Read a JSON File

ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
HIEHEPNM_00001	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
HIEHEPNM_00002	1.12e-243	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIEHEPNM_00003	4.9e-207	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HIEHEPNM_00004	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIEHEPNM_00005	2.04e-125	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HIEHEPNM_00006	9.66e-308	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HIEHEPNM_00007	8.3e-105	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding
HIEHEPNM_00008	1.87e-84	divIC	-	-	D	ko:K05589,ko:K13052	-	ko00000,ko03036	cell cycle
HIEHEPNM_00009	2.33e-52	yabO	-	-	J	-	-	-	S4 domain protein
HIEHEPNM_00010	0.0	yabM	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HIEHEPNM_00011	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIEHEPNM_00012	1.05e-131	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HIEHEPNM_00013	5.04e-232	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HIEHEPNM_00014	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HIEHEPNM_00015	2.6e-124	padR	-	-	K	-	-	-	Transcriptional regulator PadR-like family
HIEHEPNM_00016	0.0	-	-	-	S	ko:K01421	-	ko00000	ABC-2 family transporter protein
HIEHEPNM_00017	3.35e-148	-	-	-	S	-	-	-	Flavodoxin-like fold
HIEHEPNM_00018	1.9e-154	-	-	-	S	-	-	-	(CBS) domain
HIEHEPNM_00019	1.69e-167	yciB	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
HIEHEPNM_00020	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HIEHEPNM_00021	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	GXGXG motif
HIEHEPNM_00022	1.33e-111	queT	-	-	S	-	-	-	QueT transporter
HIEHEPNM_00024	2.32e-82	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
HIEHEPNM_00025	5.46e-51	-	-	-	-	-	-	-	-
HIEHEPNM_00026	2.9e-276	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIEHEPNM_00027	2.25e-83	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HIEHEPNM_00028	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HIEHEPNM_00029	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HIEHEPNM_00030	1.77e-189	-	-	-	-	-	-	-	-
HIEHEPNM_00031	1.11e-158	-	-	-	S	-	-	-	Tetratricopeptide repeat
HIEHEPNM_00032	4.49e-159	-	-	-	-	-	-	-	-
HIEHEPNM_00033	3.27e-96	-	-	-	-	-	-	-	-
HIEHEPNM_00034	3.24e-57	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
HIEHEPNM_00035	1.91e-299	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIEHEPNM_00037	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HIEHEPNM_00038	2.23e-279	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HIEHEPNM_00041	4.99e-194	ybbB	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HIEHEPNM_00042	3.09e-103	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HIEHEPNM_00043	1.21e-103	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
HIEHEPNM_00044	6.94e-201	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	biotin lipoate A B protein ligase
HIEHEPNM_00045	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	HD domain protein
HIEHEPNM_00046	1.53e-107	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
HIEHEPNM_00047	3.18e-239	-	-	-	S	-	-	-	DUF218 domain
HIEHEPNM_00048	1.4e-78	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HIEHEPNM_00049	1.16e-95	-	-	-	-	-	-	-	-
HIEHEPNM_00050	6.37e-67	nudA	-	-	S	-	-	-	ASCH
HIEHEPNM_00051	2.2e-225	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIEHEPNM_00052	3.01e-295	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HIEHEPNM_00053	1.84e-281	ysaA	-	-	V	-	-	-	RDD family
HIEHEPNM_00054	1.01e-193	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
HIEHEPNM_00055	1.84e-154	ybbL	-	-	S	ko:K02068	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00056	1.38e-156	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	Uncharacterised protein family (UPF0014)
HIEHEPNM_00057	1.1e-199	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
HIEHEPNM_00058	8.83e-209	ispE	2.7.1.148	-	F	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HIEHEPNM_00059	4.13e-51	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
HIEHEPNM_00060	8e-197	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HIEHEPNM_00061	5.35e-127	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HIEHEPNM_00062	7.18e-187	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
HIEHEPNM_00063	7.89e-105	manR	2.7.1.194, 2.7.1.200, 2.7.1.202	-	G	ko:K02538,ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K03491	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIEHEPNM_00072	1.9e-193	-	-	-	-	-	-	-	-
HIEHEPNM_00073	7.16e-113	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_00074	2.84e-207	-	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
HIEHEPNM_00075	2.66e-248	-	-	-	P	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
HIEHEPNM_00076	5.22e-65	-	-	-	-	-	-	-	-
HIEHEPNM_00077	3.48e-219	-	-	-	P	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
HIEHEPNM_00078	5.52e-215	-	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIEHEPNM_00079	0.0	-	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
HIEHEPNM_00080	6.2e-48	-	-	-	-	-	-	-	-
HIEHEPNM_00081	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_00082	0.0	-	-	-	V	ko:K06147,ko:K06148,ko:K11085,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter transmembrane region
HIEHEPNM_00083	1.87e-88	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HIEHEPNM_00084	1.04e-175	-	2.7.1.39	-	S	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Phosphotransferase enzyme family
HIEHEPNM_00085	3e-154	zmp3	-	-	O	-	-	-	Zinc-dependent metalloprotease
HIEHEPNM_00086	4.47e-32	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
HIEHEPNM_00088	8.61e-79	-	-	-	M	-	-	-	LysM domain
HIEHEPNM_00089	0.0	-	-	-	M	-	-	-	LysM domain
HIEHEPNM_00091	8.09e-65	lciIC	-	-	K	-	-	-	Helix-turn-helix domain
HIEHEPNM_00092	1.55e-117	-	-	-	L	ko:K07448	-	ko00000,ko02048	restriction endonuclease
HIEHEPNM_00093	1.29e-44	-	-	-	L	-	-	-	Plasmid pRiA4b ORF-3-like protein
HIEHEPNM_00095	9.36e-35	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HIEHEPNM_00100	1.47e-15	-	-	-	M	-	-	-	LysM domain
HIEHEPNM_00101	1.85e-67	-	-	-	-	-	-	-	-
HIEHEPNM_00102	9.19e-96	-	-	-	K	-	-	-	Putative DNA-binding domain
HIEHEPNM_00104	4.52e-54	-	-	-	S	-	-	-	Abortive infection C-terminus
HIEHEPNM_00105	6.15e-201	-	-	-	L	-	-	-	Phage integrase family
HIEHEPNM_00106	3.58e-16	-	-	-	S	-	-	-	Domain of unknown function (DUF3173)
HIEHEPNM_00107	1.97e-97	-	-	-	K	ko:K07467	-	ko00000	Replication initiation factor
HIEHEPNM_00108	3.78e-62	-	-	-	L	-	-	-	UvrD/REP helicase N-terminal domain
HIEHEPNM_00109	9.93e-133	-	-	-	L	-	-	-	AAA domain
HIEHEPNM_00110	3.68e-189	yeeC	-	-	P	-	-	-	T5orf172
HIEHEPNM_00111	0.0	-	-	-	L	-	-	-	DEAD-like helicases superfamily
HIEHEPNM_00112	0.0	yeeA	-	-	V	-	-	-	Type II restriction enzyme, methylase subunits
HIEHEPNM_00113	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
HIEHEPNM_00114	3.82e-227	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HIEHEPNM_00115	4.69e-70	-	-	-	-	-	-	-	-
HIEHEPNM_00116	2.59e-55	-	-	-	-	-	-	-	-
HIEHEPNM_00117	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIEHEPNM_00118	6.86e-108	ykhA	3.1.2.20	-	I	ko:K01073	-	ko00000,ko01000	Thioesterase superfamily
HIEHEPNM_00119	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HIEHEPNM_00120	7.41e-37	-	-	-	-	-	-	-	-
HIEHEPNM_00121	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
HIEHEPNM_00122	3.98e-230	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HIEHEPNM_00123	9.11e-106	yjhE	-	-	S	-	-	-	Phage tail protein
HIEHEPNM_00124	1.31e-304	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HIEHEPNM_00125	1.02e-234	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
HIEHEPNM_00126	4.02e-165	gpm2	-	-	G	-	-	-	Phosphoglycerate mutase family
HIEHEPNM_00127	1.69e-218	rhaD	4.1.2.19	-	H	ko:K01629	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
HIEHEPNM_00128	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HIEHEPNM_00129	5.4e-174	cysA	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00130	0.0	-	-	-	E	-	-	-	Amino Acid
HIEHEPNM_00131	4.57e-212	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HIEHEPNM_00132	1.53e-302	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIEHEPNM_00133	1.33e-140	nodB3	-	-	G	-	-	-	Polysaccharide deacetylase
HIEHEPNM_00134	0.0	-	-	-	M	-	-	-	Sulfatase
HIEHEPNM_00135	1.7e-221	-	-	-	S	-	-	-	EpsG family
HIEHEPNM_00136	3.25e-107	-	-	-	D	-	-	-	Capsular exopolysaccharide family
HIEHEPNM_00137	1.45e-126	ywqC	-	-	M	ko:K16554	ko05111,map05111	ko00000,ko00001,ko02000	capsule polysaccharide biosynthetic process
HIEHEPNM_00138	6.29e-314	-	-	-	S	-	-	-	polysaccharide biosynthetic process
HIEHEPNM_00139	2.61e-252	-	-	-	M	-	-	-	Glycosyl transferases group 1
HIEHEPNM_00140	5.35e-151	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HIEHEPNM_00141	1.03e-275	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
HIEHEPNM_00142	0.0	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HIEHEPNM_00143	1.42e-224	-	-	-	M	-	-	-	Dolichyl-phosphate-mannose-protein mannosyltransferase
HIEHEPNM_00144	3.19e-142	-	-	-	M	-	-	-	Acyltransferase family
HIEHEPNM_00145	8.66e-202	ykoT	-	-	M	-	-	-	Glycosyl transferase family 2
HIEHEPNM_00146	4.48e-254	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HIEHEPNM_00147	1.41e-115	-	-	-	-	-	-	-	-
HIEHEPNM_00148	0.0	cps2E	-	-	M	-	-	-	Bacterial sugar transferase
HIEHEPNM_00149	1.09e-170	-	-	-	M	-	-	-	Glycosyltransferase sugar-binding region containing DXD motif
HIEHEPNM_00150	7.75e-146	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
HIEHEPNM_00151	4.63e-225	cps2D	5.1.3.2, 5.1.3.25	-	M	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
HIEHEPNM_00152	7.92e-142	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00153	1.18e-140	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00154	5.86e-189	glnH	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIEHEPNM_00156	1.05e-172	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00157	1.95e-221	-	-	-	-	-	-	-	-
HIEHEPNM_00158	0.000417	-	3.2.1.14	GH18	-	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	-
HIEHEPNM_00159	1.93e-110	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
HIEHEPNM_00160	1.1e-13	-	-	-	-	-	-	-	-
HIEHEPNM_00161	8.86e-145	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase
HIEHEPNM_00162	9.55e-88	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00163	1.41e-201	spl	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC/P60 family
HIEHEPNM_00164	6.53e-309	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIEHEPNM_00165	5.22e-207	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HIEHEPNM_00166	1.38e-71	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HIEHEPNM_00167	6.3e-222	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HIEHEPNM_00168	0.0	malZ	3.2.1.20, 3.2.1.41	CBM48,GH13,GH31	G	ko:K01187,ko:K01200	ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HIEHEPNM_00169	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HIEHEPNM_00170	0.0	glgA	2.4.1.21	GT5	F	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000,ko01003	Synthesizes alpha-1,4-glucan chains using ADP-glucose
HIEHEPNM_00171	2.99e-34	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
HIEHEPNM_00172	3.18e-196	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
HIEHEPNM_00173	1.51e-254	glgC	2.7.7.27	-	H	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HIEHEPNM_00174	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HIEHEPNM_00175	8.73e-262	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
HIEHEPNM_00176	3.35e-169	-	-	-	M	-	-	-	Sortase family
HIEHEPNM_00177	2.51e-184	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIEHEPNM_00178	0.0	fbp	3.1.3.11	-	G	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	phosphatase activity
HIEHEPNM_00179	3.92e-86	spx2	-	-	P	ko:K16509	-	ko00000	ArsC family
HIEHEPNM_00180	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	associated with various cellular activities
HIEHEPNM_00181	2.22e-183	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
HIEHEPNM_00182	5.44e-201	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIEHEPNM_00183	8.73e-96	rfbP	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
HIEHEPNM_00184	3.44e-200	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HIEHEPNM_00185	6.87e-258	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HIEHEPNM_00186	1.81e-139	rfbC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HIEHEPNM_00187	1.25e-207	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HIEHEPNM_00188	6.49e-79	-	-	-	S	-	-	-	SPTR Capsular exopolysaccharide biosynthesis protein (Wzm)
HIEHEPNM_00189	1.52e-09	-	-	-	M	-	-	-	Glycosyl transferase 4-like
HIEHEPNM_00191	8.15e-90	-	-	GT2	M	ko:K12997	-	ko00000,ko01000,ko01003,ko01005	Glycosyl transferase family 2
HIEHEPNM_00192	2.03e-26	-	-	GT2	S	ko:K12990	ko02024,ko02025,map02024,map02025	ko00000,ko00001,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HIEHEPNM_00193	5.05e-46	-	-	-	M	-	-	-	Glycosyl transferases group 1
HIEHEPNM_00194	4.43e-46	-	-	-	S	-	-	-	Glycosyl transferase family 2
HIEHEPNM_00195	1.43e-106	cps2J	-	-	S	-	-	-	Polysaccharide biosynthesis protein
HIEHEPNM_00196	5.29e-146	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
HIEHEPNM_00197	3.46e-148	epsB	-	-	M	-	-	-	biosynthesis protein
HIEHEPNM_00198	1.23e-169	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
HIEHEPNM_00199	5.97e-106	ccl	-	-	S	-	-	-	QueT transporter
HIEHEPNM_00200	7.35e-160	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HIEHEPNM_00201	8.55e-49	XK27_01315	-	-	S	-	-	-	Protein of unknown function (DUF2829)
HIEHEPNM_00202	3.39e-64	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HIEHEPNM_00203	2.07e-149	gpm5	-	-	G	-	-	-	Phosphoglycerate mutase family
HIEHEPNM_00204	2.22e-231	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIEHEPNM_00205	2.37e-249	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIEHEPNM_00206	1.17e-224	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIEHEPNM_00207	1.15e-207	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIEHEPNM_00208	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIEHEPNM_00209	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_00210	5.82e-130	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIEHEPNM_00213	3.61e-77	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
HIEHEPNM_00214	9.79e-279	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HIEHEPNM_00215	3.94e-159	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIEHEPNM_00216	1.36e-46	-	-	-	-	-	-	-	-
HIEHEPNM_00217	1.56e-127	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
HIEHEPNM_00218	9.37e-150	-	-	-	S	-	-	-	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HIEHEPNM_00219	8.52e-268	yaaN	-	-	P	-	-	-	Toxic anion resistance protein (TelA)
HIEHEPNM_00220	0.0	ydiC1	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_00221	6.09e-200	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HIEHEPNM_00222	2.98e-49	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HIEHEPNM_00223	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIEHEPNM_00224	2.93e-109	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA protein
HIEHEPNM_00225	1.91e-185	ylmH	-	-	S	-	-	-	S4 domain protein
HIEHEPNM_00226	6.86e-60	yggT	-	-	D	ko:K02221	-	ko00000,ko02044	integral membrane protein
HIEHEPNM_00227	5.1e-102	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HIEHEPNM_00228	2.19e-290	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIEHEPNM_00229	6.05e-307	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HIEHEPNM_00230	4.67e-196	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HIEHEPNM_00231	3.84e-257	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HIEHEPNM_00232	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HIEHEPNM_00233	3.67e-227	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HIEHEPNM_00234	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HIEHEPNM_00235	8.26e-80	ftsL	-	-	D	-	-	-	cell division protein FtsL
HIEHEPNM_00236	4.57e-217	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HIEHEPNM_00237	1.61e-101	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
HIEHEPNM_00238	1.49e-70	-	-	-	-	-	-	-	-
HIEHEPNM_00239	4.32e-14	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
HIEHEPNM_00240	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIEHEPNM_00242	1.63e-193	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
HIEHEPNM_00243	1.29e-143	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter
HIEHEPNM_00244	2.77e-141	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00245	6.07e-182	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
HIEHEPNM_00246	1.28e-146	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HIEHEPNM_00247	2.13e-113	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
HIEHEPNM_00248	5.62e-193	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
HIEHEPNM_00249	6.84e-229	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
HIEHEPNM_00250	2.01e-151	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
HIEHEPNM_00251	1.63e-147	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HIEHEPNM_00252	5.13e-304	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HIEHEPNM_00253	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HIEHEPNM_00254	3.97e-149	-	-	-	K	ko:K01926	-	ko00000,ko03000	CoA binding domain
HIEHEPNM_00255	1.73e-288	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIEHEPNM_00256	7.69e-275	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HIEHEPNM_00257	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HIEHEPNM_00258	6.83e-109	yebR	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
HIEHEPNM_00259	5.31e-143	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HIEHEPNM_00261	0.0	-	-	-	KL	-	-	-	Helicase conserved C-terminal domain
HIEHEPNM_00262	2.45e-175	-	-	-	S	-	-	-	Domain of unknown function (DUF1998)
HIEHEPNM_00263	2.14e-164	-	2.1.1.37	-	H	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	C-5 cytosine-specific DNA methylase
HIEHEPNM_00264	1.13e-289	-	-	-	E	-	-	-	Amino acid permease
HIEHEPNM_00265	2.4e-180	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
HIEHEPNM_00266	0.0	tex	-	-	K	ko:K06959	-	ko00000	Tex-like protein N-terminal domain protein
HIEHEPNM_00267	3.68e-106	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00268	4.64e-188	-	-	-	-	-	-	-	-
HIEHEPNM_00269	0.0	-	-	-	-	-	-	-	-
HIEHEPNM_00270	1.83e-202	yvfR	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_00271	6.21e-165	XK27_09830	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
HIEHEPNM_00272	1.62e-256	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIEHEPNM_00273	2.93e-133	desR	-	-	K	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
HIEHEPNM_00274	1.04e-135	-	-	-	-	-	-	-	-
HIEHEPNM_00275	8.05e-197	degV	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HIEHEPNM_00276	5.59e-33	-	-	-	D	ko:K19159	-	ko00000,ko02048	Antitoxin component of a toxin-antitoxin (TA) module
HIEHEPNM_00277	6.82e-40	yoeB	-	-	S	ko:K19158	-	ko00000,ko01000,ko02048	YoeB-like toxin of bacterial type II toxin-antitoxin system
HIEHEPNM_00278	1.83e-176	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HIEHEPNM_00279	3.56e-194	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIEHEPNM_00280	2.13e-212	sga	5.1.3.22	-	G	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Xylose isomerase-like TIM barrel
HIEHEPNM_00281	4.27e-176	-	-	-	K	-	-	-	DeoR C terminal sensor domain
HIEHEPNM_00282	1.51e-147	ulaD	4.1.1.85, 4.1.2.43	-	G	ko:K03078,ko:K08093	ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
HIEHEPNM_00283	3.93e-60	sgaB	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_00284	0.0	sgaT	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_00285	1.64e-103	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_00286	2.97e-271	ulaG	-	-	S	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Beta-lactamase superfamily domain
HIEHEPNM_00287	0.0	prtP	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HIEHEPNM_00288	5.44e-56	-	-	-	-	-	-	-	-
HIEHEPNM_00289	2.79e-199	-	-	-	GK	-	-	-	ROK family
HIEHEPNM_00290	3.03e-230	asnA2	3.5.1.1	-	E	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	Asparaginase
HIEHEPNM_00291	1.68e-310	-	-	-	E	-	-	-	Peptidase family M20/M25/M40
HIEHEPNM_00292	2.04e-167	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HIEHEPNM_00293	4.11e-273	-	-	-	EGP	-	-	-	Transporter, major facilitator family protein
HIEHEPNM_00294	5.24e-259	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
HIEHEPNM_00295	6.25e-117	-	-	-	K	ko:K03828	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HIEHEPNM_00296	7.2e-144	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	NUDIX domain
HIEHEPNM_00298	1.53e-126	-	-	-	K	-	-	-	Helix-turn-helix domain
HIEHEPNM_00299	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
HIEHEPNM_00300	2.06e-170	-	-	-	F	-	-	-	NUDIX domain
HIEHEPNM_00301	2.68e-139	pncA	-	-	Q	-	-	-	Isochorismatase family
HIEHEPNM_00302	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HIEHEPNM_00303	6.15e-170	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HIEHEPNM_00304	2.81e-90	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIEHEPNM_00305	0.0	ugpB	-	-	G	ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIEHEPNM_00306	6.89e-191	ugpE	-	-	G	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00307	2.51e-208	-	-	-	P	ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type sugar transport systems, permease components
HIEHEPNM_00308	9.24e-269	ugpC	3.6.3.20	-	E	ko:K05816,ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
HIEHEPNM_00309	7.56e-286	-	-	-	EGP	-	-	-	Transmembrane secretion effector
HIEHEPNM_00310	1.69e-186	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
HIEHEPNM_00311	2.54e-244	-	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_00312	1.47e-185	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HIEHEPNM_00313	5.24e-208	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIEHEPNM_00314	5.58e-104	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_00315	5.03e-192	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HIEHEPNM_00316	3.98e-172	XK27_08455	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_00318	1.76e-258	-	-	-	S	-	-	-	endonuclease exonuclease phosphatase family protein
HIEHEPNM_00319	7.62e-219	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HIEHEPNM_00320	3.72e-202	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
HIEHEPNM_00321	1.23e-96	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HIEHEPNM_00322	3.29e-182	-	-	-	Q	-	-	-	Methyltransferase
HIEHEPNM_00323	2.34e-65	sugE	-	-	U	ko:K11741	-	ko00000,ko02000	Multidrug resistance protein
HIEHEPNM_00324	8.78e-08	-	-	-	S	-	-	-	SpoVT / AbrB like domain
HIEHEPNM_00325	1.17e-178	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_00326	2.59e-75	-	-	-	-	-	-	-	-
HIEHEPNM_00327	2.09e-48	-	-	-	-	-	-	-	-
HIEHEPNM_00328	5.69e-140	-	-	-	S	-	-	-	alpha beta
HIEHEPNM_00329	8.86e-103	yfbM	-	-	K	-	-	-	FR47-like protein
HIEHEPNM_00330	6.78e-100	-	-	-	E	-	-	-	HAD-hyrolase-like
HIEHEPNM_00331	2.78e-170	ptp1	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HIEHEPNM_00332	9.36e-111	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00333	1.69e-158	-	-	-	-	-	-	-	-
HIEHEPNM_00334	1.33e-86	-	-	-	S	-	-	-	ASCH
HIEHEPNM_00335	1.18e-104	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HIEHEPNM_00336	7.69e-254	ysdE	-	-	P	-	-	-	Citrate transporter
HIEHEPNM_00337	2.23e-134	-	-	-	-	-	-	-	-
HIEHEPNM_00338	5.64e-315	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Peptidase dimerisation domain
HIEHEPNM_00339	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIEHEPNM_00340	9.87e-200	-	-	-	-	-	-	-	-
HIEHEPNM_00341	0.0	bgaR	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HIEHEPNM_00342	0.0	-	-	-	G	ko:K03292,ko:K16210	-	ko00000,ko02000	MFS/sugar transport protein
HIEHEPNM_00343	0.0	-	-	-	S	-	-	-	Glycosyl hydrolase family 115
HIEHEPNM_00344	0.0	cadA	-	-	P	-	-	-	P-type ATPase
HIEHEPNM_00345	4.09e-99	hsp1	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Hsp20/alpha crystallin family
HIEHEPNM_00346	1.94e-91	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HIEHEPNM_00347	1.99e-284	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
