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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
HMBIOMIE_00022	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMBIOMIE_00023	2.96e-265	glgC	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMBIOMIE_00024	1.58e-239	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Glucose-1-phosphate adenylyltransferase, GlgD subunit
HMBIOMIE_00025	0.0	glgA	2.4.1.21	GT5	G	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000,ko01003	Synthesizes alpha-1,4-glucan chains using ADP-glucose
HMBIOMIE_00026	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HMBIOMIE_00027	1.97e-101	ytaB	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	membrane
HMBIOMIE_00028	9.43e-263	cotI	-	-	S	ko:K06331	-	ko00000	Spore coat protein
HMBIOMIE_00029	1.75e-276	cotSA	-	-	M	ko:K06338	-	ko00000	Glycosyl transferases group 1
HMBIOMIE_00030	1.7e-263	cotS	-	-	S	ko:K06337	-	ko00000	Seems to be required for the assembly of the CotSA protein in spores
HMBIOMIE_00032	3.7e-300	-	-	-	M	ko:K06338	-	ko00000	Glycosyltransferase Family 4
HMBIOMIE_00033	7.74e-231	ytcB	-	-	M	-	-	-	NAD-dependent epimerase dehydratase
HMBIOMIE_00034	2.03e-310	ytcA	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMBIOMIE_00035	1.7e-196	ytdA	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
HMBIOMIE_00036	8.68e-169	yteA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
HMBIOMIE_00037	0.0	menF	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
HMBIOMIE_00038	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMBIOMIE_00039	5.09e-199	menH	4.2.99.20	-	S	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
HMBIOMIE_00040	3.45e-200	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HMBIOMIE_00041	0.0	menE	6.2.1.26	-	H	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
HMBIOMIE_00042	7.07e-273	menC	4.2.1.113	-	H	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HMBIOMIE_00043	1.13e-218	troA	-	-	P	ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HMBIOMIE_00044	1.83e-180	mntB	3.6.3.35	-	P	ko:K02074,ko:K09820,ko:K11710,ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HMBIOMIE_00045	1.64e-299	mntC	-	-	P	ko:K11705,ko:K11708,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HMBIOMIE_00046	9.65e-194	mntD	-	-	P	ko:K11709,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
HMBIOMIE_00047	2.43e-34	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1540)
HMBIOMIE_00048	2.96e-241	ythB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
HMBIOMIE_00049	1.03e-315	ythA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
HMBIOMIE_00050	5.02e-56	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
HMBIOMIE_00051	8.96e-134	ytiB	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
HMBIOMIE_00052	8.36e-113	luxS	4.4.1.21	-	T	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HMBIOMIE_00053	8.26e-96	ytkA	-	-	S	-	-	-	YtkA-like
HMBIOMIE_00055	1.8e-99	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
HMBIOMIE_00056	1.59e-81	ytkC	-	-	S	-	-	-	Bacteriophage holin family
HMBIOMIE_00057	4.47e-113	ytkD	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
HMBIOMIE_00058	1.32e-183	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HMBIOMIE_00059	1.5e-184	ytlC	3.6.3.36	-	P	ko:K02049,ko:K10831,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HMBIOMIE_00060	2.77e-242	ytlA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
HMBIOMIE_00061	6.67e-191	ytmA	-	-	E	-	-	-	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
HMBIOMIE_00062	2.85e-52	ytmB	-	-	S	-	-	-	Protein of unknown function (DUF2584)
HMBIOMIE_00063	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HMBIOMIE_00064	2.26e-286	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMBIOMIE_00065	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HMBIOMIE_00066	0.0	ytnA	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_00067	8.35e-88	ytoA	-	-	S	-	-	-	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HMBIOMIE_00068	2.33e-192	ytpA	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
HMBIOMIE_00069	4.81e-276	ytpB	4.2.3.130	-	S	ko:K16188	-	ko00000,ko01000	Tetraprenyl-beta-curcumene synthase
HMBIOMIE_00070	6.76e-137	ytqB	-	-	J	-	-	-	Putative rRNA methylase
HMBIOMIE_00071	4.06e-245	ytqA	-	-	S	ko:K07139	-	ko00000	Fe-S oxidoreductase
HMBIOMIE_00072	1.27e-55	ytzC	-	-	S	-	-	-	Protein of unknown function (DUF2524)
HMBIOMIE_00074	2.68e-87	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	GntR family transcriptional regulator
HMBIOMIE_00075	1.03e-207	ytrB	-	-	P	ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_00076	3.35e-222	-	-	-	P	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
HMBIOMIE_00077	1.07e-189	-	-	-	-	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	-
HMBIOMIE_00078	1.02e-163	ytrE	-	-	V	ko:K16920	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_00079	5.92e-298	ytrF	-	-	V	ko:K02004,ko:K16918	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
HMBIOMIE_00080	1.77e-167	graR	-	-	T	ko:K11630,ko:K19078	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01504,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_00081	1.58e-239	bceS	2.7.13.3	-	T	ko:K11629,ko:K19077	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	His Kinase A (phosphoacceptor) domain
HMBIOMIE_00082	3.83e-179	bceA	-	-	V	ko:K02003,ko:K11631,ko:K19079	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_00083	0.0	bceB	-	-	V	ko:K11632,ko:K19080	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter (permease)
HMBIOMIE_00084	2.02e-78	yttA	-	-	S	-	-	-	Pfam Transposase IS66
HMBIOMIE_00085	2.98e-269	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
HMBIOMIE_00086	6.61e-184	pfyP	-	-	T	-	-	-	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
HMBIOMIE_00087	3.63e-72	ytvB	-	-	S	-	-	-	Protein of unknown function (DUF4257)
HMBIOMIE_00088	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
HMBIOMIE_00089	1.22e-68	ytwF	-	-	P	-	-	-	Sulfurtransferase
HMBIOMIE_00090	0.0	melA	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
HMBIOMIE_00091	1.32e-186	amyC	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
HMBIOMIE_00092	2.86e-215	amyD	-	-	P	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_00093	4.68e-315	msmE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HMBIOMIE_00094	1.12e-244	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_00095	1.43e-222	-	-	-	S	-	-	-	Acetyl xylan esterase (AXE1)
HMBIOMIE_00096	4.04e-182	bioW	6.2.1.14	-	H	ko:K01906	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HMBIOMIE_00097	0.0	bioA	2.6.1.105, 2.6.1.62	-	H	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
HMBIOMIE_00098	3.73e-284	bioF	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HMBIOMIE_00099	5.04e-164	bioD	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMBIOMIE_00100	4.57e-244	bioB	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMBIOMIE_00101	2.64e-287	bioI	1.14.14.46, 1.14.15.13	-	C	ko:K15468,ko:K16593,ko:K17474	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
HMBIOMIE_00102	2.21e-178	ytbQ	1.1.1.203, 1.1.1.388	-	GM	ko:K18981,ko:K19243	ko00030,ko00053,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00053,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	NAD dependent epimerase/dehydratase family
HMBIOMIE_00103	6.19e-193	ytcP	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
HMBIOMIE_00104	0.0	-	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1653 ABC-type sugar transport system, periplasmic component
HMBIOMIE_00105	0.0	ytdP	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00106	2.27e-221	lplB13	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
HMBIOMIE_00107	2.23e-286	yteR	3.2.1.172	GH105	G	ko:K15532	-	ko00000,ko01000	unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
HMBIOMIE_00108	5.81e-95	yteS	-	-	G	-	-	-	transport
HMBIOMIE_00109	0.0	yteT	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
HMBIOMIE_00110	1.97e-152	yteU	-	-	S	-	-	-	Integral membrane protein
HMBIOMIE_00111	2.14e-36	yteV	-	-	S	-	-	-	Sporulation protein Cse60
HMBIOMIE_00112	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
HMBIOMIE_00113	6.99e-294	ytfP	-	-	S	ko:K07007	-	ko00000	HI0933-like protein
HMBIOMIE_00114	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_00115	9.04e-171	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HMBIOMIE_00116	4.46e-46	ytzE	-	-	K	-	-	-	COG1349 Transcriptional regulators of sugar metabolism
HMBIOMIE_00117	2.4e-169	ythP	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HMBIOMIE_00118	8.45e-263	ythQ	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	Bacterial ABC transporter protein EcsB
HMBIOMIE_00119	1.73e-288	pbuO	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HMBIOMIE_00120	0.0	ytjP	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Dipeptidase
HMBIOMIE_00121	3e-221	ytkP	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HMBIOMIE_00122	7.71e-133	ytlP	3.1.4.58	-	J	ko:K01975	-	ko00000,ko01000,ko03016	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HMBIOMIE_00123	4.92e-212	ytlQ	-	-	-	-	-	-	-
HMBIOMIE_00124	2.22e-231	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HMBIOMIE_00125	0.0	amyX	3.2.1.41	CBM48,GH13	G	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HMBIOMIE_00126	3.02e-192	ytmP	-	-	M	-	-	-	Phosphotransferase
HMBIOMIE_00127	9.51e-61	ytzH	-	-	S	-	-	-	YtzH-like protein
HMBIOMIE_00128	7.53e-157	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HMBIOMIE_00129	2.16e-193	ytnP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
HMBIOMIE_00130	0.0	malS	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
HMBIOMIE_00131	4.06e-68	ytzB	-	-	S	-	-	-	small secreted protein
HMBIOMIE_00132	2.24e-262	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
HMBIOMIE_00133	7.02e-103	ytoQ	-	-	S	-	-	-	Nucleoside 2-deoxyribosyltransferase YtoQ
HMBIOMIE_00134	3.17e-75	ytpP	-	-	CO	-	-	-	Thioredoxin
HMBIOMIE_00135	1.02e-191	ytpQ	-	-	S	-	-	-	Belongs to the UPF0354 family
HMBIOMIE_00136	1.78e-140	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMBIOMIE_00137	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HMBIOMIE_00138	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
HMBIOMIE_00139	1.67e-63	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HMBIOMIE_00140	3.17e-30	ytxH	-	-	S	-	-	-	COG4980 Gas vesicle protein
HMBIOMIE_00141	1.9e-72	ytxJ	-	-	O	-	-	-	Protein of unknown function (DUF2847)
HMBIOMIE_00142	7.64e-250	aroA	2.5.1.54, 5.4.99.5	-	E	ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
HMBIOMIE_00143	4.16e-235	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
HMBIOMIE_00144	1.18e-187	motP	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
HMBIOMIE_00145	1.6e-161	ytxE	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
HMBIOMIE_00146	6.51e-293	acuC	-	-	BQ	ko:K04768	-	ko00000	histone deacetylase
HMBIOMIE_00147	6.16e-152	acuB	-	-	S	ko:K04767	-	ko00000	Domain in cystathionine beta-synthase and other proteins.
HMBIOMIE_00148	2.43e-156	acuA	-	-	K	ko:K04766	-	ko00000,ko01000	Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
HMBIOMIE_00149	0.0	acsA	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HMBIOMIE_00150	6.47e-304	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMBIOMIE_00152	2.01e-141	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMBIOMIE_00153	0.0	ytrP	-	-	T	-	-	-	COG2199 FOG GGDEF domain
HMBIOMIE_00154	1.95e-114	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
HMBIOMIE_00155	1.2e-141	yttP	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00156	3.73e-198	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	COG1387 Histidinol phosphatase and related hydrolases of the PHP family
HMBIOMIE_00157	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HMBIOMIE_00158	1.17e-304	braB	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HMBIOMIE_00159	5.54e-266	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
HMBIOMIE_00160	1.04e-287	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMBIOMIE_00161	2.12e-40	-	-	-	S	ko:K06418,ko:K06419,ko:K06420	-	ko00000	spore protein
HMBIOMIE_00162	0.0	ytcI	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
HMBIOMIE_00163	0.0	ytcJ	-	-	S	-	-	-	amidohydrolase
HMBIOMIE_00164	9.78e-189	nadK2	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMBIOMIE_00165	9.73e-230	sppA	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	signal peptide peptidase SppA
HMBIOMIE_00166	4.08e-112	yteJ	-	-	S	-	-	-	RDD family
HMBIOMIE_00167	1.68e-148	ytfI	-	-	S	-	-	-	Protein of unknown function (DUF2953)
HMBIOMIE_00168	1.06e-94	ytfJ	-	-	S	-	-	-	Sporulation protein YtfJ
HMBIOMIE_00169	1.93e-116	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMBIOMIE_00170	3.78e-224	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
HMBIOMIE_00171	4.69e-281	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMBIOMIE_00172	8.14e-115	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
HMBIOMIE_00173	1.06e-297	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
HMBIOMIE_00174	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
HMBIOMIE_00176	1.98e-182	ytkK	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_00177	1.91e-166	ytkL	-	-	S	-	-	-	Belongs to the UPF0173 family
HMBIOMIE_00178	4.99e-223	ytlI	-	-	K	ko:K21960	-	ko00000,ko03000	LysR substrate binding domain
HMBIOMIE_00179	8.39e-130	ytmI	-	-	K	ko:K00680	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HMBIOMIE_00180	3.18e-195	-	-	-	ET	ko:K16956,ko:K16957,ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
HMBIOMIE_00181	1.9e-190	tcyK	-	-	M	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
HMBIOMIE_00182	3.9e-156	ytmL	-	-	P	ko:K16958,ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_00183	7.89e-154	-	-	-	U	ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_00184	6.61e-183	tcyN	-	-	E	ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
HMBIOMIE_00185	1.39e-233	ytmO	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_00186	2.07e-60	ytnI	-	-	O	-	-	-	COG0695 Glutaredoxin and related proteins
HMBIOMIE_00187	0.0	ytnJ	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_00188	1.69e-166	-	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin kinase
HMBIOMIE_00189	3.05e-299	hipO2	-	-	E	ko:K01436,ko:K21613	-	ko00000,ko01000,ko01002	hydrolase activity
HMBIOMIE_00190	2.24e-206	ytnM	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HMBIOMIE_00191	1.13e-308	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
HMBIOMIE_00192	2.15e-63	ytpI	-	-	S	-	-	-	YtpI-like protein
HMBIOMIE_00193	1.24e-230	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	COG0618 Exopolyphosphatase-related proteins
HMBIOMIE_00194	1.15e-39	-	-	-	-	-	-	-	-
HMBIOMIE_00195	2.08e-111	ytrI	-	-	-	-	-	-	-
HMBIOMIE_00196	2.45e-75	ytrH	-	-	S	-	-	-	Sporulation protein YtrH
HMBIOMIE_00197	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
HMBIOMIE_00198	8.53e-287	ytsJ	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
HMBIOMIE_00199	1.25e-207	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMBIOMIE_00200	9.82e-234	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
HMBIOMIE_00201	1.62e-229	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HMBIOMIE_00202	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
HMBIOMIE_00203	5.68e-83	fxsA	-	-	S	ko:K07113	-	ko00000	COG3030 Protein affecting phage T7 exclusion by the F plasmid
HMBIOMIE_00204	2.73e-245	ytvI	-	-	S	-	-	-	sporulation integral membrane protein YtvI
HMBIOMIE_00205	9.38e-95	ytwI	-	-	S	-	-	-	membrane
HMBIOMIE_00206	1.17e-267	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
HMBIOMIE_00207	9.27e-309	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	isocitrate
HMBIOMIE_00208	1.04e-217	mdh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible oxidation of malate to oxaloacetate
HMBIOMIE_00209	3.27e-169	phoP	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_00210	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase
HMBIOMIE_00211	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMBIOMIE_00212	3.88e-200	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HMBIOMIE_00213	1.97e-137	ytaF	-	-	P	-	-	-	Probably functions as a manganese efflux pump
HMBIOMIE_00214	2.82e-126	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HMBIOMIE_00215	4.54e-205	ytbE	-	-	S	-	-	-	reductase
HMBIOMIE_00216	5.44e-260	ytbD	-	-	EGP	ko:K19577	-	ko00000,ko02000	-transporter
HMBIOMIE_00217	9.85e-88	ytcD	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00218	1.22e-246	gapB	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HMBIOMIE_00219	2.42e-88	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HMBIOMIE_00220	2.42e-105	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMBIOMIE_00221	0.0	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
HMBIOMIE_00222	1.05e-221	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
HMBIOMIE_00223	9.77e-144	ytxB	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_00224	5.98e-206	ytxC	-	-	S	-	-	-	YtxC-like family
