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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
NLIIHIGN_00001	6.81e-172	-	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
NLIIHIGN_00002	2.68e-127	-	-	-	S	-	-	-	Protein of unknown function (DUF1700)
NLIIHIGN_00003	2.79e-75	XK27_06915	-	-	K	ko:K10947	-	ko00000,ko03000	transcriptional regulator PadR family
NLIIHIGN_00004	1.9e-61	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
NLIIHIGN_00006	2.39e-64	-	-	-	-	-	-	-	-
NLIIHIGN_00007	7.11e-57	-	-	-	S	ko:K09790	-	ko00000	Protein of unknown function (DUF454)
NLIIHIGN_00008	5.07e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
NLIIHIGN_00009	2.7e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
NLIIHIGN_00010	3.57e-150	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
NLIIHIGN_00011	5.57e-214	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
NLIIHIGN_00012	5.02e-29	-	-	-	-	-	-	-	-
NLIIHIGN_00013	0.0	-	-	-	I	-	-	-	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLIIHIGN_00014	1.37e-215	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
NLIIHIGN_00015	6.9e-134	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
NLIIHIGN_00016	6.13e-100	XK27_04775	-	-	S	ko:K09155	-	ko00000	PAS domain
NLIIHIGN_00017	2.97e-306	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NLIIHIGN_00018	4.45e-47	-	-	-	-	-	-	-	-
NLIIHIGN_00019	5.41e-73	-	-	-	S	-	-	-	Mazg nucleotide pyrophosphohydrolase
NLIIHIGN_00020	1.31e-206	xth	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
NLIIHIGN_00021	4.28e-153	-	-	-	H	-	-	-	RibD C-terminal domain
NLIIHIGN_00022	5.46e-207	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
NLIIHIGN_00023	1.29e-176	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
NLIIHIGN_00024	4.42e-216	-	-	-	C	-	-	-	Aldo keto reductase
NLIIHIGN_00025	5.2e-189	eutJ	-	-	E	ko:K04024	-	ko00000	Hsp70 protein
NLIIHIGN_00026	4.17e-174	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
NLIIHIGN_00027	3.48e-133	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
NLIIHIGN_00028	1.56e-125	-	-	-	S	-	-	-	reductase
NLIIHIGN_00029	1.08e-288	dhaT	1.1.1.202	-	C	ko:K00086	ko00561,ko00640,map00561,map00640	ko00000,ko00001,ko01000	Dehydrogenase
NLIIHIGN_00030	8.4e-200	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
NLIIHIGN_00031	1.52e-192	-	-	-	E	-	-	-	Glyoxalase-like domain
NLIIHIGN_00032	2.13e-189	-	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLIIHIGN_00033	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
NLIIHIGN_00034	1.06e-202	hlyD3	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NLIIHIGN_00035	1.69e-167	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
NLIIHIGN_00036	9.04e-278	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
NLIIHIGN_00038	6.49e-23	-	-	-	-	-	-	-	-
NLIIHIGN_00039	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
NLIIHIGN_00042	1.37e-35	-	2.7.13.3	-	T	ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
NLIIHIGN_00043	6.86e-98	-	-	-	O	-	-	-	OsmC-like protein
NLIIHIGN_00044	5.24e-232	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLIIHIGN_00045	2.83e-282	-	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
NLIIHIGN_00046	8.68e-44	-	-	-	-	-	-	-	-
NLIIHIGN_00047	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	associated with various cellular activities
NLIIHIGN_00049	1.22e-139	-	-	-	K	-	-	-	PFAM GCN5-related N-acetyltransferase
NLIIHIGN_00050	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLIIHIGN_00051	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
NLIIHIGN_00052	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
NLIIHIGN_00053	9.34e-225	malR1	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator, LacI family
NLIIHIGN_00054	4.84e-277	atoB	1.1.1.88, 2.3.1.9	-	I	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
NLIIHIGN_00055	0.0	malT	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
NLIIHIGN_00056	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
NLIIHIGN_00057	4.32e-155	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	beta-phosphoglucomutase
NLIIHIGN_00058	2.46e-93	-	-	-	-	-	-	-	-
NLIIHIGN_00059	2.92e-111	-	-	-	T	-	-	-	Region found in RelA / SpoT proteins
NLIIHIGN_00060	1.1e-153	dltr	-	-	K	-	-	-	response regulator
NLIIHIGN_00061	5.59e-290	sptS	-	-	T	-	-	-	Histidine kinase
NLIIHIGN_00062	7.76e-279	-	-	-	P	-	-	-	Voltage gated chloride channel
NLIIHIGN_00063	0.0	gshAB	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
NLIIHIGN_00064	1.01e-43	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
NLIIHIGN_00065	1.14e-300	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
NLIIHIGN_00066	4.47e-44	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NLIIHIGN_00067	9.64e-141	rfbC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
NLIIHIGN_00068	2.77e-51	axe	-	-	K	ko:K21498	-	ko00000,ko02048	Helix-turn-helix XRE-family like proteins
NLIIHIGN_00069	1.29e-59	-	-	-	S	ko:K07334	-	ko00000,ko02048	RelE-like toxin of type II toxin-antitoxin system HigB
NLIIHIGN_00070	1.57e-66	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
NLIIHIGN_00072	2.07e-209	-	-	-	L	ko:K07448	-	ko00000,ko02048	restriction endonuclease
NLIIHIGN_00082	1.02e-196	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
NLIIHIGN_00083	9.59e-216	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
NLIIHIGN_00084	0.0	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00085	1.89e-171	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00086	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
NLIIHIGN_00087	2.65e-214	-	-	-	G	-	-	-	Phosphotransferase enzyme family
NLIIHIGN_00088	2.19e-100	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
NLIIHIGN_00089	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NLIIHIGN_00090	2.38e-72	-	-	-	-	-	-	-	-
NLIIHIGN_00091	1.05e-168	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
NLIIHIGN_00092	2.15e-234	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
NLIIHIGN_00093	3.36e-77	-	-	-	-	-	-	-	-
NLIIHIGN_00095	3.37e-222	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
NLIIHIGN_00096	3.16e-258	-	-	-	C	-	-	-	Belongs to the LDH2 MDH2 oxidoreductase family
NLIIHIGN_00097	0.0	pepD3	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
NLIIHIGN_00098	1.21e-30	-	-	-	K	-	-	-	Peptidase S24-like
NLIIHIGN_00099	2.6e-14	-	-	-	K	-	-	-	Peptidase S24-like
NLIIHIGN_00100	5.09e-107	-	-	-	-	-	-	-	-
NLIIHIGN_00101	2.44e-99	-	-	-	-	-	-	-	-
NLIIHIGN_00102	4.29e-18	-	-	-	-	-	-	-	-
NLIIHIGN_00103	1.7e-182	-	-	-	-	-	-	-	-
NLIIHIGN_00104	4.55e-288	int7	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_00105	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
NLIIHIGN_00106	3.81e-274	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
NLIIHIGN_00107	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
NLIIHIGN_00108	2.83e-118	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NLIIHIGN_00109	1.37e-248	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
NLIIHIGN_00110	2.54e-84	-	-	-	-	-	-	-	-
NLIIHIGN_00111	4.14e-230	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
NLIIHIGN_00112	1.48e-216	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NLIIHIGN_00113	1.38e-77	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NLIIHIGN_00114	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NLIIHIGN_00115	1.96e-65	ylxQ	-	-	J	-	-	-	ribosomal protein
NLIIHIGN_00116	2.42e-59	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
NLIIHIGN_00117	3.54e-276	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
NLIIHIGN_00118	1.1e-108	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
NLIIHIGN_00119	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NLIIHIGN_00120	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
NLIIHIGN_00121	9.87e-300	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
NLIIHIGN_00122	4.1e-178	cdsA	2.7.7.41	-	I	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
NLIIHIGN_00123	6.92e-184	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NLIIHIGN_00125	7.41e-180	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
NLIIHIGN_00126	1.26e-55	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
NLIIHIGN_00129	2.75e-215	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
NLIIHIGN_00130	1.78e-204	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to
NLIIHIGN_00131	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
NLIIHIGN_00132	5.22e-176	XK27_05695	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00133	7.79e-236	-	-	-	T	-	-	-	Histidine kinase-like ATPases
NLIIHIGN_00134	6.91e-164	XK27_10500	-	-	K	-	-	-	response regulator
NLIIHIGN_00135	1.4e-152	yvgN	-	-	S	-	-	-	Aldo keto reductase
NLIIHIGN_00136	5.87e-177	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
NLIIHIGN_00137	8.19e-108	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
NLIIHIGN_00138	2.72e-262	-	-	-	-	-	-	-	-
NLIIHIGN_00139	4.33e-69	-	-	-	-	-	-	-	-
NLIIHIGN_00140	1.21e-48	-	-	-	-	-	-	-	-
NLIIHIGN_00141	1.65e-122	-	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
NLIIHIGN_00142	4.87e-190	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
NLIIHIGN_00143	7.24e-239	celE3	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
NLIIHIGN_00144	3.09e-289	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NLIIHIGN_00145	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
NLIIHIGN_00146	2.92e-233	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
NLIIHIGN_00147	1.09e-134	apl	3.1.3.1	-	S	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	SNARE associated Golgi protein
NLIIHIGN_00148	5.61e-292	gltT	-	-	U	ko:K03309,ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
NLIIHIGN_00149	3.83e-104	-	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	AsnC family
NLIIHIGN_00150	2.71e-103	usp5	-	-	T	-	-	-	universal stress protein
NLIIHIGN_00151	5.13e-46	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
NLIIHIGN_00152	1.36e-99	ltrA	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
NLIIHIGN_00153	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
NLIIHIGN_00154	4.48e-55	-	-	-	-	-	-	-	-
NLIIHIGN_00155	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NLIIHIGN_00156	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NLIIHIGN_00157	3.75e-246	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	Transporter, major facilitator family protein
NLIIHIGN_00158	2.59e-97	-	-	-	S	ko:K04750	-	ko00000	3-demethylubiquinone-9 3-methyltransferase
NLIIHIGN_00159	1.15e-109	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
NLIIHIGN_00160	4.1e-308	yhdP	-	-	S	-	-	-	Transporter associated domain
NLIIHIGN_00161	2.81e-198	-	-	-	V	-	-	-	(ABC) transporter
NLIIHIGN_00162	1.9e-115	-	-	-	GM	-	-	-	epimerase
NLIIHIGN_00163	1.51e-117	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
NLIIHIGN_00164	8.16e-103	yybA	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_00165	7.74e-173	XK27_07210	-	-	S	-	-	-	B3 4 domain
NLIIHIGN_00166	2.39e-239	XK27_12525	-	-	S	-	-	-	AI-2E family transporter
NLIIHIGN_00167	9.91e-204	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
NLIIHIGN_00168	7.57e-206	-	-	-	-	-	-	-	-
NLIIHIGN_00169	1.32e-52	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_00170	2e-136	-	-	-	L	-	-	-	Helix-turn-helix domain
NLIIHIGN_00171	1.65e-100	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
NLIIHIGN_00172	2.29e-130	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
NLIIHIGN_00173	9.83e-316	lmrB	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Belongs to the major facilitator superfamily
NLIIHIGN_00174	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
NLIIHIGN_00175	1.37e-144	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NLIIHIGN_00176	7.9e-214	-	-	-	O	-	-	-	Uncharacterized protein family (UPF0051)
NLIIHIGN_00177	6.73e-149	-	-	-	M	-	-	-	LysM domain protein
NLIIHIGN_00178	0.0	-	-	-	EP	-	-	-	Psort location Cytoplasmic, score
NLIIHIGN_00179	4.57e-137	-	-	-	M	-	-	-	LysM domain protein
NLIIHIGN_00180	2.83e-190	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
NLIIHIGN_00181	4.87e-299	-	1.3.1.1	-	E	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
NLIIHIGN_00182	2.29e-309	-	1.3.1.1	-	C	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	ko00000,ko00001,ko00002,ko01000	4Fe-4S dicluster domain
NLIIHIGN_00183	2.42e-201	yeaE	-	-	S	-	-	-	Aldo keto
NLIIHIGN_00184	4.63e-101	hsp	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
NLIIHIGN_00185	0.0	umuC	-	-	L	ko:K03502	-	ko00000,ko03400	impB/mucB/samB family C-terminal domain
NLIIHIGN_00186	7.91e-104	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
NLIIHIGN_00187	2.05e-110	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
NLIIHIGN_00188	7.03e-33	-	-	-	-	-	-	-	-
NLIIHIGN_00189	2.01e-134	-	-	-	V	-	-	-	VanZ like family
NLIIHIGN_00190	8.53e-304	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
NLIIHIGN_00191	1.25e-111	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
NLIIHIGN_00192	0.0	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_00193	7.96e-41	-	-	-	-	-	-	-	-
NLIIHIGN_00194	4.49e-130	tag1	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
NLIIHIGN_00195	6.66e-281	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NLIIHIGN_00196	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
NLIIHIGN_00197	8.74e-57	-	-	-	-	-	-	-	-
NLIIHIGN_00198	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
NLIIHIGN_00199	9.07e-199	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NLIIHIGN_00200	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
NLIIHIGN_00201	5.35e-113	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
NLIIHIGN_00202	9.46e-242	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NLIIHIGN_00203	3.06e-150	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
NLIIHIGN_00204	5.33e-147	-	-	-	-	-	-	-	-
NLIIHIGN_00205	2.63e-240	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
NLIIHIGN_00206	8.45e-210	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLIIHIGN_00207	1.52e-43	-	-	-	-	-	-	-	-
NLIIHIGN_00208	2.21e-155	XK27_07085	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
NLIIHIGN_00209	0.0	melA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
NLIIHIGN_00210	4.39e-244	galR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding protein-like domain
NLIIHIGN_00211	5.79e-214	scrK	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	ROK family
NLIIHIGN_00212	1.19e-229	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
NLIIHIGN_00213	6.23e-161	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	LrgB-like family
NLIIHIGN_00214	3.69e-87	lrgA	-	-	S	ko:K05338	ko02020,map02020	ko00000,ko00001,ko02000	LrgA family
NLIIHIGN_00215	2.9e-169	lytT	-	-	K	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator receiver
NLIIHIGN_00216	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	LytS YhcK-type transmembrane receptor domain protein
NLIIHIGN_00217	1.54e-191	-	-	-	O	-	-	-	Band 7 protein
NLIIHIGN_00218	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
NLIIHIGN_00219	1.7e-200	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
NLIIHIGN_00220	1.43e-51	-	-	-	S	-	-	-	Cytochrome B5
NLIIHIGN_00221	3.4e-146	nreC	-	-	K	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	PFAM regulatory protein LuxR
NLIIHIGN_00222	3.31e-206	-	-	-	K	ko:K20480	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix
NLIIHIGN_00223	3.96e-75	-	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
NLIIHIGN_00224	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
NLIIHIGN_00225	5.28e-105	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
NLIIHIGN_00226	3.86e-300	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NLIIHIGN_00227	4.96e-307	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
NLIIHIGN_00228	5.43e-185	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
NLIIHIGN_00229	9.89e-43	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA domain
NLIIHIGN_00230	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
NLIIHIGN_00231	0.0	menE	6.2.1.26	-	H	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
NLIIHIGN_00232	6.96e-201	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NLIIHIGN_00233	9.18e-83	yuxO	-	-	Q	-	-	-	Thioesterase superfamily
NLIIHIGN_00234	3.51e-142	yvrI	-	-	K	ko:K03091,ko:K03093	-	ko00000,ko03021	sigma factor activity
NLIIHIGN_00235	2.07e-263	-	-	-	G	-	-	-	Transporter, major facilitator family protein
NLIIHIGN_00236	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
NLIIHIGN_00237	1.81e-146	-	-	-	T	ko:K10716	-	ko00000,ko02000	Ion transport 2 domain protein
NLIIHIGN_00238	4.12e-227	rihA	-	-	F	ko:K01250	-	ko00000,ko01000	Inosine-uridine preferring nucleoside hydrolase
NLIIHIGN_00240	0.0	-	-	-	L	-	-	-	PLD-like domain
NLIIHIGN_00241	1.27e-82	mrr2	-	-	L	ko:K07448	-	ko00000,ko02048	restriction endonuclease
NLIIHIGN_00242	4.72e-134	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
NLIIHIGN_00243	2.45e-218	glpT	-	-	G	ko:K02445	-	ko00000,ko02000	Major Facilitator Superfamily
NLIIHIGN_00244	1.19e-47	glpT	-	-	G	ko:K02445	-	ko00000,ko02000	Major Facilitator Superfamily
NLIIHIGN_00245	1.83e-21	-	-	-	-	-	-	-	-
NLIIHIGN_00247	1.37e-218	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
NLIIHIGN_00248	6.97e-240	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
NLIIHIGN_00249	3.42e-209	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
NLIIHIGN_00250	9.18e-317	steT	-	-	E	ko:K03294	-	ko00000	amino acid
NLIIHIGN_00251	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
NLIIHIGN_00252	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
NLIIHIGN_00253	2.12e-19	-	-	-	-	-	-	-	-
NLIIHIGN_00254	3.57e-150	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
NLIIHIGN_00255	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
NLIIHIGN_00256	5.98e-116	ykhA	3.1.2.20	-	I	ko:K01073	-	ko00000,ko01000	Thioesterase superfamily
NLIIHIGN_00257	5.33e-211	-	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	PFAM extracellular solute-binding protein, family 3
NLIIHIGN_00258	9.41e-278	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
NLIIHIGN_00259	2.04e-223	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
NLIIHIGN_00260	1.94e-215	lutA	-	-	C	ko:K18928	-	ko00000	Cysteine-rich domain
NLIIHIGN_00261	0.0	lutB	-	-	C	ko:K18929	-	ko00000	4Fe-4S dicluster domain
NLIIHIGN_00262	4.49e-178	lutC	-	-	S	ko:K00782	-	ko00000	LUD domain
NLIIHIGN_00263	1.08e-215	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