HIEHEPNM_00348	2.72e-196	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
HIEHEPNM_00349	3.66e-183	yycI	-	-	S	-	-	-	YycH protein
HIEHEPNM_00350	0.0	yycH	-	-	S	-	-	-	YycH protein
HIEHEPNM_00351	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIEHEPNM_00352	5.24e-169	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HIEHEPNM_00353	1.1e-159	-	1.11.1.10	-	S	ko:K00433	-	ko00000,ko01000	Alpha/beta hydrolase family
HIEHEPNM_00354	0.0	arpJ	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00355	3.99e-299	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
HIEHEPNM_00356	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
HIEHEPNM_00357	4.59e-271	ybhE	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HIEHEPNM_00358	3.7e-96	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HIEHEPNM_00359	0.0	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_00360	8.04e-168	-	-	-	K	-	-	-	UbiC transcription regulator-associated domain protein
HIEHEPNM_00361	2.7e-68	pts20B	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_00362	2.91e-72	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose Cellobiose specific IIA subunit
HIEHEPNM_00363	5.23e-140	yokL3	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00364	4.22e-105	-	-	-	F	-	-	-	NUDIX domain
HIEHEPNM_00365	5.71e-116	-	-	-	S	-	-	-	AAA domain
HIEHEPNM_00366	2.24e-146	ycaC	-	-	Q	-	-	-	Isochorismatase family
HIEHEPNM_00367	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_00368	3.01e-273	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	Transporter, major facilitator family protein
HIEHEPNM_00369	7.35e-221	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
HIEHEPNM_00370	1.54e-84	manO	-	-	S	-	-	-	Domain of unknown function (DUF956)
HIEHEPNM_00371	7.33e-218	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HIEHEPNM_00372	6.18e-173	manM	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system
HIEHEPNM_00373	7.73e-231	manL	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_00374	1.62e-277	-	-	-	EGP	-	-	-	Major facilitator Superfamily
HIEHEPNM_00375	6.98e-241	-	-	-	K	ko:K20373	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
HIEHEPNM_00376	3.25e-190	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIEHEPNM_00377	5.07e-203	-	-	-	K	-	-	-	sequence-specific DNA binding
HIEHEPNM_00382	0.0	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HIEHEPNM_00383	0.0	XK27_05795	-	-	P	ko:K17073,ko:K17074	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00384	1.89e-172	glnQ	-	-	E	ko:K17076	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00385	7.62e-53	-	-	-	-	-	-	-	-
HIEHEPNM_00386	3.33e-303	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIEHEPNM_00387	3.97e-23	-	-	-	-	-	-	-	-
HIEHEPNM_00388	1.89e-167	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
HIEHEPNM_00389	7.92e-76	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HIEHEPNM_00390	9.87e-70	-	-	-	-	-	-	-	-
HIEHEPNM_00391	1.9e-104	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
HIEHEPNM_00392	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
HIEHEPNM_00393	8.69e-183	-	-	-	S	-	-	-	AAA ATPase domain
HIEHEPNM_00394	7.03e-213	-	-	-	G	-	-	-	Phosphotransferase enzyme family
HIEHEPNM_00395	7.69e-171	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00396	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_00397	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_00398	1.33e-128	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HIEHEPNM_00399	3.53e-134	-	-	-	S	ko:K06384	-	ko00000	Stage II sporulation protein M
HIEHEPNM_00400	8.18e-215	moxR	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
HIEHEPNM_00401	2.5e-172	-	-	-	S	-	-	-	Protein of unknown function DUF58
HIEHEPNM_00402	0.0	yebA	-	-	E	-	-	-	Transglutaminase/protease-like homologues
HIEHEPNM_00403	4.97e-272	-	-	-	M	-	-	-	Glycosyl transferases group 1
HIEHEPNM_00404	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Fumarase C C-terminus
HIEHEPNM_00405	1.17e-82	yugI	-	-	J	ko:K07570	-	ko00000	general stress protein
HIEHEPNM_00406	5.16e-141	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIEHEPNM_00407	9.5e-238	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
HIEHEPNM_00408	6.48e-115	pgpA	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phosphatidylglycerophosphatase A
HIEHEPNM_00409	4.31e-149	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
HIEHEPNM_00410	8.78e-150	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
HIEHEPNM_00411	4.68e-187	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HIEHEPNM_00412	9.92e-143	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
HIEHEPNM_00413	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HIEHEPNM_00414	1.94e-148	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIEHEPNM_00415	2.41e-153	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
HIEHEPNM_00416	2.32e-238	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
HIEHEPNM_00417	3.48e-73	-	-	-	-	-	-	-	-
HIEHEPNM_00418	0.0	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
HIEHEPNM_00419	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
HIEHEPNM_00420	2.39e-173	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HIEHEPNM_00421	1.24e-162	yfnB	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
HIEHEPNM_00422	3.18e-07	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_00423	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin binding protein transpeptidase domain
HIEHEPNM_00424	6.12e-232	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
HIEHEPNM_00425	2.2e-274	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HIEHEPNM_00426	1.83e-119	yrxA	-	-	S	ko:K07105	-	ko00000	3H domain
HIEHEPNM_00427	8.13e-104	ytxH	-	-	S	-	-	-	YtxH-like protein
HIEHEPNM_00428	7.19e-40	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HIEHEPNM_00430	5.04e-200	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
HIEHEPNM_00431	1.97e-200	-	-	-	S	ko:K08974	-	ko00000	Domain of unknown function (DUF368)
HIEHEPNM_00432	3.12e-110	ykuL	-	-	S	-	-	-	CBS domain
HIEHEPNM_00433	7.42e-172	gla	-	-	U	ko:K02440	-	ko00000,ko02000	Major intrinsic protein
HIEHEPNM_00434	2.24e-123	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
HIEHEPNM_00435	0.0	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HIEHEPNM_00436	1.18e-109	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
HIEHEPNM_00437	5.21e-315	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HIEHEPNM_00438	1.2e-49	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HIEHEPNM_00439	1.46e-305	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
HIEHEPNM_00440	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HIEHEPNM_00441	3.64e-70	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HIEHEPNM_00442	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HIEHEPNM_00443	7.74e-121	cvpA	-	-	S	-	-	-	Colicin V production protein
HIEHEPNM_00444	3.45e-49	-	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HIEHEPNM_00445	1.85e-69	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
HIEHEPNM_00446	3.79e-96	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIEHEPNM_00447	1.4e-57	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
HIEHEPNM_00448	9.14e-259	-	-	-	-	-	-	-	-
HIEHEPNM_00449	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HIEHEPNM_00450	1.2e-07	lacC	2.7.1.144	-	H	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HIEHEPNM_00451	4.08e-219	-	-	-	-	-	-	-	-
HIEHEPNM_00452	0.0	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HIEHEPNM_00453	3.53e-228	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HIEHEPNM_00454	1.54e-305	ytoI	-	-	K	-	-	-	DRTGG domain
HIEHEPNM_00455	2.17e-265	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIEHEPNM_00456	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HIEHEPNM_00457	1.45e-150	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Helix-turn-helix diphteria tox regulatory element
HIEHEPNM_00458	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
HIEHEPNM_00459	2.9e-85	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HIEHEPNM_00460	6.98e-289	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HIEHEPNM_00461	2.16e-264	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HIEHEPNM_00462	4.98e-250	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HIEHEPNM_00463	2.42e-132	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HIEHEPNM_00464	1.25e-134	yjbF	-	-	S	-	-	-	SNARE associated Golgi protein
HIEHEPNM_00465	1.19e-112	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HIEHEPNM_00466	3.84e-280	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
HIEHEPNM_00467	5.25e-96	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
HIEHEPNM_00468	4.32e-148	yviA	-	-	S	-	-	-	Protein of unknown function (DUF421)
HIEHEPNM_00469	9.91e-205	-	-	-	S	-	-	-	Alpha beta hydrolase
HIEHEPNM_00470	1.84e-161	-	-	-	-	-	-	-	-
HIEHEPNM_00471	1.3e-201	dkgB	-	-	S	-	-	-	reductase
HIEHEPNM_00472	2.14e-110	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
HIEHEPNM_00473	2.81e-230	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HIEHEPNM_00474	6.42e-101	-	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_00475	5.26e-155	XK27_05175	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	haloacid dehalogenase-like hydrolase
HIEHEPNM_00476	2.39e-257	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HIEHEPNM_00477	2.66e-119	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIEHEPNM_00478	1.03e-77	-	-	-	-	-	-	-	-
HIEHEPNM_00479	3.53e-227	-	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HIEHEPNM_00480	0.0	yfgQ	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
HIEHEPNM_00481	1.05e-71	-	-	-	-	-	-	-	-
HIEHEPNM_00482	2.01e-102	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Belongs to the NDK family
HIEHEPNM_00483	0.0	pepF	-	-	E	-	-	-	Oligopeptidase F
HIEHEPNM_00484	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_00485	6.46e-218	-	-	-	K	-	-	-	sequence-specific DNA binding
HIEHEPNM_00486	2.95e-123	-	-	-	-	-	-	-	-
HIEHEPNM_00487	1.6e-114	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HIEHEPNM_00488	8.81e-218	mleP	-	-	S	ko:K07088	-	ko00000	Sodium Bile acid symporter family
HIEHEPNM_00489	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
HIEHEPNM_00490	6.96e-206	mleR	-	-	K	-	-	-	LysR family
HIEHEPNM_00491	8.59e-221	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HIEHEPNM_00492	2.41e-81	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
HIEHEPNM_00493	1e-136	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIEHEPNM_00494	8.46e-177	-	-	-	-	-	-	-	-
HIEHEPNM_00495	9.06e-136	-	-	-	S	-	-	-	Flavin reductase like domain
HIEHEPNM_00496	3.6e-215	mleP2	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
HIEHEPNM_00497	6.06e-97	-	-	-	-	-	-	-	-
HIEHEPNM_00498	1e-129	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIEHEPNM_00499	1.99e-36	-	-	-	-	-	-	-	-
HIEHEPNM_00500	5.52e-265	XK27_05220	-	-	S	-	-	-	AI-2E family transporter
HIEHEPNM_00501	6.82e-104	-	-	-	-	-	-	-	-
HIEHEPNM_00502	5.83e-75	-	-	-	-	-	-	-	-
HIEHEPNM_00503	7.49e-237	-	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
HIEHEPNM_00504	1.71e-64	-	-	-	-	-	-	-	-
HIEHEPNM_00505	5.89e-66	ygbF	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
HIEHEPNM_00506	6.52e-75	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HIEHEPNM_00507	7.15e-232	-	-	-	K	-	-	-	sequence-specific DNA binding
HIEHEPNM_00511	1.29e-07	rggD	-	-	K	-	-	-	Transcriptional regulator RggD
HIEHEPNM_00514	7.2e-260	lldD	1.13.12.4	-	C	ko:K00467	ko00620,map00620	ko00000,ko00001,ko01000	IMP dehydrogenase / GMP reductase domain
HIEHEPNM_00515	1.19e-156	ydgI	-	-	C	-	-	-	Nitroreductase family
HIEHEPNM_00516	1.99e-87	-	-	-	S	-	-	-	Belongs to the HesB IscA family
HIEHEPNM_00517	1.87e-307	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
HIEHEPNM_00518	6.13e-165	ciaR	-	-	K	ko:K14983	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
HIEHEPNM_00519	3.17e-11	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_00520	1.59e-14	-	-	-	-	-	-	-	-
HIEHEPNM_00521	2.64e-94	-	-	-	S	-	-	-	GtrA-like protein
HIEHEPNM_00522	0.0	ykcB	-	-	M	-	-	-	Dolichyl-phosphate-mannose-protein mannosyltransferase
HIEHEPNM_00523	8.07e-233	ykcC	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferase family 2
HIEHEPNM_00524	0.0	pacL3	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
HIEHEPNM_00525	2.27e-220	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Zinc-binding dehydrogenase
HIEHEPNM_00526	4.78e-180	-	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00527	1.68e-208	WQ51_06230	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIEHEPNM_00528	3.27e-213	XK27_00670	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_00529	3.73e-214	XK27_00670	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter substrate binding protein
HIEHEPNM_00531	0.0	bglB	3.2.1.21, 3.2.1.52	GH3	G	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	ko00000,ko00001,ko00002,ko01000	hydrolase, family 3
HIEHEPNM_00532	0.0	bmr3	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_00533	1.39e-174	-	-	-	L	ko:K07457	-	ko00000	Base excision DNA repair protein, HhH-GPD family
HIEHEPNM_00534	3.89e-203	pphA	3.1.3.16	-	T	ko:K07313	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HIEHEPNM_00535	1.27e-308	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_00536	9.14e-205	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_00537	0.0	-	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
HIEHEPNM_00538	3.65e-171	-	-	-	K	-	-	-	DeoR C terminal sensor domain
HIEHEPNM_00539	1.7e-279	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIEHEPNM_00540	0.0	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HIEHEPNM_00541	9.43e-73	-	-	-	-	-	-	-	-
HIEHEPNM_00542	4.92e-192	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
HIEHEPNM_00543	0.0	-	-	-	L	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_00545	3.3e-240	ynjC	-	-	S	-	-	-	Cell surface protein
HIEHEPNM_00546	8.2e-177	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_00548	0.0	-	-	-	-	-	-	-	-
HIEHEPNM_00549	9.29e-138	yoaA	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIEHEPNM_00550	4.75e-57	-	-	-	-	-	-	-	-
HIEHEPNM_00551	2.25e-239	mhqA	-	-	E	ko:K15975	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HIEHEPNM_00552	3.44e-70	-	-	-	S	ko:K09004	-	ko00000	DsrE/DsrF-like family
HIEHEPNM_00553	0.0	XK27_07275	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HIEHEPNM_00554	2.83e-71	-	-	-	S	-	-	-	Protein of unknown function (DUF1516)
HIEHEPNM_00555	1.17e-75	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
HIEHEPNM_00556	9.23e-55	-	-	-	-	-	-	-	-
HIEHEPNM_00557	3.38e-169	-	-	-	K	ko:K03489	-	ko00000,ko03000	UTRA
HIEHEPNM_00558	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_00559	0.0	celD	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_00560	3.35e-111	-	-	-	-	-	-	-	-
HIEHEPNM_00561	1.99e-69	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_00562	4.97e-64	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_00563	6.21e-241	ldhD3	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIEHEPNM_00564	6.05e-118	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Methyltransferase
HIEHEPNM_00565	4.14e-155	-	-	-	K	-	-	-	Transcriptional regulatory protein, C terminal
HIEHEPNM_00566	5.65e-255	yclK	-	-	T	-	-	-	Histidine kinase
HIEHEPNM_00567	2.25e-111	-	-	-	-	-	-	-	-
HIEHEPNM_00568	7.29e-290	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_00569	1.05e-143	-	-	-	-	-	-	-	-
HIEHEPNM_00570	1.06e-53	-	-	-	-	-	-	-	-
HIEHEPNM_00571	1.15e-261	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
HIEHEPNM_00572	2.67e-56	-	-	-	-	-	-	-	-
HIEHEPNM_00573	2.16e-265	mccF	-	-	V	-	-	-	LD-carboxypeptidase
HIEHEPNM_00574	2e-238	yveB	-	-	I	-	-	-	PAP2 superfamily
HIEHEPNM_00575	2.48e-142	-	-	-	K	-	-	-	Bacteriophage CI repressor helix-turn-helix domain
HIEHEPNM_00576	3.4e-64	-	-	-	-	-	-	-	-
HIEHEPNM_00577	1.43e-38	-	-	-	-	-	-	-	-
HIEHEPNM_00578	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
HIEHEPNM_00579	3.78e-131	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HIEHEPNM_00580	5.45e-154	yxlF	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_00581	6.52e-36	-	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
HIEHEPNM_00582	1.34e-193	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIEHEPNM_00583	7.11e-260	pmrB	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_00584	4.21e-72	cadC5	-	-	K	ko:K21903	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
HIEHEPNM_00585	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	P-type ATPase
HIEHEPNM_00586	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIEHEPNM_00587	2.94e-264	-	4.1.1.52	-	S	ko:K22213	-	ko00000,ko01000	Amidohydrolase
HIEHEPNM_00588	0.0	ylbB	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00589	9.01e-164	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00590	8.13e-137	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
HIEHEPNM_00591	6.9e-200	yleF	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIEHEPNM_00592	8.98e-253	-	4.2.1.126	-	S	ko:K07106,ko:K09963	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Bacterial protein of unknown function (DUF871)
HIEHEPNM_00593	8.75e-209	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HIEHEPNM_00594	0.0	pts32BC	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_00595	3.05e-282	-	-	-	-	-	-	-	-
HIEHEPNM_00596	3.57e-314	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HIEHEPNM_00597	1.73e-134	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
HIEHEPNM_00598	1.16e-124	-	-	-	-	-	-	-	-
HIEHEPNM_00599	1.96e-98	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00600	4.36e-264	yueF	-	-	S	-	-	-	AI-2E family transporter
HIEHEPNM_00601	1.09e-306	hlyX	-	-	S	ko:K03699	-	ko00000,ko02042	Transporter associated domain
HIEHEPNM_00602	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HIEHEPNM_00603	2.87e-62	XK27_09445	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HIEHEPNM_00604	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
HIEHEPNM_00605	6.69e-39	-	-	-	-	-	-	-	-
HIEHEPNM_00606	1.02e-51	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
HIEHEPNM_00607	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIEHEPNM_00608	2.98e-18	-	-	-	-	-	-	-	-
HIEHEPNM_00609	0.0	iolT	-	-	EGP	ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HIEHEPNM_00611	2.72e-135	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter protein (Thia_YuaJ)
HIEHEPNM_00612	6.02e-104	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HIEHEPNM_00613	5.81e-272	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIEHEPNM_00614	1.9e-171	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
HIEHEPNM_00615	5.52e-55	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIEHEPNM_00616	3.56e-167	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIEHEPNM_00617	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIEHEPNM_00618	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIEHEPNM_00619	6.18e-238	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
HIEHEPNM_00620	9.63e-130	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIEHEPNM_00621	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
HIEHEPNM_00622	1.59e-286	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
HIEHEPNM_00623	1.17e-101	copR	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Copper transport repressor CopY TcrY
HIEHEPNM_00624	0.0	copB	3.6.3.3, 3.6.3.4, 3.6.3.5	-	P	ko:K01533,ko:K01534	-	ko00000,ko01000	P-type ATPase
HIEHEPNM_00625	1.09e-139	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIEHEPNM_00626	1.03e-263	-	-	-	T	ko:K19168	-	ko00000,ko02048	His Kinase A (phosphoacceptor) domain
HIEHEPNM_00627	9.06e-159	rrp1	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
HIEHEPNM_00628	5.63e-178	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_00629	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
HIEHEPNM_00630	9.97e-119	-	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
HIEHEPNM_00631	1.63e-176	yhfI	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
HIEHEPNM_00632	1.8e-86	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HIEHEPNM_00633	9.38e-158	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HIEHEPNM_00634	0.0	glpQ4	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	phosphodiesterase
HIEHEPNM_00635	3.26e-226	pyrD	1.3.5.2, 1.3.98.1	-	F	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dihydroorotate to orotate
HIEHEPNM_00636	1.93e-30	-	-	-	-	-	-	-	-
HIEHEPNM_00637	3.28e-87	-	-	-	-	-	-	-	-
HIEHEPNM_00639	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
HIEHEPNM_00640	2.72e-97	argR1	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HIEHEPNM_00641	1.4e-198	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HIEHEPNM_00642	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HIEHEPNM_00643	3.88e-73	-	-	-	S	-	-	-	Control of competence regulator ComK, YlbF/YmcA
HIEHEPNM_00644	3.57e-233	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIEHEPNM_00645	2.5e-203	prsA	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HIEHEPNM_00646	2.79e-77	-	-	-	S	-	-	-	YtxH-like protein
HIEHEPNM_00647	1.14e-96	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	histidine triad
HIEHEPNM_00648	3.53e-170	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00649	4.2e-284	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_00650	0.000128	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_00651	3.86e-190	ytmP	-	-	M	-	-	-	Choline/ethanolamine kinase
HIEHEPNM_00652	1.11e-154	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HIEHEPNM_00654	4.38e-72	ytpP	-	-	CO	-	-	-	Thioredoxin
HIEHEPNM_00655	1.63e-146	XK27_10290	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HIEHEPNM_00657	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HIEHEPNM_00658	7.57e-34	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HIEHEPNM_00659	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
HIEHEPNM_00660	0.0	XK27_00195	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_00661	0.0	-	-	-	N	-	-	-	domain, Protein
HIEHEPNM_00662	2.02e-174	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_00664	7.54e-242	-	-	-	S	-	-	-	Cell surface protein
HIEHEPNM_00665	1.65e-151	ybhL	-	-	S	ko:K06890	-	ko00000	Inhibitor of apoptosis-promoting Bax1
HIEHEPNM_00666	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIEHEPNM_00667	1.15e-199	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HIEHEPNM_00668	4.88e-133	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HIEHEPNM_00669	3.55e-104	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HIEHEPNM_00670	2.78e-316	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	replication initiation and membrane attachment
HIEHEPNM_00671	3.91e-217	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
HIEHEPNM_00672	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HIEHEPNM_00673	5.87e-86	-	-	-	-	-	-	-	-
HIEHEPNM_00674	1.19e-160	-	-	-	S	-	-	-	SseB protein N-terminal domain
HIEHEPNM_00675	3.94e-45	-	-	-	K	-	-	-	WYL domain
HIEHEPNM_00676	3e-07	-	-	-	-	-	-	-	-
HIEHEPNM_00677	7.83e-292	spoVK	-	-	O	-	-	-	ATPase family associated with various cellular activities (AAA)
HIEHEPNM_00678	2.6e-101	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HIEHEPNM_00679	1.13e-36	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
HIEHEPNM_00680	1.44e-74	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HIEHEPNM_00681	4.79e-129	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
HIEHEPNM_00682	2.91e-229	-	-	-	C	-	-	-	Alcohol dehydrogenase GroES-like domain
HIEHEPNM_00683	8.79e-156	mhqD	-	-	S	ko:K06999	-	ko00000	Dienelactone hydrolase family
HIEHEPNM_00684	1.36e-243	mhqA_2	-	-	E	ko:K15975	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HIEHEPNM_00685	4.06e-213	ykcA	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HIEHEPNM_00686	4.16e-125	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
HIEHEPNM_00687	9.33e-275	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
HIEHEPNM_00688	7.67e-63	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
HIEHEPNM_00689	1.19e-150	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HIEHEPNM_00690	9.21e-142	yqeK	-	-	H	-	-	-	Hydrolase, HD family