HMBIOMIE_00225	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMBIOMIE_00226	2.07e-191	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
HMBIOMIE_00227	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_00228	1.96e-166	lytT	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
HMBIOMIE_00229	8.47e-85	lrgA	-	-	S	ko:K05338	ko02020,map02020	ko00000,ko00001,ko02000	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HMBIOMIE_00230	5.34e-150	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
HMBIOMIE_00232	1.81e-111	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMBIOMIE_00233	3.93e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
HMBIOMIE_00234	3.26e-76	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMBIOMIE_00235	1.27e-59	ysdA	-	-	S	-	-	-	Membrane
HMBIOMIE_00236	1.96e-89	ysdB	-	-	S	-	-	-	Sigma-w pathway protein YsdB
HMBIOMIE_00237	4.35e-262	ysdC	-	-	G	-	-	-	COG1363 Cellulase M and related proteins
HMBIOMIE_00238	4.21e-243	-	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
HMBIOMIE_00239	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
HMBIOMIE_00240	0.0	araB	2.7.1.16	-	C	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Belongs to the ribulokinase family
HMBIOMIE_00241	1.7e-170	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
HMBIOMIE_00242	1.05e-187	araL	-	-	G	ko:K02101	-	ko00000	Haloacid dehalogenase-like hydrolase
HMBIOMIE_00243	1.47e-288	araM	1.1.1.261	-	I	ko:K00096	ko00564,map00564	ko00000,ko00001,ko01000	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
HMBIOMIE_00244	0.0	araN	-	-	G	ko:K17234	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	carbohydrate transport
HMBIOMIE_00245	6.77e-219	araP	-	-	G	ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	carbohydrate transport
HMBIOMIE_00246	6.34e-192	araQ	-	-	G	ko:K17236	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport system permease
HMBIOMIE_00247	0.0	abfA	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	alpha-L-arabinofuranosidase activity
HMBIOMIE_00248	0.0	cstA	-	-	T	ko:K06200	-	ko00000	Carbon starvation protein
HMBIOMIE_00250	8.17e-52	ysfE	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	lactoylglutathione lyase activity
HMBIOMIE_00251	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
HMBIOMIE_00252	0.0	glcD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Glycolate oxidase subunit
HMBIOMIE_00253	6.71e-265	cdaR_1	-	-	KT	ko:K02647	-	ko00000,ko03000	regulator
HMBIOMIE_00254	7.54e-44	sspI	-	-	S	ko:K06426	-	ko00000	Belongs to the SspI family
HMBIOMIE_00255	7.68e-172	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMBIOMIE_00256	1.81e-250	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMBIOMIE_00257	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HMBIOMIE_00258	6.77e-219	rnhC	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMBIOMIE_00259	1.04e-54	zapA	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HMBIOMIE_00260	8.95e-111	yshB	-	-	S	-	-	-	membrane protein, required for colicin V production
HMBIOMIE_00261	0.0	polX	-	-	L	ko:K02347	-	ko00000,ko03400	COG1796 DNA polymerase IV (family X)
HMBIOMIE_00262	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HMBIOMIE_00263	3.76e-89	yshE	-	-	S	ko:K08989	-	ko00000	membrane
HMBIOMIE_00264	0.0	lcfA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HMBIOMIE_00265	1.21e-130	fadR	-	-	K	ko:K13770	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_00266	2.2e-176	fadB	4.2.1.17	-	I	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
HMBIOMIE_00267	2.58e-179	etfB	-	-	C	ko:K03521	-	ko00000	Electron transfer flavoprotein
HMBIOMIE_00268	1.23e-227	etfA	-	-	C	ko:K03522	-	ko00000,ko04147	Electron transfer flavoprotein
HMBIOMIE_00270	0.0	xsa	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	Alpha-L-arabinofuranosidase C-terminus
HMBIOMIE_00271	1.12e-69	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HMBIOMIE_00272	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HMBIOMIE_00273	4.83e-276	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HMBIOMIE_00274	8.53e-104	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
HMBIOMIE_00275	1.35e-140	sdhC	-	-	C	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	succinate dehydrogenase
HMBIOMIE_00276	0.0	sdhA	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
HMBIOMIE_00277	1.15e-189	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
HMBIOMIE_00278	1.79e-100	ysmA	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
HMBIOMIE_00279	1.81e-41	gerE	-	-	K	ko:K01994	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_00280	1.6e-98	ysmB	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_00281	1.15e-196	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HMBIOMIE_00282	8.03e-256	gerM	-	-	S	ko:K06298	-	ko00000	COG5401 Spore germination protein
HMBIOMIE_00283	2.04e-170	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMBIOMIE_00284	1.06e-132	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMBIOMIE_00285	4.05e-119	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
HMBIOMIE_00287	1.01e-184	ysnF	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00288	3.32e-107	ysnE	-	-	K	ko:K03829	-	ko00000,ko01000	acetyltransferase
HMBIOMIE_00290	0.0	ilvB	2.2.1.6	-	E	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
HMBIOMIE_00291	5.05e-110	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
HMBIOMIE_00292	9.59e-245	ilvC	1.1.1.86	-	EH	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMBIOMIE_00293	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMBIOMIE_00294	1.06e-255	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
HMBIOMIE_00295	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMBIOMIE_00296	5.35e-150	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMBIOMIE_00297	2.73e-240	ysoA	-	-	H	-	-	-	Tetratricopeptide repeat
HMBIOMIE_00298	8.87e-287	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HMBIOMIE_00299	1.15e-296	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMBIOMIE_00300	0.0	lonB	3.4.21.53	-	LO	ko:K04076	-	ko00000,ko01000,ko01002	Belongs to the peptidase S16 family
HMBIOMIE_00301	0.0	lon	3.4.21.53	-	O	ko:K01338	ko04112,map04112	ko00000,ko00001,ko01000,ko01002	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMBIOMIE_00302	7.6e-139	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
HMBIOMIE_00303	8.23e-117	ysxD	-	-	-	-	-	-	-
HMBIOMIE_00304	6.39e-316	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMBIOMIE_00305	6.56e-187	hemX	-	-	O	ko:K02497	-	ko00000	cytochrome C
HMBIOMIE_00306	2.66e-221	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
HMBIOMIE_00307	1.57e-187	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
HMBIOMIE_00308	6.39e-234	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the ALAD family
HMBIOMIE_00309	8.99e-315	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
HMBIOMIE_00310	0.0	spoVID	-	-	M	ko:K06417	-	ko00000	stage VI sporulation protein D
HMBIOMIE_00311	2.91e-253	ysxE	-	-	S	-	-	-	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HMBIOMIE_00312	1.53e-35	-	-	-	-	-	-	-	-
HMBIOMIE_00313	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HMBIOMIE_00314	5.8e-316	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HMBIOMIE_00315	3.15e-109	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
HMBIOMIE_00316	4.67e-215	spoIIB	-	-	S	ko:K06380	-	ko00000	Sporulation related domain
HMBIOMIE_00317	1.73e-132	maf	-	-	D	ko:K06287	-	ko00000	septum formation protein Maf
HMBIOMIE_00318	8.35e-163	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
HMBIOMIE_00319	5.26e-235	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein MreB
HMBIOMIE_00320	1.91e-202	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
HMBIOMIE_00321	8.72e-111	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	shape-determining protein
HMBIOMIE_00322	4.3e-158	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HMBIOMIE_00323	2.91e-186	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
HMBIOMIE_00324	1.83e-187	spoIVFA	-	-	M	ko:K06401	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
HMBIOMIE_00325	3.74e-208	spoIVFB	-	-	S	ko:K06402	-	ko00000,ko01000,ko01002	Stage IV sporulation protein
HMBIOMIE_00326	6.34e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
HMBIOMIE_00327	2.66e-74	ysxB	-	-	J	ko:K07584	-	ko00000	ribosomal protein
HMBIOMIE_00328	2.7e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
HMBIOMIE_00329	4.25e-139	spo0B	-	-	T	ko:K06375	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01000	Sporulation initiation phospho-transferase B, C-terminal
HMBIOMIE_00330	9.66e-309	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMBIOMIE_00331	4.75e-96	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
HMBIOMIE_00332	4.99e-209	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
HMBIOMIE_00333	5.02e-123	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
HMBIOMIE_00334	1.27e-294	nifS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
HMBIOMIE_00335	0.0	nadB	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
HMBIOMIE_00336	8.17e-208	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NadC ModD family
HMBIOMIE_00337	7.94e-273	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HMBIOMIE_00338	1.71e-217	safA	-	-	M	ko:K06370	-	ko00000	spore coat assembly protein SafA
HMBIOMIE_00339	7.28e-70	-	-	-	S	ko:K06345	-	ko00000	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMBIOMIE_00340	8.63e-165	yebC	-	-	K	-	-	-	transcriptional regulatory protein
HMBIOMIE_00341	0.0	yrbD	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
HMBIOMIE_00342	2.42e-47	-	-	-	S	-	-	-	Family of unknown function (DUF5412)
HMBIOMIE_00344	2.32e-152	yrzF	-	-	T	-	-	-	serine threonine protein kinase
HMBIOMIE_00345	2.77e-248	idhA	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
HMBIOMIE_00346	0.0	csbX	-	-	EGP	-	-	-	the major facilitator superfamily
HMBIOMIE_00347	6.46e-121	bofC	-	-	S	ko:K06318	-	ko00000	BofC C-terminal domain
HMBIOMIE_00348	2.84e-137	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HMBIOMIE_00349	9.14e-239	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HMBIOMIE_00350	2.91e-30	yrzS	-	-	S	-	-	-	Protein of unknown function (DUF2905)
HMBIOMIE_00351	6.03e-248	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMBIOMIE_00352	4.74e-292	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HMBIOMIE_00353	1.29e-52	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit YajC
HMBIOMIE_00354	1.07e-98	yrzE	-	-	S	-	-	-	Protein of unknown function (DUF3792)
HMBIOMIE_00355	6.34e-147	yrbG	-	-	S	-	-	-	membrane
HMBIOMIE_00356	0.0	spoVB	-	-	S	ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_00357	1.93e-65	yrzD	-	-	S	-	-	-	Post-transcriptional regulator
HMBIOMIE_00358	0.0	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMBIOMIE_00359	6.51e-114	trkA1	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
HMBIOMIE_00360	1.07e-64	yrvD	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
HMBIOMIE_00361	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HMBIOMIE_00362	2.53e-118	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMBIOMIE_00363	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMBIOMIE_00364	1.36e-90	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HMBIOMIE_00365	0.0	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
HMBIOMIE_00367	1.27e-311	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
HMBIOMIE_00368	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMBIOMIE_00369	3.96e-177	yrvM	-	-	H	ko:K22132	-	ko00000,ko03016	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
HMBIOMIE_00370	2.33e-301	rarA	-	-	L	ko:K07478	-	ko00000	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
HMBIOMIE_00371	8.12e-93	cymR	-	-	K	ko:K17472	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_00372	2.67e-272	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
HMBIOMIE_00373	1.19e-280	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HMBIOMIE_00374	1.01e-20	yrrB	-	-	S	-	-	-	COG0457 FOG TPR repeat
HMBIOMIE_00375	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HMBIOMIE_00376	9.73e-106	yrrD	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00377	8.4e-42	yrzR	-	-	-	-	-	-	-
HMBIOMIE_00378	5.38e-12	-	-	-	S	-	-	-	Protein of unknown function (DUF3918)
HMBIOMIE_00379	9.26e-140	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_00380	2.28e-139	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_00381	7.39e-187	glnH	-	-	ET	ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
HMBIOMIE_00382	7.7e-169	glnQ	-	-	E	ko:K09972,ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
HMBIOMIE_00383	3.07e-242	yrrI	-	-	S	-	-	-	AI-2E family transporter
HMBIOMIE_00384	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMBIOMIE_00385	2.22e-55	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
HMBIOMIE_00386	5.49e-93	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMBIOMIE_00387	2.94e-60	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
HMBIOMIE_00388	7.51e-242	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMBIOMIE_00389	1.7e-155	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-methyltransferase
HMBIOMIE_00390	6.57e-224	yrrN	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
HMBIOMIE_00391	4.62e-313	yrrO	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	COG0826 Collagenase and related proteases
HMBIOMIE_00392	4.51e-148	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
HMBIOMIE_00393	1.14e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HMBIOMIE_00394	0.0	pbpI	-	-	M	ko:K21468	-	ko00000,ko01011	Penicillin-binding Protein
HMBIOMIE_00395	1.42e-102	yrrS	-	-	S	-	-	-	Protein of unknown function (DUF1510)
HMBIOMIE_00396	8.52e-37	yrzA	-	-	S	-	-	-	Protein of unknown function (DUF2536)
HMBIOMIE_00397	7.23e-155	yrrT	-	-	Q	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Could be a S-adenosyl-L-methionine-dependent methyltransferase
HMBIOMIE_00398	1.97e-161	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMBIOMIE_00399	7.04e-218	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Cysteine synthase
HMBIOMIE_00400	9.98e-268	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HMBIOMIE_00401	1.99e-48	yrhC	-	-	S	-	-	-	YrhC-like protein
HMBIOMIE_00402	4.26e-103	yrhD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
HMBIOMIE_00403	0.0	yjgC	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase (NAD+) activity
HMBIOMIE_00404	4.41e-80	yrhF	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2294)
HMBIOMIE_00406	1.38e-183	yrhG	-	-	P	ko:K21993	-	ko00000,ko02000	Formate nitrite
HMBIOMIE_00408	9.39e-08	-	-	-	S	-	-	-	Probable sporulation protein (Bac_small_yrzI)
HMBIOMIE_00409	1.1e-126	yrhH	-	-	Q	-	-	-	methyltransferase
HMBIOMIE_00410	1.12e-135	-	-	-	K	ko:K22106	-	ko00000,ko03000	Tetracycline repressor, C-terminal all-alpha domain
HMBIOMIE_00411	0.0	yrhJ	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
HMBIOMIE_00412	4.43e-61	yrhK	-	-	S	-	-	-	YrhK-like protein
HMBIOMIE_00413	0.0	oatA	-	-	I	-	-	-	Acyltransferase family
HMBIOMIE_00414	3.67e-193	rsiV	-	-	S	-	-	-	Protein of unknown function (DUF3298)
HMBIOMIE_00415	9.97e-114	sigV	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_00416	5.9e-194	yrhO	-	-	K	-	-	-	Archaeal transcriptional regulator TrmB
HMBIOMIE_00417	5.63e-137	yrhP	-	-	E	-	-	-	LysE type translocator
HMBIOMIE_00418	0.0	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_00419	0.0	levR	-	-	K	-	-	-	PTS system fructose IIA component
HMBIOMIE_00420	2.66e-97	levD	2.7.1.191, 2.7.1.202	-	G	ko:K02793,ko:K02794,ko:K11194	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HMBIOMIE_00421	7.63e-107	ptnA	2.7.1.191, 2.7.1.202	-	G	ko:K02793,ko:K02794,ko:K11195	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system mannose fructose sorbose family
HMBIOMIE_00422	6.11e-168	levF	-	-	G	ko:K02746,ko:K02795,ko:K11196	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
HMBIOMIE_00423	1.39e-192	levG	-	-	G	ko:K02771,ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
HMBIOMIE_00424	0.0	sacC	3.2.1.80	-	G	ko:K03332	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
HMBIOMIE_00425	1.58e-116	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
HMBIOMIE_00426	8.68e-256	adhA	-	-	C	ko:K13979	-	ko00000,ko01000	alcohol dehydrogenase
HMBIOMIE_00427	3.03e-40	yphJ	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	peroxiredoxin activity
HMBIOMIE_00428	3.17e-68	adhR	-	-	K	ko:K21745	-	ko00000,ko03000	helix_turn_helix, mercury resistance
HMBIOMIE_00429	7.23e-66	yraD	-	-	M	ko:K06439	-	ko00000	Spore coat protein
HMBIOMIE_00430	1.05e-36	yraE	-	-	-	ko:K06440	-	ko00000	-
HMBIOMIE_00431	9.1e-284	adhB	1.1.1.1, 1.1.1.284, 1.2.1.46	-	E	ko:K00121,ko:K00148	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HMBIOMIE_00432	9.61e-84	yraF	-	-	M	-	-	-	Spore coat protein
HMBIOMIE_00433	4.19e-50	yraG	-	-	-	ko:K06440	-	ko00000	-
HMBIOMIE_00434	6.62e-87	-	-	-	E	-	-	-	Glyoxalase-like domain
HMBIOMIE_00435	2.92e-81	-	-	-	T	-	-	-	sh3 domain protein
HMBIOMIE_00436	6.61e-80	-	-	-	T	-	-	-	sh3 domain protein
