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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
HIFLEHPO_00001	3.39e-88	-	-	-	S	ko:K06915	-	ko00000	cog cog0433
HIFLEHPO_00002	9.86e-146	-	-	-	F	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
HIFLEHPO_00003	8.81e-40	-	-	-	M	-	-	-	Mycoplasma protein of unknown function, DUF285
HIFLEHPO_00005	9.44e-183	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HIFLEHPO_00006	4.95e-164	citG	2.4.2.52	-	H	ko:K05966	ko02020,map02020	ko00000,ko00001,ko01000	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HIFLEHPO_00007	3.11e-250	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
HIFLEHPO_00008	1.28e-226	-	-	-	S	-	-	-	PFAM Archaeal ATPase
HIFLEHPO_00009	1.19e-128	-	-	-	T	-	-	-	Region found in RelA / SpoT proteins
HIFLEHPO_00010	1.52e-135	dltr	-	-	K	-	-	-	response regulator
HIFLEHPO_00011	2.05e-146	sptS	-	-	T	-	-	-	Histidine kinase
HIFLEHPO_00012	2.27e-132	sptS	-	-	T	-	-	-	Histidine kinase
HIFLEHPO_00013	6.74e-267	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIFLEHPO_00014	3.91e-91	-	-	-	O	-	-	-	OsmC-like protein
HIFLEHPO_00015	3.72e-111	yhaH	-	-	S	-	-	-	Protein of unknown function (DUF805)
HIFLEHPO_00016	3.56e-47	-	-	-	-	-	-	-	-
HIFLEHPO_00017	4.13e-83	-	-	-	-	-	-	-	-
HIFLEHPO_00020	7.5e-160	-	-	-	-	-	-	-	-
HIFLEHPO_00021	4.83e-136	pncA	-	-	Q	-	-	-	Isochorismatase family
HIFLEHPO_00022	1.24e-08	-	-	-	-	-	-	-	-
HIFLEHPO_00023	1.73e-48	-	-	-	-	-	-	-	-
HIFLEHPO_00024	5.66e-16	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00025	3.46e-18	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00026	1.32e-86	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00027	1.03e-262	-	-	-	G	-	-	-	Glycosyl hydrolases family 8
HIFLEHPO_00028	3.25e-315	-	-	-	M	-	-	-	Glycosyl transferase
HIFLEHPO_00030	9.39e-195	-	-	-	-	-	-	-	-
HIFLEHPO_00031	6.69e-239	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HIFLEHPO_00032	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIFLEHPO_00033	1.23e-313	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIFLEHPO_00034	3.42e-30	-	-	-	S	-	-	-	HicA toxin of bacterial toxin-antitoxin,
HIFLEHPO_00035	7.19e-281	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HIFLEHPO_00036	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
HIFLEHPO_00037	3.94e-252	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
HIFLEHPO_00038	0.0	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
HIFLEHPO_00039	4.3e-188	-	-	-	S	-	-	-	hydrolase
HIFLEHPO_00040	3.98e-125	-	-	-	S	-	-	-	Phospholipase, patatin family
HIFLEHPO_00041	4.18e-11	-	-	-	-	-	-	-	-
HIFLEHPO_00042	1.02e-75	-	-	-	-	-	-	-	-
HIFLEHPO_00043	6.84e-70	-	-	-	-	-	-	-	-
HIFLEHPO_00045	4.4e-165	-	-	-	S	-	-	-	PAS domain
HIFLEHPO_00046	3.24e-45	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
HIFLEHPO_00047	5.3e-32	-	-	-	-	-	-	-	-
HIFLEHPO_00048	2.48e-226	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HIFLEHPO_00049	9.28e-41	-	-	-	-	-	-	-	-
HIFLEHPO_00050	1.22e-24	-	-	-	-	-	-	-	-
HIFLEHPO_00053	2.12e-27	-	-	-	S	-	-	-	Phage uncharacterised protein (Phage_XkdX)
HIFLEHPO_00054	1.01e-54	-	-	-	-	-	-	-	-
HIFLEHPO_00057	3.95e-17	-	-	-	S	-	-	-	N-acetylmuramoyl-L-alanine amidase activity
HIFLEHPO_00059	4.11e-140	-	-	-	S	-	-	-	Baseplate J-like protein
HIFLEHPO_00060	1.55e-40	-	-	-	-	-	-	-	-
HIFLEHPO_00061	4.1e-49	-	-	-	-	-	-	-	-
HIFLEHPO_00062	2.3e-128	-	-	-	-	-	-	-	-
HIFLEHPO_00063	9.82e-61	-	-	-	-	-	-	-	-
HIFLEHPO_00064	7.64e-54	-	-	-	M	-	-	-	LysM domain
HIFLEHPO_00065	1.18e-225	-	-	-	L	-	-	-	Phage tail tape measure protein TP901
HIFLEHPO_00068	8.17e-168	-	-	-	S	-	-	-	Protein of unknown function (DUF3383)
HIFLEHPO_00071	5.56e-22	-	-	-	-	-	-	-	-
HIFLEHPO_00072	4.47e-35	-	-	-	S	-	-	-	Protein of unknown function (DUF4054)
HIFLEHPO_00074	8.98e-25	-	-	-	-	-	-	-	-
HIFLEHPO_00075	7.53e-73	-	-	-	S	ko:K09960	-	ko00000	Uncharacterized protein conserved in bacteria (DUF2213)
HIFLEHPO_00076	2.38e-28	-	-	-	S	-	-	-	Lysin motif
HIFLEHPO_00077	3.33e-70	-	-	-	S	-	-	-	Phage Mu protein F like protein
HIFLEHPO_00078	2.32e-110	-	-	-	S	ko:K09961	-	ko00000	Protein of unknown function (DUF1073)
HIFLEHPO_00079	4.27e-234	-	-	-	S	-	-	-	Terminase-like family
HIFLEHPO_00082	9.77e-27	-	-	-	S	-	-	-	N-methyltransferase activity
HIFLEHPO_00090	8.55e-49	-	-	-	S	-	-	-	VRR_NUC
HIFLEHPO_00092	7.58e-90	-	-	-	S	-	-	-	ORF6C domain
HIFLEHPO_00097	3.9e-53	-	-	-	Q	-	-	-	methyltransferase
HIFLEHPO_00101	5.95e-24	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
HIFLEHPO_00103	2.6e-21	ansR	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_00104	1.3e-40	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_00105	8.26e-56	-	-	-	S	-	-	-	ERF superfamily
HIFLEHPO_00106	2.49e-67	-	-	-	S	-	-	-	Protein of unknown function (DUF1351)
HIFLEHPO_00109	1.04e-06	-	-	-	K	-	-	-	Tetratricopeptide repeat
HIFLEHPO_00112	2.78e-32	-	-	-	S	-	-	-	Domain of unknown function (DUF771)
HIFLEHPO_00114	3.05e-19	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_00117	2.63e-194	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_00119	2.11e-249	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIFLEHPO_00120	1.82e-97	nrdI	-	-	F	ko:K03647	-	ko00000	NrdI Flavodoxin like
HIFLEHPO_00121	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIFLEHPO_00123	4.26e-108	-	-	-	M	-	-	-	NlpC/P60 family
HIFLEHPO_00124	1.51e-168	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
HIFLEHPO_00125	6.69e-84	-	-	-	L	-	-	-	RelB antitoxin
HIFLEHPO_00126	8.56e-126	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_00127	2.75e-43	-	-	-	G	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HIFLEHPO_00128	0.0	mngB	3.2.1.170	GH38	G	ko:K15524	-	ko00000,ko01000	Glycosyl hydrolases family 38 N-terminal domain
HIFLEHPO_00129	1.48e-84	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00130	0.0	-	-	-	L	-	-	-	Plasmid pRiA4b ORF-3-like protein
HIFLEHPO_00131	2.32e-313	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HIFLEHPO_00132	1.92e-212	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HIFLEHPO_00133	1.44e-164	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HIFLEHPO_00134	1.39e-53	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HIFLEHPO_00135	9.07e-51	-	-	-	S	-	-	-	CRISPR-associated protein (Cas_Csn2)
HIFLEHPO_00136	9.48e-204	-	-	-	S	-	-	-	EDD domain protein, DegV family
HIFLEHPO_00137	2.06e-88	-	-	-	-	-	-	-	-
HIFLEHPO_00138	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
HIFLEHPO_00139	6.15e-36	-	-	-	-	-	-	-	-
HIFLEHPO_00140	5.31e-149	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
HIFLEHPO_00141	3.64e-188	-	2.1.1.172	-	J	ko:K00564,ko:K10716	-	ko00000,ko01000,ko02000,ko03009	Ion channel
HIFLEHPO_00142	1.61e-72	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HIFLEHPO_00143	3.72e-111	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HIFLEHPO_00145	6.45e-291	-	-	-	E	-	-	-	amino acid
HIFLEHPO_00146	6.65e-179	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
HIFLEHPO_00148	1.41e-87	-	-	-	V	-	-	-	HNH endonuclease
HIFLEHPO_00149	3.98e-97	-	-	-	M	-	-	-	LysM domain
HIFLEHPO_00150	3.3e-42	-	-	-	-	-	-	-	-
HIFLEHPO_00152	2.63e-50	-	-	-	-	-	-	-	-
HIFLEHPO_00153	1.25e-143	-	-	-	K	-	-	-	WHG domain
HIFLEHPO_00154	3.41e-125	azo1	1.5.1.36, 1.7.1.6	-	S	ko:K03206,ko:K19784,ko:K22393	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
HIFLEHPO_00155	2.58e-126	azr	1.5.1.36	-	S	ko:K22394	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
HIFLEHPO_00156	9.48e-194	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HIFLEHPO_00157	5.24e-230	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HIFLEHPO_00158	2.99e-75	cvpA	-	-	S	-	-	-	Colicin V production protein
HIFLEHPO_00159	3.66e-166	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
HIFLEHPO_00160	5.86e-191	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HIFLEHPO_00161	4.99e-178	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
HIFLEHPO_00162	4.28e-197	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HIFLEHPO_00163	1.1e-59	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
HIFLEHPO_00164	6.88e-257	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HIFLEHPO_00165	3.93e-176	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
HIFLEHPO_00166	1.22e-190	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_00167	1.68e-179	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_00168	0.0	ndvA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HIFLEHPO_00170	8.32e-157	vanR	-	-	K	-	-	-	response regulator
HIFLEHPO_00171	9.28e-271	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
HIFLEHPO_00172	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIFLEHPO_00173	7.79e-186	racD	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
HIFLEHPO_00174	6.94e-70	-	-	-	S	-	-	-	Enterocin A Immunity
HIFLEHPO_00175	1.95e-45	-	-	-	-	-	-	-	-
HIFLEHPO_00176	1.07e-35	-	-	-	-	-	-	-	-
HIFLEHPO_00177	4.48e-34	-	-	-	-	-	-	-	-
HIFLEHPO_00178	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
HIFLEHPO_00179	0.0	agl	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
HIFLEHPO_00180	0.0	-	-	-	S	ko:K06921	-	ko00000	Archaea bacterial proteins of unknown function
HIFLEHPO_00181	1.89e-23	-	-	-	-	-	-	-	-
HIFLEHPO_00182	7.34e-178	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
HIFLEHPO_00183	2.08e-164	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HIFLEHPO_00184	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HIFLEHPO_00185	4.85e-122	mesE	-	-	M	ko:K12293,ko:K20345	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	Transport protein ComB
HIFLEHPO_00186	5.02e-180	blpT	-	-	-	-	-	-	-
HIFLEHPO_00190	7.87e-30	-	-	-	-	-	-	-	-
HIFLEHPO_00191	4.74e-107	-	-	-	-	-	-	-	-
HIFLEHPO_00192	6.32e-42	-	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
HIFLEHPO_00193	2.52e-32	-	-	-	-	-	-	-	-
HIFLEHPO_00194	3.41e-88	-	-	-	-	-	-	-	-
HIFLEHPO_00195	3.09e-212	natA	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_00196	6.39e-279	natB	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIFLEHPO_00197	3.14e-175	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
HIFLEHPO_00198	2.18e-215	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HIFLEHPO_00199	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase System
HIFLEHPO_00200	4.47e-56	-	-	-	K	ko:K21903	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
HIFLEHPO_00201	2.43e-209	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HIFLEHPO_00202	1.63e-152	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HIFLEHPO_00203	1.59e-172	znuB	-	-	U	ko:K02075,ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
HIFLEHPO_00204	5.22e-05	-	-	-	-	-	-	-	-
HIFLEHPO_00205	2.75e-96	-	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
HIFLEHPO_00206	3.74e-125	-	-	-	-	-	-	-	-
HIFLEHPO_00207	5.34e-143	crt	4.2.1.17	-	I	ko:K01715	ko00650,ko01200,map00650,map01200	ko00000,ko00001,ko01000	Enoyl-CoA hydratase/isomerase
HIFLEHPO_00208	5.89e-192	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Nitronate monooxygenase
HIFLEHPO_00209	4.7e-183	pct	2.8.3.1	-	I	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	ko00000,ko00001,ko01000	Coenzyme A transferase
HIFLEHPO_00210	3.82e-294	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HIFLEHPO_00211	3.31e-154	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HIFLEHPO_00212	1.64e-45	-	-	-	-	-	-	-	-
HIFLEHPO_00215	1.84e-263	-	4.2.1.126	-	S	ko:K07106,ko:K09963	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Bacterial protein of unknown function (DUF871)
HIFLEHPO_00216	5.12e-242	asnA	6.3.1.1	-	F	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
HIFLEHPO_00219	4.26e-27	-	-	-	E	-	-	-	Pfam:DUF955
HIFLEHPO_00220	8.25e-16	-	-	-	S	-	-	-	Protein conserved in bacteria
HIFLEHPO_00222	2.72e-05	-	-	-	M	ko:K11021	-	ko00000,ko02042	COG3209 Rhs family protein
HIFLEHPO_00223	4.73e-32	-	-	-	S	-	-	-	Domain of unknown function (DUF4417)
HIFLEHPO_00224	1.91e-233	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HIFLEHPO_00226	7.57e-190	-	-	-	S	ko:K09704	-	ko00000	Metal-independent alpha-mannosidase (GH125)
HIFLEHPO_00227	2.16e-193	-	2.3.1.81	-	V	ko:K00662	-	ko00000,ko01000,ko01504	Aminoglycoside 3-N-acetyltransferase
HIFLEHPO_00228	6.64e-185	-	-	-	F	-	-	-	Phosphorylase superfamily
HIFLEHPO_00229	1.05e-176	-	-	-	F	-	-	-	Phosphorylase superfamily
HIFLEHPO_00230	2.05e-96	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
HIFLEHPO_00231	7.12e-100	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HIFLEHPO_00232	1.87e-104	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HIFLEHPO_00233	1.08e-69	-	-	-	L	-	-	-	Transposase and inactivated derivatives
HIFLEHPO_00234	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HIFLEHPO_00235	5.41e-172	cysA	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_00236	2.1e-31	-	-	-	-	-	-	-	-
HIFLEHPO_00237	1.69e-06	-	-	-	-	-	-	-	-
HIFLEHPO_00238	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIFLEHPO_00239	1.72e-228	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HIFLEHPO_00240	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
HIFLEHPO_00241	2.8e-160	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HIFLEHPO_00242	0.0	oppA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_00243	4.14e-154	oppC5	-	-	P	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_00244	1.49e-225	oppB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_00245	4.31e-231	oppF	-	-	P	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_00246	5.15e-247	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_00247	4.4e-47	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIFLEHPO_00248	3.69e-233	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HIFLEHPO_00249	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIFLEHPO_00250	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
HIFLEHPO_00251	8.29e-75	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HIFLEHPO_00252	1.33e-35	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
HIFLEHPO_00253	2.29e-41	-	-	-	-	-	-	-	-
HIFLEHPO_00254	9.44e-161	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
HIFLEHPO_00255	7.49e-154	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HIFLEHPO_00256	1.71e-208	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HIFLEHPO_00257	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HIFLEHPO_00258	3.28e-179	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
