_02442	7.14e-167	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
PIKALECD_02443	2.58e-192	noc	-	-	D	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
PIKALECD_02444	2.04e-174	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	COG1192 ATPases involved in chromosome partitioning
PIKALECD_02445	7.4e-195	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
PIKALECD_02446	4.44e-273	-	-	-	E	-	-	-	Aminotransferase class-V
PIKALECD_02447	6.65e-145	yyaC	-	-	S	-	-	-	Sporulation protein YyaC
PIKALECD_02448	1.18e-229	yyaD	-	-	S	-	-	-	Membrane
PIKALECD_02449	1.19e-37	yyzM	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02450	1.39e-246	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
PIKALECD_02451	3.39e-60	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
PIKALECD_02452	4.66e-89	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
PIKALECD_02453	4.32e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PIKALECD_02454	5.05e-187	yybS	-	-	S	-	-	-	membrane
PIKALECD_02455	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
PIKALECD_02456	1.41e-88	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
PIKALECD_02457	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
PIKALECD_02458	2.72e-315	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PIKALECD_02464	2.06e-170	yycF	-	-	T	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_02465	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_02466	4.27e-308	yycH	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02467	1.16e-207	yycI	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02468	1.83e-187	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
PIKALECD_02469	4.92e-268	yyxA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PIKALECD_02470	9.69e-104	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PIKALECD_02472	4.32e-70	-	-	-	L	ko:K07497	-	ko00000	COG2801 Transposase and inactivated derivatives
PIKALECD_02474	5.89e-156	-	-	-	K	-	-	-	SIR2-like domain
PIKALECD_02475	2.85e-62	-	-	-	S	-	-	-	MTH538 TIR-like domain (DUF1863)
PIKALECD_02476	3.27e-51	-	-	-	-	-	-	-	-
PIKALECD_02477	1.02e-43	-	-	-	S	-	-	-	TIR domain
PIKALECD_02478	1.66e-179	-	-	-	K	-	-	-	SIR2-like domain
PIKALECD_02479	1.14e-73	-	-	-	S	-	-	-	MTH538 TIR-like domain (DUF1863)
PIKALECD_02481	1e-90	-	-	-	Q	ko:K15256	-	ko00000,ko01000,ko03016	O-methyltransferase
PIKALECD_02482	4.67e-40	-	-	-	Q	ko:K15256	-	ko00000,ko01000,ko03016	O-methyltransferase
PIKALECD_02483	5.6e-171	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_02484	1.86e-203	-	-	-	-	-	-	-	-
PIKALECD_02485	2.36e-304	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
PIKALECD_02486	9.87e-141	-	-	-	K	-	-	-	FCD domain
PIKALECD_02487	6.66e-237	tdh	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
PIKALECD_02488	1.56e-232	-	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
PIKALECD_02489	2.49e-99	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_02490	5.94e-269	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
PIKALECD_02491	3.04e-156	-	-	-	G	-	-	-	Class II Aldolase and Adducin N-terminal domain
PIKALECD_02493	1.51e-112	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_02494	4.9e-112	-	-	-	S	-	-	-	Sulfite exporter TauE/SafE
PIKALECD_02495	5.96e-12	-	-	-	-	-	-	-	-
PIKALECD_02496	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
PIKALECD_02497	4.42e-222	appB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02498	2.08e-211	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_02499	7.36e-225	oppD3	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02500	4.28e-227	oppF3	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02501	1.15e-248	-	-	-	S	-	-	-	domain protein
PIKALECD_02502	0.0	ydfJ	-	-	S	ko:K07003	-	ko00000	MMPL family
PIKALECD_02503	1.31e-129	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02504	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_02505	8.01e-173	-	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
PIKALECD_02506	0.0	-	-	-	T	-	-	-	Carbon starvation protein
PIKALECD_02507	8.42e-102	-	-	-	-	-	-	-	-
PIKALECD_02508	9.43e-139	-	-	-	S	-	-	-	CGNR zinc finger
PIKALECD_02509	9.37e-96	-	-	-	S	-	-	-	Domain of unknown function (DU1801)
PIKALECD_02510	4.1e-214	-	-	-	S	-	-	-	Domain of unknown function (DUF4179)
PIKALECD_02511	5.43e-122	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
PIKALECD_02512	7.87e-111	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_02513	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
PIKALECD_02514	2.66e-246	yjmC	1.1.1.350	-	C	ko:K00073	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000	Belongs to the LDH2 MDH2 oxidoreductase family
PIKALECD_02515	5.63e-154	kdgR	-	-	K	-	-	-	FCD
PIKALECD_02516	1.19e-235	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_02517	1e-96	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_02518	2.43e-270	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
PIKALECD_02519	2.16e-244	citA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
PIKALECD_02520	2.81e-200	citR	-	-	K	ko:K19242	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02521	1.03e-235	-	-	-	S	ko:K07080	-	ko00000	NMT1-like family
PIKALECD_02522	0.0	-	-	-	S	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_02523	2.34e-151	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
PIKALECD_02524	2.28e-149	-	-	-	K	-	-	-	COG2186 Transcriptional regulators
PIKALECD_02525	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
PIKALECD_02526	1e-279	-	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
PIKALECD_02527	1.58e-284	lhgO	1.1.5.3	-	S	ko:K00111,ko:K15736	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	FAD dependent oxidoreductase
PIKALECD_02528	0.0	-	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
PIKALECD_02529	1.7e-282	codB	-	-	F	ko:K10974	-	ko00000,ko02000	cytosine purines uracil thiamine allantoin
PIKALECD_02530	2.35e-305	codA	3.5.4.1	-	F	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
PIKALECD_02532	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, N-terminal ig-like domain
PIKALECD_02533	2.26e-303	malE	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
PIKALECD_02534	2.9e-311	-	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
PIKALECD_02535	3.96e-190	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
PIKALECD_02536	3.72e-239	malR	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02537	5.15e-305	atoE	-	-	I	ko:K02106	ko02020,map02020	ko00000,ko00001	Short chain fatty acid transporter
PIKALECD_02538	6.11e-168	scoA	2.8.3.5	-	I	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PIKALECD_02539	8.72e-147	scoB	2.8.3.5	-	I	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
PIKALECD_02540	0.0	-	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182	ko00130,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the UbiD family
PIKALECD_02541	4.53e-239	mhqA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
PIKALECD_02543	4.46e-165	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
PIKALECD_02544	2.26e-288	yciC	-	-	S	-	-	-	GTPases (G3E family)
PIKALECD_02545	1.89e-52	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PIKALECD_02546	0.0	mutS1	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
PIKALECD_02547	3.96e-191	degV	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02548	8.13e-137	-	-	-	S	-	-	-	DUF218 domain
PIKALECD_02549	3.5e-70	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02550	7.15e-137	M1-1017	-	-	S	-	-	-	Protein of unknown function (DUF1129)
PIKALECD_02551	1.83e-10	-	-	-	-	-	-	-	-
PIKALECD_02552	6.66e-43	-	-	-	-	-	-	-	-
PIKALECD_02554	1.81e-239	-	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
PIKALECD_02555	8.67e-230	-	-	-	S	-	-	-	amine dehydrogenase activity
PIKALECD_02556	8e-154	-	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_02557	0.0	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_02558	1.38e-88	-	-	-	S	-	-	-	YtkA-like
PIKALECD_02559	8.59e-75	eaeH	-	-	M	ko:K13735	ko05100,map05100	ko00000,ko00001	LysM domain
PIKALECD_02560	2.2e-60	phhB	3.5.4.33, 4.2.1.96	-	H	ko:K01724,ko:K11991	ko00790,map00790	ko00000,ko00001,ko01000,ko03016,ko04147	pterin-4-alpha-carbinolamine dehydratase
PIKALECD_02561	2.62e-300	-	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
PIKALECD_02563	3.74e-169	ubiE	-	-	Q	-	-	-	Methyltransferase type 11
PIKALECD_02564	5.84e-126	-	-	-	S	ko:K09962	-	ko00000	protein conserved in bacteria
PIKALECD_02565	2.04e-276	-	-	-	EGP	-	-	-	Transmembrane secretion effector
PIKALECD_02566	4.62e-57	sdpI	-	-	S	-	-	-	integral membrane protein
PIKALECD_02569	2.43e-285	brnQ	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
PIKALECD_02570	7.81e-78	-	-	-	S	-	-	-	CHY zinc finger
PIKALECD_02571	7.83e-212	-	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
PIKALECD_02572	6.41e-148	M1-740	-	-	I	-	-	-	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
PIKALECD_02573	0.0	-	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
PIKALECD_02574	2.45e-163	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
PIKALECD_02575	0.0	sdcS	-	-	P	ko:K14445	-	ko00000,ko02000	Sodium:sulfate symporter transmembrane region
PIKALECD_02576	3.09e-139	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_02577	0.0	-	-	-	-	-	-	-	-
PIKALECD_02579	0.0	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_02581	1.13e-251	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PIKALECD_02582	3e-85	-	-	-	S	-	-	-	GNAT acetyltransferase
PIKALECD_02583	3.34e-83	-	-	-	-	-	-	-	-
PIKALECD_02584	4.84e-89	-	-	-	-	-	-	-	-
PIKALECD_02585	0.0	-	-	-	-	-	-	-	-
PIKALECD_02586	5.37e-122	-	-	-	-	-	-	-	-
PIKALECD_02587	2.2e-14	-	-	-	L	-	-	-	Bacterial transcription activator, effector binding domain
PIKALECD_02588	1.84e-72	yosT	-	-	L	-	-	-	Bacterial transcription activator, effector binding domain
PIKALECD_02589	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PIKALECD_02590	5.07e-130	-	-	-	K	-	-	-	GrpB protein
PIKALECD_02591	9.27e-219	-	-	-	O	-	-	-	Predicted Zn-dependent protease (DUF2268)
PIKALECD_02592	5.14e-170	-	-	-	K	-	-	-	TipAS antibiotic-recognition domain
PIKALECD_02594	1.62e-193	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PIKALECD_02595	7.63e-58	hxlR	-	-	K	-	-	-	HxlR-like helix-turn-helix
PIKALECD_02596	1.02e-123	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
PIKALECD_02597	1.28e-105	hxlB	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
PIKALECD_02598	2.95e-210	bmrU	-	-	I	-	-	-	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
PIKALECD_02599	4.8e-141	yrbG	-	-	S	-	-	-	membrane
PIKALECD_02600	2.61e-140	ywrF	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PIKALECD_02601	2.87e-217	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
PIKALECD_02602	0.0	ywjA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
PIKALECD_02603	0.0	katX	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
PIKALECD_02604	7.97e-121	-	-	-	S	-	-	-	DinB superfamily
PIKALECD_02605	2.27e-270	yxlH	-	-	EGP	-	-	-	Major Facilitator Superfamily
PIKALECD_02606	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PIKALECD_02607	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
PIKALECD_02608	1.46e-284	-	-	-	S	-	-	-	Acetyltransferase
PIKALECD_02609	0.0	dapE	-	-	E	-	-	-	Peptidase dimerisation domain
PIKALECD_02610	8.04e-187	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
PIKALECD_02611	1.8e-221	troA	-	-	P	ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
PIKALECD_02612	2.81e-180	mntB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K11710,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
PIKALECD_02613	3.27e-204	XK27_03890	-	-	P	ko:K11705,ko:K11708,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
PIKALECD_02614	7.92e-192	mntD	-	-	P	ko:K11709,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
PIKALECD_02615	8.32e-128	-	-	-	S	-	-	-	UPF0302 domain
PIKALECD_02616	2.09e-72	yflT	-	-	S	-	-	-	Heat induced stress protein YflT
PIKALECD_02617	4.66e-56	ydzA	-	-	EGP	-	-	-	Domain of unknown function (DUF3817)
PIKALECD_02618	2.34e-277	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
PIKALECD_02619	0.0	topB	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PIKALECD_02620	1.23e-311	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
PIKALECD_02621	7.64e-167	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
PIKALECD_02622	6.6e-241	yuaG	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	protein conserved in bacteria
PIKALECD_02623	3.41e-108	yuaF	-	-	OU	-	-	-	Membrane protein implicated in regulation of membrane protease activity
PIKALECD_02625	0.0	yhfW	-	-	CE	-	-	-	COG0665 Glycine D-amino acid oxidases (deaminating)
PIKALECD_02626	3.44e-91	bdbC	-	-	O	ko:K03611	-	ko00000,ko03110	Required for disulfide bond formation in some proteins
PIKALECD_02627	2.81e-101	bdbA	-	-	CO	-	-	-	Thioredoxin
PIKALECD_02628	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
PIKALECD_02629	3.78e-96	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_02630	1.72e-91	-	-	-	S	-	-	-	Protein of unknown function (DUF4064)
PIKALECD_02631	0.0	-	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	Glutamine synthetase, catalytic domain
PIKALECD_02632	1.21e-240	-	-	-	I	-	-	-	Fatty acid desaturase
PIKALECD_02633	6.59e-296	megL	4.4.1.11	-	E	ko:K01761	ko00270,ko00450,map00270,map00450	ko00000,ko00001,ko01000	methionine gamma-lyase
PIKALECD_02634	6.65e-146	XK27_07210	-	-	S	-	-	-	B3/4 domain
PIKALECD_02635	0.0	gntR9	-	-	K	-	-	-	Alanine-glyoxylate amino-transferase
PIKALECD_02636	5.74e-156	-	-	-	E	-	-	-	AzlC protein
PIKALECD_02637	8.36e-63	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
PIKALECD_02638	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Histidine ammonia-lyase
PIKALECD_02639	5.02e-188	pdxK	2.7.1.35, 2.7.1.49, 2.7.4.7	-	H	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
PIKALECD_02640	1.02e-303	-	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02641	2.23e-172	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PIKALECD_02642	1.16e-222	-	-	-	S	ko:K07120	-	ko00000	Pfam:AmoA
PIKALECD_02643	7.97e-294	nrgA	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium transporter
PIKALECD_02644	1.03e-212	-	-	-	T	ko:K07182	-	ko00000	Putative nucleotidyltransferase substrate binding domain
PIKALECD_02645	1.24e-170	polC1	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
PIKALECD_02646	1.47e-60	-	-	-	S	-	-	-	Family of unknown function (DUF5327)
PIKALECD_02647	0.0	putP	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PIKALECD_02648	1.58e-140	ykwB	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_02649	4.91e-78	ywdK	-	-	S	-	-	-	small membrane protein
PIKALECD_02650	5.01e-106	gerQ	-	-	S	ko:K06305	-	ko00000	Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
PIKALECD_02651	6.58e-101	cwlJ	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell wall
PIKALECD_02652	7.33e-163	-	-	-	-	-	-	-	-
PIKALECD_02653	9.31e-84	-	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
PIKALECD_02654	1.46e-207	natA1	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_02655	6.98e-210	yhaQ	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_02656	3.05e-245	yhaP	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	COG1668 ABC-type Na efflux pump, permease component
PIKALECD_02657	3.16e-64	-	-	-	-	-	-	-	-
PIKALECD_02658	5.82e-180	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
PIKALECD_02659	2.61e-184	ywfI	-	-	C	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko01000	May function as heme-dependent peroxidase
PIKALECD_02660	4.29e-180	-	5.3.3.18	-	I	ko:K15866	ko00360,ko01120,map00360,map01120	ko00000,ko00001,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
PIKALECD_02661	4.3e-231	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	In Salmonella this enzyme is required for ethanolamine catabolism
PIKALECD_02662	7.65e-185	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
PIKALECD_02663	9.03e-264	gltP	-	-	C	-	-	-	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
PIKALECD_02664	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	COG1078 HD superfamily phosphohydrolases
PIKALECD_02665	1.3e-115	ywgA	-	-	-	ko:K09388	-	ko00000	-
PIKALECD_02667	2.33e-55	cotF	-	-	M	ko:K06329	-	ko00000	Spore coat protein
PIKALECD_02668	6.92e-37	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	4-oxalocrotonate tautomerase
PIKALECD_02669	4.84e-160	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
PIKALECD_02670	1.14e-256	-	-	-	F	-	-	-	S-adenosylhomocysteine deaminase activity
PIKALECD_02671	3.38e-128	ywhD	-	-	S	-	-	-	YwhD family
PIKALECD_02672	0.0	-	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
PIKALECD_02673	1.15e-199	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_02674	0.0	pbpG	2.4.1.129, 3.4.16.4	GT51	M	ko:K21464	ko00550,map00550	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
PIKALECD_02675	2.08e-203	speE	2.5.1.16	-	E	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PIKALECD_02676	4.76e-213	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
PIKALECD_02677	1.05e-97	ywiB	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02678	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
PIKALECD_02679	1.8e-94	-	-	-	S	ko:K09793	-	ko00000	protein conserved in bacteria
PIKALECD_02680	1.67e-271	clsB	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the phospholipase D family. Cardiolipin synthase subfamily
PIKALECD_02681	0.0	ywjF	-	-	C	-	-	-	COG0247 Fe-S oxidoreductase
PIKALECD_02682	2.36e-269	mmgA	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
PIKALECD_02683	4.12e-193	mmgB	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	Dehydrogenase
PIKALECD_02684	7.79e-261	mmgC	-	-	I	ko:K18244	-	ko00000,ko01000	acyl-CoA dehydrogenase
PIKALECD_02685	3.55e-139	kstR2_2	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02686	1.26e-90	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
PIKALECD_02687	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
PIKALECD_02688	1.11e-113	ywjG	-	-	S	-	-	-	Domain of unknown function (DUF2529)
PIKALECD_02689	1.05e-77	spo0F	-	-	T	ko:K02490	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	response regulator
PIKALECD_02690	2.62e-203	fbaA	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Aldolase
PIKALECD_02691	8.05e-149	tal	2.2.1.2	-	G	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PIKALECD_02692	4.31e-280	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PIKALECD_02693	2.21e-228	glpX	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	fructose-1,6-bisphosphatase
PIKALECD_02694	2.94e-300	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PIKALECD_02695	2.08e-54	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
PIKALECD_02696	1.27e-140	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
PIKALECD_02697	1.69e-97	-	-	-	-	-	-	-	-
PIKALECD_02698	0.0	cdr	1.11.1.1	-	P	ko:K05910	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PIKALECD_02699	1.04e-230	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PIKALECD_02700	3.3e-202	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
PIKALECD_02701	9.49e-143	spoIIR	-	-	S	ko:K06387	-	ko00000	stage II sporulation protein R
PIKALECD_02702	1.3e-94	ywlB	1.20.4.1, 2.3.1.1	-	E	ko:K00537,ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetyltransferase family. ArgA subfamily
PIKALECD_02703	5.07e-230	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
PIKALECD_02704	2.59e-76	-	-	-	S	-	-	-	Regulator of ribonuclease activity B
PIKALECD_02705	1.61e-119	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
PIKALECD_02706	1.61e-92	ywlE	3.1.3.48, 3.9.1.2	-	T	ko:K01104,ko:K20201	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PIKALECD_02707	1.09e-179	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	Chemotaxis
PIKALECD_02708	1.59e-104	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase
PIKALECD_02709	1.43e-118	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
PIKALECD_02710	1.2e-299	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PIKALECD_02711	5.5e-148	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PIKALECD_02712	1.76e-114	panZ	-	-	K	-	-	-	-acetyltransferase
PIKALECD_02713	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
PIKALECD_02714	4.29e-40	-	-	-	S	-	-	-	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter
PIKALECD_02715	1.25e-10	atpI	-	-	S	ko:K02116	-	ko00000,ko00194	ATP synthase I chain
PIKALECD_02716	2.3e-168	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
PIKALECD_02717	2.78e-28	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PIKALECD_02718	2.37e-47	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PIKALECD_02719	2.37e-117	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PIKALECD_02720	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PIKALECD_02721	3.25e-193	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PIKALECD_02722	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PIKALECD_02723	2.09e-81	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
PIKALECD_02724	4.51e-21	ywmB	-	-	S	-	-	-	TATA-box binding
PIKALECD_02725	7.83e-301	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PIKALECD_02726	5.47e-237	spoIID	-	-	D	ko:K06381	-	ko00000	Stage II sporulation protein D
PIKALECD_02727	1.35e-168	spoIIQ	-	-	M	ko:K06386	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
PIKALECD_02728	8.46e-68	ykkC	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Multidrug resistance protein
PIKALECD_02729	1.6e-60	ykkD	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Multidrug resistance protein
PIKALECD_02730	1.68e-60	spoIIID	-	-	K	ko:K06283	-	ko00000,ko03000	Stage III sporulation protein D
PIKALECD_02731	1.9e-231	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein
PIKALECD_02732	1.13e-177	flhO	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
PIKALECD_02733	5.39e-179	flhP	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
PIKALECD_02734	1.05e-77	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
PIKALECD_02735	0.0	-	-	-	P	-	-	-	Spore gernimation protein GerA
PIKALECD_02736	1.81e-252	-	-	-	E	-	-	-	Spore germination protein
PIKALECD_02737	1.45e-238	-	-	-	S	ko:K06308	-	ko00000	Spore germination B3/ GerAC like, C-terminal
PIKALECD_02738	4.67e-139	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PIKALECD_02739	5.4e-174	estA	-	CE1	S	ko:K03930	-	ko00000,ko01000	Putative esterase
PIKALECD_02740	1.55e-94	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
PIKALECD_02741	0.0	pip	-	-	S	ko:K01421	-	ko00000	YhgE Pip N-terminal domain protein
PIKALECD_02742	2.48e-118	-	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
PIKALECD_02743	2.17e-102	yisT	-	-	S	-	-	-	DinB family
PIKALECD_02744	6.06e-20	-	-	-	Q	-	-	-	N-acetyltransferase
PIKALECD_02745	3.63e-289	lytE	-	-	M	-	-	-	NlpC/P60 family
PIKALECD_02746	5.12e-306	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PIKALECD_02747	3.1e-288	-	-	-	-	-	-	-	-
PIKALECD_02748	2.28e-58	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
PIKALECD_02749	2.22e-206	tagU	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
PIKALECD_02750	4.06e-244	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
PIKALECD_02751	1.77e-281	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
PIKALECD_02752	7.25e-102	-	-	-	G	-	-	-	Transmembrane secretion effector
PIKALECD_02753	2.13e-101	guaD	3.5.4.3	-	FJ	ko:K01487	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	COG0590 Cytosine adenosine deaminases
PIKALECD_02754	7.21e-65	-	-	-	E	-	-	-	LysE type translocator
PIKALECD_02755	7.32e-105	-	-	-	S	-	-	-	Tetratrico peptide repeat
PIKALECD_02756	1.42e-217	tagU	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
PIKALECD_02757	1.78e-149	ywqC	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
PIKALECD_02758	6.06e-156	epsB	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
PIKALECD_02759	4.31e-182	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	COG4464 Capsular polysaccharide biosynthesis protein
PIKALECD_02760	7.53e-94	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
PIKALECD_02761	3.64e-178	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
PIKALECD_02762	4.65e-195	-	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PIKALECD_02763	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_02764	0.0	-	-	-	T	-	-	-	Domain present in phytochromes and cGMP-specific phosphodiesterases.