HMBIOMIE_00437	4.9e-200	-	-	-	S	-	-	-	Alpha beta hydrolase
HMBIOMIE_00438	6.15e-57	yraL	-	-	S	-	-	-	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_00439	5.73e-202	csn	3.2.1.132	-	M	ko:K01233	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
HMBIOMIE_00441	5.95e-263	yraM	-	-	S	-	-	-	PrpF protein
HMBIOMIE_00442	2.97e-210	yraN	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00443	9.19e-287	yraO	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
HMBIOMIE_00444	5.96e-240	yrpG	-	-	C	-	-	-	Aldo/keto reductase family
HMBIOMIE_00445	1.1e-124	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_00446	9.28e-170	zinT	-	-	S	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
HMBIOMIE_00448	5.87e-163	yrpD	-	-	S	-	-	-	Domain of unknown function, YrpD
HMBIOMIE_00449	8.73e-191	murI	5.1.1.3	-	M	ko:K01776	ko00471,ko01100,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HMBIOMIE_00450	4.23e-246	npd	1.13.12.16	-	S	ko:K00459	ko00910,map00910	ko00000,ko00001,ko01000	COG2070 Dioxygenases related to 2-nitropropane dioxygenase
HMBIOMIE_00451	4.23e-212	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
HMBIOMIE_00452	1.42e-118	yrdA	-	-	S	-	-	-	DinB family
HMBIOMIE_00453	8.93e-73	-	-	-	S	-	-	-	Protein of unknown function (DUF2568)
HMBIOMIE_00454	2.11e-130	yrdC	-	-	Q	-	-	-	Isochorismatase family
HMBIOMIE_00456	8.53e-287	cypA	1.14.14.46, 1.14.15.13	-	C	ko:K15468,ko:K16593,ko:K17474	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
HMBIOMIE_00457	1.76e-22	yrdF	-	-	K	ko:K03623	-	ko00000	ribonuclease inhibitor
HMBIOMIE_00458	4.13e-104	bkdR	-	-	K	-	-	-	helix_turn_helix ASNC type
HMBIOMIE_00459	2.2e-174	azlC	-	-	E	-	-	-	AzlC protein
HMBIOMIE_00460	5.64e-66	azlD	-	-	E	-	-	-	Branched-chain amino acid transport protein (AzlD)
HMBIOMIE_00461	1.17e-290	brnQ	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HMBIOMIE_00462	2.43e-208	-	-	-	K	ko:K21959	-	ko00000,ko03000	LysR substrate binding domain
HMBIOMIE_00463	1.75e-87	yodA	-	-	S	-	-	-	tautomerase
HMBIOMIE_00464	2.05e-204	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	COG1230 Co Zn Cd efflux system component
HMBIOMIE_00465	6.09e-254	trkA	-	-	P	ko:K07222	-	ko00000	Oxidoreductase
HMBIOMIE_00466	9.87e-204	-	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00467	7.28e-218	yrdR	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_00468	2.45e-23	-	-	-	S	-	-	-	YrzO-like protein
HMBIOMIE_00469	1.02e-297	yrkA	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
HMBIOMIE_00470	7.23e-107	bltD	2.3.1.57	-	K	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	FR47-like protein
HMBIOMIE_00471	6.23e-268	blt	-	-	EGP	ko:K08153,ko:K19578	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_00472	1.24e-194	bltR	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HMBIOMIE_00473	6.33e-138	yrkC	-	-	G	-	-	-	Cupin domain
HMBIOMIE_00474	4.38e-52	yrkD	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00475	6.83e-109	yrkE	-	-	O	-	-	-	DsrE/DsrF/DrsH-like family
HMBIOMIE_00476	2.04e-129	yrkF	-	-	OP	-	-	-	Belongs to the sulfur carrier protein TusA family
HMBIOMIE_00477	2.1e-272	yrkH	-	-	P	-	-	-	Rhodanese Homology Domain
HMBIOMIE_00478	1.11e-49	yrkI	-	-	O	-	-	-	Belongs to the sulfur carrier protein TusA family
HMBIOMIE_00479	8.33e-162	yrkJ	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HMBIOMIE_00480	3.13e-104	-	-	-	S	-	-	-	Protein of unknown function with HXXEE motif
HMBIOMIE_00481	5.71e-126	yrkL	-	-	S	ko:K11748	-	ko00000,ko02000	Flavodoxin-like fold
HMBIOMIE_00482	7.39e-132	yrkN	-	-	K	-	-	-	Acetyltransferase (GNAT) family
HMBIOMIE_00483	7.53e-283	yrkO	-	-	P	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
HMBIOMIE_00484	1.24e-164	yrkP	-	-	T	ko:K02483	-	ko00000,ko02022	Transcriptional regulator
HMBIOMIE_00485	4.23e-305	yrkQ	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_00486	2.15e-90	psiE	-	-	S	ko:K13256	-	ko00000	Protein PsiE homolog
HMBIOMIE_00487	1.42e-78	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_00488	2.25e-131	xkdA	-	-	E	-	-	-	IrrE N-terminal-like domain
HMBIOMIE_00489	8.73e-132	yqaC	-	-	F	-	-	-	adenylate kinase activity
HMBIOMIE_00491	1.25e-74	-	-	-	K	-	-	-	sequence-specific DNA binding
HMBIOMIE_00492	3.43e-49	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HMBIOMIE_00494	1.27e-134	-	-	-	-	-	-	-	-
HMBIOMIE_00498	9.38e-229	yqaJ	-	-	L	-	-	-	YqaJ-like viral recombinase domain
HMBIOMIE_00499	1.1e-198	recT	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
HMBIOMIE_00500	1.92e-158	yqaL	-	-	L	-	-	-	DnaD domain protein
HMBIOMIE_00501	4.9e-214	yqaM	-	-	L	-	-	-	IstB-like ATP binding protein
HMBIOMIE_00503	1.38e-97	rusA	-	-	L	-	-	-	Endodeoxyribonuclease RusA
HMBIOMIE_00504	2.49e-43	yqaO	-	-	S	-	-	-	Phage-like element PBSX protein XtrA
HMBIOMIE_00505	7.56e-214	-	-	-	-	-	-	-	-
HMBIOMIE_00506	1.58e-105	yqaQ	-	-	L	-	-	-	Transposase
HMBIOMIE_00508	2.02e-158	yqaS	-	-	L	-	-	-	DNA packaging
HMBIOMIE_00509	0.0	yqaT	-	-	S	ko:K06909	-	ko00000	phage terminase, large subunit
HMBIOMIE_00510	0.0	yqbA	-	-	S	-	-	-	portal protein
HMBIOMIE_00511	1.73e-217	-	-	-	S	-	-	-	Phage Mu protein F like protein
HMBIOMIE_00512	2.13e-149	-	-	-	-	-	-	-	-
HMBIOMIE_00513	5.46e-186	yqbD	-	-	L	-	-	-	Putative phage serine protease XkdF
HMBIOMIE_00514	9.21e-216	xkdG	-	-	S	-	-	-	Phage capsid family
HMBIOMIE_00515	2.47e-68	-	-	-	S	-	-	-	YqbF, hypothetical protein domain
HMBIOMIE_00516	7.09e-88	-	-	-	S	-	-	-	Protein of unknown function (DUF3199)
HMBIOMIE_00517	7.08e-85	yqbH	-	-	S	-	-	-	Domain of unknown function (DUF3599)
HMBIOMIE_00518	7.59e-123	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
HMBIOMIE_00519	3.24e-102	yqbJ	-	-	-	-	-	-	-
HMBIOMIE_00520	2.52e-36	-	-	-	-	-	-	-	-
HMBIOMIE_00521	0.0	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
HMBIOMIE_00522	4.23e-99	xkdM	-	-	S	-	-	-	Phage tail tube protein
HMBIOMIE_00524	9.14e-88	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
HMBIOMIE_00525	0.0	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
HMBIOMIE_00526	6.56e-156	xkdP	-	-	S	-	-	-	Lysin motif
HMBIOMIE_00527	1.02e-231	xkdQ	-	-	G	-	-	-	NLP P60 protein
HMBIOMIE_00528	6.68e-52	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
HMBIOMIE_00529	1.14e-91	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
HMBIOMIE_00530	1.31e-245	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMBIOMIE_00531	4.58e-134	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
HMBIOMIE_00532	3e-54	-	-	-	-	-	-	-	-
HMBIOMIE_00533	2.91e-283	-	-	-	-	-	-	-	-
HMBIOMIE_00534	1.01e-73	xkdW	-	-	S	-	-	-	XkdW protein
HMBIOMIE_00535	9.34e-33	-	-	-	-	-	-	-	-
HMBIOMIE_00536	2.45e-213	xepA	-	-	-	-	-	-	-
HMBIOMIE_00537	8.36e-89	-	-	-	S	-	-	-	Bacteriophage holin family
HMBIOMIE_00538	9.72e-187	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
HMBIOMIE_00540	5.4e-80	-	-	-	-	-	-	-	-
HMBIOMIE_00542	1.37e-135	-	-	-	S	ko:K21492	-	ko00000,ko02048	Suppressor of fused protein (SUFU)
HMBIOMIE_00543	0.0	-	-	-	A	ko:K21491	-	ko00000,ko01000,ko02048	Pre-toxin TG
HMBIOMIE_00546	8.68e-120	-	-	-	S	-	-	-	Tetratricopeptide repeat
HMBIOMIE_00547	2.08e-197	yqcI	-	-	S	ko:K09190	-	ko00000	YqcI/YcgG family
HMBIOMIE_00548	1.53e-72	arsR	-	-	K	ko:K03892	-	ko00000,ko03000	ArsR family transcriptional regulator
HMBIOMIE_00549	2.56e-104	cadI	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_00550	7.13e-233	arsB	-	-	P	ko:K03325	-	ko00000,ko02000	Arsenic resistance protein
HMBIOMIE_00551	9.82e-101	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Catalyzes the reduction of arsenate As(V) to arsenite As(III)
HMBIOMIE_00552	0.0	-	-	-	L	ko:K06400	-	ko00000	Recombinase
HMBIOMIE_00553	1.1e-72	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_00554	2.53e-97	nucB	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
HMBIOMIE_00555	9.38e-171	-	-	-	-	-	-	-	-
HMBIOMIE_00556	7.95e-219	yqeC	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconate dehydrogenase
HMBIOMIE_00557	3.97e-136	yqeD	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_00558	7.45e-180	xlyA	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	n-acetylmuramoyl-L-alanine amidase
HMBIOMIE_00559	2.24e-182	yqeF	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HMBIOMIE_00561	2.17e-123	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
HMBIOMIE_00562	4.78e-273	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
HMBIOMIE_00563	8.44e-201	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMBIOMIE_00564	8.95e-61	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein containing KH domain, possibly ribosomal protein
HMBIOMIE_00565	2.47e-141	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMBIOMIE_00566	4.81e-133	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
HMBIOMIE_00567	9.76e-82	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HMBIOMIE_00568	9.8e-179	yqeM	-	-	Q	-	-	-	Methyltransferase
HMBIOMIE_00569	2.69e-189	comER	-	-	E	ko:K02239	-	ko00000,ko00002,ko02044	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMBIOMIE_00570	6.65e-138	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
HMBIOMIE_00571	3.25e-137	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
HMBIOMIE_00572	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
HMBIOMIE_00573	2.36e-22	-	-	-	S	-	-	-	YqzM-like protein
HMBIOMIE_00574	2.01e-244	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
HMBIOMIE_00575	4e-49	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
HMBIOMIE_00576	4.16e-259	gpr	3.4.24.78	-	C	ko:K06012	-	ko00000,ko01000,ko01002	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HMBIOMIE_00577	9.53e-284	spoIIP	-	-	M	ko:K06385	-	ko00000	stage II sporulation protein P
HMBIOMIE_00578	7.06e-70	yqxA	-	-	S	-	-	-	Protein of unknown function (DUF3679)
HMBIOMIE_00579	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HMBIOMIE_00580	2.9e-276	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
HMBIOMIE_00581	1.65e-241	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HMBIOMIE_00582	4.36e-116	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMBIOMIE_00583	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
HMBIOMIE_00584	3.41e-257	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HMBIOMIE_00585	5.63e-226	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Methylates ribosomal protein L11
HMBIOMIE_00586	1.01e-180	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HMBIOMIE_00587	0.0	yqeV	2.8.4.5	-	J	ko:K18707	-	ko00000,ko01000,ko03016	ribosomal protein S12 methylthiotransferase
HMBIOMIE_00588	3.45e-202	yqeW	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
HMBIOMIE_00589	1.03e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
HMBIOMIE_00590	2.25e-90	yqeY	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
HMBIOMIE_00591	7.97e-292	yqeZ	-	-	O	ko:K07403	-	ko00000	COG1030 Membrane-bound serine protease (ClpP class)
HMBIOMIE_00592	4.35e-192	yqfA	-	-	S	-	-	-	UPF0365 protein
HMBIOMIE_00593	3.13e-79	yqfB	-	-	-	-	-	-	-
HMBIOMIE_00594	2.07e-60	yqfC	-	-	S	-	-	-	sporulation protein YqfC
HMBIOMIE_00595	1.04e-242	yqfD	-	-	S	ko:K06438	-	ko00000	Stage IV sporulation
HMBIOMIE_00596	2.47e-224	phoH	-	-	T	ko:K06217	-	ko00000	Phosphate starvation-inducible protein PhoH
HMBIOMIE_00598	0.0	yqfF	-	-	S	ko:K07037	-	ko00000	membrane-associated HD superfamily hydrolase
HMBIOMIE_00599	8.68e-106	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMBIOMIE_00600	1.42e-81	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
HMBIOMIE_00601	6.71e-93	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HMBIOMIE_00602	9.98e-215	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMBIOMIE_00603	5.29e-27	-	-	-	S	-	-	-	YqzL-like protein
HMBIOMIE_00604	5.26e-187	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
HMBIOMIE_00605	2.12e-222	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
HMBIOMIE_00606	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
HMBIOMIE_00607	3.29e-144	ccpN	-	-	K	-	-	-	CBS domain
HMBIOMIE_00608	6.38e-191	yqfL	2.7.11.33, 2.7.4.28	-	S	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HMBIOMIE_00609	6.03e-114	yqxD	-	-	S	ko:K09768	-	ko00000	Belongs to the UPF0178 family
HMBIOMIE_00610	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HMBIOMIE_00611	2.79e-254	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HMBIOMIE_00612	1.61e-81	cccA	-	-	C	ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
HMBIOMIE_00613	2.41e-150	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
HMBIOMIE_00614	2.27e-270	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMBIOMIE_00615	8.66e-227	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMBIOMIE_00616	4.89e-58	yqfQ	-	-	S	-	-	-	YqfQ-like protein
HMBIOMIE_00617	5.42e-311	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HMBIOMIE_00618	1.04e-214	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HMBIOMIE_00619	3.01e-49	yqfT	-	-	S	-	-	-	Protein of unknown function (DUF2624)
HMBIOMIE_00620	3.83e-199	yqfU	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
HMBIOMIE_00621	8.59e-107	zur	-	-	P	ko:K02076	-	ko00000,ko03000	Belongs to the Fur family
HMBIOMIE_00622	8.25e-142	yqfW	-	-	S	ko:K05967	-	ko00000	Belongs to the 5'(3')-deoxyribonucleotidase family
HMBIOMIE_00623	2.04e-81	yqfX	-	-	S	-	-	-	membrane
HMBIOMIE_00624	5.22e-257	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMBIOMIE_00625	2.84e-63	yqfZ	-	-	M	ko:K06417	-	ko00000	LysM domain
HMBIOMIE_00626	2.05e-99	yqgA	-	-	-	-	-	-	-
HMBIOMIE_00627	9.27e-172	yqgB	-	-	S	-	-	-	Protein of unknown function (DUF1189)
HMBIOMIE_00628	8.25e-101	yqgC	-	-	S	ko:K09793	-	ko00000	protein conserved in bacteria
HMBIOMIE_00629	1.59e-148	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
HMBIOMIE_00630	3.96e-293	yqgE	-	-	EGP	ko:K08222	-	ko00000,ko02000	Major facilitator superfamily
HMBIOMIE_00631	0.0	pbpA	-	-	M	ko:K21465,ko:K21466	ko00550,map00550	ko00000,ko00001,ko01011	penicillin-binding protein
HMBIOMIE_00632	4.51e-206	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HMBIOMIE_00633	7.43e-205	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HMBIOMIE_00634	5.26e-202	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
HMBIOMIE_00635	2.4e-190	pstBA	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMBIOMIE_00636	2.71e-187	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HMBIOMIE_00637	2.92e-98	yqzC	-	-	S	-	-	-	YceG-like family
HMBIOMIE_00638	3.42e-68	yqzD	-	-	-	-	-	-	-
HMBIOMIE_00640	1.24e-260	yqgM	2.4.1.250	-	M	ko:K15521	-	ko00000,ko01000	Glycosyl transferases group 1
HMBIOMIE_00641	6.25e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HMBIOMIE_00642	2.38e-138	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMBIOMIE_00643	3.38e-14	yqgO	-	-	-	-	-	-	-
HMBIOMIE_00644	0.0	gluP	3.4.21.105	-	O	ko:K19225	-	ko00000,ko01000,ko01002	membrane protein (homolog of Drosophila rhomboid)
HMBIOMIE_00645	9.15e-45	yqgQ	-	-	S	-	-	-	Protein conserved in bacteria
HMBIOMIE_00646	2.81e-231	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
HMBIOMIE_00647	0.0	yqgS	2.7.8.20	-	M	ko:K01138,ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
HMBIOMIE_00648	1.06e-283	yqgT	3.4.19.11	-	E	ko:K01308	-	ko00000,ko01000,ko01002	Gamma-D-glutamyl-L-diamino acid endopeptidase
HMBIOMIE_00649	5.65e-258	yqgU	-	-	-	-	-	-	-
HMBIOMIE_00650	7.34e-66	yqgV	-	-	S	-	-	-	Thiamine-binding protein
HMBIOMIE_00651	1.91e-31	yqgW	-	-	S	-	-	-	Protein of unknown function (DUF2759)
HMBIOMIE_00652	5.52e-158	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
HMBIOMIE_00653	1.46e-50	yqgY	-	-	S	-	-	-	Protein of unknown function (DUF2626)
HMBIOMIE_00654	7.79e-85	yqgZ	1.20.4.1	-	P	ko:K00537,ko:K16509	-	ko00000,ko01000	Belongs to the ArsC family
HMBIOMIE_00656	1.06e-193	yqhA	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMBIOMIE_00657	8.56e-307	yqhB	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
HMBIOMIE_00658	1.51e-233	yqxL	-	-	P	-	-	-	Mg2 transporter protein
HMBIOMIE_00660	9.05e-257	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMBIOMIE_00661	1.29e-220	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
HMBIOMIE_00662	5.33e-63	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
HMBIOMIE_00663	9.7e-94	gspH	-	-	NU	ko:K02246,ko:K02457,ko:K02459,ko:K02672,ko:K08084,ko:K10926	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02035,ko02044	protein transport across the cell outer membrane
HMBIOMIE_00664	4.35e-79	comGE	-	-	-	ko:K02247	-	ko00000,ko00002,ko02044	-
HMBIOMIE_00665	3.44e-65	comGF	-	-	U	ko:K02246,ko:K02248	-	ko00000,ko00002,ko02044	Putative Competence protein ComGF
HMBIOMIE_00666	2.55e-55	-	-	-	S	ko:K02249	-	ko00000,ko00002,ko02044	ComG operon protein 7
HMBIOMIE_00667	4.9e-37	yqzE	-	-	S	-	-	-	YqzE-like protein
HMBIOMIE_00668	6.36e-71	yqzG	-	-	S	-	-	-	Protein of unknown function (DUF3889)
HMBIOMIE_00669	2.29e-155	yqxM	-	-	-	ko:K19433	-	ko00000	-
HMBIOMIE_00670	4.27e-97	sipW	3.4.21.89	-	U	ko:K13280	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase
HMBIOMIE_00671	1.28e-181	tasA_1	-	-	S	ko:K06336	-	ko00000,ko01002	Cell division protein FtsN
HMBIOMIE_00672	3.69e-72	sinR	-	-	K	ko:K19449	-	ko00000,ko03000	transcriptional