NLIIHIGN_00264	5.93e-237	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
NLIIHIGN_00265	4.38e-205	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NLIIHIGN_00266	1.38e-226	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NLIIHIGN_00267	1.88e-68	yvlD	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
NLIIHIGN_00268	3.65e-67	-	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain protein
NLIIHIGN_00269	4.72e-240	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NLIIHIGN_00270	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
NLIIHIGN_00271	3.01e-125	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NLIIHIGN_00272	1.4e-163	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
NLIIHIGN_00273	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
NLIIHIGN_00274	1.4e-146	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
NLIIHIGN_00275	0.0	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_00276	3.07e-89	-	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_00277	1.81e-108	-	-	-	-	-	-	-	-
NLIIHIGN_00278	1.92e-238	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
NLIIHIGN_00279	0.0	lacS	-	-	G	ko:K11104,ko:K16209	-	ko00000,ko02000	Transporter
NLIIHIGN_00280	0.0	lacZ	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	-beta-galactosidase
NLIIHIGN_00281	8.36e-231	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
NLIIHIGN_00282	8.07e-204	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
NLIIHIGN_00283	3.86e-185	XK27_00940	3.5.1.9	-	S	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	ko00000,ko00001,ko00002,ko01000	Putative cyclase
NLIIHIGN_00284	1.1e-280	-	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
NLIIHIGN_00285	2.14e-166	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
NLIIHIGN_00286	6.04e-290	mdtG2	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
NLIIHIGN_00287	4.96e-215	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
NLIIHIGN_00288	2.48e-57	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NLIIHIGN_00289	1.49e-69	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
NLIIHIGN_00290	4.84e-233	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_00293	1.29e-156	sdhB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
NLIIHIGN_00294	4.78e-193	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
NLIIHIGN_00295	5.4e-135	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	Peroxiredoxin
NLIIHIGN_00296	0.0	-	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Thioredoxin domain
NLIIHIGN_00297	3.09e-248	tnp2	-	-	L	-	-	-	PFAM Transposase, IS204 IS1001 IS1096 IS1165
NLIIHIGN_00298	0.0	pepD4	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
NLIIHIGN_00299	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
NLIIHIGN_00300	1.89e-35	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
NLIIHIGN_00301	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NLIIHIGN_00302	3.88e-107	-	-	-	-	-	-	-	-
NLIIHIGN_00303	3.26e-48	-	-	-	-	-	-	-	-
NLIIHIGN_00304	3.91e-130	-	-	-	K	-	-	-	DNA-templated transcription, initiation
NLIIHIGN_00305	3.34e-38	-	-	-	-	-	-	-	-
NLIIHIGN_00306	4.91e-80	-	-	-	L	ko:K07491	-	ko00000	PFAM transposase IS200-family protein
NLIIHIGN_00307	2.56e-292	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_00308	6.91e-118	-	-	-	-	-	-	-	-
NLIIHIGN_00309	5.17e-86	-	-	-	K	-	-	-	Transcriptional regulator, HxlR family
NLIIHIGN_00310	1.92e-219	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
NLIIHIGN_00311	1.95e-191	epsB	-	-	M	-	-	-	biosynthesis protein
NLIIHIGN_00312	8.04e-158	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
NLIIHIGN_00313	1.03e-131	rfbP	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
NLIIHIGN_00314	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
NLIIHIGN_00315	1.39e-101	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
NLIIHIGN_00316	1.8e-249	adhP	1.1.1.1	-	C	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
NLIIHIGN_00317	7.53e-191	-	-	-	S	ko:K06889	-	ko00000	Hydrolases of the alpha beta superfamily
NLIIHIGN_00321	2.09e-24	-	-	-	L	-	-	-	Conserved phage C-terminus (Phg_2220_C)
NLIIHIGN_00323	1.31e-11	-	-	-	S	-	-	-	Helix-turn-helix domain
NLIIHIGN_00324	5.65e-14	-	-	-	K	-	-	-	PFAM helix-turn-helix domain protein
NLIIHIGN_00325	4.5e-61	sip	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_00331	7.78e-150	dgk2	-	-	F	-	-	-	deoxynucleoside kinase
NLIIHIGN_00332	0.0	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
NLIIHIGN_00333	8.71e-07	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
NLIIHIGN_00334	2.79e-153	-	-	-	I	-	-	-	phosphatase
NLIIHIGN_00335	2.59e-107	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
NLIIHIGN_00336	7.95e-171	-	-	-	S	-	-	-	Putative threonine/serine exporter
NLIIHIGN_00337	2.17e-43	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
NLIIHIGN_00338	2.32e-161	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
NLIIHIGN_00339	4.04e-212	-	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
NLIIHIGN_00340	3.11e-153	-	-	-	S	-	-	-	membrane
NLIIHIGN_00341	4.71e-142	-	-	-	S	-	-	-	VIT family
NLIIHIGN_00342	4.83e-108	-	-	-	T	-	-	-	Belongs to the universal stress protein A family
NLIIHIGN_00343	4.64e-172	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00344	9.45e-196	peb1A	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_00345	5.24e-143	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00346	3.65e-141	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00347	8.11e-282	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
NLIIHIGN_00348	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NLIIHIGN_00349	8.46e-77	-	-	-	-	-	-	-	-
NLIIHIGN_00350	5.33e-98	-	-	-	K	-	-	-	MerR HTH family regulatory protein
NLIIHIGN_00351	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
NLIIHIGN_00352	6.51e-161	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
NLIIHIGN_00353	3.34e-212	yjbO	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
NLIIHIGN_00355	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NLIIHIGN_00356	2.58e-254	-	-	-	L	-	-	-	Transposase
NLIIHIGN_00357	1.28e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
NLIIHIGN_00358	5.45e-153	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NLIIHIGN_00359	6.64e-139	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
NLIIHIGN_00360	3.61e-61	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
NLIIHIGN_00361	1.16e-203	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NLIIHIGN_00362	5.72e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NLIIHIGN_00363	4.36e-70	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NLIIHIGN_00364	9.81e-157	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NLIIHIGN_00365	1.96e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NLIIHIGN_00366	5.49e-38	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
NLIIHIGN_00367	1.1e-55	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NLIIHIGN_00368	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NLIIHIGN_00369	2.58e-65	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NLIIHIGN_00370	7.42e-125	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NLIIHIGN_00371	1.54e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NLIIHIGN_00372	2.6e-124	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NLIIHIGN_00373	5.03e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NLIIHIGN_00374	5.95e-112	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NLIIHIGN_00375	5.94e-34	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
NLIIHIGN_00376	6.05e-93	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
NLIIHIGN_00377	2.88e-306	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
NLIIHIGN_00378	4.52e-161	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
NLIIHIGN_00379	2.41e-45	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NLIIHIGN_00380	5.79e-21	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
NLIIHIGN_00381	1.54e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NLIIHIGN_00382	1.62e-83	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NLIIHIGN_00383	2.19e-220	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NLIIHIGN_00384	8.08e-83	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
NLIIHIGN_00385	2.21e-189	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NLIIHIGN_00386	2.6e-199	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NLIIHIGN_00387	5.82e-181	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NLIIHIGN_00388	1.23e-181	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
NLIIHIGN_00389	9.25e-103	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NLIIHIGN_00390	3.94e-85	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
NLIIHIGN_00391	1.56e-180	budC	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	reductase
NLIIHIGN_00392	5.09e-148	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
NLIIHIGN_00393	4.76e-131	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
NLIIHIGN_00394	3.24e-272	purK2	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NLIIHIGN_00395	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
NLIIHIGN_00396	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NLIIHIGN_00397	3.17e-260	camS	-	-	S	-	-	-	sex pheromone
NLIIHIGN_00398	1.36e-66	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NLIIHIGN_00399	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
NLIIHIGN_00400	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NLIIHIGN_00401	7.79e-237	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
NLIIHIGN_00402	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
NLIIHIGN_00403	1.79e-138	-	-	-	NU	-	-	-	mannosyl-glycoprotein
NLIIHIGN_00404	1.57e-190	-	-	-	S	-	-	-	Putative ABC-transporter type IV
NLIIHIGN_00405	0.0	-	-	-	S	-	-	-	ABC transporter, ATP-binding protein
NLIIHIGN_00408	1.15e-139	-	-	-	S	-	-	-	Protein of unknown function (DUF3278)
NLIIHIGN_00409	3.01e-19	-	-	-	L	ko:K07473	-	ko00000,ko02048	RelB antitoxin
NLIIHIGN_00411	6.32e-171	-	-	-	M	-	-	-	PFAM NLP P60 protein
NLIIHIGN_00412	7.76e-234	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
NLIIHIGN_00413	1.18e-196	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
NLIIHIGN_00414	3.96e-177	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00415	6.27e-125	-	-	-	P	-	-	-	Cadmium resistance transporter
NLIIHIGN_00416	1.14e-74	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
NLIIHIGN_00417	1.94e-305	mepA	-	-	V	ko:K18908	-	ko00000,ko00002,ko01504,ko02000	MATE efflux family protein
NLIIHIGN_00418	6.46e-74	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
NLIIHIGN_00419	3.78e-169	yceF	-	-	P	ko:K05794	-	ko00000	membrane
NLIIHIGN_00420	4.92e-213	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
NLIIHIGN_00421	2.63e-212	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
NLIIHIGN_00422	0.0	pepD1	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
NLIIHIGN_00423	2.77e-306	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
NLIIHIGN_00424	0.0	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
NLIIHIGN_00425	0.0	-	-	-	S	-	-	-	C4-dicarboxylate anaerobic carrier
NLIIHIGN_00426	9.13e-160	pgm3	-	-	G	-	-	-	phosphoglycerate mutase family
NLIIHIGN_00427	1.77e-56	-	-	-	-	-	-	-	-
NLIIHIGN_00428	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
NLIIHIGN_00429	5.74e-264	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	dehydrogenase
NLIIHIGN_00430	9.25e-190	-	-	-	S	-	-	-	Alpha beta hydrolase
NLIIHIGN_00431	1.02e-279	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
NLIIHIGN_00432	5.74e-62	-	-	-	-	-	-	-	-
NLIIHIGN_00434	5.09e-162	-	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
NLIIHIGN_00435	1.89e-171	-	-	-	IQ	-	-	-	dehydrogenase reductase
NLIIHIGN_00436	2.33e-51	-	-	-	-	-	-	-	-
NLIIHIGN_00437	8.78e-29	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
NLIIHIGN_00438	7.95e-102	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
NLIIHIGN_00439	2.3e-52	-	-	-	S	-	-	-	Cytochrome b5-like Heme/Steroid binding domain
NLIIHIGN_00440	0.0	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
NLIIHIGN_00441	5.64e-232	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NLIIHIGN_00443	2.5e-132	-	-	-	S	ko:K07002	-	ko00000	Serine hydrolase
NLIIHIGN_00444	1.26e-82	psiE	-	-	S	ko:K13256	-	ko00000	Phosphate-starvation-inducible E
NLIIHIGN_00445	6.12e-182	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NLIIHIGN_00447	3.04e-233	ydhF	-	-	S	-	-	-	Aldo keto reductase
NLIIHIGN_00448	3.6e-107	-	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	PAP2 superfamily
NLIIHIGN_00449	0.0	-	-	-	L	-	-	-	Helicase C-terminal domain protein
NLIIHIGN_00451	0.0	-	1.8.1.7	-	C	ko:K00383,ko:K21739	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Pyridine nucleotide-disulfide oxidoreductase
NLIIHIGN_00452	2.84e-73	-	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
NLIIHIGN_00453	9.01e-164	-	-	-	-	-	-	-	-
NLIIHIGN_00454	2.88e-165	XK27_08875	-	-	O	-	-	-	PFAM peptidase M10A and M12B, matrixin and adamalysin
NLIIHIGN_00455	0.0	cadA	-	-	P	-	-	-	P-type ATPase
NLIIHIGN_00456	6.49e-288	-	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Metalloenzyme superfamily
NLIIHIGN_00457	4.44e-11	-	-	-	-	-	-	-	-
NLIIHIGN_00458	9.51e-217	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_00459	2.6e-197	-	-	-	GM	-	-	-	NAD(P)H-binding
NLIIHIGN_00460	1.11e-96	ywnA	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_00461	5.3e-209	proWY	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, substrate-binding protein, QAT family
NLIIHIGN_00462	2.35e-139	proWZ	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00463	4.13e-180	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00464	1.96e-138	-	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, permease protein
NLIIHIGN_00465	1.05e-101	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
NLIIHIGN_00466	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
NLIIHIGN_00467	6.12e-279	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
NLIIHIGN_00468	5.25e-140	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00469	2.34e-242	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NLIIHIGN_00470	6.34e-193	metQ	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
NLIIHIGN_00471	5.14e-217	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
NLIIHIGN_00472	1.63e-278	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	transporter
NLIIHIGN_00473	9.57e-52	-	1.3.5.4	-	S	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FMN binding
NLIIHIGN_00474	8.11e-152	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NLIIHIGN_00475	0.0	ctrA	-	-	E	ko:K03294	-	ko00000	amino acid
NLIIHIGN_00476	0.0	gabT	2.6.1.19, 5.1.1.21	-	E	ko:K00823,ko:K20708	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NLIIHIGN_00478	1.57e-260	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
NLIIHIGN_00479	0.0	-	-	-	L	-	-	-	DNA helicase
NLIIHIGN_00480	1.17e-105	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Belongs to the NDK family
NLIIHIGN_00481	6.68e-238	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Belongs to the N(4) N(6)-methyltransferase family
NLIIHIGN_00482	5.54e-243	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
NLIIHIGN_00483	2.53e-214	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
NLIIHIGN_00484	1.98e-297	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
NLIIHIGN_00485	1.33e-228	-	-	-	-	-	-	-	-
NLIIHIGN_00486	2.93e-168	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	SIR2 family
NLIIHIGN_00488	2.74e-207	yunF	-	-	F	-	-	-	Protein of unknown function DUF72
NLIIHIGN_00489	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLIIHIGN_00490	1.12e-198	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
NLIIHIGN_00491	1.04e-128	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NLIIHIGN_00492	3.58e-206	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
NLIIHIGN_00493	2.74e-50	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
NLIIHIGN_00494	1.71e-206	ispE	2.7.1.148	-	F	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NLIIHIGN_00495	8.21e-215	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
NLIIHIGN_00496	3.28e-156	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
NLIIHIGN_00497	5.02e-165	-	-	-	U	ko:K02075	-	ko00000,ko00002,ko02000	ABC 3 transport family
NLIIHIGN_00498	2.09e-190	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
NLIIHIGN_00499	4.57e-316	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NLIIHIGN_00500	4.12e-228	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NLIIHIGN_00501	8.69e-98	-	-	-	-	-	-	-	-
NLIIHIGN_00502	2.57e-72	isp	-	-	L	-	-	-	Transposase
NLIIHIGN_00503	3.55e-214	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
NLIIHIGN_00504	0.0	-	-	-	D	-	-	-	Domain of Unknown Function (DUF1542)
NLIIHIGN_00505	2.84e-27	-	-	-	D	-	-	-	Domain of Unknown Function (DUF1542)
NLIIHIGN_00506	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
NLIIHIGN_00507	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
NLIIHIGN_00508	2.61e-204	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
NLIIHIGN_00509	4.93e-123	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
NLIIHIGN_00510	1.57e-111	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NLIIHIGN_00511	1.45e-152	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
NLIIHIGN_00512	1.59e-209	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
NLIIHIGN_00513	4.99e-178	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NLIIHIGN_00514	4.29e-162	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	sortase family
NLIIHIGN_00515	5.56e-214	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
NLIIHIGN_00516	2.02e-306	pts13C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
NLIIHIGN_00517	9.43e-56	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
NLIIHIGN_00518	6.72e-303	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NLIIHIGN_00519	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
NLIIHIGN_00520	2.44e-84	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
NLIIHIGN_00521	6.79e-91	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
NLIIHIGN_00522	3.43e-197	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	biotin lipoate A B protein ligase
NLIIHIGN_00523	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	HD domain protein
NLIIHIGN_00524	1.14e-190	yidA	-	-	S	-	-	-	hydrolase