PIKALECD_02765	7.21e-226	-	-	-	S	-	-	-	Tetratricopeptide repeat
PIKALECD_02768	3.41e-205	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_02769	5.61e-29	ywnB	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
PIKALECD_02770	1.57e-83	-	-	-	F	-	-	-	PFAM AIG2 family protein
PIKALECD_02771	0.0	-	-	-	E	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PIKALECD_02772	6.58e-293	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
PIKALECD_02774	0.0	hydA	3.5.2.2	-	F	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Amidohydrolase family
PIKALECD_02775	3.54e-295	preA	1.3.1.1	-	CF	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	dihydroorotate dehydrogenase
PIKALECD_02776	9.28e-317	gltD	1.3.1.1	-	E	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
PIKALECD_02777	3.12e-77	-	-	-	K	-	-	-	DeoR C terminal sensor domain
PIKALECD_02778	5.27e-170	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
PIKALECD_02779	2.21e-63	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
PIKALECD_02780	3.1e-45	-	-	-	G	-	-	-	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_02781	3.25e-190	-	-	-	G	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase system, EIIC
PIKALECD_02782	6e-95	-	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Pfam:DUF1498
PIKALECD_02783	5.32e-153	-	-	-	G	-	-	-	Dak1 domain
PIKALECD_02784	9.4e-67	-	-	-	G	-	-	-	Ribose/Galactose Isomerase
PIKALECD_02785	2.88e-63	-	-	-	G	-	-	-	Ribose/Galactose Isomerase
PIKALECD_02786	1.94e-95	-	5.3.1.1	-	J	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Triosephosphate isomerase
PIKALECD_02787	4.29e-101	-	-	-	-	-	-	-	-
PIKALECD_02789	2.12e-27	tnpB	-	-	L	-	-	-	Belongs to the 'phage' integrase family
PIKALECD_02790	6.11e-27	-	-	-	-	-	-	-	-
PIKALECD_02791	1.46e-117	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_02792	4.68e-158	-	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
PIKALECD_02793	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PIKALECD_02794	3.28e-175	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_02795	8.46e-205	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02796	2.66e-220	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02797	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_02798	1.56e-172	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
PIKALECD_02799	2.89e-228	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
PIKALECD_02800	3.73e-266	ycsG	-	-	P	-	-	-	COG1914 Mn2 and Fe2 transporters of the NRAMP family
PIKALECD_02801	2.28e-171	ycsF	-	-	S	ko:K07160	-	ko00000	Belongs to the UPF0271 (lamB) family
PIKALECD_02802	4.6e-12	-	-	-	-	-	-	-	-
PIKALECD_02803	3.85e-142	-	-	-	P	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
PIKALECD_02804	3.91e-74	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_02805	4.87e-148	ydgI	-	-	C	-	-	-	nitroreductase
PIKALECD_02806	1.84e-218	scrR	-	-	K	ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
PIKALECD_02807	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
PIKALECD_02808	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_02809	5.45e-312	hemAT	-	-	NT	ko:K06595	-	ko00000,ko02035	chemotaxis protein
PIKALECD_02810	2.42e-169	-	-	-	S	-	-	-	Nucleotidyltransferase domain
PIKALECD_02811	9.07e-196	-	3.5.2.6	-	V	ko:K17838	ko01501,map01501	ko00000,ko00001,ko01000	beta-lactamase
PIKALECD_02812	1.32e-153	-	-	-	KT	-	-	-	Forkhead associated domain
PIKALECD_02813	4.94e-304	amaB_2	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
PIKALECD_02814	3.08e-204	yuiI	-	-	S	ko:K07017	-	ko00000	Putative esterase
PIKALECD_02815	4.33e-236	feuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_02816	2.06e-235	feuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_02817	9.27e-223	feuA	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Iron-uptake system-binding protein
PIKALECD_02818	0.0	ybbB	-	-	K	ko:K21701	-	ko00000,ko03000	COG2207 AraC-type DNA-binding domain-containing proteins
PIKALECD_02819	4.83e-102	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02820	1.52e-160	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_02821	7.82e-59	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_02822	6.69e-225	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
PIKALECD_02823	3.97e-226	ectD	1.14.11.55	-	Q	ko:K10674	ko00260,ko01120,map00260,map01120	ko00000,ko00001,ko01000	Phytanoyl-CoA dioxygenase (PhyH)
PIKALECD_02824	1.23e-198	-	-	-	-	-	-	-	-
PIKALECD_02825	5e-11	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
PIKALECD_02826	4.07e-241	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
PIKALECD_02827	3.89e-228	gerKB	-	-	E	-	-	-	Spore germination protein
PIKALECD_02828	4.13e-239	gerKC	-	-	S	-	-	-	Spore germination B3/ GerAC like, C-terminal
PIKALECD_02829	0.0	bceB	-	-	V	ko:K11632,ko:K19080	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter (permease)
PIKALECD_02830	1.38e-171	bceA	-	-	V	ko:K02003,ko:K11631,ko:K19079	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter, ATP-binding protein
PIKALECD_02831	0.0	-	-	-	S	-	-	-	Chlorophyllase enzyme
PIKALECD_02832	2.22e-82	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_02833	0.0	-	-	-	GKT	-	-	-	Mga helix-turn-helix domain
PIKALECD_02834	4.89e-218	-	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
PIKALECD_02835	1.07e-58	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
PIKALECD_02836	8.15e-270	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
PIKALECD_02837	1.5e-196	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
PIKALECD_02838	9.69e-57	mviM3	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_02839	6.74e-135	mviM3	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_02840	3.48e-40	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
PIKALECD_02841	1.91e-98	ydeB	-	-	K	ko:K07736	-	ko00000,ko03000	Transcription factor
PIKALECD_02842	2.26e-65	arsR	-	-	K	ko:K03892	-	ko00000,ko03000	ArsR family transcriptional regulator
PIKALECD_02843	5.33e-86	cadI	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_02844	9.94e-71	arsR	-	-	K	ko:K03892,ko:K22043	-	ko00000,ko03000	transcriptional
PIKALECD_02845	3.96e-278	ydfA	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PIKALECD_02846	9.45e-99	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Catalyzes the reduction of arsenate As(V) to arsenite As(III)
PIKALECD_02848	5.33e-294	oxdD	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
PIKALECD_02849	6.33e-207	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
PIKALECD_02851	3.63e-143	ydhC	-	-	K	-	-	-	FCD
PIKALECD_02852	4.62e-252	ycsA	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Tartrate dehydrogenase
PIKALECD_02853	2.8e-85	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_02854	2.75e-154	-	-	-	C	-	-	-	Oxidoreductase NAD-binding domain
PIKALECD_02855	0.0	-	-	-	L	-	-	-	ABC transporter
PIKALECD_02856	1.54e-96	-	-	-	K	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
PIKALECD_02857	1.05e-74	-	-	-	K	ko:K03892	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
PIKALECD_02858	4.23e-87	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
PIKALECD_02859	8.09e-65	azlD	-	-	E	-	-	-	Branched-chain amino acid transport protein (AzlD)
PIKALECD_02860	1.95e-160	azlC	-	-	E	-	-	-	AzlC protein
PIKALECD_02861	3.12e-95	-	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
PIKALECD_02862	4.61e-93	-	-	-	S	ko:K04750	-	ko00000	3-demethylubiquinone-9 3-methyltransferase
PIKALECD_02863	1.11e-59	-	-	-	GM	-	-	-	NmrA-like family
PIKALECD_02864	3.51e-290	-	-	-	F	-	-	-	Belongs to the Nudix hydrolase family
PIKALECD_02865	7.09e-88	-	-	-	J	-	-	-	L-PSP family endoribonuclease
PIKALECD_02866	6.61e-196	-	-	-	S	-	-	-	Phenazine biosynthesis-like protein
PIKALECD_02867	0.0	-	-	-	K	ko:K03491	-	ko00000,ko03000	transcriptional regulator, MtlR
PIKALECD_02868	7.2e-202	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
PIKALECD_02869	0.0	-	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
PIKALECD_02870	1.3e-206	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
PIKALECD_02871	2.58e-126	-	-	-	-	-	-	-	-
PIKALECD_02873	5.17e-36	-	-	-	-	-	-	-	-
PIKALECD_02878	4.92e-207	-	-	-	E	ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycine betaine ABC transporter
PIKALECD_02879	0.0	-	-	-	S	-	-	-	Predicted membrane protein (DUF2254)
PIKALECD_02880	8.3e-223	-	-	-	P	ko:K07217	-	ko00000	Catalase
PIKALECD_02883	1.35e-89	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_02885	9.97e-41	-	-	-	-	-	-	-	-
PIKALECD_02886	1e-215	yflN	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
PIKALECD_02887	3.29e-282	fdh	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
PIKALECD_02888	2.54e-10	-	-	-	-	-	-	-	-
PIKALECD_02889	1.45e-180	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
PIKALECD_02890	4.35e-143	-	-	-	Q	-	-	-	Methyltransferase domain
PIKALECD_02891	8.89e-80	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
PIKALECD_02892	7.26e-208	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
PIKALECD_02893	4.25e-160	-	-	-	-	-	-	-	-
PIKALECD_02894	1.61e-194	yerO	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_02896	0.0	swrC	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PIKALECD_02897	3.08e-39	-	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
PIKALECD_02898	1.03e-37	-	-	-	S	-	-	-	spore protein
PIKALECD_02899	4.47e-155	-	-	-	S	-	-	-	membrane
PIKALECD_02900	2.44e-112	ypmQ	-	-	S	ko:K07152	-	ko00000,ko03029	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
PIKALECD_02901	0.0	gdhA	1.4.1.2, 1.4.1.4	-	E	ko:K00260,ko:K00262	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
PIKALECD_02902	5.54e-212	gltC	-	-	K	ko:K09681	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_02903	4.85e-65	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	transcriptional
PIKALECD_02904	1.43e-201	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	COG1230 Co Zn Cd efflux system component
PIKALECD_02905	5.86e-195	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PIKALECD_02906	3.18e-141	-	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PIKALECD_02907	4.03e-215	-	-	-	K	-	-	-	WYL domain
PIKALECD_02908	2.86e-215	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_02909	0.0	-	-	-	C	-	-	-	FAD dependent oxidoreductase
PIKALECD_02910	5.43e-191	ugpE3	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02911	1.66e-217	-	-	-	U	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02912	8.27e-311	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_02913	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_02914	5e-173	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
PIKALECD_02915	0.0	-	-	-	G	-	-	-	beta-fructofuranosidase activity
PIKALECD_02917	2.19e-61	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_02918	2.77e-249	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_02919	1.13e-152	cas4	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	RecB family exonuclease
PIKALECD_02920	1.3e-202	csd2	-	-	L	ko:K19115,ko:K19118	-	ko00000,ko02048	CRISPR-associated protein Cas7
PIKALECD_02921	0.0	csd1	-	-	M	ko:K19117	-	ko00000,ko02048	CRISPR-associated protein (Cas_Csd1)
PIKALECD_02922	1.76e-171	cas5	-	-	S	ko:K19119	-	ko00000,ko02048	CRISPR-associated protein (Cas_Cas5)
PIKALECD_02923	0.0	-	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	Metal dependent phosphohydrolases with conserved 'HD' motif.