HIEHEPNM_00691	1.68e-78	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HIEHEPNM_00692	1.19e-178	yqeM	-	-	Q	-	-	-	Methyltransferase
HIEHEPNM_00693	3.45e-263	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
HIEHEPNM_00694	1.14e-122	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
HIEHEPNM_00695	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HIEHEPNM_00696	1.01e-157	csrR	-	-	K	-	-	-	response regulator
HIEHEPNM_00697	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIEHEPNM_00698	9.37e-230	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIEHEPNM_00699	1.45e-60	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
HIEHEPNM_00700	5e-175	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIEHEPNM_00701	3.09e-122	XK27_09705	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIEHEPNM_00702	1.19e-89	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HIEHEPNM_00703	4.32e-260	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HIEHEPNM_00704	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HIEHEPNM_00705	2.75e-267	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HIEHEPNM_00706	1.98e-147	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
HIEHEPNM_00707	6.1e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HIEHEPNM_00708	2.31e-166	yvqF	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
HIEHEPNM_00709	2.79e-234	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIEHEPNM_00710	3.39e-148	vraR	-	-	K	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
HIEHEPNM_00711	1.91e-70	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
HIEHEPNM_00712	0.0	-	-	-	S	-	-	-	Bacterial membrane protein YfhO
HIEHEPNM_00713	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HIEHEPNM_00714	8.99e-157	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
HIEHEPNM_00715	1.37e-54	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
HIEHEPNM_00716	4.82e-227	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
HIEHEPNM_00717	6.47e-95	yqhL	-	-	P	-	-	-	Rhodanese-like protein
HIEHEPNM_00718	2.75e-34	WQ51_02665	-	-	S	-	-	-	Protein of unknown function (DUF3042)
HIEHEPNM_00719	3.41e-231	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HIEHEPNM_00720	6.73e-305	ynbB	-	-	P	-	-	-	aluminum resistance
HIEHEPNM_00721	0.0	speA	4.1.1.17, 4.1.1.18, 4.1.1.19	-	E	ko:K01581,ko:K01582,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Orn/Lys/Arg decarboxylase, C-terminal domain
HIEHEPNM_00722	5.4e-80	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	Transcriptional regulator
HIEHEPNM_00723	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
HIEHEPNM_00724	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HIEHEPNM_00725	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIEHEPNM_00727	2.69e-297	-	-	-	S	-	-	-	Membrane
HIEHEPNM_00728	1.77e-20	-	-	-	-	-	-	-	-
HIEHEPNM_00729	5.41e-43	-	-	-	-	-	-	-	-
HIEHEPNM_00730	1.18e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
HIEHEPNM_00731	4.18e-73	ysxB	-	-	J	ko:K07584	-	ko00000	Cysteine protease Prp
HIEHEPNM_00732	1.6e-63	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
HIEHEPNM_00733	1.51e-259	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HIEHEPNM_00734	4.27e-132	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIEHEPNM_00735	8.72e-100	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
HIEHEPNM_00736	1.29e-87	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HIEHEPNM_00737	9.8e-197	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HIEHEPNM_00738	2.58e-310	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HIEHEPNM_00739	2.87e-43	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HIEHEPNM_00740	2.27e-186	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HIEHEPNM_00741	4.68e-196	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
HIEHEPNM_00742	3.59e-97	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HIEHEPNM_00743	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
HIEHEPNM_00744	8.07e-68	-	-	-	-	-	-	-	-
HIEHEPNM_00745	4.46e-156	-	-	-	S	ko:K07001	-	ko00000	Patatin-like phospholipase
HIEHEPNM_00746	5.09e-148	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
HIEHEPNM_00747	4.4e-47	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HIEHEPNM_00748	3.8e-273	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIEHEPNM_00749	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIEHEPNM_00750	2.29e-224	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HIEHEPNM_00751	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HIEHEPNM_00752	4.47e-175	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
HIEHEPNM_00753	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HIEHEPNM_00754	2.45e-215	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HIEHEPNM_00755	1.63e-148	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HIEHEPNM_00756	1.1e-158	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
HIEHEPNM_00757	3.26e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
HIEHEPNM_00758	5.83e-75	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HIEHEPNM_00759	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
HIEHEPNM_00760	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIEHEPNM_00761	1.16e-240	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HIEHEPNM_00762	9.22e-49	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIEHEPNM_00763	2.99e-247	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIEHEPNM_00764	5.65e-229	oppF	-	-	P	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIEHEPNM_00765	8.93e-223	oppB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_00766	6.51e-196	oppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIEHEPNM_00767	0.0	oppA1	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIEHEPNM_00768	2.68e-159	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HIEHEPNM_00769	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
HIEHEPNM_00770	7.81e-88	-	-	-	-	-	-	-	-
HIEHEPNM_00771	1.22e-220	ccpB	-	-	K	-	-	-	lacI family
HIEHEPNM_00772	0.0	prtB	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HIEHEPNM_00773	1.62e-199	-	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HIEHEPNM_00774	4.57e-73	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HIEHEPNM_00775	6.19e-109	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HIEHEPNM_00776	7.9e-218	mdtG	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
HIEHEPNM_00777	1.03e-281	yceI	-	-	G	ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
HIEHEPNM_00779	5.25e-238	-	-	-	G	-	-	-	Melibiase
HIEHEPNM_00780	0.0	hylB	4.2.2.1	PL8	N	ko:K01727	-	ko00000,ko01000	Polysaccharide lyase family 8, N terminal alpha-helical domain
HIEHEPNM_00782	2.58e-156	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HIEHEPNM_00783	2.79e-192	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_00784	6.85e-114	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HIEHEPNM_00785	2.15e-175	kduD	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HIEHEPNM_00786	1.8e-181	kduI	5.3.1.17	-	G	ko:K01815	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HIEHEPNM_00787	5.57e-141	-	-	-	K	-	-	-	Bacterial transcriptional regulator
HIEHEPNM_00788	1.8e-131	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_00789	7.7e-258	ugl	3.2.1.180	GH88	S	ko:K18581	-	ko00000,ko01000	Glycosyl Hydrolase Family 88
HIEHEPNM_00790	9.9e-105	-	-	-	G	ko:K02745	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_00791	4.89e-172	-	-	-	G	ko:K02746	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_00792	7.09e-184	agaD	-	-	G	ko:K02747	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HIEHEPNM_00793	1.78e-86	-	-	-	G	ko:K02744	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIEHEPNM_00794	0.000638	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit
HIEHEPNM_00795	0.0	-	-	-	M	-	-	-	Heparinase II/III N-terminus
HIEHEPNM_00796	6.74e-100	-	-	-	-	-	-	-	-
HIEHEPNM_00797	0.0	-	-	-	M	-	-	-	Right handed beta helix region
HIEHEPNM_00798	0.0	-	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_00799	5.54e-156	-	-	-	-	-	-	-	-
HIEHEPNM_00800	4.69e-86	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HIEHEPNM_00801	5.2e-276	adhC	1.1.1.90	-	C	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Zn-dependent alcohol dehydrogenases, class III
HIEHEPNM_00802	4.24e-247	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HIEHEPNM_00803	0.0	iolF	-	-	P	ko:K06610	-	ko00000,ko02000	Sugar (and other) transporter
HIEHEPNM_00804	0.0	rhaB	2.7.1.5	-	F	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
HIEHEPNM_00805	4.22e-74	rhaM	5.1.3.32	-	G	ko:K03534	-	ko00000,ko01000	Involved in the anomeric conversion of L-rhamnose
HIEHEPNM_00806	0.0	rhaA	2.7.1.5, 5.3.1.14	-	G	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	L-rhamnose isomerase (RhaA)
HIEHEPNM_00807	6.22e-211	rhaD	4.1.2.19	-	H	ko:K01629	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
HIEHEPNM_00809	5.58e-156	rdrB	-	-	K	ko:K02444,ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_00810	4.19e-89	pts36A	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_00811	6.21e-68	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_00812	0.0	pts36C	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_00814	1.22e-165	-	4.1.2.17	-	G	ko:K01628	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Class II Aldolase and Adducin N-terminal domain
HIEHEPNM_00815	3.16e-312	-	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Major Facilitator Superfamily
HIEHEPNM_00816	1.95e-94	-	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_00817	1.49e-97	-	-	-	-	-	-	-	-
HIEHEPNM_00818	1.15e-203	-	-	-	K	-	-	-	LysR substrate binding domain
HIEHEPNM_00819	2.69e-310	-	-	-	P	-	-	-	Sodium:sulfate symporter transmembrane region
HIEHEPNM_00820	1.32e-132	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
HIEHEPNM_00821	0.0	yclC	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182,ko:K16874	ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HIEHEPNM_00822	1.56e-189	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HIEHEPNM_00823	2.56e-272	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HIEHEPNM_00824	1.41e-63	gcsH2	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	glycine cleavage
HIEHEPNM_00825	1.35e-283	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
HIEHEPNM_00826	2.92e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
HIEHEPNM_00827	1.62e-72	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
HIEHEPNM_00828	5.48e-35	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
HIEHEPNM_00829	2.13e-230	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
HIEHEPNM_00830	2.5e-43	-	-	-	S	-	-	-	Protein of unknown function (DUF1146)
HIEHEPNM_00831	5.78e-19	-	-	-	-	-	-	-	-
HIEHEPNM_00832	6.51e-83	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
HIEHEPNM_00833	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HIEHEPNM_00835	1.78e-211	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HIEHEPNM_00836	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HIEHEPNM_00837	4.59e-115	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIEHEPNM_00838	8.51e-72	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HIEHEPNM_00839	3.01e-36	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIEHEPNM_00840	4.11e-161	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
HIEHEPNM_00841	8.75e-145	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HIEHEPNM_00842	1.29e-297	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HIEHEPNM_00843	7.03e-246	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HIEHEPNM_00844	1.63e-196	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HIEHEPNM_00845	3.51e-251	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HIEHEPNM_00846	8.22e-144	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
HIEHEPNM_00847	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Domain of unknown function (DUF1727)
HIEHEPNM_00848	2.09e-244	ampC	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_00849	5.54e-210	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
HIEHEPNM_00850	2.49e-179	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
HIEHEPNM_00851	0.0	yfiC	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HIEHEPNM_00852	0.0	ycfI	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00853	5.26e-155	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_00854	3.56e-168	pgm7	-	-	G	-	-	-	Phosphoglycerate mutase family
HIEHEPNM_00859	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIEHEPNM_00860	8e-247	yttB	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_00861	1.56e-25	-	-	-	-	-	-	-	-
HIEHEPNM_00869	4e-110	guaD	-	-	FJ	-	-	-	MafB19-like deaminase
HIEHEPNM_00870	3.12e-220	ysjB	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
HIEHEPNM_00871	6.51e-293	-	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferases group 1
HIEHEPNM_00872	7.92e-102	-	-	-	S	-	-	-	Pfam Transposase IS66
HIEHEPNM_00873	7.26e-183	-	-	-	F	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
HIEHEPNM_00874	7.12e-62	ycnE	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
HIEHEPNM_00876	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
HIEHEPNM_00877	5.43e-195	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
HIEHEPNM_00878	3.74e-142	vanZ	-	-	V	-	-	-	VanZ like family
HIEHEPNM_00879	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HIEHEPNM_00880	1.74e-83	-	-	-	-	-	-	-	-
HIEHEPNM_00881	1.27e-62	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_00883	1.15e-121	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HIEHEPNM_00884	1.96e-224	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
HIEHEPNM_00885	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
HIEHEPNM_00886	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HIEHEPNM_00887	1.21e-257	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HIEHEPNM_00888	6.34e-165	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
HIEHEPNM_00889	1.83e-187	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HIEHEPNM_00890	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_00891	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	(ABC) transporter
HIEHEPNM_00892	1.05e-35	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
HIEHEPNM_00893	1.15e-79	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HIEHEPNM_00894	5.06e-181	-	-	-	-	-	-	-	-
HIEHEPNM_00895	1.54e-222	-	-	-	-	-	-	-	-
HIEHEPNM_00896	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
HIEHEPNM_00897	7.36e-250	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HIEHEPNM_00898	3.66e-229	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
HIEHEPNM_00899	4.19e-212	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
HIEHEPNM_00900	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HIEHEPNM_00901	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
HIEHEPNM_00902	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
HIEHEPNM_00903	8.92e-111	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
HIEHEPNM_00904	3.43e-281	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
HIEHEPNM_00905	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
HIEHEPNM_00906	9.49e-143	dnaD	-	-	L	ko:K02086	-	ko00000	DnaD domain protein
HIEHEPNM_00907	1.9e-147	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIEHEPNM_00908	7.79e-112	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
HIEHEPNM_00909	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
HIEHEPNM_00910	4.21e-156	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HIEHEPNM_00911	1.54e-136	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
HIEHEPNM_00912	5.37e-88	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HIEHEPNM_00914	5.02e-277	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
HIEHEPNM_00915	6.31e-223	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
HIEHEPNM_00916	7.29e-46	-	-	-	-	-	-	-	-
HIEHEPNM_00917	4.08e-248	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
HIEHEPNM_00918	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HIEHEPNM_00919	2.53e-210	lysR	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_00921	2.95e-240	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIEHEPNM_00922	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIEHEPNM_00923	1.76e-51	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
HIEHEPNM_00924	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_00925	4.86e-05	-	-	-	-	-	-	-	-
HIEHEPNM_00926	5.46e-72	-	-	-	-	-	-	-	-
HIEHEPNM_00927	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIEHEPNM_00928	1.72e-142	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
HIEHEPNM_00929	5.59e-90	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HI
HIEHEPNM_00930	5.76e-84	-	-	-	S	-	-	-	Family of unknown function (DUF5322)
HIEHEPNM_00931	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
HIEHEPNM_00932	1.99e-106	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HIEHEPNM_00933	1.74e-222	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HIEHEPNM_00934	3.67e-126	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HIEHEPNM_00935	2.33e-299	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
HIEHEPNM_00936	5.88e-229	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
HIEHEPNM_00937	2.76e-306	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HIEHEPNM_00938	5.32e-267	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HIEHEPNM_00939	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HIEHEPNM_00940	9.32e-194	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HIEHEPNM_00941	1.55e-162	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HIEHEPNM_00942	3.69e-143	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HIEHEPNM_00943	3.31e-246	pfoS/R	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
HIEHEPNM_00944	1.43e-67	-	-	-	S	-	-	-	MazG-like family
HIEHEPNM_00945	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
HIEHEPNM_00947	3.08e-207	-	-	-	S	-	-	-	EDD domain protein, DegV family
HIEHEPNM_00948	3.8e-130	-	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
HIEHEPNM_00949	1.99e-260	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Cys/Met metabolism PLP-dependent enzyme
HIEHEPNM_00950	1.1e-277	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HIEHEPNM_00951	1.34e-139	hisG	2.4.2.17	-	F	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HIEHEPNM_00952	3.62e-287	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIEHEPNM_00953	9.96e-135	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
HIEHEPNM_00954	1.15e-144	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIEHEPNM_00955	1.38e-170	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HIEHEPNM_00956	4.26e-171	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HIEHEPNM_00957	4.81e-76	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIEHEPNM_00958	5.01e-69	hisE	3.6.1.31	-	E	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosyl-ATP diphosphatase activity
HIEHEPNM_00959	4.53e-263	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HIEHEPNM_00960	3.82e-187	yisK	3.7.1.5, 4.1.1.68	-	Q	ko:K05921,ko:K16164	ko00350,ko01100,ko01120,ko01220,map00350,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Fumarylacetoacetate (FAA) hydrolase family
HIEHEPNM_00961	1.76e-145	-	-	-	C	-	-	-	Nitroreductase family
HIEHEPNM_00962	1.22e-93	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00963	7.37e-90	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_00964	2.13e-277	-	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
HIEHEPNM_00965	1.24e-164	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HIEHEPNM_00966	5.58e-221	-	-	-	T	-	-	-	Histidine kinase-like ATPases
HIEHEPNM_00967	5.18e-174	XK27_05695	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_00968	0.0	XK27_05700	-	-	V	ko:K02004,ko:K19084	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	FtsX-like permease family
HIEHEPNM_00969	1.93e-265	xerS	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
HIEHEPNM_00970	3.94e-221	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
HIEHEPNM_00971	1.15e-235	-	-	-	K	-	-	-	LysR substrate binding domain
HIEHEPNM_00972	3.64e-217	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIEHEPNM_00973	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
HIEHEPNM_00974	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HIEHEPNM_00975	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HIEHEPNM_00976	5.92e-142	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HIEHEPNM_00977	4.61e-220	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
HIEHEPNM_00978	0.0	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HIEHEPNM_00979	2.06e-119	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HIEHEPNM_00980	3.34e-214	xerC	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family. XerC subfamily
HIEHEPNM_00981	3.4e-315	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HIEHEPNM_00982	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIEHEPNM_00983	4.65e-189	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
HIEHEPNM_00984	1.61e-175	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIEHEPNM_00985	7.5e-202	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HIEHEPNM_00986	3.27e-167	-	-	-	S	-	-	-	Domain of unknown function (DUF4918)
HIEHEPNM_00987	8.49e-12	-	-	-	-	-	-	-	-
HIEHEPNM_00988	6.03e-55	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_00989	1.23e-306	-	-	-	M	-	-	-	Leucine rich repeats (6 copies)
HIEHEPNM_00990	1.58e-285	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIEHEPNM_00991	5.63e-180	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
HIEHEPNM_00992	9e-191	-	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	NLPA lipoprotein
HIEHEPNM_00995	1.22e-76	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_00996	1.43e-251	ypjH	-	-	C	ko:K08317	-	ko00000,ko01000	dehydrogenase
HIEHEPNM_00999	2.84e-284	amd	-	-	E	-	-	-	Peptidase family M20/M25/M40
HIEHEPNM_01000	1.8e-105	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HIEHEPNM_01001	3.65e-173	-	-	-	S	-	-	-	Putative threonine/serine exporter
HIEHEPNM_01003	6.61e-41	-	-	-	-	-	-	-	-
HIEHEPNM_01004	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIEHEPNM_01005	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HIEHEPNM_01006	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HIEHEPNM_01007	3.01e-177	jag	-	-	S	ko:K06346	-	ko00000	R3H domain protein
HIEHEPNM_01008	8.28e-182	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIEHEPNM_01009	1.56e-78	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HIEHEPNM_01012	3.26e-23	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
HIEHEPNM_01013	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HIEHEPNM_01014	4.16e-260	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HIEHEPNM_01016	2.87e-43	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
HIEHEPNM_01017	3.29e-258	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HIEHEPNM_01018	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIEHEPNM_01019	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIEHEPNM_01020	6.04e-12	-	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
HIEHEPNM_01022	0.0	-	-	-	M	-	-	-	domain protein
HIEHEPNM_01023	3.18e-92	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HIEHEPNM_01024	2.06e-108	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HIEHEPNM_01025	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HIEHEPNM_01026	4.99e-252	-	-	-	K	-	-	-	WYL domain
HIEHEPNM_01027	5.85e-139	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
HIEHEPNM_01028	1.26e-90	psiE	-	-	S	ko:K13256	-	ko00000	Phosphate-starvation-inducible E
HIEHEPNM_01029	1.09e-66	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
HIEHEPNM_01030	1.4e-146	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HIEHEPNM_01031	3.43e-141	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
HIEHEPNM_01032	5.07e-62	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HIEHEPNM_01033	2.07e-200	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HIEHEPNM_01034	5.26e-63	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HIEHEPNM_01035	4.5e-73	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HIEHEPNM_01036	2.92e-153	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HIEHEPNM_01037	1.96e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HIEHEPNM_01038	4.53e-33	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