NLIIHIGN_00525	1.38e-155	csrR	-	-	K	-	-	-	response regulator
NLIIHIGN_00526	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
NLIIHIGN_00527	0.0	potE	-	-	E	-	-	-	Amino Acid
NLIIHIGN_00528	1.06e-297	-	-	-	V	-	-	-	MatE
NLIIHIGN_00529	5.74e-94	def2	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins
NLIIHIGN_00530	9.55e-216	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NLIIHIGN_00531	1.07e-61	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
NLIIHIGN_00532	9.44e-187	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NLIIHIGN_00533	3.75e-119	XK27_09705	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
NLIIHIGN_00534	6.77e-77	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
NLIIHIGN_00535	2.47e-250	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NLIIHIGN_00536	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NLIIHIGN_00537	2.51e-150	-	-	-	M	-	-	-	PFAM NLP P60 protein
NLIIHIGN_00538	2.06e-152	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
NLIIHIGN_00539	6.08e-102	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
NLIIHIGN_00540	4.64e-92	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
NLIIHIGN_00541	0.0	-	-	-	S	-	-	-	membrane
NLIIHIGN_00542	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
NLIIHIGN_00543	1.53e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
NLIIHIGN_00544	1.61e-130	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NLIIHIGN_00545	2.39e-147	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
NLIIHIGN_00546	7.07e-48	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
NLIIHIGN_00547	2.51e-235	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
NLIIHIGN_00548	2.67e-88	yqhL	-	-	P	-	-	-	Rhodanese-like protein
NLIIHIGN_00549	1.18e-30	-	-	-	S	-	-	-	Protein of unknown function (DUF3042)
NLIIHIGN_00550	1.06e-228	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NLIIHIGN_00551	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
NLIIHIGN_00552	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NLIIHIGN_00553	1.31e-286	araT	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
NLIIHIGN_00554	1.28e-18	-	-	-	-	-	-	-	-
NLIIHIGN_00555	5.06e-199	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
NLIIHIGN_00559	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
NLIIHIGN_00560	2.01e-206	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
NLIIHIGN_00563	1.39e-148	-	-	-	-	-	-	-	-
NLIIHIGN_00564	0.0	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_00565	0.0	-	-	-	P	ko:K07085	-	ko00000	Predicted Permease Membrane Region
NLIIHIGN_00566	5.9e-170	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
NLIIHIGN_00567	3.54e-165	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
NLIIHIGN_00568	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NLIIHIGN_00569	5.27e-197	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
NLIIHIGN_00570	0.0	tex	-	-	K	ko:K06959	-	ko00000	Tex-like protein N-terminal domain protein
NLIIHIGN_00571	2e-112	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
NLIIHIGN_00573	0.0	lacL	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
NLIIHIGN_00574	5.72e-239	lacM	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase
NLIIHIGN_00575	0.0	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
NLIIHIGN_00576	3.04e-172	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NLIIHIGN_00577	1.27e-215	-	-	-	I	-	-	-	alpha/beta hydrolase fold
NLIIHIGN_00578	4.46e-276	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
NLIIHIGN_00579	3.36e-154	tcyB	-	-	E	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_00580	1.75e-173	-	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00581	3.01e-181	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
NLIIHIGN_00582	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
NLIIHIGN_00583	2.5e-162	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NLIIHIGN_00584	2.74e-65	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
NLIIHIGN_00585	1.02e-130	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTP diphosphatase
NLIIHIGN_00586	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NLIIHIGN_00587	4.91e-264	yacL	-	-	S	-	-	-	domain protein
NLIIHIGN_00588	2.21e-177	-	-	-	IQ	-	-	-	KR domain
NLIIHIGN_00589	1.1e-232	iunH1	3.2.2.1	-	F	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	nucleoside hydrolase
NLIIHIGN_00590	7.5e-237	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
NLIIHIGN_00591	7.79e-164	-	-	-	L	ko:K07497	-	ko00000	hmm pf00665
NLIIHIGN_00592	2.59e-77	-	-	-	L	-	-	-	Helix-turn-helix domain
NLIIHIGN_00593	3.33e-33	-	-	-	L	-	-	-	Helix-turn-helix domain
NLIIHIGN_00594	1.24e-37	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
NLIIHIGN_00595	4.01e-153	-	-	-	S	-	-	-	HAD hydrolase, family IA, variant
NLIIHIGN_00596	0.0	yagE	-	-	E	-	-	-	amino acid
NLIIHIGN_00597	2.93e-112	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
NLIIHIGN_00598	0.0	atp2C1	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
NLIIHIGN_00599	1.23e-225	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
NLIIHIGN_00600	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
NLIIHIGN_00601	7.22e-262	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
NLIIHIGN_00602	2.49e-187	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00603	7.65e-184	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00604	1.21e-266	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_00605	4.84e-293	-	-	-	-	-	-	-	-
NLIIHIGN_00606	0.0	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
NLIIHIGN_00607	1.46e-96	-	-	-	F	-	-	-	Nudix hydrolase
NLIIHIGN_00608	9.27e-133	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase
NLIIHIGN_00609	1.27e-108	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
NLIIHIGN_00610	8.66e-37	-	3.2.1.14	GH18	-	ko:K01183	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	-
NLIIHIGN_00611	1.98e-194	-	-	-	-	-	-	-	-
NLIIHIGN_00612	5.87e-51	pspC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	positive regulation of macromolecule biosynthetic process
NLIIHIGN_00613	1.76e-122	-	-	-	K	-	-	-	Transcriptional regulator (TetR family)
NLIIHIGN_00614	0.0	yhgE	-	-	V	ko:K01421	-	ko00000	domain protein
NLIIHIGN_00615	8.76e-300	isp	-	-	L	-	-	-	Transposase
NLIIHIGN_00617	2.47e-172	-	-	-	M	-	-	-	Prophage endopeptidase tail
NLIIHIGN_00618	1.7e-105	-	-	-	S	-	-	-	Phage tail protein
NLIIHIGN_00619	1.79e-310	-	-	-	L	-	-	-	Phage tail tape measure protein TP901
NLIIHIGN_00621	1.31e-101	-	-	-	S	-	-	-	Phage tail tube protein
NLIIHIGN_00623	1.19e-42	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
NLIIHIGN_00625	8.72e-63	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
NLIIHIGN_00626	2.83e-248	-	-	-	S	-	-	-	Phage capsid family
NLIIHIGN_00627	6.85e-148	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S14 family
NLIIHIGN_00628	8.33e-258	-	-	-	S	-	-	-	Phage portal protein
NLIIHIGN_00629	0.0	terL	-	-	S	-	-	-	overlaps another CDS with the same product name
NLIIHIGN_00630	1.05e-85	-	-	-	L	-	-	-	Phage terminase, small subunit
NLIIHIGN_00631	3.06e-92	-	-	-	L	-	-	-	HNH nucleases
NLIIHIGN_00643	2.04e-19	-	-	-	-	-	-	-	-
NLIIHIGN_00644	0.000447	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
NLIIHIGN_00646	1.18e-76	-	-	-	S	-	-	-	VRR_NUC
NLIIHIGN_00648	2.38e-291	-	-	-	S	ko:K06919	-	ko00000	Virulence-associated protein E
NLIIHIGN_00649	3.66e-182	-	-	-	S	-	-	-	Bifunctional DNA primase/polymerase, N-terminal
NLIIHIGN_00650	2.84e-120	-	-	-	-	-	-	-	-
NLIIHIGN_00651	1.5e-181	-	-	-	L	-	-	-	AAA domain
NLIIHIGN_00652	0.0	-	-	-	L	-	-	-	Helicase C-terminal domain protein
NLIIHIGN_00653	2.78e-103	-	-	-	S	-	-	-	Siphovirus Gp157
NLIIHIGN_00656	2.66e-40	-	-	-	-	-	-	-	-
NLIIHIGN_00658	2.63e-40	-	-	-	-	-	-	-	-
NLIIHIGN_00662	1.11e-123	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
NLIIHIGN_00663	5.98e-206	-	-	-	S	-	-	-	Alpha beta hydrolase
NLIIHIGN_00664	9.18e-206	gspA	-	-	M	-	-	-	family 8
NLIIHIGN_00665	7.48e-155	yagB	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
NLIIHIGN_00666	7.18e-126	-	-	-	-	-	-	-	-
NLIIHIGN_00667	1.2e-206	-	-	-	S	-	-	-	EDD domain protein, DegV family
NLIIHIGN_00668	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
NLIIHIGN_00669	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
NLIIHIGN_00670	5.52e-265	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarA family
NLIIHIGN_00671	7.11e-225	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
NLIIHIGN_00672	8.85e-97	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NLIIHIGN_00673	2.58e-85	esbA	-	-	S	-	-	-	Family of unknown function (DUF5322)
NLIIHIGN_00674	7.66e-92	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HI
NLIIHIGN_00675	1.2e-282	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
NLIIHIGN_00676	6.11e-111	-	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
NLIIHIGN_00677	6.82e-74	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
NLIIHIGN_00678	1.17e-135	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
NLIIHIGN_00679	1.21e-153	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
NLIIHIGN_00680	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
NLIIHIGN_00681	2.42e-208	-	-	-	EG	-	-	-	EamA-like transporter family
NLIIHIGN_00682	5e-161	dnaD	-	-	L	ko:K02086	-	ko00000	DnaD domain protein
NLIIHIGN_00683	1.15e-115	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
NLIIHIGN_00684	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
NLIIHIGN_00685	1.09e-221	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
NLIIHIGN_00686	1.74e-226	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
NLIIHIGN_00687	4.11e-274	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
NLIIHIGN_00688	1.31e-247	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
NLIIHIGN_00689	8.22e-122	-	-	-	S	ko:K08996	-	ko00000	Protein of unknown function (DUF1440)
NLIIHIGN_00690	2.82e-233	-	-	-	G	-	-	-	Peptidase_C39 like family
NLIIHIGN_00691	6.98e-40	-	-	-	-	-	-	-	-
NLIIHIGN_00692	0.0	ganB	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
NLIIHIGN_00693	4.3e-279	glf	5.4.99.9	-	M	ko:K01854	ko00052,ko00520,map00052,map00520	ko00000,ko00001,ko01000	UDP-galactopyranose mutase
NLIIHIGN_00694	8.02e-271	cps1C	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
NLIIHIGN_00695	1.22e-93	-	-	GT2	M	ko:K12997	-	ko00000,ko01000,ko01003,ko01005	Glycosyl transferase family 2
NLIIHIGN_00696	2.56e-140	-	-	-	S	-	-	-	Glycosyltransferase like family 2
NLIIHIGN_00697	1.58e-124	-	-	-	M	-	-	-	Glycosyltransferase like family 2
NLIIHIGN_00698	4.63e-119	cps3F	-	-	-	-	-	-	-
NLIIHIGN_00699	9.95e-58	-	-	-	M	-	-	-	biosynthesis protein
NLIIHIGN_00700	1.37e-95	-	-	-	M	-	-	-	Domain of unknown function (DUF4422)
NLIIHIGN_00701	1.36e-83	cps3I	-	-	G	-	-	-	Acyltransferase family
NLIIHIGN_00702	1.39e-142	-	-	-	-	-	-	-	-
NLIIHIGN_00704	1.6e-36	-	-	-	-	-	-	-	-
NLIIHIGN_00705	3e-111	-	-	-	-	-	-	-	-
NLIIHIGN_00706	3.29e-183	-	-	-	M	-	-	-	Glycosyl transferase family 2
NLIIHIGN_00707	0.0	-	-	CBM50	NU	ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NLIIHIGN_00709	3.95e-183	npp	-	-	S	-	-	-	type I phosphodiesterase nucleotide pyrophosphatase
NLIIHIGN_00710	2.99e-289	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	Vacuole effluxer Atg22 like
NLIIHIGN_00712	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NLIIHIGN_00713	2.09e-86	-	-	-	-	-	-	-	-
NLIIHIGN_00714	0.0	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
NLIIHIGN_00715	9.96e-244	-	-	-	E	-	-	-	Zinc-binding dehydrogenase
NLIIHIGN_00716	5.75e-117	-	-	-	K	-	-	-	transcriptional regulator (TetR family)
NLIIHIGN_00717	2.5e-236	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
NLIIHIGN_00718	1.05e-155	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00719	0.0	yhcA	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00720	9.71e-50	-	-	-	-	-	-	-	-
NLIIHIGN_00721	1.36e-66	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
NLIIHIGN_00722	0.0	-	3.2.1.17	CBM50	NU	ko:K01185,ko:K02395,ko:K19223	-	ko00000,ko01000,ko01002,ko01011,ko02035	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NLIIHIGN_00723	7.96e-223	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	Transcriptional regulator, LacI family
NLIIHIGN_00724	2.6e-33	-	-	-	-	-	-	-	-
NLIIHIGN_00725	1.03e-146	-	-	-	-	-	-	-	-
NLIIHIGN_00726	5.21e-275	yttB	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_00727	1.61e-310	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
NLIIHIGN_00728	1.04e-114	-	-	-	-	-	-	-	-
NLIIHIGN_00729	2.13e-142	nnrE	5.1.99.6	-	H	ko:K17759	-	ko00000,ko01000	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
NLIIHIGN_00730	1.25e-54	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
NLIIHIGN_00731	6.1e-100	cylB	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
NLIIHIGN_00732	4.34e-200	-	-	-	V	ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_00733	2.48e-58	-	-	-	-	-	-	-	-
NLIIHIGN_00734	7e-121	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_00735	6.12e-71	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_00736	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	E1-E2 ATPase
NLIIHIGN_00737	1.35e-46	-	-	-	C	-	-	-	Heavy-metal-associated domain
NLIIHIGN_00738	2.13e-122	dpsB	-	-	P	-	-	-	Belongs to the Dps family
NLIIHIGN_00739	3.39e-146	fnr	-	-	K	ko:K21562	-	ko00000,ko03000	Transcriptional regulator, Crp Fnr family
NLIIHIGN_00740	4.84e-21	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
NLIIHIGN_00741	4.43e-13	-	-	-	L	-	-	-	Winged helix-turn helix
NLIIHIGN_00743	3.62e-268	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
NLIIHIGN_00744	0.0	-	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	pyridine nucleotide-disulfide oxidoreductase
NLIIHIGN_00745	2.89e-110	yvbK	-	-	K	-	-	-	GNAT family
NLIIHIGN_00746	5.22e-120	-	-	-	-	-	-	-	-
NLIIHIGN_00747	3.87e-161	pnb	-	-	C	-	-	-	nitroreductase
NLIIHIGN_00748	4.43e-65	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Methyltransferase
NLIIHIGN_00749	2.35e-165	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_00750	4.43e-100	XK27_00915	-	-	C	-	-	-	Luciferase-like monooxygenase
NLIIHIGN_00751	1.22e-218	-	3.2.1.96, 3.5.1.28	GH73	M	ko:K01227,ko:K01447,ko:K13714,ko:K13731	ko00511,ko05100,map00511,map05100	ko00000,ko00001,ko01000	N-acetylmuramoyl-L-alanine amidase
NLIIHIGN_00752	4.56e-99	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
NLIIHIGN_00753	2.57e-103	-	-	-	K	-	-	-	LytTr DNA-binding domain
NLIIHIGN_00754	1.41e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
NLIIHIGN_00755	7.31e-27	-	-	-	-	-	-	-	-
NLIIHIGN_00756	1.59e-153	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
NLIIHIGN_00757	3.32e-107	yjcF	3.5.4.33, 4.4.1.8	-	K	ko:K02348,ko:K07000,ko:K11991,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007,ko03016	protein acetylation
NLIIHIGN_00758	1.32e-255	-	-	-	S	-	-	-	Protein of unknown function (DUF3114)
NLIIHIGN_00759	0.0	gshA	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
NLIIHIGN_00760	2.64e-213	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
NLIIHIGN_00761	2.85e-138	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
NLIIHIGN_00762	2.28e-53	-	-	-	H	-	-	-	RibD C-terminal domain
NLIIHIGN_00763	1.15e-26	-	-	-	S	-	-	-	PemK-like, MazF-like toxin of type II toxin-antitoxin system
NLIIHIGN_00764	3.43e-27	-	-	-	L	-	-	-	Addiction module antitoxin, RelB DinJ family
NLIIHIGN_00765	6.53e-118	-	-	-	J	ko:K19055	-	ko00000,ko01000,ko03016	Aminoacyl-tRNA editing domain
NLIIHIGN_00766	9.8e-75	-	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
NLIIHIGN_00767	5.85e-254	flp	-	-	V	-	-	-	Beta-lactamase
NLIIHIGN_00768	2.6e-124	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
NLIIHIGN_00769	2.81e-158	-	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
NLIIHIGN_00770	4.91e-156	-	-	-	S	-	-	-	GyrI-like small molecule binding domain
NLIIHIGN_00772	3.18e-160	-	-	-	S	-	-	-	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
NLIIHIGN_00773	1.58e-66	azlD	-	-	E	-	-	-	Branched-chain amino acid transport
NLIIHIGN_00774	5.61e-156	azlC	-	-	E	-	-	-	azaleucine resistance protein AzlC
NLIIHIGN_00775	0.0	-	-	-	K	-	-	-	Aminotransferase class I and II
NLIIHIGN_00776	0.0	-	-	-	S	-	-	-	amidohydrolase
NLIIHIGN_00777	1.86e-212	-	-	-	S	-	-	-	reductase
NLIIHIGN_00778	2.55e-120	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase, GNAT family
NLIIHIGN_00779	2.44e-147	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
NLIIHIGN_00780	1.81e-315	yxbA	6.3.1.12	-	S	ko:K17810	-	ko00000,ko01000	ATP-grasp enzyme
NLIIHIGN_00781	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NLIIHIGN_00782	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
NLIIHIGN_00783	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
NLIIHIGN_00784	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NLIIHIGN_00793	1.74e-201	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
NLIIHIGN_00794	1.39e-173	pi112	-	-	L	-	-	-	PDDEXK-like domain of unknown function (DUF3799)
NLIIHIGN_00795	5.9e-93	-	-	-	L	-	-	-	Replication initiation and membrane attachment
NLIIHIGN_00799	1.63e-53	-	-	-	S	-	-	-	ORF6C domain
NLIIHIGN_00800	2.16e-22	-	-	-	-	-	-	-	-
NLIIHIGN_00803	1.19e-97	-	-	-	-	-	-	-	-
NLIIHIGN_00806	2.6e-157	-	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	sulfate reduction
NLIIHIGN_00809	1.78e-151	-	-	-	K	-	-	-	Belongs to the N(4) N(6)-methyltransferase family
NLIIHIGN_00810	5.3e-63	-	-	-	L	-	-	-	transposase activity
NLIIHIGN_00811	1.04e-287	-	-	-	S	ko:K06909	-	ko00000	Phage terminase, large subunit
NLIIHIGN_00812	9.04e-68	-	-	-	L	-	-	-	HNH endonuclease
NLIIHIGN_00813	2.32e-18	-	-	-	S	ko:K06909	-	ko00000	Phage terminase, large subunit
NLIIHIGN_00814	0.0	-	-	-	S	-	-	-	Phage portal protein, SPP1 Gp6-like
NLIIHIGN_00815	1.27e-220	-	-	-	S	-	-	-	Phage Mu protein F like protein
NLIIHIGN_00816	5.09e-132	-	-	-	S	-	-	-	Domain of unknown function (DUF4355)
NLIIHIGN_00817	5.02e-255	gpG	-	-	-	-	-	-	-
NLIIHIGN_00818	1.88e-74	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
NLIIHIGN_00819	6.27e-67	-	-	-	-	-	-	-	-
NLIIHIGN_00820	2.65e-121	-	-	-	-	-	-	-	-
NLIIHIGN_00821	6.71e-93	-	-	-	-	-	-	-	-
NLIIHIGN_00822	1.22e-138	-	-	-	-	-	-	-	-
NLIIHIGN_00823	6e-111	-	-	-	S	-	-	-	Phage tail assembly chaperone protein, TAC
NLIIHIGN_00824	0.0	-	-	-	D	-	-	-	domain protein
NLIIHIGN_00825	4.86e-214	-	-	-	S	-	-	-	Phage tail protein
NLIIHIGN_00826	0.0	-	-	-	M	-	-	-	CHAP domain
NLIIHIGN_00833	1.05e-47	-	-	-	S	-	-	-	Bacteriophage holin family
NLIIHIGN_00834	4.34e-72	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