PIKALECD_02925	1.5e-158	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
PIKALECD_02926	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
PIKALECD_02927	6.38e-96	-	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
PIKALECD_02928	5.12e-302	-	-	-	G	-	-	-	Protein of unknown function (DUF4038)
PIKALECD_02929	2.3e-283	-	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_02930	0.0	glpK3	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	FGGY family of carbohydrate kinases, C-terminal domain
PIKALECD_02931	1.4e-213	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
PIKALECD_02932	1.23e-191	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	COG3959 Transketolase, N-terminal subunit
PIKALECD_02933	0.0	-	-	-	G	-	-	-	isomerase
PIKALECD_02934	5.23e-218	-	-	-	K	ko:K02529	-	ko00000,ko03000	Bacterial regulatory proteins, lacI family
PIKALECD_02935	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
PIKALECD_02937	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PIKALECD_02938	1.9e-277	ybbR	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_02939	3.79e-185	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PIKALECD_02940	2.31e-155	rsiW	-	-	K	-	-	-	Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
PIKALECD_02941	5.59e-128	sigW	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
PIKALECD_02948	3.99e-12	-	-	-	-	-	-	-	-
PIKALECD_02950	1.22e-09	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
PIKALECD_02951	0.0	gsiB_3	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_02952	2.52e-139	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
PIKALECD_02953	6.04e-71	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_02955	5.98e-312	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
PIKALECD_02956	2.26e-181	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_02957	2.07e-170	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
PIKALECD_02958	6.6e-179	-	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02959	3.51e-191	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_02960	3.49e-169	-	3.4.17.11	-	E	ko:K01295	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_02962	0.0	yvcC1	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
PIKALECD_02963	1.18e-221	XK27_06795	-	-	K	ko:K20391	ko02024,map02024	ko00000,ko00001,ko03000	sequence-specific DNA binding
PIKALECD_02965	0.0	bsaB	-	-	S	ko:K20483	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lantibiotic dehydratase, C terminus
PIKALECD_02966	0.0	spaC1	-	-	V	ko:K20484	ko02020,ko02024,map02020,map02024	ko00000,ko00001	Lanthionine synthetase C-like protein
PIKALECD_02967	3.1e-131	-	-	-	H	-	-	-	Flavoprotein
PIKALECD_02968	8.87e-158	pstB13	-	-	V	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
PIKALECD_02969	3.04e-159	-	-	-	S	-	-	-	ABC-2 family transporter protein
PIKALECD_02970	1.51e-161	-	-	-	-	-	-	-	-
PIKALECD_02971	1.24e-156	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
PIKALECD_02972	0.0	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
PIKALECD_02973	1.46e-80	-	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Helix-hairpin-helix motif
PIKALECD_02974	1.55e-290	-	-	-	E	-	-	-	Peptidase dimerisation domain
PIKALECD_02975	7.15e-75	-	-	-	S	ko:K09940	-	ko00000	Domain of unknown function (DUF4870)
PIKALECD_02976	1.01e-273	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
PIKALECD_02977	5.2e-139	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
PIKALECD_02978	1.07e-212	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
PIKALECD_02979	1.13e-141	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
PIKALECD_02980	4.57e-51	crh	-	-	G	ko:K11184	-	ko00000	Phosphocarrier protein Chr
PIKALECD_02981	1.97e-228	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
PIKALECD_02982	3e-225	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
PIKALECD_02983	4.57e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
PIKALECD_02984	2.13e-116	yvcI	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	Nudix hydrolase
PIKALECD_02985	8.31e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
PIKALECD_02986	4.42e-249	yvcD	-	-	S	-	-	-	COG0457 FOG TPR repeat
PIKALECD_02987	2.94e-166	cypC	1.11.2.4	-	Q	ko:K15629	-	ko00000,ko00199,ko01000	Cytochrome P450
PIKALECD_02988	2.52e-115	ydeD	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
PIKALECD_02989	5.89e-53	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_02990	8.46e-161	-	-	-	K	-	-	-	FR47-like protein
PIKALECD_02991	1.35e-142	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the PRA-CH family
PIKALECD_02992	3.13e-173	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
PIKALECD_02993	3.01e-165	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PIKALECD_02994	5.51e-147	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PIKALECD_02995	3.1e-138	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
PIKALECD_02996	1.22e-289	hisD	1.1.1.23, 1.1.1.308	-	E	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PIKALECD_02997	3.41e-144	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
PIKALECD_02998	3.53e-275	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PIKALECD_02999	1.36e-243	bdhA	1.1.1.264, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00098	ko00650,map00650	ko00000,ko00001,ko01000	Dehydrogenase
PIKALECD_03000	9.07e-13	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03001	6.41e-28	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03002	2.13e-96	-	-	-	-	-	-	-	-
PIKALECD_03003	1.51e-34	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
PIKALECD_03004	2.81e-74	yqjZ	-	-	S	-	-	-	enzyme involved in biosynthesis of extracellular polysaccharides
PIKALECD_03005	8.76e-67	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
PIKALECD_03006	1.24e-148	-	-	-	S	-	-	-	Protein of unknown function (DUF2812)
PIKALECD_03007	1.94e-244	-	-	-	EGP	-	-	-	MFS/sugar transport protein
PIKALECD_03008	5.16e-174	-	-	-	KT	-	-	-	Transcriptional regulator containing PAS AAA-type ATPase and DNA-binding
PIKALECD_03009	2.78e-241	-	-	-	M	-	-	-	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain
PIKALECD_03010	9.48e-204	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
PIKALECD_03011	1.82e-183	-	-	-	K	-	-	-	MerR family transcriptional regulator
PIKALECD_03012	5.18e-94	-	-	-	-	-	-	-	-
PIKALECD_03013	4.39e-149	-	-	-	O	-	-	-	Sap, sulfolipid-1-addressing protein
PIKALECD_03014	1.96e-110	-	2.7.1.190	-	S	ko:K17910	-	ko00000,ko01000,ko01504	Protein of unknown function (DUF1679)
PIKALECD_03017	7.21e-101	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_03018	8.34e-221	-	-	-	L	-	-	-	Endonuclease/Exonuclease/phosphatase family
PIKALECD_03021	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
PIKALECD_03022	8.21e-215	iolE	4.2.1.44	-	G	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
PIKALECD_03023	2.43e-240	iolG	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
PIKALECD_03024	8.26e-126	iolI	5.3.99.11	-	G	ko:K06606	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
PIKALECD_03025	7.4e-197	iolJ	4.1.2.13, 4.1.2.29	-	F	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
PIKALECD_03026	1.75e-230	-	1.1.1.18, 1.1.1.369, 1.1.1.370	-	S	ko:K00010,ko:K16043	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_03027	0.0	-	-	-	S	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PIKALECD_03028	1.47e-175	iolH	-	-	G	ko:K06605	-	ko00000	Xylose isomerase-like TIM barrel
PIKALECD_03029	8.49e-194	iolT	-	-	U	ko:K02100,ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
PIKALECD_03030	1.66e-305	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	O-acetylhomoserine
PIKALECD_03031	2.95e-77	-	-	-	S	ko:K06940	-	ko00000	Putative zinc- or iron-chelating domain
PIKALECD_03032	7.02e-182	-	-	-	G	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03033	3.71e-209	-	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03034	7.51e-154	-	-	-	J	-	-	-	translation release factor activity
PIKALECD_03035	1.71e-91	ohrB	-	-	O	-	-	-	Organic hydroperoxide resistance protein
PIKALECD_03036	2.04e-293	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	phosphorylase
PIKALECD_03037	1.65e-285	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PIKALECD_03038	1.21e-213	xerD	-	-	L	ko:K04763	-	ko00000,ko03036	recombinase XerD
PIKALECD_03039	8.77e-19	-	-	-	S	-	-	-	Protein of unknown function (DUF4227)
PIKALECD_03040	8.92e-111	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
PIKALECD_03041	6.83e-140	spoIIM	-	-	S	ko:K06384	-	ko00000	Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
PIKALECD_03042	2.38e-116	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
PIKALECD_03044	1.6e-106	-	-	-	CO	-	-	-	Thioredoxin-like
PIKALECD_03045	1.47e-179	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
PIKALECD_03046	9.59e-268	mtnW	5.3.2.5	-	G	ko:K08965	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
PIKALECD_03047	1.04e-118	-	-	-	S	-	-	-	UPF0316 protein
PIKALECD_03048	6.73e-107	ypqE	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
PIKALECD_03049	6.04e-73	ygzB	-	-	S	-	-	-	UPF0295 protein
PIKALECD_03050	1.18e-103	perR	-	-	P	ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
PIKALECD_03051	6.47e-64	-	-	-	S	-	-	-	Cyclic-di-AMP receptor
PIKALECD_03052	2.67e-222	ghrA	-	-	EH	-	-	-	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PIKALECD_03053	7.75e-113	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Peroxiredoxin
PIKALECD_03054	2.67e-309	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
PIKALECD_03055	1.04e-234	ygaE	-	-	S	-	-	-	Membrane
PIKALECD_03056	0.0	ygaD	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
PIKALECD_03057	2.94e-133	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
PIKALECD_03058	1.43e-21	-	-	-	S	ko:K06422	-	ko00000	Small, acid-soluble spore protein, gamma-type
PIKALECD_03059	9.29e-169	fabL	1.3.1.104	-	IQ	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03060	5.62e-27	yfhS	-	-	-	-	-	-	-
PIKALECD_03061	2.23e-77	-	-	-	-	-	-	-	-
PIKALECD_03062	4.73e-162	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03063	5.47e-257	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific
PIKALECD_03064	2.33e-237	yfhP	-	-	S	ko:K07038	-	ko00000	membrane-bound metal-dependent
PIKALECD_03065	9.25e-30	-	-	-	S	-	-	-	YpzG-like protein
PIKALECD_03066	2.96e-66	yfhH	-	-	S	-	-	-	Protein of unknown function (DUF1811)
PIKALECD_03067	1.03e-177	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
PIKALECD_03068	6.23e-213	yfhF	-	-	S	ko:K07071	-	ko00000	nucleoside-diphosphate sugar epimerase
PIKALECD_03069	1.36e-65	-	-	-	-	-	-	-	-
PIKALECD_03070	1.38e-84	mccF	-	-	V	-	-	-	LD-carboxypeptidase
PIKALECD_03071	1.21e-114	mccF	-	-	V	-	-	-	LD-carboxypeptidase
PIKALECD_03072	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PIKALECD_03073	2.29e-81	-	-	-	-	-	-	-	-
PIKALECD_03074	3.19e-173	-	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
PIKALECD_03075	1.32e-234	-	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03076	3.09e-174	-	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03077	2.96e-146	surE	3.1.3.5	-	S	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Survival protein SurE
PIKALECD_03078	1.61e-107	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_03079	8e-206	-	-	-	O	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
PIKALECD_03080	0.0	thiC	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PIKALECD_03082	5.27e-189	pdaA	-	-	G	ko:K01567	-	ko00000,ko01000	deacetylase
PIKALECD_03083	1.86e-180	-	-	-	S	ko:K08974	-	ko00000	Domain of unknown function (DUF368)
PIKALECD_03084	1.83e-313	-	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
PIKALECD_03085	1.02e-146	-	-	-	G	ko:K15640	-	ko00000	Belongs to the phosphoglycerate mutase family
PIKALECD_03086	8e-278	yfkA	-	-	S	-	-	-	YfkB-like domain
PIKALECD_03087	3.98e-188	yfkD	-	-	S	-	-	-	YfkD-like protein
PIKALECD_03090	1.21e-29	-	-	-	S	-	-	-	Fur-regulated basic protein B
PIKALECD_03091	4.16e-314	ythA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
PIKALECD_03092	9.49e-240	ythB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
PIKALECD_03093	6.61e-166	-	-	-	-	-	-	-	-
PIKALECD_03094	0.0	pepF2	-	-	E	-	-	-	COG1164 Oligoendopeptidase F
PIKALECD_03095	0.0	kat	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
PIKALECD_03096	9.99e-305	-	1.14.13.59	-	Q	ko:K03897	ko00310,ko01120,map00310,map01120	ko00000,ko00001,ko01000	L-lysine 6-monooxygenase (NADPH-requiring)
PIKALECD_03097	0.0	ywdH	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
PIKALECD_03098	6.75e-144	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Caulimovirus viroplasmin
PIKALECD_03099	1.81e-54	-	-	-	-	-	-	-	-
PIKALECD_03100	5.13e-61	-	-	-	K	-	-	-	SpoVT / AbrB like domain
PIKALECD_03101	2.07e-75	-	-	-	-	-	-	-	-
PIKALECD_03102	1.91e-299	yhdH	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
PIKALECD_03103	2.05e-231	mreBH	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod-share determining protein MreBH
PIKALECD_03104	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
PIKALECD_03105	1.84e-208	pfkB	2.7.1.56	-	G	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
PIKALECD_03106	1.17e-169	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_03107	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
PIKALECD_03108	7.22e-262	nos	1.14.14.47	-	C	ko:K00491	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PIKALECD_03109	3.12e-110	bsaA	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
PIKALECD_03110	2.57e-160	treR	-	-	K	ko:K03486	-	ko00000,ko03000	transcriptional
PIKALECD_03111	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
PIKALECD_03112	0.0	treP	2.7.1.201	-	G	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_03113	0.0	ggt	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
PIKALECD_03114	0.0	yngK	-	-	T	-	-	-	Glycosyl hydrolase-like 10
PIKALECD_03115	3.85e-298	ykvU	-	-	S	-	-	-	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
PIKALECD_03116	1.87e-305	alsT	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
PIKALECD_03117	2.79e-120	glpP	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PIKALECD_03118	0.0	glpD	1.1.5.3	-	C	ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PIKALECD_03119	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PIKALECD_03120	1.01e-292	kinB3	2.7.13.3	-	T	ko:K07697	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_03121	0.0	yfiC3	-	-	V	ko:K06147	-	ko00000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_03122	0.0	yfiB3	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
PIKALECD_03123	0.0	uvrD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
PIKALECD_03124	2.01e-215	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter
PIKALECD_03125	1.8e-179	phnC	3.6.3.28	-	P	ko:K02041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PIKALECD_03126	3.49e-175	phnE	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_03127	2.12e-183	ptxC	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_03128	4.56e-175	-	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PIKALECD_03129	7.83e-301	-	-	-	V	-	-	-	MatE
PIKALECD_03130	8.48e-132	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_03131	1.27e-81	gpm5	3.1.3.3, 5.4.2.11	-	G	ko:K01834,ko:K22305	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	alpha-ribazole phosphatase activity
PIKALECD_03132	7.81e-201	pepI	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Alpha/beta hydrolase family
PIKALECD_03133	3.84e-204	dppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_03134	1.14e-232	dppB	-	-	EP	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
PIKALECD_03135	0.0	hbpA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_03136	6.16e-236	appF	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03137	2.22e-232	dppD	-	-	P	ko:K02031,ko:K16202	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03138	0.0	XK27_11280	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
PIKALECD_03139	7.45e-74	-	-	-	S	-	-	-	Domain of unknown function (DUF4440)
PIKALECD_03140	6.16e-131	ynaD	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03141	1.23e-291	-	-	-	S	ko:K07112	-	ko00000	Sulphur transport
PIKALECD_03142	3.35e-222	-	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	transport system, periplasmic component
PIKALECD_03143	5.7e-218	-	-	-	S	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
PIKALECD_03144	1.6e-177	-	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	transport system, ATPase component
PIKALECD_03145	6.23e-238	-	-	-	-	-	-	-	-
PIKALECD_03146	8.03e-256	cysA	3.6.3.25	-	P	ko:K02045	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PIKALECD_03147	3.93e-171	cysW	-	-	P	ko:K02047	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG4208 ABC-type sulfate transport system, permease component
PIKALECD_03148	7.2e-174	cysT	-	-	O	ko:K02046	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0555 ABC-type sulfate transport system, permease component
PIKALECD_03149	5.54e-243	sbp	-	-	P	ko:K02048	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG1613 ABC-type sulfate transport system, periplasmic component
PIKALECD_03150	4.45e-104	ebsC	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PIKALECD_03151	0.0	-	-	-	T	-	-	-	COG0642 Signal transduction histidine kinase
PIKALECD_03152	0.0	dld	1.1.2.4, 1.1.3.15	-	C	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
PIKALECD_03153	2.07e-199	yocS	-	-	S	ko:K03453	-	ko00000	-transporter
PIKALECD_03154	6.69e-300	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
PIKALECD_03155	1.04e-91	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_03156	1.96e-83	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_03157	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
PIKALECD_03158	8.15e-267	ytpB	4.2.3.130	-	S	ko:K16188	-	ko00000,ko01000	Tetraprenyl-beta-curcumene synthase
PIKALECD_03159	9.94e-90	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_03160	6.15e-127	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_03161	7e-196	malG	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03162	2.72e-222	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03163	0.0	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03164	0.0	-	-	-	S	ko:K09955	-	ko00000	Beta-L-arabinofuranosidase, GH127
PIKALECD_03165	1.17e-216	yisR1	3.2.1.23	-	K	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	AraC-like ligand binding domain
PIKALECD_03166	7.68e-160	spaF	-	-	V	ko:K01990,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03167	4.6e-170	spaE	-	-	S	ko:K20491	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
PIKALECD_03168	5.84e-174	spaG	-	-	S	ko:K20492	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
PIKALECD_03169	4.88e-161	spaR	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
PIKALECD_03170	0.0	spaK	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