HIFLEHPO_00259	1.84e-309	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HIFLEHPO_00260	5.15e-219	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HIFLEHPO_00261	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIFLEHPO_00262	2.37e-46	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HIFLEHPO_00263	5.97e-145	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
HIFLEHPO_00264	2.19e-100	-	-	-	S	-	-	-	ASCH
HIFLEHPO_00265	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
HIFLEHPO_00266	7.22e-197	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
HIFLEHPO_00267	6.44e-205	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HIFLEHPO_00268	1.53e-47	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HIFLEHPO_00269	1.97e-248	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HIFLEHPO_00270	7.19e-199	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HIFLEHPO_00271	2.78e-85	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HIFLEHPO_00272	7.98e-93	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
HIFLEHPO_00273	2.11e-133	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIFLEHPO_00274	2.14e-257	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HIFLEHPO_00275	3.94e-64	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
HIFLEHPO_00276	6.82e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
HIFLEHPO_00277	5.24e-194	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIFLEHPO_00278	0.0	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
HIFLEHPO_00279	1.28e-168	-	-	-	L	-	-	-	PFAM transposase IS116 IS110 IS902
HIFLEHPO_00280	8.6e-128	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HIFLEHPO_00281	0.0	cas9	-	-	L	ko:K09952	-	ko00000,ko01000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HIFLEHPO_00282	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
HIFLEHPO_00283	4.52e-29	-	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_00284	0.0	-	-	-	S	-	-	-	Predicted membrane protein (DUF2207)
HIFLEHPO_00285	2.07e-38	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
HIFLEHPO_00287	5.69e-179	msmE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_00288	1.14e-208	-	-	-	K	ko:K03484	-	ko00000,ko03000	Periplasmic binding protein domain
HIFLEHPO_00289	2.14e-48	-	-	-	-	-	-	-	-
HIFLEHPO_00290	9.82e-80	-	-	-	F	-	-	-	NUDIX domain
HIFLEHPO_00291	1.83e-103	-	-	-	S	-	-	-	AAA domain
HIFLEHPO_00292	1.5e-150	-	-	-	S	-	-	-	F420-0:Gamma-glutamyl ligase
HIFLEHPO_00293	8.99e-59	yxaM	-	-	EGP	-	-	-	Major facilitator Superfamily
HIFLEHPO_00294	2e-299	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIFLEHPO_00295	1.23e-125	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
HIFLEHPO_00296	9e-132	-	-	-	L	-	-	-	Integrase
HIFLEHPO_00297	1.64e-90	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	Toxin-antitoxin system, toxin component, MazF family
HIFLEHPO_00298	5.32e-42	-	-	-	-	ko:K18829	-	ko00000,ko02048	-
HIFLEHPO_00299	6.59e-115	-	-	-	-	-	-	-	-
HIFLEHPO_00300	4.95e-98	-	-	-	-	-	-	-	-
HIFLEHPO_00301	6.48e-167	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00303	3.92e-153	-	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
HIFLEHPO_00304	1.37e-287	-	-	-	I	-	-	-	Protein of unknown function (DUF2974)
HIFLEHPO_00305	2.26e-31	-	-	-	S	-	-	-	Transglycosylase associated protein
HIFLEHPO_00306	3.81e-18	-	-	-	S	-	-	-	CsbD-like
HIFLEHPO_00307	4.76e-213	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
HIFLEHPO_00308	1.23e-170	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_00309	2.26e-215	degV1	-	-	S	-	-	-	DegV family
HIFLEHPO_00310	5.56e-217	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, phosphonate, periplasmic substrate-binding protein
HIFLEHPO_00311	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HIFLEHPO_00312	3.87e-97	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HIFLEHPO_00313	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
HIFLEHPO_00314	1.89e-47	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HIFLEHPO_00315	4.83e-104	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HIFLEHPO_00316	6.72e-66	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
HIFLEHPO_00317	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIFLEHPO_00318	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIFLEHPO_00319	4.22e-267	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HIFLEHPO_00320	1.13e-48	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
HIFLEHPO_00321	8.11e-245	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HIFLEHPO_00322	9.14e-317	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HIFLEHPO_00323	7.67e-252	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00324	3.26e-23	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
HIFLEHPO_00325	2.65e-81	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HIFLEHPO_00326	3.37e-192	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIFLEHPO_00327	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HIFLEHPO_00328	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HIFLEHPO_00329	0.0	pox1	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HIFLEHPO_00330	5.38e-39	-	-	-	-	-	-	-	-
HIFLEHPO_00331	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HIFLEHPO_00332	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HIFLEHPO_00333	1.98e-41	-	-	-	E	-	-	-	Zn peptidase
HIFLEHPO_00334	8.29e-76	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00335	2.35e-58	-	-	-	-	-	-	-	-
HIFLEHPO_00336	1.06e-133	-	-	-	S	-	-	-	Bacteriocin helveticin-J
HIFLEHPO_00337	1.14e-154	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_00338	6.57e-175	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_00339	1.12e-268	-	-	-	-	-	-	-	-
HIFLEHPO_00340	6.46e-27	-	-	-	-	-	-	-	-
HIFLEHPO_00341	2.71e-222	-	-	-	EGP	ko:K08368	-	ko00000,ko02000	Sugar (and other) transporter
HIFLEHPO_00342	4.01e-84	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
HIFLEHPO_00343	5.51e-46	-	-	-	S	-	-	-	Transposase C of IS166 homeodomain
HIFLEHPO_00344	1.28e-311	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
HIFLEHPO_00345	7.23e-50	-	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
HIFLEHPO_00346	1.8e-222	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_00347	2.92e-79	-	-	-	-	-	-	-	-
HIFLEHPO_00348	0.0	celD	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_00349	1.66e-44	-	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_00350	1.12e-213	-	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00351	5.52e-49	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HIFLEHPO_00352	3.01e-73	-	-	-	-	-	-	-	-
HIFLEHPO_00353	2.31e-77	-	-	-	GK	-	-	-	ROK family
HIFLEHPO_00354	5.01e-55	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
HIFLEHPO_00355	4.39e-268	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HIFLEHPO_00356	1.28e-162	sagD	-	-	S	-	-	-	YcaO cyclodehydratase, ATP-ad Mg2+-binding
HIFLEHPO_00358	2.78e-70	-	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
HIFLEHPO_00359	7.02e-36	-	-	-	-	-	-	-	-
HIFLEHPO_00360	1.32e-105	-	-	-	S	-	-	-	PFAM Archaeal ATPase
HIFLEHPO_00361	8.08e-108	-	-	-	S	-	-	-	PFAM Archaeal ATPase
HIFLEHPO_00362	2.58e-45	-	-	-	-	-	-	-	-
HIFLEHPO_00363	7.14e-91	-	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00364	1.9e-185	-	-	-	D	-	-	-	domain protein
HIFLEHPO_00369	9.66e-39	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
HIFLEHPO_00372	5.72e-108	-	-	-	S	-	-	-	Phage capsid family
HIFLEHPO_00373	2.3e-70	-	-	-	OU	-	-	-	Belongs to the peptidase S14 family
HIFLEHPO_00374	5.61e-125	-	-	-	S	-	-	-	Phage portal protein
HIFLEHPO_00376	2.77e-220	terL	-	-	S	-	-	-	overlaps another CDS with the same product name
HIFLEHPO_00377	0.000922	-	-	-	S	-	-	-	Phage terminase, small subunit
HIFLEHPO_00379	3.49e-48	-	-	-	L	-	-	-	HNH endonuclease
HIFLEHPO_00388	3.93e-20	-	-	-	S	-	-	-	HNH endonuclease
HIFLEHPO_00389	1.85e-12	-	-	-	-	-	-	-	-
HIFLEHPO_00392	2.73e-103	-	-	-	V	-	-	-	site-specific DNA-methyltransferase (adenine-specific) activity
HIFLEHPO_00393	1.75e-104	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_00397	2.38e-28	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
HIFLEHPO_00404	8.17e-84	-	-	-	K	-	-	-	Peptidase S24-like
HIFLEHPO_00405	1.64e-73	-	-	-	V	-	-	-	Abi-like protein
HIFLEHPO_00407	6.69e-155	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_00408	4.88e-12	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIFLEHPO_00410	2.83e-205	yitT	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIFLEHPO_00411	3.06e-140	-	-	-	-	-	-	-	-
HIFLEHPO_00412	3.06e-202	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HIFLEHPO_00413	2.95e-283	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
HIFLEHPO_00414	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
HIFLEHPO_00415	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HIFLEHPO_00416	6.83e-133	yrgI	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Histidine phosphatase superfamily (branch 1)
HIFLEHPO_00417	0.0	-	-	-	L	-	-	-	PLD-like domain
HIFLEHPO_00418	5.97e-55	-	-	-	S	-	-	-	SnoaL-like domain
HIFLEHPO_00419	6.13e-70	-	-	-	K	-	-	-	sequence-specific DNA binding
HIFLEHPO_00420	8.71e-31	-	-	-	G	-	-	-	Ribose/Galactose Isomerase
HIFLEHPO_00421	5.51e-35	-	-	-	-	-	-	-	-
HIFLEHPO_00422	9.13e-157	-	-	-	L	-	-	-	PFAM transposase IS116 IS110 IS902
HIFLEHPO_00423	2.99e-114	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HIFLEHPO_00425	1.27e-42	-	-	-	K	-	-	-	Bacterial regulatory helix-turn-helix protein, lysR family
HIFLEHPO_00426	3.24e-290	-	-	-	L	-	-	-	COG3547 Transposase and inactivated derivatives
HIFLEHPO_00427	1.44e-07	-	-	-	S	-	-	-	YSIRK type signal peptide
HIFLEHPO_00429	3.52e-296	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
HIFLEHPO_00430	7.55e-53	-	-	-	S	-	-	-	Transglycosylase associated protein
HIFLEHPO_00431	7.7e-126	-	-	-	L	-	-	-	Helix-turn-helix domain
HIFLEHPO_00433	1.22e-98	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HIFLEHPO_00434	1.7e-69	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HIFLEHPO_00435	2.91e-217	mprF	-	-	S	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HIFLEHPO_00436	9.03e-257	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HIFLEHPO_00437	1.72e-286	-	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyl transferase 4-like domain
HIFLEHPO_00449	1.14e-28	-	-	-	-	-	-	-	-
HIFLEHPO_00455	6.01e-66	-	-	-	-	-	-	-	-
HIFLEHPO_00459	1.51e-76	-	-	-	-	-	-	-	-
HIFLEHPO_00460	6.65e-45	-	-	-	-	-	-	-	-
HIFLEHPO_00462	2.46e-207	-	-	-	S	-	-	-	Baseplate J-like protein
HIFLEHPO_00464	1.61e-58	-	-	-	-	-	-	-	-
HIFLEHPO_00465	1.43e-143	-	-	-	-	-	-	-	-
HIFLEHPO_00466	9.3e-57	-	-	-	-	-	-	-	-
HIFLEHPO_00467	4.47e-105	-	-	-	M	-	-	-	LysM domain
HIFLEHPO_00468	6.98e-273	-	-	-	L	-	-	-	Phage tail tape measure protein TP901
HIFLEHPO_00472	4.04e-147	-	-	-	S	-	-	-	Protein of unknown function (DUF3383)
HIFLEHPO_00475	9.75e-36	-	-	-	-	-	-	-	-
HIFLEHPO_00478	8.2e-45	-	-	-	-	-	-	-	-
HIFLEHPO_00479	2.04e-78	-	-	-	S	ko:K09960	-	ko00000	Uncharacterized protein conserved in bacteria (DUF2213)
HIFLEHPO_00480	4.13e-28	-	-	-	S	-	-	-	Lysin motif
HIFLEHPO_00481	4.88e-85	-	-	-	S	-	-	-	Phage Mu protein F like protein
HIFLEHPO_00482	4.55e-138	-	-	-	S	ko:K09961	-	ko00000	Protein of unknown function (DUF1073)
HIFLEHPO_00483	1.36e-248	-	-	-	S	-	-	-	Terminase-like family
HIFLEHPO_00484	2.92e-26	-	-	-	L	ko:K07474	-	ko00000	Terminase small subunit
HIFLEHPO_00486	1.75e-20	bcgIA	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	site-specific DNA-methyltransferase (adenine-specific) activity
HIFLEHPO_00487	1.97e-88	-	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	site-specific DNA-methyltransferase (adenine-specific) activity
HIFLEHPO_00492	4.36e-272	XK27_11280	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HIFLEHPO_00494	6.94e-54	-	-	-	S	-	-	-	VRR_NUC
HIFLEHPO_00496	2.15e-127	-	-	-	L	-	-	-	Helix-turn-helix domain
HIFLEHPO_00497	2.18e-51	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_00498	2.75e-107	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00499	9.62e-25	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00502	2.61e-30	-	-	-	-	-	-	-	-
HIFLEHPO_00503	1.31e-231	-	-	-	S	ko:K07133	-	ko00000	cog cog1373
HIFLEHPO_00504	3.74e-180	-	-	-	L	-	-	-	Transposase DDE domain
HIFLEHPO_00505	2.37e-190	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
HIFLEHPO_00506	6.59e-160	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
HIFLEHPO_00507	5.28e-215	-	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HIFLEHPO_00508	3.53e-63	hxlB	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
HIFLEHPO_00509	1.55e-82	-	-	-	M	-	-	-	SIS domain
HIFLEHPO_00510	8.46e-98	-	-	-	S	-	-	-	Uncharacterised protein family UPF0047
HIFLEHPO_00511	1.88e-44	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIFLEHPO_00512	3.94e-254	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIFLEHPO_00513	3.05e-53	-	2.7.1.200	-	GT	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_00514	2.39e-85	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HIFLEHPO_00515	2.76e-188	-	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
HIFLEHPO_00516	1.92e-90	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HIFLEHPO_00518	2.94e-94	-	-	-	S	-	-	-	Bacterial transferase hexapeptide (six repeats)
HIFLEHPO_00519	5.18e-109	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HIFLEHPO_00520	2.56e-66	-	-	-	M	-	-	-	Domain of unknown function (DUF1919)
HIFLEHPO_00521	2.38e-130	-	-	GT4	M	ko:K19424	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HIFLEHPO_00522	2.82e-97	-	-	-	S	-	-	-	Glycosyltransferase family 28 C-terminal domain
HIFLEHPO_00523	1.53e-102	-	-	-	M	-	-	-	Oligosaccharide biosynthesis protein Alg14 like
HIFLEHPO_00524	5.25e-137	-	-	-	M	-	-	-	Glycosyltransferase
HIFLEHPO_00525	6.23e-40	-	-	-	M	-	-	-	Glycosyltransferase
HIFLEHPO_00526	6.65e-155	epsE2	-	-	M	-	-	-	Bacterial sugar transferase
HIFLEHPO_00527	6.64e-186	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
HIFLEHPO_00528	2.78e-160	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
HIFLEHPO_00529	4.34e-184	epsB	-	-	M	-	-	-	biosynthesis protein
HIFLEHPO_00530	1.47e-243	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIFLEHPO_00534	1.3e-282	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIFLEHPO_00535	1.26e-223	-	-	-	S	-	-	-	Cysteine-rich secretory protein family
HIFLEHPO_00536	3.01e-54	-	-	-	-	-	-	-	-
HIFLEHPO_00537	1.73e-167	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC/P60 family
HIFLEHPO_00538	1.28e-174	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
HIFLEHPO_00539	4.39e-116	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC/P60 family
HIFLEHPO_00540	2.11e-115	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase homologues.