HMBIOMIE_00673	4.84e-34	sinI	-	-	S	ko:K06372	-	ko00000	Anti-repressor SinI
HMBIOMIE_00674	9.14e-197	yqhG	-	-	S	-	-	-	Bacterial protein YqhG of unknown function
HMBIOMIE_00675	0.0	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
HMBIOMIE_00676	5.49e-261	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine
HMBIOMIE_00677	0.0	gcvPA	1.4.4.2	-	E	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMBIOMIE_00678	0.0	gcvPB	1.4.4.2	-	E	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMBIOMIE_00679	7.5e-83	yqhL	-	-	P	-	-	-	COG0607 Rhodanese-related sulfurtransferase
HMBIOMIE_00680	1.12e-204	lipM	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
HMBIOMIE_00681	1.97e-97	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
HMBIOMIE_00682	1.21e-210	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
HMBIOMIE_00683	5.18e-81	yqhP	-	-	-	-	-	-	-
HMBIOMIE_00684	4.42e-222	yqhQ	-	-	S	-	-	-	Protein of unknown function (DUF1385)
HMBIOMIE_00685	8.02e-121	yqhR	-	-	S	-	-	-	Conserved membrane protein YqhR
HMBIOMIE_00686	1.17e-101	aroQ	4.2.1.10	-	E	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a trans-dehydration via an enolate intermediate
HMBIOMIE_00687	3.65e-250	yqhT	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
HMBIOMIE_00688	4.8e-128	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMBIOMIE_00689	6.96e-50	yqhV	-	-	S	-	-	-	Protein of unknown function (DUF2619)
HMBIOMIE_00690	1.22e-218	spoIIIAA	-	-	S	ko:K06390	-	ko00000	stage III sporulation protein AA
HMBIOMIE_00691	6.93e-112	spoIIIAB	-	-	S	ko:K06391	-	ko00000	Stage III sporulation protein
HMBIOMIE_00692	1.63e-39	spoIIIAC	-	-	S	ko:K06392	-	ko00000	stage III sporulation protein AC
HMBIOMIE_00693	1.93e-77	spoIIIAD	-	-	S	ko:K06393	-	ko00000	Stage III sporulation protein AD
HMBIOMIE_00694	7.65e-257	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
HMBIOMIE_00695	1.28e-131	spoIIIAF	-	-	S	ko:K06395	-	ko00000	Stage III sporulation protein AF (Spore_III_AF)
HMBIOMIE_00696	9.25e-150	spoIIIAG	-	-	S	ko:K06396	-	ko00000	stage III sporulation protein AG
HMBIOMIE_00697	9.92e-135	spoIIIAH	-	-	S	ko:K06397	-	ko00000	SpoIIIAH-like protein
HMBIOMIE_00698	3.21e-93	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HMBIOMIE_00699	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
HMBIOMIE_00700	1.65e-88	yqhY	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00701	4.8e-86	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMBIOMIE_00702	1.07e-200	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMBIOMIE_00703	2.5e-312	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HMBIOMIE_00704	1.09e-51	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HMBIOMIE_00705	4.2e-209	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HMBIOMIE_00706	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMBIOMIE_00707	1.77e-198	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
HMBIOMIE_00708	3.75e-103	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HMBIOMIE_00709	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
HMBIOMIE_00710	1.26e-303	spoIVB	3.4.21.116	-	M	ko:K06399	-	ko00000,ko01000,ko01002	Stage IV sporulation protein B
HMBIOMIE_00711	1.89e-186	spo0A	-	-	KT	ko:K07699	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
HMBIOMIE_00713	1.77e-276	yqiG	-	-	C	-	-	-	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
HMBIOMIE_00714	2.26e-37	-	-	-	-	-	-	-	-
HMBIOMIE_00715	5.67e-139	lytC_1	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Cell wall hydrolase autolysin
HMBIOMIE_00716	7.42e-172	yqiK	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HMBIOMIE_00717	5.7e-281	mmgA	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HMBIOMIE_00718	7.2e-201	mmgB	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	Dehydrogenase
HMBIOMIE_00719	5.16e-270	mmgC	-	-	I	ko:K18244	-	ko00000,ko01000	acyl-CoA dehydrogenase
HMBIOMIE_00720	1.66e-267	mmgD	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
HMBIOMIE_00721	0.0	prpD	4.2.1.79	-	S	ko:K01720	ko00640,map00640	ko00000,ko00001,ko01000	2-methylcitrate dehydratase
HMBIOMIE_00722	7.23e-208	prpB	4.1.3.30, 5.4.2.9	-	G	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HMBIOMIE_00723	1.56e-46	yqzF	-	-	S	-	-	-	Protein of unknown function (DUF2627)
HMBIOMIE_00724	0.0	bkdR	-	-	KT	-	-	-	Transcriptional regulator
HMBIOMIE_00725	1.74e-198	ptb	2.3.1.19	-	C	ko:K00634	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	phosphate butyryltransferase
HMBIOMIE_00726	1.92e-262	ldh	1.4.1.9	-	E	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
HMBIOMIE_00727	1.18e-255	buk	2.7.2.7	-	C	ko:K00929	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	Belongs to the acetokinase family
HMBIOMIE_00728	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMBIOMIE_00729	1.92e-238	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMBIOMIE_00730	6.92e-235	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMBIOMIE_00731	1.57e-296	bkdB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMBIOMIE_00732	6.38e-195	-	-	-	K	ko:K19575	-	ko00000,ko00002,ko03000	helix_turn_helix, mercury resistance
HMBIOMIE_00733	3.09e-267	norA	-	-	EGP	ko:K08153,ko:K19576,ko:K19578	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_00734	4.23e-214	bmrU	-	-	I	-	-	-	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HMBIOMIE_00735	3.79e-101	yqiW	-	-	S	-	-	-	Belongs to the UPF0403 family
HMBIOMIE_00736	1.43e-175	artP	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
HMBIOMIE_00737	8.94e-143	artQ	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
HMBIOMIE_00738	1.28e-166	artM	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
HMBIOMIE_00739	9.33e-226	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
HMBIOMIE_00740	2.41e-128	yqjB	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00742	7.17e-99	mce	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0346 Lactoylglutathione lyase and related lyases
HMBIOMIE_00743	0.0	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HMBIOMIE_00744	5.26e-259	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	COG2195 Di- and tripeptidases
HMBIOMIE_00745	8.77e-184	yqjF	-	-	S	ko:K09166	-	ko00000	Uncharacterized conserved protein (COG2071)
HMBIOMIE_00746	3.36e-184	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMBIOMIE_00747	1.77e-32	yqzJ	-	-	-	-	-	-	-
HMBIOMIE_00748	2.72e-301	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_00749	0.0	gnd	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMBIOMIE_00750	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMBIOMIE_00751	7.66e-222	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HMBIOMIE_00752	3.86e-188	yqjL	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMBIOMIE_00753	1.21e-245	namA	1.6.99.1	-	C	ko:K00354	-	ko00000,ko01000	Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
HMBIOMIE_00754	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
HMBIOMIE_00755	6.84e-190	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMBIOMIE_00756	3.98e-230	yqjP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
HMBIOMIE_00757	3.41e-185	yqjQ	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_00758	0.0	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
HMBIOMIE_00759	6.6e-229	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HMBIOMIE_00760	1.33e-95	yqjT	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_00762	1.08e-289	yqjV	-	-	G	-	-	-	Major Facilitator Superfamily
HMBIOMIE_00764	4.03e-304	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_00765	1.87e-65	yqiX	-	-	S	-	-	-	YolD-like protein
HMBIOMIE_00766	5.46e-113	yqjY	-	-	K	ko:K06977	-	ko00000	acetyltransferase
HMBIOMIE_00767	5.51e-79	yqjZ	-	-	S	-	-	-	enzyme involved in biosynthesis of extracellular polysaccharides
HMBIOMIE_00768	2.89e-251	yqkA	-	-	K	-	-	-	GrpB protein
HMBIOMIE_00769	6.17e-73	yqkB	-	-	S	-	-	-	Belongs to the HesB IscA family
HMBIOMIE_00770	1.12e-53	yqkC	-	-	S	-	-	-	Protein of unknown function (DUF2552)
HMBIOMIE_00771	4.29e-227	yqkD	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
HMBIOMIE_00772	1.78e-29	yqkE	-	-	S	-	-	-	Protein of unknown function (DUF3886)
HMBIOMIE_00773	9.26e-218	yqkF	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
HMBIOMIE_00774	8.21e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF3936)
HMBIOMIE_00775	4.07e-120	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
HMBIOMIE_00776	2.62e-283	yqxK	-	-	L	-	-	-	DNA helicase
HMBIOMIE_00777	3.18e-77	ansR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00778	1.77e-238	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase
HMBIOMIE_00779	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Aspartate ammonia-lyase
HMBIOMIE_00780	0.0	mleN	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
HMBIOMIE_00781	3.95e-309	mleA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
HMBIOMIE_00782	3.73e-44	yqkK	-	-	-	-	-	-	-
HMBIOMIE_00783	1.96e-139	spoIIM	-	-	S	ko:K06384	-	ko00000	Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
HMBIOMIE_00784	2.26e-104	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
HMBIOMIE_00785	2.73e-50	-	-	-	S	-	-	-	Protein of unknown function (DUF4227)
HMBIOMIE_00786	3.91e-214	xerD	-	-	L	ko:K04763	-	ko00000,ko03036	recombinase XerD
HMBIOMIE_00787	2.89e-295	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HMBIOMIE_00788	1.39e-190	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMBIOMIE_00789	2.89e-272	dacF	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HMBIOMIE_00790	1.98e-76	spoIIAA	-	-	T	ko:K06378	-	ko00000	Belongs to the anti-sigma-factor antagonist family
HMBIOMIE_00791	6.78e-100	spoIIAB	2.7.11.1	-	F	ko:K06379	-	ko00000,ko01000	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
HMBIOMIE_00792	1.18e-174	sigF	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_00793	5.72e-144	spoVAA	-	-	S	ko:K06403	-	ko00000	Stage V sporulation protein AA
HMBIOMIE_00794	5.43e-90	spoVAB	-	-	S	ko:K06404	-	ko00000	Stage V sporulation protein AB
HMBIOMIE_00795	6.71e-102	spoVAC	-	-	S	ko:K06405	-	ko00000	stage V sporulation protein AC
HMBIOMIE_00796	6.02e-246	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
HMBIOMIE_00797	2.15e-75	spoVAEB	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
HMBIOMIE_00798	1.85e-143	-	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
HMBIOMIE_00799	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Stage V sporulation protein AF
HMBIOMIE_00800	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HMBIOMIE_00801	2.67e-193	ypuA	-	-	S	-	-	-	Secreted protein
HMBIOMIE_00802	1.23e-105	ppiB	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMBIOMIE_00804	3.82e-09	-	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_00806	1.28e-45	ypzJ	-	-	S	ko:K07069	-	ko00000	nucleic-acid-binding protein containing a Zn-ribbon domain
HMBIOMIE_00807	1.18e-132	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HMBIOMIE_00808	2.96e-72	ypuD	-	-	-	-	-	-	-
HMBIOMIE_00809	1.77e-261	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMBIOMIE_00810	1.24e-147	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
HMBIOMIE_00811	3.12e-292	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMBIOMIE_00812	8.41e-107	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
HMBIOMIE_00813	1.12e-83	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_00814	3.18e-123	ypuF	-	-	S	ko:K09763	-	ko00000	Domain of unknown function (DUF309)
HMBIOMIE_00815	1.33e-167	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HMBIOMIE_00816	2e-135	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMBIOMIE_00817	6.13e-128	ypuI	-	-	S	-	-	-	Protein of unknown function (DUF3907)
HMBIOMIE_00818	4.11e-273	dacB	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HMBIOMIE_00819	7.57e-135	spmA	-	-	S	ko:K06373	-	ko00000	Spore maturation protein
HMBIOMIE_00820	8.62e-114	spmB	-	-	S	ko:K06374	-	ko00000	Spore maturation protein
HMBIOMIE_00821	4.45e-169	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HMBIOMIE_00822	1.5e-128	resA	-	-	CO	-	-	-	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
HMBIOMIE_00823	0.0	resB	-	-	O	ko:K07399	-	ko00000	COG1333 ResB protein required for cytochrome c biosynthesis
HMBIOMIE_00824	4.67e-279	resC	-	-	O	-	-	-	'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
HMBIOMIE_00825	1.69e-171	resD	-	-	T	ko:K07775	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_00826	0.0	resE	2.7.13.3	-	T	ko:K07651	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_00827	1.08e-133	sigX	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_00828	2.7e-257	rsiX	-	-	-	-	-	-	-
HMBIOMIE_00829	2.89e-175	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
HMBIOMIE_00830	0.0	serA	1.1.1.399, 1.1.1.95	-	E	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMBIOMIE_00831	3.07e-122	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMBIOMIE_00832	8.35e-55	fer	-	-	C	ko:K05337	-	ko00000	Ferredoxin
HMBIOMIE_00833	5.67e-258	ypbB	5.1.3.1	-	S	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	protein conserved in bacteria
HMBIOMIE_00834	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
HMBIOMIE_00835	6.13e-129	ypbD	-	-	S	ko:K07052	-	ko00000	metal-dependent membrane protease
HMBIOMIE_00836	5.04e-148	ypbE	-	-	M	-	-	-	Lysin motif
HMBIOMIE_00837	1.42e-106	ypbF	-	-	S	-	-	-	Protein of unknown function (DUF2663)
HMBIOMIE_00838	4.33e-188	ypbG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
HMBIOMIE_00839	5.56e-136	mecB	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HMBIOMIE_00840	1.42e-308	gudB	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
HMBIOMIE_00841	1.62e-227	ypdA	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	COG0492 Thioredoxin reductase
HMBIOMIE_00842	4.33e-154	prsW	-	-	S	-	-	-	Involved in the degradation of specific anti-sigma factors
HMBIOMIE_00843	4.88e-208	sleB	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Spore cortex-lytic enzyme
HMBIOMIE_00844	0.0	ypeB	-	-	H	ko:K06313	-	ko00000	sporulation protein
HMBIOMIE_00845	4.63e-144	ypfA	-	-	M	-	-	-	Flagellar protein YcgR
HMBIOMIE_00846	1.74e-32	-	-	-	S	-	-	-	Family of unknown function (DUF5359)
HMBIOMIE_00847	1.73e-147	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
HMBIOMIE_00848	9.5e-263	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
HMBIOMIE_00849	8.41e-238	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HMBIOMIE_00850	1.13e-11	-	-	-	S	-	-	-	YpzI-like protein
HMBIOMIE_00851	2.73e-134	yphA	-	-	-	-	-	-	-
HMBIOMIE_00852	4.35e-207	yphB	-	-	S	ko:K05739	-	ko00000	YIEGIA protein
HMBIOMIE_00853	8.69e-40	ypzH	-	-	-	-	-	-	-
HMBIOMIE_00854	4.77e-316	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
HMBIOMIE_00855	2.01e-243	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
HMBIOMIE_00856	7.09e-27	yphE	-	-	S	-	-	-	Protein of unknown function (DUF2768)
HMBIOMIE_00857	9.07e-178	yphF	-	-	-	-	-	-	-
HMBIOMIE_00858	0.0	spoIVA	-	-	S	ko:K06398	-	ko00000	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HMBIOMIE_00859	1.07e-57	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HMBIOMIE_00860	4.41e-131	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
HMBIOMIE_00861	5.13e-46	mtrB	-	-	K	ko:K06285	-	ko00000,ko03000	Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
HMBIOMIE_00862	8.72e-178	hepS	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
HMBIOMIE_00863	1.34e-169	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
HMBIOMIE_00864	4.09e-249	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HMBIOMIE_00865	2.17e-104	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
HMBIOMIE_00866	3.69e-183	cheR	2.1.1.80	-	NT	ko:K00575	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko01000,ko02035	COG1352 Methylase of chemotaxis methyl-accepting proteins
HMBIOMIE_00867	1.44e-277	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMBIOMIE_00868	8.48e-265	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMBIOMIE_00869	9.82e-84	aroH	5.4.99.5	-	E	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
HMBIOMIE_00870	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMBIOMIE_00871	6.08e-230	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMBIOMIE_00872	4.18e-145	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
HMBIOMIE_00873	2.82e-153	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
HMBIOMIE_00874	9.33e-295	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HMBIOMIE_00875	3.82e-186	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HMBIOMIE_00876	4.5e-259	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMBIOMIE_00877	1.71e-264	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
HMBIOMIE_00878	9.91e-302	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
HMBIOMIE_00879	5.27e-299	ypiA	-	-	S	-	-	-	COG0457 FOG TPR repeat
HMBIOMIE_00880	1.29e-129	ypiB	-	-	S	-	-	-	Belongs to the UPF0302 family
HMBIOMIE_00881	4.75e-101	ypiF	-	-	S	-	-	-	Protein of unknown function (DUF2487)
HMBIOMIE_00882	3.35e-126	qcrA	-	-	C	ko:K03886	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Menaquinol-cytochrome c reductase
HMBIOMIE_00883	8.76e-166	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