NLIIHIGN_00835	9.59e-233	-	-	-	M	-	-	-	hydrolase, family 25
NLIIHIGN_00837	5.82e-96	-	-	-	-	-	-	-	-
NLIIHIGN_00838	1.22e-74	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NLIIHIGN_00839	4.05e-124	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
NLIIHIGN_00840	1.17e-136	folE	2.7.6.3, 3.5.4.16	-	F	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase 1
NLIIHIGN_00841	5.72e-301	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
NLIIHIGN_00842	8.88e-138	folQ	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Ham1 family
NLIIHIGN_00843	5.66e-278	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	dihydropteroate synthase
NLIIHIGN_00844	4.61e-61	-	-	-	-	-	-	-	-
NLIIHIGN_00845	1.49e-54	-	-	-	-	-	-	-	-
NLIIHIGN_00847	4.93e-216	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
NLIIHIGN_00848	1.51e-194	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
NLIIHIGN_00849	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
NLIIHIGN_00850	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
NLIIHIGN_00851	3.9e-79	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
NLIIHIGN_00852	3.37e-294	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	Ser Thr phosphatase family protein
NLIIHIGN_00853	0.0	yhaN	-	-	L	-	-	-	AAA domain
NLIIHIGN_00854	1e-176	prsA	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
NLIIHIGN_00856	1.49e-102	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	histidine triad
NLIIHIGN_00857	1.39e-177	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_00858	4.88e-281	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
NLIIHIGN_00859	4.53e-158	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
NLIIHIGN_00860	2.82e-34	-	-	-	S	-	-	-	YSIRK type signal peptide
NLIIHIGN_00861	3.3e-174	-	-	-	S	-	-	-	YSIRK type signal peptide
NLIIHIGN_00862	0.0	-	-	-	A	ko:K12092	ko05120,map05120	ko00000,ko00001,ko00002,ko02044	chlorophyll binding
NLIIHIGN_00863	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
NLIIHIGN_00864	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
NLIIHIGN_00865	0.0	frdA	1.3.5.4	-	C	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	ko00000,ko00001,ko00002,ko01000	FAD binding domain
NLIIHIGN_00866	1.85e-163	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
NLIIHIGN_00867	1.01e-214	citP	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
NLIIHIGN_00868	2.38e-155	citR	-	-	K	-	-	-	sugar-binding domain protein
NLIIHIGN_00869	3.46e-225	mae	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme, NAD binding domain
NLIIHIGN_00870	8.06e-189	citC	6.2.1.22	-	H	ko:K01910	ko02020,map02020	ko00000,ko00001,ko01000	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NLIIHIGN_00871	6.04e-55	citD	-	-	C	ko:K01646	ko02020,map02020	ko00000,ko00001	Covalent carrier of the coenzyme of citrate lyase
NLIIHIGN_00872	3.29e-204	citE	4.1.3.34	-	G	ko:K01644	ko02020,map02020	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
NLIIHIGN_00873	0.0	citF	2.8.3.10	-	H	ko:K01643	ko02020,map02020	ko00000,ko00001,ko01000	Citrate (pro-3S)-lyase alpha chain
NLIIHIGN_00874	1.56e-193	citG	2.4.2.52	-	H	ko:K05966	ko02020,map02020	ko00000,ko00001,ko01000	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
NLIIHIGN_00875	1.03e-142	-	-	-	I	-	-	-	Alpha/beta hydrolase family
NLIIHIGN_00876	7.21e-205	-	-	-	K	-	-	-	LysR family
NLIIHIGN_00877	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
NLIIHIGN_00878	7.76e-152	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil-DNA glycosylase
NLIIHIGN_00879	0.0	qacA	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_00880	6.72e-242	-	-	-	I	-	-	-	Alpha beta
NLIIHIGN_00881	4.55e-121	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
NLIIHIGN_00882	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NLIIHIGN_00883	5.23e-125	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
NLIIHIGN_00884	0.0	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
NLIIHIGN_00885	5.75e-103	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding
NLIIHIGN_00886	4.31e-76	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
NLIIHIGN_00887	1.01e-52	yabO	-	-	J	-	-	-	S4 domain protein
NLIIHIGN_00888	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NLIIHIGN_00889	1.38e-132	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
NLIIHIGN_00890	8.08e-147	-	-	-	S	-	-	-	(CBS) domain
NLIIHIGN_00891	2.06e-188	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
NLIIHIGN_00892	9.6e-310	codA	3.5.4.1	-	F	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	ko00000,ko00001,ko01000	cytosine deaminase
NLIIHIGN_00893	0.0	-	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
NLIIHIGN_00894	1.3e-82	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
NLIIHIGN_00895	2.28e-271	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NLIIHIGN_00896	2.29e-81	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
NLIIHIGN_00897	2.63e-08	dltX	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
NLIIHIGN_00898	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NLIIHIGN_00899	1.91e-301	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
NLIIHIGN_00900	1e-47	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
NLIIHIGN_00901	0.0	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NLIIHIGN_00902	0.0	arcT	-	-	E	-	-	-	Dipeptidase
NLIIHIGN_00903	0.0	arcD	-	-	S	-	-	-	C4-dicarboxylate anaerobic carrier
NLIIHIGN_00904	1.56e-229	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Peroxidase
NLIIHIGN_00905	2.93e-216	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
NLIIHIGN_00906	1.83e-174	-	-	-	I	-	-	-	alpha/beta hydrolase fold
NLIIHIGN_00907	1.18e-229	-	-	-	S	-	-	-	Conserved hypothetical protein 698
NLIIHIGN_00908	8.7e-123	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
NLIIHIGN_00909	1.13e-217	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
NLIIHIGN_00910	4.46e-227	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
NLIIHIGN_00911	3.13e-292	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
NLIIHIGN_00912	3.62e-112	-	-	-	Q	-	-	-	Methyltransferase
NLIIHIGN_00913	3.26e-151	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	domain protein
NLIIHIGN_00914	7.89e-304	ktrB	-	-	P	ko:K03498	-	ko00000,ko02000	Potassium uptake protein
NLIIHIGN_00915	0.0	mycA	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
NLIIHIGN_00916	4.47e-178	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
NLIIHIGN_00917	2.52e-286	-	-	-	G	-	-	-	Glycosyl hydrolases family 8
NLIIHIGN_00918	3.15e-313	-	-	-	M	-	-	-	Glycosyl transferase
NLIIHIGN_00919	6.17e-202	-	-	-	-	-	-	-	-
NLIIHIGN_00920	1.48e-247	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
NLIIHIGN_00921	5.83e-225	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
NLIIHIGN_00922	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NLIIHIGN_00923	0.0	ppx3	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
NLIIHIGN_00924	1.82e-177	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
NLIIHIGN_00925	5.48e-201	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NLIIHIGN_00926	3.71e-76	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
NLIIHIGN_00927	5.26e-235	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
NLIIHIGN_00928	2.83e-69	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
NLIIHIGN_00929	5.48e-150	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NLIIHIGN_00930	4.67e-52	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
NLIIHIGN_00931	4.92e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NLIIHIGN_00932	5.87e-62	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NLIIHIGN_00933	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NLIIHIGN_00934	6.21e-119	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
NLIIHIGN_00935	9.33e-48	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
NLIIHIGN_00936	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NLIIHIGN_00937	7.68e-254	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NLIIHIGN_00938	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
NLIIHIGN_00939	1.97e-231	-	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLIIHIGN_00940	6.08e-13	-	-	-	S	-	-	-	CsbD-like
NLIIHIGN_00941	1.9e-47	-	-	-	S	-	-	-	Transglycosylase associated protein
NLIIHIGN_00942	1.97e-295	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NLIIHIGN_00943	2.73e-161	pgm3	-	-	G	-	-	-	phosphoglycerate mutase
NLIIHIGN_00944	3.83e-147	-	-	-	S	ko:K03975	-	ko00000	SNARE associated Golgi protein
NLIIHIGN_00945	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
NLIIHIGN_00946	3.66e-309	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
NLIIHIGN_00947	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
NLIIHIGN_00948	2.73e-206	-	-	-	EG	-	-	-	EamA-like transporter family
NLIIHIGN_00949	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
NLIIHIGN_00950	2.39e-225	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
NLIIHIGN_00951	7.52e-283	-	-	-	S	ko:K07133	-	ko00000	cog cog1373
NLIIHIGN_00953	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
NLIIHIGN_00954	1.73e-287	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	Major Facilitator Superfamily
NLIIHIGN_00955	6.39e-201	-	-	-	J	-	-	-	Methyltransferase
NLIIHIGN_00956	2.82e-172	-	-	-	S	ko:K07009	-	ko00000	CobB/CobQ-like glutamine amidotransferase domain
NLIIHIGN_00957	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Mur ligase, middle domain
NLIIHIGN_00958	6.8e-140	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
NLIIHIGN_00959	1.73e-248	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NLIIHIGN_00960	7.63e-217	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
NLIIHIGN_00961	6.56e-252	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
NLIIHIGN_00962	9.39e-296	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NLIIHIGN_00963	6.68e-150	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NLIIHIGN_00964	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NLIIHIGN_00965	2.98e-249	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
NLIIHIGN_00966	4.22e-169	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
NLIIHIGN_00967	5.64e-294	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
NLIIHIGN_00968	4.63e-162	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
NLIIHIGN_00969	1.26e-29	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NLIIHIGN_00970	1.07e-95	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NLIIHIGN_00971	6.84e-121	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NLIIHIGN_00972	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NLIIHIGN_00973	1.3e-212	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NLIIHIGN_00974	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NLIIHIGN_00975	8.95e-90	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
NLIIHIGN_00976	6.11e-44	xylB	2.7.1.17, 2.7.1.53	-	G	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the FGGY kinase family
NLIIHIGN_00978	2.69e-36	-	-	-	-	-	-	-	-
NLIIHIGN_00979	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
NLIIHIGN_00980	2.09e-154	maa3	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
NLIIHIGN_00981	7.78e-200	-	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
NLIIHIGN_00982	0.0	yclK	-	-	T	-	-	-	Histidine kinase
NLIIHIGN_00983	2.06e-176	yclJ	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
NLIIHIGN_00985	2.2e-110	lytE	-	-	M	-	-	-	Lysin motif
NLIIHIGN_00986	4.88e-194	-	-	-	S	-	-	-	Cof-like hydrolase
NLIIHIGN_00987	7.53e-104	-	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_00988	0.0	oatA	-	-	I	-	-	-	Acyltransferase
NLIIHIGN_00989	5.17e-70	-	-	-	-	-	-	-	-
NLIIHIGN_00990	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
NLIIHIGN_00991	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NLIIHIGN_00992	1.99e-165	ybbR	-	-	S	-	-	-	YbbR-like protein
NLIIHIGN_00993	6.61e-195	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NLIIHIGN_00994	0.0	fucP	-	-	G	ko:K02429	-	ko00000,ko02000	Major Facilitator Superfamily
NLIIHIGN_00995	2.47e-88	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
NLIIHIGN_00996	2.26e-214	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLIIHIGN_00997	0.0	-	-	-	M	-	-	-	Rib/alpha-like repeat
NLIIHIGN_00998	0.0	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NLIIHIGN_00999	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_01000	3.99e-178	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01001	2.25e-288	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
NLIIHIGN_01002	1.69e-278	nupG	-	-	F	ko:K03317,ko:K11535,ko:K16323	-	ko00000,ko02000	Nucleoside transporter
NLIIHIGN_01003	2.47e-220	rihA	3.2.2.1	-	F	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	ko00000,ko00001,ko01000	Nucleoside
NLIIHIGN_01004	1.08e-210	-	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	3-hydroxyacyl-CoA dehydrogenase
NLIIHIGN_01005	9.71e-167	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
NLIIHIGN_01006	3.57e-198	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
NLIIHIGN_01007	8.34e-180	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
NLIIHIGN_01008	3.96e-197	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
NLIIHIGN_01009	8.24e-43	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
NLIIHIGN_01010	6.1e-255	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
NLIIHIGN_01011	6.3e-175	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
NLIIHIGN_01012	8.4e-259	xerS	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01014	1.76e-94	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
NLIIHIGN_01015	2.35e-101	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
NLIIHIGN_01016	4.83e-229	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NLIIHIGN_01017	2.51e-47	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLIIHIGN_01018	3.03e-207	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
NLIIHIGN_01019	7.69e-170	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
NLIIHIGN_01020	1.27e-288	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
NLIIHIGN_01021	1.3e-99	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
NLIIHIGN_01022	1.38e-98	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
NLIIHIGN_01023	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
NLIIHIGN_01024	7.2e-185	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NLIIHIGN_01025	5.87e-181	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	alpha subunit
NLIIHIGN_01026	4.25e-172	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
NLIIHIGN_01035	6.39e-73	-	-	-	-	-	-	-	-
NLIIHIGN_01036	2.23e-150	frnE	5.3.4.1	-	Q	ko:K01829	-	ko00000,ko01000	DSBA-like thioredoxin domain
NLIIHIGN_01037	5.51e-213	-	-	-	I	-	-	-	alpha/beta hydrolase fold
NLIIHIGN_01038	2.86e-63	-	-	-	L	ko:K07491	-	ko00000	PFAM transposase IS200-family protein
NLIIHIGN_01039	3.7e-11	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01040	1.54e-05	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01041	3.01e-63	int2	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01043	1.94e-64	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
NLIIHIGN_01044	3.73e-203	-	3.1.3.102, 3.1.3.104	-	S	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
NLIIHIGN_01045	1.38e-117	ntd	2.4.2.6	-	F	ko:K08728	ko00240,map00240	ko00000,ko00001,ko01000	Nucleoside
NLIIHIGN_01046	1.36e-212	-	-	-	S	-	-	-	Polyphosphate nucleotide phosphotransferase, PPK2 family
NLIIHIGN_01047	1.56e-80	-	-	-	-	-	-	-	-
NLIIHIGN_01048	3.37e-272	yttB	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_01049	3.65e-308	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
NLIIHIGN_01050	1.25e-97	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
NLIIHIGN_01051	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
NLIIHIGN_01052	9.36e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NLIIHIGN_01053	1.03e-114	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
NLIIHIGN_01054	4.55e-64	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
NLIIHIGN_01055	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NLIIHIGN_01056	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NLIIHIGN_01057	2.07e-262	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NLIIHIGN_01058	5.41e-47	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
NLIIHIGN_01059	8.49e-265	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
NLIIHIGN_01060	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NLIIHIGN_01061	7.96e-21	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
NLIIHIGN_01062	9.81e-77	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
NLIIHIGN_01063	2.96e-172	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
NLIIHIGN_01064	3.01e-177	jag	-	-	S	ko:K06346	-	ko00000	R3H domain protein
NLIIHIGN_01065	3.03e-83	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
NLIIHIGN_01066	0.0	-	-	-	E	ko:K03294	-	ko00000	amino acid
NLIIHIGN_01067	5.46e-183	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
NLIIHIGN_01068	1.86e-119	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NLIIHIGN_01069	3.74e-53	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
NLIIHIGN_01070	1.21e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
NLIIHIGN_01071	0.0	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NLIIHIGN_01072	4.23e-76	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NLIIHIGN_01073	2.44e-292	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
NLIIHIGN_01074	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
NLIIHIGN_01075	1.57e-168	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
NLIIHIGN_01076	1.81e-50	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLIIHIGN_01077	1.41e-242	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
NLIIHIGN_01078	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NLIIHIGN_01079	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
NLIIHIGN_01080	1.05e-77	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
NLIIHIGN_01081	1.1e-34	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
NLIIHIGN_01082	6.95e-159	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
NLIIHIGN_01083	2.22e-151	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
NLIIHIGN_01084	1.59e-213	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
NLIIHIGN_01085	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
NLIIHIGN_01086	5.19e-169	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