PIKALECD_03171	3.84e-94	-	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PIKALECD_03172	1.05e-97	lrpC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	helix_turn_helix ASNC type
PIKALECD_03173	4.59e-133	argO	-	-	S	ko:K06895	-	ko00000,ko02000	Lysine exporter protein LysE YggA
PIKALECD_03174	0.0	-	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PIKALECD_03175	4.91e-121	ykkA	-	-	S	-	-	-	Protein of unknown function (DUF664)
PIKALECD_03176	2.4e-97	yuxK	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_03177	1.26e-265	-	-	-	S	-	-	-	Platelet-activating factor acetylhydrolase, isoform II
PIKALECD_03178	5.62e-146	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03179	3.82e-20	binR	-	-	L	-	-	-	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PIKALECD_03180	4.29e-64	-	-	-	-	-	-	-	-
PIKALECD_03181	5.04e-60	-	-	-	-	-	-	-	-
PIKALECD_03182	8.23e-78	-	-	-	-	-	-	-	-
PIKALECD_03183	2.69e-93	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03184	1.39e-83	-	-	-	-	-	-	-	-
PIKALECD_03185	2.83e-69	-	-	-	-	-	-	-	-
PIKALECD_03186	0.0	-	-	-	M	-	-	-	nuclease activity
PIKALECD_03187	4.2e-46	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
PIKALECD_03188	2e-37	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
PIKALECD_03189	9.46e-185	yjqC	-	-	P	ko:K07217	-	ko00000	Catalase
PIKALECD_03190	7.42e-137	ycgF	-	-	E	-	-	-	Lysine exporter protein LysE YggA
PIKALECD_03191	2.89e-308	ycgH	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
PIKALECD_03192	3.86e-150	yhcQ	-	-	M	-	-	-	Spore coat protein
PIKALECD_03193	6.91e-06	-	-	-	S	-	-	-	Sporulation inhibitor A
PIKALECD_03194	1.54e-217	-	4.3.1.12	-	E	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	ko00000,ko00001,ko01000	Ornithine cyclodeaminase/mu-crystallin family
PIKALECD_03195	3.2e-217	eutB	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
PIKALECD_03196	1.24e-266	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
PIKALECD_03197	2.23e-150	-	-	-	S	-	-	-	HTH domain
PIKALECD_03198	8.12e-240	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Arginase family
PIKALECD_03199	2.79e-162	yrkP	-	-	T	ko:K02483	-	ko00000,ko02022	Transcriptional regulator
PIKALECD_03200	1.02e-239	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_03201	1.55e-188	-	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
PIKALECD_03202	3.96e-155	ydfF	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
PIKALECD_03203	5.49e-142	ydfE	-	-	S	-	-	-	Flavin reductase like domain
PIKALECD_03204	1.08e-136	-	-	-	S	-	-	-	ABC-2 family transporter protein
PIKALECD_03205	3.59e-212	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03206	1.72e-200	ycbM	-	-	T	-	-	-	Histidine kinase
PIKALECD_03207	8.26e-154	ycbL	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_03208	2.59e-295	hisD	1.1.1.23, 1.1.1.308	-	E	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PIKALECD_03209	2.25e-218	-	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
PIKALECD_03210	1.18e-293	-	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
PIKALECD_03211	0.0	-	-	-	M	-	-	-	Domain of unknown function DUF11
PIKALECD_03212	5.39e-130	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
PIKALECD_03213	8.68e-44	-	-	-	S	-	-	-	Sporulation inhibitor A
PIKALECD_03214	2.01e-203	-	-	AA10,CBM73	D	ko:K03933	-	ko00000	Lytic polysaccharide mono-oxygenase, cellulose-degrading
PIKALECD_03215	7.14e-183	-	1.1.1.140	-	C	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
PIKALECD_03216	2.8e-72	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
PIKALECD_03217	6.84e-229	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol sorbitol-specific transporter subunit IIB
PIKALECD_03218	3.77e-127	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
PIKALECD_03219	1.16e-97	srlR	-	-	K	-	-	-	Glucitol operon activator
PIKALECD_03220	1.49e-218	-	-	-	K	-	-	-	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
PIKALECD_03221	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
PIKALECD_03222	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
PIKALECD_03223	3.79e-315	yteT	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_03224	2.02e-156	yteU	-	-	S	-	-	-	Integral membrane protein
PIKALECD_03225	1.11e-100	-	-	-	G	-	-	-	carbohydrate transport
PIKALECD_03226	1.5e-278	yteR	3.2.1.172	GH105	G	ko:K15532	-	ko00000,ko01000	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
PIKALECD_03227	0.0	-	3.2.1.37, 3.2.1.55	GH43,GH51	G	ko:K01198,ko:K01209	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
PIKALECD_03228	2.51e-208	-	-	-	E	-	-	-	Abhydrolase family
PIKALECD_03229	1.08e-188	ytcP3	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03230	5.66e-230	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
PIKALECD_03231	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_03232	0.0	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03233	2.6e-201	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_03234	3.23e-246	-	4.2.2.2	-	M	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectic acid lyase
PIKALECD_03235	2.41e-133	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03236	3.11e-164	ytbQ	1.1.1.203, 1.1.1.388	-	GM	ko:K18981,ko:K19243	ko00030,ko00053,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00053,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	NAD dependent epimerase/dehydratase family
PIKALECD_03237	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
PIKALECD_03238	0.0	lplA3	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03239	3.77e-216	lplC1	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03240	4.78e-223	-	-	-	P	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03241	0.0	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
PIKALECD_03242	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_03243	0.0	yicI	3.2.1.177	GH31	G	ko:K01811	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 31 family
PIKALECD_03244	1.86e-253	glcP1	-	-	G	ko:K08174	-	ko00000,ko02000	Major Facilitator Superfamily
PIKALECD_03245	1.22e-225	nagC_1	-	-	GK	-	-	-	ROK family
PIKALECD_03246	0.0	M1-1044	-	-	S	-	-	-	Belongs to the UPF0061 (SELO) family
PIKALECD_03247	1.25e-208	-	-	-	Q	-	-	-	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
PIKALECD_03248	1.34e-174	ygaJ	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
PIKALECD_03249	4.56e-206	-	-	-	S	-	-	-	Alpha beta hydrolase
PIKALECD_03251	2.18e-93	dcd	3.5.4.13	-	F	ko:K01494	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	2'-deoxycytidine 5'-triphosphate deaminase (DCD)
PIKALECD_03252	4.66e-185	-	-	-	P	-	-	-	COG0370 Fe2 transport system protein B
PIKALECD_03253	3.98e-214	yjiA	-	-	S	-	-	-	Cobalamin biosynthesis protein CobW
PIKALECD_03254	2.14e-232	zinT	-	-	S	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
PIKALECD_03255	0.0	psaA3	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Zinc-uptake complex component A periplasmic
PIKALECD_03256	6.12e-167	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
PIKALECD_03257	7.4e-167	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
PIKALECD_03258	0.0	-	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_03259	7.02e-213	-	4.1.2.28, 4.3.3.7	-	EM	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
PIKALECD_03260	4.56e-210	-	4.2.1.141	-	S	ko:K14259	ko00040,map00040	ko00000,ko00001,ko01000	Fumarylacetoacetate (FAA) hydrolase family
PIKALECD_03261	1.23e-182	-	-	-	K	ko:K19333	-	ko00000,ko03000	helix_turn_helix isocitrate lyase regulation
PIKALECD_03262	0.0	-	4.2.1.82	-	EG	ko:K22396	ko00040,map00040	ko00000,ko00001,ko01000	Dehydratase family
PIKALECD_03263	2.6e-316	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
PIKALECD_03264	6.55e-42	-	-	-	K	-	-	-	MerR family transcriptional regulator
PIKALECD_03265	1.55e-174	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
PIKALECD_03266	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PIKALECD_03267	3.97e-131	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
PIKALECD_03268	7.25e-135	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
PIKALECD_03269	2e-56	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG3414 Phosphotransferase system, galactitol-specific IIB component
PIKALECD_03270	0.0	-	2.7.1.194	-	GKT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	COG3711 Transcriptional antiterminator
PIKALECD_03271	5.19e-124	-	-	-	-	-	-	-	-
PIKALECD_03272	5.94e-123	-	-	-	S	-	-	-	TraX protein
PIKALECD_03273	1.72e-125	yrkC	-	-	G	-	-	-	Cupin domain
PIKALECD_03274	3.55e-59	-	-	-	KQ	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_03275	3.23e-276	-	-	-	L	ko:K07487	-	ko00000	Transposase domain (DUF772)
PIKALECD_03277	7.41e-131	-	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
PIKALECD_03279	2.02e-288	-	-	-	L	-	-	-	Transposase IS116/IS110/IS902 family
PIKALECD_03289	1.99e-85	-	-	-	L	-	-	-	Transposase
PIKALECD_03290	2.37e-130	-	-	-	L	ko:K07482	-	ko00000	Integrase
PIKALECD_03291	3.84e-231	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03292	1.37e-160	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
PIKALECD_03293	9.22e-304	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_03294	3.3e-43	-	-	-	-	-	-	-	-
PIKALECD_03295	4.34e-151	-	4.1.3.17	-	H	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	ko00000,ko00001,ko01000	Methyltransferase
PIKALECD_03296	1.7e-199	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
PIKALECD_03297	5.87e-197	-	-	-	I	-	-	-	Domain of unknown function (DUF1932)
PIKALECD_03298	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 2 family
PIKALECD_03299	1.02e-91	-	-	-	K	ko:K22293	-	ko00000,ko03000	FCD
PIKALECD_03300	1.09e-145	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_03301	2.77e-140	-	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
PIKALECD_03302	1.57e-55	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_03303	8.36e-223	-	-	-	G	-	-	-	C4-dicarboxylate ABC transporter permease
PIKALECD_03305	7.74e-128	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_03306	9.34e-139	-	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Citrate synthase, C-terminal domain
PIKALECD_03307	2.77e-230	-	-	-	C	-	-	-	Belongs to the aldehyde dehydrogenase family
PIKALECD_03308	2.2e-139	-	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Alcohol dehydrogenase GroES-like domain
PIKALECD_03309	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
PIKALECD_03310	1e-242	-	-	-	C	-	-	-	acyl-CoA transferases carnitine dehydratase
PIKALECD_03311	2.68e-71	-	-	-	S	-	-	-	ASCH
PIKALECD_03312	4.01e-100	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
PIKALECD_03313	3.22e-69	-	-	-	FG	ko:K02503	-	ko00000,ko04147	Scavenger mRNA decapping enzyme C-term binding
PIKALECD_03314	1.69e-232	cbrA5	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Ferrichrome ABC transporter substrate-binding protein
PIKALECD_03315	0.0	fhuB5	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_03316	3.65e-173	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
PIKALECD_03317	5.82e-192	-	-	-	P	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03318	1.55e-239	-	-	-	P	-	-	-	NMT1-like family
PIKALECD_03320	1.55e-179	-	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
PIKALECD_03321	7.26e-185	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03322	7.16e-232	-	-	-	P	-	-	-	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
PIKALECD_03323	6.78e-225	pucA	1.17.1.4	-	O	ko:K00087,ko:K07402	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PIKALECD_03324	1.05e-129	pucB	1.17.1.4, 2.7.7.76	-	S	ko:K00087,ko:K07141	ko00230,ko00790,ko01100,ko01120,map00230,map00790,map01100,map01120	ko00000,ko00001,ko00002,ko01000	MobA-like NTP transferase domain
PIKALECD_03325	1.15e-202	pucC	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03519	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
PIKALECD_03326	0.0	pucD	1.17.1.4	-	C	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
PIKALECD_03327	2.44e-111	-	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03518	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
PIKALECD_03328	1.04e-309	pucG	2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51	-	E	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	ko00000,ko00001,ko00002,ko01000,ko01007	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
PIKALECD_03329	4.42e-289	pucF	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
PIKALECD_03330	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
PIKALECD_03331	1.92e-113	-	-	-	S	-	-	-	OHCU decarboxylase
PIKALECD_03332	1.19e-224	-	1.7.3.3, 4.1.1.97	-	Q	ko:K16838	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
PIKALECD_03333	3.78e-74	pucM	3.5.2.17	-	S	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
PIKALECD_03334	0.0	-	-	-	S	-	-	-	Membrane
PIKALECD_03335	2.29e-308	allB	3.5.2.5	-	F	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
PIKALECD_03336	8.24e-271	-	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
PIKALECD_03338	5.75e-152	yqjF	-	-	S	ko:K09166	-	ko00000	Uncharacterized conserved protein (COG2071)
PIKALECD_03339	5.71e-52	ycbP	-	-	S	-	-	-	Protein of unknown function (DUF2512)
PIKALECD_03340	2.73e-118	yvdQ	-	-	S	-	-	-	Protein of unknown function (DUF3231)
PIKALECD_03341	2.28e-291	-	-	-	S	-	-	-	Putative esterase
PIKALECD_03342	9.29e-199	tetM	-	-	J	ko:K18220	-	br01600,ko00000,ko01504	Elongation factor G, domain IV
PIKALECD_03344	9.85e-236	-	-	-	GM	-	-	-	NAD dependent epimerase/dehydratase family
PIKALECD_03345	9.39e-182	-	-	-	S	-	-	-	Alpha/beta hydrolase family
PIKALECD_03346	1.78e-118	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03347	3.84e-192	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PIKALECD_03350	1.3e-158	ssuB	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
PIKALECD_03351	2.58e-178	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
PIKALECD_03352	8.27e-237	-	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_03353	4.91e-203	-	-	-	E	-	-	-	Glyoxalase-like domain
PIKALECD_03354	2.66e-173	-	-	-	G	-	-	-	Phosphoenolpyruvate phosphomutase
PIKALECD_03355	2.01e-131	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
PIKALECD_03356	7.93e-59	sdpR	-	-	K	-	-	-	transcriptional
PIKALECD_03357	1.78e-194	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_03358	1.97e-151	mdmC1	-	-	S	-	-	-	O-methyltransferase
PIKALECD_03359	0.0	yrbD	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
PIKALECD_03360	4.61e-168	ycdF	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	Short-chain dehydrogenase reductase sdr
PIKALECD_03361	7.38e-102	-	-	-	S	-	-	-	Bacterial PH domain
PIKALECD_03362	2.12e-23	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
PIKALECD_03363	2.15e-63	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03372	1.21e-57	-	-	-	-	-	-	-	-
PIKALECD_03373	4.67e-41	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
PIKALECD_03374	2.62e-132	-	-	-	K	ko:K16137	-	ko00000,ko03000	Bacterial regulatory proteins, tetR family
PIKALECD_03375	1.27e-251	-	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
PIKALECD_03376	1.2e-49	-	-	-	S	-	-	-	Nucleotidyltransferase substrate binding protein like
PIKALECD_03377	1.02e-27	-	-	-	S	-	-	-	Nucleotidyltransferase domain
PIKALECD_03378	0.0	gerAA	-	-	EG	ko:K06288,ko:K06310	-	ko00000	Spore germination protein
PIKALECD_03379	1.27e-233	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
PIKALECD_03380	3.07e-264	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
PIKALECD_03381	1.95e-223	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_03383	1.78e-192	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PIKALECD_03384	1.58e-207	-	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
PIKALECD_03385	1.53e-141	cpsE	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
PIKALECD_03386	1.24e-63	-	-	-	S	-	-	-	Polysaccharide biosynthesis protein
PIKALECD_03387	4.44e-78	-	-	-	M	-	-	-	TupA-like ATPgrasp
PIKALECD_03388	2.05e-86	-	-	-	M	-	-	-	Glycosyl transferases group 1
PIKALECD_03389	1.73e-14	-	-	-	G	-	-	-	PFAM glycoside hydrolase family 39
PIKALECD_03390	1.18e-99	-	-	-	M	-	-	-	Glycosyl transferases group 1
PIKALECD_03391	2.54e-191	-	-	-	M	-	-	-	Glycosyl Transferase
PIKALECD_03392	3.68e-264	-	2.7.7.13	-	G	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	mannose-1-phosphate guanylyltransferase
PIKALECD_03393	1.18e-306	-	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PIKALECD_03394	2.77e-152	-	-	-	-	-	-	-	-
PIKALECD_03397	3.87e-141	-	-	-	K	-	-	-	intracellular protease amidase
PIKALECD_03398	2e-130	-	1.6.5.2	-	S	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
PIKALECD_03399	3.54e-91	ytcD	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03402	0.0	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03406	0.0	-	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
PIKALECD_03407	2.28e-113	-	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
PIKALECD_03408	3.71e-174	-	-	-	S	-	-	-	CAAX protease self-immunity
PIKALECD_03409	1.9e-316	-	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PIKALECD_03410	2.22e-61	-	-	-	-	-	-	-	-
PIKALECD_03411	1.43e-291	celD	2.7.1.207	-	G	ko:K02761,ko:K02787,ko:K02788	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PIKALECD_03412	7.7e-67	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_03413	1.95e-67	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
PIKALECD_03414	5.75e-267	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
PIKALECD_03415	9e-194	-	-	-	G	-	-	-	BadF/BadG/BcrA/BcrD ATPase family
PIKALECD_03416	8.88e-213	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03418	0.0	-	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
PIKALECD_03419	1.5e-202	appB	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03420	1.12e-214	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
PIKALECD_03421	2.6e-232	-	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03422	1.42e-247	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03423	4.06e-286	-	-	-	E	-	-	-	Peptidase family M28
PIKALECD_03424	0.0	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
PIKALECD_03425	5.97e-285	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_03426	2.74e-285	-	-	-	S	ko:K12941,ko:K21613	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_03430	2.09e-28	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PIKALECD_03432	5.94e-28	-	-	-	L	-	-	-	Transposase, Mutator family
PIKALECD_03433	2.03e-41	-	-	-	L	-	-	-	Transposase, Mutator family
PIKALECD_03435	2.16e-240	-	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03436	1.89e-253	fbpC	3.6.3.30	-	P	ko:K02010,ko:K02052	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
PIKALECD_03437	0.0	sfuB	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03438	0.0	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_03439	1.68e-177	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
PIKALECD_03440	2.13e-255	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_03441	3.37e-162	-	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