HMBIOMIE_00884	5.71e-191	qcrC	-	-	C	ko:K03888	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	Menaquinol-cytochrome c reductase cytochrome b c subunit
HMBIOMIE_00885	2.82e-126	ypjA	-	-	S	-	-	-	membrane
HMBIOMIE_00886	6.84e-183	ypjB	-	-	S	-	-	-	sporulation protein
HMBIOMIE_00887	3.7e-200	ypjC	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
HMBIOMIE_00888	5.83e-73	ypjD	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
HMBIOMIE_00889	2.4e-189	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HMBIOMIE_00890	1.52e-94	mgsA	4.2.3.3	-	G	ko:K01734	ko00640,ko01120,map00640,map01120	ko00000,ko00001,ko01000	methylglyoxal synthase
HMBIOMIE_00891	6.61e-167	bshB1	-	-	S	ko:K01463	-	ko00000,ko01000	proteins, LmbE homologs
HMBIOMIE_00892	1.04e-268	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
HMBIOMIE_00893	1.41e-283	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HMBIOMIE_00894	4.87e-234	birA	6.3.4.15	-	K	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HMBIOMIE_00895	4.85e-194	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
HMBIOMIE_00896	1.34e-200	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HMBIOMIE_00897	4.16e-85	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HMBIOMIE_00898	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
HMBIOMIE_00899	1.52e-32	ypmA	-	-	S	-	-	-	Protein of unknown function (DUF4264)
HMBIOMIE_00900	2.27e-103	ypmB	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00901	1.07e-285	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
HMBIOMIE_00902	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	asparaginyl-tRNA
HMBIOMIE_00903	6.62e-165	dnaD	-	-	L	ko:K02086	-	ko00000	DNA replication protein DnaD
HMBIOMIE_00904	3.57e-158	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMBIOMIE_00905	1.43e-121	ypoC	-	-	-	-	-	-	-
HMBIOMIE_00906	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HMBIOMIE_00907	3.2e-150	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HMBIOMIE_00908	4.54e-241	yppC	-	-	S	-	-	-	Protein of unknown function (DUF2515)
HMBIOMIE_00911	7.9e-10	yppE	-	-	S	-	-	-	Bacterial domain of unknown function (DUF1798)
HMBIOMIE_00912	9.21e-11	-	-	-	S	-	-	-	YppF-like protein
HMBIOMIE_00913	8.72e-68	yppG	-	-	S	-	-	-	YppG-like protein
HMBIOMIE_00914	4.33e-95	hspX	-	-	O	ko:K06335,ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HMBIOMIE_00915	2.22e-111	ypqE	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
HMBIOMIE_00916	0.0	yprA	-	-	L	ko:K06877	-	ko00000	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
HMBIOMIE_00917	7.21e-301	yprB	-	-	L	ko:K07502	-	ko00000	RNase_H superfamily
HMBIOMIE_00918	3.41e-130	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
HMBIOMIE_00919	2.97e-60	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HMBIOMIE_00920	2.84e-286	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
HMBIOMIE_00922	0.0	ypvA	3.6.4.12	-	KL	ko:K03722	-	ko00000,ko01000,ko03400	COG1199 Rad3-related DNA helicases
HMBIOMIE_00923	2.05e-179	kduD	1.1.1.127	-	IQ	ko:K00065	ko00040,map00040	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_00924	1.25e-204	kduI	5.3.1.17	-	G	ko:K01815	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HMBIOMIE_00925	1.92e-238	kdgR	-	-	K	ko:K02525	-	ko00000,ko03000	transcriptional
HMBIOMIE_00926	6.95e-238	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
HMBIOMIE_00927	2.53e-133	kdgA	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	2-dehydro-3-deoxy-phosphogluconate aldolase
HMBIOMIE_00928	5.8e-224	kdgT	-	-	P	ko:K02526	-	ko00000,ko02000	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
HMBIOMIE_00929	0.0	ypwA	3.4.17.19	-	E	ko:K01299	-	ko00000,ko01000,ko01002	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HMBIOMIE_00930	8.16e-129	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HMBIOMIE_00931	3.14e-294	pbuX	-	-	F	ko:K03458,ko:K16169,ko:K16170	-	ko00000,ko02000	xanthine
HMBIOMIE_00932	4.55e-266	bcsA	-	-	Q	ko:K16167	-	ko00000,ko01008	Naringenin-chalcone synthase
HMBIOMIE_00933	3.33e-113	ypbQ	-	-	S	ko:K16168	-	ko00000,ko01008	protein conserved in bacteria
HMBIOMIE_00934	0.0	ypbR	-	-	S	-	-	-	Dynamin family
HMBIOMIE_00935	4.07e-52	ypbS	-	-	S	-	-	-	Protein of unknown function (DUF2533)
HMBIOMIE_00936	1.08e-11	-	-	-	-	-	-	-	-
HMBIOMIE_00937	2.26e-213	ypcP	-	-	L	-	-	-	5'3' exonuclease
HMBIOMIE_00938	5.23e-05	-	-	-	-	ko:K06429	-	ko00000	-
HMBIOMIE_00939	1.6e-89	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease
HMBIOMIE_00940	2.4e-138	ypdP	-	-	S	ko:K09125	-	ko00000	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HMBIOMIE_00941	4e-163	ypeP	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	COG0328 Ribonuclease HI
HMBIOMIE_00942	7.99e-41	ypeQ	-	-	S	-	-	-	Zinc-finger
HMBIOMIE_00943	1.05e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF2564)
HMBIOMIE_00944	1.17e-22	degR	-	-	-	-	-	-	-
HMBIOMIE_00945	2.54e-42	cspD	-	-	K	ko:K03704	-	ko00000,ko03000	Cold-shock protein
HMBIOMIE_00946	1.28e-276	ugtP	2.4.1.315	GT28	M	ko:K03429	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
HMBIOMIE_00947	1.28e-226	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMBIOMIE_00948	1.89e-115	bsaA	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
HMBIOMIE_00949	2.52e-142	yagB	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
HMBIOMIE_00950	8.52e-206	ypgR	-	-	C	-	-	-	COG0694 Thioredoxin-like proteins and domains
HMBIOMIE_00951	0.0	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
HMBIOMIE_00952	9.69e-99	yphP	-	-	S	-	-	-	Belongs to the UPF0403 family
HMBIOMIE_00953	6.15e-187	ypiP	-	-	AJ	-	-	-	Putative SAM-dependent methyltransferase
HMBIOMIE_00954	3.47e-148	ypjP	-	-	S	-	-	-	YpjP-like protein
HMBIOMIE_00955	8.91e-121	ltrC	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
HMBIOMIE_00956	1.03e-202	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMBIOMIE_00957	9.58e-122	dfrA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMBIOMIE_00958	8.12e-144	ypkP	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HMBIOMIE_00959	8.03e-143	yplQ	-	-	S	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
HMBIOMIE_00960	1.4e-236	yplP	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_00961	1.73e-308	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMBIOMIE_00962	1.28e-54	ypmP	-	-	S	-	-	-	Protein of unknown function (DUF2535)
HMBIOMIE_00963	3.23e-139	ypmQ	-	-	S	ko:K07152	-	ko00000,ko03029	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
HMBIOMIE_00964	1.05e-177	ypmR	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HMBIOMIE_00965	6.8e-129	ypmS	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00966	2.13e-40	ypmT	-	-	S	-	-	-	Uncharacterized ympT
HMBIOMIE_00967	1.65e-288	mepA	-	-	V	-	-	-	MATE efflux family protein
HMBIOMIE_00968	4.14e-94	ypoP	-	-	K	-	-	-	transcriptional
HMBIOMIE_00969	9.83e-133	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMBIOMIE_00970	7.13e-103	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
HMBIOMIE_00971	1.66e-157	-	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
HMBIOMIE_00972	1.1e-277	phy	3.1.3.8	-	I	ko:K01083	ko00562,map00562	ko00000,ko00001,ko01000	Myo-inositol-hexaphosphate 3-phosphohydrolase
HMBIOMIE_00973	3.86e-236	cgeB	-	-	S	ko:K06320	-	ko00000	Spore maturation protein
HMBIOMIE_00974	1.12e-85	cgeA	-	-	-	ko:K06319	-	ko00000	-
HMBIOMIE_00975	3.04e-59	cgeC	-	-	-	ko:K06321	-	ko00000	-
HMBIOMIE_00976	0.0	cgeD	-	-	M	ko:K06322	-	ko00000	maturation of the outermost layer of the spore
HMBIOMIE_00977	9.39e-183	yiiD	-	-	K	ko:K06323	-	ko00000	acetyltransferase
HMBIOMIE_00979	0.0	yodT	-	-	H	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMBIOMIE_00980	3.41e-161	atoD	2.8.3.8, 2.8.3.9	-	I	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMBIOMIE_00981	5.46e-152	atoA	2.8.3.8, 2.8.3.9	-	I	ko:K01035	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HMBIOMIE_00982	0.0	yodQ	3.5.1.16, 3.5.1.18	-	E	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetylornithine deacetylase
HMBIOMIE_00983	1.84e-197	yodP	2.3.1.264	-	K	ko:K21935	-	ko00000,ko01000	Acetyltransferase (GNAT) family
HMBIOMIE_00984	1.36e-251	kamA	5.4.3.2	-	E	ko:K01843	ko00310,map00310	ko00000,ko00001,ko01000	lysine 2,3-aminomutase
HMBIOMIE_00985	0.0	-	-	-	S	-	-	-	Recombinase
HMBIOMIE_00986	7.89e-105	-	-	-	S	ko:K03824	-	ko00000,ko01000	family acetyltransferase
HMBIOMIE_00987	8.25e-168	yokF	3.1.31.1	-	L	ko:K01174	-	ko00000,ko01000	RNA catabolic process
HMBIOMIE_00988	7.77e-45	-	-	-	-	-	-	-	-
HMBIOMIE_00989	7.26e-116	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
HMBIOMIE_00990	0.0	ybaR	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
HMBIOMIE_00992	3.47e-205	ybaS	-	-	S	-	-	-	Na -dependent transporter
HMBIOMIE_00993	1.71e-157	ybbA	-	-	S	ko:K07017	-	ko00000	Putative esterase
HMBIOMIE_00994	3.51e-228	feuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_00995	2.88e-226	feuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_00996	9.23e-219	feuA	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Iron-uptake system-binding protein
HMBIOMIE_00997	0.0	ybbB	-	-	K	ko:K21701	-	ko00000,ko03000	COG2207 AraC-type DNA-binding domain-containing proteins
HMBIOMIE_00998	3.6e-306	ybbC	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_00999	0.0	ybbD	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
HMBIOMIE_01000	0.0	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the UPF0214 family
HMBIOMIE_01001	7.29e-304	ybbF	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_01002	3.82e-194	ybbH	-	-	K	-	-	-	transcriptional
HMBIOMIE_01003	4.04e-211	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HMBIOMIE_01004	1.55e-114	ybbJ	-	-	J	-	-	-	acetyltransferase
HMBIOMIE_01005	4.19e-101	ybbK	-	-	S	-	-	-	Protein of unknown function (DUF523)
HMBIOMIE_01011	1.6e-127	sigW	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_01012	2.73e-152	rsiW	-	-	K	-	-	-	Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
HMBIOMIE_01013	5.43e-189	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMBIOMIE_01014	4.16e-292	ybbR	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01015	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMBIOMIE_01016	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HMBIOMIE_01017	3.67e-227	alkA	3.2.2.21	-	L	ko:K01247,ko:K13529	ko03410,map03410	ko00000,ko00001,ko01000,ko03000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HMBIOMIE_01018	2.25e-157	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
HMBIOMIE_01019	4.49e-130	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMBIOMIE_01020	0.0	ndhF	1.6.5.3	-	CP	ko:K05577	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HMBIOMIE_01021	0.0	ybcC	-	-	S	ko:K09822	-	ko00000	Belongs to the UPF0753 family
HMBIOMIE_01022	2.51e-125	ybcF	-	-	P	-	-	-	carbonic anhydrase
HMBIOMIE_01023	5.59e-64	-	-	-	-	-	-	-	-
HMBIOMIE_01024	3.6e-80	ybcI	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2294)
HMBIOMIE_01025	9.45e-67	-	-	-	K	-	-	-	Helix-turn-helix domain
HMBIOMIE_01026	1.14e-258	ybcL	-	-	EGP	ko:K08164	-	ko00000,ko02000	COG2814 Arabinose efflux permease
HMBIOMIE_01028	7.24e-304	-	-	-	J	-	-	-	4Fe-4S single cluster domain
HMBIOMIE_01029	0.0	-	-	-	V	ko:K07052	-	ko00000	CAAX protease self-immunity
HMBIOMIE_01030	8.07e-174	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HMBIOMIE_01031	3.99e-313	skfF	-	-	S	-	-	-	ABC transporter
HMBIOMIE_01032	3.88e-118	-	-	-	C	-	-	-	HEAT repeats
HMBIOMIE_01033	5.88e-103	-	-	-	CO	-	-	-	Thioredoxin-like domain
HMBIOMIE_01034	2.31e-232	-	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMBIOMIE_01035	1.39e-157	-	-	-	T	ko:K02483	-	ko00000,ko02022	Transcriptional regulatory protein, C terminal
HMBIOMIE_01036	4.22e-214	-	-	-	T	-	-	-	His Kinase A (phospho-acceptor) domain
HMBIOMIE_01038	1.68e-179	ybdM	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	Protein tyrosine kinase
HMBIOMIE_01039	3.67e-193	ybdN	-	-	-	-	-	-	-
HMBIOMIE_01040	8.98e-274	ybdO	-	-	S	-	-	-	Domain of unknown function (DUF4885)
HMBIOMIE_01041	0.0	ybxG	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_01042	5.46e-51	csgA	-	-	S	-	-	-	Sigma-G-dependent sporulation-specific SASP protein
HMBIOMIE_01043	6.92e-41	ybxH	-	-	S	-	-	-	Family of unknown function (DUF5370)
HMBIOMIE_01044	3.86e-195	ybxI	3.5.2.6	-	V	ko:K17838	ko01501,map01501	ko00000,ko00001,ko01000	beta-lactamase
HMBIOMIE_01045	9.97e-317	cypC	1.11.2.4	-	Q	ko:K15629	-	ko00000,ko00199,ko01000	Cytochrome P450
HMBIOMIE_01046	1.11e-54	ybyB	-	-	-	-	-	-	-
HMBIOMIE_01047	0.0	ybeC	-	-	E	-	-	-	amino acid
HMBIOMIE_01048	7.3e-213	glpQ	3.1.3.1, 3.1.4.46	-	C	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	glycerophosphoryl diester phosphodiesterase
HMBIOMIE_01049	0.0	glpT	-	-	G	ko:K02445	-	ko00000,ko02000	-transporter
HMBIOMIE_01050	3.57e-47	-	-	-	S	-	-	-	Protein of unknown function (DUF2651)
HMBIOMIE_01051	8.93e-220	ybfA	-	-	K	-	-	-	FR47-like protein
HMBIOMIE_01052	2.36e-287	ybfB	-	-	G	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_01054	0.0	ybfG	-	-	M	-	-	-	Domain of unknown function (DUF1906)
HMBIOMIE_01055	1.51e-207	ybfH	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_01056	7.39e-188	ybfI	-	-	K	-	-	-	AraC-like ligand binding domain
HMBIOMIE_01057	1.95e-272	purT	2.1.2.2	-	F	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HMBIOMIE_01058	1.14e-226	mpr	-	-	M	-	-	-	Belongs to the peptidase S1B family
HMBIOMIE_01060	4.76e-215	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HMBIOMIE_01061	5.67e-123	pssA	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMBIOMIE_01062	7.07e-112	ybfM	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_01063	6.15e-190	psd	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
HMBIOMIE_01064	2.25e-59	ybfN	-	-	-	-	-	-	-
HMBIOMIE_01065	0.0	-	-	-	S	ko:K06880	-	ko00000,ko01000,ko01504	Erythromycin esterase
HMBIOMIE_01066	5.14e-214	ybfP	-	-	K	ko:K13653	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01067	1.16e-244	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
HMBIOMIE_01068	6.04e-273	gltP	-	-	C	ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMBIOMIE_01069	0.0	ptsG	2.7.1.199	-	G	ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_01070	7.72e-177	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HMBIOMIE_01071	2.91e-165	-	-	-	K	ko:K03710,ko:K10711	-	ko00000,ko03000	UTRA
HMBIOMIE_01073	3.08e-259	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
HMBIOMIE_01074	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HMBIOMIE_01075	2.23e-234	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine
HMBIOMIE_01076	0.0	agcS	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
HMBIOMIE_01077	1.02e-233	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
HMBIOMIE_01078	2.91e-293	glnJ	2.7.13.3	-	T	ko:K07717	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_01079	1.41e-216	glnL	-	-	T	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Regulator
HMBIOMIE_01080	4.1e-222	ycbC	4.2.1.41	-	EM	ko:K01707	ko00053,ko01100,map00053,map01100	ko00000,ko00001,ko01000	5-dehydro-4-deoxyglucarate dehydratase activity
HMBIOMIE_01081	0.0	ycbD	-	-	C	ko:K22187	ko00040,map00040	ko00000,ko00001,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMBIOMIE_01082	0.0	gudP	-	-	G	ko:K03535,ko:K08191	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_01083	0.0	gudD	4.2.1.40	-	M	ko:K01706	ko00053,ko01100,map00053,map01100	ko00000,ko00001,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HMBIOMIE_01084	2.3e-161	ycbG	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
HMBIOMIE_01085	0.0	garD	4.2.1.42, 4.2.1.7	-	G	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
HMBIOMIE_01086	4.64e-227	ycbJ	-	-	S	ko:K06979	-	br01600,ko00000,ko00002,ko01504	Macrolide 2'-phosphotransferase
HMBIOMIE_01087	8.73e-33	rtpA	-	-	K	-	-	-	Tryptophan RNA-binding attenuator protein inhibitory protein
HMBIOMIE_01088	1.87e-220	eamA1	-	-	EG	-	-	-	spore germination
HMBIOMIE_01089	6.64e-162	ycbL	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_01090	7.57e-215	ycbM	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_01091	1.07e-212	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01092	1.36e-146	-	-	-	S	-	-	-	ABC-2 family transporter protein
HMBIOMIE_01093	5.22e-75	ycbP	-	-	S	-	-	-	Protein of unknown function (DUF2512)
HMBIOMIE_01094	5.22e-102	cwlJ	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell wall
HMBIOMIE_01095	1.56e-173	ycbR	-	-	T	-	-	-	vWA found in TerF C terminus
HMBIOMIE_01096	0.0	phoD	3.1.3.1	-	P	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG3540 Phosphodiesterase alkaline phosphatase D
HMBIOMIE_01097	3.12e-38	tatAD	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HMBIOMIE_01098	3.61e-158	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMBIOMIE_01099	1.99e-153	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMBIOMIE_01100	1.45e-260	ycbU	-	-	E	-	-	-	Selenocysteine lyase
HMBIOMIE_01101	1.24e-302	lmrB	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	the major facilitator superfamily
HMBIOMIE_01102	1.54e-130	lmrA	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