HIEHEPNM_01039	9.86e-54	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HIEHEPNM_01040	1.73e-77	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HIEHEPNM_01041	1.67e-66	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HIEHEPNM_01042	1.23e-123	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIEHEPNM_01043	1.32e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HIEHEPNM_01044	3.7e-123	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HIEHEPNM_01045	5.63e-77	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HIEHEPNM_01046	8.15e-109	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HIEHEPNM_01047	1.83e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
HIEHEPNM_01048	1.42e-92	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HIEHEPNM_01049	1.63e-297	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HIEHEPNM_01050	3.86e-157	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HIEHEPNM_01051	4.15e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HIEHEPNM_01052	6.38e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
HIEHEPNM_01053	2.66e-76	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIEHEPNM_01054	3.82e-82	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HIEHEPNM_01055	1.8e-218	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIEHEPNM_01056	2.94e-80	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
HIEHEPNM_01057	3.95e-147	-	-	-	-	-	-	-	-
HIEHEPNM_01058	2.32e-197	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIEHEPNM_01059	4.3e-203	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIEHEPNM_01060	5.43e-185	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIEHEPNM_01061	3.99e-178	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HIEHEPNM_01062	3.52e-175	tipA	-	-	K	-	-	-	TipAS antibiotic-recognition domain
HIEHEPNM_01063	1.28e-45	-	-	-	-	-	-	-	-
HIEHEPNM_01064	3.01e-163	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01065	7.16e-236	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HIEHEPNM_01066	2.05e-134	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_01067	4.23e-104	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HIEHEPNM_01068	8.98e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
HIEHEPNM_01069	8.8e-265	-	-	-	EGP	-	-	-	Transmembrane secretion effector
HIEHEPNM_01070	0.0	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
HIEHEPNM_01071	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HIEHEPNM_01073	3.92e-28	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
HIEHEPNM_01075	1.06e-156	-	-	-	S	-	-	-	B3/4 domain
HIEHEPNM_01076	6.12e-190	ssuC	-	-	U	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIEHEPNM_01077	5.81e-155	ssuB	-	-	P	ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01078	5.68e-298	-	-	-	I	-	-	-	Acyltransferase family
HIEHEPNM_01079	0.0	-	6.2.1.48	-	IQ	ko:K02182	-	ko00000,ko01000	AMP-binding enzyme C-terminal domain
HIEHEPNM_01080	2.26e-218	ssuA	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	NMT1-like family
HIEHEPNM_01081	0.0	-	3.2.1.40	-	G	ko:K05989	-	ko00000,ko01000	Bacterial alpha-L-rhamnosidase concanavalin-like domain
HIEHEPNM_01082	0.0	-	-	-	G	ko:K03292,ko:K16210	-	ko00000,ko02000	MFS/sugar transport protein
HIEHEPNM_01083	5.96e-87	crcB1	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HIEHEPNM_01084	3.3e-70	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HIEHEPNM_01086	2.99e-27	-	-	-	-	-	-	-	-
HIEHEPNM_01087	5.73e-209	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HIEHEPNM_01088	7.54e-113	-	-	-	-	-	-	-	-
HIEHEPNM_01089	1.4e-152	-	-	-	GM	-	-	-	NmrA-like family
HIEHEPNM_01090	2.35e-215	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HIEHEPNM_01091	8.32e-56	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIEHEPNM_01092	1.61e-168	mntB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HIEHEPNM_01093	9.44e-186	mtsB	-	-	U	ko:K19972,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
HIEHEPNM_01094	1.55e-224	mntA	-	-	P	ko:K19975,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HIEHEPNM_01095	1.68e-67	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
HIEHEPNM_01096	2.4e-144	-	-	-	P	-	-	-	Cation efflux family
HIEHEPNM_01097	2.5e-34	-	-	-	-	-	-	-	-
HIEHEPNM_01098	0.0	sufI	-	-	Q	-	-	-	Multicopper oxidase
HIEHEPNM_01099	1.61e-288	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_01100	4.42e-84	-	-	-	-	-	-	-	-
HIEHEPNM_01101	0.0	atp2C1	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HIEHEPNM_01102	0.0	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HIEHEPNM_01103	7.48e-25	-	-	-	-	-	-	-	-
HIEHEPNM_01104	2.58e-171	-	-	-	-	-	-	-	-
HIEHEPNM_01105	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HIEHEPNM_01106	5.39e-32	-	-	-	S	-	-	-	Short C-terminal domain
HIEHEPNM_01107	1.61e-274	yqiG	-	-	C	-	-	-	Oxidoreductase
HIEHEPNM_01108	1.81e-168	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HIEHEPNM_01109	3.98e-229	ydhF	-	-	S	-	-	-	Aldo keto reductase
HIEHEPNM_01110	1.59e-71	-	-	-	S	-	-	-	Enterocin A Immunity
HIEHEPNM_01111	1.05e-70	-	-	-	-	-	-	-	-
HIEHEPNM_01112	0.0	norB	-	-	EGP	ko:K08170	-	ko00000,ko00002,ko01504,ko02000	Major Facilitator Superfamily
HIEHEPNM_01113	2.35e-91	-	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_01114	8.4e-170	-	-	-	S	-	-	-	CAAX protease self-immunity
HIEHEPNM_01118	1.59e-30	-	-	-	-	-	-	-	-
HIEHEPNM_01119	1.3e-59	-	-	-	S	-	-	-	Enterocin A Immunity
HIEHEPNM_01120	1.58e-170	plnD	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HIEHEPNM_01121	5.99e-287	comD	2.7.13.3	-	T	ko:K07706,ko:K12294	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	ATPase histidine kinase DNA gyrase B HSP90 domain protein
HIEHEPNM_01123	4.66e-110	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_01124	1.72e-208	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_01125	1.14e-107	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_01126	5.9e-15	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_01127	4.39e-06	-	-	-	-	-	-	-	-
HIEHEPNM_01128	2.24e-72	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
HIEHEPNM_01129	1.63e-103	yphH	-	-	S	-	-	-	Cupin domain
HIEHEPNM_01130	1.2e-207	-	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_01131	8.81e-166	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIEHEPNM_01132	4.56e-215	bcrA	-	-	V	ko:K01990,ko:K19309	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HIEHEPNM_01133	1.38e-153	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HIEHEPNM_01134	1.15e-204	-	-	-	T	-	-	-	GHKL domain
HIEHEPNM_01135	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIEHEPNM_01136	9.53e-202	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphatase and related hydrolases of the PHP family
HIEHEPNM_01137	3.98e-171	-	-	-	F	-	-	-	deoxynucleoside kinase
HIEHEPNM_01138	1.02e-178	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
HIEHEPNM_01139	5.95e-212	-	-	-	IQ	-	-	-	NAD dependent epimerase/dehydratase family
HIEHEPNM_01140	1.4e-198	mrsA1	1.8.4.11	-	O	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIEHEPNM_01141	2.9e-158	-	-	-	G	-	-	-	Phosphoglycerate mutase family
HIEHEPNM_01142	1.01e-192	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
HIEHEPNM_01143	2.93e-158	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
HIEHEPNM_01144	4.72e-141	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
HIEHEPNM_01145	1.63e-95	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HIEHEPNM_01146	0.0	-	6.3.2.2	-	M	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Mur ligase middle domain protein
HIEHEPNM_01147	1.84e-302	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HIEHEPNM_01148	1.41e-53	-	-	-	-	-	-	-	-
HIEHEPNM_01149	6.47e-110	uspA	-	-	T	-	-	-	universal stress protein
HIEHEPNM_01150	2.16e-206	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIEHEPNM_01151	3.54e-230	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
HIEHEPNM_01152	8.1e-87	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HIEHEPNM_01153	2.14e-36	-	-	-	-	-	-	-	-
HIEHEPNM_01155	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
HIEHEPNM_01156	1.42e-102	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
HIEHEPNM_01157	1.39e-281	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIEHEPNM_01158	1.21e-243	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
HIEHEPNM_01159	2.4e-183	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
HIEHEPNM_01160	5.58e-151	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_01161	9.88e-236	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIEHEPNM_01162	8.69e-192	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HIEHEPNM_01163	9.5e-209	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_01164	9.89e-243	-	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium Transporter Family
HIEHEPNM_01165	1.37e-269	-	-	-	P	-	-	-	Pyridine nucleotide-disulphide oxidoreductase
HIEHEPNM_01166	3.23e-204	p40	-	-	D	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain
HIEHEPNM_01167	0.0	ylbB	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_01168	3.54e-165	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01169	6.57e-125	-	-	-	K	-	-	-	transcriptional regulator
HIEHEPNM_01170	2.94e-195	-	-	-	G	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIEHEPNM_01171	2.32e-60	-	-	-	-	-	-	-	-
HIEHEPNM_01172	1.29e-163	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HIEHEPNM_01173	8.48e-134	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HIEHEPNM_01174	1.86e-146	lacA	2.3.1.18, 2.3.1.79	-	S	ko:K00633,ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
HIEHEPNM_01175	7.34e-72	-	-	-	-	-	-	-	-
HIEHEPNM_01177	0.0	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIEHEPNM_01178	1.7e-142	-	-	-	S	-	-	-	Membrane
HIEHEPNM_01179	3.12e-111	-	-	-	-	-	-	-	-
HIEHEPNM_01180	5.38e-68	-	-	-	-	-	-	-	-
HIEHEPNM_01182	1.32e-300	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HIEHEPNM_01183	3.24e-158	azlC	-	-	E	-	-	-	branched-chain amino acid
HIEHEPNM_01184	1.29e-66	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
HIEHEPNM_01185	0.0	-	3.2.1.31	-	G	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 2 family
HIEHEPNM_01186	0.0	-	-	-	M	-	-	-	Glycosyl hydrolase family 59
HIEHEPNM_01187	5.06e-152	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HIEHEPNM_01188	6.08e-227	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_01189	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
HIEHEPNM_01190	4.1e-276	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
HIEHEPNM_01191	0.0	uxuB	1.1.1.57	-	G	ko:K00040	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Mannitol dehydrogenase C-terminal domain
HIEHEPNM_01192	0.0	-	3.2.1.45	GH30	G	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	ko00000,ko00001,ko01000	Glycosyl hydrolase family 30 TIM-barrel domain
HIEHEPNM_01193	6.58e-293	-	-	-	G	-	-	-	Major Facilitator
HIEHEPNM_01194	1.9e-163	kdgR	-	-	K	-	-	-	FCD domain
HIEHEPNM_01195	1.74e-242	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_01196	0.0	-	-	-	M	-	-	-	Glycosyl hydrolase family 59
HIEHEPNM_01197	9.4e-76	ps105	-	-	-	-	-	-	-
HIEHEPNM_01198	3.77e-85	-	-	-	S	-	-	-	pyridoxamine 5-phosphate
HIEHEPNM_01199	1e-306	-	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_01200	2.81e-279	-	3.1.1.83	-	I	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	ko00000,ko00001,ko01000	Alpha beta hydrolase
HIEHEPNM_01201	6.4e-60	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_01202	4.49e-187	ptp3	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HIEHEPNM_01203	5.06e-282	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Domain of unknown function (DUF1730)
HIEHEPNM_01204	2.11e-82	-	-	-	-	-	-	-	-
HIEHEPNM_01205	2.46e-114	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
HIEHEPNM_01207	1.05e-131	-	-	-	Q	-	-	-	methyltransferase
HIEHEPNM_01208	3.75e-142	-	-	-	T	-	-	-	Sh3 type 3 domain protein
HIEHEPNM_01209	1.71e-145	-	-	-	F	-	-	-	glutamine amidotransferase
HIEHEPNM_01210	1.82e-175	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2263)
HIEHEPNM_01211	0.0	yhdP	-	-	S	-	-	-	Transporter associated domain
HIEHEPNM_01212	2.21e-184	-	-	-	S	-	-	-	Alpha beta hydrolase
HIEHEPNM_01213	3.95e-253	-	-	-	I	-	-	-	Acyltransferase
HIEHEPNM_01214	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HIEHEPNM_01215	9.24e-109	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HIEHEPNM_01216	1.43e-123	maf	-	-	D	ko:K06287	-	ko00000	nucleoside-triphosphate diphosphatase activity
HIEHEPNM_01217	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HIEHEPNM_01218	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HIEHEPNM_01219	0.0	ydaO	-	-	E	-	-	-	amino acid
HIEHEPNM_01220	7.56e-75	-	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HIEHEPNM_01221	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HIEHEPNM_01222	1.7e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HIEHEPNM_01223	1.23e-142	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIEHEPNM_01224	4.11e-251	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIEHEPNM_01225	3.97e-235	-	-	-	-	-	-	-	-
HIEHEPNM_01226	4e-202	-	-	-	V	ko:K01990,ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01227	7.06e-81	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
HIEHEPNM_01228	7.76e-152	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HIEHEPNM_01229	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
HIEHEPNM_01230	6.92e-66	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_01231	4.36e-240	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HIEHEPNM_01232	1.06e-127	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
HIEHEPNM_01233	3.82e-168	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
HIEHEPNM_01234	7.32e-153	-	-	-	-	-	-	-	-
HIEHEPNM_01235	4.02e-116	-	-	-	T	-	-	-	ECF transporter, substrate-specific component
HIEHEPNM_01236	8.71e-232	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	Asparaginase
HIEHEPNM_01237	4.51e-184	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
HIEHEPNM_01238	1.56e-194	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HIEHEPNM_01239	2.27e-75	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
HIEHEPNM_01240	2.38e-225	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HIEHEPNM_01241	2.31e-69	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
HIEHEPNM_01242	2.6e-149	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HIEHEPNM_01243	1.35e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
HIEHEPNM_01244	2.17e-140	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIEHEPNM_01245	2.29e-50	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HIEHEPNM_01246	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIEHEPNM_01247	5.13e-113	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HIEHEPNM_01248	5.69e-65	-	-	-	-	-	-	-	-
HIEHEPNM_01249	3.34e-139	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
HIEHEPNM_01250	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HIEHEPNM_01251	2.27e-89	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIEHEPNM_01252	2.84e-215	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
HIEHEPNM_01253	5.01e-142	-	-	-	-	-	-	-	-
HIEHEPNM_01254	4.96e-219	yfdH	-	GT2	M	ko:K12999	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HIEHEPNM_01255	3.76e-107	-	-	-	S	-	-	-	Fic/DOC family
HIEHEPNM_01256	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HIEHEPNM_01257	0.0	-	-	-	S	-	-	-	Bacterial membrane protein YfhO
HIEHEPNM_01258	0.0	bglH	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_01259	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_01260	1.09e-270	secA2	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HIEHEPNM_01261	1.06e-39	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
HIEHEPNM_01262	2.08e-58	-	-	-	M	-	-	-	Glycosyl transferase family 8
HIEHEPNM_01263	3.8e-150	-	-	-	M	-	-	-	lipopolysaccharide 3-alpha-galactosyltransferase activity
HIEHEPNM_01264	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HIEHEPNM_01265	3.87e-301	mesE	-	-	M	ko:K12293,ko:K20345	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	Transport protein ComB
HIEHEPNM_01266	5.9e-78	-	-	-	-	-	-	-	-
HIEHEPNM_01267	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
HIEHEPNM_01268	1.07e-237	tas	-	-	C	-	-	-	Aldo/keto reductase family
HIEHEPNM_01269	1.23e-58	-	-	-	S	-	-	-	Enterocin A Immunity
HIEHEPNM_01270	1.93e-170	-	-	-	-	-	-	-	-
HIEHEPNM_01271	5.59e-176	-	-	-	-	-	-	-	-
HIEHEPNM_01272	5.62e-75	padR	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HIEHEPNM_01273	9.02e-125	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIEHEPNM_01274	4.88e-263	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
HIEHEPNM_01275	4.38e-285	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
HIEHEPNM_01276	4.45e-133	-	-	-	-	-	-	-	-
HIEHEPNM_01277	0.0	-	-	-	M	-	-	-	domain protein
HIEHEPNM_01278	0.0	-	-	-	M	-	-	-	domain protein
HIEHEPNM_01279	0.0	-	-	-	M	-	-	-	Cna protein B-type domain
HIEHEPNM_01280	9.3e-172	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HIEHEPNM_01282	6.62e-69	salX	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01283	3.66e-36	-	-	-	V	-	-	-	MacB-like periplasmic core domain
HIEHEPNM_01284	3.96e-120	-	-	-	-	-	-	-	-
HIEHEPNM_01286	1.38e-189	proB	2.7.2.11	-	F	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HIEHEPNM_01287	5.56e-287	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HIEHEPNM_01288	4.93e-286	-	-	-	EGP	-	-	-	Transmembrane secretion effector
HIEHEPNM_01289	1.11e-44	-	-	-	-	-	-	-	-
HIEHEPNM_01290	2.13e-44	-	-	-	-	-	-	-	-
HIEHEPNM_01292	9.32e-118	-	-	-	KT	ko:K02647	-	ko00000,ko03000	Purine catabolism regulatory protein-like family
HIEHEPNM_01293	3.92e-218	-	-	-	EGP	ko:K08196	-	ko00000,ko02000	Major Facilitator
HIEHEPNM_01294	4.06e-146	udp	2.4.2.3	-	F	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Phosphorylase superfamily
HIEHEPNM_01295	3.49e-242	-	-	-	EGP	ko:K08196	-	ko00000,ko02000	Major Facilitator
HIEHEPNM_01296	9.56e-189	-	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HIEHEPNM_01297	9.49e-26	-	-	-	S	-	-	-	CsbD-like
HIEHEPNM_01298	2.43e-264	lctO	1.13.12.4	-	C	ko:K00467,ko:K10530	ko00620,map00620	ko00000,ko00001,ko01000	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
HIEHEPNM_01299	5.45e-61	-	-	-	-	-	-	-	-
HIEHEPNM_01300	1.1e-256	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HIEHEPNM_01301	9.8e-158	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIEHEPNM_01302	2.36e-119	ccpN	-	-	K	-	-	-	Domain in cystathionine beta-synthase and other proteins.
HIEHEPNM_01303	0.0	ppdK	2.7.9.1	-	G	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the PEP-utilizing enzyme family
HIEHEPNM_01304	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
HIEHEPNM_01305	2.55e-212	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01306	7.65e-272	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIEHEPNM_01307	1.42e-249	-	-	-	-	-	-	-	-
HIEHEPNM_01308	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
HIEHEPNM_01309	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
HIEHEPNM_01310	2.37e-65	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
HIEHEPNM_01311	4.49e-130	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTPase
HIEHEPNM_01312	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HIEHEPNM_01313	1.06e-258	yacL	-	-	S	-	-	-	domain protein
HIEHEPNM_01314	1.12e-138	-	-	-	K	-	-	-	sequence-specific DNA binding
HIEHEPNM_01315	9.79e-121	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01316	6.42e-88	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIEHEPNM_01317	6.07e-292	inlJ	-	-	M	-	-	-	MucBP domain
HIEHEPNM_01318	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_01319	3.54e-82	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
HIEHEPNM_01320	4.58e-225	-	-	-	S	-	-	-	Membrane
HIEHEPNM_01321	1.36e-179	yhfC	-	-	S	-	-	-	Putative membrane peptidase family (DUF2324)
HIEHEPNM_01322	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIEHEPNM_01324	5.16e-127	-	-	-	-	-	-	-	-
HIEHEPNM_01325	4.31e-312	loxD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
HIEHEPNM_01326	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HIEHEPNM_01327	2.3e-96	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HIEHEPNM_01328	2.6e-185	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIEHEPNM_01329	1.45e-126	yacP	-	-	S	ko:K06962	-	ko00000	YacP-like NYN domain
HIEHEPNM_01330	3.64e-249	XK27_00915	-	-	C	-	-	-	Luciferase-like monooxygenase
HIEHEPNM_01331	2.58e-155	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	Rossmann-like domain
HIEHEPNM_01332	4.05e-247	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HIEHEPNM_01333	2.02e-273	-	-	-	-	-	-	-	-
HIEHEPNM_01334	3.67e-196	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01335	1.29e-202	-	-	-	-	-	-	-	-
HIEHEPNM_01336	5.81e-125	-	-	-	-	-	-	-	-
HIEHEPNM_01337	3.41e-187	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HIEHEPNM_01338	9.18e-105	-	-	-	-	-	-	-	-
HIEHEPNM_01339	9.42e-232	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HIEHEPNM_01340	7.23e-128	hepA	2.5.1.30	-	S	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase component I
HIEHEPNM_01341	2.87e-106	-	-	-	S	-	-	-	NusG domain II
HIEHEPNM_01342	1.06e-166	ndh	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HIEHEPNM_01343	2.6e-150	-	-	-	S	ko:K07118	-	ko00000	NmrA-like family
HIEHEPNM_01345	8.01e-254	-	-	-	-	-	-	-	-
HIEHEPNM_01346	3.18e-195	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HIEHEPNM_01347	1.34e-115	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HIEHEPNM_01349	1.22e-155	yrkL	-	-	S	-	-	-	Flavodoxin-like fold
HIEHEPNM_01350	5.27e-191	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HIEHEPNM_01351	3.38e-266	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific adenine glycosylase
HIEHEPNM_01352	5.22e-112	hsp1	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HIEHEPNM_01353	2.94e-14	-	-	-	-	-	-	-	-
HIEHEPNM_01354	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	Putative exonuclease SbcCD, C subunit
HIEHEPNM_01355	4.96e-270	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HIEHEPNM_01356	2.07e-147	-	-	-	S	-	-	-	HAD hydrolase, family IA, variant
HIEHEPNM_01357	2.49e-182	-	-	-	K	ko:K02530	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_01358	6.59e-96	lacA	5.3.1.26	-	G	ko:K01819	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Ribose/Galactose Isomerase
HIEHEPNM_01359	1.85e-121	lacB	5.3.1.26	-	G	ko:K01819	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Ribose/Galactose Isomerase
HIEHEPNM_01360	0.0	XK27_09600	-	-	V	ko:K06147,ko:K18891	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01361	0.0	-	-	-	V	ko:K06147,ko:K18892	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01362	2.07e-281	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	Major Facilitator Superfamily
HIEHEPNM_01363	3.66e-165	treR	-	-	K	ko:K03486	-	ko00000,ko03000	UTRA
HIEHEPNM_01364	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_01365	0.0	treB	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_01366	4.39e-273	sstT	-	-	U	ko:K07862	-	ko00000,ko02000	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HIEHEPNM_01367	0.0	-	-	-	E	ko:K03294	-	ko00000	Amino Acid
HIEHEPNM_01368	3.78e-220	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	lactate/malate dehydrogenase, alpha/beta C-terminal domain
HIEHEPNM_01369	1.19e-314	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
HIEHEPNM_01370	3.08e-43	cspA	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
HIEHEPNM_01371	3.02e-92	-	-	-	-	-	-	-	-
HIEHEPNM_01372	1.95e-99	-	-	-	O	-	-	-	OsmC-like protein
HIEHEPNM_01373	0.0	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
HIEHEPNM_01374	1.11e-146	ylbE	-	-	GM	-	-	-	NAD(P)H-binding
HIEHEPNM_01375	1.02e-203	-	-	-	S	-	-	-	Aldo/keto reductase family
HIEHEPNM_01376	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HIEHEPNM_01377	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3800)
HIEHEPNM_01378	0.0	nhaK	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HIEHEPNM_01379	7.8e-78	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
HIEHEPNM_01380	1.51e-89	-	-	-	K	-	-	-	LytTr DNA-binding domain