PIKALECD_03442	5.28e-185	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PIKALECD_03443	3.36e-46	-	-	-	-	-	-	-	-
PIKALECD_03445	2.89e-92	-	-	-	-	-	-	-	-
PIKALECD_03446	2.5e-189	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_03448	1.8e-254	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
PIKALECD_03449	8.22e-176	ycnC	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03450	4.72e-206	-	-	-	S	ko:K06911	-	ko00000	Belongs to the pirin family
PIKALECD_03451	2.17e-78	ydeP9	-	-	K	-	-	-	HxlR-like helix-turn-helix
PIKALECD_03452	9.05e-313	-	-	-	F	-	-	-	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
PIKALECD_03453	1.26e-211	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
PIKALECD_03454	2.67e-221	-	-	-	P	ko:K07217	-	ko00000	Catalase
PIKALECD_03455	1.97e-49	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
PIKALECD_03457	4.1e-251	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
PIKALECD_03458	1.31e-167	-	-	-	K	ko:K19333	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_03459	6.2e-240	-	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
PIKALECD_03460	3.16e-108	-	-	-	G	ko:K11689	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_03461	3.82e-270	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_03462	2.04e-175	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
PIKALECD_03463	1.3e-117	-	-	-	S	-	-	-	DNA-binding protein with PD1-like DNA-binding motif
PIKALECD_03464	0.0	-	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PIKALECD_03465	1.34e-260	-	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Thiolase, C-terminal domain
PIKALECD_03466	1.87e-72	-	-	-	S	ko:K07068	-	ko00000	DUF35 OB-fold domain, acyl-CoA-associated
PIKALECD_03467	1.85e-302	yoaB	-	-	EGP	-	-	-	the major facilitator superfamily
PIKALECD_03468	1.31e-268	-	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
PIKALECD_03469	1.47e-169	-	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03470	2.97e-170	-	-	-	K	-	-	-	DeoR C terminal sensor domain
PIKALECD_03471	1.24e-103	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose/Galactose Isomerase
PIKALECD_03472	5.3e-239	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
PIKALECD_03473	6.9e-142	-	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
PIKALECD_03474	5.38e-223	-	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Bacterial fructose-1,6-bisphosphatase, glpX-encoded
PIKALECD_03475	8.6e-104	-	-	-	-	-	-	-	-
PIKALECD_03476	0.0	-	-	-	-	-	-	-	-
PIKALECD_03478	3.59e-173	-	-	-	G	-	-	-	ABC transporter (permease)
PIKALECD_03479	9.14e-177	-	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03480	3.53e-247	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03481	2.41e-270	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_03482	3.16e-191	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
PIKALECD_03483	2.41e-209	-	3.2.1.180	GH88	O	ko:K18581	-	ko00000,ko01000	Glycosyl Hydrolase Family 88
PIKALECD_03484	3.92e-285	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2264)
PIKALECD_03485	3.36e-242	-	-	-	S	-	-	-	Heparinase II/III-like protein
PIKALECD_03486	0.0	-	-	-	M	-	-	-	Glycosyl hydrolase family 59
PIKALECD_03487	2.59e-102	-	-	-	S	-	-	-	yiaA/B two helix domain
PIKALECD_03489	0.0	-	-	-	M	-	-	-	Belongs to the BCCT transporter (TC 2.A.15) family
PIKALECD_03491	1.33e-84	-	-	-	S	-	-	-	CRISPR-associated endoribonuclease Cas6
PIKALECD_03492	8.42e-79	-	-	-	-	-	-	-	-
PIKALECD_03493	3.71e-102	-	2.7.7.19	-	J	ko:K00970,ko:K07016	ko03018,map03018	ko00000,ko00001,ko01000,ko02048,ko03019	crispr-associated protein
PIKALECD_03494	4.37e-147	-	-	-	L	ko:K19134	-	ko00000,ko02048	RAMP superfamily
PIKALECD_03495	8.43e-89	-	-	-	L	-	-	-	RAMP superfamily
PIKALECD_03497	3.89e-101	-	-	-	L	-	-	-	RAMP superfamily
PIKALECD_03498	1.2e-132	-	-	-	L	-	-	-	Integrase core domain
PIKALECD_03500	6.41e-126	-	-	-	L	ko:K07497	-	ko00000	HTH-like domain
PIKALECD_03502	4.62e-103	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
PIKALECD_03504	6.49e-87	-	-	-	-	-	-	-	-
PIKALECD_03505	2.1e-50	-	-	-	S	-	-	-	MazG-like family
PIKALECD_03508	8.64e-26	-	-	-	V	ko:K07452	-	ko00000,ko01000,ko02048	ATPase associated with various cellular activities
PIKALECD_03509	1.37e-33	-	-	-	L	-	-	-	Recombinase zinc beta ribbon domain
PIKALECD_03510	0.0	rlmCD	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PIKALECD_03511	1.84e-100	ykuN	-	-	C	ko:K03839	-	ko00000	Flavodoxin
PIKALECD_03512	1.26e-213	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
PIKALECD_03513	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PIKALECD_03514	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
PIKALECD_03515	6.86e-60	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PIKALECD_03516	6.82e-114	yizA	-	-	S	-	-	-	DinB family
PIKALECD_03517	4.25e-222	-	-	-	-	-	-	-	-
PIKALECD_03519	3.53e-207	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
PIKALECD_03520	2.62e-242	yufP	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
PIKALECD_03521	0.0	yufO	3.6.3.17	-	S	ko:K02056	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03522	4.51e-261	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
PIKALECD_03523	1.15e-280	camS	-	-	S	-	-	-	COG4851 Protein involved in sex pheromone biosynthesis
PIKALECD_03524	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PIKALECD_03525	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
PIKALECD_03526	6.62e-165	pcrB	-	-	I	ko:K07094	-	ko00000,ko01000	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PIKALECD_03527	1.76e-195	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
PIKALECD_03528	1.45e-216	fhuG	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_03529	2.12e-221	fhuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_03531	5.18e-34	mepA	-	-	V	-	-	-	MATE efflux family protein
PIKALECD_03532	1.36e-208	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
PIKALECD_03533	0.0	acyII	3.5.1.11	-	S	ko:K01434	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000,ko01002	Penicillin amidase
PIKALECD_03534	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PIKALECD_03535	1.55e-66	yerC	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_03536	0.0	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
PIKALECD_03537	3.51e-251	cfr	2.1.1.224	-	J	ko:K15632	-	ko00000,ko01000,ko01504,ko03009	Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics
PIKALECD_03538	3.98e-205	opuAC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
PIKALECD_03539	1.88e-187	gbuB	-	-	P	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
PIKALECD_03540	4.86e-279	gbuA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
PIKALECD_03541	4.3e-124	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
PIKALECD_03544	5.31e-69	-	-	-	-	-	-	-	-
PIKALECD_03545	4.73e-27	-	-	-	S	ko:K21493	-	ko00000,ko01000,ko02048	Belongs to the WXG100 family
PIKALECD_03546	2.56e-31	-	-	-	-	-	-	-	-
PIKALECD_03547	6.48e-89	-	-	-	S	ko:K21494	-	ko00000,ko02048	SMI1 / KNR4 family
PIKALECD_03548	1.74e-105	-	-	-	-	-	-	-	-
PIKALECD_03549	1.51e-31	-	-	-	-	-	-	-	-
PIKALECD_03550	7.02e-97	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03551	1.17e-77	-	-	-	-	-	-	-	-
PIKALECD_03552	4.18e-86	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03555	1.18e-103	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
PIKALECD_03556	4.09e-95	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03557	1.11e-65	-	-	-	-	-	-	-	-
PIKALECD_03558	4.85e-89	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03559	6.33e-28	yokK	-	-	S	-	-	-	SMI1 / KNR4 family
PIKALECD_03560	4.31e-275	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase, Mutator family
PIKALECD_03561	1.45e-35	-	-	-	S	-	-	-	A nuclease of the HNH/ENDO VII superfamily with conserved WHH
PIKALECD_03562	2.99e-65	-	-	-	-	-	-	-	-
PIKALECD_03564	1.33e-309	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03565	2.95e-46	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
PIKALECD_03566	5.52e-49	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
PIKALECD_03568	9.31e-232	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
PIKALECD_03569	5.04e-278	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
PIKALECD_03570	4.96e-219	yfiL	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
PIKALECD_03571	3.54e-140	-	-	-	KT	-	-	-	LuxR family transcriptional regulator
PIKALECD_03572	1.2e-246	-	-	-	T	-	-	-	Signal transduction histidine kinase
PIKALECD_03573	6.38e-108	ttr	-	-	K	-	-	-	GCN5 family acetyltransferase
PIKALECD_03574	6.4e-193	fhuD9	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
PIKALECD_03575	2.22e-257	-	3.4.17.11	-	E	ko:K01295	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_03576	7.53e-289	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
PIKALECD_03577	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
PIKALECD_03578	2.85e-129	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PIKALECD_03579	9.28e-249	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
PIKALECD_03580	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PIKALECD_03581	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PIKALECD_03582	1.29e-164	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PIKALECD_03583	5.87e-51	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PIKALECD_03584	1.88e-163	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
PIKALECD_03585	4.3e-314	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PIKALECD_03586	9.86e-262	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PIKALECD_03587	2.26e-104	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PIKALECD_03588	2.1e-163	-	-	-	S	-	-	-	CAAX protease self-immunity
PIKALECD_03589	1.18e-125	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_03590	6.93e-147	-	-	-	S	-	-	-	PFAM AIG2 family protein
PIKALECD_03591	9.14e-139	-	-	-	-	-	-	-	-
PIKALECD_03592	1.04e-82	-	-	-	S	-	-	-	Calcium/calmodulin dependent protein kinase II association domain
PIKALECD_03593	7.15e-43	yebG	-	-	S	-	-	-	NETI protein
PIKALECD_03594	8.2e-25	-	-	-	L	-	-	-	Initiator Replication protein
PIKALECD_03595	0.0	-	-	-	S	ko:K07793	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctA family
PIKALECD_03596	2.13e-90	-	-	-	S	ko:K07794	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter TctB family
PIKALECD_03597	1.72e-244	-	-	-	S	ko:K07795	ko02020,map02020	ko00000,ko00001,ko02000	Tripartite tricarboxylate transporter family receptor
PIKALECD_03598	3.15e-154	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
PIKALECD_03599	0.0	-	2.7.13.3	-	T	ko:K02476,ko:K11614,ko:K11637	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
PIKALECD_03600	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	COG0025 NhaP-type Na H and K H antiporters
PIKALECD_03601	5.94e-71	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
PIKALECD_03602	8.37e-184	-	-	-	-	-	-	-	-
PIKALECD_03604	6.93e-08	-	-	-	L	-	-	-	COG3666 Transposase and inactivated derivatives
PIKALECD_03605	0.0	yheH	-	-	V	ko:K18217,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_03606	0.0	yheI	-	-	V	ko:K18216,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_03607	1.06e-275	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase, Mutator family
PIKALECD_03608	1.46e-16	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_03610	2.09e-287	-	-	-	G	-	-	-	Major facilitator Superfamily
PIKALECD_03611	1.92e-53	-	-	-	O	ko:K04083	-	ko00000,ko03110	Hsp33 protein
PIKALECD_03612	1.35e-59	-	-	-	-	-	-	-	-
PIKALECD_03613	1.52e-81	-	-	-	-	-	-	-	-
PIKALECD_03614	7.08e-308	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_03615	9.5e-52	-	-	-	S	-	-	-	Family of unknown function (DUF5344)
PIKALECD_03616	6.38e-41	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
PIKALECD_03617	6.13e-23	-	-	-	-	-	-	-	-
PIKALECD_03619	3.12e-123	ypbQ	-	-	S	ko:K16168	-	ko00000,ko01008	protein conserved in bacteria
PIKALECD_03620	8.51e-267	bcsA	-	-	Q	ko:K16167	-	ko00000,ko01008	Naringenin-chalcone synthase
PIKALECD_03621	3.78e-169	mta	-	-	K	-	-	-	transcriptional
PIKALECD_03622	3.07e-149	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03623	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
PIKALECD_03624	1.85e-202	kduI	5.3.1.17	-	G	ko:K01815	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PIKALECD_03625	1.17e-167	kduD	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03626	5.37e-169	-	-	-	K	-	-	-	DeoR C terminal sensor domain
PIKALECD_03627	2.56e-111	-	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
PIKALECD_03628	1.31e-135	ywrB	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
PIKALECD_03629	2.82e-197	mqnD	-	-	S	ko:K11785	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PIKALECD_03630	3.35e-145	mqnB	3.2.2.26	-	F	ko:K11783	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PIKALECD_03631	0.0	lipA1	-	-	S	-	-	-	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PIKALECD_03632	0.0	-	-	-	K	ko:K02538	-	ko00000,ko03000	transcriptional antiterminator
PIKALECD_03633	7.26e-133	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
PIKALECD_03634	0.0	-	-	-	M	-	-	-	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PIKALECD_03635	1.2e-203	-	-	-	Q	-	-	-	calcium- and calmodulin-responsive adenylate cyclase activity
PIKALECD_03637	4.89e-201	-	-	-	E	ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Substrate binding domain of ABC-type glycine betaine transport system
PIKALECD_03638	6.28e-130	-	-	-	K	ko:K22109	-	ko00000,ko03000	Belongs to the GbsR family
PIKALECD_03639	0.0	gbsA	1.2.1.8	-	C	ko:K00130	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
PIKALECD_03640	4.38e-285	gbsB	1.1.1.1	-	C	ko:K11440	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
PIKALECD_03641	7.2e-173	yvfI	-	-	K	ko:K05799	-	ko00000,ko03000	COG2186 Transcriptional regulators
PIKALECD_03642	1.62e-159	lutC	-	-	S	ko:K00782	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
PIKALECD_03643	0.0	lutB	-	-	C	ko:K18929	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
PIKALECD_03644	2.93e-176	lutA	-	-	C	ko:K18928	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
PIKALECD_03645	0.0	-	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
PIKALECD_03646	1.39e-12	-	-	-	-	-	-	-	-
PIKALECD_03647	6.22e-285	cypA	-	-	C	ko:K15468	-	ko00000,ko01008	Cytochrome P450
PIKALECD_03648	0.0	abgT_2	-	-	H	ko:K12942	-	ko00000	AbgT putative transporter family
PIKALECD_03649	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Molecular chaperone. Has ATPase activity
PIKALECD_03650	6.08e-131	-	-	-	Q	-	-	-	Isochorismatase family
PIKALECD_03651	1.4e-98	ygaO	-	-	-	-	-	-	-
PIKALECD_03652	1.3e-36	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional regulator
PIKALECD_03653	0.0	-	3.1.3.5, 3.6.1.45	-	F	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
PIKALECD_03655	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
PIKALECD_03656	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
PIKALECD_03657	2.35e-215	-	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
PIKALECD_03658	4.3e-193	ykoQ	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
PIKALECD_03659	3.04e-67	yhcN	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PIKALECD_03660	0.0	-	-	-	S	-	-	-	proteins of the AP superfamily
PIKALECD_03661	1.2e-284	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
PIKALECD_03662	2.14e-87	-	-	-	-	-	-	-	-
PIKALECD_03663	8.62e-223	-	-	-	S	-	-	-	Phosphotransferase enzyme family
PIKALECD_03664	1.01e-276	-	-	-	G	-	-	-	Transmembrane secretion effector
PIKALECD_03665	1.2e-32	-	-	-	S	-	-	-	YfhD-like protein
PIKALECD_03666	8.02e-84	-	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
PIKALECD_03667	2.41e-135	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
PIKALECD_03668	1.6e-223	dhaK	2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15	-	G	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	ko00000,ko00001,ko00002,ko01000	Dihydroxyacetone kinase DhaK, subunit
PIKALECD_03669	1.45e-99	M1-431	-	-	S	-	-	-	Protein of unknown function (DUF1706)
PIKALECD_03670	1.83e-96	rmaD	-	-	K	-	-	-	Iron dependent repressor, N-terminal DNA binding domain
PIKALECD_03671	3.14e-258	yvmA	-	-	EGP	-	-	-	Major Facilitator Superfamily
PIKALECD_03672	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PIKALECD_03673	6.1e-294	ulaA	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system ascorbate-specific transporter subunit IIC
PIKALECD_03674	5.98e-55	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
PIKALECD_03675	0.0	-	2.7.1.194	-	GKT	ko:K02821,ko:K03483	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	COG3711 Transcriptional antiterminator
PIKALECD_03676	2.67e-232	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
PIKALECD_03677	8.98e-149	XK27_07680	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
PIKALECD_03678	9.98e-109	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_03679	3.18e-264	-	-	-	S	ko:K06880	-	ko00000,ko01000,ko01504	Erythromycin esterase
PIKALECD_03680	3.75e-215	-	-	-	K	-	-	-	LysR substrate binding domain
PIKALECD_03681	2e-239	dapB	1.4.1.12, 1.4.1.26	-	S	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	ko00000,ko00001,ko01000	Dihydrodipicolinate reductase, N-terminus
PIKALECD_03682	1.9e-312	-	-	-	C	-	-	-	Na+/H+ antiporter family
PIKALECD_03683	2.89e-100	-	-	-	S	-	-	-	glyoxalase bleomycin resistance protein dioxygenase
PIKALECD_03684	0.0	-	-	-	S	-	-	-	AAA-like domain
PIKALECD_03685	0.0	-	-	-	S	-	-	-	the current gene model (or a revised gene model) may contain a frame shift
PIKALECD_03686	3.11e-232	yddH	-	-	M	-	-	-	Lysozyme-like
PIKALECD_03687	2.38e-205	-	-	-	S	-	-	-	Conjugative transposon protein TcpC
PIKALECD_03688	3.36e-31	-	-	-	K	-	-	-	transcriptional regulator
PIKALECD_03689	3.4e-176	-	-	-	S	-	-	-	Alpha/beta hydrolase family
PIKALECD_03691	2.46e-139	-	-	-	L	ko:K07487	-	ko00000	PFAM transposase IS4 family protein
PIKALECD_03692	1.58e-94	-	-	-	L	ko:K07487	-	ko00000	Transposase
PIKALECD_03693	2.24e-134	-	-	-	K	-	-	-	BetI-type transcriptional repressor, C-terminal
PIKALECD_03694	1.46e-150	-	-	-	S	-	-	-	Sap, sulfolipid-1-addressing protein
PIKALECD_03695	2.13e-44	-	-	-	-	-	-	-	-
PIKALECD_03696	1.55e-206	-	-	-	I	-	-	-	Acyltransferase family
PIKALECD_03697	8.22e-41	-	-	-	K	-	-	-	Sigma-70, region 4
PIKALECD_03698	2.2e-42	-	-	-	K	-	-	-	Sigma-70, region 4
PIKALECD_03699	2.67e-52	-	-	-	S	-	-	-	Helix-turn-helix domain
PIKALECD_03700	2.95e-124	ydcL	-	-	L	-	-	-	Belongs to the 'phage' integrase family
PIKALECD_03701	1.68e-184	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
PIKALECD_03702	2.22e-83	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
PIKALECD_03703	5.45e-112	yqeB	-	-	-	-	-	-	-
PIKALECD_03704	1.67e-105	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_03705	5.14e-134	-	-	-	S	-	-	-	ABC1 family
PIKALECD_03708	4.36e-200	ybfI	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_03709	1.28e-224	-	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
PIKALECD_03710	1.18e-46	-	-	-	V	-	-	-	Beta-lactamase