NLIIHIGN_01087	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NLIIHIGN_01088	1.81e-225	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NLIIHIGN_01089	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NLIIHIGN_01090	1.97e-276	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NLIIHIGN_01091	6.66e-43	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
NLIIHIGN_01092	1.78e-147	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
NLIIHIGN_01093	9e-72	-	-	-	-	-	-	-	-
NLIIHIGN_01094	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
NLIIHIGN_01095	6.71e-102	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
NLIIHIGN_01096	1.69e-192	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
NLIIHIGN_01097	3.59e-207	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
NLIIHIGN_01098	9.86e-59	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NLIIHIGN_01099	2.05e-282	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NLIIHIGN_01100	2.71e-200	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NLIIHIGN_01101	9.11e-92	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NLIIHIGN_01102	2.27e-93	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
NLIIHIGN_01103	7.45e-158	-	-	-	J	-	-	-	2'-5' RNA ligase superfamily
NLIIHIGN_01104	3.85e-259	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
NLIIHIGN_01105	5.46e-170	-	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NLIIHIGN_01106	5.07e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
NLIIHIGN_01107	8.76e-73	ysxB	-	-	J	ko:K07584	-	ko00000	Cysteine protease Prp
NLIIHIGN_01108	2.68e-67	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
NLIIHIGN_01109	5.7e-146	-	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_01112	3.61e-117	-	-	-	S	-	-	-	Protein conserved in bacteria
NLIIHIGN_01113	6.94e-238	-	-	-	-	-	-	-	-
NLIIHIGN_01114	8.42e-204	-	-	-	-	-	-	-	-
NLIIHIGN_01115	7.62e-68	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
NLIIHIGN_01116	6.94e-132	msrA	1.8.4.11	-	C	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NLIIHIGN_01117	1.03e-55	-	-	-	S	-	-	-	Fic/DOC family
NLIIHIGN_01118	1.11e-52	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
NLIIHIGN_01119	4.61e-66	-	-	-	M	-	-	-	LPXTG-motif cell wall anchor domain protein
NLIIHIGN_01120	1.94e-94	-	-	-	L	-	-	-	Transposase
NLIIHIGN_01121	1.88e-11	-	-	-	L	-	-	-	Transposase
NLIIHIGN_01122	5.78e-64	-	-	-	E	-	-	-	Filamentation induced by cAMP protein fic
NLIIHIGN_01126	1.63e-45	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01128	5.47e-55	-	-	-	S	-	-	-	Cytochrome B5
NLIIHIGN_01129	8.47e-08	-	-	-	S	-	-	-	Cytochrome B5
NLIIHIGN_01130	3.26e-52	-	-	-	S	-	-	-	Cytochrome B5
NLIIHIGN_01131	8.94e-100	-	-	-	S	ko:K02348	-	ko00000	Gnat family
NLIIHIGN_01132	6.67e-158	-	-	-	GM	-	-	-	NmrA-like family
NLIIHIGN_01133	2.74e-69	ydeP	-	-	K	-	-	-	Transcriptional regulator, HxlR family
NLIIHIGN_01134	1.41e-141	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
NLIIHIGN_01135	1.85e-108	-	-	-	K	-	-	-	Transcriptional regulator, HxlR family
NLIIHIGN_01136	2.28e-307	-	-	-	-	-	-	-	-
NLIIHIGN_01137	2.65e-269	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
NLIIHIGN_01138	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
NLIIHIGN_01139	3.7e-148	-	-	-	GM	-	-	-	NAD dependent epimerase dehydratase family protein
NLIIHIGN_01140	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
NLIIHIGN_01141	1.37e-123	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
NLIIHIGN_01142	1.23e-253	asnA	6.3.1.1	-	F	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	ko00000,ko00001,ko01000	aspartate--ammonia ligase
NLIIHIGN_01143	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
NLIIHIGN_01144	2.7e-161	-	-	-	T	-	-	-	Putative diguanylate phosphodiesterase
NLIIHIGN_01145	1.44e-262	-	2.7.7.65	-	T	ko:K02488	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko00002,ko01000,ko02022	GGDEF domain
NLIIHIGN_01146	7.04e-118	-	-	-	-	-	-	-	-
NLIIHIGN_01147	0.0	yijG	-	GT2	M	ko:K11936	ko02026,map02026	ko00000,ko00001,ko01000,ko01003,ko02000	Glycosyl transferase
NLIIHIGN_01148	1.07e-205	-	-	-	T	-	-	-	EAL domain
NLIIHIGN_01149	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NLIIHIGN_01150	1.74e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NLIIHIGN_01151	1.44e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
NLIIHIGN_01152	5.84e-203	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
NLIIHIGN_01153	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
NLIIHIGN_01154	5e-116	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
NLIIHIGN_01155	8.7e-141	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
NLIIHIGN_01156	2.58e-253	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
NLIIHIGN_01157	3.05e-116	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NLIIHIGN_01158	2.37e-129	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
NLIIHIGN_01159	3.83e-61	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
NLIIHIGN_01160	2.75e-286	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
NLIIHIGN_01161	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
NLIIHIGN_01162	2.12e-178	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
NLIIHIGN_01163	2.02e-63	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
NLIIHIGN_01164	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
NLIIHIGN_01165	1.34e-314	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
NLIIHIGN_01166	2.31e-232	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, C-terminal domain protein
NLIIHIGN_01167	2.44e-267	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
NLIIHIGN_01168	5.42e-276	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
NLIIHIGN_01169	6.61e-194	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01170	0.0	araP	-	-	U	-	-	-	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
NLIIHIGN_01171	0.0	araB	2.7.1.16	-	G	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	carbohydrate kinase FGGY
NLIIHIGN_01172	2.32e-179	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
NLIIHIGN_01173	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
NLIIHIGN_01174	5.39e-136	maa	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose O-acetyltransferase
NLIIHIGN_01175	3.74e-204	yvgN	-	-	S	-	-	-	Aldo keto reductase
NLIIHIGN_01176	1.3e-265	araR	-	-	K	ko:K02103	-	ko00000,ko03000	Transcriptional regulator
NLIIHIGN_01177	1.95e-109	uspA	-	-	T	-	-	-	universal stress protein
NLIIHIGN_01178	3.61e-61	-	-	-	-	-	-	-	-
NLIIHIGN_01179	4.83e-312	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
NLIIHIGN_01180	3.65e-114	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
NLIIHIGN_01181	1.14e-27	-	-	-	-	-	-	-	-
NLIIHIGN_01182	2e-98	-	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase
NLIIHIGN_01183	4.16e-180	-	-	-	S	-	-	-	Membrane
NLIIHIGN_01184	1.24e-182	-	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
NLIIHIGN_01185	0.0	spxB	1.2.3.3, 1.2.5.1, 2.2.1.6, 4.1.1.8	-	EH	ko:K00156,ko:K00158,ko:K01577,ko:K01652	ko00290,ko00620,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
NLIIHIGN_01186	1.93e-208	frc	2.8.3.16	-	C	ko:K07749	-	ko00000,ko01000	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate
NLIIHIGN_01187	5.67e-53	-	-	-	S	-	-	-	Protein of unknown function (DUF1797)
NLIIHIGN_01188	3.64e-226	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NLIIHIGN_01189	4.82e-254	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
NLIIHIGN_01190	1.88e-292	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
NLIIHIGN_01191	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NLIIHIGN_01192	3.69e-54	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
NLIIHIGN_01193	9.69e-38	-	-	-	-	-	-	-	-
NLIIHIGN_01194	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
NLIIHIGN_01195	6.36e-130	-	-	-	S	-	-	-	Pfam:DUF3816
NLIIHIGN_01196	9.48e-183	-	-	-	G	-	-	-	MucBP domain
NLIIHIGN_01197	1.27e-151	-	-	-	-	-	-	-	-
NLIIHIGN_01198	2.62e-201	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01199	7.18e-86	-	-	-	K	-	-	-	Transcriptional regulator, GntR family
NLIIHIGN_01200	3.74e-241	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_01201	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NLIIHIGN_01202	4.39e-297	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
NLIIHIGN_01203	1.77e-230	yueF	-	-	S	-	-	-	AI-2E family transporter
NLIIHIGN_01204	6.64e-253	csd1	3.5.1.28	-	M	ko:K01447,ko:K17733,ko:K19117	-	ko00000,ko01000,ko01002,ko01011,ko02048	N-Acetylmuramoyl-L-alanine amidase
NLIIHIGN_01205	7.32e-124	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
NLIIHIGN_01206	2.21e-167	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
NLIIHIGN_01207	3.14e-197	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NLIIHIGN_01208	3.54e-184	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
NLIIHIGN_01209	8.74e-235	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLIIHIGN_01210	6.79e-65	yazA	-	-	L	ko:K07461	-	ko00000	GIY-YIG catalytic domain protein
NLIIHIGN_01211	2.92e-182	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
NLIIHIGN_01212	1.84e-152	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
NLIIHIGN_01213	1.6e-40	XK26_06720	-	-	S	ko:K09976	-	ko00000	Uncharacterised protein family (UPF0154)
NLIIHIGN_01214	2.7e-47	ynzC	-	-	S	-	-	-	UPF0291 protein
NLIIHIGN_01215	2.52e-148	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NLIIHIGN_01216	1.49e-272	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
NLIIHIGN_01217	3.18e-167	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NLIIHIGN_01219	7.41e-130	-	-	-	-	-	-	-	-
NLIIHIGN_01220	1.25e-119	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NLIIHIGN_01221	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
NLIIHIGN_01222	1.75e-200	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
NLIIHIGN_01223	2.39e-226	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
NLIIHIGN_01224	0.0	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NLIIHIGN_01225	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
NLIIHIGN_01226	2.44e-20	-	-	-	-	-	-	-	-
NLIIHIGN_01227	4.78e-09	-	-	-	E	-	-	-	Protein of unknown function (DUF3923)
NLIIHIGN_01228	1.21e-292	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
NLIIHIGN_01229	6.2e-155	-	-	-	M	-	-	-	Protein of unknown function (DUF3737)
NLIIHIGN_01230	2e-73	yphJ	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	decarboxylase
NLIIHIGN_01231	1.15e-15	-	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	Oxidoreductase, aldo keto reductase family protein
NLIIHIGN_01232	5e-116	-	-	-	C	-	-	-	Flavodoxin
NLIIHIGN_01233	1.35e-206	lysR	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_01234	2.21e-115	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	transferase hexapeptide repeat
NLIIHIGN_01235	1.48e-05	-	-	-	S	-	-	-	Hydrolases of the alpha beta superfamily
NLIIHIGN_01236	3.16e-170	-	-	-	S	-	-	-	Alpha beta hydrolase
NLIIHIGN_01237	5.93e-196	mhpD	-	-	Q	ko:K02509	ko00350,ko01120,map00350,map01120	ko00000,ko00001,ko01000	hydratase
NLIIHIGN_01238	2.28e-223	hdhL	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
NLIIHIGN_01239	4.77e-291	aadAT	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	Aminotransferase, class I
NLIIHIGN_01240	1.45e-214	ypuA	-	-	S	-	-	-	Protein of unknown function (DUF1002)
NLIIHIGN_01241	3.43e-236	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase, type I
NLIIHIGN_01242	1.64e-203	-	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_01243	4.38e-209	akr5f	1.1.1.346	-	S	ko:K06221	-	ko00000,ko01000	reductase
NLIIHIGN_01244	6.78e-136	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
NLIIHIGN_01245	6.54e-253	-	-	-	S	-	-	-	membrane
NLIIHIGN_01246	1.15e-147	-	-	-	GM	-	-	-	NAD(P)H-binding
NLIIHIGN_01247	1.74e-85	-	-	-	-	-	-	-	-
NLIIHIGN_01248	4.18e-168	-	-	-	F	-	-	-	glutamine amidotransferase
NLIIHIGN_01249	3.75e-177	wchF	-	GT4	M	ko:K12996	-	ko00000,ko01000,ko01003,ko01005	Domain of unknown function (DUF1972)
NLIIHIGN_01250	1.51e-100	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
NLIIHIGN_01251	2.04e-83	-	-	-	M	-	-	-	Capsular polysaccharide synthesis protein
NLIIHIGN_01252	3.48e-147	cps1C	-	-	S	ko:K03328	-	ko00000	Membrane protein involved in the export of O-antigen and teichoic acid
NLIIHIGN_01253	1.57e-06	-	-	-	S	-	-	-	Glycosyltransferase like family 2
NLIIHIGN_01255	2.94e-120	-	-	-	M	-	-	-	Glycosyl transferases group 1
NLIIHIGN_01256	3.17e-26	-	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	serine acetyltransferase
NLIIHIGN_01257	4.24e-163	-	-	-	O	-	-	-	Bacterial dnaA protein
NLIIHIGN_01258	1.18e-274	-	-	-	L	-	-	-	Integrase core domain
NLIIHIGN_01259	4.64e-53	-	-	-	L	ko:K07491	-	ko00000	PFAM transposase IS200-family protein
NLIIHIGN_01260	1.15e-34	-	-	-	-	-	-	-	-
NLIIHIGN_01261	1.67e-56	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	PemK-like, MazF-like toxin of type II toxin-antitoxin system
NLIIHIGN_01262	1.21e-124	-	-	-	-	-	-	-	-
NLIIHIGN_01263	1.65e-08	-	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
NLIIHIGN_01265	9.44e-164	-	1.6.5.2	-	GM	ko:K19267	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NAD(P)H-binding
NLIIHIGN_01267	1.36e-39	-	-	-	S	-	-	-	Protein of unknown function (DUF4065)
NLIIHIGN_01268	3.87e-40	doc	-	-	-	ko:K07341	-	ko00000,ko02048	-
NLIIHIGN_01269	6.94e-50	doc	-	-	S	ko:K07341	-	ko00000,ko02048	Fic/DOC family
NLIIHIGN_01270	1.21e-14	-	-	-	-	-	-	-	-
NLIIHIGN_01271	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	Putative exonuclease SbcCD, C subunit
NLIIHIGN_01272	1.25e-262	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
NLIIHIGN_01273	2.22e-185	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
NLIIHIGN_01274	0.0	snf	-	-	KL	-	-	-	domain protein
NLIIHIGN_01276	2.74e-50	-	-	-	-	ko:K18829	-	ko00000,ko02048	-
NLIIHIGN_01277	4.36e-90	-	-	-	T	ko:K07171	-	ko00000,ko01000,ko02048	Toxin-antitoxin system, toxin component, MazF family
NLIIHIGN_01279	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
NLIIHIGN_01280	4.6e-220	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine S-methyltransferase
NLIIHIGN_01283	9.36e-42	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
NLIIHIGN_01284	5.96e-139	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NLIIHIGN_01285	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NLIIHIGN_01286	2.59e-276	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
NLIIHIGN_01287	4.1e-292	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NLIIHIGN_01288	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
NLIIHIGN_01289	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
NLIIHIGN_01290	2.07e-237	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
NLIIHIGN_01291	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
NLIIHIGN_01292	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NLIIHIGN_01293	1.05e-293	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
NLIIHIGN_01294	2.85e-316	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
NLIIHIGN_01295	2.81e-297	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
NLIIHIGN_01296	5.51e-264	yngD	-	-	S	ko:K07097	-	ko00000	DHHA1 domain
NLIIHIGN_01297	2.48e-66	-	-	-	-	-	-	-	-
NLIIHIGN_01298	3.89e-183	-	-	-	S	-	-	-	PD-(D/E)XK nuclease family transposase
NLIIHIGN_01300	8.14e-73	-	-	-	-	-	-	-	-
NLIIHIGN_01301	2.8e-159	yrkL	-	-	S	-	-	-	Flavodoxin-like fold
NLIIHIGN_01303	1.92e-86	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
NLIIHIGN_01304	8.15e-155	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
NLIIHIGN_01305	1e-268	-	-	-	S	-	-	-	associated with various cellular activities
NLIIHIGN_01306	2.59e-314	-	-	-	S	-	-	-	Putative metallopeptidase domain
NLIIHIGN_01307	1.48e-64	-	-	-	-	-	-	-	-
NLIIHIGN_01308	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
NLIIHIGN_01309	1.03e-146	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01310	8.53e-120	ymdB	-	-	S	-	-	-	Macro domain protein
NLIIHIGN_01311	1.57e-173	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_01312	2.37e-59	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_01313	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLIIHIGN_01314	1.43e-102	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	Gluconate
NLIIHIGN_01315	2.04e-234	-	-	-	K	ko:K02525	-	ko00000,ko03000	Transcriptional regulator, LacI family
NLIIHIGN_01316	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
NLIIHIGN_01317	1.89e-123	-	-	-	-	-	-	-	-
NLIIHIGN_01318	1.04e-33	-	-	-	-	-	-	-	-
NLIIHIGN_01319	8.08e-83	asp1	-	-	S	-	-	-	Asp23 family, cell envelope-related function
NLIIHIGN_01320	7.63e-117	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
NLIIHIGN_01322	9.14e-66	-	-	-	-	-	-	-	-
NLIIHIGN_01323	2.59e-89	-	-	-	S	-	-	-	Belongs to the HesB IscA family
NLIIHIGN_01324	1.81e-222	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
NLIIHIGN_01325	2.41e-111	-	-	-	F	-	-	-	NUDIX domain
NLIIHIGN_01326	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NLIIHIGN_01327	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
NLIIHIGN_01328	1.9e-139	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
NLIIHIGN_01329	1.66e-213	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
NLIIHIGN_01330	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NLIIHIGN_01331	6.71e-208	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
NLIIHIGN_01332	1.06e-182	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NLIIHIGN_01333	1.46e-206	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NLIIHIGN_01334	1.33e-47	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
NLIIHIGN_01335	2.85e-141	ypmS	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2140)
NLIIHIGN_01336	4.59e-219	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
NLIIHIGN_01337	4.49e-196	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
NLIIHIGN_01338	2.59e-144	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
NLIIHIGN_01339	4.1e-120	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NLIIHIGN_01340	1.26e-247	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NLIIHIGN_01341	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01342	2.55e-289	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
NLIIHIGN_01343	2.33e-301	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
NLIIHIGN_01344	1.6e-54	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
NLIIHIGN_01345	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
NLIIHIGN_01346	1.49e-274	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