HIEHEPNM_01381	5.16e-190	-	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
HIEHEPNM_01382	7.73e-201	-	-	-	V	ko:K01990,ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01383	5.46e-187	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HIEHEPNM_01384	3.41e-144	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	Eukaryotic-type carbonic anhydrase
HIEHEPNM_01385	1.06e-69	ybjQ	-	-	S	-	-	-	Belongs to the UPF0145 family
HIEHEPNM_01386	1.72e-120	-	3.6.1.22	-	L	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	ko00000,ko00001,ko01000	NUDIX domain
HIEHEPNM_01387	1.23e-200	-	-	-	C	-	-	-	nadph quinone reductase
HIEHEPNM_01388	1.09e-310	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
HIEHEPNM_01389	1.62e-226	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Peroxidase
HIEHEPNM_01390	3.15e-153	yqgG	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
HIEHEPNM_01391	2.15e-195	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
HIEHEPNM_01393	2.68e-15	-	-	-	-	-	-	-	-
HIEHEPNM_01394	0.0	ykpA	-	-	S	-	-	-	ABC transporter, ATP-binding protein
HIEHEPNM_01395	0.0	-	-	-	L	-	-	-	ATPase domain of DNA mismatch repair MUTS family
HIEHEPNM_01396	8.94e-146	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
HIEHEPNM_01397	8.08e-172	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HIEHEPNM_01398	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
HIEHEPNM_01399	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIEHEPNM_01400	1.76e-174	epsG	-	-	M	-	-	-	Glycosyltransferase like family 2
HIEHEPNM_01401	5.46e-178	lacT	-	-	K	ko:K02531	-	ko00000,ko03000	PRD domain
HIEHEPNM_01402	0.0	lacE	2.7.1.207	-	G	ko:K02787,ko:K02788	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase system, EIIC
HIEHEPNM_01403	1.33e-311	lacG	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_01404	8.62e-66	lacF	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_01406	2.83e-283	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HIEHEPNM_01407	1.04e-247	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIEHEPNM_01408	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
HIEHEPNM_01409	5.88e-213	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HIEHEPNM_01410	5.59e-250	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
HIEHEPNM_01412	4.46e-91	-	2.7.1.204	-	G	ko:K20112	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01413	2.13e-64	-	2.7.1.204	-	G	ko:K20113	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_01414	0.0	gatC	-	-	G	ko:K20114	ko02060,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_01416	1.91e-38	-	-	-	-	-	-	-	-
HIEHEPNM_01417	8.15e-241	-	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_01418	3.84e-161	-	-	-	S	-	-	-	Domain of unknown function (DUF4867)
HIEHEPNM_01419	1.43e-224	lacC	2.7.1.144	-	H	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_01420	4.82e-184	srlD	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	NAD dependent epimerase/dehydratase family
HIEHEPNM_01421	0.0	srlM	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HIEHEPNM_01422	2.53e-113	srlM1	-	-	K	-	-	-	Glucitol operon activator protein (GutM)
HIEHEPNM_01423	1.43e-131	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
HIEHEPNM_01424	1.88e-252	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Sorbitol phosphotransferase enzyme II N-terminus
HIEHEPNM_01425	1.74e-82	-	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
HIEHEPNM_01426	2.41e-158	-	-	-	H	-	-	-	Pfam:Transaldolase
HIEHEPNM_01427	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_01428	1.33e-70	-	-	-	S	-	-	-	PRD domain
HIEHEPNM_01429	1.23e-80	-	-	-	S	-	-	-	Glycine-rich SFCGS
HIEHEPNM_01430	6.76e-75	-	-	-	S	-	-	-	Domain of unknown function (DUF4312)
HIEHEPNM_01431	2.89e-177	-	-	-	S	-	-	-	Domain of unknown function (DUF4311)
HIEHEPNM_01432	1.94e-152	-	-	-	S	-	-	-	Domain of unknown function (DUF4310)
HIEHEPNM_01433	3.01e-275	dho	3.5.2.3	-	S	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase family
HIEHEPNM_01434	3.41e-257	selA	2.9.1.1	-	H	ko:K01042	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko01000	L-seryl-tRNA selenium transferase
HIEHEPNM_01435	1.96e-177	-	4.1.2.14	-	S	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	ko00000,ko00001,ko00002,ko01000	KDGP aldolase
HIEHEPNM_01437	7.71e-259	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HIEHEPNM_01438	6.45e-41	-	-	-	-	-	-	-	-
HIEHEPNM_01439	3.43e-82	hol	-	-	S	-	-	-	Bacteriophage holin
HIEHEPNM_01440	2.09e-63	-	-	-	-	-	-	-	-
HIEHEPNM_01441	2.47e-61	-	-	-	M	-	-	-	CotH kinase protein
HIEHEPNM_01442	6.46e-53	-	-	-	M	-	-	-	Prophage endopeptidase tail
HIEHEPNM_01443	4.82e-51	-	-	-	S	-	-	-	phage tail
HIEHEPNM_01444	0.0	-	-	-	S	-	-	-	peptidoglycan catabolic process
HIEHEPNM_01445	2.72e-27	-	-	-	-	-	-	-	-
HIEHEPNM_01446	1.91e-95	-	-	-	S	-	-	-	Pfam:Phage_TTP_1
HIEHEPNM_01447	3.76e-38	-	-	-	-	-	-	-	-
HIEHEPNM_01448	1.62e-87	-	-	-	S	-	-	-	exonuclease activity
HIEHEPNM_01449	9.69e-53	-	-	-	S	-	-	-	Phage head-tail joining protein
HIEHEPNM_01450	3.59e-35	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HIEHEPNM_01451	2.4e-37	-	-	-	S	-	-	-	peptidase activity
HIEHEPNM_01452	1.71e-263	-	-	-	S	-	-	-	peptidase activity
HIEHEPNM_01453	3.52e-135	-	-	-	S	-	-	-	peptidase activity
HIEHEPNM_01454	4.22e-286	-	-	-	S	-	-	-	Phage portal protein
HIEHEPNM_01456	0.0	-	-	-	S	-	-	-	Phage Terminase
HIEHEPNM_01457	2.95e-101	-	-	-	S	-	-	-	Phage terminase, small subunit
HIEHEPNM_01458	4.14e-90	-	-	-	S	-	-	-	HNH endonuclease
HIEHEPNM_01459	3.63e-67	-	-	-	-	-	-	-	-
HIEHEPNM_01460	9.45e-126	-	-	-	S	-	-	-	HNH endonuclease
HIEHEPNM_01461	1.57e-300	-	-	-	-	-	-	-	-
HIEHEPNM_01463	1.55e-101	-	-	-	-	-	-	-	-
HIEHEPNM_01465	4.83e-45	-	-	-	-	-	-	-	-
HIEHEPNM_01467	3.21e-120	-	-	-	S	-	-	-	Protein of unknown function (DUF1642)
HIEHEPNM_01468	3.26e-36	-	-	-	-	-	-	-	-
HIEHEPNM_01469	1.59e-34	-	-	-	-	-	-	-	-
HIEHEPNM_01470	2.27e-86	-	-	-	S	-	-	-	magnesium ion binding
HIEHEPNM_01471	1.88e-52	-	-	-	-	-	-	-	-
HIEHEPNM_01474	3.14e-294	-	-	-	S	-	-	-	DNA helicase activity
HIEHEPNM_01475	1.25e-137	-	-	-	S	-	-	-	calcium ion binding
HIEHEPNM_01482	2.04e-106	-	-	-	S	-	-	-	Phage regulatory protein Rha (Phage_pRha)
HIEHEPNM_01483	2.51e-40	-	-	-	K	ko:K07741	-	ko00000	BRO family, N-terminal domain
HIEHEPNM_01485	3.44e-48	-	-	-	K	-	-	-	Helix-turn-helix
HIEHEPNM_01486	1.4e-24	-	-	-	K	-	-	-	Peptidase S24-like
HIEHEPNM_01487	4.33e-121	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HIEHEPNM_01488	9.91e-28	-	-	-	-	-	-	-	-
HIEHEPNM_01490	1.13e-271	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIEHEPNM_01493	0.0	-	-	-	L	-	-	-	DNA helicase
HIEHEPNM_01494	4.46e-189	rlrG	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
HIEHEPNM_01495	2.03e-225	ydiA	-	-	P	ko:K11041	ko05150,map05150	ko00000,ko00001,ko02042	Voltage-dependent anion channel
HIEHEPNM_01496	5.4e-175	yadH	-	-	V	ko:K01992,ko:K09694	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
HIEHEPNM_01497	1.22e-170	cylA	-	-	V	ko:K01990,ko:K09695,ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01498	9.8e-167	ydfF	-	-	K	-	-	-	Transcriptional
HIEHEPNM_01499	6.32e-141	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIEHEPNM_01501	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIEHEPNM_01502	1.13e-138	yagB	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIEHEPNM_01503	4.69e-94	-	-	-	K	-	-	-	MarR family
HIEHEPNM_01504	0.0	uvrA3	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC
HIEHEPNM_01505	9.22e-246	yghZ	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo keto reductase family protein
HIEHEPNM_01506	5.39e-183	-	-	-	S	-	-	-	hydrolase
HIEHEPNM_01507	3.33e-78	-	-	-	-	-	-	-	-
HIEHEPNM_01508	1.71e-17	-	-	-	-	-	-	-	-
HIEHEPNM_01509	2.65e-149	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
HIEHEPNM_01510	3.55e-163	gpmB	-	-	G	ko:K15640	-	ko00000	Phosphoglycerate mutase family
HIEHEPNM_01511	4.01e-194	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
HIEHEPNM_01512	1.38e-117	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIEHEPNM_01513	2.17e-213	-	-	-	K	-	-	-	LysR substrate binding domain
HIEHEPNM_01514	4.76e-288	-	-	-	EK	-	-	-	Aminotransferase, class I
HIEHEPNM_01516	3.7e-60	-	-	-	-	-	-	-	-
HIEHEPNM_01517	5.18e-75	-	-	-	-	-	-	-	-
HIEHEPNM_01518	3.1e-254	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HIEHEPNM_01519	5.11e-149	ydfK	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
HIEHEPNM_01520	4.31e-115	-	-	-	-	-	-	-	-
HIEHEPNM_01522	0.0	fruC	2.7.1.202	-	GT	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01523	1.94e-216	fruK-1	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_01524	2.02e-168	rpl	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIEHEPNM_01525	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIEHEPNM_01527	1.49e-164	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01528	5.73e-82	lexA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator, GntR family
HIEHEPNM_01529	6.17e-203	-	-	-	S	-	-	-	Alpha beta hydrolase
HIEHEPNM_01530	2.15e-237	-	-	-	K	-	-	-	Helix-turn-helix domain
HIEHEPNM_01531	6.02e-163	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HIEHEPNM_01532	0.0	ypiB	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_01533	9.85e-147	-	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
HIEHEPNM_01534	0.0	-	-	-	M	ko:K01992	-	ko00000,ko00002,ko02000	Exporter of polyketide antibiotics
HIEHEPNM_01535	5.54e-214	ybhF_1	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_01536	5e-174	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
HIEHEPNM_01537	4.82e-83	ORF00048	-	-	-	-	-	-	-
HIEHEPNM_01538	7.63e-74	padR	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HIEHEPNM_01539	1.29e-135	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
HIEHEPNM_01540	1.36e-112	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_01541	2.75e-123	kptA	-	-	J	ko:K07559	-	ko00000,ko01000,ko03016	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HIEHEPNM_01542	4.38e-56	-	-	-	-	-	-	-	-
HIEHEPNM_01543	2.47e-308	citM	-	-	C	ko:K03300	-	ko00000	Citrate transporter
HIEHEPNM_01544	5.72e-69	-	-	-	-	-	-	-	-
HIEHEPNM_01545	1.44e-57	oadG	-	-	I	-	-	-	Biotin-requiring enzyme
HIEHEPNM_01546	1.6e-250	oadB	4.1.1.3	-	C	ko:K01572	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Na+-transporting oxaloacetate decarboxylase beta subunit
HIEHEPNM_01547	4.63e-07	-	-	-	-	-	-	-	-
HIEHEPNM_01548	4.66e-232	citC	6.2.1.22	-	H	ko:K01910	ko02020,map02020	ko00000,ko00001,ko01000	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HIEHEPNM_01549	4.85e-65	citD	-	-	C	ko:K01646	ko02020,map02020	ko00000,ko00001	Covalent carrier of the coenzyme of citrate lyase
HIEHEPNM_01550	2.5e-199	citE	4.1.3.34	-	G	ko:K01644	ko02020,map02020	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
HIEHEPNM_01551	0.0	citF	2.8.3.10	-	H	ko:K01643	ko02020,map02020	ko00000,ko00001,ko01000	Citrate (pro-3S)-lyase alpha chain
HIEHEPNM_01552	4.83e-131	citX	2.7.7.61	-	HI	ko:K05964	ko02020,map02020	ko00000,ko00001,ko01000	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HIEHEPNM_01553	0.0	oadA	4.1.1.3	-	C	ko:K01571	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Conserved carboxylase domain
HIEHEPNM_01554	6.87e-162	citR	-	-	K	-	-	-	FCD
HIEHEPNM_01555	2.83e-202	citG	2.4.2.52	-	H	ko:K05966	ko02020,map02020	ko00000,ko00001,ko01000	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HIEHEPNM_01556	4.44e-62	-	-	-	-	-	-	-	-
HIEHEPNM_01557	1.37e-90	-	-	-	-	-	-	-	-
HIEHEPNM_01558	1.92e-83	-	-	-	-	-	-	-	-
HIEHEPNM_01559	1.2e-199	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HIEHEPNM_01560	3.21e-204	yjbO	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HIEHEPNM_01561	1.43e-25	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HIEHEPNM_01562	1.42e-132	-	-	-	-	-	-	-	-
HIEHEPNM_01563	9.53e-241	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF916)
HIEHEPNM_01564	2.4e-07	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_01565	1.69e-125	yjcK	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HIEHEPNM_01566	1.96e-126	-	-	-	-	-	-	-	-
HIEHEPNM_01567	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HIEHEPNM_01568	1.97e-168	budA	4.1.1.5	-	Q	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
HIEHEPNM_01570	0.0	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
HIEHEPNM_01571	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_01572	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_01573	4.36e-284	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HIEHEPNM_01576	1.07e-238	-	-	-	-	-	-	-	-
HIEHEPNM_01577	5.46e-189	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	N-formylglutamate amidohydrolase
HIEHEPNM_01578	8.85e-72	XK27_08430	-	-	S	-	-	-	Staphylococcal protein of unknown function (DUF960)
HIEHEPNM_01579	2.18e-117	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIEHEPNM_01580	4.87e-123	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HIEHEPNM_01581	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HIEHEPNM_01582	2.01e-81	-	-	-	-	-	-	-	-
HIEHEPNM_01583	4.13e-109	-	-	-	S	-	-	-	ASCH
HIEHEPNM_01584	4.01e-44	-	-	-	-	-	-	-	-
HIEHEPNM_01585	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HIEHEPNM_01586	6.01e-268	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HIEHEPNM_01587	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
HIEHEPNM_01588	2.41e-127	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HIEHEPNM_01589	2.27e-246	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HIEHEPNM_01590	2.08e-286	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
HIEHEPNM_01591	2.57e-224	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
HIEHEPNM_01592	3.43e-206	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIEHEPNM_01593	1.91e-152	yceF	-	-	P	ko:K05794	-	ko00000	membrane
HIEHEPNM_01594	1.27e-76	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HIEHEPNM_01595	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HIEHEPNM_01596	1.85e-59	ylxQ	-	-	J	-	-	-	ribosomal protein
HIEHEPNM_01597	2.02e-62	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
HIEHEPNM_01598	5.2e-273	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
HIEHEPNM_01599	3.81e-110	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
HIEHEPNM_01600	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIEHEPNM_01601	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HIEHEPNM_01602	2.89e-291	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
HIEHEPNM_01603	9.72e-182	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
HIEHEPNM_01604	2.05e-177	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIEHEPNM_01605	4.96e-121	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HIEHEPNM_01606	1.96e-165	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
HIEHEPNM_01607	3.28e-200	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HIEHEPNM_01608	9.72e-182	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
HIEHEPNM_01609	1.29e-63	yazA	-	-	L	ko:K07461	-	ko00000	GIY-YIG catalytic domain protein
HIEHEPNM_01610	1.5e-173	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
HIEHEPNM_01611	4.02e-158	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
HIEHEPNM_01612	2.83e-301	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
HIEHEPNM_01613	7.66e-178	yejC	-	-	S	-	-	-	Protein of unknown function (DUF1003)
HIEHEPNM_01614	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01615	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01616	1.39e-40	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
HIEHEPNM_01617	3.45e-49	ynzC	-	-	S	-	-	-	UPF0291 protein
HIEHEPNM_01618	1.08e-35	-	-	-	-	-	-	-	-
HIEHEPNM_01619	1.16e-74	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HIEHEPNM_01620	2.14e-189	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
HIEHEPNM_01621	9.14e-122	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIEHEPNM_01622	2.2e-51	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
HIEHEPNM_01623	2.97e-59	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
HIEHEPNM_01624	1.02e-301	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIEHEPNM_01625	2.45e-75	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HIEHEPNM_01626	1.47e-33	-	-	-	-	-	-	-	-
HIEHEPNM_01627	1.12e-69	-	-	-	-	-	-	-	-
HIEHEPNM_01628	4.7e-109	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HIEHEPNM_01629	0.0	-	-	-	M	-	-	-	Leucine rich repeats (6 copies)
HIEHEPNM_01630	4.23e-237	-	-	-	-	-	-	-	-
HIEHEPNM_01631	2.91e-39	-	-	-	-	-	-	-	-
HIEHEPNM_01632	3.85e-94	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIEHEPNM_01633	4.41e-113	-	-	-	C	-	-	-	nadph quinone reductase
HIEHEPNM_01634	3.88e-265	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
HIEHEPNM_01635	2.05e-162	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_01636	1.77e-194	hlyD3	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIEHEPNM_01637	2.08e-283	-	-	-	K	-	-	-	IrrE N-terminal-like domain
HIEHEPNM_01638	1.23e-175	-	-	-	-	-	-	-	-
HIEHEPNM_01639	1.29e-25	-	-	-	-	-	-	-	-
HIEHEPNM_01640	7.2e-60	-	-	-	-	-	-	-	-
HIEHEPNM_01641	2.23e-191	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HIEHEPNM_01642	2.92e-170	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HIEHEPNM_01643	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_01644	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	Mga helix-turn-helix domain
HIEHEPNM_01645	5.35e-102	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_01646	1.75e-275	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
HIEHEPNM_01647	9.48e-237	lipA	-	-	I	-	-	-	Carboxylesterase family
HIEHEPNM_01648	2.32e-233	-	-	-	D	ko:K06889	-	ko00000	Alpha beta
HIEHEPNM_01649	3.77e-217	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIEHEPNM_01651	7.89e-216	-	-	-	O	-	-	-	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HIEHEPNM_01652	4.52e-169	-	-	-	F	-	-	-	Glutamine amidotransferase class-I
HIEHEPNM_01653	3.93e-90	-	-	-	-	-	-	-	-
HIEHEPNM_01654	1.96e-192	-	-	-	I	-	-	-	NAD binding domain of 6-phosphogluconate dehydrogenase
HIEHEPNM_01656	3.32e-150	-	1.1.1.29	-	CH	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIEHEPNM_01657	1.43e-123	-	-	-	-	-	-	-	-
HIEHEPNM_01658	4.99e-154	malR	-	-	KT	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
HIEHEPNM_01659	0.0	dpiB	2.7.13.3	-	T	ko:K02476,ko:K11614	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Single cache domain 3
HIEHEPNM_01660	1.04e-289	malP	-	-	C	ko:K11616	ko02020,map02020	ko00000,ko00001	2-hydroxycarboxylate transporter family
HIEHEPNM_01661	1.12e-250	mae	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme, NAD binding domain
HIEHEPNM_01664	5.23e-82	-	-	-	-	-	-	-	-
HIEHEPNM_01665	0.0	-	-	-	-	-	-	-	-
HIEHEPNM_01667	0.0	-	2.4.1.9, 3.4.24.40	GH68	M	ko:K01406,ko:K20811	ko00500,ko01503,map00500,map01503	ko00000,ko00001,ko01000,ko01002	domain protein
HIEHEPNM_01669	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HIEHEPNM_01670	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HIEHEPNM_01671	5.29e-238	mocA	-	-	S	-	-	-	Oxidoreductase
HIEHEPNM_01672	2.75e-118	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_01673	1.6e-145	-	-	-	S	-	-	-	Flavodoxin-like fold
HIEHEPNM_01675	2.4e-80	-	-	-	-	-	-	-	-
HIEHEPNM_01676	3.45e-37	-	-	-	-	-	-	-	-
HIEHEPNM_01677	9.77e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HIEHEPNM_01678	1.1e-50	-	-	-	-	-	-	-	-
HIEHEPNM_01679	2.26e-143	-	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
HIEHEPNM_01680	2.02e-112	XK27_03960	-	-	S	-	-	-	Protein of unknown function (DUF3013)
HIEHEPNM_01681	5.37e-221	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
HIEHEPNM_01682	7.38e-167	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HIEHEPNM_01683	1.7e-70	-	-	-	-	-	-	-	-
HIEHEPNM_01684	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_01685	2.17e-97	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HIEHEPNM_01686	2.95e-147	-	-	-	J	-	-	-	HAD-hyrolase-like
HIEHEPNM_01687	0.0	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-acetylmuramoyl-L-alanine amidase
HIEHEPNM_01688	1.72e-103	-	-	-	FG	-	-	-	adenosine 5'-monophosphoramidase activity
HIEHEPNM_01689	8.06e-200	-	-	-	V	-	-	-	ABC transporter
HIEHEPNM_01690	0.0	-	-	-	-	-	-	-	-
HIEHEPNM_01691	1.8e-308	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
HIEHEPNM_01692	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HIEHEPNM_01693	1.26e-105	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
HIEHEPNM_01694	7.61e-217	yitT	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIEHEPNM_01695	6.26e-215	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HIEHEPNM_01696	4.18e-199	yqfL	2.7.11.33, 2.7.4.28	-	F	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HIEHEPNM_01697	5.66e-29	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
HIEHEPNM_01698	1.47e-90	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
HIEHEPNM_01699	4.39e-34	-	-	-	-	-	-	-	-
HIEHEPNM_01700	2.79e-125	nisT	-	-	V	ko:K06147,ko:K20485	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	ABC transporter
HIEHEPNM_01701	6.53e-174	nisT	-	-	V	ko:K06147,ko:K20485	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	ABC transporter
HIEHEPNM_01703	2.24e-154	-	-	-	S	ko:K03824	-	ko00000,ko01000	Acetyltransferase (GNAT) family
HIEHEPNM_01704	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIEHEPNM_01705	1.3e-298	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HIEHEPNM_01706	0.0	-	-	-	GKT	ko:K03491	-	ko00000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01707	1.17e-247	-	-	-	E	-	-	-	M42 glutamyl aminopeptidase
HIEHEPNM_01708	3.76e-64	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_01709	2.02e-78	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_01710	0.0	-	-	-	U	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_01711	9.39e-256	-	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HIEHEPNM_01712	2.29e-294	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
HIEHEPNM_01713	1.33e-292	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
HIEHEPNM_01714	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HIEHEPNM_01715	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HIEHEPNM_01716	1.11e-84	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIEHEPNM_01717	3.66e-187	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HIEHEPNM_01718	2.07e-179	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_01719	3.25e-107	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_01720	0.0	bgaC	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
HIEHEPNM_01721	5.31e-287	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIEHEPNM_01722	1.15e-280	agaS	-	-	G	ko:K02082	-	ko00000,ko01000	SIS domain
HIEHEPNM_01723	1.43e-166	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HIEHEPNM_01724	1.66e-249	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HIEHEPNM_01725	1.31e-305	manP	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_01726	1.34e-88	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01727	0.0	manR	-	-	G	ko:K02538,ko:K03491	-	ko00000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01728	1.74e-111	-	-	-	-	-	-	-	-
HIEHEPNM_01729	3.9e-304	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIEHEPNM_01730	0.0	uvrB3	3.1.12.1	-	KL	ko:K07464	-	ko00000,ko01000,ko02048	DEAD_2
HIEHEPNM_01731	1.81e-150	-	-	-	-	-	-	-	-
HIEHEPNM_01732	1.1e-197	-	-	-	-	-	-	-	-
HIEHEPNM_01733	4.73e-294	lacG	3.2.1.21, 3.2.1.85	-	G	ko:K01220,ko:K05350	ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_01734	3.11e-75	lacF-1	2.7.1.207	-	G	ko:K02786	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_01735	5.96e-185	-	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
HIEHEPNM_01736	0.0	lacE	2.7.1.207	-	G	ko:K02787,ko:K02788	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase system, EIIC
HIEHEPNM_01737	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
HIEHEPNM_01738	4.22e-216	p75	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
HIEHEPNM_01739	3.14e-166	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
HIEHEPNM_01740	3.78e-292	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HIEHEPNM_01741	2.32e-147	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HIEHEPNM_01742	1.12e-303	pts14C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_01743	5.34e-214	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HIEHEPNM_01744	6.94e-70	-	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