HMBIOMIE_01103	1.69e-257	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
HMBIOMIE_01104	1.63e-146	-	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HMBIOMIE_01105	4.32e-78	-	-	-	S	-	-	-	RDD family
HMBIOMIE_01106	2.49e-255	yccF	-	-	K	ko:K07039	-	ko00000	SEC-C motif
HMBIOMIE_01107	9.56e-217	natK	2.7.13.3	-	T	ko:K11640	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	GHKL domain
HMBIOMIE_01108	6.86e-163	natR	-	-	T	ko:K02477,ko:K11641	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HMBIOMIE_01109	5.41e-171	natA	3.6.3.7	-	CP	ko:K01990,ko:K09697	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
HMBIOMIE_01110	9.75e-258	-	-	-	CP	ko:K09696	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
HMBIOMIE_01111	5.83e-223	yccK	-	-	C	-	-	-	Aldo keto reductase
HMBIOMIE_01112	1.35e-241	ycdA	-	-	S	-	-	-	Domain of unknown function (DUF5105)
HMBIOMIE_01113	0.0	ycdB	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_01114	0.0	ycdC	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_01115	3.91e-125	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
HMBIOMIE_01116	1.42e-248	rapJ	-	-	S	ko:K06368	-	ko00000,ko01000	Response regulator aspartate phosphatase
HMBIOMIE_01117	2.39e-180	-	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_01118	0.0	malL	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
HMBIOMIE_01119	1.95e-221	adcA	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HMBIOMIE_01120	1.99e-170	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
HMBIOMIE_01121	4.63e-173	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
HMBIOMIE_01122	9.18e-242	yceB	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_01123	2.64e-141	yceC	3.5.4.33	-	T	ko:K11991	-	ko00000,ko01000,ko03016	proteins involved in stress response, homologs of TerZ and
HMBIOMIE_01124	8.9e-137	yceD	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
HMBIOMIE_01125	4.97e-138	yceE	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
HMBIOMIE_01126	4.1e-176	yceF	-	-	P	ko:K05794	-	ko00000	Protein of unknown function (DUF475)
HMBIOMIE_01127	0.0	yceG	-	-	S	-	-	-	Putative component of 'biosynthetic module'
HMBIOMIE_01128	2.96e-245	yceH	-	-	P	-	-	-	Belongs to the TelA family
HMBIOMIE_01129	2.32e-279	yceI	-	-	P	ko:K08369	-	ko00000,ko02000	Uncharacterised MFS-type transporter YbfB
HMBIOMIE_01130	1.17e-267	-	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
HMBIOMIE_01131	4.82e-61	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HMBIOMIE_01132	8.99e-293	opuAA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
HMBIOMIE_01133	2.1e-186	opuAB	-	-	P	ko:K02001	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HMBIOMIE_01134	1.16e-209	opuAC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HMBIOMIE_01135	6.87e-277	amhX	-	-	S	ko:K14665	-	ko00000,ko01000,ko01002	amidohydrolase
HMBIOMIE_01136	0.0	ycgA	-	-	S	-	-	-	Membrane
HMBIOMIE_01137	1.25e-127	ycgB	-	-	-	-	-	-	-
HMBIOMIE_01138	0.0	amyE	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	alpha-amylase
HMBIOMIE_01139	2.06e-233	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HMBIOMIE_01140	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
HMBIOMIE_01141	0.0	mdr	-	-	EGP	-	-	-	the major facilitator superfamily
HMBIOMIE_01142	3.7e-101	ycgE	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_01143	6.42e-147	ycgF	-	-	E	-	-	-	Lysine exporter protein LysE YggA
HMBIOMIE_01144	1.85e-195	yqcI	-	-	S	ko:K09190	-	ko00000	YqcI/YcgG family
HMBIOMIE_01145	9.32e-317	ycgH	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_01146	7.6e-145	ycgI	-	-	S	ko:K09967	-	ko00000	Domain of unknown function (DUF1989)
HMBIOMIE_01147	5.24e-191	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HMBIOMIE_01148	1.26e-138	tmrB	-	-	S	-	-	-	AAA domain
HMBIOMIE_01150	8.64e-136	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMBIOMIE_01151	1.76e-184	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
HMBIOMIE_01152	1.33e-226	ycgK	-	-	K	ko:K04761	ko02026,map02026	ko00000,ko00001,ko03000	LysR substrate binding domain
HMBIOMIE_01153	4.48e-231	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
HMBIOMIE_01154	7.76e-187	ycgL	-	-	S	ko:K07074	-	ko00000	Predicted nucleotidyltransferase
HMBIOMIE_01155	3.63e-218	ycgM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
HMBIOMIE_01156	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
HMBIOMIE_01157	2.64e-316	putP	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMBIOMIE_01158	3.92e-288	ycgP	-	-	QT	-	-	-	COG2508 Regulator of polyketide synthase expression
HMBIOMIE_01159	7.72e-195	ycgQ	-	-	S	ko:K08986	-	ko00000	membrane
HMBIOMIE_01160	5.28e-186	ycgR	-	-	S	ko:K07089	-	ko00000	permeases
HMBIOMIE_01161	3.44e-202	ycgS	-	-	I	-	-	-	alpha/beta hydrolase fold
HMBIOMIE_01162	1.58e-240	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
HMBIOMIE_01163	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
HMBIOMIE_01164	1.2e-74	nasE	1.7.1.15	-	P	ko:K00363	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite reductase
HMBIOMIE_01165	0.0	nasD	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMBIOMIE_01166	0.0	nasC	-	-	C	ko:K00372	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMBIOMIE_01167	0.0	nasB	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Assimilatory nitrate reductase (electron transfer subunit)
HMBIOMIE_01168	5.51e-283	nasA	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
HMBIOMIE_01169	1.05e-222	folE2	3.5.4.16	-	S	ko:K09007	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Converts GTP to 7,8-dihydroneopterin triphosphate
HMBIOMIE_01170	2.56e-141	-	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
HMBIOMIE_01171	6.78e-291	yciC	-	-	S	-	-	-	GTPases (G3E family)
HMBIOMIE_01172	2.99e-149	yckA	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
HMBIOMIE_01173	3.76e-187	yckB	-	-	ET	ko:K02030,ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
HMBIOMIE_01176	5.95e-101	yckC	-	-	S	-	-	-	membrane
HMBIOMIE_01177	3.53e-69	yckD	-	-	S	-	-	-	Protein of unknown function (DUF2680)
HMBIOMIE_01178	0.0	yckE	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HMBIOMIE_01179	7.06e-93	nin	-	-	S	-	-	-	Competence protein J (ComJ)
HMBIOMIE_01180	4.78e-101	nucA	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
HMBIOMIE_01181	6.52e-269	tlpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_01182	1.38e-127	hxlB	5.3.1.27	-	G	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
HMBIOMIE_01183	2.39e-138	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	3-hexulose-6-phosphate synthase
HMBIOMIE_01184	6.05e-86	hxlR	-	-	K	-	-	-	transcriptional
HMBIOMIE_01185	0.0	srfAA	-	-	Q	ko:K15654,ko:K15655,ko:K16119	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_01186	0.0	srfAB	-	-	Q	ko:K15654,ko:K15655,ko:K16120	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_01187	0.0	srfAC	-	-	Q	ko:K15656,ko:K16121	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	COG1020 Non-ribosomal peptide synthetase modules and related proteins
HMBIOMIE_01188	1.63e-179	srfAD	-	-	Q	ko:K15657	ko02024,map02024	ko00000,ko00001,ko01008	thioesterase
HMBIOMIE_01189	1.38e-291	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HMBIOMIE_01190	1.61e-126	-	-	-	S	-	-	-	YcxB-like protein
HMBIOMIE_01191	1.77e-209	ycxC	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_01192	0.0	ycxD	-	-	K	-	-	-	GntR family transcriptional regulator
HMBIOMIE_01193	1.37e-144	sfp	-	-	H	ko:K06133	ko00770,map00770	ko00000,ko00001,ko01000	Belongs to the P-Pant transferase superfamily
HMBIOMIE_01194	3.04e-148	yczE	-	-	S	ko:K07149	-	ko00000	membrane
HMBIOMIE_01195	7.11e-172	tcyC	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
HMBIOMIE_01196	4.6e-157	tcyB	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
HMBIOMIE_01197	1.5e-188	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
HMBIOMIE_01198	9.2e-210	yclA	-	-	K	ko:K21755	-	ko00000,ko03000	LysR substrate binding domain
HMBIOMIE_01199	2.33e-142	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
HMBIOMIE_01200	0.0	yclC	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182,ko:K16874	ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
HMBIOMIE_01201	9.86e-53	-	4.1.1.61	-	S	ko:K21759	ko00627,ko01120,ko01220,map00627,map01120,map01220	ko00000,ko00001,ko01000	response to toxic substance
HMBIOMIE_01202	3.05e-109	yclD	-	-	-	-	-	-	-
HMBIOMIE_01203	5.12e-207	yclE	3.4.11.5	-	S	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Alpha beta hydrolase
HMBIOMIE_01204	0.0	dtpT	-	-	E	ko:K03305	-	ko00000	amino acid peptide transporter
HMBIOMIE_01205	0.0	yclG	-	-	M	-	-	-	Pectate lyase superfamily protein
HMBIOMIE_01207	0.0	gerKA	-	-	EG	ko:K06295,ko:K06307	-	ko00000	Spore germination protein
HMBIOMIE_01208	8.35e-297	gerKC	-	-	S	ko:K06297	-	ko00000	spore germination
HMBIOMIE_01209	2.29e-254	gerKB	-	-	F	ko:K06296	-	ko00000,ko02000	Spore germination protein
HMBIOMIE_01210	2.05e-156	yclH	-	-	P	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HMBIOMIE_01211	5.59e-280	yclI	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease) YclI
HMBIOMIE_01212	2.23e-165	yclJ	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_01213	0.0	yclK	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HMBIOMIE_01214	2.18e-97	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
HMBIOMIE_01216	6.5e-05	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
HMBIOMIE_01217	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HMBIOMIE_01218	5.42e-206	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_01219	4.69e-211	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_01220	5.63e-176	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01221	4.98e-223	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4607 ABC-type enterochelin transport system, periplasmic component
HMBIOMIE_01222	0.0	ycnB	-	-	EGP	-	-	-	the major facilitator superfamily
HMBIOMIE_01223	2.91e-198	ycnC	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01224	2.12e-174	-	1.5.1.39	-	C	ko:K10678,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	ko00000,ko00001,ko01000	Oxidoreductase
HMBIOMIE_01225	1.68e-60	ycnE	-	-	S	-	-	-	Monooxygenase
HMBIOMIE_01226	6.51e-69	yczG	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HMBIOMIE_01227	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_01228	7.68e-310	gabT	2.6.1.19, 2.6.1.22	-	E	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMBIOMIE_01229	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMBIOMIE_01230	3.37e-190	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	Glucose uptake
HMBIOMIE_01231	5.9e-187	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_01232	3.05e-138	ycnI	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01233	0.0	ycnJ	-	-	P	ko:K14166	-	ko00000,ko02000	protein, homolog of Cu resistance protein CopC
HMBIOMIE_01234	5.18e-139	ycnK	-	-	K	ko:K21601	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
HMBIOMIE_01235	1.34e-74	-	-	-	-	-	-	-	-
HMBIOMIE_01236	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
HMBIOMIE_01237	8.3e-95	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
HMBIOMIE_01238	3.77e-269	mtlD	1.1.1.17	-	G	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	COG0246 Mannitol-1-phosphate altronate dehydrogenases
HMBIOMIE_01239	1.01e-256	ycsA	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Tartrate dehydrogenase
HMBIOMIE_01241	6.21e-97	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HMBIOMIE_01242	2.64e-147	-	-	-	Q	-	-	-	COG0412 Dienelactone hydrolase and related enzymes
HMBIOMIE_01243	2.29e-88	ycsD	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
HMBIOMIE_01245	1.9e-177	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
HMBIOMIE_01246	9.39e-182	ycsF	-	-	S	ko:K07160	-	ko00000	Belongs to the UPF0271 (lamB) family
HMBIOMIE_01247	2.78e-273	ycsG	-	-	P	-	-	-	COG1914 Mn2 and Fe2 transporters of the NRAMP family
HMBIOMIE_01248	7e-190	ycsI	-	-	S	-	-	-	Belongs to the D-glutamate cyclase family
HMBIOMIE_01249	5.04e-173	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
HMBIOMIE_01250	1.99e-238	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
HMBIOMIE_01251	3.8e-171	kipR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01252	4.18e-154	ycsK	-	-	E	-	-	-	anatomical structure formation involved in morphogenesis
HMBIOMIE_01254	7.67e-66	yczJ	-	-	S	-	-	-	biosynthesis
HMBIOMIE_01255	0.0	pbpC	3.4.16.4	-	M	ko:K02545,ko:K21467	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	Penicillin-binding Protein
HMBIOMIE_01256	3.26e-224	ycsN	-	-	S	-	-	-	Oxidoreductase
HMBIOMIE_01257	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	transcriptional regulator, MtlR
HMBIOMIE_01258	0.0	ydaB	-	-	IQ	-	-	-	acyl-CoA ligase
HMBIOMIE_01259	6.05e-129	ydaC	-	-	Q	-	-	-	Methyltransferase domain
HMBIOMIE_01260	3.74e-207	ydaD	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_01261	2.36e-126	ydaE	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Cupin 2, conserved barrel domain protein
HMBIOMIE_01262	6.6e-134	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMBIOMIE_01263	5.24e-101	ydaG	-	-	S	-	-	-	general stress protein
HMBIOMIE_01264	1.31e-178	amj	-	-	U	-	-	-	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
HMBIOMIE_01265	1.88e-62	ydzA	-	-	EGP	-	-	-	Domain of unknown function (DUF3817)
HMBIOMIE_01266	3.95e-98	lrpC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
HMBIOMIE_01267	0.0	topB	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMBIOMIE_01268	3.08e-267	ydaJ	-	-	M	-	-	-	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HMBIOMIE_01269	1.14e-195	ydaK	-	-	T	-	-	-	Diguanylate cyclase, GGDEF domain
HMBIOMIE_01270	0.0	ydaL	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2334)
HMBIOMIE_01271	1.93e-304	ydaM	-	-	M	-	-	-	Glycosyl transferase family group 2
HMBIOMIE_01272	0.0	ydaN	-	-	S	-	-	-	Bacterial cellulose synthase subunit
HMBIOMIE_01273	0.0	ydaO	-	-	E	-	-	-	amino acid
HMBIOMIE_01274	3.75e-103	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
HMBIOMIE_01275	0.0	ydaP	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HMBIOMIE_01276	2.14e-53	-	-	-	-	-	-	-	-
HMBIOMIE_01277	3.9e-286	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HMBIOMIE_01278	1.67e-42	ydaS	-	-	S	-	-	-	membrane
HMBIOMIE_01279	2.25e-100	ydaT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
HMBIOMIE_01280	1.06e-190	ydbA	-	-	P	-	-	-	EcsC protein family
HMBIOMIE_01281	8.37e-11	gsiB	-	-	S	ko:K06884	-	ko00000	general stress protein
HMBIOMIE_01282	7.58e-79	ydbB	-	-	G	-	-	-	Cupin domain
HMBIOMIE_01283	5.41e-84	ydbC	-	-	S	-	-	-	Domain of unknown function (DUF4937
HMBIOMIE_01284	1.35e-198	ydbD	-	-	P	ko:K07217	-	ko00000	Catalase
HMBIOMIE_01285	3.66e-253	dctB	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
HMBIOMIE_01286	0.0	dctS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
HMBIOMIE_01287	3.39e-155	dctR	-	-	T	ko:K02475,ko:K11692	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
HMBIOMIE_01288	4.43e-290	dctA	-	-	U	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMBIOMIE_01289	3.25e-231	ydbI	-	-	S	-	-	-	AI-2E family transporter
HMBIOMIE_01290	2.28e-219	ydbJ	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01291	7.34e-160	ydbK	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMBIOMIE_01292	9.32e-70	ydbL	-	-	-	-	-	-	-
HMBIOMIE_01293	1.83e-280	ydbM	-	-	I	-	-	-	acyl-CoA dehydrogenase
HMBIOMIE_01294	1.49e-26	-	-	-	S	-	-	-	Fur-regulated basic protein B
HMBIOMIE_01296	1.91e-202	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMBIOMIE_01297	4.19e-75	ydbP	-	-	CO	-	-	-	Thioredoxin
HMBIOMIE_01298	3.07e-258	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
HMBIOMIE_01299	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HMBIOMIE_01300	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HMBIOMIE_01301	2.12e-107	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
HMBIOMIE_01302	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Membrane
HMBIOMIE_01303	2.53e-139	ydcA	-	-	S	-	-	-	membrane protein (homolog of Drosophila rhomboid)
HMBIOMIE_01304	1.95e-78	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HMBIOMIE_01305	4.66e-234	ydcC	-	-	M	-	-	-	COG2834 Outer membrane lipoprotein-sorting protein
HMBIOMIE_01306	5.29e-284	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMBIOMIE_01307	9.49e-57	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
HMBIOMIE_01308	4.34e-75	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
HMBIOMIE_01309	8.58e-184	rsbR	-	-	T	ko:K17763	-	ko00000,ko03021	Positive regulator of sigma-B
HMBIOMIE_01310	1.8e-74	rsbS	-	-	T	ko:K17762	-	ko00000,ko03021	antagonist
HMBIOMIE_01311	8.56e-90	rsbT	2.7.11.1	-	T	ko:K17752	-	ko00000,ko01000,ko01001,ko03021	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
HMBIOMIE_01312	1.31e-243	rsbU	3.1.3.3	-	KT	ko:K07315	-	ko00000,ko01000,ko03021	phosphatase
HMBIOMIE_01313	1.97e-70	rsbV	-	-	T	ko:K04749	-	ko00000,ko03021	Belongs to the anti-sigma-factor antagonist family
HMBIOMIE_01314	2.48e-111	rsbW	2.7.11.1	-	F	ko:K04757	-	ko00000,ko01000,ko01001,ko03021	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