HIFLEHPO_00541	4.52e-56	-	-	-	-	-	-	-	-
HIFLEHPO_00542	0.0	-	-	-	S	-	-	-	O-antigen ligase like membrane protein
HIFLEHPO_00543	8.77e-144	-	-	-	-	-	-	-	-
HIFLEHPO_00544	6.96e-286	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIFLEHPO_00545	4.75e-101	nrdI	-	-	F	ko:K03647	-	ko00000	NrdI Flavodoxin like
HIFLEHPO_00546	3.4e-227	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIFLEHPO_00547	1.16e-101	-	-	-	-	-	-	-	-
HIFLEHPO_00548	2.72e-144	-	-	-	S	-	-	-	Peptidase_C39 like family
HIFLEHPO_00549	7.36e-109	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HIFLEHPO_00550	7.35e-174	-	-	-	S	-	-	-	Putative threonine/serine exporter
HIFLEHPO_00551	0.0	-	-	-	S	-	-	-	ABC transporter
HIFLEHPO_00552	1.64e-81	-	-	-	-	-	-	-	-
HIFLEHPO_00553	1.1e-125	rimL	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HIFLEHPO_00554	2.8e-160	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
HIFLEHPO_00555	7.9e-272	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIFLEHPO_00556	3.01e-210	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_00557	1.55e-09	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
HIFLEHPO_00558	3.85e-180	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
HIFLEHPO_00559	1.29e-115	-	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00560	5.98e-119	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_00561	1.26e-62	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_00562	4.3e-175	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HIFLEHPO_00563	3.1e-92	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal
HIFLEHPO_00564	2.86e-287	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIFLEHPO_00565	3.52e-272	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HIFLEHPO_00566	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HIFLEHPO_00567	3.07e-142	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HIFLEHPO_00568	8.08e-110	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HIFLEHPO_00569	1.47e-302	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HIFLEHPO_00570	1.35e-56	-	-	-	-	-	-	-	-
HIFLEHPO_00571	9.45e-104	uspA	-	-	T	-	-	-	universal stress protein
HIFLEHPO_00572	1.18e-275	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
HIFLEHPO_00573	5.13e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
HIFLEHPO_00574	1.59e-68	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
HIFLEHPO_00575	4.81e-227	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
HIFLEHPO_00576	2.54e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF1146)
HIFLEHPO_00577	2.45e-93	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
HIFLEHPO_00578	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HIFLEHPO_00579	1.48e-221	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HIFLEHPO_00580	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HIFLEHPO_00581	6.55e-120	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIFLEHPO_00582	2.48e-83	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HIFLEHPO_00583	4.83e-37	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIFLEHPO_00584	5.87e-166	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
HIFLEHPO_00585	5.28e-146	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HIFLEHPO_00586	1.66e-243	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HIFLEHPO_00587	1.24e-198	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HIFLEHPO_00588	6.6e-237	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HIFLEHPO_00589	7.02e-146	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
HIFLEHPO_00590	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Domain of unknown function (DUF1727)
HIFLEHPO_00593	7.95e-250	ampC	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_00594	3.26e-274	-	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00595	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
HIFLEHPO_00596	5.3e-137	vanZ	-	-	V	-	-	-	VanZ like family
HIFLEHPO_00597	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HIFLEHPO_00598	0.0	yclK	-	-	T	-	-	-	Histidine kinase
HIFLEHPO_00599	4.96e-167	-	-	-	K	-	-	-	Transcriptional regulatory protein, C terminal
HIFLEHPO_00600	9.01e-90	-	-	-	S	-	-	-	SdpI/YhfL protein family
HIFLEHPO_00601	1.93e-242	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HIFLEHPO_00602	1.72e-288	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
HIFLEHPO_00603	1.72e-127	-	-	-	M	-	-	-	Protein of unknown function (DUF3737)
HIFLEHPO_00605	1e-22	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3850)
HIFLEHPO_00606	1.7e-101	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HIFLEHPO_00608	1.07e-153	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	NUDIX domain
HIFLEHPO_00609	1.35e-191	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HIFLEHPO_00612	1.72e-285	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HIFLEHPO_00613	5.03e-313	mdr	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00614	0.0	pts32BC	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIFLEHPO_00615	1.54e-194	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HIFLEHPO_00616	7.56e-225	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Beta-lactamase
HIFLEHPO_00617	5.06e-237	-	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HIFLEHPO_00618	3.22e-185	-	-	-	K	-	-	-	rpiR family
HIFLEHPO_00619	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
HIFLEHPO_00620	4.87e-236	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
HIFLEHPO_00621	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HIFLEHPO_00622	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HIFLEHPO_00623	1.76e-165	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HIFLEHPO_00624	7.38e-168	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HIFLEHPO_00625	4e-204	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HIFLEHPO_00626	1.74e-293	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HIFLEHPO_00627	3.16e-52	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
HIFLEHPO_00628	2.82e-110	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_00629	6.75e-216	-	-	-	K	-	-	-	LysR substrate binding domain
HIFLEHPO_00630	1.39e-156	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
HIFLEHPO_00631	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
HIFLEHPO_00632	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HIFLEHPO_00633	2.52e-151	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_00634	2.96e-42	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_00635	4.84e-42	-	-	-	-	-	-	-	-
HIFLEHPO_00636	9.14e-187	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HIFLEHPO_00637	8.73e-205	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HIFLEHPO_00638	8.63e-195	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HIFLEHPO_00639	4.66e-179	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIFLEHPO_00640	8.62e-138	-	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HIFLEHPO_00641	1.56e-155	phoB	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
HIFLEHPO_00642	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIFLEHPO_00644	2.84e-108	-	-	-	K	-	-	-	FR47-like protein
HIFLEHPO_00645	3.24e-112	yxaM	-	-	EGP	-	-	-	Major facilitator Superfamily
HIFLEHPO_00646	6.13e-110	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIFLEHPO_00647	4.34e-166	-	-	-	S	-	-	-	Peptidase family M23
HIFLEHPO_00648	5.37e-106	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
HIFLEHPO_00649	2.8e-159	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
HIFLEHPO_00650	8.12e-196	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HIFLEHPO_00651	3.02e-151	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HIFLEHPO_00652	4.97e-122	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HIFLEHPO_00653	1.25e-80	lexA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator, GntR family
HIFLEHPO_00654	1.33e-161	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIFLEHPO_00655	1.65e-180	-	-	-	-	-	-	-	-
HIFLEHPO_00656	2.54e-176	-	-	-	-	-	-	-	-
HIFLEHPO_00657	3.85e-193	-	-	-	-	-	-	-	-
HIFLEHPO_00658	3.49e-36	-	-	-	-	-	-	-	-
HIFLEHPO_00659	1.27e-133	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HIFLEHPO_00660	4.68e-183	-	-	-	-	-	-	-	-
HIFLEHPO_00661	4.4e-215	-	-	-	-	-	-	-	-
HIFLEHPO_00662	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
HIFLEHPO_00663	1.28e-150	-	3.1.3.102, 3.1.3.104, 3.1.3.23	-	G	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
HIFLEHPO_00664	4.87e-236	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HIFLEHPO_00665	6.67e-261	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
HIFLEHPO_00666	5.87e-228	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
HIFLEHPO_00667	2.12e-173	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	GHMP kinases N terminal domain
HIFLEHPO_00668	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HIFLEHPO_00669	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
HIFLEHPO_00670	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
HIFLEHPO_00671	9.62e-116	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
HIFLEHPO_00672	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
HIFLEHPO_00673	6.91e-149	dnaD	-	-	L	ko:K02086	-	ko00000	DnaD domain protein
HIFLEHPO_00674	1.92e-148	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIFLEHPO_00675	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
HIFLEHPO_00676	8.47e-152	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HIFLEHPO_00677	1.18e-139	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
HIFLEHPO_00678	1.85e-90	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HIFLEHPO_00679	6.85e-277	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
HIFLEHPO_00680	6.74e-309	cpdA	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIFLEHPO_00681	9.67e-104	-	-	-	-	-	-	-	-
HIFLEHPO_00682	9.91e-150	-	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Ham1 family
HIFLEHPO_00683	1.33e-22	-	-	-	S	-	-	-	PemK-like, MazF-like toxin of type II toxin-antitoxin system
HIFLEHPO_00684	1.69e-31	-	-	-	L	ko:K07473	-	ko00000,ko02048	Addiction module antitoxin, RelB DinJ family
HIFLEHPO_00685	4.16e-55	-	-	-	E	-	-	-	Pfam:DUF955
HIFLEHPO_00687	2.63e-24	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
HIFLEHPO_00688	1.72e-33	-	-	-	L	-	-	-	four-way junction helicase activity
HIFLEHPO_00697	2.23e-24	lysM	-	-	M	-	-	-	LysM domain
HIFLEHPO_00698	3.25e-194	-	-	-	S	-	-	-	COG0433 Predicted ATPase
HIFLEHPO_00702	1.14e-163	-	-	-	U	ko:K03205	ko03070,map03070	ko00000,ko00001,ko00002,ko02044	TraM recognition site of TraD and TraG
HIFLEHPO_00707	3.76e-13	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_00708	6.55e-05	-	-	-	M	-	-	-	Conserved repeat domain
HIFLEHPO_00709	2.46e-10	-	-	-	M	-	-	-	oxidoreductase activity
HIFLEHPO_00711	3.61e-20	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HIFLEHPO_00712	2.48e-15	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_00716	2.59e-10	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HIFLEHPO_00724	2.38e-32	-	-	-	S	-	-	-	Domain of unknown function (DUF771)
HIFLEHPO_00725	9.39e-39	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_00726	5.58e-33	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00727	3.74e-20	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HIFLEHPO_00729	2.63e-194	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_00731	1.07e-281	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIFLEHPO_00732	4.37e-241	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
HIFLEHPO_00733	3.69e-30	-	-	-	-	-	-	-	-
HIFLEHPO_00734	1.31e-98	-	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Putative Competence protein ComGF
HIFLEHPO_00735	1.96e-54	-	-	-	-	-	-	-	-
HIFLEHPO_00736	8.52e-93	-	-	-	-	ko:K02246	-	ko00000,ko00002,ko02044	-
HIFLEHPO_00737	7.88e-63	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	competence protein ComGC
HIFLEHPO_00738	5.15e-224	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
HIFLEHPO_00739	5.04e-231	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
HIFLEHPO_00740	5.65e-171	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
HIFLEHPO_00741	3.31e-120	-	-	-	S	-	-	-	VanZ like family
HIFLEHPO_00742	7.83e-140	ylbE	-	-	GM	-	-	-	NAD(P)H-binding
HIFLEHPO_00743	4.8e-38	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIFLEHPO_00745	0.0	-	-	-	E	-	-	-	Amino acid permease
HIFLEHPO_00746	5.92e-235	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HIFLEHPO_00747	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIFLEHPO_00748	0.0	pts33BCA	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIFLEHPO_00749	8.39e-195	bglG5	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
HIFLEHPO_00750	1.25e-262	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
HIFLEHPO_00751	3.07e-112	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIFLEHPO_00752	2.85e-153	-	-	-	-	-	-	-	-
HIFLEHPO_00753	3.23e-98	copY	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Penicillinase repressor
HIFLEHPO_00754	8.04e-190	-	-	-	S	-	-	-	hydrolase
HIFLEHPO_00755	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIFLEHPO_00756	2.76e-221	ybbR	-	-	S	-	-	-	YbbR-like protein
HIFLEHPO_00757	2.13e-194	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HIFLEHPO_00758	3.46e-266	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_00759	3.69e-170	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_00760	8.77e-173	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_00761	1.25e-263	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HIFLEHPO_00762	2.84e-208	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
HIFLEHPO_00763	1.51e-127	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HIFLEHPO_00764	4.82e-113	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
HIFLEHPO_00765	1.1e-232	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
HIFLEHPO_00766	1.64e-174	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HIFLEHPO_00767	2.81e-200	ycsE	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIFLEHPO_00768	3.07e-124	-	-	-	-	-	-	-	-
HIFLEHPO_00769	6.12e-94	-	-	-	L	-	-	-	COG2826 Transposase and inactivated derivatives, IS30 family
HIFLEHPO_00771	0.0	-	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
HIFLEHPO_00772	1.46e-117	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIFLEHPO_00773	0.0	qacA	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_00778	1.42e-122	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIFLEHPO_00779	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HIFLEHPO_00780	5.63e-254	flp	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_00781	7.58e-291	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
HIFLEHPO_00782	1.64e-65	-	-	-	-	-	-	-	-
HIFLEHPO_00783	4.83e-144	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
HIFLEHPO_00784	4.45e-84	-	-	-	K	-	-	-	transcriptional regulator
HIFLEHPO_00786	3.93e-219	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
HIFLEHPO_00787	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIFLEHPO_00788	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HIFLEHPO_00789	5.42e-67	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIFLEHPO_00790	6.25e-268	camS	-	-	S	-	-	-	sex pheromone
HIFLEHPO_00791	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HIFLEHPO_00792	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
HIFLEHPO_00793	3.29e-127	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
HIFLEHPO_00795	2.24e-110	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
HIFLEHPO_00796	5.48e-173	-	-	-	M	-	-	-	Glycosyltransferase sugar-binding region containing DXD motif
HIFLEHPO_00797	0.0	epsU	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HIFLEHPO_00798	9.16e-287	-	-	-	M	-	-	-	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HIFLEHPO_00799	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HIFLEHPO_00800	4e-260	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIFLEHPO_00801	1.91e-195	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HIFLEHPO_00802	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HIFLEHPO_00803	2.94e-261	-	-	-	M	-	-	-	Glycosyl transferases group 1
HIFLEHPO_00804	2.13e-171	tagA	2.4.1.187	GT26	F	ko:K05946	ko05111,map05111	ko00000,ko00001,ko01000,ko01003	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HIFLEHPO_00805	8.89e-57	sagB	-	-	C	-	-	-	Nitroreductase family
HIFLEHPO_00806	1.25e-17	-	-	-	-	-	-	-	-
HIFLEHPO_00807	2.77e-220	pphA	3.1.3.16	-	T	ko:K07313	-	ko00000,ko01000	Calcineurin-like phosphoesterase
HIFLEHPO_00808	1.04e-41	-	-	-	-	-	-	-	-
HIFLEHPO_00810	3.65e-90	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HIFLEHPO_00811	1.08e-145	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
HIFLEHPO_00812	4.51e-77	psiE	-	-	S	ko:K13256	-	ko00000	Phosphate-starvation-inducible E
HIFLEHPO_00814	6.58e-175	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
HIFLEHPO_00815	1.49e-290	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
HIFLEHPO_00816	7.82e-80	-	-	-	-	-	-	-	-
HIFLEHPO_00817	0.0	-	-	-	L	ko:K03724	-	ko00000,ko01000,ko03400	DEAD DEAH box helicase
HIFLEHPO_00818	4.13e-310	-	-	-	P	-	-	-	P-loop Domain of unknown function (DUF2791)
HIFLEHPO_00819	0.0	-	-	-	S	-	-	-	TerB-C domain
HIFLEHPO_00820	0.0	pckA	4.1.1.49	-	H	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Phosphoenolpyruvate carboxykinase
HIFLEHPO_00821	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIFLEHPO_00822	6.94e-202	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_00823	9.05e-78	apfA	3.6.1.61	-	F	ko:K18445	ko00230,map00230	ko00000,ko00001,ko01000	Nudix hydrolase
HIFLEHPO_00824	3.36e-42	-	-	-	-	-	-	-	-
HIFLEHPO_00825	2.53e-100	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
HIFLEHPO_00826	5.26e-36	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
HIFLEHPO_00827	2.7e-277	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
HIFLEHPO_00828	5.75e-103	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_00829	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIFLEHPO_00830	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	Mga helix-turn-helix domain
HIFLEHPO_00831	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HIFLEHPO_00832	1.14e-144	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
HIFLEHPO_00833	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
HIFLEHPO_00834	1.38e-309	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HIFLEHPO_00835	7.06e-111	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
HIFLEHPO_00836	3.57e-204	-	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_00837	1.31e-81	-	-	-	S	-	-	-	Domain of unknown function (DUF956)
HIFLEHPO_00838	3.51e-222	manN	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HIFLEHPO_00839	9.65e-181	manY	-	-	G	ko:K02746,ko:K02795	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system
HIFLEHPO_00840	4.5e-235	manL	2.7.1.191	-	G	ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIFLEHPO_00842	9.23e-106	-	-	-	L	-	-	-	PFAM Transposase DDE domain
HIFLEHPO_00843	2.09e-110	-	-	-	-	-	-	-	-
HIFLEHPO_00845	3.79e-175	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
HIFLEHPO_00846	7.36e-135	-	-	-	C	-	-	-	Flavodoxin
HIFLEHPO_00847	2.27e-191	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	prohibitin homologues
HIFLEHPO_00848	1.8e-66	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
HIFLEHPO_00849	2.39e-26	-	-	-	-	-	-	-	-
HIFLEHPO_00850	1.79e-245	-	-	-	S	-	-	-	Bacteriocin helveticin-J
HIFLEHPO_00851	1.86e-197	-	-	-	M	-	-	-	Peptidase family M1 domain
HIFLEHPO_00852	9.84e-108	-	-	-	L	-	-	-	Resolvase, N-terminal
HIFLEHPO_00853	4.5e-107	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIFLEHPO_00854	4.2e-93	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIFLEHPO_00855	7.29e-220	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_00856	3.31e-299	mepA	-	-	V	ko:K18908	-	ko00000,ko00002,ko01504,ko02000	MATE efflux family protein
HIFLEHPO_00857	2.23e-314	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
HIFLEHPO_00858	5.28e-251	-	-	-	-	-	-	-	-
HIFLEHPO_00859	8.78e-157	XK27_10290	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HIFLEHPO_00860	1.35e-71	ytpP	-	-	CO	-	-	-	Thioredoxin
HIFLEHPO_00862	2.16e-163	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HIFLEHPO_00863	5.7e-282	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HIFLEHPO_00864	1.05e-173	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_00865	1.61e-101	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	Scavenger mRNA decapping enzyme C-term binding
HIFLEHPO_00866	1.2e-41	-	-	-	-	-	-	-	-
HIFLEHPO_00867	1.09e-196	prsA	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HIFLEHPO_00868	5.74e-96	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HIFLEHPO_00869	0.0	-	-	-	-	-	-	-	-
HIFLEHPO_00870	9.67e-33	-	-	-	S	-	-	-	Domain of unknown function DUF1829