HIEHEPNM_01745	6.48e-157	livF	-	-	E	ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_01746	7.09e-179	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid ATP-binding cassette transporter
HIEHEPNM_01747	8.13e-185	livM	-	-	E	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
HIEHEPNM_01748	5.16e-192	livH	-	-	U	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
HIEHEPNM_01749	4.62e-273	livJ	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Receptor family ligand binding region
HIEHEPNM_01750	5.92e-97	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HIEHEPNM_01751	1.14e-169	-	-	-	S	-	-	-	Putative threonine/serine exporter
HIEHEPNM_01752	2.96e-57	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HIEHEPNM_01753	1.14e-108	-	-	-	M	-	-	-	Protein of unknown function (DUF3737)
HIEHEPNM_01754	5.06e-172	-	-	-	K	ko:K12410	-	ko00000,ko01000	Sir2 family
HIEHEPNM_01755	1.12e-83	pcaC	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
HIEHEPNM_01756	2.93e-85	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HIEHEPNM_01757	0.0	yknV	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
HIEHEPNM_01758	8.34e-271	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HIEHEPNM_01759	5.9e-297	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HIEHEPNM_01760	5.12e-139	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
HIEHEPNM_01761	2.28e-63	-	-	-	S	-	-	-	mazG nucleotide pyrophosphohydrolase
HIEHEPNM_01762	2.34e-28	-	-	-	-	-	-	-	-
HIEHEPNM_01763	0.0	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_01764	1.33e-172	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01765	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HIEHEPNM_01766	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase System
HIEHEPNM_01767	1.21e-212	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HIEHEPNM_01768	5.84e-172	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_01769	1.29e-297	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIEHEPNM_01770	0.0	oatA	-	-	I	-	-	-	Acyltransferase
HIEHEPNM_01771	2.92e-232	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HIEHEPNM_01772	1.28e-181	yqjQ	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
HIEHEPNM_01773	5.47e-63	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
HIEHEPNM_01774	0.0	clpB	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HIEHEPNM_01775	1.35e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
HIEHEPNM_01776	2.41e-71	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
HIEHEPNM_01777	0.0	ycjM	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	5'-nucleotidase, C-terminal domain
HIEHEPNM_01778	2.15e-187	-	-	-	-	-	-	-	-
HIEHEPNM_01779	2.92e-38	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
HIEHEPNM_01780	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
HIEHEPNM_01781	9e-227	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HIEHEPNM_01782	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
HIEHEPNM_01783	7.15e-94	ytwI	-	-	S	-	-	-	Protein of unknown function (DUF441)
HIEHEPNM_01784	7.26e-209	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
HIEHEPNM_01785	2.09e-212	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
HIEHEPNM_01786	2.81e-88	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HIEHEPNM_01787	8.93e-163	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIEHEPNM_01788	6.34e-134	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIEHEPNM_01789	3.03e-178	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HIEHEPNM_01790	5.3e-124	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HIEHEPNM_01791	4.03e-61	fer	-	-	C	ko:K05337	-	ko00000	4Fe-4S single cluster domain of Ferredoxin I
HIEHEPNM_01792	1.83e-231	-	-	-	S	-	-	-	Helix-turn-helix domain
HIEHEPNM_01793	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HIEHEPNM_01794	6.23e-87	-	-	-	M	-	-	-	Lysin motif
HIEHEPNM_01795	1.09e-149	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
HIEHEPNM_01796	6.19e-300	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
HIEHEPNM_01797	3.67e-312	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
HIEHEPNM_01798	1.6e-54	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HIEHEPNM_01799	3.7e-298	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
HIEHEPNM_01800	2.95e-207	ypjC	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIEHEPNM_01801	1.12e-285	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HIEHEPNM_01802	2.08e-110	-	-	-	-	-	-	-	-
HIEHEPNM_01803	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01804	1.03e-244	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HIEHEPNM_01805	1.48e-118	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HIEHEPNM_01806	1.51e-147	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
HIEHEPNM_01807	2.79e-190	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
HIEHEPNM_01808	3.87e-202	XK27_03630	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HIEHEPNM_01809	5.89e-145	ypmS	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2140)
HIEHEPNM_01810	4.24e-102	msrA	1.8.4.11	-	C	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIEHEPNM_01811	2.52e-55	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
HIEHEPNM_01812	0.0	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
HIEHEPNM_01814	6.27e-60	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_01816	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	MMPL family
HIEHEPNM_01817	3.73e-137	-	-	-	K	ko:K22106	-	ko00000,ko03000	Tetracycline repressor, C-terminal all-alpha domain
HIEHEPNM_01818	2.75e-157	-	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
HIEHEPNM_01819	1.21e-309	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
HIEHEPNM_01820	1.3e-89	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
HIEHEPNM_01821	1.68e-191	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
HIEHEPNM_01823	1.37e-142	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIEHEPNM_01824	1.96e-225	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HIEHEPNM_01825	2.13e-136	opuCB	-	-	E	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_01826	7.45e-279	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01827	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	P-type ATPase
HIEHEPNM_01828	1.04e-45	copZ	-	-	P	-	-	-	Heavy-metal-associated domain
HIEHEPNM_01829	6.78e-132	dpsB	-	-	P	-	-	-	Belongs to the Dps family
HIEHEPNM_01830	2.13e-150	flp	-	-	K	ko:K21562	-	ko00000,ko03000	helix_turn_helix, cAMP Regulatory protein
HIEHEPNM_01832	2.81e-201	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIEHEPNM_01833	0.0	-	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02770,ko:K02794,ko:K02795	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_01834	1.99e-104	frvA	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_01835	0.0	mngB	3.2.1.170	GH38	G	ko:K15524	-	ko00000,ko01000	Glycosyl hydrolases family 38 N-terminal domain
HIEHEPNM_01836	1.01e-179	-	-	-	K	-	-	-	SIS domain
HIEHEPNM_01837	0.0	-	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_01838	5.67e-200	bglK_1	-	-	GK	-	-	-	ROK family
HIEHEPNM_01840	2.89e-182	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HIEHEPNM_01841	7.93e-290	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HIEHEPNM_01842	2.84e-136	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
HIEHEPNM_01843	2.09e-170	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
HIEHEPNM_01844	6.58e-231	trpD	2.4.2.18, 4.1.3.27	-	F	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIEHEPNM_01846	0.0	-	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_01847	6.02e-143	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_01848	8.18e-151	-	-	-	-	-	-	-	-
HIEHEPNM_01849	1.39e-198	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-type transport system involved in multi-copper enzyme maturation permease component
HIEHEPNM_01850	2.35e-136	-	-	-	-	-	-	-	-
HIEHEPNM_01851	5.06e-126	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01853	2.26e-136	-	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	dTDP-4-dehydrorhamnose 3,5-epimerase
HIEHEPNM_01854	1.18e-174	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HIEHEPNM_01855	3.74e-210	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIEHEPNM_01856	6.84e-278	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HIEHEPNM_01857	1.03e-114	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HIEHEPNM_01858	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HIEHEPNM_01859	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HIEHEPNM_01860	5.72e-238	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HIEHEPNM_01861	5.83e-251	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HIEHEPNM_01862	9.51e-81	-	-	-	-	-	-	-	-
HIEHEPNM_01863	2.62e-95	-	-	-	L	-	-	-	NUDIX domain
HIEHEPNM_01864	5.16e-192	-	-	-	EG	-	-	-	EamA-like transporter family
HIEHEPNM_01866	2.24e-64	-	-	-	L	-	-	-	PFAM transposase, IS4 family protein
HIEHEPNM_01867	2.4e-137	-	-	-	L	-	-	-	PFAM transposase, IS4 family protein
HIEHEPNM_01868	1.95e-78	-	-	-	K	-	-	-	Tetracyclin repressor, C-terminal all-alpha domain
HIEHEPNM_01869	3.71e-68	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
HIEHEPNM_01870	4.01e-99	-	-	-	P	-	-	-	ABC-2 family transporter protein
HIEHEPNM_01871	3.17e-126	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01872	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
HIEHEPNM_01873	4.7e-98	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HIEHEPNM_01874	3e-221	yqhA	-	-	G	-	-	-	Aldose 1-epimerase
HIEHEPNM_01875	1.23e-161	-	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HIEHEPNM_01876	3.2e-212	-	-	-	T	-	-	-	GHKL domain
HIEHEPNM_01877	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HIEHEPNM_01878	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HIEHEPNM_01879	3.93e-41	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional
HIEHEPNM_01880	3.43e-85	-	-	-	-	-	-	-	-
HIEHEPNM_01881	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIEHEPNM_01882	8.68e-220	pepI	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HIEHEPNM_01883	7.33e-188	yunF	-	-	F	-	-	-	Protein of unknown function DUF72
HIEHEPNM_01884	4.46e-118	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
HIEHEPNM_01885	1.8e-217	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HIEHEPNM_01886	2.35e-139	yiiE	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HIEHEPNM_01887	3.42e-166	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	Sir2 family
HIEHEPNM_01889	6.25e-217	-	-	-	-	-	-	-	-
HIEHEPNM_01890	1.12e-125	yxkA	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
HIEHEPNM_01891	3.78e-51	-	-	-	-	-	-	-	-
HIEHEPNM_01892	3.46e-219	ypuA	-	-	S	-	-	-	Protein of unknown function (DUF1002)
HIEHEPNM_01893	1e-220	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HIEHEPNM_01894	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HIEHEPNM_01895	0.0	ppx3	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HIEHEPNM_01896	4.79e-222	ydhF	-	-	S	-	-	-	Aldo keto reductase
HIEHEPNM_01897	2.94e-198	-	-	-	Q	-	-	-	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
HIEHEPNM_01898	6.53e-118	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
HIEHEPNM_01899	1.3e-302	dinF	-	-	V	-	-	-	MatE
HIEHEPNM_01900	6.41e-141	-	-	-	S	ko:K06872	-	ko00000	TPM domain
HIEHEPNM_01901	4.87e-134	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
HIEHEPNM_01902	6.02e-246	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HIEHEPNM_01903	8.37e-90	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIEHEPNM_01904	0.0	gshR	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
HIEHEPNM_01905	2.58e-226	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_01906	0.0	choS	-	-	EM	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HIEHEPNM_01907	3.48e-245	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIEHEPNM_01908	1.5e-178	ksgA	2.1.1.182, 2.1.1.197, 2.5.1.134	-	J	ko:K02169,ko:K02528,ko:K17216,ko:K17462	ko00270,ko00780,ko01100,ko01230,map00270,map00780,map01100,map01230	ko00000,ko00001,ko00002,ko01000,ko03009	rRNA (adenine-N6,N6-)-dimethyltransferase activity
HIEHEPNM_01909	0.0	-	-	-	S	-	-	-	ABC transporter
HIEHEPNM_01910	2.04e-224	-	3.2.2.24	-	O	ko:K05521	-	ko00000,ko01000	ADP-ribosylglycohydrolase
HIEHEPNM_01911	4.32e-138	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HIEHEPNM_01912	4.9e-69	-	-	-	-	-	-	-	-
HIEHEPNM_01913	6.35e-172	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
HIEHEPNM_01914	5.69e-189	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HIEHEPNM_01915	2.29e-175	glcR	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_01916	4.98e-98	-	-	-	T	-	-	-	Sh3 type 3 domain protein
HIEHEPNM_01917	7.52e-315	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HIEHEPNM_01918	6.87e-256	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIEHEPNM_01919	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
HIEHEPNM_01920	3.89e-205	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	Dehydrogenase
HIEHEPNM_01921	6.52e-215	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HIEHEPNM_01922	2.96e-173	znuB	-	-	U	ko:K02075,ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
HIEHEPNM_01923	8.68e-169	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HIEHEPNM_01924	3.08e-74	-	-	-	-	-	-	-	-
HIEHEPNM_01925	4.61e-270	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	Gluconate
HIEHEPNM_01926	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HIEHEPNM_01927	1.6e-216	gntZ	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
HIEHEPNM_01928	5.62e-190	gntR	-	-	K	-	-	-	rpiR family
HIEHEPNM_01929	2.1e-215	iolH	-	-	G	ko:K06605	-	ko00000	Xylose isomerase-like TIM barrel
HIEHEPNM_01930	1.2e-203	-	5.3.99.11	-	G	ko:K06606	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Xylose isomerase-like TIM barrel
HIEHEPNM_01931	1.75e-87	yodA	-	-	S	-	-	-	Tautomerase enzyme
HIEHEPNM_01932	5.48e-202	iolJ	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_01933	2.99e-222	iolE	4.2.1.44	-	G	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
HIEHEPNM_01934	1.01e-250	iolG2	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
HIEHEPNM_01935	1.12e-245	iolG	1.1.1.18, 1.1.1.369	-	C	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
HIEHEPNM_01936	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
HIEHEPNM_01937	6.58e-227	iolC	2.7.1.92	-	H	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
HIEHEPNM_01938	1.64e-198	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
HIEHEPNM_01939	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HIEHEPNM_01940	0.0	iolT	-	-	EGP	ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HIEHEPNM_01941	1.13e-181	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_01942	1.93e-209	yvgN	-	-	C	-	-	-	Aldo keto reductase
HIEHEPNM_01943	1.83e-180	racD	5.1.1.13	-	G	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
HIEHEPNM_01944	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIEHEPNM_01945	2.55e-111	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HIEHEPNM_01946	5.54e-303	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HIEHEPNM_01947	1.45e-280	hpk31	-	-	T	-	-	-	Histidine kinase
HIEHEPNM_01948	1.68e-156	vanR	-	-	K	-	-	-	response regulator
HIEHEPNM_01949	1.67e-152	-	-	-	-	-	-	-	-
HIEHEPNM_01950	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HIEHEPNM_01951	2.39e-182	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
HIEHEPNM_01952	4.65e-256	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HIEHEPNM_01953	8.4e-42	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
HIEHEPNM_01954	6.39e-201	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HIEHEPNM_01955	3.67e-178	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
HIEHEPNM_01956	5.2e-188	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HIEHEPNM_01957	9.03e-173	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
HIEHEPNM_01958	2.32e-86	-	-	-	-	-	-	-	-
HIEHEPNM_01959	3.57e-165	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
HIEHEPNM_01961	1.89e-133	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
HIEHEPNM_01962	5.7e-153	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HIEHEPNM_01963	5.63e-186	-	-	-	S	-	-	-	Protein of unknown function (DUF979)
HIEHEPNM_01964	4.96e-148	-	-	-	S	-	-	-	Protein of unknown function (DUF969)
HIEHEPNM_01965	2.73e-166	-	3.8.1.2	-	S	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HIEHEPNM_01966	3.02e-87	asp2	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HIEHEPNM_01967	1.62e-80	asp23	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HIEHEPNM_01968	1.32e-39	-	-	-	-	-	-	-	-
HIEHEPNM_01969	1.68e-116	-	-	-	S	-	-	-	Protein conserved in bacteria
HIEHEPNM_01970	1.55e-51	-	-	-	S	-	-	-	Transglycosylase associated protein
HIEHEPNM_01971	1.87e-93	-	-	-	S	ko:K07006	-	ko00000	Pyridoxamine 5'-phosphate oxidase
HIEHEPNM_01972	5.78e-219	-	1.1.1.26	-	CH	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIEHEPNM_01973	4.87e-37	-	-	-	-	-	-	-	-
HIEHEPNM_01974	4.57e-49	-	-	-	-	-	-	-	-
HIEHEPNM_01975	2.23e-107	-	-	-	C	-	-	-	Flavodoxin
HIEHEPNM_01976	7.43e-69	-	-	-	-	-	-	-	-
HIEHEPNM_01977	5.12e-84	-	-	-	-	-	-	-	-
HIEHEPNM_01978	1.47e-07	-	-	-	-	-	-	-	-
HIEHEPNM_01979	1.85e-73	ywjH	-	-	S	-	-	-	Protein of unknown function (DUF1634)
HIEHEPNM_01980	2.86e-183	yunE	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
HIEHEPNM_01981	8.84e-274	-	-	-	S	ko:K06872	-	ko00000	TPM domain
HIEHEPNM_01982	6.18e-150	-	-	-	-	-	-	-	-
HIEHEPNM_01983	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
HIEHEPNM_01984	0.0	fnq20	-	-	S	-	-	-	FAD-NAD(P)-binding
HIEHEPNM_01985	2.66e-271	-	-	-	S	-	-	-	nuclear-transcribed mRNA catabolic process, no-go decay
HIEHEPNM_01986	5.25e-106	-	-	-	S	-	-	-	NUDIX domain
HIEHEPNM_01987	2.2e-97	-	-	-	-	-	-	-	-
HIEHEPNM_01988	2.8e-152	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_01989	6.5e-162	-	-	-	-	-	-	-	-
HIEHEPNM_01990	1.92e-149	-	-	-	-	-	-	-	-
HIEHEPNM_01991	1.65e-116	-	-	-	-	-	-	-	-
HIEHEPNM_01992	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIEHEPNM_01993	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HIEHEPNM_01995	3.79e-28	-	-	-	-	-	-	-	-
HIEHEPNM_01996	7.46e-61	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPase activity
HIEHEPNM_01998	3.47e-112	-	-	-	-	-	-	-	-
HIEHEPNM_02001	3.06e-44	-	-	-	M	-	-	-	domain protein
HIEHEPNM_02002	2.84e-109	-	3.4.23.43	-	-	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	-
HIEHEPNM_02003	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIEHEPNM_02004	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIEHEPNM_02005	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HIEHEPNM_02006	7.17e-104	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
HIEHEPNM_02022	7.81e-94	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Sigma-70 region 2
HIEHEPNM_02023	0.0	ybeC	-	-	E	-	-	-	amino acid
HIEHEPNM_02024	6.32e-294	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HIEHEPNM_02025	7.35e-249	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HIEHEPNM_02026	4.38e-222	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HIEHEPNM_02027	1.51e-279	araT	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIEHEPNM_02028	1.4e-58	ykuJ	-	-	S	-	-	-	Protein of unknown function (DUF1797)
HIEHEPNM_02029	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HIEHEPNM_02030	1.8e-104	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
HIEHEPNM_02031	4.73e-286	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HIEHEPNM_02032	1.98e-205	-	-	-	S	-	-	-	Tetratricopeptide repeat
HIEHEPNM_02033	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HIEHEPNM_02034	6.79e-152	-	-	-	-	-	-	-	-
HIEHEPNM_02035	2.48e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HIEHEPNM_02036	1.01e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
HIEHEPNM_02037	7.05e-248	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
HIEHEPNM_02038	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
HIEHEPNM_02039	1.96e-147	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
HIEHEPNM_02040	2.04e-247	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
HIEHEPNM_02041	2.96e-111	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HIEHEPNM_02042	2.89e-129	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
HIEHEPNM_02043	2.84e-75	ylbG	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
HIEHEPNM_02044	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HIEHEPNM_02045	3.76e-268	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HIEHEPNM_02046	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
HIEHEPNM_02047	1.06e-186	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
HIEHEPNM_02048	8.74e-62	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
HIEHEPNM_02049	7.16e-201	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	L-malate dehydrogenase activity
HIEHEPNM_02050	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
HIEHEPNM_02051	6.23e-314	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HIEHEPNM_02052	1.34e-231	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, C-terminal domain protein
HIEHEPNM_02053	1.65e-266	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
HIEHEPNM_02054	8.12e-174	-	-	-	S	-	-	-	E1-E2 ATPase
HIEHEPNM_02055	1.96e-131	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HIEHEPNM_02056	1.83e-35	-	-	-	-	-	-	-	-
HIEHEPNM_02057	2.95e-96	-	-	-	-	-	-	-	-
HIEHEPNM_02059	4.07e-43	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
HIEHEPNM_02060	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HIEHEPNM_02061	2.93e-235	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HIEHEPNM_02062	2.35e-311	-	-	-	S	-	-	-	Sterol carrier protein domain
HIEHEPNM_02063	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HIEHEPNM_02064	8.3e-150	-	-	-	S	-	-	-	repeat protein
HIEHEPNM_02065	9.46e-159	pgm6	-	-	G	-	-	-	phosphoglycerate mutase
HIEHEPNM_02066	8.38e-278	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HIEHEPNM_02067	1.24e-284	uvrA2	-	-	L	-	-	-	ABC transporter
HIEHEPNM_02069	2.14e-13	ptbA	2.7.1.208	-	G	ko:K02755,ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HIEHEPNM_02070	2.22e-78	ptbA	2.7.1.208	-	G	ko:K02755,ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HIEHEPNM_02071	3.33e-161	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIEHEPNM_02072	6.58e-136	-	-	-	K	-	-	-	Transcriptional activator, Rgg GadR MutR family
HIEHEPNM_02073	4.66e-259	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIEHEPNM_02074	0.0	-	2.7.1.199, 2.7.1.208	-	G	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
HIEHEPNM_02075	0.0	-	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase C-terminal domain
HIEHEPNM_02076	8.53e-65	araR	-	-	K	ko:K02103	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
HIEHEPNM_02077	9.21e-30	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIEHEPNM_02078	2.21e-79	XK27_08455	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_02079	5.55e-83	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HIEHEPNM_02080	9.75e-54	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_02081	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HIEHEPNM_02082	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HIEHEPNM_02083	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HIEHEPNM_02084	4.45e-122	yqaB	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_02085	1.33e-158	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HIEHEPNM_02086	1.97e-92	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HIEHEPNM_02087	0.0	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HIEHEPNM_02088	0.0	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
HIEHEPNM_02089	5.42e-117	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobalamin adenosyltransferase
HIEHEPNM_02090	5.8e-113	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	ECF transporter, substrate-specific component
HIEHEPNM_02091	2.89e-82	-	-	-	S	-	-	-	Domain of unknown function (DUF4430)
HIEHEPNM_02092	0.0	rtpR	1.17.4.2	-	F	ko:K00527	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	ribonucleoside-triphosphate reductase activity
HIEHEPNM_02093	6.51e-103	-	2.4.2.6	-	F	ko:K08728	ko00240,map00240	ko00000,ko00001,ko01000	nucleoside 2-deoxyribosyltransferase