PIKALECD_03711	2.04e-193	-	-	-	V	-	-	-	Beta-lactamase
PIKALECD_03713	3.13e-311	-	-	-	S	-	-	-	Aminoglycoside phosphotransferase
PIKALECD_03714	1.43e-96	-	-	-	K	-	-	-	SpoVT / AbrB like domain
PIKALECD_03715	1.12e-262	yjiC	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
PIKALECD_03716	9e-181	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03717	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
PIKALECD_03718	5.03e-156	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
PIKALECD_03719	1.07e-238	-	-	-	T	-	-	-	Histidine kinase-like ATPases
PIKALECD_03720	4.26e-139	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_03721	1.21e-288	-	-	-	EGP	-	-	-	Transmembrane secretion effector
PIKALECD_03722	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
PIKALECD_03723	8.89e-170	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_03724	3.47e-73	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	GntR family transcriptional regulator
PIKALECD_03725	3.17e-200	CcmA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03726	9.2e-118	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
PIKALECD_03727	2.29e-224	-	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PIKALECD_03728	2.77e-196	penP	3.5.2.6	-	V	ko:K17836,ko:K18766	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	beta-lactamase
PIKALECD_03729	0.0	mecR1	-	-	KTV	ko:K02172,ko:K02547	ko01501,map01501	ko00000,ko00001,ko00002,ko01002,ko01504	BlaR1 peptidase M56
PIKALECD_03730	2.61e-83	blaI	-	-	K	ko:K02171,ko:K02546	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Penicillinase repressor
PIKALECD_03731	1.18e-179	-	-	-	H	ko:K17882	-	ko00000,ko01000,ko01504	KNTase C-terminal domain
PIKALECD_03732	6.41e-83	-	-	-	K	ko:K21903	-	ko00000,ko03000	transcriptional
PIKALECD_03733	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
PIKALECD_03734	3.92e-246	trkA	-	-	P	ko:K07222	-	ko00000	Oxidoreductase
PIKALECD_03735	6.38e-108	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_03736	9.41e-105	-	-	-	-	-	-	-	-
PIKALECD_03737	5.94e-175	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
PIKALECD_03738	8.67e-230	-	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
PIKALECD_03739	4.76e-146	-	-	-	Q	-	-	-	SAM-dependent methyltransferase
PIKALECD_03740	2.15e-180	-	-	-	EG	-	-	-	EamA-like transporter family
PIKALECD_03741	4.64e-166	-	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
PIKALECD_03742	3.88e-136	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_03743	5.53e-84	-	-	-	-	-	-	-	-
PIKALECD_03744	1.12e-89	-	-	-	S	-	-	-	Protein of unknown function (DUF2512)
PIKALECD_03745	4.73e-146	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
PIKALECD_03746	3.68e-107	-	2.3.1.128	-	J	ko:K03789,ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
PIKALECD_03747	0.0	siaT_4	-	-	S	-	-	-	Tripartite ATP-independent periplasmic transporter, DctM component
PIKALECD_03748	3.34e-67	-	-	-	S	-	-	-	Domain of unknown function (DUF1850)
PIKALECD_03749	1.01e-151	-	-	-	S	ko:K07080	-	ko00000	NMT1-like family
PIKALECD_03750	0.0	-	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
PIKALECD_03751	9.05e-152	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
PIKALECD_03752	5.54e-210	ycgS	-	-	I	-	-	-	alpha/beta hydrolase fold
PIKALECD_03753	4.97e-272	yutK	-	-	F	ko:K03317	-	ko00000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PIKALECD_03754	5.39e-126	flaR	-	-	F	-	-	-	topology modulation protein
PIKALECD_03756	4.11e-11	-	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
PIKALECD_03757	7.51e-111	ftnA	1.16.3.2	-	P	ko:K02217	-	ko00000,ko01000	Iron-storage protein
PIKALECD_03758	4.9e-217	yueF	-	-	S	-	-	-	transporter activity
PIKALECD_03759	0.0	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PIKALECD_03760	9.04e-130	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
PIKALECD_03761	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
PIKALECD_03762	4.09e-276	-	-	-	G	-	-	-	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
PIKALECD_03763	8.48e-106	-	-	-	G	-	-	-	Tripartite ATP-independent periplasmic transporters, DctQ component
PIKALECD_03764	5.04e-233	-	-	-	G	-	-	-	Bacterial extracellular solute-binding protein, family 7
PIKALECD_03765	5.31e-217	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
PIKALECD_03766	4.59e-173	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
PIKALECD_03767	0.0	yvcC1	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
PIKALECD_03768	2.19e-188	murR	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03769	1.19e-232	pdxA	1.1.1.408, 1.1.1.409	-	H	ko:K22024	-	ko00000,ko01000	Belongs to the PdxA family
PIKALECD_03770	1.08e-303	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
PIKALECD_03771	3.28e-213	kdgT	-	-	P	ko:K02526	-	ko00000,ko02000	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
PIKALECD_03773	0.0	-	-	-	K	-	-	-	Propionate catabolism activator
PIKALECD_03774	1.55e-195	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PIKALECD_03775	1.06e-298	ybbF	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_03776	9.5e-241	yleB	4.2.1.126	-	S	ko:K07106,ko:K09963	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Bacterial protein of unknown function (DUF871)
PIKALECD_03777	8.01e-229	purR15	-	-	K	ko:K02529	-	ko00000,ko03000	Bacterial regulatory proteins, lacI family
PIKALECD_03778	0.0	ydhP	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
PIKALECD_03779	1.29e-191	-	-	-	GK	-	-	-	ROK family
PIKALECD_03780	7.03e-194	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03781	5.44e-207	-	-	-	P	ko:K02026,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
PIKALECD_03782	6.59e-278	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03783	2.42e-189	manA3	3.2.1.78	GH26	G	ko:K01218	ko00051,ko02024,map00051,map02024	ko00000,ko00001,ko01000	Endoglucanase
PIKALECD_03784	8.39e-47	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
PIKALECD_03785	1.51e-17	-	-	-	-	-	-	-	-
PIKALECD_03786	1.35e-126	-	-	-	S	-	-	-	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
PIKALECD_03787	9.12e-174	-	-	-	C	-	-	-	alcohol dehydrogenase
PIKALECD_03788	4.47e-99	-	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03789	3.23e-70	fdx5	-	-	C	-	-	-	2Fe-2S iron-sulfur cluster binding domain
PIKALECD_03790	1.06e-28	-	-	-	-	-	-	-	-
PIKALECD_03791	0.0	-	-	-	KT	-	-	-	Transcriptional regulator
PIKALECD_03792	1.89e-275	adhB	1.1.1.1, 1.1.1.202	-	C	ko:K00001,ko:K00086	ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
PIKALECD_03793	3.31e-284	-	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
PIKALECD_03794	7.35e-221	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
PIKALECD_03795	2.98e-252	-	-	-	C	ko:K19954	-	ko00000,ko01000	alcohol dehydrogenase
PIKALECD_03796	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_03797	0.0	-	-	-	EG	ko:K06295	-	ko00000	Bacillus/Clostridium GerA spore germination protein
PIKALECD_03798	6.42e-84	-	-	-	-	-	-	-	-
PIKALECD_03799	3.43e-114	ectA	2.3.1.178	-	K	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	ko00000,ko00001,ko00002,ko01000	L-2,4-diaminobutyric acid acetyltransferase
PIKALECD_03800	6.07e-311	ectB	2.6.1.76	-	E	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PIKALECD_03801	1.59e-99	ectC	4.2.1.108	-	S	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
PIKALECD_03802	0.0	-	-	-	G	ko:K02027,ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter substrate-binding protein
PIKALECD_03803	9.78e-188	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_03804	9.2e-210	-	-	-	G	ko:K02025,ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
PIKALECD_03805	6.89e-190	-	-	-	P	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_03806	6.37e-247	-	3.6.3.20	-	P	ko:K05816	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03808	5e-285	-	-	-	KLT	-	-	-	Protein kinase domain
PIKALECD_03811	4.87e-96	-	-	-	H	-	-	-	Tellurite resistance protein TehB
PIKALECD_03812	1.38e-64	-	-	-	S	-	-	-	ABC-2 family transporter protein
PIKALECD_03813	0.0	alkK	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
PIKALECD_03814	0.0	-	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
PIKALECD_03815	1.65e-256	yhfS	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
PIKALECD_03816	1.18e-184	dhrS4	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
PIKALECD_03817	1.41e-241	yneE	-	-	K	-	-	-	Arabinose-binding domain of AraC transcription regulator, N-term
PIKALECD_03819	1.85e-96	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
PIKALECD_03820	1.39e-297	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PIKALECD_03821	0.0	-	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
PIKALECD_03822	3.14e-255	ugpC	3.6.3.20	-	P	ko:K05816,ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
PIKALECD_03823	2.71e-207	ugpA	-	-	G	ko:K02025,ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
PIKALECD_03824	1.36e-177	ugpE	-	-	P	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter permease
PIKALECD_03825	4.49e-300	ugpB	-	-	G	ko:K02027,ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Glycerol-3-phosphate ABC transporter substrate-binding protein
PIKALECD_03826	7.11e-174	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
PIKALECD_03827	1.77e-262	-	-	-	EGP	ko:K08162	-	ko00000,ko02000	Major Facilitator Superfamily
PIKALECD_03828	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03829	5.24e-188	-	-	-	G	-	-	-	Haloacid dehalogenase-like hydrolase
PIKALECD_03830	6.89e-119	-	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PIKALECD_03831	6.06e-223	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03832	1.02e-198	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
PIKALECD_03833	6.76e-158	yhdW	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
PIKALECD_03834	5.39e-222	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_03835	1.8e-248	-	1.1.1.361	-	S	ko:K18652	-	ko00000,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
PIKALECD_03836	1.41e-128	ykoP	-	-	G	-	-	-	polysaccharide deacetylase
PIKALECD_03837	4.71e-249	-	-	-	-	-	-	-	-
PIKALECD_03838	4.41e-179	fabG1	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03839	1.43e-184	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
PIKALECD_03840	2.62e-87	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PIKALECD_03841	7.59e-214	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
PIKALECD_03842	0.0	-	-	-	E	-	-	-	amino acid
PIKALECD_03843	7.41e-228	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_03844	0.0	rhaA	2.7.1.5, 5.3.1.14	-	G	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Belongs to the rhamnose isomerase family
PIKALECD_03845	0.0	yuxG	-	-	IQ	-	-	-	Class II Aldolase and Adducin N-terminal domain
PIKALECD_03846	1.87e-68	rhaM	5.1.3.32	-	G	ko:K03534	-	ko00000,ko01000	Involved in the anomeric conversion of L-rhamnose
PIKALECD_03847	6.97e-284	-	-	-	EGP	ko:K06610	-	ko00000,ko02000	Major facilitator superfamily
PIKALECD_03848	1.61e-188	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_03849	5.8e-293	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_03850	6.88e-277	-	-	-	EM	-	-	-	Protein of unknown function (DUF993)
PIKALECD_03851	4.71e-199	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
PIKALECD_03852	1.21e-267	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
PIKALECD_03853	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_03854	2.58e-253	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
PIKALECD_03855	9.51e-316	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03856	5.85e-225	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03857	1.15e-198	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03858	7.01e-247	-	-	-	I	-	-	-	Acyltransferase family
PIKALECD_03859	8.11e-299	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
PIKALECD_03860	5.64e-152	ykoG	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_03861	1.89e-162	-	-	-	S	-	-	-	L-2-amino-thiazoline-4-carboxylic acid hydrolase
PIKALECD_03863	1.25e-71	-	-	-	-	-	-	-	-
PIKALECD_03864	0.0	yesW	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
PIKALECD_03865	1.77e-245	yesW	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
PIKALECD_03866	9.43e-300	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03867	1.91e-192	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03868	7.23e-202	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03869	0.0	abfA	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	alpha-L-arabinofuranosidase activity
PIKALECD_03870	8.87e-306	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_03871	3.57e-204	-	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03872	3.03e-194	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_03873	1.17e-134	-	-	-	S	-	-	-	Protein of unknown function, DUF624
PIKALECD_03874	1.04e-217	M1-640	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03875	1.21e-209	rhaR1	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_03876	6.56e-180	araL	-	-	G	ko:K02101	-	ko00000	Haloacid dehalogenase-like hydrolase
PIKALECD_03877	7.7e-275	egsA	1.1.1.261	-	C	ko:K00096	ko00564,map00564	ko00000,ko00001,ko01000	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
PIKALECD_03878	5.92e-174	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
PIKALECD_03879	0.0	araB	2.7.1.16	-	C	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Belongs to the ribulokinase family
PIKALECD_03880	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
PIKALECD_03881	4.61e-251	chvE	-	-	G	ko:K10546	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
PIKALECD_03882	0.0	araG	3.6.3.17	-	G	ko:K10548	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
PIKALECD_03883	6.41e-247	araH	-	-	G	ko:K10544,ko:K10547	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
PIKALECD_03884	0.0	melA7	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
PIKALECD_03885	1.28e-167	-	-	-	-	-	-	-	-
PIKALECD_03887	4.75e-101	-	-	-	S	-	-	-	Putative small multi-drug export protein
PIKALECD_03888	2.4e-142	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
PIKALECD_03889	6.72e-228	-	-	-	KTV	ko:K01990	-	ko00000,ko00002,ko02000	LytTr DNA-binding domain
PIKALECD_03890	2.37e-62	ykkD_1	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
PIKALECD_03891	2.06e-78	ykkC_1	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
PIKALECD_03892	3.47e-129	yvdT_1	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03893	6.48e-303	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
PIKALECD_03894	1.95e-174	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
PIKALECD_03895	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
PIKALECD_03896	7.71e-188	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
PIKALECD_03897	9.59e-221	iolC	2.7.1.92	-	G	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
PIKALECD_03899	1.66e-250	-	-	-	E	-	-	-	Spore germination protein
PIKALECD_03900	0.0	-	-	-	P	-	-	-	Spore gernimation protein GerA
PIKALECD_03901	6.31e-79	-	-	-	S	-	-	-	Src homology 3 domains
PIKALECD_03902	3.09e-66	-	-	-	-	-	-	-	-
PIKALECD_03903	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
PIKALECD_03904	2.04e-27	-	-	-	S	-	-	-	Protein of unknown function (DUF2564)
PIKALECD_03906	7.87e-236	-	-	-	G	-	-	-	Transmembrane secretion effector
PIKALECD_03907	5.42e-107	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
PIKALECD_03908	1.96e-69	-	-	-	S	-	-	-	Belongs to the HesB IscA family
PIKALECD_03909	0.0	ypwA	3.4.17.19	-	E	ko:K01299	-	ko00000,ko01000,ko01002	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PIKALECD_03910	1.5e-121	-	-	-	U	-	-	-	MarC family integral membrane protein
PIKALECD_03911	3.79e-173	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_03912	1.28e-110	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 1
PIKALECD_03913	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolase family 1
PIKALECD_03914	1.02e-188	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
PIKALECD_03915	1.29e-234	opuBA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
PIKALECD_03916	0.0	proWX	-	-	EM	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
PIKALECD_03917	1.47e-91	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
PIKALECD_03918	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
PIKALECD_03919	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
PIKALECD_03920	3.71e-76	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2200)
PIKALECD_03921	1.88e-106	yocK	-	-	T	-	-	-	general stress protein
PIKALECD_03922	2.57e-255	ytvI	-	-	S	-	-	-	sporulation integral membrane protein YtvI
PIKALECD_03923	7.36e-172	motB	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
PIKALECD_03924	2.45e-178	motA	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
PIKALECD_03925	6.56e-191	yqfU	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
PIKALECD_03926	4.87e-140	-	-	-	S	-	-	-	Golgi phosphoprotein 3 (GPP34)
PIKALECD_03927	4.11e-48	-	-	-	K	-	-	-	COG0202 DNA-directed RNA polymerase, alpha subunit 40 kD subunit
PIKALECD_03928	1.93e-133	ydeI	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
PIKALECD_03929	1.66e-139	yubA	-	-	S	-	-	-	AI-2E family transporter
PIKALECD_03930	1.12e-82	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_03931	3.52e-60	-	-	-	K	-	-	-	PFAM Response regulator receiver domain
PIKALECD_03932	4.35e-115	-	-	-	C	-	-	-	HEAT repeats
PIKALECD_03933	9.65e-59	-	-	-	S	-	-	-	Belongs to the LOG family
PIKALECD_03934	5.44e-88	-	-	-	S	-	-	-	Bacterial PH domain
PIKALECD_03935	4.09e-222	-	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Alpha beta hydrolase
PIKALECD_03936	1.38e-05	-	-	-	F	-	-	-	NUDIX domain
PIKALECD_03937	4.64e-106	yfiT	-	-	S	-	-	-	Belongs to the metal hydrolase YfiT family
PIKALECD_03938	2.64e-75	-	-	-	E	-	-	-	LysE type translocator
PIKALECD_03939	3.35e-128	-	-	-	K	-	-	-	AraC family transcriptional regulator
PIKALECD_03940	7.29e-18	-	-	-	-	-	-	-	-
PIKALECD_03942	1.02e-120	sigY	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
PIKALECD_03943	1e-152	yxlG	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
PIKALECD_03944	3.12e-199	yxlF	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
PIKALECD_03945	1.51e-15	yxlE	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
PIKALECD_03946	1.77e-102	-	-	-	S	-	-	-	Domain of unknown function (DUF4188)
PIKALECD_03947	2.95e-117	-	-	-	K	-	-	-	Virulence activator alpha C-term
PIKALECD_03948	4.19e-194	-	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
PIKALECD_03949	1.06e-99	-	-	-	S	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
PIKALECD_03950	7.85e-159	-	-	-	-	-	-	-	-
PIKALECD_03951	1.58e-55	-	-	-	-	-	-	-	-
PIKALECD_03952	4.24e-270	blt	-	-	EGP	ko:K08153,ko:K19578	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
PIKALECD_03953	1.78e-56	-	-	-	-	-	-	-	-
PIKALECD_03954	1.39e-88	-	-	-	-	-	-	-	-
PIKALECD_03955	1.16e-134	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
PIKALECD_03956	0.0	-	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