HIFLEHPO_00872	4.53e-239	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIFLEHPO_00873	0.0	yhaN	-	-	L	-	-	-	AAA domain
HIFLEHPO_00874	1.88e-292	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	Ser Thr phosphatase family protein
HIFLEHPO_00875	8.43e-73	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
HIFLEHPO_00876	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HIFLEHPO_00877	2.09e-208	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HIFLEHPO_00878	0.0	pps	2.7.9.2	-	H	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
HIFLEHPO_00879	1.49e-13	-	-	-	G	-	-	-	Phosphoglycerate mutase family
HIFLEHPO_00880	1.91e-102	-	-	-	G	-	-	-	Phosphoglycerate mutase family
HIFLEHPO_00881	1.44e-234	-	-	-	L	-	-	-	Phage integrase family
HIFLEHPO_00882	3.94e-85	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
HIFLEHPO_00883	3.22e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HIFLEHPO_00884	1.06e-185	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HIFLEHPO_00885	5.12e-174	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIFLEHPO_00886	5.5e-202	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIFLEHPO_00887	1.02e-198	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HIFLEHPO_00888	2.23e-80	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
HIFLEHPO_00889	3.62e-218	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIFLEHPO_00890	3.82e-82	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HIFLEHPO_00891	3.44e-72	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIFLEHPO_00892	1.89e-21	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
HIFLEHPO_00893	3.13e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HIFLEHPO_00894	3.7e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HIFLEHPO_00895	1.25e-301	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HIFLEHPO_00896	4.95e-93	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HIFLEHPO_00897	2.22e-34	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
HIFLEHPO_00898	3.73e-110	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HIFLEHPO_00899	2.8e-72	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HIFLEHPO_00900	7.18e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HIFLEHPO_00901	7.94e-90	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HIFLEHPO_00902	1e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIFLEHPO_00903	1.23e-123	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIFLEHPO_00904	3.03e-44	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HIFLEHPO_00905	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HIFLEHPO_00906	1.56e-55	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HIFLEHPO_00907	1.45e-34	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
HIFLEHPO_00908	1.66e-100	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HIFLEHPO_00909	8.7e-157	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HIFLEHPO_00910	9.07e-73	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HIFLEHPO_00911	1.14e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HIFLEHPO_00912	4.01e-198	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HIFLEHPO_00913	1.14e-63	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HIFLEHPO_00914	4.68e-138	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
HIFLEHPO_00915	6.64e-146	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HIFLEHPO_00916	6.34e-66	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
HIFLEHPO_00917	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HIFLEHPO_00918	8.05e-106	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HIFLEHPO_00919	1.47e-91	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HIFLEHPO_00920	7.71e-157	comC	3.4.23.43	-	NOU	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	Bacterial Peptidase A24 N-terminal domain
HIFLEHPO_00921	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIFLEHPO_00922	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIFLEHPO_00923	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HIFLEHPO_00924	1.92e-106	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
HIFLEHPO_00929	3.35e-101	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
HIFLEHPO_00930	3.09e-71	-	-	-	-	-	-	-	-
HIFLEHPO_00931	2.96e-23	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HIFLEHPO_00932	8.56e-181	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
HIFLEHPO_00934	7.95e-06	-	-	-	-	-	-	-	-
HIFLEHPO_00935	2.84e-150	-	-	-	K	-	-	-	sequence-specific DNA binding
HIFLEHPO_00937	2.43e-145	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HIFLEHPO_00938	2.91e-186	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HIFLEHPO_00939	5.62e-95	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
HIFLEHPO_00940	2.34e-76	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HIFLEHPO_00941	2.19e-71	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HIFLEHPO_00942	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HIFLEHPO_00943	1.18e-66	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
HIFLEHPO_00944	9.37e-96	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIFLEHPO_00945	5.32e-57	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
HIFLEHPO_00946	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HIFLEHPO_00947	1.32e-305	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HIFLEHPO_00948	7.44e-230	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HIFLEHPO_00949	6.15e-268	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIFLEHPO_00950	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HIFLEHPO_00951	7.58e-69	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HIFLEHPO_00952	1.39e-237	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HIFLEHPO_00953	3.89e-132	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HIFLEHPO_00954	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HIFLEHPO_00955	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HIFLEHPO_00956	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HIFLEHPO_00957	1.06e-58	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HIFLEHPO_00958	2.79e-102	-	-	-	-	-	-	-	-
HIFLEHPO_00959	2.14e-231	-	-	-	M	-	-	-	CHAP domain
HIFLEHPO_00960	0.0	scrA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIFLEHPO_00961	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
HIFLEHPO_00962	2.14e-234	scrR	-	-	K	ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
HIFLEHPO_00963	3.6e-106	-	-	-	C	-	-	-	Flavodoxin
HIFLEHPO_00964	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HIFLEHPO_00965	5.81e-310	ynbB	-	-	P	-	-	-	aluminum resistance
HIFLEHPO_00966	0.0	speA	4.1.1.17, 4.1.1.18, 4.1.1.19	-	E	ko:K01581,ko:K01582,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Orn/Lys/Arg decarboxylase, C-terminal domain
HIFLEHPO_00967	0.0	-	-	-	E	-	-	-	Amino acid permease
HIFLEHPO_00968	9.58e-122	-	-	-	C	-	-	-	Pyridoxamine 5'-phosphate oxidase
HIFLEHPO_00969	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
HIFLEHPO_00970	2.47e-144	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HIFLEHPO_00971	1.31e-16	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine S-methyltransferase
HIFLEHPO_00972	2.95e-84	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HIFLEHPO_00973	9.28e-89	crcB1	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HIFLEHPO_00974	3.71e-195	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
HIFLEHPO_00975	8.85e-121	-	-	-	M	-	-	-	LysM domain protein
HIFLEHPO_00976	6.42e-110	-	-	-	C	-	-	-	Aldo keto reductase
HIFLEHPO_00977	9.4e-232	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
HIFLEHPO_00978	1.4e-313	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HIFLEHPO_00979	4.67e-116	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HIFLEHPO_00980	5.99e-180	xerC	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
HIFLEHPO_00981	8.35e-315	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HIFLEHPO_00982	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIFLEHPO_00983	1.5e-195	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
HIFLEHPO_00984	1e-168	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIFLEHPO_00985	2.15e-198	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HIFLEHPO_00986	2.4e-118	nhaP4	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HIFLEHPO_00987	7.2e-49	nhaP4	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HIFLEHPO_00988	3.67e-88	-	-	-	P	-	-	-	NhaP-type Na H and K H
HIFLEHPO_00989	9.85e-49	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
HIFLEHPO_00990	8.83e-187	degV3	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HIFLEHPO_00991	1.8e-143	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
HIFLEHPO_00992	5.13e-287	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HIFLEHPO_00993	1.15e-205	XK27_10395	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HIFLEHPO_00994	9.58e-112	-	3.4.21.96	-	S	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	SLAP domain
HIFLEHPO_00995	1.01e-240	yagE	-	-	E	-	-	-	Amino acid permease
HIFLEHPO_00996	9.62e-247	ldhA	1.1.1.28	-	C	ko:K03778,ko:K18347	ko00620,ko01120,ko01502,ko02020,map00620,map01120,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01504	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIFLEHPO_00997	1.07e-179	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIFLEHPO_00998	3.16e-192	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	haloacid dehalogenase-like hydrolase
HIFLEHPO_00999	0.0	fusA1	-	-	J	-	-	-	elongation factor G
HIFLEHPO_01000	9.52e-205	yvgN	-	-	C	-	-	-	Aldo keto reductase
HIFLEHPO_01001	7.2e-202	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HIFLEHPO_01002	7.75e-170	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HIFLEHPO_01003	9.61e-223	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
HIFLEHPO_01004	4.76e-168	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIFLEHPO_01005	8.64e-176	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01006	1.59e-315	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
HIFLEHPO_01007	2.55e-26	-	-	-	-	-	-	-	-
HIFLEHPO_01008	3.93e-134	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HIFLEHPO_01009	4.4e-226	ydbI	-	-	K	-	-	-	AI-2E family transporter
HIFLEHPO_01010	5.18e-135	oppA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_01011	3.62e-264	oppA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_01012	3.82e-149	tnpA1	-	-	L	-	-	-	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
HIFLEHPO_01013	0.0	-	-	-	M	-	-	-	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HIFLEHPO_01014	4.13e-38	-	-	-	M	-	-	-	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HIFLEHPO_01015	2.23e-189	-	-	-	S	-	-	-	Putative ABC-transporter type IV
HIFLEHPO_01017	4.11e-124	potE	-	-	E	-	-	-	thought to be involved in transport amino acids across the membrane
HIFLEHPO_01019	2.67e-35	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01020	6.66e-27	-	-	-	S	-	-	-	CAAX protease self-immunity
HIFLEHPO_01022	2.08e-33	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_01023	1.02e-74	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HIFLEHPO_01025	5.16e-135	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIFLEHPO_01026	1.43e-220	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HIFLEHPO_01027	1.13e-126	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HIFLEHPO_01028	2.34e-97	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HIFLEHPO_01029	7.09e-184	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_01030	6.89e-136	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter
HIFLEHPO_01031	3e-139	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01032	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HIFLEHPO_01033	1.02e-148	XK27_08875	-	-	O	-	-	-	PFAM peptidase M10A and M12B, matrixin and adamalysin
HIFLEHPO_01034	7.53e-163	gpm2	-	-	G	-	-	-	Phosphoglycerate mutase family
HIFLEHPO_01035	1.87e-308	-	-	-	S	-	-	-	response to antibiotic
HIFLEHPO_01036	2.7e-162	-	-	-	-	-	-	-	-
HIFLEHPO_01037	0.0	pacL3	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HIFLEHPO_01038	7.34e-86	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIFLEHPO_01039	1.42e-57	-	-	-	-	-	-	-	-
HIFLEHPO_01040	4.65e-14	-	-	-	-	-	-	-	-
HIFLEHPO_01041	4.71e-239	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase, type I
HIFLEHPO_01042	8.28e-176	-	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
HIFLEHPO_01043	0.0	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase C-terminal domain
HIFLEHPO_01044	8.75e-197	-	-	-	-	-	-	-	-
HIFLEHPO_01045	6.16e-14	-	-	-	-	-	-	-	-
HIFLEHPO_01046	5.45e-121	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HIFLEHPO_01047	2.77e-135	-	-	-	K	ko:K06977	-	ko00000	acetyltransferase
HIFLEHPO_01049	2.53e-287	lacE	2.7.1.207	-	G	ko:K02761,ko:K02787,ko:K02788	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01050	1.52e-105	-	-	-	L	-	-	-	MgsA AAA+ ATPase C terminal
HIFLEHPO_01051	5.62e-134	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIFLEHPO_01053	3.28e-133	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_01054	5.19e-248	-	-	-	G	-	-	-	Transmembrane secretion effector
HIFLEHPO_01055	1.49e-151	-	-	-	V	-	-	-	Abi-like protein
HIFLEHPO_01056	1.34e-175	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01057	1.3e-31	-	-	-	-	-	-	-	-
HIFLEHPO_01058	2.61e-195	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HIFLEHPO_01059	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIFLEHPO_01060	3.56e-186	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HIFLEHPO_01061	6.1e-228	yvdE	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
HIFLEHPO_01062	3.15e-259	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIFLEHPO_01063	3.2e-28	XK27_04775	-	-	S	ko:K09155	-	ko00000	PAS domain
HIFLEHPO_01064	1.42e-42	XK27_04775	-	-	S	ko:K09155	-	ko00000	PAS domain
HIFLEHPO_01065	0.0	malA1	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
HIFLEHPO_01066	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HIFLEHPO_01067	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
HIFLEHPO_01068	9.37e-150	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	beta-phosphoglucomutase
HIFLEHPO_01069	7e-267	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_01070	5.5e-282	-	-	-	G	ko:K15770	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_01071	0.0	malF	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_01072	1.39e-197	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01073	1.45e-74	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01074	3.16e-160	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
HIFLEHPO_01075	8.43e-206	-	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
HIFLEHPO_01076	2.42e-33	-	-	-	-	-	-	-	-
HIFLEHPO_01077	3.43e-164	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIFLEHPO_01078	1.99e-235	-	-	-	S	-	-	-	AAA domain
HIFLEHPO_01079	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
HIFLEHPO_01080	2.23e-69	-	-	-	-	-	-	-	-
HIFLEHPO_01081	5.22e-131	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTP diphosphatase
HIFLEHPO_01082	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HIFLEHPO_01083	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIFLEHPO_01084	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HIFLEHPO_01085	4.95e-98	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HIFLEHPO_01086	1.56e-177	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIFLEHPO_01087	3.81e-123	comX	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
HIFLEHPO_01088	1.19e-45	-	-	-	-	-	-	-	-
HIFLEHPO_01089	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HIFLEHPO_01090	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HIFLEHPO_01091	3.73e-33	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HIFLEHPO_01092	1.23e-130	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
HIFLEHPO_01093	3.82e-90	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HIFLEHPO_01094	1.05e-160	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HIFLEHPO_01095	5.48e-201	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HIFLEHPO_01096	2.29e-210	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HIFLEHPO_01097	3.01e-197	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HIFLEHPO_01098	5.24e-187	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIFLEHPO_01099	3.83e-178	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIFLEHPO_01100	2.89e-151	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HIFLEHPO_01101	9.7e-127	-	-	-	E	ko:K02054	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_01102	6.18e-123	rihC	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
HIFLEHPO_01103	1.07e-93	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HIFLEHPO_01104	9.64e-38	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
HIFLEHPO_01105	8.69e-76	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HIFLEHPO_01106	5.28e-193	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HIFLEHPO_01107	3.01e-255	tnpB	-	-	L	ko:K07496	-	ko00000	Putative transposase DNA-binding domain
HIFLEHPO_01108	6.85e-109	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
HIFLEHPO_01109	5.03e-256	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
HIFLEHPO_01110	1.77e-157	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HIFLEHPO_01111	9.22e-141	yqeK	-	-	H	-	-	-	Hydrolase, HD family
HIFLEHPO_01112	5.95e-77	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HIFLEHPO_01113	8.01e-276	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
HIFLEHPO_01114	2.19e-125	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
HIFLEHPO_01115	3.52e-163	csrR	-	-	K	-	-	-	response regulator
HIFLEHPO_01116	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIFLEHPO_01117	2.19e-18	-	-	-	-	-	-	-	-
HIFLEHPO_01118	4.28e-125	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIFLEHPO_01119	4.76e-170	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01120	2.05e-107	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01121	1.13e-108	-	-	-	S	ko:K19055	-	ko00000,ko01000,ko03016	Aminoacyl-tRNA editing domain
HIFLEHPO_01122	2.43e-216	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIFLEHPO_01123	5.58e-59	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
HIFLEHPO_01124	1.37e-173	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIFLEHPO_01125	3.71e-76	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HIFLEHPO_01127	1.81e-139	glnP9	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	ABC transporter, permease protein
HIFLEHPO_01128	1.96e-148	glnP7	-	-	P	ko:K02029	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01129	7.91e-164	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01130	1.2e-202	cjaA	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_01131	2.9e-254	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HIFLEHPO_01132	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HIFLEHPO_01133	2.55e-94	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HIFLEHPO_01134	3.9e-213	ldh3	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	lactate/malate dehydrogenase, alpha/beta C-terminal domain
HIFLEHPO_01135	5.88e-181	metQ	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HIFLEHPO_01136	1.8e-34	-	-	-	-	-	-	-	-
HIFLEHPO_01137	0.0	sufI	-	-	Q	-	-	-	Multicopper oxidase
HIFLEHPO_01138	1.76e-193	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIFLEHPO_01139	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_01140	8.29e-294	-	-	-	Q	-	-	-	Imidazolonepropionase and related amidohydrolases
HIFLEHPO_01141	2.48e-313	-	-	-	S	ko:K12941	-	ko00000,ko01002	Peptidase dimerisation domain
HIFLEHPO_01142	3.2e-176	-	-	-	S	-	-	-	Protein of unknown function (DUF3100)
HIFLEHPO_01143	2.04e-60	-	-	-	S	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_01144	6.91e-67	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
HIFLEHPO_01145	3.7e-164	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01146	1.75e-120	-	-	-	-	-	-	-	-
HIFLEHPO_01148	4.07e-158	-	-	-	M	ko:K14193	ko05150,map05150	ko00000,ko00001	Iron Transport-associated domain
HIFLEHPO_01149	1.7e-202	isdE	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
HIFLEHPO_01150	2.2e-201	isdF	-	-	U	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIFLEHPO_01151	1.49e-178	-	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	abc transporter atp-binding protein
HIFLEHPO_01152	2.22e-60	hupB2	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HIFLEHPO_01153	2.74e-69	-	-	-	S	ko:K19157	-	ko00000,ko01000,ko02048	Bacterial toxin of type II toxin-antitoxin system, YafQ
HIFLEHPO_01154	9.43e-52	-	-	-	S	ko:K07473	-	ko00000,ko02048	RelB antitoxin
HIFLEHPO_01155	7.04e-218	-	-	-	G	-	-	-	BadF/BadG/BcrA/BcrD ATPase family
HIFLEHPO_01156	0.0	-	-	-	S	-	-	-	membrane