HIEHEPNM_02094	1.64e-203	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HIEHEPNM_02095	8e-131	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
HIEHEPNM_02096	2.53e-31	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HIEHEPNM_02097	3.75e-30	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HIEHEPNM_02098	2.18e-218	ubiA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HIEHEPNM_02099	7.19e-209	menA	2.5.1.74	-	M	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
HIEHEPNM_02101	2.18e-247	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HIEHEPNM_02102	1.53e-216	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HIEHEPNM_02103	6.33e-253	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
HIEHEPNM_02104	2.12e-40	-	-	-	-	-	-	-	-
HIEHEPNM_02106	9.28e-248	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HIEHEPNM_02107	2.34e-204	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
HIEHEPNM_02108	3.71e-105	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HIEHEPNM_02109	7.39e-229	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
HIEHEPNM_02110	0.0	-	-	-	S	ko:K13730	ko05100,map05100	ko00000,ko00001	Uncharacterized protein conserved in bacteria (DUF2252)
HIEHEPNM_02111	6.23e-07	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_02113	3.46e-143	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_02114	1.35e-304	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	Thermophilic metalloprotease (M29)
HIEHEPNM_02115	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HIEHEPNM_02116	5.65e-07	-	-	-	-	-	-	-	-
HIEHEPNM_02118	1.1e-93	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HIEHEPNM_02119	2.05e-63	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_02120	5.1e-301	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
HIEHEPNM_02121	1.14e-228	mocA	-	-	S	-	-	-	Oxidoreductase
HIEHEPNM_02122	3.98e-81	-	-	-	S	-	-	-	Domain of unknown function (DUF4828)
HIEHEPNM_02123	3.83e-79	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HIEHEPNM_02124	1.28e-171	-	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HIEHEPNM_02125	1.05e-40	-	-	-	-	-	-	-	-
HIEHEPNM_02126	1.95e-166	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	prohibitin homologues
HIEHEPNM_02127	7.88e-211	yitS	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HIEHEPNM_02128	7.53e-104	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIEHEPNM_02129	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HIEHEPNM_02130	2.97e-211	-	-	-	S	-	-	-	Polyphosphate nucleotide phosphotransferase, PPK2 family
HIEHEPNM_02131	8.04e-190	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIEHEPNM_02132	8.36e-277	yttB	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_02133	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HIEHEPNM_02134	1.42e-247	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
HIEHEPNM_02135	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIEHEPNM_02136	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HIEHEPNM_02137	1.26e-61	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIEHEPNM_02138	2.36e-260	camS	-	-	S	-	-	-	sex pheromone
HIEHEPNM_02139	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HIEHEPNM_02140	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
HIEHEPNM_02141	1.3e-51	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF898)
HIEHEPNM_02142	2.4e-163	-	3.1.1.5	-	E	ko:K10804	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	GDSL-like Lipase/Acylhydrolase
HIEHEPNM_02143	1.42e-254	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
HIEHEPNM_02145	0.0	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Belongs to the DNA polymerase type-Y family
HIEHEPNM_02146	1.41e-77	-	-	-	-	-	-	-	-
HIEHEPNM_02147	2.24e-106	-	-	-	-	-	-	-	-
HIEHEPNM_02148	1.49e-93	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
HIEHEPNM_02149	2.21e-42	-	-	-	-	-	-	-	-
HIEHEPNM_02150	1.9e-121	-	-	-	S	-	-	-	acetyltransferase
HIEHEPNM_02151	0.0	yclK	-	-	T	-	-	-	Histidine kinase
HIEHEPNM_02152	3.15e-173	yclJ	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
HIEHEPNM_02153	1.55e-91	-	-	-	S	-	-	-	SdpI/YhfL protein family
HIEHEPNM_02155	1.26e-52	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HIEHEPNM_02156	1.4e-35	ytgB	-	-	S	-	-	-	Transglycosylase associated protein
HIEHEPNM_02157	2.3e-23	-	-	-	-	-	-	-	-
HIEHEPNM_02158	2.68e-17	-	-	-	S	-	-	-	Phage head-tail joining protein
HIEHEPNM_02159	1.88e-62	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HIEHEPNM_02160	0.0	-	-	-	S	ko:K06904	-	ko00000	Phage capsid family
HIEHEPNM_02161	4.16e-279	-	-	-	S	-	-	-	Phage portal protein
HIEHEPNM_02162	1.22e-28	-	-	-	-	-	-	-	-
HIEHEPNM_02163	0.0	terL	-	-	S	-	-	-	overlaps another CDS with the same product name
HIEHEPNM_02164	9.4e-105	terS	-	-	L	-	-	-	Phage terminase, small subunit
HIEHEPNM_02166	0.0	-	-	-	S	-	-	-	Virulence-associated protein E
HIEHEPNM_02167	1.29e-197	-	-	-	L	-	-	-	Bifunctional DNA primase/polymerase, N-terminal
HIEHEPNM_02168	1.18e-34	-	-	-	-	-	-	-	-
HIEHEPNM_02169	3.96e-48	-	-	-	-	-	-	-	-
HIEHEPNM_02170	7.95e-29	-	-	-	-	-	-	-	-
HIEHEPNM_02171	1.75e-16	-	-	-	-	-	-	-	-
HIEHEPNM_02172	8.37e-42	-	-	-	-	-	-	-	-
HIEHEPNM_02173	5.48e-57	-	-	-	-	-	-	-	-
HIEHEPNM_02174	2.61e-06	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HIEHEPNM_02175	3.37e-272	sip	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIEHEPNM_02176	0.0	rafA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
HIEHEPNM_02177	2.93e-207	arbZ	-	-	I	-	-	-	Phosphate acyltransferases
HIEHEPNM_02178	6.11e-229	arbY	-	-	M	-	-	-	family 8
HIEHEPNM_02179	1.36e-210	arbx	-	-	M	-	-	-	Glycosyl transferase family 8
HIEHEPNM_02180	1.34e-184	arbV	-	-	I	-	-	-	Phosphate acyltransferases
HIEHEPNM_02181	1.03e-314	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HIEHEPNM_02182	1.58e-96	-	-	-	-	-	-	-	-
HIEHEPNM_02183	3.7e-235	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
HIEHEPNM_02184	1.84e-65	-	-	-	-	-	-	-	-
HIEHEPNM_02185	2.14e-105	-	-	-	-	ko:K02248	-	ko00000,ko00002,ko02044	-
HIEHEPNM_02186	3.45e-63	-	-	-	-	-	-	-	-
HIEHEPNM_02188	2e-64	-	-	-	-	ko:K02245	-	ko00000,ko00002,ko02044	-
HIEHEPNM_02189	1.91e-211	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
HIEHEPNM_02190	5.7e-183	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
HIEHEPNM_02191	1.75e-170	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
HIEHEPNM_02192	1.8e-119	-	-	-	S	-	-	-	VanZ like family
HIEHEPNM_02193	0.0	pepF2	-	-	E	-	-	-	Oligopeptidase F
HIEHEPNM_02194	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HIEHEPNM_02195	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIEHEPNM_02196	2.39e-221	ybbR	-	-	S	-	-	-	YbbR-like protein
HIEHEPNM_02197	2.69e-195	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HIEHEPNM_02198	1.12e-162	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HIEHEPNM_02199	1.16e-234	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02200	7.67e-152	-	-	-	K	-	-	-	Transcriptional regulator
HIEHEPNM_02201	0.0	pacL	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
HIEHEPNM_02203	2.37e-79	-	-	-	-	-	-	-	-
HIEHEPNM_02204	3.85e-116	-	-	-	S	-	-	-	Domain of unknown function (DUF5067)
HIEHEPNM_02205	2.08e-267	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_02206	7.08e-187	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_02207	2.13e-191	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIEHEPNM_02208	9.49e-262	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HIEHEPNM_02209	4.84e-125	-	-	-	K	-	-	-	Cupin domain
HIEHEPNM_02210	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HIEHEPNM_02211	2.74e-211	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
HIEHEPNM_02212	3.32e-191	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HIEHEPNM_02213	1.62e-128	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HIEHEPNM_02214	2.05e-278	ysdA	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIEHEPNM_02215	2.96e-210	-	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_02216	1.2e-106	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
HIEHEPNM_02217	6.35e-230	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
HIEHEPNM_02218	4.68e-168	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HIEHEPNM_02219	4.87e-204	ycsE	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIEHEPNM_02220	5.33e-119	-	-	-	-	-	-	-	-
HIEHEPNM_02221	7.94e-134	-	-	-	K	ko:K06977	-	ko00000	Acetyltransferase (GNAT) domain
HIEHEPNM_02222	3.49e-248	malK	-	-	P	ko:K10112,ko:K17240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_02223	1.21e-213	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	ABC-type sugar transport systems, permease components
HIEHEPNM_02224	1.1e-188	malF	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIEHEPNM_02225	5.23e-313	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIEHEPNM_02226	6.97e-304	YSH1	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Metallo-beta-lactamase superfamily
HIEHEPNM_02228	7.78e-66	-	-	-	-	-	-	-	-
HIEHEPNM_02229	3.38e-149	-	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HIEHEPNM_02230	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
HIEHEPNM_02231	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HIEHEPNM_02232	9.03e-108	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HIEHEPNM_02233	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HIEHEPNM_02234	3.69e-177	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Serine aminopeptidase, S33
HIEHEPNM_02235	2.92e-42	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HIEHEPNM_02236	1.48e-78	-	-	-	-	-	-	-	-
HIEHEPNM_02237	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HIEHEPNM_02238	5.53e-84	-	-	-	-	-	-	-	-
HIEHEPNM_02239	5.04e-314	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HIEHEPNM_02240	8.05e-180	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HIEHEPNM_02241	1.52e-282	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
HIEHEPNM_02242	2.99e-247	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HIEHEPNM_02243	2.73e-241	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	Putative sugar-binding domain
HIEHEPNM_02245	1.71e-131	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HIEHEPNM_02246	1.43e-32	ohrR	-	-	K	ko:K18906	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
HIEHEPNM_02247	1.8e-47	ohrR	-	-	K	ko:K18906	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
HIEHEPNM_02248	3.36e-220	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
HIEHEPNM_02249	8.22e-246	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
HIEHEPNM_02250	1.47e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
HIEHEPNM_02251	2.98e-110	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HIEHEPNM_02252	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HIEHEPNM_02253	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HIEHEPNM_02254	2.32e-152	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
HIEHEPNM_02255	2.3e-178	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HIEHEPNM_02256	4.45e-105	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HIEHEPNM_02257	1.21e-117	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02258	3.28e-143	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
HIEHEPNM_02259	2.18e-109	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HIEHEPNM_02260	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HIEHEPNM_02261	8.36e-230	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HIEHEPNM_02262	1.8e-249	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
HIEHEPNM_02263	2e-201	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HIEHEPNM_02264	5.82e-223	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HIEHEPNM_02265	2.28e-61	yvlD	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
HIEHEPNM_02266	7.01e-49	-	-	-	-	-	-	-	-
HIEHEPNM_02267	0.0	yvlB	-	-	S	-	-	-	Putative adhesin
HIEHEPNM_02268	1.33e-156	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HIEHEPNM_02269	1.75e-180	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIEHEPNM_02270	1.83e-191	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIEHEPNM_02271	3.55e-200	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HIEHEPNM_02272	1.56e-205	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HIEHEPNM_02273	5.25e-199	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HIEHEPNM_02274	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIEHEPNM_02275	9.79e-168	phoP	-	-	K	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HIEHEPNM_02276	7.95e-251	minJ	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
HIEHEPNM_02277	4.17e-204	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HIEHEPNM_02278	2.59e-160	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	ABC transporter
HIEHEPNM_02279	6.43e-238	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HIEHEPNM_02280	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HIEHEPNM_02281	7.96e-127	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HIEHEPNM_02282	1.8e-117	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
HIEHEPNM_02283	3.04e-297	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
HIEHEPNM_02284	1.57e-151	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
HIEHEPNM_02285	0.0	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
HIEHEPNM_02286	2.37e-29	-	-	-	-	-	-	-	-
HIEHEPNM_02287	1.28e-07	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIEHEPNM_02288	6.68e-240	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HIEHEPNM_02289	3.23e-288	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
HIEHEPNM_02290	7.88e-135	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIEHEPNM_02291	1.8e-167	ymfM	-	-	S	ko:K15539	-	ko00000	Helix-turn-helix domain
HIEHEPNM_02292	1.43e-164	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HIEHEPNM_02293	3.94e-309	ymfH	-	-	S	-	-	-	Peptidase M16
HIEHEPNM_02294	7.4e-293	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
HIEHEPNM_02295	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HIEHEPNM_02296	8.84e-93	-	-	-	S	-	-	-	Protein of unknown function (DUF1149)
HIEHEPNM_02297	6.48e-125	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HIEHEPNM_02298	0.0	-	-	-	L	-	-	-	Transposase DDE domain
HIEHEPNM_02299	1.02e-22	-	-	-	L	ko:K07467	-	ko00000	Replication initiation factor
HIEHEPNM_02301	5.66e-08	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HIEHEPNM_02302	8.99e-99	-	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
HIEHEPNM_02303	2.26e-64	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
HIEHEPNM_02304	4.51e-127	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HIEHEPNM_02305	3.26e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HIEHEPNM_02306	5.33e-119	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
HIEHEPNM_02307	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit I
HIEHEPNM_02308	2.05e-233	-	-	-	C	-	-	-	Cytochrome bd terminal oxidase subunit II
HIEHEPNM_02309	7.17e-39	-	-	-	-	-	-	-	-
HIEHEPNM_02310	7.49e-138	XK27_07085	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIEHEPNM_02311	4.82e-109	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	Best Blastp hit gi 7514214 pir G75157 'abc transporter, ATP-binding protein, puta tive PAB2069 - Pyrococcus abyssi (strain Orsay)' gi 5457852 emb CAB49342.1 '(AJ248284) ABC transporter, ATP-binding protein, puta tive Pyrococcus abyssi ', score 77, E-value 3.00E-13
HIEHEPNM_02312	9.45e-198	rrmA	2.1.1.187	-	H	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase
HIEHEPNM_02313	9.63e-220	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HIEHEPNM_02314	9.97e-245	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HIEHEPNM_02315	4.12e-56	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIEHEPNM_02316	7.55e-82	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
HIEHEPNM_02317	3.13e-252	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
HIEHEPNM_02318	1.61e-185	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HIEHEPNM_02319	1.51e-144	cutC	-	-	P	ko:K06201	-	ko00000	Participates in the control of copper homeostasis
HIEHEPNM_02320	3.99e-258	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HIEHEPNM_02321	5.18e-221	yjbO	5.4.99.23	-	G	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HIEHEPNM_02322	2.24e-193	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HIEHEPNM_02323	4.15e-160	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
HIEHEPNM_02324	8.17e-135	-	-	-	S	-	-	-	CYTH
HIEHEPNM_02325	8.12e-151	yjbH	-	-	Q	-	-	-	Thioredoxin
HIEHEPNM_02326	1.17e-270	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
HIEHEPNM_02327	3.14e-310	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
HIEHEPNM_02328	1.19e-50	XK27_08630	-	-	T	ko:K07166	-	ko00000	Belongs to the UPF0237 family
HIEHEPNM_02329	5.43e-281	cpdA	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIEHEPNM_02330	1.49e-287	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
HIEHEPNM_02331	3.41e-112	gpo	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
HIEHEPNM_02333	9.29e-123	-	-	-	F	-	-	-	NUDIX domain
HIEHEPNM_02334	2.06e-174	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HIEHEPNM_02335	8.09e-48	yhcC	-	-	S	ko:K07069	-	ko00000	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HIEHEPNM_02336	6.61e-167	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HIEHEPNM_02337	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HIEHEPNM_02338	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
HIEHEPNM_02339	2.47e-154	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
HIEHEPNM_02340	1.25e-153	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HIEHEPNM_02341	6.18e-45	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HIEHEPNM_02342	5.48e-274	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HIEHEPNM_02343	3.41e-107	-	-	-	K	-	-	-	MerR HTH family regulatory protein
HIEHEPNM_02344	0.0	mdr	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_02345	1.66e-269	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HIEHEPNM_02346	1e-138	-	-	-	-	-	-	-	-
HIEHEPNM_02348	9.57e-15	-	-	-	G	-	-	-	Acyltransferase family
HIEHEPNM_02349	7.5e-190	cad	-	-	S	ko:K20379	ko02024,map02024	ko00000,ko00001	FMN_bind
HIEHEPNM_02350	1.13e-278	ndh	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HIEHEPNM_02351	7.6e-176	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
HIEHEPNM_02352	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_02353	2.24e-84	-	-	-	-	-	-	-	-
HIEHEPNM_02354	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HIEHEPNM_02355	6.82e-104	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
HIEHEPNM_02356	0.0	poxL	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HIEHEPNM_02358	8.72e-279	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
HIEHEPNM_02359	4.29e-265	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
HIEHEPNM_02360	7.3e-268	atoB	1.1.1.88, 2.3.1.9	-	I	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HIEHEPNM_02361	6.7e-62	-	-	-	-	-	-	-	-
HIEHEPNM_02362	5.52e-204	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
HIEHEPNM_02363	1.49e-132	-	-	-	V	ko:K07448	-	ko00000,ko02048	Restriction endonuclease
HIEHEPNM_02364	2.96e-204	-	-	-	G	-	-	-	Aldose 1-epimerase
HIEHEPNM_02365	4.58e-269	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HIEHEPNM_02366	6.88e-129	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HIEHEPNM_02368	1.4e-105	-	-	-	K	-	-	-	FR47-like protein
HIEHEPNM_02369	8.49e-105	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
HIEHEPNM_02370	1.59e-165	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_02371	1.25e-175	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIEHEPNM_02372	1.88e-225	XK27_08835	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02373	2.37e-95	-	-	-	-	-	-	-	-
HIEHEPNM_02374	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HIEHEPNM_02375	1.01e-275	-	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_02376	4.16e-194	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HIEHEPNM_02377	1.3e-284	-	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_02378	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HIEHEPNM_02379	2.79e-162	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
HIEHEPNM_02380	2.49e-278	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIEHEPNM_02381	7.93e-178	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HIEHEPNM_02382	0.0	yuxL	3.4.19.1	-	E	ko:K01303	-	ko00000,ko01000,ko01002	Prolyl oligopeptidase family
HIEHEPNM_02383	0.0	-	-	-	D	-	-	-	Domain of Unknown Function (DUF1542)
HIEHEPNM_02384	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HIEHEPNM_02386	1.92e-200	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIEHEPNM_02387	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
HIEHEPNM_02388	0.0	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_02389	2.43e-87	-	-	-	-	-	-	-	-
HIEHEPNM_02390	1.39e-96	-	-	-	S	-	-	-	function, without similarity to other proteins
HIEHEPNM_02391	0.0	-	-	-	G	-	-	-	MFS/sugar transport protein
HIEHEPNM_02392	1.17e-295	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
HIEHEPNM_02393	3.89e-75	-	-	-	-	-	-	-	-
HIEHEPNM_02394	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Phosphoenolpyruvate carboxykinase
HIEHEPNM_02395	4.52e-34	-	-	-	S	-	-	-	Virus attachment protein p12 family
HIEHEPNM_02396	3.41e-313	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
HIEHEPNM_02397	9.93e-175	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
HIEHEPNM_02398	3.58e-128	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA
HIEHEPNM_02399	5.26e-153	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
HIEHEPNM_02400	1.12e-115	-	-	-	E	-	-	-	AAA domain
HIEHEPNM_02403	2.62e-152	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
HIEHEPNM_02404	2.78e-118	-	-	-	S	-	-	-	MucBP domain
HIEHEPNM_02405	5.24e-113	-	-	-	-	-	-	-	-
HIEHEPNM_02415	1.33e-85	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_02416	7.35e-70	-	-	-	-	-	-	-	-
HIEHEPNM_02417	1.04e-189	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
HIEHEPNM_02418	5.57e-216	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIEHEPNM_02419	8.35e-84	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HIEHEPNM_02420	4.25e-85	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
HIEHEPNM_02421	2.95e-106	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HIEHEPNM_02422	6.59e-229	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
HIEHEPNM_02424	1.13e-93	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HIEHEPNM_02425	1.45e-46	-	-	-	-	-	-	-	-
HIEHEPNM_02426	8.34e-86	-	-	-	K	-	-	-	Helix-turn-helix domain
HIEHEPNM_02427	1.94e-100	usp5	-	-	T	-	-	-	universal stress protein
HIEHEPNM_02428	2.08e-145	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HIEHEPNM_02429	5.69e-207	-	-	-	EG	-	-	-	EamA-like transporter family
HIEHEPNM_02430	1.57e-34	-	-	-	-	-	-	-	-
HIEHEPNM_02431	5.18e-114	-	-	-	-	-	-	-	-
HIEHEPNM_02432	3.38e-50	-	-	-	-	-	-	-	-
HIEHEPNM_02433	8.01e-231	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HIEHEPNM_02434	3.89e-302	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	pyrimidine-nucleoside phosphorylase
HIEHEPNM_02435	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
HIEHEPNM_02436	4.14e-232	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
HIEHEPNM_02437	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HIEHEPNM_02438	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HIEHEPNM_02440	1.77e-227	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
HIEHEPNM_02441	6.36e-98	-	-	-	S	-	-	-	NusG domain II
HIEHEPNM_02442	0.0	cydD1	-	-	CO	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIEHEPNM_02443	0.0	msbA9	-	-	V	ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIEHEPNM_02444	1.99e-204	bglG4	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
HIEHEPNM_02445	0.0	bglP	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_02446	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_02447	1.69e-186	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	reductase
HIEHEPNM_02448	6.91e-149	-	-	-	I	-	-	-	ABC-2 family transporter protein
HIEHEPNM_02449	7.25e-206	CcmA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02450	1.13e-84	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