PIKALECD_03957	1.28e-06	-	-	-	S	-	-	-	Putative methionine and alanine importer, small subunit
PIKALECD_03958	2.78e-71	yitW	-	-	S	-	-	-	metal-sulfur cluster biosynthetic enzyme
PIKALECD_03960	5.72e-188	ywfM	-	-	EG	ko:K03298	-	ko00000,ko02000	EamA-like transporter family
PIKALECD_03961	1.67e-161	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
PIKALECD_03962	4.45e-187	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
PIKALECD_03963	7.08e-308	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
PIKALECD_03965	8.75e-104	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	D,D-heptose 1,7-bisphosphate phosphatase
PIKALECD_03966	1.97e-196	asbF	4.2.1.118	-	G	ko:K15652	ko00400,ko01110,ko01130,map00400,map01110,map01130	ko00000,ko00001,ko01000	Xylose isomerase-like TIM barrel
PIKALECD_03967	8.91e-232	asbE	-	-	IQ	-	-	-	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PIKALECD_03968	9.05e-55	asbD	-	-	IQ	-	-	-	Phosphopantetheine attachment site
PIKALECD_03969	5.06e-280	asbC	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	AMP-binding enzyme C-terminal domain
PIKALECD_03970	0.0	asbB	-	-	Q	-	-	-	IucA / IucC family
PIKALECD_03971	0.0	asbA	-	-	Q	-	-	-	Siderophore biosynthesis protein
PIKALECD_03973	1.72e-75	yetG	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
PIKALECD_03974	3.09e-266	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
PIKALECD_03975	4.93e-214	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Cysteine synthase
PIKALECD_03976	1.98e-233	ywcH1	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PIKALECD_03977	3.65e-171	spoIISA	-	-	S	ko:K06388	-	ko00000	Toxin SpoIISA, type II toxin-antitoxin system
PIKALECD_03978	6.89e-233	yvbT	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PIKALECD_03979	5.53e-132	yvdT	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_03980	1.26e-288	-	-	-	S	-	-	-	Acetyltransferase
PIKALECD_03981	1.61e-145	-	-	CBM50	M	ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
PIKALECD_03982	0.0	-	-	-	L	-	-	-	COG3666 Transposase and inactivated derivatives
PIKALECD_03983	3.51e-137	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
PIKALECD_03984	1.16e-140	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
PIKALECD_03985	1.74e-181	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
PIKALECD_03986	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
PIKALECD_03987	8.73e-132	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
PIKALECD_03988	1.62e-187	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
PIKALECD_03989	1.64e-261	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
PIKALECD_03990	2.52e-224	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_03991	4.32e-200	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PIKALECD_03993	1.42e-213	-	-	-	M	-	-	-	3D domain
PIKALECD_03994	3.37e-193	-	-	-	M	-	-	-	3D domain
PIKALECD_03995	2.79e-165	yodH	-	-	Q	-	-	-	Methyltransferase
PIKALECD_03996	0.0	gnd	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PIKALECD_03997	1.24e-116	-	-	-	S	-	-	-	Protein of unknown function (DUF1706)
PIKALECD_03998	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PIKALECD_03999	3.03e-68	-	-	-	-	-	-	-	-
PIKALECD_04000	4.63e-174	-	-	-	Q	-	-	-	Methyltransferase domain
PIKALECD_04001	4.81e-94	yyaT	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_04002	3.33e-51	-	-	-	-	-	-	-	-
PIKALECD_04003	6.88e-297	hint	6.5.1.3	-	S	ko:K14415	-	ko00000,ko01000,ko03016	tRNA-splicing ligase RtcB
PIKALECD_04004	9.9e-105	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_04005	1.38e-97	mgsA	4.2.3.3	-	G	ko:K01734	ko00640,ko01120,map00640,map01120	ko00000,ko00001,ko01000	methylglyoxal synthase
PIKALECD_04006	3.39e-183	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
PIKALECD_04007	7.73e-79	ypjD	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
PIKALECD_04008	1.62e-256	-	-	-	L	ko:K07496	-	ko00000	Transposase
PIKALECD_04009	1.83e-200	ypjC	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
PIKALECD_04010	7.3e-270	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
PIKALECD_04011	1.72e-151	yugP	-	-	S	ko:K06973	-	ko00000	Zn-dependent protease
PIKALECD_04012	3.01e-178	-	-	-	S	-	-	-	Sporulation protein YpjB (SpoYpjB)
PIKALECD_04013	4.96e-139	ypjA	-	-	S	-	-	-	membrane
PIKALECD_04014	3.57e-191	qcrC	-	-	C	ko:K03888	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	Menaquinol-cytochrome c reductase cytochrome b c subunit
PIKALECD_04015	8.39e-159	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
PIKALECD_04016	4.26e-118	qcrA	-	-	C	ko:K03886	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Menaquinol-cytochrome c reductase
PIKALECD_04017	8.72e-105	ypiF	-	-	S	-	-	-	Protein of unknown function (DUF2487)
PIKALECD_04018	3.4e-126	ypiB	-	-	S	-	-	-	Belongs to the UPF0302 family
PIKALECD_04019	2.65e-292	ypiA	-	-	S	-	-	-	COG0457 FOG TPR repeat
PIKALECD_04020	3.87e-300	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
PIKALECD_04021	2.48e-254	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
PIKALECD_04022	2.83e-262	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PIKALECD_04023	9.38e-188	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
PIKALECD_04024	2.84e-284	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PIKALECD_04025	7.15e-148	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosylanthranilate isomerase activity
PIKALECD_04026	5.74e-166	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
PIKALECD_04027	4.33e-236	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PIKALECD_04028	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PIKALECD_04029	3.24e-77	aroH	5.4.99.5	-	E	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
PIKALECD_04030	2.1e-247	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PIKALECD_04031	2.07e-280	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PIKALECD_04032	4.6e-179	cheR	2.1.1.80	-	NT	ko:K00575	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko01000,ko02035	COG1352 Methylase of chemotaxis methyl-accepting proteins
PIKALECD_04033	6.26e-101	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
PIKALECD_04034	6.62e-231	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
PIKALECD_04035	2.24e-203	mqnA	4.2.1.151	-	S	ko:K11782	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PIKALECD_04036	8.07e-202	ubiA	2.5.1.39	-	H	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
PIKALECD_04037	1.23e-166	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
PIKALECD_04038	6.72e-73	hepS	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	heptaprenyl diphosphate synthase
PIKALECD_04039	1.85e-48	mtrB	-	-	K	ko:K06285	-	ko00000,ko03000	Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
PIKALECD_04040	6.78e-130	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
PIKALECD_04041	0.0	spoIVA	-	-	S	ko:K06398	-	ko00000	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PIKALECD_04042	5.33e-171	yphF	-	-	-	-	-	-	-
PIKALECD_04043	8.81e-10	yphE	-	-	S	-	-	-	Protein of unknown function (DUF2768)
PIKALECD_04044	2.5e-52	-	-	-	S	-	-	-	Stage VI sporulation protein F
PIKALECD_04045	2.94e-236	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
PIKALECD_04046	2.91e-132	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
PIKALECD_04047	1.29e-314	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
PIKALECD_04049	1.68e-257	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
PIKALECD_04050	7.57e-135	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	1-acyl-sn-glycerol-3-phosphate acyltransferase
PIKALECD_04051	7.12e-151	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
PIKALECD_04052	1.76e-314	ypeB	-	-	H	ko:K06313	-	ko00000	sporulation protein
PIKALECD_04053	1.07e-209	sleB	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Spore cortex-lytic enzyme
PIKALECD_04054	0.0	metH	2.1.1.13	-	E	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
PIKALECD_04055	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
PIKALECD_04056	4.53e-263	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
PIKALECD_04057	4.79e-35	-	-	-	-	-	-	-	-
PIKALECD_04058	3.4e-145	prsW	-	-	S	-	-	-	Involved in the degradation of specific anti-sigma factors
PIKALECD_04059	1.32e-224	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
PIKALECD_04060	2.39e-228	ypdA	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	COG0492 Thioredoxin reductase
PIKALECD_04061	3.06e-303	gudB	1.4.1.2, 1.4.1.4	-	E	ko:K00260,ko:K00262	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
PIKALECD_04062	2.89e-228	-	-	-	-	-	-	-	-
PIKALECD_04063	0.0	-	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
PIKALECD_04064	2.22e-161	-	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_04065	9.54e-140	mecB	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
PIKALECD_04066	3.76e-213	ycgE	-	-	K	ko:K22491	-	ko00000,ko03000	MerR family transcriptional regulator
PIKALECD_04067	1.89e-183	ypbG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
PIKALECD_04068	1.99e-282	-	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
PIKALECD_04070	8.81e-226	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PIKALECD_04071	2.38e-251	-	-	GT4	M	ko:K13678	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
PIKALECD_04072	4.4e-287	-	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyl Transferase
PIKALECD_04074	1.44e-48	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_04075	6.21e-68	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
PIKALECD_04078	6.49e-129	ypbD	-	-	S	ko:K07052	-	ko00000	metal-dependent membrane protease
PIKALECD_04079	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
PIKALECD_04080	3.55e-223	ypbB	5.1.3.1	-	S	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	protein conserved in bacteria
PIKALECD_04081	2.28e-57	fer	-	-	C	ko:K05337	-	ko00000	Ferredoxin
PIKALECD_04082	0.0	serA	1.1.1.399, 1.1.1.95	-	E	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PIKALECD_04083	0.0	nox	1.11.1.1	-	P	ko:K05910	-	ko00000,ko01000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PIKALECD_04084	5e-175	ykoY	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
PIKALECD_04086	1.38e-126	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Adenosyltransferase
PIKALECD_04087	3.67e-180	yvrA	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
PIKALECD_04088	2.85e-244	btuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PIKALECD_04090	0.0	resE	2.7.13.3	-	T	ko:K07651	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_04091	2.69e-167	resD	-	-	T	ko:K07775	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
PIKALECD_04092	3.64e-271	resC	-	-	O	-	-	-	'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
PIKALECD_04093	0.0	resB	-	-	O	ko:K07399	-	ko00000	COG1333 ResB protein required for cytochrome c biosynthesis
PIKALECD_04094	5.06e-126	resA	-	-	CO	-	-	-	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
PIKALECD_04095	4.45e-168	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
PIKALECD_04096	1.65e-101	spmB	-	-	S	ko:K06374	-	ko00000	Spore maturation protein
PIKALECD_04097	8.76e-131	spmA	-	-	S	ko:K06373	-	ko00000	Spore maturation protein
PIKALECD_04098	5.42e-275	dacB	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
PIKALECD_04099	1.46e-73	spoVAE	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
PIKALECD_04100	7.32e-247	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
PIKALECD_04101	3.68e-102	spoVAC	-	-	S	ko:K06405	-	ko00000	stage V sporulation protein AC
PIKALECD_04102	9.36e-60	-	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
PIKALECD_04103	5.02e-158	-	-	-	S	-	-	-	membrane
PIKALECD_04104	9.37e-60	-	-	-	S	-	-	-	ATP synthase, subunit b
PIKALECD_04105	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	ABC1 family
PIKALECD_04106	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PIKALECD_04107	2.19e-216	sodF	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Superoxide dismutase
PIKALECD_04108	0.0	acoD	-	-	C	ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family
PIKALECD_04109	1.67e-135	-	-	-	K	-	-	-	Uncharacterized protein conserved in bacteria (DUF2087)
PIKALECD_04110	1.78e-127	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PIKALECD_04111	9.2e-161	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PIKALECD_04112	3.57e-108	ypuF	-	-	S	ko:K09763	-	ko00000	Domain of unknown function (DUF309)
PIKALECD_04113	1.2e-74	sdaA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
PIKALECD_04116	8.63e-09	-	-	-	S	-	-	-	Uncharacterized small protein (DUF2292)
PIKALECD_04117	5.08e-107	ssuE	1.5.1.38, 1.5.1.45	-	S	ko:K00299,ko:K16902	ko00380,ko00740,ko00920,ko01100,map00380,map00740,map00920,map01100	ko00000,ko00001,ko01000	FMN reductase
PIKALECD_04118	2.72e-216	-	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
PIKALECD_04119	1.78e-265	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
PIKALECD_04120	5.36e-171	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
PIKALECD_04121	1.16e-161	ssuB	-	-	P	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
PIKALECD_04122	1.54e-118	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
PIKALECD_04123	1.58e-202	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
PIKALECD_04124	1.7e-176	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
PIKALECD_04125	3.53e-278	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
PIKALECD_04126	1.89e-234	cysP	-	-	P	ko:K16331	-	ko00000,ko02000	phosphate transporter
PIKALECD_04127	2.08e-144	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
PIKALECD_04128	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
PIKALECD_04129	7.09e-178	cbiX	4.99.1.3	-	C	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	CbiX
PIKALECD_04130	1.58e-127	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
PIKALECD_04131	0.0	cysJ	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PIKALECD_04132	0.0	cysI	1.8.1.2, 1.8.7.1	-	P	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
PIKALECD_04133	1.22e-20	-	-	-	-	-	-	-	-
PIKALECD_04134	2.12e-194	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
PIKALECD_04135	2.84e-77	-	-	-	K	-	-	-	GntR family transcriptional regulator
PIKALECD_04136	9.66e-271	yraM	-	-	S	-	-	-	PrpF protein
PIKALECD_04137	5.33e-88	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctB family
PIKALECD_04138	0.0	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter TctA family
PIKALECD_04139	2.52e-263	-	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
PIKALECD_04140	1.53e-212	yraN	-	-	K	-	-	-	Transcriptional regulator
PIKALECD_04141	2.43e-243	icd	1.1.1.41, 1.1.1.42, 1.1.1.85	-	CE	ko:K00030,ko:K00031,ko:K00052	ko00020,ko00290,ko00480,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate/isopropylmalate dehydrogenase
PIKALECD_04142	0.0	-	-	-	C	ko:K13796	-	ko00000	COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit
PIKALECD_04143	1.91e-236	yjmD	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
PIKALECD_04144	9.57e-269	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
PIKALECD_04145	1.14e-194	yjmF	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
PIKALECD_04146	3.61e-132	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
PIKALECD_04147	1.38e-132	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
PIKALECD_04148	1.55e-233	ybcL	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
PIKALECD_04149	1.1e-30	-	-	-	-	-	-	-	-
PIKALECD_04150	6.32e-27	XK27_00085	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix domain
PIKALECD_04151	4.62e-289	cstA	-	-	T	-	-	-	Carbon starvation protein
PIKALECD_04152	2.49e-248	ycgA	-	-	S	-	-	-	C4-dicarboxylate anaerobic carrier
PIKALECD_04153	2.49e-107	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
PIKALECD_04154	2.76e-162	-	3.4.17.11	-	E	ko:K01295	-	ko00000,ko01000,ko01002	Peptidase dimerisation domain
PIKALECD_04155	1.42e-203	-	-	-	P	-	-	-	Arsenic resistance protein
PIKALECD_04156	4.94e-115	-	-	-	-	-	-	-	-
PIKALECD_04157	2.36e-156	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
PIKALECD_04158	9.97e-59	licB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_04159	9.74e-67	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_04160	5.36e-306	ywbA	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
PIKALECD_04161	8.09e-315	-	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PIKALECD_04162	3.53e-170	celCD	2.7.1.196, 2.7.1.205, 3.5.1.105	-	G	ko:K02759,ko:K03478	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides
PIKALECD_04163	3.4e-176	ybgA	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
PIKALECD_04164	0.0	chiA	3.2.1.14	GH18	G	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Glycoside Hydrolase Family 18
PIKALECD_04165	2.03e-57	-	-	-	S	-	-	-	Family of unknown function (DUF5391)
PIKALECD_04166	7.98e-63	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
PIKALECD_04167	1.72e-285	ybfB	-	-	G	-	-	-	COG0477 Permeases of the major facilitator superfamily
PIKALECD_04168	8.43e-262	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
PIKALECD_04169	3.25e-311	kynU	3.7.1.3	-	E	ko:K01556	ko00380,ko01100,map00380,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively
PIKALECD_04170	7.78e-150	kynB	3.5.1.9	-	S	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PIKALECD_04171	6.1e-197	kynA	1.13.11.11	-	E	ko:K00453	ko00380,ko01100,map00380,map01100	ko00000,ko00001,ko00002,ko01000	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety
PIKALECD_04172	3.37e-254	-	-	-	E	ko:K06296	-	ko00000,ko02000	Spore germination protein
PIKALECD_04174	6.22e-267	gerAC1	-	-	S	ko:K06297	-	ko00000	spore germination
PIKALECD_04175	0.0	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
PIKALECD_04176	3.94e-171	-	-	-	K	-	-	-	DeoR C terminal sensor domain
PIKALECD_04177	6.68e-300	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
PIKALECD_04178	3.07e-240	pdxA	1.1.1.408, 1.1.1.409	-	H	ko:K22024	-	ko00000,ko01000	Belongs to the PdxA family
PIKALECD_04179	2.2e-282	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	GntP family permease
PIKALECD_04180	1.91e-195	araQ5	-	-	P	ko:K10190,ko:K10242	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_04181	2.42e-208	cebF	-	-	P	ko:K10189,ko:K10241,ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
PIKALECD_04182	8.16e-291	lacE3	-	-	G	ko:K10240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 1
PIKALECD_04185	9.78e-317	argE	-	-	E	ko:K20895	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Acetylornithine deacetylase
PIKALECD_04186	2.06e-159	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PIKALECD_04187	8.17e-244	-	-	-	G	-	-	-	Acyltransferase family
PIKALECD_04188	5.45e-205	-	-	-	P	-	-	-	YhfZ C-terminal domain
PIKALECD_04189	2.33e-74	-	-	-	S	-	-	-	PRD domain
PIKALECD_04190	4e-76	-	-	-	S	-	-	-	Protein of unknown function DUF2620
PIKALECD_04191	9.85e-283	-	-	-	S	-	-	-	Protein of unknown function
PIKALECD_04192	1.13e-218	php	-	-	S	ko:K07048	-	ko00000	Phosphotriesterase family