HIFLEHPO_01157	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HIFLEHPO_01158	6.25e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HIFLEHPO_01159	1.94e-126	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIFLEHPO_01160	9.32e-154	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Rhomboid family
HIFLEHPO_01161	1e-47	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
HIFLEHPO_01162	4.95e-89	yqhL	-	-	P	-	-	-	Rhodanese-like protein
HIFLEHPO_01163	1.9e-216	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HIFLEHPO_01164	1.74e-282	ynbB	-	-	P	-	-	-	aluminum resistance
HIFLEHPO_01165	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
HIFLEHPO_01166	9.64e-219	-	-	-	-	-	-	-	-
HIFLEHPO_01167	1.21e-204	-	-	-	-	-	-	-	-
HIFLEHPO_01171	6.78e-47	-	-	-	-	-	-	-	-
HIFLEHPO_01172	1.94e-165	-	-	-	S	-	-	-	interspecies interaction between organisms
HIFLEHPO_01173	1.28e-09	-	-	-	S	-	-	-	PFAM HicB family
HIFLEHPO_01174	2.86e-13	-	-	-	K	ko:K15773	-	ko00000,ko02048,ko03000	peptidyl-tyrosine sulfation
HIFLEHPO_01175	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_01176	1.57e-84	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIFLEHPO_01177	5.61e-156	nanA	4.1.3.3	-	EM	ko:K01639	ko00520,map00520	ko00000,ko00001,ko01000	Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate
HIFLEHPO_01178	1.03e-112	nanK	-	-	GK	-	-	-	ROK family
HIFLEHPO_01179	3.74e-70	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
HIFLEHPO_01180	6.95e-165	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HIFLEHPO_01181	6.48e-279	-	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIFLEHPO_01182	2.82e-84	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
HIFLEHPO_01183	1.48e-28	axe1	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	acetyl xylan esterase
HIFLEHPO_01184	1.19e-141	nanE	5.1.3.9	-	G	ko:K01788	ko00520,map00520	ko00000,ko00001,ko01000	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HIFLEHPO_01185	1.1e-155	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIFLEHPO_01186	3.07e-136	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HIFLEHPO_01187	7.93e-139	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HIFLEHPO_01188	3.68e-93	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Glycerol-3-phosphate cytidylyltransferase
HIFLEHPO_01189	1.87e-159	gntR1	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HIFLEHPO_01190	1.53e-232	-	-	-	-	-	-	-	-
HIFLEHPO_01191	0.0	oppA2	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_01194	7.62e-306	npr	1.11.1.1	-	C	ko:K05910	-	ko00000,ko01000	NADH oxidase
HIFLEHPO_01195	1.48e-14	-	-	-	-	-	-	-	-
HIFLEHPO_01196	5.24e-31	-	-	-	S	-	-	-	transposase or invertase
HIFLEHPO_01197	9.6e-309	slpX	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01198	1.43e-186	-	-	-	K	-	-	-	SIS domain
HIFLEHPO_01199	3.01e-154	rpiA1	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
HIFLEHPO_01200	1.03e-237	XK27_10475	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
HIFLEHPO_01201	1.93e-266	araT	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIFLEHPO_01203	0.0	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HIFLEHPO_01205	2.67e-148	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HIFLEHPO_01206	1.9e-153	-	-	-	G	-	-	-	Antibiotic biosynthesis monooxygenase
HIFLEHPO_01207	9.01e-115	-	-	-	G	-	-	-	Histidine phosphatase superfamily (branch 1)
HIFLEHPO_01208	8.92e-136	-	-	-	G	-	-	-	Phosphoglycerate mutase family
HIFLEHPO_01209	5.68e-211	-	-	-	D	-	-	-	nuclear chromosome segregation
HIFLEHPO_01210	1.33e-130	-	-	-	M	-	-	-	LysM domain protein
HIFLEHPO_01211	2.57e-108	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01212	8.08e-160	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01213	0.0	uvrA2	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC, A subunit
HIFLEHPO_01214	3.73e-240	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine S-methyltransferase
HIFLEHPO_01215	5.94e-148	-	-	-	I	-	-	-	Acid phosphatase homologues
HIFLEHPO_01216	1.12e-104	yvbK	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HIFLEHPO_01217	8.83e-147	maa3	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
HIFLEHPO_01218	1.59e-259	pbpX1	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_01219	3.1e-127	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Phosphomethylpyrimidine kinase
HIFLEHPO_01220	7.89e-124	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
HIFLEHPO_01221	4.6e-291	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HIFLEHPO_01222	1.41e-108	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIFLEHPO_01223	0.0	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HIFLEHPO_01224	1.13e-241	-	-	-	L	ko:K07478	-	ko00000	AAA C-terminal domain
HIFLEHPO_01225	2.76e-86	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HIFLEHPO_01226	0.0	treB	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HIFLEHPO_01227	2.09e-129	treR	-	-	K	ko:K03486	-	ko00000,ko03000	UTRA
HIFLEHPO_01228	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HIFLEHPO_01230	2.55e-177	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_01231	6.73e-107	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_01232	4.09e-80	-	-	-	S	ko:K07006	-	ko00000	Pyridoxamine 5'-phosphate oxidase
HIFLEHPO_01233	4e-300	XK27_01810	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIFLEHPO_01239	5.95e-114	ymdB	-	-	S	-	-	-	Macro domain protein
HIFLEHPO_01240	7e-242	mdtG2	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
HIFLEHPO_01241	7.62e-223	-	-	-	-	-	-	-	-
HIFLEHPO_01242	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIFLEHPO_01243	6.08e-153	phoB	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
HIFLEHPO_01244	3.12e-135	-	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HIFLEHPO_01245	1.68e-177	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HIFLEHPO_01246	4.1e-193	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HIFLEHPO_01247	5.64e-201	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HIFLEHPO_01248	2.34e-187	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HIFLEHPO_01249	5.68e-34	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
HIFLEHPO_01250	7.06e-102	yveB	-	-	I	-	-	-	PAP2 superfamily
HIFLEHPO_01251	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
HIFLEHPO_01252	2.2e-79	lysM	-	-	M	-	-	-	LysM domain
HIFLEHPO_01253	0.0	-	-	-	L	-	-	-	Transposase
HIFLEHPO_01254	4.92e-43	-	-	-	L	-	-	-	Transposase DDE domain
HIFLEHPO_01255	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
HIFLEHPO_01256	7.74e-61	-	-	-	-	-	-	-	-
HIFLEHPO_01257	1.04e-48	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HIFLEHPO_01258	1.15e-155	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HIFLEHPO_01259	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HIFLEHPO_01260	7.99e-185	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
HIFLEHPO_01261	1.74e-111	-	-	-	-	-	-	-	-
HIFLEHPO_01262	7.76e-98	-	-	-	-	-	-	-	-
HIFLEHPO_01263	1.45e-180	hlyX	-	-	S	ko:K03699	-	ko00000,ko02042	Transporter associated domain
HIFLEHPO_01264	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HIFLEHPO_01265	8.42e-60	XK27_09445	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HIFLEHPO_01266	0.0	clpE	-	-	O	ko:K03697	-	ko00000,ko03110	Belongs to the ClpA ClpB family
HIFLEHPO_01267	2.6e-37	-	-	-	-	-	-	-	-
HIFLEHPO_01268	1.29e-54	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
HIFLEHPO_01269	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIFLEHPO_01270	4.25e-85	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HIFLEHPO_01271	1.5e-178	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HIFLEHPO_01272	6.73e-208	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
HIFLEHPO_01273	5.74e-148	yjbH	-	-	Q	-	-	-	Thioredoxin
HIFLEHPO_01274	1.71e-143	-	-	-	S	-	-	-	CYTH
HIFLEHPO_01275	1.7e-147	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
HIFLEHPO_01276	1.91e-195	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HIFLEHPO_01277	9.29e-220	rluD2	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HIFLEHPO_01278	0.0	mycA	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
HIFLEHPO_01279	3.77e-122	-	-	-	S	-	-	-	SNARE associated Golgi protein
HIFLEHPO_01280	7.21e-140	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01281	6.39e-21	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01282	7.26e-136	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01283	7.36e-291	-	-	-	S	-	-	-	Cysteine-rich secretory protein family
HIFLEHPO_01284	2.43e-263	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
HIFLEHPO_01285	3.47e-164	-	-	-	-	-	-	-	-
HIFLEHPO_01286	1.69e-258	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
HIFLEHPO_01287	7.8e-167	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
HIFLEHPO_01288	1.2e-202	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HIFLEHPO_01289	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
HIFLEHPO_01290	1.03e-275	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIFLEHPO_01291	3.47e-19	-	-	-	-	ko:K07473	-	ko00000,ko02048	-
HIFLEHPO_01293	4.83e-117	ntd	2.4.2.6	-	F	ko:K08728	ko00240,map00240	ko00000,ko00001,ko01000	Nucleoside
HIFLEHPO_01294	6.51e-114	-	2.7.1.200, 2.7.1.204	-	G	ko:K02773,ko:K20112	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_01295	1.02e-190	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HIFLEHPO_01296	3.92e-110	usp5	-	-	T	-	-	-	universal stress protein
HIFLEHPO_01298	1.57e-208	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter
HIFLEHPO_01299	6.34e-180	phnC	3.6.3.28	-	P	ko:K02041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HIFLEHPO_01300	4.7e-169	phnB	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_01301	1.29e-190	-	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_01302	1.21e-40	-	-	-	-	-	-	-	-
HIFLEHPO_01303	1.05e-54	-	-	-	S	-	-	-	Protein of unknown function (DUF2922)
HIFLEHPO_01304	6.77e-139	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01305	6.35e-28	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_01306	4.56e-191	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_01308	2.45e-65	-	-	-	K	-	-	-	DNA-templated transcription, initiation
HIFLEHPO_01309	2.85e-54	-	-	-	-	-	-	-	-
HIFLEHPO_01311	7.39e-165	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01313	2.09e-286	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HIFLEHPO_01314	7.32e-232	-	3.2.1.96, 3.5.1.28	GH73	M	ko:K01227,ko:K01447,ko:K13714,ko:K13731	ko00511,ko05100,map00511,map05100	ko00000,ko00001,ko01000	N-acetylmuramoyl-L-alanine amidase
HIFLEHPO_01315	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
HIFLEHPO_01316	2.47e-138	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HIFLEHPO_01317	1.68e-207	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
HIFLEHPO_01318	1.98e-168	-	-	-	-	-	-	-	-
HIFLEHPO_01319	1.72e-149	-	-	-	-	-	-	-	-
HIFLEHPO_01320	4.51e-171	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIFLEHPO_01321	3.61e-60	-	-	-	-	-	-	-	-
HIFLEHPO_01322	4.53e-76	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
HIFLEHPO_01324	3.75e-48	-	-	-	S	-	-	-	PFAM Archaeal ATPase
HIFLEHPO_01325	6.55e-97	-	-	-	-	-	-	-	-
HIFLEHPO_01326	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
HIFLEHPO_01327	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HIFLEHPO_01328	2.31e-277	yqjV	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIFLEHPO_01329	2.19e-292	XK27_04775	-	-	S	ko:K09155	-	ko00000	PAS domain
HIFLEHPO_01330	3.41e-132	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HIFLEHPO_01331	1.35e-180	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIFLEHPO_01332	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
HIFLEHPO_01333	0.0	yxbA	6.3.1.12	-	S	ko:K17810	-	ko00000,ko01000	ATP-grasp enzyme
HIFLEHPO_01334	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HIFLEHPO_01335	0.0	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HIFLEHPO_01336	2.47e-107	-	-	-	-	-	-	-	-
HIFLEHPO_01337	5.61e-138	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HIFLEHPO_01338	2.82e-17	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
HIFLEHPO_01339	2.73e-21	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
HIFLEHPO_01340	6.8e-48	-	-	-	S	ko:K19157	-	ko00000,ko01000,ko02048	Bacterial toxin of type II toxin-antitoxin system, YafQ
HIFLEHPO_01341	4.82e-102	-	-	-	V	-	-	-	Type I restriction modification DNA specificity domain
HIFLEHPO_01342	5.44e-299	-	-	-	V	-	-	-	N-6 DNA Methylase
HIFLEHPO_01343	9.56e-129	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_01344	1.71e-156	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HIFLEHPO_01345	7.98e-35	-	-	-	GKT	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_01346	4.68e-25	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIFLEHPO_01347	8.24e-257	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIFLEHPO_01348	7.62e-32	-	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_01350	1.78e-21	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_01351	5.85e-67	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_01353	1.54e-87	doc	-	-	S	ko:K07341	-	ko00000,ko02048	Fic/DOC family
HIFLEHPO_01354	2.78e-45	-	-	-	-	-	-	-	-
HIFLEHPO_01355	1.51e-27	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIFLEHPO_01357	2.72e-158	-	-	-	L	-	-	-	This gene contains a nucleotide ambiguity which may be the result of a sequencing error
HIFLEHPO_01359	1.64e-19	-	-	-	-	-	-	-	-
HIFLEHPO_01360	0.0	-	-	-	C	-	-	-	FMN_bind
HIFLEHPO_01361	3.53e-287	-	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
HIFLEHPO_01362	2.52e-140	-	-	-	K	-	-	-	LysR family
HIFLEHPO_01363	0.0	-	-	-	C	-	-	-	FMN_bind
HIFLEHPO_01364	4.07e-140	-	-	-	K	-	-	-	LysR family
HIFLEHPO_01365	1.18e-89	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_01366	2.28e-21	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_01367	1.22e-157	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HIFLEHPO_01368	4.92e-73	dhaM	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
HIFLEHPO_01369	1.39e-120	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
HIFLEHPO_01370	2.55e-223	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
HIFLEHPO_01371	0.0	prtB	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HIFLEHPO_01372	2.43e-93	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HIFLEHPO_01374	2.94e-74	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
HIFLEHPO_01375	2.23e-150	yviA	-	-	S	-	-	-	Protein of unknown function (DUF421)
HIFLEHPO_01376	5.96e-202	-	-	-	K	-	-	-	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HIFLEHPO_01377	2.22e-231	-	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	EXOIII
HIFLEHPO_01378	7.24e-204	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
HIFLEHPO_01379	0.0	pepD1	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIFLEHPO_01380	3.7e-259	malK	-	-	P	ko:K10112,ko:K17240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
HIFLEHPO_01381	3.85e-201	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	ABC-type sugar transport systems, permease components
HIFLEHPO_01382	5.62e-187	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HIFLEHPO_01383	0.0	-	-	-	S	-	-	-	Zn-dependent metallo-hydrolase RNA specificity domain
HIFLEHPO_01384	6.07e-310	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_01385	1.4e-207	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HIFLEHPO_01386	2.68e-205	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
HIFLEHPO_01387	3.76e-128	yobS	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIFLEHPO_01388	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	MMPL family
HIFLEHPO_01389	2.06e-92	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
HIFLEHPO_01390	8.21e-57	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HIFLEHPO_01391	1.34e-314	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
HIFLEHPO_01392	1.4e-281	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
HIFLEHPO_01393	1.96e-148	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
HIFLEHPO_01394	1.13e-41	-	-	-	M	-	-	-	Lysin motif
HIFLEHPO_01395	8.49e-146	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HIFLEHPO_01396	4.65e-168	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HIFLEHPO_01397	7.57e-135	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIFLEHPO_01398	1.81e-169	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIFLEHPO_01399	7.97e-82	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HIFLEHPO_01400	6.74e-213	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
HIFLEHPO_01401	1.21e-213	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
HIFLEHPO_01402	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
HIFLEHPO_01403	5.46e-233	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HIFLEHPO_01404	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
HIFLEHPO_01405	1.25e-38	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
HIFLEHPO_01406	0.0	yfkN	3.1.3.6, 3.1.4.16	-	F	ko:K01119	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HIFLEHPO_01407	4.97e-102	-	-	-	S	-	-	-	N-acetylmuramoyl-L-alanine amidase activity
HIFLEHPO_01408	5.77e-39	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
HIFLEHPO_01417	7.82e-158	-	-	-	S	-	-	-	Phage minor structural protein
HIFLEHPO_01419	2.31e-134	-	-	-	L	-	-	-	Phage tail tape measure protein TP901
HIFLEHPO_01427	8.25e-69	-	-	-	S	-	-	-	Phage capsid family
HIFLEHPO_01428	1.59e-110	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S14 family
HIFLEHPO_01429	4.25e-167	-	-	-	S	-	-	-	Phage portal protein
HIFLEHPO_01431	2.37e-263	-	-	-	S	-	-	-	Phage Terminase
HIFLEHPO_01433	1.71e-72	-	-	-	S	-	-	-	Phage terminase, small subunit
HIFLEHPO_01437	3.85e-49	-	-	-	S	-	-	-	VRR_NUC
HIFLEHPO_01448	0.0	-	-	-	S	ko:K06919	-	ko00000	Phage plasmid primase, P4
HIFLEHPO_01449	1e-23	-	-	-	S	-	-	-	Protein of unknown function (DUF669)
HIFLEHPO_01450	4.6e-184	-	-	-	L	-	-	-	Helicase C-terminal domain protein
HIFLEHPO_01452	9.54e-88	-	-	-	S	-	-	-	AAA domain
HIFLEHPO_01453	8.93e-33	-	-	-	S	-	-	-	HNH endonuclease
HIFLEHPO_01460	2.87e-93	-	-	-	K	ko:K07741	-	ko00000	AntA/AntB antirepressor
HIFLEHPO_01461	1.7e-23	-	-	-	-	-	-	-	-
HIFLEHPO_01464	1.8e-20	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01466	2.99e-31	-	-	-	S	-	-	-	Hypothetical protein (DUF2513)
HIFLEHPO_01469	1.56e-166	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_01470	5.14e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
HIFLEHPO_01471	3.57e-47	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
HIFLEHPO_01472	3.65e-180	-	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
HIFLEHPO_01473	6.82e-223	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HIFLEHPO_01474	0.0	oatA	-	-	I	-	-	-	Acyltransferase
HIFLEHPO_01475	1.88e-309	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIFLEHPO_01476	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HIFLEHPO_01477	1.58e-140	yngC	-	-	S	-	-	-	SNARE associated Golgi protein
HIFLEHPO_01478	0.0	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
HIFLEHPO_01479	6.61e-230	gyaR	1.1.1.26, 1.1.1.399, 1.1.1.95	-	CH	ko:K00015,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIFLEHPO_01480	1.72e-126	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
HIFLEHPO_01481	2.46e-128	-	-	-	L	-	-	-	PFAM Integrase catalytic
HIFLEHPO_01482	6.08e-148	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HIFLEHPO_01483	6.55e-76	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HIFLEHPO_01484	1.45e-34	-	-	-	K	-	-	-	FCD
HIFLEHPO_01485	1.43e-19	-	-	-	K	-	-	-	FCD
HIFLEHPO_01486	4.37e-132	-	-	-	GM	-	-	-	NmrA-like family
HIFLEHPO_01487	5.5e-154	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HIFLEHPO_01488	6.35e-164	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HIFLEHPO_01489	1.52e-212	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HIFLEHPO_01490	1.01e-122	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HIFLEHPO_01491	9.05e-231	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
HIFLEHPO_01492	2.04e-313	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HIFLEHPO_01493	3.47e-268	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HIFLEHPO_01494	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HIFLEHPO_01495	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
HIFLEHPO_01496	1.64e-99	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HIFLEHPO_01497	1.1e-152	-	3.8.1.2	-	S	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HIFLEHPO_01498	4.57e-135	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
HIFLEHPO_01499	6.11e-66	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
HIFLEHPO_01500	4.4e-86	-	-	-	K	-	-	-	LytTr DNA-binding domain
HIFLEHPO_01502	1.21e-72	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HIFLEHPO_01503	7.51e-16	-	-	-	L	-	-	-	Transposase
HIFLEHPO_01504	1.01e-22	-	-	-	L	-	-	-	Transposase