NLIIHIGN_01347	3.8e-153	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
NLIIHIGN_01348	2.15e-83	-	-	-	M	-	-	-	Lysin motif
NLIIHIGN_01349	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
NLIIHIGN_01350	1.6e-247	-	-	-	S	-	-	-	Helix-turn-helix domain
NLIIHIGN_01351	2.65e-133	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NLIIHIGN_01352	1.18e-163	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
NLIIHIGN_01353	1.57e-134	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NLIIHIGN_01354	2.37e-178	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NLIIHIGN_01355	3.67e-86	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
NLIIHIGN_01356	4.23e-214	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
NLIIHIGN_01357	2.27e-216	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
NLIIHIGN_01358	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
NLIIHIGN_01359	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
NLIIHIGN_01360	7.81e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
NLIIHIGN_01361	1.45e-185	lysA2	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
NLIIHIGN_01362	3.82e-45	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
NLIIHIGN_01369	2.6e-30	-	-	-	S	-	-	-	peptidoglycan catabolic process
NLIIHIGN_01370	0.0	tagE3	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
NLIIHIGN_01371	5.08e-237	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
NLIIHIGN_01372	6.25e-216	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
NLIIHIGN_01373	6.52e-75	-	-	-	S	-	-	-	Small secreted protein
NLIIHIGN_01374	2.95e-75	ytpP	-	-	CO	-	-	-	Thioredoxin
NLIIHIGN_01375	3.43e-154	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
NLIIHIGN_01376	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
NLIIHIGN_01377	4.56e-154	ybhL	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
NLIIHIGN_01378	5.87e-155	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
NLIIHIGN_01379	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NLIIHIGN_01380	3.89e-204	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
NLIIHIGN_01381	5.5e-134	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NLIIHIGN_01382	2.82e-105	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NLIIHIGN_01383	2.83e-299	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	replication initiation and membrane attachment
NLIIHIGN_01384	1.05e-222	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
NLIIHIGN_01385	2.15e-110	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NLIIHIGN_01386	1.82e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
NLIIHIGN_01387	5.46e-74	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NLIIHIGN_01388	1.31e-286	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
NLIIHIGN_01389	3.59e-128	-	-	-	S	-	-	-	AmiS/UreI family transporter
NLIIHIGN_01390	8.76e-63	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Urease, gamma subunit
NLIIHIGN_01391	1.15e-83	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Urease beta subunit
NLIIHIGN_01392	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Amidohydrolase family
NLIIHIGN_01393	3.08e-102	ureE	-	-	O	ko:K03187	-	ko00000	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NLIIHIGN_01394	1.45e-170	ureF	-	-	O	ko:K03188	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
NLIIHIGN_01395	1.4e-145	ureG	-	-	KO	ko:K03189	-	ko00000	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NLIIHIGN_01396	9.18e-207	ureD	-	-	O	ko:K03190	-	ko00000	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
NLIIHIGN_01397	2e-56	-	-	-	U	-	-	-	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLIIHIGN_01398	4.2e-96	-	-	-	U	-	-	-	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLIIHIGN_01399	2.33e-238	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PDGLE domain
NLIIHIGN_01400	4.06e-184	-	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
NLIIHIGN_01401	9.42e-174	-	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
NLIIHIGN_01402	2.8e-168	-	-	-	K	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C-terminal domain protein
NLIIHIGN_01403	1.71e-205	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
NLIIHIGN_01404	1.95e-195	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
NLIIHIGN_01405	2.7e-199	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
NLIIHIGN_01406	3.14e-177	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
NLIIHIGN_01407	6.09e-162	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
NLIIHIGN_01408	1e-31	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
NLIIHIGN_01409	1.58e-90	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
NLIIHIGN_01410	1.98e-233	cbh	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolase, choloylglycine hydrolase family protein
NLIIHIGN_01411	1.46e-303	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
NLIIHIGN_01412	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
NLIIHIGN_01413	7.24e-121	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
NLIIHIGN_01414	1.49e-227	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
NLIIHIGN_01415	6.39e-235	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
NLIIHIGN_01416	1.55e-109	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NLIIHIGN_01417	1.8e-81	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
NLIIHIGN_01418	2.66e-219	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NLIIHIGN_01419	1.24e-188	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
NLIIHIGN_01420	2.14e-234	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
NLIIHIGN_01421	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
NLIIHIGN_01422	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
NLIIHIGN_01423	5.12e-266	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
NLIIHIGN_01424	1.78e-83	-	-	-	-	-	-	-	-
NLIIHIGN_01425	3.18e-11	-	-	-	-	-	-	-	-
NLIIHIGN_01426	6.26e-156	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
NLIIHIGN_01427	4.99e-179	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
NLIIHIGN_01428	7.68e-264	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_01429	0.0	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system Galactitol-specific IIC component
NLIIHIGN_01430	5.65e-230	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
NLIIHIGN_01431	1.47e-208	-	-	-	-	-	-	-	-
NLIIHIGN_01432	1.3e-95	-	-	-	K	-	-	-	Transcriptional regulator
NLIIHIGN_01433	8.47e-240	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
NLIIHIGN_01434	1.5e-67	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
NLIIHIGN_01435	0.0	nhaK	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
NLIIHIGN_01436	6.5e-71	-	-	-	-	-	-	-	-
NLIIHIGN_01437	1.75e-148	-	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
NLIIHIGN_01438	4.52e-316	-	-	-	S	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01439	1.73e-126	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
NLIIHIGN_01440	1.03e-171	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
NLIIHIGN_01441	1.56e-70	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
NLIIHIGN_01442	1.02e-228	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01443	7.13e-162	-	-	-	L	-	-	-	Type I restriction modification DNA specificity domain
NLIIHIGN_01444	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
NLIIHIGN_01445	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
NLIIHIGN_01446	1.48e-178	butA	1.1.1.304, 1.1.1.76	-	IQ	ko:K03366	ko00650,map00650	ko00000,ko00001,ko01000	reductase
NLIIHIGN_01447	2.75e-105	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
NLIIHIGN_01448	1.26e-60	-	-	-	-	-	-	-	-
NLIIHIGN_01449	0.0	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
NLIIHIGN_01450	2.58e-41	-	-	-	-	-	-	-	-
NLIIHIGN_01451	3.8e-63	-	-	-	-	-	-	-	-
NLIIHIGN_01452	2.93e-125	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
NLIIHIGN_01453	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
NLIIHIGN_01454	3.7e-19	-	-	-	-	-	-	-	-
NLIIHIGN_01455	1.58e-110	-	-	-	S	-	-	-	Domain of unknown function (DUF4767)
NLIIHIGN_01456	3.39e-254	-	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
NLIIHIGN_01457	2.26e-149	-	-	-	S	-	-	-	Membrane
NLIIHIGN_01458	1.1e-161	-	-	-	O	-	-	-	Zinc-dependent metalloprotease
NLIIHIGN_01459	3.82e-114	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
NLIIHIGN_01460	2.51e-201	metQ1	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
NLIIHIGN_01462	7.01e-233	-	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
NLIIHIGN_01463	4.8e-128	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NLIIHIGN_01464	2.48e-217	-	-	-	-	-	-	-	-
NLIIHIGN_01465	5.53e-52	ptpA	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NLIIHIGN_01466	1.11e-263	-	1.1.1.90	-	C	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Zn-dependent alcohol dehydrogenases, class III
NLIIHIGN_01467	1.93e-210	-	-	-	K	-	-	-	LysR substrate binding domain
NLIIHIGN_01468	4.87e-179	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
NLIIHIGN_01469	9.45e-126	-	-	-	K	-	-	-	acetyltransferase
NLIIHIGN_01470	6.68e-238	-	-	-	-	-	-	-	-
NLIIHIGN_01472	1.46e-203	endA	-	-	V	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
NLIIHIGN_01473	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
NLIIHIGN_01476	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NLIIHIGN_01477	3.41e-296	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
NLIIHIGN_01478	2.9e-158	-	-	-	S	-	-	-	SNARE associated Golgi protein
NLIIHIGN_01479	0.0	uvrA2	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC, A subunit
NLIIHIGN_01480	1.27e-72	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLIIHIGN_01481	7.82e-80	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLIIHIGN_01482	3.39e-90	-	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
NLIIHIGN_01483	4.15e-192	-	-	-	S	-	-	-	DUF218 domain
NLIIHIGN_01484	0.0	ubiB	-	-	S	ko:K03688	-	ko00000	ABC1 family
NLIIHIGN_01485	9.45e-315	yhdP	-	-	S	-	-	-	Transporter associated domain
NLIIHIGN_01486	4.08e-248	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
NLIIHIGN_01487	7.46e-106	uspA3	-	-	T	-	-	-	universal stress protein
NLIIHIGN_01488	0.0	fusA1	-	-	J	-	-	-	elongation factor G
NLIIHIGN_01489	1.47e-211	-	-	-	GK	-	-	-	ROK family
NLIIHIGN_01490	6.87e-311	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
NLIIHIGN_01491	2.6e-179	yfhR3	-	-	S	ko:K06889	-	ko00000	Serine hydrolase (FSH1)
NLIIHIGN_01492	3.37e-307	-	-	-	E	-	-	-	amino acid
NLIIHIGN_01493	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
NLIIHIGN_01494	4.81e-36	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
NLIIHIGN_01495	7.17e-83	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
NLIIHIGN_01496	7.12e-170	gntR	-	-	K	-	-	-	UbiC transcription regulator-associated domain protein
NLIIHIGN_01497	1.93e-112	ebsC	-	-	J	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NLIIHIGN_01498	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
NLIIHIGN_01499	2.88e-229	-	-	-	-	-	-	-	-
NLIIHIGN_01500	5.27e-169	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NLIIHIGN_01501	7.07e-311	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
NLIIHIGN_01502	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
NLIIHIGN_01503	2.37e-135	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NLIIHIGN_01504	3.24e-249	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
NLIIHIGN_01505	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NLIIHIGN_01506	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NLIIHIGN_01507	1.98e-163	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NLIIHIGN_01508	4.5e-50	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NLIIHIGN_01509	4.3e-169	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
NLIIHIGN_01510	0.0	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NLIIHIGN_01511	1.18e-273	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NLIIHIGN_01512	5.18e-109	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NLIIHIGN_01513	1.17e-95	gtcA	-	-	S	-	-	-	Teichoic acid glycosylation protein
NLIIHIGN_01514	4.7e-103	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
NLIIHIGN_01515	4.08e-215	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
NLIIHIGN_01516	4.15e-282	arcT	-	-	E	-	-	-	Aminotransferase
NLIIHIGN_01517	1.24e-201	arcD	-	-	E	ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
NLIIHIGN_01518	9.04e-90	arcD	-	-	E	ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
NLIIHIGN_01519	8.77e-58	potE	-	-	E	-	-	-	Amino Acid
NLIIHIGN_01520	2.04e-271	potE	-	-	E	-	-	-	Amino Acid
NLIIHIGN_01521	9.09e-204	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
NLIIHIGN_01522	8.85e-47	-	-	-	S	-	-	-	Protein of unknown function (DUF2922)
NLIIHIGN_01523	6.21e-43	-	-	-	-	-	-	-	-
NLIIHIGN_01524	6.03e-177	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
NLIIHIGN_01525	1.29e-187	cps1D	-	-	M	-	-	-	Domain of unknown function (DUF4422)
NLIIHIGN_01526	7.67e-223	yfdH	-	GT2	M	ko:K12999	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
NLIIHIGN_01527	6.93e-154	-	-	-	M	-	-	-	Bacterial sugar transferase
NLIIHIGN_01528	0.0	spoIIQ	-	-	M	ko:K06386	-	ko00000	Peptidase family M23
NLIIHIGN_01529	6.58e-152	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NLIIHIGN_01530	9.76e-300	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NLIIHIGN_01531	4.23e-305	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	pyrimidine-nucleoside phosphorylase
NLIIHIGN_01532	3.27e-167	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
NLIIHIGN_01533	2.28e-220	deoR	-	-	K	ko:K05346	-	ko00000,ko03000	sugar-binding domain protein
NLIIHIGN_01534	1.47e-265	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
NLIIHIGN_01535	9.76e-161	vanR	-	-	K	-	-	-	response regulator
NLIIHIGN_01536	1.36e-266	hpk31	-	-	T	-	-	-	Histidine kinase
NLIIHIGN_01537	6.03e-196	-	-	-	E	-	-	-	AzlC protein
NLIIHIGN_01538	1.65e-69	-	-	-	S	-	-	-	branched-chain amino acid
NLIIHIGN_01539	1.3e-156	-	-	-	K	ko:K09681	-	ko00000,ko03000	DNA-binding transcription factor activity
NLIIHIGN_01540	1.56e-20	-	-	-	K	-	-	-	LysR substrate binding domain
NLIIHIGN_01541	1.81e-221	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
NLIIHIGN_01542	3.19e-315	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
NLIIHIGN_01543	2.77e-220	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
NLIIHIGN_01544	1.96e-167	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
NLIIHIGN_01545	6.66e-151	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NLIIHIGN_01546	1.11e-149	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
NLIIHIGN_01547	2.62e-122	ribB	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NLIIHIGN_01548	7.79e-290	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
NLIIHIGN_01549	3.86e-223	ydbI	-	-	K	-	-	-	AI-2E family transporter
NLIIHIGN_01550	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
NLIIHIGN_01551	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
NLIIHIGN_01552	6.88e-170	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Belongs to the alpha-acetolactate decarboxylase family
NLIIHIGN_01553	3.06e-28	rhaS4	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
NLIIHIGN_01554	8.37e-231	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
NLIIHIGN_01555	1.2e-217	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
NLIIHIGN_01556	1.42e-126	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
NLIIHIGN_01557	3.89e-78	-	-	-	L	-	-	-	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
NLIIHIGN_01558	1.05e-233	-	-	-	L	-	-	-	PFAM RNA-directed DNA polymerase (Reverse transcriptase)
NLIIHIGN_01559	5.11e-137	tnp2	-	-	L	-	-	-	PFAM Transposase, IS204 IS1001 IS1096 IS1165
NLIIHIGN_01560	1.77e-93	tnp2	-	-	L	-	-	-	PFAM Transposase, IS204 IS1001 IS1096 IS1165
NLIIHIGN_01561	1.65e-151	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_01562	4.74e-223	fecB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
NLIIHIGN_01563	3.12e-176	fecE	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
NLIIHIGN_01564	4.18e-165	fecD	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLIIHIGN_01565	1.21e-99	-	-	-	S	-	-	-	Flavodoxin
NLIIHIGN_01566	3.25e-84	moaE	2.8.1.12	-	H	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	MoaE protein
NLIIHIGN_01567	4.04e-48	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	ThiS family
NLIIHIGN_01568	5.25e-279	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	Transporter, major facilitator family protein
NLIIHIGN_01569	3.34e-213	-	-	-	H	-	-	-	geranyltranstransferase activity
NLIIHIGN_01570	2.71e-234	-	-	-	-	-	-	-	-
NLIIHIGN_01571	2.45e-26	-	-	-	-	-	-	-	-
NLIIHIGN_01572	3.03e-149	nreC	-	-	K	ko:K07696	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	PFAM regulatory protein LuxR
NLIIHIGN_01573	5.31e-242	nreB	2.7.13.3	-	F	ko:K07683	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Sensor histidine kinase
NLIIHIGN_01574	1.56e-60	-	-	-	-	-	-	-	-
NLIIHIGN_01575	2.03e-136	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
NLIIHIGN_01576	9.66e-110	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
NLIIHIGN_01577	1.27e-290	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	MoeA N-terminal region (domain I and II)
NLIIHIGN_01578	4.94e-109	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
NLIIHIGN_01579	7.28e-243	moeB	2.7.7.80	-	H	ko:K21029	ko04122,map04122	ko00000,ko00001,ko01000	ThiF family
NLIIHIGN_01580	0.0	narZ	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NLIIHIGN_01581	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	4Fe-4S dicluster domain
NLIIHIGN_01582	2.97e-130	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	nitrate reductase molybdenum cofactor assembly chaperone
NLIIHIGN_01583	9.45e-168	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase
NLIIHIGN_01584	3.79e-40	-	-	-	L	ko:K07497	-	ko00000	PFAM Integrase catalytic region
NLIIHIGN_01585	1.18e-167	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
NLIIHIGN_01586	3.02e-135	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
NLIIHIGN_01587	1.74e-252	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NLIIHIGN_01588	1.87e-172	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLIIHIGN_01589	3.8e-292	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NLIIHIGN_01590	2.29e-180	proB	2.7.2.11	-	F	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NLIIHIGN_01591	3.05e-189	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