HIEHEPNM_02451	1.39e-278	ysdA	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIEHEPNM_02452	1.04e-213	ysdB	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02453	1.35e-283	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIEHEPNM_02454	4.43e-224	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HIEHEPNM_02455	1.76e-205	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HIEHEPNM_02456	4.35e-263	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIEHEPNM_02457	2.44e-06	lacC	2.7.1.144	-	H	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HIEHEPNM_02458	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HIEHEPNM_02459	4.41e-220	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HIEHEPNM_02460	2.91e-223	-	-	-	V	ko:K01421	-	ko00000	domain protein
HIEHEPNM_02461	2.96e-132	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_02462	1.06e-185	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HIEHEPNM_02463	3.3e-162	WQ51_05710	-	-	S	-	-	-	Mitochondrial biogenesis AIM24
HIEHEPNM_02464	6.61e-277	aspC	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIEHEPNM_02465	6.32e-228	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIEHEPNM_02466	1.16e-211	pfoSR	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
HIEHEPNM_02467	6.68e-89	-	-	-	-	-	-	-	-
HIEHEPNM_02468	4.95e-286	floL	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	SPFH domain / Band 7 family
HIEHEPNM_02469	0.0	-	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HIEHEPNM_02470	7.93e-291	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
HIEHEPNM_02471	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
HIEHEPNM_02472	3.54e-199	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HIEHEPNM_02473	9.92e-317	yxbA	6.3.1.12	-	S	ko:K17810	-	ko00000,ko01000	ATP-grasp enzyme
HIEHEPNM_02474	7.15e-94	usp1	-	-	T	-	-	-	Universal stress protein family
HIEHEPNM_02475	2.9e-169	sfsA	-	-	S	ko:K06206	-	ko00000	Belongs to the SfsA family
HIEHEPNM_02476	4.36e-283	gbuA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
HIEHEPNM_02477	3.51e-190	gbuB	-	-	E	ko:K02001	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HIEHEPNM_02478	1.17e-217	gbuC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HIEHEPNM_02479	0.0	-	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HIEHEPNM_02480	3.45e-86	gtcA2	-	-	S	-	-	-	Teichoic acid glycosylation protein
HIEHEPNM_02481	2.05e-164	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HIEHEPNM_02482	1.77e-239	ydbI	-	-	K	-	-	-	AI-2E family transporter
HIEHEPNM_02483	3.38e-252	pbpX	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_02484	1.17e-193	-	-	-	S	-	-	-	zinc-ribbon domain
HIEHEPNM_02485	1.39e-40	-	-	-	-	-	-	-	-
HIEHEPNM_02486	1.15e-168	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIEHEPNM_02487	1.63e-109	-	-	-	F	-	-	-	NUDIX domain
HIEHEPNM_02488	2.64e-134	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
HIEHEPNM_02489	3.44e-236	-	-	-	-	-	-	-	-
HIEHEPNM_02490	7.01e-209	-	-	-	S	-	-	-	Putative esterase
HIEHEPNM_02491	2.95e-13	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
HIEHEPNM_02492	3.31e-89	-	-	-	K	ko:K18909	-	ko00000,ko00002,ko01504,ko03000	MarR family
HIEHEPNM_02493	9.17e-37	-	-	-	-	-	-	-	-
HIEHEPNM_02494	2.87e-92	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
HIEHEPNM_02495	8.04e-205	nox	-	-	C	-	-	-	NADH oxidase
HIEHEPNM_02496	6.21e-69	-	-	-	T	-	-	-	diguanylate cyclase
HIEHEPNM_02497	6.57e-100	ydaJ	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HIEHEPNM_02498	9.57e-78	-	-	-	-	-	-	-	-
HIEHEPNM_02499	3.07e-99	-	-	-	S	-	-	-	Protein conserved in bacteria
HIEHEPNM_02500	2.24e-228	ydaM	-	-	M	-	-	-	Glycosyl transferase family group 2
HIEHEPNM_02501	3.4e-257	-	-	-	S	-	-	-	Bacterial cellulose synthase subunit
HIEHEPNM_02502	5.55e-101	-	-	-	T	-	-	-	diguanylate cyclase activity
HIEHEPNM_02503	3.16e-109	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HIEHEPNM_02504	6.3e-82	-	-	-	P	-	-	-	Rhodanese-like domain
HIEHEPNM_02505	1.42e-288	-	-	-	C	-	-	-	Iron-containing alcohol dehydrogenase
HIEHEPNM_02506	2.01e-243	-	-	-	I	-	-	-	carboxylic ester hydrolase activity
HIEHEPNM_02507	7.93e-94	-	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
HIEHEPNM_02508	2.44e-99	-	-	-	K	-	-	-	Winged helix DNA-binding domain
HIEHEPNM_02509	1.67e-222	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HIEHEPNM_02510	5.61e-45	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIEHEPNM_02511	3.91e-220	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Nitronate monooxygenase
HIEHEPNM_02512	4.19e-210	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
HIEHEPNM_02513	3.37e-163	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
HIEHEPNM_02514	4.03e-283	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HIEHEPNM_02515	3.52e-78	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HIEHEPNM_02516	4.77e-100	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HIEHEPNM_02517	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
HIEHEPNM_02518	1.45e-192	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HIEHEPNM_02519	1.02e-185	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	alpha subunit
HIEHEPNM_02520	6.84e-298	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
HIEHEPNM_02521	1.58e-205	-	-	-	GM	-	-	-	NmrA-like family
HIEHEPNM_02523	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
HIEHEPNM_02524	8.54e-223	purR2	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HIEHEPNM_02525	0.0	malL	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_02526	0.0	pts26BCA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_02527	0.0	pip	-	-	V	ko:K01421	-	ko00000	domain protein
HIEHEPNM_02528	5.8e-270	-	-	-	-	-	-	-	-
HIEHEPNM_02529	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
HIEHEPNM_02530	4.92e-268	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
HIEHEPNM_02531	3.16e-100	-	-	-	V	-	-	-	Type I restriction modification DNA specificity domain
HIEHEPNM_02532	2.01e-213	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIEHEPNM_02533	2.67e-79	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain protein
HIEHEPNM_02534	2.5e-155	-	-	-	-	-	-	-	-
HIEHEPNM_02535	1.4e-282	-	-	-	F	ko:K10974	-	ko00000,ko02000	Permease for cytosine/purines, uracil, thiamine, allantoin
HIEHEPNM_02536	9.89e-264	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
HIEHEPNM_02537	0.0	hyuA	-	-	EQ	-	-	-	Hydantoinase/oxoprolinase N-terminal region
HIEHEPNM_02539	0.0	-	-	-	G	-	-	-	Phosphodiester glycosidase
HIEHEPNM_02540	1.38e-185	frlD1	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
HIEHEPNM_02541	1.61e-129	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_02542	1.36e-139	-	-	-	-	-	-	-	-
HIEHEPNM_02543	0.0	-	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Helix-hairpin-helix containing domain
HIEHEPNM_02544	1.36e-101	-	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Helix-hairpin-helix containing domain
HIEHEPNM_02545	5.85e-171	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2087)
HIEHEPNM_02546	1.75e-172	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
HIEHEPNM_02547	0.0	galA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
HIEHEPNM_02548	0.0	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIEHEPNM_02549	9.16e-91	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HIEHEPNM_02550	9.25e-271	ybhE	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HIEHEPNM_02551	5.35e-70	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HIEHEPNM_02552	7.64e-131	-	-	-	-	-	-	-	-
HIEHEPNM_02553	5.69e-189	lutA	-	-	C	ko:K18928	-	ko00000	Cysteine-rich domain
HIEHEPNM_02554	0.0	lutB	-	-	C	ko:K18929	-	ko00000	4Fe-4S dicluster domain
HIEHEPNM_02555	8.69e-167	lutC	-	-	S	ko:K00782	-	ko00000	LUD domain
HIEHEPNM_02556	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HIEHEPNM_02557	5.32e-209	metF	1.5.1.20	-	C	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
HIEHEPNM_02558	3.96e-187	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Phosphomethylpyrimidine kinase
HIEHEPNM_02559	2.58e-101	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
HIEHEPNM_02560	7.71e-185	CcmA5	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIEHEPNM_02561	0.0	-	-	-	-	-	-	-	-
HIEHEPNM_02562	1.21e-211	yicL	-	-	EG	-	-	-	EamA-like transporter family
HIEHEPNM_02563	0.0	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
HIEHEPNM_02564	6.79e-152	-	-	-	N	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_02565	2.63e-73	-	-	-	-	-	-	-	-
HIEHEPNM_02566	3.52e-163	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_02568	6.7e-304	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
HIEHEPNM_02569	3.8e-61	-	-	-	-	-	-	-	-
HIEHEPNM_02570	1.18e-228	-	-	-	S	-	-	-	Cell surface protein
HIEHEPNM_02571	3.31e-98	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HIEHEPNM_02572	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HIEHEPNM_02573	2.12e-173	-	-	-	-	-	-	-	-
HIEHEPNM_02574	9.6e-156	tcyB	-	-	E	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIEHEPNM_02575	1.61e-184	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
HIEHEPNM_02576	3.92e-269	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HIEHEPNM_02578	2.58e-179	-	-	-	-	-	-	-	-
HIEHEPNM_02580	1.27e-221	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HIEHEPNM_02581	9.58e-209	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to
HIEHEPNM_02582	4.03e-104	-	-	-	S	ko:K08996	-	ko00000	Protein of unknown function (DUF1440)
HIEHEPNM_02583	2.09e-302	xylP	-	-	G	-	-	-	MFS/sugar transport protein
HIEHEPNM_02584	0.0	ycaM	-	-	E	-	-	-	amino acid
HIEHEPNM_02585	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
HIEHEPNM_02586	8.65e-136	-	-	-	-	-	-	-	-
HIEHEPNM_02587	1.81e-252	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HIEHEPNM_02588	8.79e-208	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
HIEHEPNM_02589	7.75e-258	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HIEHEPNM_02590	1.98e-163	-	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
HIEHEPNM_02591	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HIEHEPNM_02592	2.47e-166	XK27_12140	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIEHEPNM_02593	1e-251	-	-	-	-	-	-	-	-
HIEHEPNM_02594	2.64e-164	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HIEHEPNM_02595	9.54e-78	ydeP	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HIEHEPNM_02596	4.95e-246	qor	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
HIEHEPNM_02597	1.52e-207	-	-	-	S	-	-	-	reductase
HIEHEPNM_02598	1.82e-97	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HIEHEPNM_02599	6.46e-290	-	-	-	E	-	-	-	Amino acid permease
HIEHEPNM_02600	5.06e-282	-	-	-	S	ko:K07045	-	ko00000	Amidohydrolase
HIEHEPNM_02601	0.0	-	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	Glutamine synthetase N-terminal domain
HIEHEPNM_02602	2.96e-101	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HIEHEPNM_02603	6.71e-135	-	-	-	S	-	-	-	Nucleotidyl transferase AbiEii toxin, Type IV TA system
HIEHEPNM_02604	3.54e-180	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
HIEHEPNM_02605	1.29e-177	-	-	-	H	-	-	-	Protein of unknown function (DUF1698)
HIEHEPNM_02606	2.26e-245	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HIEHEPNM_02607	1.69e-192	pbpE	-	-	V	-	-	-	Beta-lactamase
HIEHEPNM_02608	5.86e-61	-	-	-	-	-	-	-	-
HIEHEPNM_02609	0.0	cidC	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HIEHEPNM_02610	7.61e-215	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
HIEHEPNM_02611	4.01e-44	-	-	-	-	-	-	-	-
HIEHEPNM_02613	4.31e-97	-	-	-	L	-	-	-	Resolvase, N-terminal
HIEHEPNM_02614	2.19e-136	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HIEHEPNM_02615	8.1e-262	yceJ	-	-	EGP	ko:K08221	-	ko00000,ko02000	transporter
HIEHEPNM_02616	1.04e-64	yczG	-	-	K	-	-	-	Helix-turn-helix domain
HIEHEPNM_02617	1.52e-39	-	-	-	-	-	-	-	-
HIEHEPNM_02618	1.27e-37	-	-	-	L	-	-	-	RelB antitoxin
HIEHEPNM_02619	0.0	-	-	-	L	-	-	-	Exonuclease
HIEHEPNM_02623	2.52e-16	-	-	-	-	-	-	-	-
HIEHEPNM_02624	1.75e-100	-	-	-	O	-	-	-	OsmC-like protein
HIEHEPNM_02625	2.84e-240	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
HIEHEPNM_02626	1.42e-133	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
HIEHEPNM_02627	1.22e-77	dhaM	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
HIEHEPNM_02628	1.18e-134	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_02629	1.61e-24	-	-	-	-	-	-	-	-
HIEHEPNM_02630	0.0	l1n	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
HIEHEPNM_02631	2.77e-222	-	-	-	-	-	-	-	-
HIEHEPNM_02632	9.29e-250	-	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
HIEHEPNM_02633	2.12e-192	metQ1	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HIEHEPNM_02638	1.35e-174	ant1	2.7.7.47	-	H	ko:K00984	-	ko00000,ko01000,ko01504	Mediates bacterial resistance to the antibiotics streptomycin and spectomycin
HIEHEPNM_02639	0.0	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_02640	5.03e-80	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIEHEPNM_02641	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
HIEHEPNM_02642	3.49e-185	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HIEHEPNM_02643	2.05e-165	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_02644	8.14e-98	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_02645	1.8e-209	-	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HIEHEPNM_02646	8.23e-61	-	-	-	S	ko:K19157	-	ko00000,ko01000,ko02048	Bacterial toxin of type II toxin-antitoxin system, YafQ
HIEHEPNM_02647	2.15e-193	-	-	-	S	-	-	-	hydrolase
HIEHEPNM_02648	0.0	npr	1.11.1.1	-	C	ko:K05910	-	ko00000,ko01000	NADH oxidase
HIEHEPNM_02649	7.08e-154	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIEHEPNM_02650	1.56e-235	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HIEHEPNM_02651	2.54e-112	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIEHEPNM_02652	1.98e-186	-	-	-	M	-	-	-	hydrolase, family 25
HIEHEPNM_02653	4.39e-25	-	-	-	S	-	-	-	YvrJ protein family
HIEHEPNM_02655	1.48e-163	-	-	-	-	-	-	-	-
HIEHEPNM_02656	1.84e-73	-	-	-	C	-	-	-	nitroreductase
HIEHEPNM_02657	1.74e-15	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
HIEHEPNM_02658	8.41e-244	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02659	2.4e-92	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HIEHEPNM_02660	1.67e-109	-	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
HIEHEPNM_02661	3.51e-233	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_02662	3.78e-42	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_02663	9.29e-58	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02664	8.9e-83	kdsD	5.3.1.13	-	M	ko:K06041	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
HIEHEPNM_02665	8.71e-271	-	-	-	G	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02666	7.61e-240	malY	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
HIEHEPNM_02667	0.0	pts31BC	-	-	G	ko:K11202,ko:K11203	-	ko00000,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_02668	2.4e-80	-	-	-	G	ko:K11201	-	ko00000,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02669	4.07e-24	-	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
HIEHEPNM_02670	2.64e-218	-	3.2.1.122, 3.2.1.86	GH4,GT4	G	ko:K01222,ko:K01232	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
HIEHEPNM_02671	8.16e-108	-	3.5.1.105	-	G	ko:K03478	-	ko00000,ko01000	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides
HIEHEPNM_02672	4.05e-258	-	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
HIEHEPNM_02673	2.92e-248	xylB	2.7.1.17, 2.7.1.53	-	G	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the FGGY kinase family
HIEHEPNM_02674	5.1e-144	-	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Pfam:DUF1498
HIEHEPNM_02675	3.92e-159	-	-	-	G	-	-	-	Domain of unknown function (DUF4432)
HIEHEPNM_02676	9.7e-211	-	-	-	G	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase System
HIEHEPNM_02677	4.75e-58	-	2.7.1.202	-	G	ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_02678	9.91e-87	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02679	2.17e-215	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_02680	4.54e-40	ptsN	2.7.1.194, 2.7.1.200, 2.7.1.202, 2.7.1.204	-	G	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K03491,ko:K11201,ko:K20112	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIEHEPNM_02681	8.13e-294	-	-	-	K	ko:K02538	-	ko00000,ko03000	PRD domain
HIEHEPNM_02682	6.59e-291	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIEHEPNM_02683	3.04e-293	bglP11	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	pts system
HIEHEPNM_02684	1.74e-116	-	-	-	K	ko:K03488	-	ko00000,ko03000	antiterminator
HIEHEPNM_02685	3.75e-65	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HIEHEPNM_02686	1.01e-56	ptbA	2.7.1.208	-	G	ko:K02755,ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HIEHEPNM_02687	1.91e-11	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
HIEHEPNM_02689	8.14e-48	glvR	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
HIEHEPNM_02690	1.25e-263	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
HIEHEPNM_02691	4.21e-277	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase C-terminal domain
HIEHEPNM_02692	1.66e-84	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIEHEPNM_02693	1.54e-166	-	-	-	S	-	-	-	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity
HIEHEPNM_02694	4.79e-35	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIEHEPNM_02695	3.85e-230	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_02696	8e-41	ulaC	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02697	2.26e-72	gntR	-	-	K	-	-	-	rpiR family
HIEHEPNM_02698	2.12e-65	-	2.7.1.144	-	H	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HIEHEPNM_02699	1.62e-81	-	-	-	K	ko:K02530	-	ko00000,ko03000	DeoR C terminal sensor domain
HIEHEPNM_02700	4.95e-39	pts36A	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02701	1.47e-08	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_02702	2.02e-236	pts36C	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	iic component
HIEHEPNM_02704	1.88e-123	-	4.1.2.17	-	G	ko:K01628	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Class II Aldolase and Adducin N-terminal domain
HIEHEPNM_02705	0.0	frdC	1.3.5.1, 1.3.5.4	-	C	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	ko00000,ko00001,ko00002,ko01000	HI0933-like protein
HIEHEPNM_02706	1.09e-296	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_02707	3.54e-57	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIEHEPNM_02708	4.15e-312	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
HIEHEPNM_02709	6.08e-192	cytR	-	-	K	ko:K02529,ko:K03604	-	ko00000,ko03000	Transcriptional regulator, LacI family
HIEHEPNM_02710	1.02e-188	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
HIEHEPNM_02711	0.0	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding cassette cobalt transporter
HIEHEPNM_02712	1.43e-125	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
HIEHEPNM_02713	2.63e-203	XK27_10120	-	-	K	-	-	-	S-adenosyl-l-methionine hydroxide adenosyltransferase
HIEHEPNM_02714	3.95e-138	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
HIEHEPNM_02715	3.7e-217	-	-	-	C	-	-	-	FAD dependent oxidoreductase
HIEHEPNM_02716	7.42e-303	sdcS	-	-	P	ko:K14445	-	ko00000,ko02000	transporter
HIEHEPNM_02717	1.12e-189	kbaY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_02718	5.62e-191	manZ	-	-	G	ko:K02796,ko:K02815	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HIEHEPNM_02719	1.64e-176	-	-	-	U	ko:K02746,ko:K02795,ko:K02814	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HIEHEPNM_02720	1.65e-102	-	2.7.1.206	-	G	ko:K02813	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIEHEPNM_02721	2.14e-81	-	2.7.1.206	-	G	ko:K02812	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIEHEPNM_02722	6.9e-168	srlD2	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	NAD dependent epimerase/dehydratase family
HIEHEPNM_02723	2.81e-209	-	-	-	K	-	-	-	sugar-binding domain protein
HIEHEPNM_02724	8.47e-304	-	-	-	E	ko:K19956	ko00051,map00051	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
HIEHEPNM_02725	0.0	-	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIEHEPNM_02726	2.62e-198	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_02727	0.0	-	-	-	K	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIEHEPNM_02728	1.77e-198	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_02729	7.36e-159	-	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
HIEHEPNM_02730	1.96e-117	fabG10	1.1.1.100, 1.3.1.28	-	IQ	ko:K00059,ko:K00216	ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01130,ko01212,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	KR domain
HIEHEPNM_02731	4.02e-223	xylB	2.7.1.17, 2.7.1.53	-	G	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the FGGY kinase family
HIEHEPNM_02732	8.81e-49	-	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HIEHEPNM_02733	6.49e-111	-	-	-	G	-	-	-	DeoC/LacD family aldolase
HIEHEPNM_02734	7.44e-153	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
HIEHEPNM_02736	3.88e-271	dcuC	-	-	C	ko:K03326	-	ko00000,ko02000	Tripartite ATP-independent periplasmic transporter, DctM component
HIEHEPNM_02737	7.6e-199	rihC	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
HIEHEPNM_02738	1.1e-112	-	-	-	S	-	-	-	Zeta toxin
HIEHEPNM_02739	6.56e-192	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HIEHEPNM_02740	4.79e-63	-	-	-	-	-	-	-	-
HIEHEPNM_02741	4.22e-287	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIEHEPNM_02742	1.27e-61	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIEHEPNM_02743	8.81e-204	-	-	-	GKT	-	-	-	transcriptional antiterminator
HIEHEPNM_02744	4.94e-40	-	-	-	-	-	-	-	-
HIEHEPNM_02745	7.11e-135	-	-	-	-	-	-	-	-
HIEHEPNM_02746	2.77e-89	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HIEHEPNM_02747	1.78e-152	-	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_02748	4.33e-98	-	-	-	EGP	-	-	-	Major Facilitator
HIEHEPNM_02749	5.52e-121	-	-	-	-	-	-	-	-
HIEHEPNM_02750	7.7e-79	-	-	-	-	-	-	-	-
HIEHEPNM_02751	2.61e-90	-	-	-	-	-	-	-	-
HIEHEPNM_02752	9.81e-111	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HIEHEPNM_02753	3.66e-67	-	-	-	-	-	-	-	-
HIEHEPNM_02754	0.0	pbpC	-	-	M	ko:K21467	-	ko00000,ko01011	NTF2-like N-terminal transpeptidase domain
HIEHEPNM_02755	8.27e-183	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
HIEHEPNM_02760	7.37e-48	-	-	-	-	-	-	-	-
HIEHEPNM_02761	3.31e-58	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
HIEHEPNM_02762	2.71e-209	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIEHEPNM_02763	1.13e-204	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein domain
HIEHEPNM_02764	2.36e-205	rbsC	-	-	U	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIEHEPNM_02765	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HIEHEPNM_02766	2.78e-80	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HIEHEPNM_02767	1.16e-239	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HIEHEPNM_02768	0.0	-	-	-	E	-	-	-	Amino acid permease
HIEHEPNM_02769	4.28e-191	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HIEHEPNM_02770	5.6e-132	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HIEHEPNM_02771	1.14e-193	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HIEHEPNM_02772	1.46e-106	thiW	-	-	S	-	-	-	Thiamine-precursor transporter protein (ThiW)
HIEHEPNM_02773	5.44e-163	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIEHEPNM_02774	1.33e-142	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
HIEHEPNM_02775	1.33e-311	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HIEHEPNM_02776	4.57e-123	-	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
HIEHEPNM_02777	1.11e-49	-	-	-	-	-	-	-	-
HIEHEPNM_02778	6.22e-43	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HIEHEPNM_02779	1.73e-35	-	-	-	T	-	-	-	PFAM SpoVT AbrB
HIEHEPNM_02780	2.8e-105	yvbK	-	-	K	-	-	-	GNAT family
HIEHEPNM_02781	1.84e-147	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
HIEHEPNM_02782	7.6e-131	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HIEHEPNM_02783	1.87e-304	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
HIEHEPNM_02784	2.43e-263	purK2	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIEHEPNM_02785	1.74e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIEHEPNM_02787	1.8e-134	-	-	-	-	-	-	-	-
HIEHEPNM_02788	6.43e-42	-	-	-	-	-	-	-	-