HIFLEHPO_01505	9.78e-216	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HIFLEHPO_01506	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HIFLEHPO_01507	5.85e-86	nt5e	3.1.3.18	-	L	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	haloacid dehalogenase-like hydrolase
HIFLEHPO_01508	1.52e-157	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HIFLEHPO_01509	1.78e-163	sga	5.1.3.22	-	G	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Xylose isomerase-like TIM barrel
HIFLEHPO_01510	2.85e-115	ulaD	4.1.1.85, 4.1.2.43	-	G	ko:K03078,ko:K08093	ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
HIFLEHPO_01511	4.82e-42	ulaB	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIFLEHPO_01512	2.8e-294	sgaT	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HIFLEHPO_01513	4.93e-80	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_01514	6.33e-221	ulaG	-	-	S	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Beta-lactamase superfamily domain
HIFLEHPO_01515	8.28e-102	-	-	-	S	-	-	-	helix_turn_helix, Deoxyribose operon repressor
HIFLEHPO_01516	6.72e-177	-	-	-	EP	-	-	-	Plasmid replication protein
HIFLEHPO_01517	4.63e-32	-	-	-	-	-	-	-	-
HIFLEHPO_01518	6.89e-190	glvR	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
HIFLEHPO_01519	1.52e-103	-	-	-	-	-	-	-	-
HIFLEHPO_01520	1.96e-113	ptbA	2.7.1.208	-	G	ko:K02755,ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HIFLEHPO_01521	1.76e-52	-	-	-	-	-	-	-	-
HIFLEHPO_01522	2.14e-154	-	-	-	C	-	-	-	nitroreductase
HIFLEHPO_01523	0.0	yhdP	-	-	S	-	-	-	Transporter associated domain
HIFLEHPO_01524	8.59e-133	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HIFLEHPO_01525	0.0	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
HIFLEHPO_01526	3.36e-112	-	-	-	L	-	-	-	PFAM transposase, IS4 family protein
HIFLEHPO_01527	5.83e-67	-	-	-	L	-	-	-	PFAM transposase, IS4 family protein
HIFLEHPO_01528	0.0	-	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
HIFLEHPO_01529	1.29e-295	-	-	-	E	ko:K03294	-	ko00000	amino acid
HIFLEHPO_01530	2.13e-167	lys	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HIFLEHPO_01531	5.96e-283	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
HIFLEHPO_01532	1.97e-315	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01534	4.65e-278	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HIFLEHPO_01535	3.61e-85	-	-	-	L	-	-	-	DDE superfamily endonuclease
HIFLEHPO_01536	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
HIFLEHPO_01537	8.61e-54	-	-	-	S	-	-	-	Enterocin A Immunity
HIFLEHPO_01538	1.71e-172	-	-	-	S	ko:K07052	-	ko00000	CAAX amino terminal protease
HIFLEHPO_01542	6.21e-60	-	-	-	V	ko:K20345	ko02024,map02024	ko00000,ko00001,ko02000	HlyD family secretion protein
HIFLEHPO_01543	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HIFLEHPO_01544	1.64e-101	-	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HIFLEHPO_01545	1.72e-97	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
HIFLEHPO_01548	2.02e-35	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01549	9.66e-12	-	-	-	-	-	-	-	-
HIFLEHPO_01550	2.29e-274	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
HIFLEHPO_01551	3.98e-116	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HIFLEHPO_01553	2.34e-107	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
HIFLEHPO_01554	9.98e-91	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
HIFLEHPO_01555	2.29e-112	-	-	-	-	-	-	-	-
HIFLEHPO_01556	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIFLEHPO_01557	6.14e-233	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HIFLEHPO_01558	2.94e-189	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIFLEHPO_01559	7.53e-186	-	-	-	S	-	-	-	Protein of unknown function (DUF1002)
HIFLEHPO_01560	2.62e-199	epsV	-	-	S	-	-	-	glycosyl transferase family 2
HIFLEHPO_01561	4.69e-158	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HIFLEHPO_01562	5.02e-190	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_01564	2.7e-79	-	-	-	-	-	-	-	-
HIFLEHPO_01566	2.15e-253	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HIFLEHPO_01567	5.46e-181	noxC	1.5.1.39	-	C	ko:K19286	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	coenzyme F420-1:gamma-L-glutamate ligase activity
HIFLEHPO_01568	1.45e-232	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIFLEHPO_01569	8.37e-161	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIFLEHPO_01570	2.62e-176	-	-	-	-	-	-	-	-
HIFLEHPO_01571	4.34e-174	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01572	5.55e-80	-	-	-	L	ko:K07497	-	ko00000	COG2963 Transposase and inactivated derivatives
HIFLEHPO_01573	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
HIFLEHPO_01574	6.51e-247	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIFLEHPO_01575	3.91e-214	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HIFLEHPO_01576	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIFLEHPO_01577	3.35e-308	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HIFLEHPO_01578	1.61e-81	-	-	-	J	ko:K07571	-	ko00000	S1 RNA binding domain
HIFLEHPO_01579	7.52e-78	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
HIFLEHPO_01580	7.32e-46	yabO	-	-	J	-	-	-	S4 domain protein
HIFLEHPO_01581	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIFLEHPO_01582	1.89e-134	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HIFLEHPO_01583	2.93e-234	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HIFLEHPO_01584	1.23e-166	-	-	-	S	-	-	-	(CBS) domain
HIFLEHPO_01598	5.39e-106	-	-	-	L	ko:K02315	-	ko00000,ko03032	IstB-like ATP binding protein
HIFLEHPO_01599	1.95e-71	-	-	-	S	-	-	-	calcium ion binding
HIFLEHPO_01600	3.84e-81	-	-	-	S	-	-	-	ERF superfamily
HIFLEHPO_01606	3.28e-144	-	-	-	K	ko:K07741	-	ko00000	BRO family, N-terminal domain
HIFLEHPO_01607	8.39e-07	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01608	5.63e-57	-	-	-	K	-	-	-	Peptidase S24-like
HIFLEHPO_01611	2.14e-45	-	-	-	V	-	-	-	Abi-like protein
HIFLEHPO_01612	6.35e-90	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_01629	8.71e-92	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
HIFLEHPO_01630	7.1e-106	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HIFLEHPO_01631	3.17e-224	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
HIFLEHPO_01632	1.19e-188	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
HIFLEHPO_01633	7.44e-192	yycI	-	-	S	-	-	-	YycH protein
HIFLEHPO_01634	0.0	yycH	-	-	S	-	-	-	YycH protein
HIFLEHPO_01635	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HIFLEHPO_01636	3.98e-169	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HIFLEHPO_01638	1.09e-46	-	-	-	-	-	-	-	-
HIFLEHPO_01640	4.19e-192	-	-	-	I	-	-	-	Acyl-transferase
HIFLEHPO_01641	7.23e-201	arbx	-	-	M	-	-	-	Glycosyl transferase family 8
HIFLEHPO_01642	1.91e-236	-	-	-	M	-	-	-	Glycosyl transferase family 8
HIFLEHPO_01643	5.48e-235	-	-	-	M	-	-	-	Glycosyl transferase family 8
HIFLEHPO_01644	3.92e-215	arbZ	-	-	I	-	-	-	Phosphate acyltransferases
HIFLEHPO_01645	6.8e-50	-	-	-	S	-	-	-	Cytochrome B5
HIFLEHPO_01646	3.64e-46	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
HIFLEHPO_01647	7.11e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HIFLEHPO_01648	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HIFLEHPO_01649	9e-190	-	-	-	-	-	-	-	-
HIFLEHPO_01650	5.76e-287	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HIFLEHPO_01651	1.09e-292	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HIFLEHPO_01652	3.04e-297	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HIFLEHPO_01653	1.59e-136	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
HIFLEHPO_01654	2.58e-48	potE	-	-	E	-	-	-	Amino Acid
HIFLEHPO_01655	1.27e-220	potE	-	-	E	-	-	-	Amino Acid
HIFLEHPO_01656	6.25e-246	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HIFLEHPO_01657	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HIFLEHPO_01658	1.39e-312	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HIFLEHPO_01659	5.02e-189	peb1A	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_01660	2.62e-166	-	-	-	F	-	-	-	glutamine amidotransferase
HIFLEHPO_01661	9.76e-312	steT	-	-	E	ko:K03294	-	ko00000	amino acid
HIFLEHPO_01662	1.8e-305	steT	-	-	E	ko:K03294	-	ko00000	amino acid
HIFLEHPO_01663	6.41e-194	-	-	-	-	-	-	-	-
HIFLEHPO_01664	6.07e-223	ydhF	-	-	S	-	-	-	Aldo keto reductase
HIFLEHPO_01665	0.0	ykpA	-	-	S	-	-	-	ABC transporter, ATP-binding protein
HIFLEHPO_01666	4.37e-266	pepA	-	-	E	-	-	-	M42 glutamyl aminopeptidase
HIFLEHPO_01667	7.33e-59	-	-	-	-	-	-	-	-
HIFLEHPO_01668	5.43e-172	-	-	-	-	-	-	-	-
HIFLEHPO_01669	6.86e-276	pmrA	-	-	EGP	ko:K08161	-	ko00000,ko02000	MFS_1 like family
HIFLEHPO_01670	0.0	qacA	-	-	EGP	-	-	-	Major Facilitator
HIFLEHPO_01671	0.0	-	-	-	S	-	-	-	Fibronectin type III domain
HIFLEHPO_01672	7.03e-307	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIFLEHPO_01673	9.39e-71	-	-	-	-	-	-	-	-
HIFLEHPO_01675	0.0	pepC2	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
HIFLEHPO_01676	1.77e-157	ypgQ	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIFLEHPO_01677	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_01678	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_01679	0.0	-	-	-	L	-	-	-	Transposase DDE domain
HIFLEHPO_01680	2.64e-266	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HIFLEHPO_01681	5.46e-191	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIFLEHPO_01682	7.82e-240	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIFLEHPO_01683	7.1e-252	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_01684	1.8e-190	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_01685	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
HIFLEHPO_01686	8.35e-94	hsp	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HIFLEHPO_01687	5.69e-100	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HIFLEHPO_01688	1.67e-143	-	-	-	-	-	-	-	-
HIFLEHPO_01690	1.66e-143	-	-	-	E	-	-	-	Belongs to the SOS response-associated peptidase family
HIFLEHPO_01691	4.07e-245	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HIFLEHPO_01692	1.5e-116	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	MafB19-like deaminase
HIFLEHPO_01693	4.57e-135	-	-	-	S	ko:K06872	-	ko00000	TPM domain
HIFLEHPO_01694	4.37e-173	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HIFLEHPO_01695	0.0	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HIFLEHPO_01696	3.02e-49	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HIFLEHPO_01697	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIFLEHPO_01698	1.11e-188	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
HIFLEHPO_01699	5.17e-129	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HIFLEHPO_01700	1.57e-203	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HIFLEHPO_01701	1.42e-52	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
HIFLEHPO_01702	5.03e-191	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
HIFLEHPO_01703	5.17e-307	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HIFLEHPO_01704	5.52e-113	-	-	-	-	-	-	-	-
HIFLEHPO_01705	0.0	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01706	5.4e-226	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIFLEHPO_01707	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIFLEHPO_01708	2.3e-169	yecA	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HIFLEHPO_01709	8.39e-314	ptcC	-	-	U	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01710	7.03e-216	-	-	-	GK	-	-	-	ROK family
HIFLEHPO_01711	3.56e-56	-	-	-	-	-	-	-	-
HIFLEHPO_01712	0.0	-	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HIFLEHPO_01713	1.75e-89	-	-	-	S	-	-	-	Domain of unknown function (DUF1934)
HIFLEHPO_01714	2.38e-88	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HIFLEHPO_01715	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HIFLEHPO_01716	6.58e-311	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIFLEHPO_01717	4.61e-104	-	-	-	K	-	-	-	acetyltransferase
HIFLEHPO_01718	1.69e-61	-	-	-	F	-	-	-	AAA domain
HIFLEHPO_01719	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIFLEHPO_01720	6.38e-191	msmR	-	-	K	-	-	-	AraC-like ligand binding domain
HIFLEHPO_01721	8.34e-294	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
HIFLEHPO_01722	9.63e-136	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HIFLEHPO_01723	6.18e-54	-	-	-	K	-	-	-	Helix-turn-helix
HIFLEHPO_01724	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
HIFLEHPO_01726	1.89e-129	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
HIFLEHPO_01727	1.91e-24	-	-	-	D	-	-	-	GA module
HIFLEHPO_01728	1.62e-276	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIFLEHPO_01729	9.39e-80	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HIFLEHPO_01730	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HIFLEHPO_01731	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HIFLEHPO_01732	1.07e-52	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
HIFLEHPO_01733	0.0	dexB	3.2.1.70	-	G	ko:K01215	-	ko00000,ko01000	Alpha amylase, catalytic domain protein
HIFLEHPO_01734	1.64e-200	yhaX	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HIFLEHPO_01735	0.0	-	-	-	E	-	-	-	amino acid
HIFLEHPO_01736	5.66e-297	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HIFLEHPO_01737	1.17e-56	-	-	-	-	-	-	-	-
HIFLEHPO_01738	8.68e-69	-	-	-	-	-	-	-	-
HIFLEHPO_01739	3.44e-238	-	-	-	C	-	-	-	FMN-dependent dehydrogenase
HIFLEHPO_01740	9.69e-184	-	-	-	P	-	-	-	Voltage gated chloride channel
HIFLEHPO_01741	8.74e-62	-	-	-	-	-	-	-	-
HIFLEHPO_01742	2.88e-105	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
HIFLEHPO_01743	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HIFLEHPO_01744	2.19e-49	-	-	-	S	-	-	-	Alpha beta hydrolase
HIFLEHPO_01745	2.1e-82	-	-	-	S	-	-	-	Alpha beta hydrolase
HIFLEHPO_01746	8.51e-50	-	-	-	-	-	-	-	-
HIFLEHPO_01747	4.3e-66	-	-	-	-	-	-	-	-
HIFLEHPO_01748	7.71e-188	supH	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HIFLEHPO_01749	0.0	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_01750	0.0	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_01751	1.82e-86	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
HIFLEHPO_01752	3.31e-185	lipA	-	-	I	-	-	-	Carboxylesterase family
HIFLEHPO_01754	1.16e-269	-	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HIFLEHPO_01755	2.65e-197	cinI	-	-	S	ko:K06889	-	ko00000	Serine hydrolase (FSH1)
HIFLEHPO_01756	4.17e-65	-	-	-	S	-	-	-	Phospholipase, patatin family
HIFLEHPO_01757	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HIFLEHPO_01758	4.44e-174	-	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
HIFLEHPO_01759	2.9e-79	-	-	-	S	-	-	-	Enterocin A Immunity
HIFLEHPO_01760	3.18e-198	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
HIFLEHPO_01761	6.63e-174	gntR	-	-	K	-	-	-	UbiC transcription regulator-associated domain protein
HIFLEHPO_01762	1.01e-222	rihC	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
HIFLEHPO_01763	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
HIFLEHPO_01764	1.82e-161	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HIFLEHPO_01765	8.52e-215	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIFLEHPO_01766	7.29e-209	-	-	-	C	-	-	-	Domain of unknown function (DUF4931)
HIFLEHPO_01767	8.94e-308	srrA1	-	-	G	ko:K02027,ko:K17244	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HIFLEHPO_01768	2.32e-127	-	-	-	S	-	-	-	Domain of unknown function (DUF4767)
HIFLEHPO_01769	1.01e-310	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HIFLEHPO_01770	2.81e-193	-	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HIFLEHPO_01771	1.31e-128	-	-	-	I	-	-	-	PAP2 superfamily
HIFLEHPO_01772	5e-227	cbh	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
HIFLEHPO_01774	4.35e-221	-	-	-	S	-	-	-	Conserved hypothetical protein 698
HIFLEHPO_01775	1.03e-34	-	-	-	S	-	-	-	Pyridoxamine 5'-phosphate oxidase
HIFLEHPO_01776	6.34e-40	-	-	-	S	-	-	-	Pyridoxamine 5'-phosphate oxidase
HIFLEHPO_01777	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	E1-E2 ATPase
HIFLEHPO_01778	4.22e-41	-	-	-	C	-	-	-	Heavy-metal-associated domain
HIFLEHPO_01779	1.45e-102	dpsB	-	-	P	-	-	-	Belongs to the Dps family
HIFLEHPO_01780	2.6e-110	fnr	-	-	K	ko:K21562	-	ko00000,ko03000	Transcriptional regulator, Crp Fnr family
HIFLEHPO_01781	1.85e-164	yobV3	-	-	K	-	-	-	WYL domain
HIFLEHPO_01782	5.61e-72	-	-	-	S	-	-	-	pyridoxamine 5-phosphate
HIFLEHPO_01783	5.68e-110	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
HIFLEHPO_01784	1.43e-33	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
HIFLEHPO_01785	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HIFLEHPO_01786	3.09e-214	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
HIFLEHPO_01787	5.62e-316	dnaB2	-	-	L	ko:K03346	-	ko00000,ko03032	Replication initiation and membrane attachment
HIFLEHPO_01788	3.04e-105	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HIFLEHPO_01789	2.16e-136	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HIFLEHPO_01790	2.24e-198	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HIFLEHPO_01791	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIFLEHPO_01792	1.05e-40	-	-	-	-	-	-	-	-
HIFLEHPO_01793	2.25e-209	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HIFLEHPO_01794	1.26e-288	B4168_4126	-	-	L	ko:K07493	-	ko00000	Transposase
HIFLEHPO_01797	4.81e-77	-	-	-	S	-	-	-	SIR2-like domain
HIFLEHPO_01798	2.08e-118	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HIFLEHPO_01799	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
HIFLEHPO_01800	5.22e-54	-	-	-	S	-	-	-	RloB-like protein
HIFLEHPO_01801	1.35e-208	-	-	-	S	ko:K06926	-	ko00000	AAA domain, putative AbiEii toxin, Type IV TA system
HIFLEHPO_01802	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	DEAD/DEAH box helicase
HIFLEHPO_01803	0.0	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_01805	1.34e-22	-	-	-	S	-	-	-	CRISPR-associated protein (Cas_Csn2)
HIFLEHPO_01806	6.94e-199	yqfL	2.7.11.33, 2.7.4.28	-	F	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HIFLEHPO_01807	4.83e-30	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
HIFLEHPO_01808	1.08e-92	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
HIFLEHPO_01809	3.51e-224	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
HIFLEHPO_01810	3.58e-129	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HIFLEHPO_01811	1.37e-216	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIFLEHPO_01812	4.11e-173	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
HIFLEHPO_01813	9.03e-229	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
HIFLEHPO_01814	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
HIFLEHPO_01815	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HIFLEHPO_01816	9e-255	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HIFLEHPO_01817	5.03e-76	-	-	-	K	-	-	-	Helix-turn-helix domain
HIFLEHPO_01818	1.17e-144	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIFLEHPO_01819	1.05e-221	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
HIFLEHPO_01820	1.11e-234	-	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_01821	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HIFLEHPO_01822	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HIFLEHPO_01823	9.39e-141	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HIFLEHPO_01824	0.0	snf	-	-	KL	-	-	-	domain protein
HIFLEHPO_01825	5.73e-153	-	-	-	-	-	-	-	-
HIFLEHPO_01826	5.04e-154	-	-	-	G	-	-	-	Antibiotic biosynthesis monooxygenase
HIFLEHPO_01827	1.13e-126	-	-	-	-	-	-	-	-
HIFLEHPO_01828	6.93e-140	-	-	-	K	-	-	-	LysR substrate binding domain
HIFLEHPO_01829	9.97e-08	-	-	-	-	-	-	-	-
HIFLEHPO_01830	1.07e-287	-	-	-	S	-	-	-	Sterol carrier protein domain
HIFLEHPO_01831	1.76e-122	citX	2.7.7.61	-	HI	ko:K05964	ko02020,map02020	ko00000,ko00001,ko01000	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HIFLEHPO_01832	4.72e-134	arcC	2.7.2.2	-	E	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	ko00000,ko00001,ko01000	Belongs to the carbamate kinase family
HIFLEHPO_01833	5.39e-84	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HIFLEHPO_01834	2.06e-298	arcA	3.5.3.6	-	E	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	ko00000,ko00001,ko01000	Arginine
HIFLEHPO_01835	6.12e-177	lysR5	-	-	K	-	-	-	LysR substrate binding domain
HIFLEHPO_01836	0.0	-	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
HIFLEHPO_01837	4.97e-64	-	-	-	S	-	-	-	Metal binding domain of Ada
HIFLEHPO_01838	0.0	lacZ	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	-beta-galactosidase
HIFLEHPO_01839	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
HIFLEHPO_01840	1.73e-209	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HIFLEHPO_01841	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
HIFLEHPO_01842	4.35e-185	lacM	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase
HIFLEHPO_01843	6.69e-239	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIFLEHPO_01844	1.16e-208	-	-	-	S	-	-	-	Nucleotidyl transferase AbiEii toxin, Type IV TA system