NLIIHIGN_01592	1.37e-292	mtnE	-	-	E	ko:K08969	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
NLIIHIGN_01593	2.61e-236	ykpB	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NLIIHIGN_01594	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
NLIIHIGN_01595	4.67e-147	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NLIIHIGN_01597	1.83e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NLIIHIGN_01598	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
NLIIHIGN_01599	0.0	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Membrane domain of glycerophosphoryl diester phosphodiesterase
NLIIHIGN_01600	6.51e-114	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
NLIIHIGN_01601	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
NLIIHIGN_01602	2.95e-239	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
NLIIHIGN_01603	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NLIIHIGN_01604	2.31e-131	-	-	-	-	-	-	-	-
NLIIHIGN_01605	1.14e-123	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NLIIHIGN_01607	3.62e-308	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_01608	4.72e-107	-	-	-	L	ko:K07491	-	ko00000	Transposase IS200 like
NLIIHIGN_01609	8.71e-178	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
NLIIHIGN_01610	5.46e-315	-	-	-	E	-	-	-	amino acid
NLIIHIGN_01611	1.64e-18	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
NLIIHIGN_01612	4.39e-94	-	-	-	K	-	-	-	Transcriptional regulator, TetR family
NLIIHIGN_01613	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NLIIHIGN_01614	2.06e-108	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
NLIIHIGN_01615	3.56e-94	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NLIIHIGN_01616	1.19e-154	comC	3.4.23.43	-	NOU	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	Bacterial Peptidase A24 N-terminal domain
NLIIHIGN_01617	3.31e-263	-	-	-	-	-	-	-	-
NLIIHIGN_01618	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NLIIHIGN_01619	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NLIIHIGN_01620	2.09e-143	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
NLIIHIGN_01621	2.18e-69	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
NLIIHIGN_01623	6.55e-97	-	-	-	K	ko:K18909	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
NLIIHIGN_01624	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
NLIIHIGN_01626	3.69e-168	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
NLIIHIGN_01627	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
NLIIHIGN_01628	0.0	yycH	-	-	S	-	-	-	YycH protein
NLIIHIGN_01629	6.38e-196	yycI	-	-	S	-	-	-	YycH protein
NLIIHIGN_01630	8.78e-197	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
NLIIHIGN_01631	6.24e-287	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
NLIIHIGN_01632	5.79e-117	pgpA	-	-	I	-	-	-	Phosphatidylglycerophosphatase A
NLIIHIGN_01633	1.02e-232	ABC-SBP	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
NLIIHIGN_01634	3.74e-115	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NLIIHIGN_01636	0.0	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
NLIIHIGN_01637	0.0	-	-	-	M	-	-	-	domain protein
NLIIHIGN_01638	2.51e-83	-	-	-	-	-	-	-	-
NLIIHIGN_01639	3e-251	ampC	-	-	V	-	-	-	Beta-lactamase
NLIIHIGN_01640	1.25e-304	arcA	3.5.3.6	-	E	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	ko00000,ko00001,ko01000	Arginine
NLIIHIGN_01641	6.17e-104	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
NLIIHIGN_01642	0.0	arcD	-	-	E	ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
NLIIHIGN_01643	6.17e-301	potE	-	-	U	ko:K03756,ko:K03758	-	ko00000,ko02000	Amino acid permease
NLIIHIGN_01644	2.24e-200	-	-	-	KT	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	YcbB domain
NLIIHIGN_01645	3.75e-243	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NLIIHIGN_01646	6.53e-220	arcC	2.7.2.2	-	E	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	ko00000,ko00001,ko01000	Belongs to the carbamate kinase family
NLIIHIGN_01647	1.92e-209	-	-	-	EG	-	-	-	EamA-like transporter family
NLIIHIGN_01648	1.04e-135	XK27_08875	-	-	O	-	-	-	PFAM peptidase M10A and M12B, matrixin and adamalysin
NLIIHIGN_01649	1.53e-71	-	-	-	S	-	-	-	Cupredoxin-like domain
NLIIHIGN_01650	2.2e-65	-	-	-	S	-	-	-	Cupredoxin-like domain
NLIIHIGN_01651	0.0	copA	3.6.3.3, 3.6.3.5, 3.6.3.54	-	P	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
NLIIHIGN_01652	1.69e-117	-	-	-	-	-	-	-	-
NLIIHIGN_01654	1.28e-75	-	-	-	-	-	-	-	-
NLIIHIGN_01655	1.05e-305	nhaP3	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
NLIIHIGN_01657	1.64e-142	-	-	-	-	-	-	-	-
NLIIHIGN_01658	0.0	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
NLIIHIGN_01659	1.01e-69	XK27_01125	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 family protein
NLIIHIGN_01661	5.16e-115	-	-	-	K	ko:K21562	-	ko00000,ko03000	Transcriptional regulator, Crp Fnr family
NLIIHIGN_01662	7.69e-100	-	-	-	-	-	-	-	-
NLIIHIGN_01663	1.39e-230	-	-	-	-	-	-	-	-
NLIIHIGN_01664	4.43e-51	-	-	-	L	-	-	-	transposase and inactivated derivatives, IS30 family
NLIIHIGN_01665	2.48e-143	-	-	-	L	-	-	-	PFAM Integrase catalytic region
NLIIHIGN_01666	5.32e-06	-	-	-	-	-	-	-	-
NLIIHIGN_01667	2.46e-72	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
NLIIHIGN_01668	2.96e-106	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NLIIHIGN_01669	3.1e-268	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
NLIIHIGN_01670	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
NLIIHIGN_01672	9.63e-291	aadAT	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	Aminotransferase, class I
NLIIHIGN_01673	8.31e-158	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
NLIIHIGN_01674	1.39e-92	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NLIIHIGN_01675	1.1e-126	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
NLIIHIGN_01676	7.11e-32	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
NLIIHIGN_01677	9.18e-31	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
NLIIHIGN_01678	1.82e-175	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NLIIHIGN_01679	2.16e-94	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NLIIHIGN_01680	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
NLIIHIGN_01681	4.28e-225	yjbO	5.4.99.23	-	G	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
NLIIHIGN_01682	1.52e-198	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NLIIHIGN_01683	9.06e-151	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
NLIIHIGN_01684	2.51e-150	yjbH	-	-	Q	-	-	-	Thioredoxin
NLIIHIGN_01685	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
NLIIHIGN_01686	1.25e-142	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
NLIIHIGN_01687	3.9e-40	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
NLIIHIGN_01688	5.67e-157	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
NLIIHIGN_01689	4.08e-88	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
NLIIHIGN_01690	1.31e-103	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
NLIIHIGN_01712	3.87e-112	-	-	-	-	-	-	-	-
NLIIHIGN_01714	1.39e-169	-	-	-	F	-	-	-	NUDIX domain
NLIIHIGN_01715	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NLIIHIGN_01716	3.53e-135	pncA	-	-	Q	-	-	-	Isochorismatase family
NLIIHIGN_01717	9.54e-266	-	-	-	O	-	-	-	ADP-ribosylglycohydrolase
NLIIHIGN_01718	0.0	-	-	-	F	ko:K03457	-	ko00000	Belongs to the purine-cytosine permease (2.A.39) family
NLIIHIGN_01719	1.72e-212	-	-	-	G	-	-	-	Belongs to the carbohydrate kinase PfkB family
NLIIHIGN_01720	1.07e-52	hxlR	-	-	K	-	-	-	regulation of RNA biosynthetic process
NLIIHIGN_01721	5.81e-295	-	-	-	EGP	-	-	-	MFS transporter, metabolite H symporter (MHS) family protein
NLIIHIGN_01722	1.29e-149	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
NLIIHIGN_01723	7.15e-148	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
NLIIHIGN_01724	1.44e-180	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
NLIIHIGN_01725	3.03e-129	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
NLIIHIGN_01726	6.01e-153	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
NLIIHIGN_01727	1.36e-286	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NLIIHIGN_01728	5.09e-186	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
NLIIHIGN_01730	1.01e-95	-	-	-	-	ko:K02248	-	ko00000,ko00002,ko02044	-
NLIIHIGN_01731	3.65e-60	-	-	-	-	-	-	-	-
NLIIHIGN_01732	3.65e-103	-	-	-	NU	ko:K02246	-	ko00000,ko00002,ko02044	general secretion pathway protein
NLIIHIGN_01733	6.31e-62	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	competence protein ComGC
NLIIHIGN_01734	2.95e-240	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
NLIIHIGN_01735	8.77e-237	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
NLIIHIGN_01736	1.22e-168	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
NLIIHIGN_01737	1.03e-181	-	-	-	-	-	-	-	-
NLIIHIGN_01738	1.7e-235	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
NLIIHIGN_01739	6.25e-272	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
NLIIHIGN_01740	2.93e-58	-	-	-	-	-	-	-	-
NLIIHIGN_01741	1.54e-71	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NLIIHIGN_01742	1.6e-190	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
NLIIHIGN_01743	1.4e-198	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
NLIIHIGN_01744	1.79e-100	ykuL	-	-	S	-	-	-	(CBS) domain
NLIIHIGN_01745	1.16e-124	-	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
NLIIHIGN_01746	5.35e-139	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NLIIHIGN_01747	3.41e-189	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
NLIIHIGN_01748	3.01e-126	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
NLIIHIGN_01749	2.86e-72	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
NLIIHIGN_01750	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
NLIIHIGN_01751	7.15e-122	cvpA	-	-	S	-	-	-	Colicin V production protein
NLIIHIGN_01752	3.75e-63	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
NLIIHIGN_01753	3.62e-100	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NLIIHIGN_01754	8.03e-58	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
NLIIHIGN_01755	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NLIIHIGN_01756	0.0	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
NLIIHIGN_01757	2.15e-234	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
NLIIHIGN_01758	1.86e-62	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
NLIIHIGN_01759	1.11e-260	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
NLIIHIGN_01760	9.97e-245	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
NLIIHIGN_01761	4.52e-133	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
NLIIHIGN_01762	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NLIIHIGN_01763	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NLIIHIGN_01764	2.29e-276	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
NLIIHIGN_01765	7.67e-252	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NLIIHIGN_01766	1.28e-295	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
NLIIHIGN_01767	1.16e-133	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NLIIHIGN_01768	1.45e-197	-	-	-	S	-	-	-	Helix-turn-helix domain
NLIIHIGN_01769	0.0	ymfH	-	-	S	-	-	-	Peptidase M16
NLIIHIGN_01770	3.68e-295	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
NLIIHIGN_01771	2.84e-205	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
NLIIHIGN_01772	1.45e-151	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01773	3.13e-141	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
NLIIHIGN_01774	1.69e-120	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
NLIIHIGN_01775	7.72e-195	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
NLIIHIGN_01776	8.33e-230	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
NLIIHIGN_01777	5.97e-157	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
NLIIHIGN_01778	4.34e-45	-	-	-	S	ko:K07473	-	ko00000,ko02048	RelB antitoxin
NLIIHIGN_01779	9.04e-60	-	-	-	-	-	-	-	-
NLIIHIGN_01781	1.66e-299	-	-	-	-	-	-	-	-
NLIIHIGN_01784	0.0	-	-	-	J	-	-	-	Elongation factor G, domain IV
NLIIHIGN_01785	6.57e-121	-	-	-	J	-	-	-	Aminoglycoside-2''-adenylyltransferase
NLIIHIGN_01786	2.85e-134	-	-	-	L	-	-	-	Integrase
NLIIHIGN_01787	0.0	-	-	-	S	-	-	-	SEC-C Motif Domain Protein
NLIIHIGN_01788	6.11e-68	-	-	-	-	-	-	-	-
NLIIHIGN_01789	2.03e-182	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NLIIHIGN_01790	3e-194	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
NLIIHIGN_01791	8.1e-153	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
NLIIHIGN_01792	6.12e-296	-	-	-	P	-	-	-	Chloride transporter, ClC family
NLIIHIGN_01793	0.0	agl	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 31 family
NLIIHIGN_01794	5.8e-149	-	-	-	I	-	-	-	Acid phosphatase homologues
NLIIHIGN_01795	2.63e-115	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
NLIIHIGN_01796	1.2e-105	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
NLIIHIGN_01797	1.38e-228	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
NLIIHIGN_01798	1.84e-174	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NLIIHIGN_01799	1.36e-136	-	-	-	-	-	-	-	-
NLIIHIGN_01800	7.73e-109	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
NLIIHIGN_01801	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
NLIIHIGN_01802	6.17e-192	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Serine aminopeptidase, S33
NLIIHIGN_01803	1.43e-47	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
NLIIHIGN_01804	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
NLIIHIGN_01806	9.88e-239	-	-	-	-	-	-	-	-
NLIIHIGN_01807	7.82e-37	-	-	-	-	-	-	-	-
NLIIHIGN_01808	3.16e-195	-	-	-	G	-	-	-	Belongs to the phosphoglycerate mutase family
NLIIHIGN_01809	7.72e-165	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
NLIIHIGN_01810	3.82e-133	-	-	-	D	ko:K04095	-	ko00000,ko03036	Fic/DOC family
NLIIHIGN_01811	5.2e-89	-	-	-	-	-	-	-	-
NLIIHIGN_01812	6.78e-284	XK27_00340	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
NLIIHIGN_01813	2.94e-206	XK27_00340	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
NLIIHIGN_01814	1.24e-136	-	-	-	L	-	-	-	nuclease
NLIIHIGN_01815	1.43e-252	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
NLIIHIGN_01816	6.92e-31	-	-	-	-	-	-	-	-
NLIIHIGN_01817	0.0	-	-	-	S	ko:K13730	ko05100,map05100	ko00000,ko00001	Uncharacterized protein conserved in bacteria (DUF2252)
NLIIHIGN_01818	8.63e-213	-	-	-	L	ko:K07496	-	ko00000	transposase, IS605 OrfB family
NLIIHIGN_01819	0.0	-	-	-	L	-	-	-	PFAM plasmid pRiA4b ORF-3 family protein
NLIIHIGN_01820	7.79e-263	adh	1.1.1.1	-	C	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Zinc-binding alcohol dehydrogenase family protein
NLIIHIGN_01821	1.66e-143	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NLIIHIGN_01822	2.04e-202	mleR	-	-	K	-	-	-	LysR family
NLIIHIGN_01823	2.55e-46	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
NLIIHIGN_01824	0.0	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
NLIIHIGN_01825	0.0	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
NLIIHIGN_01826	0.0	-	-	-	M	-	-	-	domain protein
NLIIHIGN_01827	0.0	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Poly(Glycerol-phosphate) alpha-glucosyltransferase
NLIIHIGN_01828	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
NLIIHIGN_01829	8.53e-95	-	-	-	-	-	-	-	-
NLIIHIGN_01830	7.43e-42	-	-	-	KV	ko:K01990	-	ko00000,ko00002,ko02000	of ABC transporters with duplicated ATPase domains
NLIIHIGN_01831	2.26e-28	-	-	-	-	-	-	-	-
NLIIHIGN_01832	1.77e-55	-	-	-	-	-	-	-	-
NLIIHIGN_01833	3.05e-281	-	-	-	-	-	-	-	-
NLIIHIGN_01835	1.88e-222	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair
NLIIHIGN_01836	0.0	-	-	-	S	ko:K18231,ko:K19349	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ATPases associated with a variety of cellular activities
NLIIHIGN_01837	9.04e-60	-	-	-	-	-	-	-	-
NLIIHIGN_01838	0.0	-	-	-	L	-	-	-	Transposase
NLIIHIGN_01839	2.26e-20	-	-	-	L	-	-	-	Transposase
NLIIHIGN_01841	1.31e-243	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
NLIIHIGN_01842	3.1e-289	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
NLIIHIGN_01843	2.51e-182	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NLIIHIGN_01844	0.0	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
NLIIHIGN_01845	0.0	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
NLIIHIGN_01846	5.76e-128	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
NLIIHIGN_01847	0.0	tdc	4.1.1.25	-	E	ko:K22330	ko00350,map00350	ko00000,ko00001,ko01000	Pyridoxal-dependent decarboxylase conserved domain
NLIIHIGN_01848	3.53e-297	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	Amino acid permease
NLIIHIGN_01849	2.87e-247	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter NhaC
NLIIHIGN_01850	2.76e-277	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NLIIHIGN_01851	5.67e-313	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
NLIIHIGN_01852	1.02e-51	XK27_08630	-	-	T	ko:K07166	-	ko00000	Belongs to the UPF0237 family
NLIIHIGN_01853	1.08e-221	yvgN	-	-	C	-	-	-	Aldo keto reductase
NLIIHIGN_01854	2.08e-208	rlrB	-	-	K	-	-	-	LysR substrate binding domain protein
NLIIHIGN_01855	7.72e-114	-	-	-	C	-	-	-	Flavodoxin
NLIIHIGN_01856	9.07e-106	-	-	-	S	-	-	-	Cupin domain
NLIIHIGN_01857	1.35e-97	-	-	-	S	-	-	-	UPF0756 membrane protein
NLIIHIGN_01858	5.01e-310	-	-	-	U	-	-	-	Belongs to the major facilitator superfamily
NLIIHIGN_01859	1.68e-98	atkY	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Copper transport repressor CopY TcrY
NLIIHIGN_01860	6.22e-153	-	-	-	S	-	-	-	Uncharacterised protein family (UPF0236)
NLIIHIGN_01861	8.3e-134	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
NLIIHIGN_01862	2.79e-107	-	-	-	-	-	-	-	-
NLIIHIGN_01863	9.99e-44	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
NLIIHIGN_01864	2.71e-235	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic
NLIIHIGN_01865	4.37e-39	-	-	-	-	-	-	-	-
NLIIHIGN_01866	2.43e-248	-	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
NLIIHIGN_01868	5.28e-76	-	-	-	-	-	-	-	-
NLIIHIGN_01869	1.73e-270	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
NLIIHIGN_01870	2.31e-281	yojA	-	-	EG	ko:K03299	-	ko00000,ko02000	GntP family permease
NLIIHIGN_01871	2.35e-91	-	-	-	KT	ko:K02647	-	ko00000,ko03000	Putative sugar diacid recognition
NLIIHIGN_01872	1.56e-255	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NLIIHIGN_01873	1.84e-282	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
NLIIHIGN_01874	9.39e-183	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