HMBIOMIE_01315	1.55e-178	sigB	-	-	K	ko:K03090	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_01316	1.86e-141	rsbX	3.1.3.3	-	KT	ko:K05518	-	ko00000,ko01000,ko03021	Sigma factor PP2C-like phosphatases
HMBIOMIE_01320	1.32e-106	ydcG	-	-	S	-	-	-	EVE domain
HMBIOMIE_01321	1.54e-101	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_01322	0.0	tex	-	-	K	ko:K06959	-	ko00000	COG2183 Transcriptional accessory protein
HMBIOMIE_01323	1.93e-110	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
HMBIOMIE_01331	2.43e-241	-	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_01332	8.15e-94	lrpA	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	transcriptional
HMBIOMIE_01333	1.26e-101	lrpB	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	transcriptional
HMBIOMIE_01334	1.62e-128	yddQ	-	-	Q	-	-	-	Isochorismatase family
HMBIOMIE_01335	1.34e-184	yddR	-	-	S	-	-	-	Zn-dependent hydrolases of the beta-lactamase fold
HMBIOMIE_01336	3.35e-288	ydeG3	-	-	EGP	-	-	-	Major Facilitator Superfamily
HMBIOMIE_01340	0.0	dacC	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
HMBIOMIE_01341	7.83e-240	yoxA	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
HMBIOMIE_01342	9.8e-313	yoeA	-	-	V	-	-	-	MATE efflux family protein
HMBIOMIE_01343	7.14e-128	yoeB	-	-	S	-	-	-	IseA DL-endopeptidase inhibitor
HMBIOMIE_01345	1.14e-124	-	-	-	L	-	-	-	Integrase
HMBIOMIE_01346	3.31e-47	yoeD	-	-	G	-	-	-	Helix-turn-helix domain
HMBIOMIE_01347	0.0	ggt	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
HMBIOMIE_01348	1.3e-202	gltR1	-	-	K	ko:K21959	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01349	7.23e-238	yogA	-	-	C	ko:K13955	-	ko00000	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
HMBIOMIE_01350	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
HMBIOMIE_01351	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase
HMBIOMIE_01352	2.61e-205	gltC	-	-	K	ko:K09681	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01353	8.13e-263	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMBIOMIE_01354	2.72e-185	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMBIOMIE_01355	5.37e-79	rtp	-	-	K	-	-	-	Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
HMBIOMIE_01356	7.94e-160	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_01357	8.39e-57	yoxC	-	-	S	-	-	-	Bacterial protein of unknown function (DUF948)
HMBIOMIE_01358	1.34e-185	yoxB	-	-	-	-	-	-	-
HMBIOMIE_01359	5.91e-125	yoaA	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMBIOMIE_01360	1.11e-300	yoaB	-	-	EGP	-	-	-	the major facilitator superfamily
HMBIOMIE_01361	0.0	lsrK	2.7.1.189	-	G	ko:K11216	ko02024,map02024	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
HMBIOMIE_01362	3.41e-243	yoaD	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMBIOMIE_01363	0.0	yoaE	-	-	C	-	-	-	belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMBIOMIE_01364	2.08e-44	yoaF	-	-	-	-	-	-	-
HMBIOMIE_01366	1.25e-20	-	-	-	-	-	-	-	-
HMBIOMIE_01367	8.23e-62	-	-	-	S	-	-	-	Protein of unknown function (DUF4025)
HMBIOMIE_01368	0.0	yoaH	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	methyl-accepting chemotaxis protein
HMBIOMIE_01369	0.0	yoaI	1.14.14.9	-	Q	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	ko00000,ko00001,ko01000	COG2368 Aromatic ring hydroxylase
HMBIOMIE_01370	2.61e-171	yoaJ	-	-	G	ko:K20628	-	ko00000	Endoglucanase C-terminal domain subunit and related proteins
HMBIOMIE_01371	7.3e-145	yoaK	-	-	S	-	-	-	Membrane
HMBIOMIE_01372	5e-253	-	4.2.2.10	-	G	ko:K01732	-	ko00000,ko01000	Amb_all
HMBIOMIE_01373	5.08e-171	yoqW	-	-	S	-	-	-	Belongs to the SOS response-associated peptidase family
HMBIOMIE_01375	1.95e-296	oxdD	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
HMBIOMIE_01377	9.48e-188	yoaP	-	-	K	-	-	-	YoaP-like
HMBIOMIE_01378	7.38e-88	yoaQ	-	-	S	-	-	-	Evidence 4 Homologs of previously reported genes of
HMBIOMIE_01379	2.36e-116	-	-	-	-	-	-	-	-
HMBIOMIE_01380	3.63e-218	yoaR	-	-	V	-	-	-	vancomycin resistance protein
HMBIOMIE_01381	1.6e-98	yoaS	-	-	S	-	-	-	Protein of unknown function (DUF2975)
HMBIOMIE_01382	7.38e-50	yozG	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01383	6.92e-192	yoaT	-	-	S	-	-	-	Protein of unknown function (DUF817)
HMBIOMIE_01384	6.67e-203	yoaU	-	-	K	-	-	-	LysR substrate binding domain
HMBIOMIE_01385	1.11e-202	yoaV	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_01386	6.84e-103	yoaW	-	-	-	-	-	-	-
HMBIOMIE_01387	3.88e-153	lin0465	-	-	S	-	-	-	DJ-1/PfpI family
HMBIOMIE_01388	9.26e-218	penP	3.5.2.6	-	V	ko:K17836,ko:K18766	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	beta-lactamase
HMBIOMIE_01392	0.0	pps	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
HMBIOMIE_01393	1.3e-157	xlnB	3.2.1.8	-	G	ko:K01181	-	ko00000,ko01000	Glycosyl hydrolases family 11
HMBIOMIE_01394	6.27e-51	-	-	-	S	-	-	-	TM2 domain
HMBIOMIE_01395	3.92e-76	-	-	-	K	-	-	-	Helix-turn-helix
HMBIOMIE_01397	1.21e-90	yoaQ	-	-	S	-	-	-	Evidence 4 Homologs of previously reported genes of
HMBIOMIE_01398	1.92e-162	yoqW	-	-	S	-	-	-	Belongs to the SOS response-associated peptidase family
HMBIOMIE_01399	6.85e-229	-	-	-	-	-	-	-	-
HMBIOMIE_01400	1.36e-08	-	-	-	-	-	-	-	-
HMBIOMIE_01404	6.23e-267	-	-	-	S	ko:K06369	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
HMBIOMIE_01406	3.1e-103	dinB2	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_01423	2.22e-185	spo0M	-	-	S	ko:K06377	-	ko00000	COG4326 Sporulation control protein
HMBIOMIE_01424	3.88e-37	-	-	-	-	-	-	-	-
HMBIOMIE_01425	6.95e-173	ygaJ	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
HMBIOMIE_01426	0.0	thiC	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HMBIOMIE_01427	0.0	ygaK	-	-	C	-	-	-	Berberine and berberine like
HMBIOMIE_01429	0.0	katA	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
HMBIOMIE_01430	4.15e-185	ssuB	-	-	P	ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
HMBIOMIE_01431	1.78e-219	ssuA	-	-	M	ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Sulfonate ABC transporter
HMBIOMIE_01432	5.86e-190	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
HMBIOMIE_01433	9.35e-276	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
HMBIOMIE_01435	4.82e-55	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMBIOMIE_01436	2.79e-102	ygaO	-	-	-	-	-	-	-
HMBIOMIE_01437	1.48e-39	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01439	1.92e-147	yhzB	-	-	S	-	-	-	B3/4 domain
HMBIOMIE_01440	5.09e-285	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMBIOMIE_01441	4.79e-226	yhbB	-	-	S	-	-	-	Putative amidase domain
HMBIOMIE_01442	6.53e-113	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HMBIOMIE_01443	3.4e-143	yhbD	-	-	K	-	-	-	Protein of unknown function (DUF4004)
HMBIOMIE_01444	2.66e-95	yhbE	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
HMBIOMIE_01445	4.28e-105	yhbF	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
HMBIOMIE_01446	0.0	prkA	-	-	T	ko:K07180	-	ko00000	Ser protein kinase
HMBIOMIE_01447	1.21e-286	yhbH	-	-	S	ko:K09786	-	ko00000	Belongs to the UPF0229 family
HMBIOMIE_01448	1.29e-101	yhbI	-	-	K	ko:K15973	-	ko00000,ko03000	DNA-binding transcription factor activity
HMBIOMIE_01449	3.8e-133	yhbJ	-	-	V	-	-	-	COG1566 Multidrug resistance efflux pump
HMBIOMIE_01450	0.0	yhcA	-	-	EGP	ko:K03446	-	ko00000,ko00002,ko02000	the major facilitator superfamily
HMBIOMIE_01451	4.87e-128	yhcB	1.6.5.2	-	S	ko:K03809	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	Belongs to the WrbA family
HMBIOMIE_01452	3.95e-59	yhcC	-	-	-	-	-	-	-
HMBIOMIE_01453	1.67e-68	-	-	-	-	-	-	-	-
HMBIOMIE_01454	1.67e-79	yhcF	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01455	3.38e-158	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01456	6.47e-213	yhcH	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01457	3.45e-212	yhcI	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMBIOMIE_01458	1.91e-42	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	Cold-shock protein
HMBIOMIE_01459	1.34e-195	metQ_3	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HMBIOMIE_01460	2.47e-251	yhcK	2.7.7.65	-	T	ko:K18967	-	ko00000,ko01000,ko02000	COG2199 FOG GGDEF domain
HMBIOMIE_01461	2.62e-301	tcyP	-	-	U	ko:K06956	-	ko00000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMBIOMIE_01462	3.23e-80	yhcM	-	-	-	-	-	-	-
HMBIOMIE_01463	2.69e-111	yhcN	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMBIOMIE_01464	3.96e-227	yhcP	-	-	-	-	-	-	-
HMBIOMIE_01465	1.68e-146	yhcQ	-	-	M	-	-	-	Spore coat protein
HMBIOMIE_01466	0.0	yhcR	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01081,ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HMBIOMIE_01467	3.9e-138	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
HMBIOMIE_01468	8.26e-219	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HMBIOMIE_01469	4.27e-89	yhcU	-	-	S	-	-	-	Family of unknown function (DUF5365)
HMBIOMIE_01470	1.76e-90	yhcV	-	-	S	-	-	-	COG0517 FOG CBS domain
HMBIOMIE_01471	3.04e-155	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
HMBIOMIE_01472	0.0	yhcX	-	-	K	-	-	-	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HMBIOMIE_01473	0.0	yhxA	-	-	E	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMBIOMIE_01474	5.35e-135	glpP	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HMBIOMIE_01475	5.7e-196	glpF	-	-	G	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HMBIOMIE_01476	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMBIOMIE_01477	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMBIOMIE_01478	0.0	pgcA	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
HMBIOMIE_01479	2.29e-273	yhcY	2.7.13.3	-	T	ko:K02480	-	ko00000,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_01480	5.68e-148	yhcZ	-	-	K	ko:K02479	-	ko00000,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_01481	5.68e-117	yhdA	1.7.1.6	-	S	ko:K03206	-	ko00000,ko01000	NADPH-dependent FMN reductase
HMBIOMIE_01482	1.65e-51	yhdB	-	-	S	-	-	-	YhdB-like protein
HMBIOMIE_01483	1.25e-72	yhdC	-	-	S	-	-	-	Protein of unknown function (DUF3889)
HMBIOMIE_01484	1.2e-268	lytF	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
HMBIOMIE_01485	5.58e-99	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
HMBIOMIE_01486	5.04e-305	ygxB	-	-	M	-	-	-	Conserved TM helix
HMBIOMIE_01487	0.0	spoVR	-	-	S	ko:K06415	-	ko00000	Stage V sporulation protein R
HMBIOMIE_01488	0.0	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
HMBIOMIE_01489	1.05e-199	lytE	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
HMBIOMIE_01490	4.93e-210	citR	-	-	K	ko:K19242	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01491	5.51e-263	citA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
HMBIOMIE_01492	1.41e-208	yhdF	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_01493	8.94e-317	yhdG	-	-	E	ko:K03294	-	ko00000	amino acid
HMBIOMIE_01494	4.29e-310	yhdH	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HMBIOMIE_01495	0.0	ydeL	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_01496	1.75e-100	-	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_01497	4.27e-59	yhdK	-	-	S	-	-	-	Sigma-M inhibitor protein
HMBIOMIE_01498	6.13e-258	yhdL	-	-	S	-	-	-	Sigma factor regulator N-terminal
HMBIOMIE_01499	3.24e-113	sigM	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_01500	6.74e-244	yhdN	-	-	C	-	-	-	Aldo keto reductase
HMBIOMIE_01501	3.9e-143	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
HMBIOMIE_01502	2.18e-304	yhdP	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
HMBIOMIE_01503	3.44e-97	cueR	-	-	K	ko:K11923	-	ko00000,ko03000	transcriptional
HMBIOMIE_01504	4.37e-285	yhdR	2.6.1.1	-	E	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
HMBIOMIE_01505	0.0	yhdT	-	-	P	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
HMBIOMIE_01506	2.69e-70	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMBIOMIE_01507	1.01e-87	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMBIOMIE_01508	5.44e-174	yhdW	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HMBIOMIE_01509	3.7e-09	yhdX	-	-	S	-	-	-	Uncharacterized protein YhdX
HMBIOMIE_01510	4.51e-260	yhdY	-	-	M	ko:K16052	-	ko00000,ko02000	Mechanosensitive ion channel
HMBIOMIE_01511	2.93e-180	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
HMBIOMIE_01512	5.7e-200	nodB1	-	-	G	-	-	-	deacetylase
HMBIOMIE_01513	2.23e-197	dat	2.6.1.21	-	E	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	ko00000,ko00001,ko01000,ko01007	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
HMBIOMIE_01514	1.32e-305	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
HMBIOMIE_01515	3.85e-109	nhaX	-	-	T	-	-	-	Belongs to the universal stress protein A family
HMBIOMIE_01516	0.0	yheI	-	-	V	ko:K18216,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
HMBIOMIE_01517	0.0	yheH	-	-	V	ko:K06147,ko:K18217,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
HMBIOMIE_01518	3.31e-143	yheG	-	-	GM	-	-	-	NAD(P)H-binding
HMBIOMIE_01519	1.25e-38	sspB	-	-	S	ko:K06418,ko:K06419,ko:K06420	-	ko00000	spore protein
HMBIOMIE_01520	2.27e-49	yheE	-	-	S	-	-	-	Family of unknown function (DUF5342)
HMBIOMIE_01521	0.0	yheD	-	-	HJ	-	-	-	YheC/D like ATP-grasp
HMBIOMIE_01522	3.37e-276	yheC	-	-	HJ	-	-	-	YheC/D like ATP-grasp
HMBIOMIE_01523	1.51e-261	yheB	-	-	S	-	-	-	Belongs to the UPF0754 family
HMBIOMIE_01524	7.46e-72	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
HMBIOMIE_01525	6.69e-264	yhaZ	-	-	L	-	-	-	DNA alkylation repair enzyme
HMBIOMIE_01526	8.7e-198	yhaX	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HMBIOMIE_01527	0.0	hemZ	-	-	H	-	-	-	coproporphyrinogen III oxidase
HMBIOMIE_01528	1.85e-267	yhaU	-	-	P	ko:K03455	-	ko00000	COG0475 Kef-type K transport systems, membrane components
HMBIOMIE_01529	6.51e-114	-	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
HMBIOMIE_01531	1.6e-172	yhaR	-	-	I	-	-	-	enoyl-CoA hydratase
HMBIOMIE_01532	2.29e-36	-	-	-	S	-	-	-	YhzD-like protein
HMBIOMIE_01533	5.56e-215	yhaQ	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01534	5.14e-272	yhaP	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	COG1668 ABC-type Na efflux pump, permease component
HMBIOMIE_01535	9.85e-303	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	DNA repair exonuclease
HMBIOMIE_01536	0.0	yhaN	-	-	L	-	-	-	AAA domain
HMBIOMIE_01537	5.22e-228	yhaM	-	-	L	ko:K03698	-	ko00000,ko01000,ko03019	Shows a 3'-5' exoribonuclease activity
HMBIOMIE_01538	1.88e-39	yhaL	-	-	S	-	-	-	Sporulation protein YhaL
HMBIOMIE_01539	2.29e-179	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HMBIOMIE_01540	1.4e-116	yhaK	-	-	S	-	-	-	Putative zincin peptidase
HMBIOMIE_01541	8.48e-73	yhaI	-	-	S	-	-	-	Protein of unknown function (DUF1878)
HMBIOMIE_01542	4.92e-148	hpr	-	-	K	ko:K09682	-	ko00000,ko03000	Negative regulator of protease production and sporulation
HMBIOMIE_01543	1.74e-54	yhaH	-	-	S	-	-	-	YtxH-like protein
HMBIOMIE_01544	6.32e-104	trpP	-	-	S	-	-	-	Tryptophan transporter TrpP
HMBIOMIE_01545	1.84e-262	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMBIOMIE_01546	3.5e-106	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
HMBIOMIE_01547	2.7e-176	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	transporter (ATP-binding protein)
HMBIOMIE_01548	3.11e-272	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HMBIOMIE_01549	5e-162	ecsC	-	-	S	-	-	-	EcsC protein family
HMBIOMIE_01550	4.8e-295	yhaA	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
HMBIOMIE_01551	8.98e-317	yhfA	-	-	C	-	-	-	membrane
HMBIOMIE_01552	1.33e-23	-	-	-	C	-	-	-	Rubrerythrin
HMBIOMIE_01553	1.31e-118	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
HMBIOMIE_01554	0.0	pbpF	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HMBIOMIE_01555	7.78e-261	hemE	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMBIOMIE_01556	2.06e-232	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
HMBIOMIE_01557	0.0	hemY	1.3.3.15, 1.3.3.4	-	H	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HMBIOMIE_01558	3.49e-133	yhgD	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01559	0.0	yhgE	-	-	S	ko:K01421	-	ko00000	YhgE Pip N-terminal domain protein
HMBIOMIE_01560	7.21e-236	fabHB	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMBIOMIE_01561	1.61e-178	yhfC	-	-	S	-	-	-	Putative membrane peptidase family (DUF2324)
HMBIOMIE_01562	2.68e-253	yhfE	-	-	G	-	-	-	peptidase M42
HMBIOMIE_01563	3.75e-94	-	-	-	S	-	-	-	ASCH
HMBIOMIE_01564	4.77e-289	gltT	-	-	C	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
HMBIOMIE_01565	5.93e-183	yhfI	-	-	S	-	-	-	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
HMBIOMIE_01566	1.21e-246	lplJ	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
HMBIOMIE_01567	1.82e-144	yhfK	-	-	GM	-	-	-	NmrA-like family
HMBIOMIE_01568	0.0	yhfL	6.2.1.3	-	IQ	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
HMBIOMIE_01569	2.78e-85	yhfM	-	-	-	-	-	-	-
HMBIOMIE_01570	9.64e-308	yhfN	-	-	O	-	-	-	Peptidase M48
HMBIOMIE_01571	6.91e-260	aprE	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_01572	1.26e-101	-	-	-	K	-	-	-	acetyltransferase
HMBIOMIE_01573	5.66e-231	yhfP	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Quinone oxidoreductase