HIFLEHPO_01845	1.12e-136	-	-	-	K	-	-	-	Transcriptional regulator, AbiEi antitoxin
HIFLEHPO_01846	2.34e-241	-	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding protein-like domain
HIFLEHPO_01847	6.21e-116	-	-	-	V	-	-	-	HNH endonuclease
HIFLEHPO_01848	6.36e-173	-	-	-	S	-	-	-	PFAM Archaeal ATPase
HIFLEHPO_01849	5.27e-314	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HIFLEHPO_01850	1.05e-309	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HIFLEHPO_01851	5.08e-149	sipS3	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HIFLEHPO_01852	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	AAA domain (Cdc48 subfamily)
HIFLEHPO_01853	7.86e-212	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HIFLEHPO_01854	3.09e-304	pts13C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_01855	1.68e-161	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01856	0.0	ylbB	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01857	1.96e-49	-	-	-	-	-	-	-	-
HIFLEHPO_01858	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HIFLEHPO_01859	1.34e-183	lysA2	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HIFLEHPO_01860	2.5e-172	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
HIFLEHPO_01861	1.97e-227	pbpX2	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_01862	6.8e-316	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HIFLEHPO_01863	4.98e-48	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HIFLEHPO_01864	2.95e-304	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
HIFLEHPO_01865	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HIFLEHPO_01866	1.3e-26	-	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
HIFLEHPO_01867	1.42e-58	-	-	-	-	-	-	-	-
HIFLEHPO_01868	5.11e-265	-	-	-	S	-	-	-	Membrane
HIFLEHPO_01869	3.41e-107	ykuL	-	-	S	-	-	-	(CBS) domain
HIFLEHPO_01870	0.0	cadA	-	-	P	-	-	-	P-type ATPase
HIFLEHPO_01871	5.71e-263	napA	-	-	P	-	-	-	Sodium/hydrogen exchanger family
HIFLEHPO_01872	2.49e-63	-	-	-	D	ko:K19159	-	ko00000,ko02048	Antitoxin component of a toxin-antitoxin (TA) module
HIFLEHPO_01873	1.68e-55	yoeB	-	-	S	ko:K19158	-	ko00000,ko01000,ko02048	YoeB-like toxin of bacterial type II toxin-antitoxin system
HIFLEHPO_01874	0.0	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HIFLEHPO_01875	1.91e-200	mutR	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HIFLEHPO_01876	1.05e-67	-	-	-	-	-	-	-	-
HIFLEHPO_01877	3.62e-202	-	-	-	EGP	-	-	-	Major facilitator Superfamily
HIFLEHPO_01878	1.49e-141	ywdE	-	-	K	ko:K20375	ko02024,map02024	ko00000,ko00001,ko03000	Transcriptional regulator
HIFLEHPO_01879	3.43e-155	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HIFLEHPO_01880	5.14e-248	-	-	-	S	-	-	-	DUF218 domain
HIFLEHPO_01881	0.0	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01882	0.0	ppc	4.1.1.31	-	H	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HIFLEHPO_01883	5.9e-130	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HIFLEHPO_01884	1.97e-255	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein PnrA-like
HIFLEHPO_01885	4.57e-232	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein PnrA-like
HIFLEHPO_01886	0.0	mglA	3.6.3.17	-	S	ko:K02056,ko:K06400	-	ko00000,ko00002,ko01000,ko02000	ABC transporter
HIFLEHPO_01887	8.8e-262	mglC	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIFLEHPO_01888	3.63e-221	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HIFLEHPO_01889	3.08e-205	-	-	-	S	-	-	-	Aldo/keto reductase family
HIFLEHPO_01890	1.15e-173	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HIFLEHPO_01891	9.85e-154	dak	2.7.1.76	-	F	ko:K10353	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	deoxynucleoside kinase
HIFLEHPO_01892	1.06e-159	dgk2	2.7.1.76	-	F	ko:K10353	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	deoxynucleoside kinase
HIFLEHPO_01893	6.64e-94	-	-	-	-	-	-	-	-
HIFLEHPO_01894	2.56e-179	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HIFLEHPO_01895	9.69e-292	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HIFLEHPO_01896	3.85e-97	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIFLEHPO_01897	4.03e-75	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HIFLEHPO_01898	8.34e-116	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01899	7.81e-169	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HIFLEHPO_01900	1.71e-150	-	-	-	S	-	-	-	Peptidase family M23
HIFLEHPO_01901	6.57e-141	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIFLEHPO_01902	1.24e-125	-	-	-	M	-	-	-	hydrolase, family 25
HIFLEHPO_01903	3.09e-22	-	-	-	-	-	-	-	-
HIFLEHPO_01911	9.43e-300	-	-	-	S	-	-	-	Phage minor structural protein
HIFLEHPO_01913	2.94e-166	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
HIFLEHPO_01914	4.55e-221	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
HIFLEHPO_01915	5e-53	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
HIFLEHPO_01916	3.88e-52	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
HIFLEHPO_01917	0.0	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HIFLEHPO_01918	8.32e-128	yjcK	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HIFLEHPO_01919	3.2e-143	-	-	-	S	-	-	-	SNARE associated Golgi protein
HIFLEHPO_01920	1.52e-195	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HIFLEHPO_01921	2.71e-200	plcR	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix
HIFLEHPO_01922	2.73e-107	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
HIFLEHPO_01923	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HIFLEHPO_01924	7.51e-205	-	-	-	-	-	-	-	-
HIFLEHPO_01925	4.76e-248	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HIFLEHPO_01926	4.59e-124	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
HIFLEHPO_01927	3.69e-171	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
HIFLEHPO_01928	8.72e-111	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HIFLEHPO_01929	4.27e-167	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
HIFLEHPO_01930	3.05e-200	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HIFLEHPO_01931	1.4e-80	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
HIFLEHPO_01932	8.4e-199	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HIFLEHPO_01933	1.58e-70	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
HIFLEHPO_01934	1.15e-146	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HIFLEHPO_01935	1.18e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
HIFLEHPO_01936	9.21e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIFLEHPO_01937	6.31e-68	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HIFLEHPO_01938	4.55e-106	-	-	-	M	-	-	-	family 8
HIFLEHPO_01939	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIFLEHPO_01940	1.08e-117	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HIFLEHPO_01941	4.22e-211	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
HIFLEHPO_01942	3.65e-141	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01943	7.42e-123	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_01944	8.69e-190	glnH	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HIFLEHPO_01945	1.19e-174	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01946	1.24e-144	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Zeta toxin
HIFLEHPO_01947	0.0	-	-	-	G	-	-	-	MFS/sugar transport protein
HIFLEHPO_01948	7.3e-131	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
HIFLEHPO_01949	0.0	XK27_09605	-	-	V	ko:K18892	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter transmembrane region
HIFLEHPO_01950	0.0	XK27_09600	-	-	V	ko:K06147,ko:K18891	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_01951	2.53e-106	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
HIFLEHPO_01952	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_01953	1.28e-228	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HIFLEHPO_01954	1.75e-168	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HIFLEHPO_01955	2.37e-242	-	-	-	T	-	-	-	GHKL domain
HIFLEHPO_01956	2.88e-98	ykoJ	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HIFLEHPO_01957	5.59e-109	-	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HIFLEHPO_01958	8e-108	XK27_03150	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HIFLEHPO_01959	8.64e-85	yybA	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_01960	2.91e-83	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter transmembrane region
HIFLEHPO_01961	1.13e-201	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter transmembrane region
HIFLEHPO_01962	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HIFLEHPO_01963	6.95e-29	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
HIFLEHPO_01964	1.27e-311	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HIFLEHPO_01965	8.12e-60	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HIFLEHPO_01966	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
HIFLEHPO_01967	6.98e-78	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
HIFLEHPO_01968	1.39e-224	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIFLEHPO_01969	6.22e-232	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
HIFLEHPO_01970	4.43e-179	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
HIFLEHPO_01971	1.51e-154	-	-	-	C	-	-	-	2Fe-2S iron-sulfur cluster binding domain
HIFLEHPO_01972	1.24e-188	-	5.2.1.13	-	Q	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	ko00000,ko00001,ko00002,ko01000	HI0933-like protein
HIFLEHPO_01973	7.13e-67	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
HIFLEHPO_01974	8.8e-207	-	-	-	L	-	-	-	HNH nucleases
HIFLEHPO_01975	1.11e-154	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
HIFLEHPO_01976	2.59e-225	-	-	-	G	-	-	-	Glycosyl hydrolases family 8
HIFLEHPO_01977	8.22e-240	-	-	-	M	-	-	-	Glycosyl transferase
HIFLEHPO_01978	1.34e-09	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
HIFLEHPO_01979	9.69e-25	-	-	-	-	-	-	-	-
HIFLEHPO_01980	0.0	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Membrane domain of glycerophosphoryl diester phosphodiesterase
HIFLEHPO_01981	3.34e-92	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HIFLEHPO_01982	7.23e-244	ysdE	-	-	P	-	-	-	Citrate transporter
HIFLEHPO_01983	6.78e-124	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
HIFLEHPO_01984	1.64e-207	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
HIFLEHPO_01985	1.05e-222	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HIFLEHPO_01986	9.73e-132	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HIFLEHPO_01987	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
HIFLEHPO_01988	1.12e-267	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HIFLEHPO_01989	9.94e-71	ylbG	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
HIFLEHPO_01990	5.21e-126	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
HIFLEHPO_01991	7.07e-107	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HIFLEHPO_01992	5.76e-244	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
HIFLEHPO_01993	2.7e-126	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
HIFLEHPO_01994	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
HIFLEHPO_01995	1.23e-225	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
HIFLEHPO_01996	1.17e-103	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HIFLEHPO_01997	8.08e-281	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HIFLEHPO_01998	3.66e-225	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIFLEHPO_01999	6.89e-185	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HIFLEHPO_02000	7.42e-276	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIFLEHPO_02001	1.05e-253	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HIFLEHPO_02002	4.2e-249	pbpX1	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_02003	0.0	-	-	-	I	-	-	-	Protein of unknown function (DUF2974)
HIFLEHPO_02004	3.04e-53	-	-	-	C	-	-	-	FMN_bind
HIFLEHPO_02005	3.85e-109	-	-	-	-	-	-	-	-
HIFLEHPO_02006	1.16e-13	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
HIFLEHPO_02007	2.43e-118	-	2.7.7.49	-	L	ko:K00986	-	ko00000,ko01000	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
HIFLEHPO_02008	1.91e-103	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HIFLEHPO_02009	3.61e-288	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
HIFLEHPO_02010	3.05e-110	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
HIFLEHPO_02011	3.68e-176	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIFLEHPO_02013	3.68e-177	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_02014	2.24e-71	ykoJ	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HIFLEHPO_02015	2.36e-213	adh2	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
HIFLEHPO_02016	2.33e-230	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal
HIFLEHPO_02017	2.9e-255	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
HIFLEHPO_02018	2.32e-86	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
HIFLEHPO_02019	2.19e-270	XK27_05220	-	-	S	-	-	-	AI-2E family transporter
HIFLEHPO_02020	2.12e-136	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HIFLEHPO_02021	3.12e-91	-	-	-	S	-	-	-	Protein of unknown function (DUF1149)
HIFLEHPO_02022	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HIFLEHPO_02023	4.2e-284	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
HIFLEHPO_02024	1.06e-298	ymfH	-	-	S	-	-	-	Peptidase M16
HIFLEHPO_02025	1.39e-171	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HIFLEHPO_02026	1.63e-154	ymfM	-	-	S	ko:K15539	-	ko00000	Helix-turn-helix domain
HIFLEHPO_02027	3.92e-123	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIFLEHPO_02028	1.17e-248	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HIFLEHPO_02029	3.52e-292	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
HIFLEHPO_02030	1.94e-268	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	transferase
HIFLEHPO_02031	5.04e-154	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
HIFLEHPO_02032	2.68e-314	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
HIFLEHPO_02033	9.44e-169	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
HIFLEHPO_02034	1.55e-122	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HIFLEHPO_02035	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HIFLEHPO_02036	2.24e-238	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HIFLEHPO_02037	8.33e-27	-	-	-	-	-	-	-	-
HIFLEHPO_02038	3.54e-230	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HIFLEHPO_02039	4.04e-203	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HIFLEHPO_02040	3.31e-239	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
HIFLEHPO_02041	3.42e-232	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HIFLEHPO_02042	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HIFLEHPO_02043	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HIFLEHPO_02044	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HIFLEHPO_02045	1.55e-117	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HIFLEHPO_02046	8.18e-210	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
HIFLEHPO_02047	1.61e-250	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
HIFLEHPO_02048	8.59e-221	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
HIFLEHPO_02049	1.16e-128	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HIFLEHPO_02050	0.0	-	-	-	S	-	-	-	SH3-like domain
HIFLEHPO_02051	3.16e-144	ybbL	-	-	S	ko:K02068	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_02052	2.75e-167	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	Uncharacterised protein family (UPF0014)
HIFLEHPO_02053	5.35e-121	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HIFLEHPO_02054	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HIFLEHPO_02055	5.38e-101	-	-	-	K	-	-	-	MerR HTH family regulatory protein
HIFLEHPO_02056	3.23e-149	-	-	-	V	ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_02057	6.46e-119	cylB	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
HIFLEHPO_02058	3.8e-60	-	-	-	K	-	-	-	LytTr DNA-binding domain
HIFLEHPO_02059	3.87e-43	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
HIFLEHPO_02060	5.21e-181	-	-	-	S	-	-	-	Cysteine-rich secretory protein family
HIFLEHPO_02061	0.0	ycaM	-	-	E	-	-	-	amino acid
HIFLEHPO_02062	0.0	-	-	-	-	-	-	-	-
HIFLEHPO_02064	9.53e-241	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	Putative sugar-binding domain
HIFLEHPO_02065	2.86e-244	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HIFLEHPO_02066	2.86e-286	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
HIFLEHPO_02067	5.46e-183	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HIFLEHPO_02068	5.27e-236	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
HIFLEHPO_02069	8.39e-151	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
HIFLEHPO_02070	2.15e-137	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
HIFLEHPO_02071	1.1e-184	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HIFLEHPO_02072	3.75e-135	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
HIFLEHPO_02073	0.0	sasH	3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45	-	F	ko:K01081,ko:K01119,ko:K07004,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HIFLEHPO_02074	9.89e-74	-	-	-	-	-	-	-	-
HIFLEHPO_02075	0.0	-	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HIFLEHPO_02076	1.23e-231	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
HIFLEHPO_02077	1.13e-272	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HIFLEHPO_02078	3.7e-113	gtcA1	-	-	S	-	-	-	Teichoic acid glycosylation protein
HIFLEHPO_02079	5.14e-105	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HIFLEHPO_02080	2.45e-211	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
HIFLEHPO_02081	1.99e-208	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
HIFLEHPO_02082	3.22e-215	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HIFLEHPO_02083	2.12e-273	atoB	1.1.1.88, 2.3.1.9	-	I	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HIFLEHPO_02084	8.22e-270	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
HIFLEHPO_02085	2.49e-277	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
HIFLEHPO_02086	0.0	-	-	-	L	-	-	-	Transposase
HIFLEHPO_02087	2.27e-71	-	-	-	S	-	-	-	protein encoded in hypervariable junctions of pilus gene clusters
HIFLEHPO_02088	7.26e-35	-	-	-	S	-	-	-	Protein conserved in bacteria
HIFLEHPO_02089	1.09e-74	-	-	-	-	-	-	-	-
HIFLEHPO_02090	8.23e-112	-	-	-	-	-	-	-	-
HIFLEHPO_02091	0.0	yheS_2	-	-	S	ko:K18231,ko:K19349	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ATPases associated with a variety of cellular activities
HIFLEHPO_02092	5.74e-185	-	-	-	S	-	-	-	DUF218 domain
HIFLEHPO_02093	1.06e-141	-	-	-	-	-	-	-	-
HIFLEHPO_02094	7.81e-107	-	-	-	-	-	-	-	-
HIFLEHPO_02095	1.28e-106	yicL	-	-	EG	-	-	-	EamA-like transporter family
HIFLEHPO_02096	6.7e-211	-	-	-	EG	-	-	-	EamA-like transporter family
HIFLEHPO_02097	5.7e-209	-	-	-	EG	-	-	-	EamA-like transporter family
HIFLEHPO_02098	2.52e-52	-	-	-	-	-	-	-	-
HIFLEHPO_02099	1.2e-202	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HIFLEHPO_02100	0.0	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	amino acid
HIFLEHPO_02101	0.0	-	-	-	L	-	-	-	Helicase C-terminal domain protein
HIFLEHPO_02102	1.36e-260	pbpX	-	-	V	-	-	-	Beta-lactamase
HIFLEHPO_02103	1.05e-289	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
HIFLEHPO_02104	1.77e-93	def2	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
HIFLEHPO_02105	6.03e-218	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
HIFLEHPO_02106	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
HIFLEHPO_02107	5.6e-129	-	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
HIFLEHPO_02108	2.23e-197	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HIFLEHPO_02109	7.92e-306	dacA	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HIFLEHPO_02111	1.59e-61	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain
HIFLEHPO_02112	3.54e-300	-	-	-	L	ko:K07497	-	ko00000	COG2963 Transposase and inactivated derivatives
HIFLEHPO_02113	6.56e-118	-	-	-	V	-	-	-	ABC transporter transmembrane region
HIFLEHPO_02114	2.27e-179	-	-	-	-	-	-	-	-
HIFLEHPO_02118	1.95e-46	-	-	-	-	-	-	-	-
HIFLEHPO_02119	2.52e-76	-	-	-	S	-	-	-	Cupredoxin-like domain
HIFLEHPO_02120	4.44e-65	-	-	-	S	-	-	-	Cupredoxin-like domain
HIFLEHPO_02121	0.0	copA	3.6.3.3, 3.6.3.5, 3.6.3.54	-	P	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
HIFLEHPO_02122	6.63e-147	crp2	-	-	K	ko:K10914,ko:K21562	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	helix_turn_helix, cAMP Regulatory protein
HIFLEHPO_02123	7.41e-136	-	-	-	-	-	-	-	-
HIFLEHPO_02124	1.03e-65	-	-	-	EGP	ko:K08368	-	ko00000,ko02000	Sugar (and other) transporter
HIFLEHPO_02125	5.06e-111	-	-	-	-	-	-	-	-
HIFLEHPO_02126	0.0	-	-	-	-	-	-	-	-
HIFLEHPO_02127	2.65e-107	-	-	-	S	-	-	-	Fic/DOC family
HIFLEHPO_02128	0.0	potE	-	-	E	-	-	-	Amino Acid