PIKALECD_04193	6.17e-261	-	-	-	E	-	-	-	Cys/Met metabolism PLP-dependent enzyme
PIKALECD_04194	1.68e-274	-	-	-	E	-	-	-	Alanine racemase, N-terminal domain
PIKALECD_04195	3.76e-288	-	-	-	G	-	-	-	Metalloenzyme superfamily
PIKALECD_04196	0.0	-	-	-	O	-	-	-	DnaJ molecular chaperone homology domain
PIKALECD_04197	0.0	hscC	-	-	O	ko:K04045	-	ko00000,ko03110	Hsp70 protein
PIKALECD_04198	1.89e-181	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
PIKALECD_04199	1.32e-193	ydeO	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
PIKALECD_04200	8.33e-187	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
PIKALECD_04201	5.83e-221	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_04202	8.31e-313	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_04203	3.52e-195	M1-465	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_04204	1.29e-202	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_04205	1.48e-64	esxA	-	-	S	-	-	-	Belongs to the WXG100 family
PIKALECD_04206	7.61e-52	yukD	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukD
PIKALECD_04207	4.04e-273	essB	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukC
PIKALECD_04208	0.0	essC	-	-	D	ko:K03466	-	ko00000,ko03036	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
PIKALECD_04209	0.0	yueB	-	-	S	-	-	-	domain protein
PIKALECD_04210	2.93e-92	-	-	-	S	-	-	-	Family of unknown function (DUF5383)
PIKALECD_04211	1.04e-60	-	-	-	-	-	-	-	-
PIKALECD_04212	2.44e-65	-	-	-	-	-	-	-	-
PIKALECD_04213	4.66e-105	-	-	-	-	-	-	-	-
PIKALECD_04214	2.11e-176	-	-	-	S	-	-	-	nuclease activity
PIKALECD_04217	6.7e-05	-	-	-	S	-	-	-	LXG domain of WXG superfamily
PIKALECD_04223	3.94e-66	-	-	-	-	-	-	-	-
PIKALECD_04225	1.46e-63	-	-	-	-	-	-	-	-
PIKALECD_04227	1.22e-218	-	-	-	G	-	-	-	Glycoside hydrolase family 16
PIKALECD_04232	1.38e-165	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
PIKALECD_04233	0.0	-	-	-	Q	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
PIKALECD_04234	8.17e-114	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
PIKALECD_04235	1.27e-180	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
PIKALECD_04236	7.94e-150	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PIKALECD_04237	0.0	ptsG	2.7.1.199, 2.7.1.208	-	G	ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_04238	9.03e-297	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
PIKALECD_04239	3.09e-101	scdA	-	-	D	ko:K07322	-	ko00000	Di-iron-containing protein involved in the repair of iron-sulfur clusters
PIKALECD_04240	0.0	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PIKALECD_04241	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase, beta
PIKALECD_04242	1.6e-149	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	Nitrate reductase delta subunit
PIKALECD_04243	9.42e-163	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	nitrate reductase, gamma subunit
PIKALECD_04244	1.19e-107	nreA	-	-	T	ko:K10851	ko02020,map02020	ko00000,ko00001	phosphoenolpyruvate-protein phosphotransferase activity
PIKALECD_04245	1.23e-251	nreB	2.7.13.3	-	T	ko:K07683,ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
PIKALECD_04246	3.81e-142	nreC	-	-	T	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PIKALECD_04247	0.0	narK	-	-	P	ko:K02575,ko:K10850	ko00910,ko02020,map00910,map02020	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
PIKALECD_04248	2.43e-157	-	-	-	S	-	-	-	YwiC-like protein
PIKALECD_04249	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
PIKALECD_04250	0.0	-	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_04251	2.52e-282	-	-	-	T	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
PIKALECD_04252	2.63e-218	-	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_04253	1.77e-204	ytcP1	-	-	U	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
PIKALECD_04254	3.28e-52	-	-	-	-	-	-	-	-
PIKALECD_04255	1.72e-129	yvrI	-	-	K	ko:K03093	-	ko00000,ko03021	RNA polymerase
PIKALECD_04256	9.59e-140	apl	3.1.3.1	-	S	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	SNARE associated Golgi protein
PIKALECD_04257	0.0	melA	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
PIKALECD_04258	1.66e-214	-	-	-	K	-	-	-	AraC-like ligand binding domain
PIKALECD_04259	8.57e-248	des	1.14.19.23, 1.14.19.45	-	I	ko:K10255	ko02020,map02020	ko00000,ko00001,ko01000,ko01004	fatty acid desaturase
PIKALECD_04260	9.78e-258	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
PIKALECD_04261	1.21e-137	desR	-	-	T	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
PIKALECD_04262	3.13e-282	mgtE	-	-	P	ko:K06213	-	ko00000,ko02000	Acts as a magnesium transporter
PIKALECD_04263	2.52e-98	-	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
PIKALECD_04264	9.15e-72	-	-	-	-	-	-	-	-
PIKALECD_04265	6.71e-113	-	3.1.1.29	-	K	ko:K01056	-	ko00000,ko01000,ko03012	-acetyltransferase
PIKALECD_04266	2.54e-306	-	-	-	EK	-	-	-	Alanine-glyoxylate amino-transferase
PIKALECD_04267	5.3e-104	yvbK	-	-	K	-	-	-	acetyltransferase
PIKALECD_04268	3.43e-187	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
PIKALECD_04269	1.21e-104	-	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PIKALECD_04270	3.96e-256	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
PIKALECD_04271	5.87e-238	-	-	-	KT	ko:K02647	-	ko00000,ko03000	Sugar diacid utilization regulator
PIKALECD_04272	1.13e-250	yetN	-	-	S	-	-	-	Protein of unknown function (DUF3900)
PIKALECD_04273	3.95e-160	-	-	-	-	-	-	-	-
PIKALECD_04274	4.33e-146	ppiB	5.2.1.8	-	O	ko:K01802,ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PIKALECD_04275	2.23e-235	qor	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
PIKALECD_04276	4.18e-196	hisJ3	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	PHP domain
PIKALECD_04277	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
PIKALECD_04278	3.7e-123	sipW	3.4.21.89	-	U	ko:K13280	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase
PIKALECD_04279	1.76e-165	-	-	-	-	ko:K06336	-	ko00000,ko01002	-
PIKALECD_04280	1.19e-121	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
PIKALECD_04281	4.52e-168	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PIKALECD_04282	4.06e-223	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
PIKALECD_04283	6.51e-179	-	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
PIKALECD_04284	2.87e-216	yfhM	3.8.1.5	-	S	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Alpha beta hydrolase
PIKALECD_04285	2.55e-285	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PIKALECD_04287	1.32e-252	aprE	3.4.21.62	-	O	ko:K01342	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
PIKALECD_04288	1.29e-297	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
PIKALECD_04289	3.58e-135	cwlK	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	Peptidase M15B and M15C DD-carboxypeptidase VanY endolysin
PIKALECD_04290	7.54e-315	-	-	-	E	ko:K03294,ko:K14052	-	ko00000,ko02000	Amino acid permease
PIKALECD_04291	9.9e-202	sseA	2.8.1.1, 2.8.1.2	-	P	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	ko00000,ko00001,ko01000	sulfurtransferase
PIKALECD_04292	2.53e-282	yukF	-	-	QT	-	-	-	Transcriptional regulator
PIKALECD_04293	1.31e-249	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
PIKALECD_04294	4e-75	-	1.14.12.7	-	P	ko:K18068	ko00624,ko01100,ko01120,ko01220,map00624,map01100,map01120,map01220	br01602,ko00000,ko00001,ko00002,ko01000	PFAM Rieske 2Fe-2S domain protein
PIKALECD_04295	5.21e-93	yneE	-	-	S	-	-	-	Sporulation inhibitor of replication protein sirA
PIKALECD_04296	8.21e-39	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
PIKALECD_04297	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_04298	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
PIKALECD_04299	2.41e-106	yneK	-	-	S	-	-	-	Protein of unknown function (DUF2621)
PIKALECD_04300	1.22e-19	-	-	-	-	-	-	-	-
PIKALECD_04302	0.0	citB	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PIKALECD_04304	2.3e-06	-	-	-	S	-	-	-	Fur-regulated basic protein B
PIKALECD_04305	3.93e-17	sspN	-	-	S	ko:K06431	-	ko00000	Small acid-soluble spore protein N family
PIKALECD_04306	1.95e-175	-	-	-	P	ko:K07245	-	ko00000,ko02000	Copper resistance protein D
PIKALECD_04307	0.0	spoVK_1	-	-	O	-	-	-	stage V sporulation protein K
PIKALECD_04308	2.92e-98	yneP	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
PIKALECD_04309	5.64e-195	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
PIKALECD_04310	4.8e-104	-	-	-	S	-	-	-	Domain of unknown function (DUF4352)
PIKALECD_04311	5.83e-230	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PIKALECD_04312	9.32e-189	-	-	-	I	-	-	-	Hydrolase
PIKALECD_04313	3.74e-303	ykuI	-	-	T	-	-	-	Diguanylate phosphodiesterase
PIKALECD_04314	7.35e-31	-	-	-	-	-	-	-	-
PIKALECD_04315	2.41e-42	-	-	-	S	-	-	-	YppG-like protein
PIKALECD_04316	3.03e-91	hspX	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
PIKALECD_04317	7.88e-215	-	3.4.13.19	-	E	ko:K01273	-	ko00000,ko00537,ko01000,ko01002,ko04147	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog
PIKALECD_04318	4.7e-202	cheV	-	-	T	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	Chemotaxis protein CheV
PIKALECD_04320	7.87e-66	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
PIKALECD_04321	6.64e-114	msrA	1.8.4.11	-	O	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PIKALECD_04322	3.48e-268	-	-	-	I	ko:K01066	-	ko00000,ko01000	COG0657 Esterase lipase
PIKALECD_04323	4.61e-57	-	-	-	S	-	-	-	DNA alkylation repair protein
PIKALECD_04324	7.16e-236	qoxA	1.10.3.12	-	C	ko:K02826	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
PIKALECD_04325	0.0	qoxB	1.10.3.12	-	C	ko:K02827	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PIKALECD_04326	2.33e-142	qoxC	1.10.3.12	-	C	ko:K02828	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
PIKALECD_04327	1.8e-66	qoxD	1.10.3.12	-	C	ko:K02829	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
PIKALECD_04328	4.7e-57	ywcE	-	-	S	-	-	-	Required for proper spore morphogenesis. Important for spore germination
PIKALECD_04329	3.51e-53	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
PIKALECD_04330	2.5e-313	agcS	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
PIKALECD_04331	4.84e-297	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
PIKALECD_04332	3.71e-161	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PIKALECD_04333	4.48e-98	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
PIKALECD_04334	6.34e-154	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
PIKALECD_04335	9.26e-123	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PIKALECD_04336	3.83e-132	-	-	-	KT	ko:K02479	-	ko00000,ko02022	LuxR family transcriptional regulator
PIKALECD_04337	3.03e-238	-	-	-	T	-	-	-	Histidine kinase
PIKALECD_04338	1.93e-146	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
PIKALECD_04339	5.97e-158	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
PIKALECD_04340	3.78e-213	sagG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
PIKALECD_04342	0.0	-	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PIKALECD_04343	2.54e-96	ymaD	-	-	O	-	-	-	redox protein, regulator of disulfide bond formation
PIKALECD_04345	3.06e-150	-	-	-	M	ko:K21471,ko:K21472	-	ko00000,ko01000,ko01002,ko01011	lytic transglycosylase activity
PIKALECD_04346	8.84e-229	-	-	-	Q	-	-	-	O-methyltransferase
PIKALECD_04348	0.0	odhA	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
PIKALECD_04349	2.89e-251	odhB	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
PIKALECD_04350	9.15e-45	yozC	-	-	-	-	-	-	-
PIKALECD_04351	0.0	ykpA	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
PIKALECD_04352	5.94e-198	yvgN	-	-	S	-	-	-	reductase
PIKALECD_04353	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
PIKALECD_04354	1.32e-74	ytxJ	-	-	O	-	-	-	Protein of unknown function (DUF2847)
PIKALECD_04355	6.1e-116	yocC	-	-	-	-	-	-	-
PIKALECD_04356	2.08e-132	yokL3	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
PIKALECD_04357	2.96e-212	-	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	Helix-hairpin-helix class 2 (Pol1 family) motifs
PIKALECD_04358	1.15e-160	bshB2	-	-	S	ko:K22135	-	ko00000,ko01000	deacetylase
PIKALECD_04359	1.15e-79	yojF	-	-	S	-	-	-	Protein of unknown function (DUF1806)
PIKALECD_04360	2.3e-146	mucD	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PIKALECD_04361	1.03e-87	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
PIKALECD_04363	7.3e-271	ydbM	-	-	I	-	-	-	acyl-CoA dehydrogenase
PIKALECD_04364	7.08e-295	-	-	-	S	-	-	-	membrane
PIKALECD_04365	1.72e-75	-	-	-	-	-	-	-	-
PIKALECD_04366	0.0	tagE6	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
PIKALECD_04367	7.21e-47	-	-	-	-	-	-	-	-
PIKALECD_04368	2.57e-112	-	-	-	S	-	-	-	DinB superfamily
PIKALECD_04370	3.27e-19	-	-	-	-	-	-	-	-
PIKALECD_04371	1.09e-05	-	-	-	-	-	-	-	-
PIKALECD_04372	1.33e-171	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
PIKALECD_04373	0.0	-	2.7.1.199, 2.7.1.208	-	G	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
PIKALECD_04374	0.0	-	4.3.2.2, 5.5.1.2	-	F	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminus
PIKALECD_04375	5.53e-159	-	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
PIKALECD_04376	1.07e-61	-	-	-	-	-	-	-	-
PIKALECD_04380	1.43e-85	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
PIKALECD_04381	1.71e-38	-	-	-	-	-	-	-	-
PIKALECD_04384	5.73e-23	-	-	-	-	-	-	-	-
PIKALECD_04386	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
PIKALECD_04387	1.14e-173	-	3.5.1.105	-	G	ko:K03478	-	ko00000,ko01000	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides
PIKALECD_04388	6.57e-309	glvA	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
PIKALECD_04389	3.64e-160	-	-	-	K	ko:K11922	-	ko00000,ko03000	UTRA
PIKALECD_04390	2.56e-134	-	-	-	S	-	-	-	CAAX protease self-immunity
PIKALECD_04391	3.12e-212	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
PIKALECD_04392	2.86e-210	ydhU	-	-	P	ko:K07217	-	ko00000	Catalase
PIKALECD_04394	6.37e-189	-	-	-	S	-	-	-	Nucleotidyltransferase domain
PIKALECD_04395	9.35e-161	bshB1	-	-	S	ko:K01463	-	ko00000,ko01000	proteins, LmbE homologs
PIKALECD_04396	2.23e-260	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
PIKALECD_04397	7.27e-248	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
PIKALECD_04398	5.21e-227	birA	6.3.4.15	-	K	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
PIKALECD_04399	3.14e-191	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
PIKALECD_04400	1.64e-209	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PIKALECD_04401	8.4e-85	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PIKALECD_04402	1.01e-223	-	-	-	S	-	-	-	Tetratricopeptide repeat
PIKALECD_04403	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
PIKALECD_04404	1.96e-311	mtaD	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
PIKALECD_04406	8.74e-32	ypmA	-	-	S	-	-	-	Protein of unknown function (DUF4264)
PIKALECD_04407	1.59e-104	ypmB	-	-	S	-	-	-	protein conserved in bacteria
PIKALECD_04408	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	asparaginyl-tRNA
PIKALECD_04409	1.14e-161	dnaD	-	-	L	ko:K02086	-	ko00000	DNA replication protein DnaD
PIKALECD_04410	1.45e-157	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PIKALECD_04411	0.0	ypbR	-	-	S	-	-	-	Dynamin family
PIKALECD_04412	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
PIKALECD_04413	1.41e-149	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
PIKALECD_04414	2.05e-202	yppC	-	-	S	-	-	-	Protein of unknown function (DUF2515)
PIKALECD_04416	1.29e-111	racA	-	-	K	ko:K11686	-	ko00000,ko03036	Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
PIKALECD_04417	9.46e-67	yppE	-	-	S	-	-	-	Bacterial domain of unknown function (DUF1798)
PIKALECD_04418	2.9e-26	-	-	-	-	-	-	-	-
PIKALECD_04419	7.48e-299	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PIKALECD_04420	5.49e-124	yraA	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
PIKALECD_04421	1.16e-214	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
PIKALECD_04422	3.7e-70	yusE	-	-	CO	-	-	-	cell redox homeostasis
PIKALECD_04423	8.94e-100	yphP	-	-	S	-	-	-	Belongs to the UPF0403 family
PIKALECD_04424	6.98e-95	-	-	-	CO	-	-	-	Thioredoxin-like
PIKALECD_04425	4.86e-176	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
PIKALECD_04426	2.63e-195	ypgR	-	-	C	-	-	-	COG0694 Thioredoxin-like proteins and domains
PIKALECD_04427	2.16e-39	-	-	-	-	-	-	-	-
PIKALECD_04428	5.84e-110	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
PIKALECD_04429	8.45e-304	ydbT	-	-	S	ko:K08981	-	ko00000	Membrane
PIKALECD_04430	2.09e-244	-	-	-	S	-	-	-	Protein of unknown function (DUF2777)
PIKALECD_04431	1.34e-209	-	-	-	-	-	-	-	-
PIKALECD_04432	1.12e-196	telA	-	-	P	-	-	-	Belongs to the TelA family
PIKALECD_04434	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase
PIKALECD_04435	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
PIKALECD_04436	1.16e-146	ypjP	-	-	S	-	-	-	YpjP-like protein
PIKALECD_04437	8.96e-51	-	-	-	-	-	-	-	-
PIKALECD_04438	1.54e-80	kapB	-	-	G	ko:K06347	ko02020,map02020	ko00000,ko00001	Kinase associated protein B
PIKALECD_04439	5e-199	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PIKALECD_04440	2.9e-05	-	-	-	S	ko:K06376	-	ko00000	Spo0E like sporulation regulatory protein
PIKALECD_04441	1.1e-108	-	-	-	-	-	-	-	-
PIKALECD_04442	7.58e-188	ycsE	-	-	S	-	-	-	hydrolases of the HAD superfamily
PIKALECD_04443	1.31e-24	-	-	-	-	-	-	-	-
PIKALECD_04444	5.03e-229	ykcA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
PIKALECD_04445	5.9e-137	yahD	-	-	S	ko:K06999	-	ko00000	Carboxylesterase
PIKALECD_04446	2.07e-116	-	-	-	-	-	-	-	-
PIKALECD_04447	2.22e-258	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
PIKALECD_04448	2.3e-237	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
PIKALECD_04449	0.0	gerAA	-	-	EG	ko:K06288,ko:K06310	-	ko00000	Spore germination protein
PIKALECD_04450	0.0	pepF	-	-	E	-	-	-	oligoendopeptidase F
PIKALECD_04451	0.0	yprA	-	-	L	ko:K06877	-	ko00000	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
PIKALECD_04452	6.62e-277	yprB	-	-	L	ko:K07502	-	ko00000	RNase_H superfamily
PIKALECD_04453	3.2e-07	cotD	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
PIKALECD_04454	7.39e-126	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
PIKALECD_04455	1.53e-63	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
PIKALECD_04456	1.73e-89	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
PIKALECD_04457	4.53e-50	-	-	-	-	-	-	-	-
PIKALECD_04458	1.29e-279	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
PIKALECD_04459	1.87e-223	-	-	-	S	-	-	-	Oxidoreductase
PIKALECD_04460	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
PIKALECD_04461	2.86e-81	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
PIKALECD_04462	8.13e-82	-	-	-	-	-	-	-	-
PIKALECD_04463	1.35e-211	-	-	-	NT	-	-	-	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
PIKALECD_04465	2.4e-257	-	-	-	S	ko:K06308	-	ko00000	Spore germination B3/ GerAC like, C-terminal