NLIIHIGN_01875	5.62e-224	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NLIIHIGN_01876	4.19e-286	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
NLIIHIGN_01877	1.2e-114	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
NLIIHIGN_01878	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
NLIIHIGN_01879	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
NLIIHIGN_01880	1.53e-241	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NLIIHIGN_01881	1.04e-223	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NLIIHIGN_01882	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
NLIIHIGN_01883	4.38e-114	-	-	-	S	-	-	-	repeat protein
NLIIHIGN_01884	1.99e-159	pgm6	-	-	G	-	-	-	phosphoglycerate mutase
NLIIHIGN_01885	4.35e-286	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
NLIIHIGN_01886	5.58e-76	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
NLIIHIGN_01887	9.43e-280	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
NLIIHIGN_01888	3.4e-162	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NLIIHIGN_01889	1.54e-33	-	-	-	-	-	-	-	-
NLIIHIGN_01890	2.48e-129	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
NLIIHIGN_01891	5.69e-44	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
NLIIHIGN_01892	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NLIIHIGN_01893	6.11e-108	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA domain protein
NLIIHIGN_01894	1.84e-190	ylmH	-	-	S	-	-	-	S4 domain protein
NLIIHIGN_01895	1.11e-54	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	YGGT family
NLIIHIGN_01896	1.57e-92	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
NLIIHIGN_01897	6.52e-289	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NLIIHIGN_01898	0.0	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
NLIIHIGN_01899	3.03e-195	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
NLIIHIGN_01900	2.16e-262	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NLIIHIGN_01901	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NLIIHIGN_01902	5.44e-230	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NLIIHIGN_01903	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
NLIIHIGN_01904	5.99e-74	ftsL	-	-	D	-	-	-	Cell division protein FtsL
NLIIHIGN_01905	4.61e-224	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
NLIIHIGN_01906	1.5e-101	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
NLIIHIGN_01907	1.6e-77	-	-	-	-	-	-	-	-
NLIIHIGN_01908	4.47e-16	-	-	-	S	-	-	-	Protein of unknown function (DUF4044)
NLIIHIGN_01909	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
NLIIHIGN_01910	2.64e-124	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
NLIIHIGN_01911	3.61e-209	rrmA	2.1.1.187	-	H	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase
NLIIHIGN_01912	2.79e-253	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
NLIIHIGN_01913	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
NLIIHIGN_01914	3.22e-269	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
NLIIHIGN_01915	0.0	-	-	-	G	ko:K16211	-	ko00000,ko02000	Major Facilitator
NLIIHIGN_01916	2.07e-236	cytR	-	-	K	ko:K02529,ko:K03604	-	ko00000,ko03000	Transcriptional regulator, LacI family
NLIIHIGN_01917	7.21e-39	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
NLIIHIGN_01918	1.01e-129	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
NLIIHIGN_01919	1.75e-276	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
NLIIHIGN_01920	9.84e-183	yqeM	-	-	Q	-	-	-	Methyltransferase
NLIIHIGN_01921	2.3e-80	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
NLIIHIGN_01922	6.21e-147	yqeK	-	-	H	-	-	-	Hydrolase, HD family
NLIIHIGN_01923	4.36e-161	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NLIIHIGN_01924	5.4e-63	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
NLIIHIGN_01925	5.44e-279	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
NLIIHIGN_01926	1.91e-125	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
NLIIHIGN_01927	1.52e-209	-	-	-	S	-	-	-	Tetratricopeptide repeat
NLIIHIGN_01928	4.94e-288	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NLIIHIGN_01929	5.54e-303	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
NLIIHIGN_01930	1.02e-297	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NLIIHIGN_01931	2.01e-139	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
NLIIHIGN_01932	1.11e-78	-	-	-	S	-	-	-	mazG nucleotide pyrophosphohydrolase
NLIIHIGN_01933	5.97e-265	thiP	-	-	U	-	-	-	Belongs to the purine-cytosine permease (2.A.39) family
NLIIHIGN_01934	4.89e-122	-	-	-	K	-	-	-	PFAM GCN5-related N-acetyltransferase
NLIIHIGN_01935	3.34e-84	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
NLIIHIGN_01936	2.51e-110	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
NLIIHIGN_01937	5.69e-105	-	-	-	-	-	-	-	-
NLIIHIGN_01938	3.05e-167	-	-	-	M	-	-	-	Lysin motif
NLIIHIGN_01939	6.71e-249	-	-	-	EGP	-	-	-	Major Facilitator
NLIIHIGN_01940	1.05e-273	-	-	-	EGP	-	-	-	Transporter, major facilitator family protein
NLIIHIGN_01941	0.0	gtfA	2.4.1.7	GH13	G	ko:K00690	ko00500,map00500	ko00000,ko00001,ko01000	Sucrose glucosyltransferase
NLIIHIGN_01942	1.95e-178	-	-	-	V	-	-	-	Beta-lactamase enzyme family
NLIIHIGN_01943	1.73e-288	dacA	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
NLIIHIGN_01944	5.36e-97	-	-	-	-	-	-	-	-
NLIIHIGN_01945	2.13e-129	npp	-	-	S	-	-	-	type I phosphodiesterase nucleotide pyrophosphatase
NLIIHIGN_01946	9.08e-317	-	-	-	E	ko:K03294	-	ko00000	amino acid
NLIIHIGN_01947	1.46e-236	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NLIIHIGN_01949	2.33e-39	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01950	9.33e-06	-	-	-	S	-	-	-	Protein of unknown function (DUF3278)
NLIIHIGN_01951	2.61e-283	-	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
NLIIHIGN_01953	0.0	-	2.3.1.82, 2.7.1.190	-	F	ko:K19883	-	ko00000,ko01000,ko01504	Involved in resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region. The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides
NLIIHIGN_01959	6.81e-138	-	-	-	S	-	-	-	Protein of unknown function (DUF3102)
NLIIHIGN_01960	1.33e-11	-	-	-	-	-	-	-	-
NLIIHIGN_01961	2.21e-66	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_01965	7.99e-129	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01967	9.17e-59	-	-	-	-	-	-	-	-
NLIIHIGN_01968	7.19e-280	aspC	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
NLIIHIGN_01969	5.03e-166	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
NLIIHIGN_01970	1.52e-200	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NLIIHIGN_01971	2.15e-299	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
NLIIHIGN_01972	7.28e-117	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
NLIIHIGN_01973	4.69e-239	ldhA	1.1.1.28	-	C	ko:K03778,ko:K18347	ko00620,ko01120,ko01502,ko02020,map00620,map01120,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01504	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLIIHIGN_01974	0.0	ycfI	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
NLIIHIGN_01975	0.0	yfiC	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
NLIIHIGN_01977	5.1e-45	-	-	-	S	ko:K07341	-	ko00000,ko02048	Fic/DOC family
NLIIHIGN_01978	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NLIIHIGN_01979	7.58e-165	-	-	-	F	-	-	-	NUDIX domain
NLIIHIGN_01980	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NLIIHIGN_01981	1.35e-134	pncA	-	-	Q	-	-	-	Isochorismatase family
NLIIHIGN_01982	0.0	-	-	-	L	-	-	-	Recombinase
NLIIHIGN_01983	0.0	-	-	-	L	-	-	-	Recombinase zinc beta ribbon domain
NLIIHIGN_01984	4.34e-41	-	-	-	-	-	-	-	-
NLIIHIGN_01985	2.37e-165	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
NLIIHIGN_01986	2.02e-88	-	-	-	S	-	-	-	Bacteriophage holin family
NLIIHIGN_01987	8.4e-85	-	-	-	S	-	-	-	Phage head-tail joining protein
NLIIHIGN_01988	2.96e-55	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
NLIIHIGN_01989	3.07e-264	-	-	-	S	-	-	-	Phage capsid family
NLIIHIGN_01990	2.48e-151	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S14 family
NLIIHIGN_01991	1.31e-307	-	-	-	S	-	-	-	Phage portal protein
NLIIHIGN_01992	0.0	-	-	-	S	-	-	-	overlaps another CDS with the same product name
NLIIHIGN_01993	2.05e-42	-	-	-	S	-	-	-	Domain of unknown function (DUF5049)
NLIIHIGN_01994	1.85e-149	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
NLIIHIGN_01995	7.85e-307	-	-	-	KL	-	-	-	DNA methylase
NLIIHIGN_01996	1.97e-129	-	-	-	-	-	-	-	-
NLIIHIGN_01997	2.99e-95	-	-	-	V	ko:K07451	-	ko00000,ko01000,ko02048	HNH nucleases
NLIIHIGN_01998	1.45e-112	-	-	-	-	-	-	-	-
NLIIHIGN_01999	3.84e-313	-	-	-	L	-	-	-	SNF2 family N-terminal domain
NLIIHIGN_02000	1.45e-60	-	-	-	S	-	-	-	VRR_NUC
NLIIHIGN_02001	0.0	-	-	-	S	ko:K06919	-	ko00000	Phage plasmid primase, P4
NLIIHIGN_02002	2.4e-80	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
NLIIHIGN_02003	0.0	-	2.7.7.7	-	L	ko:K02334	-	ko00000,ko01000	DNA polymerase
NLIIHIGN_02004	2.74e-125	-	-	-	S	-	-	-	Protein of unknown function (DUF2815)
NLIIHIGN_02005	2.35e-266	-	-	-	L	-	-	-	Protein of unknown function (DUF2800)
NLIIHIGN_02006	2.45e-60	-	-	-	-	-	-	-	-
NLIIHIGN_02007	1.86e-33	-	-	-	-	-	-	-	-
NLIIHIGN_02009	1.95e-293	-	-	-	-	-	-	-	-
NLIIHIGN_02010	3.52e-48	-	-	-	-	-	-	-	-
NLIIHIGN_02011	0.0	-	-	-	-	-	-	-	-
NLIIHIGN_02012	1.63e-52	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
NLIIHIGN_02013	0.0	mod	2.1.1.72	-	L	ko:K00571,ko:K07316	-	ko00000,ko01000,ko02048	DNA methylase
NLIIHIGN_02014	0.0	res	3.1.21.5	-	L	ko:K01156	-	ko00000,ko01000,ko02048	Type III restriction enzyme, res subunit
NLIIHIGN_02015	2.61e-298	-	-	-	K	-	-	-	DNA binding
NLIIHIGN_02016	0.0	-	-	-	L	-	-	-	helicase activity
NLIIHIGN_02018	2.79e-61	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
NLIIHIGN_02019	0.0	-	-	-	L	-	-	-	Helicase C-terminal domain protein
NLIIHIGN_02020	6.5e-16	-	-	-	-	-	-	-	-
NLIIHIGN_02022	6.27e-217	-	-	-	L	-	-	-	Plasmid pRiA4b ORF-3-like protein
NLIIHIGN_02024	9.77e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
NLIIHIGN_02025	1.46e-96	-	-	-	K	-	-	-	LytTr DNA-binding domain
NLIIHIGN_02026	2.77e-219	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NLIIHIGN_02027	2.64e-242	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NLIIHIGN_02028	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
NLIIHIGN_02029	6.85e-115	-	-	-	-	-	-	-	-
NLIIHIGN_02030	2.98e-64	gcsH2	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	glycine cleavage
NLIIHIGN_02031	4.7e-282	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
NLIIHIGN_02032	7.96e-45	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
NLIIHIGN_02033	2.57e-227	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
NLIIHIGN_02034	7.7e-311	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NLIIHIGN_02035	1.76e-45	ywzB	-	-	S	-	-	-	Protein of unknown function (DUF1146)
NLIIHIGN_02036	7.97e-82	-	-	-	S	-	-	-	Domain of unknown function (DUF4828)
NLIIHIGN_02037	1.31e-245	mocA	-	-	S	-	-	-	Oxidoreductase
NLIIHIGN_02038	2.32e-298	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
NLIIHIGN_02040	8.5e-266	mnaA	5.1.3.14	-	G	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
NLIIHIGN_02041	4.96e-73	-	-	-	-	-	-	-	-
NLIIHIGN_02042	2.4e-230	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
NLIIHIGN_02043	3e-274	-	1.5.1.36	-	S	ko:K19784,ko:K22393,ko:K22394	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	reductase
NLIIHIGN_02044	6e-132	-	1.5.1.36	-	S	ko:K19784,ko:K22393	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	reductase
NLIIHIGN_02046	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NLIIHIGN_02047	3.5e-112	-	-	-	S	ko:K19055	-	ko00000,ko01000,ko03016	Aminoacyl-tRNA editing domain
NLIIHIGN_02048	0.0	-	-	-	E	-	-	-	amino acid
NLIIHIGN_02049	0.0	ydaO	-	-	E	-	-	-	amino acid
NLIIHIGN_02050	2.63e-53	-	-	-	-	-	-	-	-
NLIIHIGN_02052	9.34e-92	-	-	-	-	-	-	-	-
NLIIHIGN_02053	5.16e-24	-	-	-	-	-	-	-	-
NLIIHIGN_02054	2.64e-98	-	-	-	E	-	-	-	IrrE N-terminal-like domain
NLIIHIGN_02055	2.01e-62	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
NLIIHIGN_02056	3.22e-22	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
NLIIHIGN_02058	5.93e-102	-	-	-	S	-	-	-	MobA/MobL family
NLIIHIGN_02061	2.01e-77	-	-	-	S	-	-	-	Initiator Replication protein
NLIIHIGN_02062	5.84e-108	-	-	-	S	-	-	-	Fic/DOC family
NLIIHIGN_02063	5.57e-80	-	-	-	V	-	-	-	HNH endonuclease
NLIIHIGN_02066	2.58e-283	-	-	-	L	-	-	-	Domain of unknown function (DUF4368)
NLIIHIGN_02067	6.27e-216	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
NLIIHIGN_02068	1.46e-203	rssA	-	-	S	-	-	-	Phospholipase, patatin family
NLIIHIGN_02069	1.15e-152	-	-	-	L	-	-	-	Integrase
NLIIHIGN_02070	3.97e-198	-	-	-	EG	-	-	-	EamA-like transporter family
NLIIHIGN_02071	9.39e-256	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
NLIIHIGN_02072	2.72e-56	-	-	-	CQ	-	-	-	BMC
NLIIHIGN_02073	3.41e-170	pduB	-	-	E	-	-	-	BMC
NLIIHIGN_02074	0.0	pduC	4.2.1.28	-	Q	ko:K01699	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase large subunit
NLIIHIGN_02075	7.71e-166	pduD	4.2.1.28	-	Q	ko:K13919	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase medium subunit
NLIIHIGN_02076	1.1e-106	pduE	4.2.1.28	-	Q	ko:K13920	ko00640,map00640	ko00000,ko00001,ko01000	Dehydratase small subunit
NLIIHIGN_02077	0.0	pduG	-	-	D	-	-	-	Diol dehydratase reactivase ATPase-like domain
NLIIHIGN_02078	8.32e-79	pduH	-	-	S	-	-	-	Dehydratase medium subunit
NLIIHIGN_02079	3.28e-112	-	-	-	CQ	-	-	-	BMC
NLIIHIGN_02080	4.11e-57	pduA_2	-	-	CQ	ko:K04027	-	ko00000	BMC
NLIIHIGN_02081	1.02e-150	pduL	2.3.1.222	-	Q	ko:K13923	ko00640,map00640	ko00000,ko00001,ko01000	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate
NLIIHIGN_02082	3.9e-116	-	-	-	S	-	-	-	Putative propanediol utilisation
NLIIHIGN_02083	1.96e-55	pduN	-	-	CQ	ko:K04028	-	ko00000	Ethanolamine utilisation protein EutN/carboxysome
NLIIHIGN_02084	1.26e-137	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
NLIIHIGN_02085	1.01e-104	pduO	-	-	S	-	-	-	Haem-degrading
NLIIHIGN_02086	0.0	pduP	1.2.1.87	-	C	ko:K13922	ko00640,map00640	ko00000,ko00001,ko01000	Aldehyde dehydrogenase family
NLIIHIGN_02087	3.1e-268	pduQ	-	-	C	ko:K13921	ko00640,map00640	ko00000,ko00001	Iron-containing alcohol dehydrogenase
NLIIHIGN_02088	1.3e-282	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NLIIHIGN_02089	9.52e-74	-	-	-	E	ko:K04031	-	ko00000	BMC
NLIIHIGN_02090	2.32e-190	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Pfam:Y_phosphatase3C
NLIIHIGN_02091	6.68e-156	pgm1	-	-	G	-	-	-	phosphoglycerate mutase
NLIIHIGN_02092	1.64e-110	-	-	-	P	-	-	-	Cadmium resistance transporter
NLIIHIGN_02093	2.69e-95	eutP	-	-	E	ko:K04029	-	ko00000	Ethanolamine utilisation - propanediol utilisation
NLIIHIGN_02094	2.54e-101	ykuP	-	-	C	ko:K03839	-	ko00000	Flavodoxin
NLIIHIGN_02095	1.99e-199	nqo1	-	-	S	ko:K19784	-	ko00000	NADPH-dependent FMN reductase
NLIIHIGN_02096	6.54e-132	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobalamin adenosyltransferase
NLIIHIGN_02097	7.26e-266	cobD	4.1.1.81	-	E	ko:K04720	ko00860,map00860	ko00000,ko00001,ko01000	Aminotransferase class I and II
NLIIHIGN_02098	0.0	cbiA	6.3.5.11, 6.3.5.9	-	F	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
NLIIHIGN_02099	3.27e-229	cobD	6.3.1.10	-	H	ko:K02227	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NLIIHIGN_02100	6.88e-160	cbiC	5.4.99.60, 5.4.99.61	-	H	ko:K06042	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Precorrin-8X methylmutase
NLIIHIGN_02101	6.31e-273	cbiD	2.1.1.195	-	H	ko:K02188	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NLIIHIGN_02102	4.92e-142	cbiE	2.1.1.289	-	H	ko:K03399	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
NLIIHIGN_02103	4.79e-123	cbiT	2.1.1.196	-	H	ko:K02191	ko00860,map00860	ko00000,ko00001,ko01000	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
NLIIHIGN_02104	1.13e-171	cbiF	2.1.1.133, 2.1.1.271	-	H	ko:K05936	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
NLIIHIGN_02105	8.21e-246	cbiG	3.7.1.12	-	H	ko:K02189	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Cobalamin synthesis G C-terminus
NLIIHIGN_02106	1.06e-170	cbiH	2.1.1.131	-	H	ko:K05934	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
NLIIHIGN_02107	3e-171	cobK	1.3.1.106, 1.3.1.54	-	H	ko:K05895	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Precorrin-6x reductase CbiJ/CobK
NLIIHIGN_02108	0.0	cobA	2.1.1.107, 4.2.1.75	-	H	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
NLIIHIGN_02109	7.18e-187	cbiK	4.99.1.3	-	H	ko:K02190	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Cobalt chelatase (CbiK)
NLIIHIGN_02110	3.64e-160	cbiL	2.1.1.130, 2.1.1.151	-	H	ko:K03394	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko01000	Tetrapyrrole (Corrin/Porphyrin) Methylases
NLIIHIGN_02111	4.44e-171	cbiM	-	-	P	ko:K02007	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NLIIHIGN_02112	7.35e-70	cbiN	-	-	P	ko:K02009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NLIIHIGN_02113	3.94e-149	cbiQ	-	-	P	ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
NLIIHIGN_02114	5.9e-190	cbiO	-	-	P	ko:K02006	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	part of an ABC transporter complex. Responsible for energy coupling to the transport system
NLIIHIGN_02115	0.0	cobQ	6.3.5.10	-	H	ko:K02232	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
NLIIHIGN_02116	6.68e-103	cysG	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Putative NAD(P)-binding
NLIIHIGN_02117	3.96e-293	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NLIIHIGN_02118	1.78e-210	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
NLIIHIGN_02119	1.56e-229	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Delta-aminolevulinic acid dehydratase
NLIIHIGN_02120	0.0	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
NLIIHIGN_02121	9.9e-131	cobU	2.7.1.156, 2.7.7.62	-	H	ko:K02231	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobinamide kinase / cobinamide phosphate guanyltransferase
NLIIHIGN_02122	5.84e-174	cobS	2.7.8.26	-	H	ko:K02233	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NLIIHIGN_02123	3.23e-145	cobC	3.1.3.73	-	G	ko:K02226	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the phosphoglycerate mutase family
NLIIHIGN_02124	3.41e-169	-	-	-	H	-	-	-	Uroporphyrinogen-III synthase
NLIIHIGN_02125	3.77e-246	cobT	2.4.2.21	-	F	ko:K00768	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
NLIIHIGN_02126	2.94e-80	-	-	-	S	-	-	-	Domain of unknown function (DUF4430)
NLIIHIGN_02127	4.13e-116	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	ECF transporter, substrate-specific component