HIFLEHPO_02129	2.44e-285	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIFLEHPO_02130	1.22e-310	lctO	1.13.12.4	-	C	ko:K00467,ko:K10530	ko00620,map00620	ko00000,ko00001,ko01000	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
HIFLEHPO_02131	6.66e-41	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HIFLEHPO_02132	1.61e-70	-	-	-	-	-	-	-	-
HIFLEHPO_02133	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
HIFLEHPO_02134	3.16e-102	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HIFLEHPO_02135	2.28e-221	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HIFLEHPO_02136	9.73e-254	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HIFLEHPO_02137	0.0	carB1	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HIFLEHPO_02138	1.17e-110	yfhC	-	-	C	-	-	-	nitroreductase
HIFLEHPO_02139	1.22e-174	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
HIFLEHPO_02140	0.0	pbg6	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIFLEHPO_02141	1.8e-284	pts23C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HIFLEHPO_02142	5.73e-154	-	-	-	K	ko:K03492	-	ko00000,ko03000	UTRA
HIFLEHPO_02143	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIFLEHPO_02144	4.04e-94	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HIFLEHPO_02145	5.74e-69	-	-	-	-	-	-	-	-
HIFLEHPO_02146	7.51e-174	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
HIFLEHPO_02147	1.38e-144	tal	2.2.1.2	-	H	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase/Fructose-6-phosphate aldolase
HIFLEHPO_02148	0.0	-	-	-	G	-	-	-	PTS system sorbose-specific iic component
HIFLEHPO_02149	3.59e-69	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HIFLEHPO_02150	5.36e-100	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HIFLEHPO_02152	1.77e-189	yxeH	-	-	S	-	-	-	hydrolase
HIFLEHPO_02153	6.32e-41	-	-	-	S	-	-	-	reductase
HIFLEHPO_02154	2.98e-50	-	-	-	S	-	-	-	reductase
HIFLEHPO_02155	1.19e-43	-	-	-	S	-	-	-	reductase
HIFLEHPO_02156	3.82e-276	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIFLEHPO_02158	9.14e-283	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HIFLEHPO_02159	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HIFLEHPO_02160	2.03e-310	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
HIFLEHPO_02161	1.8e-99	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HIFLEHPO_02162	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIFLEHPO_02163	6.77e-49	-	-	-	-	-	-	-	-
HIFLEHPO_02164	1.38e-223	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
HIFLEHPO_02165	1.85e-115	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIFLEHPO_02166	7.7e-21	-	-	-	-	-	-	-	-
HIFLEHPO_02167	1.51e-44	-	-	-	-	-	-	-	-
HIFLEHPO_02169	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
HIFLEHPO_02170	1.05e-226	citR	-	-	K	-	-	-	Putative sugar-binding domain
HIFLEHPO_02171	2.93e-67	-	-	-	-	-	-	-	-
HIFLEHPO_02172	7.91e-14	-	-	-	-	-	-	-	-
HIFLEHPO_02173	8.1e-87	-	-	-	S	-	-	-	Domain of unknown function DUF1828
HIFLEHPO_02174	5.38e-125	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
HIFLEHPO_02175	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_02176	3.51e-187	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
HIFLEHPO_02177	1.46e-31	-	-	-	-	-	-	-	-
HIFLEHPO_02178	7.19e-93	ytwI	-	-	S	-	-	-	Protein of unknown function (DUF441)
HIFLEHPO_02179	0.0	citF	2.8.3.10	-	H	ko:K01643	ko02020,map02020	ko00000,ko00001,ko01000	Citrate (pro-3S)-lyase alpha chain
HIFLEHPO_02180	3.46e-212	citE	4.1.3.34	-	G	ko:K01644	ko02020,map02020	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
HIFLEHPO_02181	1.6e-59	citD	-	-	C	ko:K01646	ko02020,map02020	ko00000,ko00001	Covalent carrier of the coenzyme of citrate lyase
HIFLEHPO_02182	5.17e-249	citC	6.2.1.22	-	H	ko:K01910	ko02020,map02020	ko00000,ko00001,ko01000	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HIFLEHPO_02183	8.12e-195	-	-	-	I	-	-	-	Alpha/beta hydrolase family
HIFLEHPO_02184	0.0	citP	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
HIFLEHPO_02185	5.26e-171	-	-	-	H	-	-	-	Aldolase/RraA
HIFLEHPO_02186	0.0	pepC4	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
HIFLEHPO_02187	1.66e-217	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HIFLEHPO_02188	0.0	frdA	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
HIFLEHPO_02189	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HIFLEHPO_02190	2.34e-122	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_02191	5.74e-243	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIFLEHPO_02192	4.37e-205	metQ	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HIFLEHPO_02193	1.33e-225	-	-	-	F	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
HIFLEHPO_02194	0.0	aha1	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
HIFLEHPO_02195	5.55e-119	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HIFLEHPO_02196	3.53e-228	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HIFLEHPO_02197	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HIFLEHPO_02198	8.44e-306	-	-	-	V	ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HIFLEHPO_02199	0.0	-	-	-	P	ko:K06148	-	ko00000,ko02000	ABC transporter
HIFLEHPO_02200	6.04e-49	-	-	-	-	-	-	-	-
HIFLEHPO_02202	1.46e-161	-	-	-	S	-	-	-	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
HIFLEHPO_02203	7.94e-114	-	-	-	K	-	-	-	GNAT family
HIFLEHPO_02204	3.7e-258	XK27_00915	-	-	C	-	-	-	Luciferase-like monooxygenase
HIFLEHPO_02205	1.98e-191	yhaH	-	-	S	-	-	-	Protein of unknown function (DUF805)
HIFLEHPO_02206	2.89e-173	glnQ	-	-	E	ko:K17076	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_02207	0.0	XK27_05795	-	-	P	ko:K17073,ko:K17074	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HIFLEHPO_02208	1.41e-155	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
HIFLEHPO_02209	1.54e-84	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
HIFLEHPO_02210	9.4e-164	terC	-	-	P	-	-	-	Integral membrane protein TerC family
HIFLEHPO_02211	5.09e-119	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	6-O-methylguanine DNA methyltransferase, DNA binding domain
HIFLEHPO_02212	1.24e-169	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	SIR2 family
HIFLEHPO_02213	1.44e-62	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HIFLEHPO_02214	1.64e-169	adh2	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
HIFLEHPO_02215	1.17e-87	-	-	-	GM	-	-	-	NAD(P)H-binding
HIFLEHPO_02216	6.46e-44	-	-	-	S	-	-	-	Domain of unknown function (DUF4440)
HIFLEHPO_02217	3.49e-113	-	-	-	K	-	-	-	LysR substrate binding domain
HIFLEHPO_02219	2.25e-57	-	-	-	K	-	-	-	Tetracycline repressor, C-terminal all-alpha domain
HIFLEHPO_02220	5.94e-100	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
HIFLEHPO_02222	3.35e-269	-	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HIFLEHPO_02223	4.36e-142	XK27_00160	-	-	S	-	-	-	Domain of unknown function (DUF5052)
HIFLEHPO_02224	1.5e-90	-	-	-	-	-	-	-	-
HIFLEHPO_02225	1.24e-258	xerS	-	-	L	ko:K03733	-	ko00000,ko03036	Belongs to the 'phage' integrase family
HIFLEHPO_02226	0.0	mutS1	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HIFLEHPO_02227	1.28e-292	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HIFLEHPO_02228	8.73e-187	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HIFLEHPO_02229	9.01e-287	-	-	-	S	ko:K07133	-	ko00000	cog cog1373
HIFLEHPO_02230	3.87e-80	yneE	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_02231	2.18e-122	yneE	-	-	K	-	-	-	Transcriptional regulator
HIFLEHPO_02232	3.58e-61	-	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
HIFLEHPO_02233	5.05e-11	-	-	-	-	-	-	-	-
HIFLEHPO_02234	3.69e-54	-	-	-	L	ko:K07473	-	ko00000,ko02048	Addiction module antitoxin, RelB DinJ family
HIFLEHPO_02235	8.74e-146	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HIFLEHPO_02236	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
HIFLEHPO_02237	0.0	spxB	1.2.3.3, 1.2.5.1, 2.2.1.6, 4.1.1.8	-	EH	ko:K00156,ko:K00158,ko:K01577,ko:K01652	ko00290,ko00620,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HIFLEHPO_02238	9.48e-261	frc	2.8.3.16	-	C	ko:K07749	-	ko00000,ko01000	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
HIFLEHPO_02239	3.06e-53	bbsF_1	2.8.3.19	-	C	ko:K18702	-	ko00000,ko01000	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
HIFLEHPO_02240	2.18e-112	-	-	-	GKT	-	-	-	domain protein
HIFLEHPO_02241	0.0	-	3.2.1.170, 3.2.1.24	GH38	G	ko:K01191,ko:K15524	ko00511,map00511	ko00000,ko00001,ko01000,ko04131	Glycosyl hydrolases family 38 N-terminal domain
HIFLEHPO_02242	4.34e-198	fptC	-	-	U	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	system, fructose-specific IIC component
HIFLEHPO_02243	5.84e-50	-	-	-	G	-	-	-	Psort location Cytoplasmic, score 9.98
HIFLEHPO_02244	2.4e-54	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HIFLEHPO_02245	1.45e-183	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
HIFLEHPO_02246	8.05e-180	-	-	-	S	ko:K06889	-	ko00000	Alpha/beta hydrolase family
HIFLEHPO_02247	2.75e-143	-	-	-	G	-	-	-	phosphoglycerate mutase
HIFLEHPO_02248	1.45e-119	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HIFLEHPO_02249	1.05e-233	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HIFLEHPO_02250	2.12e-132	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_02251	0.0	pepD4	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HIFLEHPO_02252	2.14e-138	-	-	-	D	-	-	-	Ftsk spoiiie family protein
HIFLEHPO_02253	1.74e-185	-	-	-	S	-	-	-	Replication initiation factor
HIFLEHPO_02254	1.33e-72	-	-	-	-	-	-	-	-
HIFLEHPO_02255	4.04e-36	-	-	-	-	-	-	-	-
HIFLEHPO_02256	3.5e-280	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HIFLEHPO_02258	9.75e-80	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HIFLEHPO_02259	8.25e-65	-	-	-	V	ko:K01990,ko:K01992	-	ko00000,ko00002,ko02000	Transport permease protein
HIFLEHPO_02261	2.36e-157	aapA	-	-	M	-	-	-	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HIFLEHPO_02262	7.44e-129	-	-	-	L	-	-	-	An automated process has identified a potential problem with this gene model
HIFLEHPO_02263	4.1e-34	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIFLEHPO_02264	5.34e-77	tnpR1	-	-	L	-	-	-	Resolvase, N terminal domain
HIFLEHPO_02265	4.22e-185	-	-	-	M	-	-	-	Rib/alpha-like repeat
HIFLEHPO_02266	1.15e-121	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HIFLEHPO_02267	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HIFLEHPO_02268	7e-131	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	sortase family
HIFLEHPO_02269	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HIFLEHPO_02270	5.88e-278	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HIFLEHPO_02271	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
HIFLEHPO_02272	3.74e-109	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HIFLEHPO_02273	1.48e-247	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HIFLEHPO_02274	5.35e-223	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
HIFLEHPO_02275	1.64e-198	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIFLEHPO_02276	1.67e-79	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HIFLEHPO_02277	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HIFLEHPO_02278	1.61e-64	ylxQ	-	-	J	-	-	-	ribosomal protein
HIFLEHPO_02279	3.75e-63	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
HIFLEHPO_02280	1.19e-259	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
HIFLEHPO_02281	3.4e-108	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
HIFLEHPO_02282	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIFLEHPO_02283	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HIFLEHPO_02284	6.38e-254	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
HIFLEHPO_02285	3.93e-181	cdsA	2.7.7.41	-	I	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
HIFLEHPO_02286	6.38e-178	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIFLEHPO_02287	8.22e-120	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HIFLEHPO_02288	5.86e-168	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
HIFLEHPO_02289	1.76e-235	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HIFLEHPO_02290	2.21e-180	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
HIFLEHPO_02291	2.03e-251	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
HIFLEHPO_02292	1.65e-151	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
HIFLEHPO_02293	4.94e-292	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
HIFLEHPO_02294	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HIFLEHPO_02295	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_02296	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HIFLEHPO_02297	1.3e-40	XK26_06720	-	-	S	ko:K09976	-	ko00000	Uncharacterised protein family (UPF0154)
HIFLEHPO_02298	4.16e-51	ynzC	-	-	S	-	-	-	UPF0291 protein
HIFLEHPO_02299	9.86e-146	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIFLEHPO_02300	7.18e-187	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
HIFLEHPO_02301	1.15e-154	ung2	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil-DNA glycosylase
HIFLEHPO_02302	4.96e-270	-	-	-	S	-	-	-	SLAP domain
HIFLEHPO_02303	1.64e-74	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HIFLEHPO_02304	1.63e-173	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
HIFLEHPO_02305	2.08e-122	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIFLEHPO_02306	6.78e-60	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
HIFLEHPO_02307	2.32e-290	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIFLEHPO_02308	5.56e-72	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HIFLEHPO_02309	0.0	ctrA	-	-	E	ko:K03294	-	ko00000	amino acid
HIFLEHPO_02310	1.68e-44	-	-	-	G	-	-	-	Peptidase_C39 like family
HIFLEHPO_02311	9.23e-209	-	-	-	M	-	-	-	NlpC/P60 family
HIFLEHPO_02312	8.19e-116	-	-	-	G	-	-	-	Peptidase_C39 like family
HIFLEHPO_02313	1.09e-223	pepI	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HIFLEHPO_02314	2.05e-115	-	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
HIFLEHPO_02315	0.0	-	-	-	S	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HIFLEHPO_02316	1.58e-101	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HIFLEHPO_02317	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HIFLEHPO_02318	1.3e-40	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HIFLEHPO_02319	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HIFLEHPO_02320	5.18e-128	-	-	-	G	-	-	-	Aldose 1-epimerase
HIFLEHPO_02321	9.78e-257	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HIFLEHPO_02322	1.03e-145	plsY1	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HIFLEHPO_02323	0.0	XK27_08315	-	-	M	-	-	-	Sulfatase
HIFLEHPO_02324	4.46e-226	iunH	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	inosine-uridine preferring nucleoside hydrolase
HIFLEHPO_02325	1.01e-116	alkD	-	-	L	-	-	-	DNA alkylation repair enzyme
HIFLEHPO_02326	0.0	pbg4	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HIFLEHPO_02327	1.33e-165	-	-	-	K	ko:K03492	-	ko00000,ko03000	UTRA domain
HIFLEHPO_02328	1.32e-74	pts20B	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HIFLEHPO_02329	4.56e-78	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose Cellobiose specific IIA subunit
HIFLEHPO_02330	2.72e-15	-	-	-	-	-	-	-	-
HIFLEHPO_02331	2.36e-12	-	-	-	S	-	-	-	Bacteriophage abortive infection AbiH
HIFLEHPO_02332	0.0	sacB	2.4.1.10, 2.4.1.9	GH68	M	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	Levansucrase/Invertase
HIFLEHPO_02336	5.5e-155	-	-	-	-	-	-	-	-
HIFLEHPO_02337	9.18e-202	-	-	-	C	-	-	-	Domain of unknown function (DUF4931)
HIFLEHPO_02338	3.58e-251	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HIFLEHPO_02339	2.61e-23	-	-	-	-	-	-	-	-
HIFLEHPO_02340	1.05e-119	-	-	-	S	-	-	-	membrane
HIFLEHPO_02341	6.45e-93	-	-	-	K	-	-	-	LytTr DNA-binding domain
HIFLEHPO_02344	7.63e-43	-	-	-	K	ko:K03484	-	ko00000,ko03000	Periplasmic binding protein domain
HIFLEHPO_02345	2.51e-52	-	-	-	K	ko:K03484	-	ko00000,ko03000	Periplasmic binding protein domain
HIFLEHPO_02346	0.0	pulA	3.2.1.41	CBM48,GH13	G	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko01000	belongs to the glycosyl hydrolase 13 family
HIFLEHPO_02347	1.2e-199	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
HIFLEHPO_02348	1.05e-45	-	-	-	-	-	-	-	-
HIFLEHPO_02349	0.0	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative DNA-binding domain
HIFLEHPO_02350	1.66e-303	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
HIFLEHPO_02351	1.51e-117	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HIFLEHPO_02352	2.13e-151	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HIFLEHPO_02353	6.51e-69	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HIFLEHPO_02354	9.01e-198	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
HIFLEHPO_02355	9.46e-159	-	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
HIFLEHPO_02356	1.87e-58	-	-	-	-	-	-	-	-
HIFLEHPO_02357	0.0	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
HIFLEHPO_02358	1.47e-303	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HIFLEHPO_02359	3.46e-32	-	-	-	S	-	-	-	Alpha beta hydrolase
HIFLEHPO_02360	0.0	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
HIFLEHPO_02361	7.1e-136	ybbB	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HIFLEHPO_02362	5.22e-45	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
HIFLEHPO_02363	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HIFLEHPO_02364	3.07e-235	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HIFLEHPO_02365	0.0	-	-	-	L	-	-	-	Nuclease-related domain
HIFLEHPO_02366	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HIFLEHPO_02367	2.31e-148	-	-	-	S	-	-	-	repeat protein
HIFLEHPO_02368	4.7e-163	pgm	-	-	G	-	-	-	Phosphoglycerate mutase family
HIFLEHPO_02369	4.47e-278	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HIFLEHPO_02370	9.98e-75	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
HIFLEHPO_02371	1.62e-276	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HIFLEHPO_02372	2.05e-163	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIFLEHPO_02373	1.22e-55	-	-	-	-	-	-	-	-
HIFLEHPO_02374	4.26e-133	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
HIFLEHPO_02375	2.32e-43	cspA	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
HIFLEHPO_02376	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIFLEHPO_02377	6.3e-138	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA domain protein
HIFLEHPO_02378	4.68e-191	ylmH	-	-	S	-	-	-	S4 domain protein
HIFLEHPO_02379	2.42e-60	yggT	-	-	S	ko:K02221	-	ko00000,ko02044	YGGT family
HIFLEHPO_02380	1.43e-96	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HIFLEHPO_02381	2.52e-300	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIFLEHPO_02382	1.54e-309	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HIFLEHPO_02383	3.14e-194	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HIFLEHPO_02384	1.65e-265	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HIFLEHPO_02385	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HIFLEHPO_02386	4.43e-224	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HIFLEHPO_02387	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HIFLEHPO_02388	6.55e-72	ftsL	-	-	D	-	-	-	Cell division protein FtsL
HIFLEHPO_02389	1.49e-223	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HIFLEHPO_02390	5.63e-102	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
HIFLEHPO_02391	1.02e-72	-	-	-	S	-	-	-	Protein of unknown function (DUF3397)
HIFLEHPO_02392	1.4e-09	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
HIFLEHPO_02393	5.43e-122	mreD	-	-	-	ko:K03571	-	ko00000,ko03036	-
HIFLEHPO_02394	8.27e-189	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
HIFLEHPO_02395	8.26e-226	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
HIFLEHPO_02396	6.18e-150	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
HIFLEHPO_02397	1.06e-162	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HIFLEHPO_02398	1.22e-306	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HIFLEHPO_02399	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HIFLEHPO_02400	2.91e-67	-	-	-	-	-	-	-	-
HIFLEHPO_02401	1.73e-165	-	-	-	S	ko:K06926	-	ko00000	AAA domain, putative AbiEii toxin, Type IV TA system
HIFLEHPO_02402	0.0	yoaB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HIFLEHPO_02403	9.25e-13	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_02404	2.09e-59	-	-	-	-	-	-	-	-
HIFLEHPO_02405	3.33e-123	-	-	-	S	-	-	-	Protein of unknown function (DUF3990)
HIFLEHPO_02406	1.73e-219	yfdH	-	GT2	M	ko:K12999	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HIFLEHPO_02407	1.06e-86	-	-	-	S	-	-	-	GtrA-like protein
HIFLEHPO_02408	3.97e-57	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
HIFLEHPO_02409	6.01e-153	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HIFLEHPO_02410	1.51e-123	-	3.6.4.12	-	K	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Putative ATP-dependent DNA helicase recG C-terminal