HMBIOMIE_01574	4.59e-222	yhfQ	-	-	M	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
HMBIOMIE_01575	9.64e-141	yhfR	5.4.2.12	-	G	ko:K15634,ko:K15640	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the phosphoglycerate mutase family
HMBIOMIE_01576	8.58e-250	yhfS	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HMBIOMIE_01577	0.0	vraA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
HMBIOMIE_01578	8.51e-118	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
HMBIOMIE_01579	1.85e-260	hemAT	-	-	NT	ko:K06595	-	ko00000,ko02035	chemotaxis protein
HMBIOMIE_01580	0.0	yhfW	-	-	CE	-	-	-	COG0665 Glycine D-amino acid oxidases (deaminating)
HMBIOMIE_01581	7.82e-204	yhxC	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_01582	9.84e-45	yhzC	-	-	S	-	-	-	IDEAL
HMBIOMIE_01583	2.19e-141	comK	-	-	K	ko:K02250	ko02024,map02024	ko00000,ko00001,ko02044,ko03000	Competence transcription factor
HMBIOMIE_01584	2.55e-216	yhxD	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_01585	5e-57	yhjA	-	-	S	-	-	-	Excalibur calcium-binding domain
HMBIOMIE_01586	0.0	yhjB	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMBIOMIE_01587	1.61e-36	yhjC	-	-	S	-	-	-	Protein of unknown function (DUF3311)
HMBIOMIE_01588	2.57e-78	yhjD	-	-	-	-	-	-	-
HMBIOMIE_01589	4.87e-141	yhjE	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_01590	3.09e-118	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HMBIOMIE_01591	0.0	yhjG	-	-	CH	-	-	-	FAD binding domain
HMBIOMIE_01592	2.82e-122	yhjH	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_01593	3.12e-273	glcP	-	-	G	ko:K08174	-	ko00000,ko02000	Major Facilitator Superfamily
HMBIOMIE_01594	3.98e-257	-	1.1.1.18, 1.1.1.361, 1.1.1.369	-	S	ko:K00010,ko:K18652	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
HMBIOMIE_01595	2.63e-205	ntdB	3.1.3.24, 3.1.3.92	-	S	ko:K07024,ko:K18654	ko00500,map00500	ko00000,ko00001,ko01000	Sucrose-6F-phosphate phosphohydrolase
HMBIOMIE_01596	0.0	-	2.6.1.104	-	E	ko:K18653	-	ko00000,ko01000	Belongs to the DegT DnrJ EryC1 family
HMBIOMIE_01597	2.52e-238	yhjM	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01598	2.5e-259	yhjN	-	-	S	ko:K07120	-	ko00000	membrane
HMBIOMIE_01599	1.27e-272	-	-	-	EGP	-	-	-	Transmembrane secretion effector
HMBIOMIE_01600	0.0	-	-	-	S	-	-	-	Sugar transport-related sRNA regulator N-term
HMBIOMIE_01601	3.54e-77	yhjQ	-	-	C	-	-	-	COG1145 Ferredoxin
HMBIOMIE_01602	9.3e-102	yhjR	-	-	S	-	-	-	Rubrerythrin
HMBIOMIE_01603	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	ATP-dependent helicase deoxyribonuclease subunit B
HMBIOMIE_01604	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
HMBIOMIE_01605	1.2e-281	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HMBIOMIE_01606	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	COG0419 ATPase involved in DNA repair
HMBIOMIE_01607	1.34e-66	yisB	-	-	V	-	-	-	COG1403 Restriction endonuclease
HMBIOMIE_01608	3.3e-43	gerPF	-	-	S	ko:K06299,ko:K06304	-	ko00000	Spore germination protein gerPA/gerPF
HMBIOMIE_01609	4.08e-88	gerPE	-	-	S	ko:K06303	-	ko00000	Spore germination protein GerPE
HMBIOMIE_01610	7.36e-34	gerPD	-	-	S	ko:K06302	-	ko00000	Spore germination protein
HMBIOMIE_01611	8.23e-93	gerPC	-	-	S	ko:K06301	-	ko00000	Spore germination protein
HMBIOMIE_01612	1.76e-47	gerPB	-	-	S	ko:K06300	-	ko00000	cell differentiation
HMBIOMIE_01613	1.82e-45	gerPA	-	-	S	ko:K06299	-	ko00000	Spore germination protein
HMBIOMIE_01614	1.52e-32	yisI	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
HMBIOMIE_01615	3.96e-224	cotH	-	-	M	ko:K06330	-	ko00000	Spore Coat
HMBIOMIE_01616	2.66e-219	yisK	-	-	Q	-	-	-	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
HMBIOMIE_01617	1.02e-74	yisL	-	-	S	-	-	-	UPF0344 protein
HMBIOMIE_01618	0.0	wprA	-	-	O	ko:K13274	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_01619	7.48e-137	yisN	-	-	S	-	-	-	Protein of unknown function (DUF2777)
HMBIOMIE_01620	0.0	asnO	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HMBIOMIE_01621	1.85e-115	yizA	-	-	S	-	-	-	Damage-inducible protein DinB
HMBIOMIE_01622	6.82e-193	crtM	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	phytoene
HMBIOMIE_01623	1.68e-309	yisQ	-	-	V	-	-	-	Mate efflux family protein
HMBIOMIE_01624	1.41e-207	yisR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01625	1.83e-235	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
HMBIOMIE_01626	9.72e-254	yisS	1.1.1.18, 1.1.1.369, 1.1.1.370	-	S	ko:K00010,ko:K16043	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
HMBIOMIE_01627	2.09e-121	yisT	-	-	S	-	-	-	DinB family
HMBIOMIE_01628	2.08e-128	argO	-	-	S	ko:K06895	-	ko00000,ko02000	Lysine exporter protein LysE YggA
HMBIOMIE_01629	0.0	ydfD	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_01630	2.15e-96	yisX	-	-	S	-	-	-	Pentapeptide repeats (9 copies)
HMBIOMIE_01631	2.25e-199	yisY	1.11.1.10	-	I	ko:K00433	-	ko00000,ko01000	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
HMBIOMIE_01632	4.06e-145	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
HMBIOMIE_01633	1.37e-295	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
HMBIOMIE_01634	9.51e-185	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
HMBIOMIE_01635	1.34e-162	-	3.1.3.71	-	H	ko:K05979	ko00680,ko01120,map00680,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the ComB family
HMBIOMIE_01636	4.31e-180	yitD	4.4.1.19	-	S	ko:K08097	ko00680,ko01120,map00680,map01120	ko00000,ko00001,ko00002,ko01000	synthase
HMBIOMIE_01637	6.77e-145	yitE	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMBIOMIE_01638	2.14e-283	yitF	5.5.1.27	-	M	ko:K18983	ko00053,map00053	ko00000,ko00001,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HMBIOMIE_01639	1.01e-291	yitG	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_01640	7.86e-207	yitH	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_01641	3.34e-106	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_01642	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
HMBIOMIE_01643	4.29e-77	yitK	-	-	S	ko:K09767	-	ko00000	Belongs to the UPF0234 family
HMBIOMIE_01644	1.94e-204	yitL	-	-	S	ko:K00243	-	ko00000	protein conserved in bacteria
HMBIOMIE_01645	4.16e-122	-	-	-	-	-	-	-	-
HMBIOMIE_01646	2.02e-218	-	-	-	-	-	-	-	-
HMBIOMIE_01647	3.29e-127	-	-	-	S	-	-	-	Sporulation delaying protein SdpA
HMBIOMIE_01648	2.08e-77	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
HMBIOMIE_01649	5.24e-121	-	-	-	-	-	-	-	-
HMBIOMIE_01650	4.59e-59	yitR	-	-	S	-	-	-	Domain of unknown function (DUF3784)
HMBIOMIE_01651	0.0	nprB	3.4.24.28	-	E	ko:K01400,ko:K08777	ko02024,map02024	ko00000,ko00001,ko01000,ko01002	Peptidase M4
HMBIOMIE_01652	9.13e-202	yitS	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01653	2.29e-189	yitT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
HMBIOMIE_01654	9.69e-94	ipi	-	-	S	-	-	-	Intracellular proteinase inhibitor
HMBIOMIE_01655	1.01e-25	-	-	-	S	-	-	-	Protein of unknown function (DUF3813)
HMBIOMIE_01656	1.92e-08	-	-	-	-	-	-	-	-
HMBIOMIE_01657	2.16e-198	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
HMBIOMIE_01658	8.38e-184	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
HMBIOMIE_01659	3.26e-68	yitW	-	-	S	-	-	-	metal-sulfur cluster biosynthetic enzyme
HMBIOMIE_01660	1.74e-31	-	-	-	S	-	-	-	Proteolipid membrane potential modulator
HMBIOMIE_01661	0.0	yitY	-	-	C	-	-	-	D-arabinono-1,4-lactone oxidase
HMBIOMIE_01662	3.24e-114	yitZ	-	-	G	-	-	-	Major Facilitator Superfamily
HMBIOMIE_01663	9.02e-256	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMBIOMIE_01664	7.4e-295	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMBIOMIE_01665	5.4e-177	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMBIOMIE_01666	1.69e-278	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
HMBIOMIE_01667	1.4e-263	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HMBIOMIE_01668	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
HMBIOMIE_01669	3.66e-226	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMBIOMIE_01670	2.51e-39	yjzC	-	-	S	-	-	-	YjzC-like protein
HMBIOMIE_01671	2.17e-23	yjzD	-	-	S	-	-	-	Protein of unknown function (DUF2929)
HMBIOMIE_01672	2.42e-182	yjaU	-	-	I	-	-	-	carboxylic ester hydrolase activity
HMBIOMIE_01673	5.41e-134	yjaV	-	-	-	-	-	-	-
HMBIOMIE_01674	6.4e-235	med	-	-	S	ko:K05519,ko:K07335	-	ko00000,ko03000	Transcriptional activator protein med
HMBIOMIE_01675	1.07e-35	comZ	-	-	S	ko:K02254	-	ko00000,ko02044	ComZ
HMBIOMIE_01676	2.67e-38	yjzB	-	-	-	-	-	-	-
HMBIOMIE_01677	1.61e-221	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMBIOMIE_01678	3.06e-302	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HMBIOMIE_01679	9.48e-193	yjaZ	-	-	O	-	-	-	Zn-dependent protease
HMBIOMIE_01680	6.15e-234	appD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01681	2.07e-237	appF	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01682	0.0	appA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
HMBIOMIE_01683	1.04e-219	appB	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01684	1.03e-208	appC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01685	3.18e-190	yjbA	-	-	S	-	-	-	Belongs to the UPF0736 family
HMBIOMIE_01686	6.15e-235	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
HMBIOMIE_01687	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HMBIOMIE_01688	1.03e-212	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01689	7.55e-212	oppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01690	1.37e-249	oppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01691	4.43e-220	oppF	-	-	E	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01692	3.98e-248	yjbB	-	-	EGP	-	-	-	Major Facilitator Superfamily
HMBIOMIE_01693	2.65e-133	yjbC	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_01694	1.01e-87	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HMBIOMIE_01695	7.1e-144	yjbE	-	-	P	-	-	-	Integral membrane protein TerC family
HMBIOMIE_01696	6.89e-151	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
HMBIOMIE_01697	1.31e-283	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
HMBIOMIE_01698	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
HMBIOMIE_01699	2.68e-28	-	-	-	-	-	-	-	-
HMBIOMIE_01701	1.32e-218	yjbH	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
HMBIOMIE_01702	8.58e-94	yjbI	-	-	S	ko:K06886	-	ko00000	Bacterial-like globin
HMBIOMIE_01703	3.42e-127	yjbJ	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HMBIOMIE_01704	5.15e-130	yjbK	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01705	1.87e-81	yjbL	-	-	S	-	-	-	Belongs to the UPF0738 family
HMBIOMIE_01706	5.06e-145	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	GTP pyrophosphokinase
HMBIOMIE_01707	2.94e-194	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMBIOMIE_01708	9.4e-206	rluD	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HMBIOMIE_01709	8.09e-181	prpE	3.1.3.16, 3.6.1.41	-	T	ko:K01090,ko:K01525	ko00230,map00230	ko00000,ko00001,ko01000	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
HMBIOMIE_01710	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HMBIOMIE_01711	5.7e-177	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMBIOMIE_01712	4.01e-139	tenI	5.3.99.10	-	H	ko:K10810	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Transcriptional regulator TenI
HMBIOMIE_01713	1.14e-277	thiO	1.4.3.19, 1.4.5.1	-	E	ko:K00285,ko:K03153	ko00360,ko00730,ko01100,map00360,map00730,map01100	ko00000,ko00001,ko01000	Glycine oxidase
HMBIOMIE_01714	5.35e-42	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	thiamine diphosphate biosynthetic process
HMBIOMIE_01715	6.78e-174	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
HMBIOMIE_01716	1.52e-238	thiF	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HMBIOMIE_01717	8.38e-192	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HMBIOMIE_01718	1.23e-182	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
HMBIOMIE_01719	2.32e-107	yjbX	-	-	S	-	-	-	Spore coat protein
HMBIOMIE_01720	4.57e-108	cotZ	-	-	S	ko:K06344	-	ko00000	Spore coat protein
HMBIOMIE_01721	3.12e-124	cotY	-	-	S	ko:K06343	-	ko00000	Spore coat protein Z
HMBIOMIE_01722	3.55e-110	cotX	-	-	S	ko:K06342	-	ko00000	Spore Coat Protein X and V domain
HMBIOMIE_01723	1.08e-54	cotW	-	-	-	ko:K06341	-	ko00000	-
HMBIOMIE_01724	1.44e-72	cotV	-	-	S	ko:K06340	-	ko00000	Spore Coat Protein X and V domain
HMBIOMIE_01725	3.03e-76	yjcA	-	-	S	-	-	-	Protein of unknown function (DUF1360)
HMBIOMIE_01728	1.88e-52	spoVIF	-	-	S	-	-	-	Stage VI sporulation protein F
HMBIOMIE_01729	0.0	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HMBIOMIE_01730	6.31e-51	-	-	-	-	-	-	-	-
HMBIOMIE_01731	7.75e-94	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_01732	1.2e-121	yjcG	-	-	J	-	-	-	Belongs to the 2H phosphoesterase superfamily. YjcG family
HMBIOMIE_01733	1.63e-178	yjcH	-	-	P	ko:K07214	-	ko00000	COG2382 Enterochelin esterase and related enzymes
HMBIOMIE_01734	1.98e-273	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HMBIOMIE_01735	6.4e-281	metC	4.4.1.8	-	E	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HMBIOMIE_01736	2.13e-129	yjcK	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Alanine acetyltransferase
HMBIOMIE_01737	2.58e-274	yjcL	-	-	S	-	-	-	Protein of unknown function (DUF819)
HMBIOMIE_01740	3.75e-269	-	-	-	S	-	-	-	Putative amidase domain
HMBIOMIE_01741	1.52e-68	yjcN	-	-	-	-	-	-	-
HMBIOMIE_01744	2.24e-106	-	-	-	L	-	-	-	Transposase
HMBIOMIE_01745	5.68e-100	yjcP	-	-	-	-	-	-	-
HMBIOMIE_01746	1.01e-65	-	-	-	S	-	-	-	YjcQ protein
HMBIOMIE_01747	3.29e-121	yqaS	-	-	L	-	-	-	DNA packaging
HMBIOMIE_01748	3.8e-63	yjcS	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
HMBIOMIE_01749	3.42e-181	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_01750	0.000759	-	-	-	-	-	-	-	-
HMBIOMIE_01751	0.0	manR	-	-	GKT	ko:K02538,ko:K03491	-	ko00000,ko03000	transcriptional antiterminator
HMBIOMIE_01752	0.0	manP	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_01753	2.95e-239	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HMBIOMIE_01754	4.79e-78	yjdF3	-	-	S	-	-	-	Protein of unknown function (DUF2992)
HMBIOMIE_01755	1.36e-121	-	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HMBIOMIE_01757	1.01e-105	ebsC	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMBIOMIE_01758	6.12e-40	-	-	-	S	-	-	-	Domain of unknown function (DUF4177)
HMBIOMIE_01759	2.31e-69	yjdJ	-	-	S	-	-	-	Domain of unknown function (DUF4306)
HMBIOMIE_01760	5.31e-224	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HMBIOMIE_01762	0.0	yjeA	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
HMBIOMIE_01763	2.22e-108	-	-	-	S	-	-	-	Protein of unknown function (DUF2690)
HMBIOMIE_01764	1.13e-29	yjfB	-	-	S	-	-	-	Putative motility protein
HMBIOMIE_01765	3.24e-219	yjfC	-	-	O	-	-	-	Predicted Zn-dependent protease (DUF2268)
HMBIOMIE_01766	1.38e-59	yjgA	-	-	T	-	-	-	Protein of unknown function (DUF2809)
HMBIOMIE_01767	1.22e-133	yjgB	-	-	S	-	-	-	Domain of unknown function (DUF4309)
HMBIOMIE_01768	0.0	yjgC	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase (NAD+) activity
HMBIOMIE_01769	1.6e-122	yjgD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
HMBIOMIE_01771	4.43e-149	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
HMBIOMIE_01773	1.52e-282	yjiB	1.14.14.46, 1.14.15.13	-	C	ko:K15468,ko:K16593,ko:K17474	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
HMBIOMIE_01774	8.74e-280	yjiC	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HMBIOMIE_01775	1.11e-41	-	-	-	-	-	-	-	-
HMBIOMIE_01776	2.78e-183	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
HMBIOMIE_01777	9.04e-156	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	transport system, permease component
HMBIOMIE_01778	3.81e-173	yjkB	-	-	P	ko:K02068	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HMBIOMIE_01779	1.81e-224	yjlA	-	-	EG	-	-	-	Putative multidrug resistance efflux transporter
HMBIOMIE_01780	2.99e-119	yjlB	-	-	S	-	-	-	Cupin domain
HMBIOMIE_01781	1.39e-87	yjlC	-	-	S	-	-	-	Protein of unknown function (DUF1641)
HMBIOMIE_01782	2.15e-280	yjlD	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HMBIOMIE_01783	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
HMBIOMIE_01784	4.34e-314	-	-	-	G	ko:K03292	-	ko00000	symporter YjmB
HMBIOMIE_01785	1.26e-242	allD	1.1.1.350	-	C	ko:K00073	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000	Belongs to the LDH2 MDH2 oxidoreductase family
HMBIOMIE_01786	1.6e-246	yjmD	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
HMBIOMIE_01787	1.66e-274	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
HMBIOMIE_01788	1.34e-196	yjmF	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_01789	1.37e-289	exuT	-	-	G	ko:K03535,ko:K08191	-	ko00000,ko02000	Sugar (and other) transporter
HMBIOMIE_01790	6.95e-238	exuR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
HMBIOMIE_01791	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
HMBIOMIE_01792	0.0	uxaA	4.2.1.42, 4.2.1.7	-	G	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
HMBIOMIE_01793	4.56e-167	yjnA	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HMBIOMIE_01794	2.71e-103	yjoA	-	-	S	-	-	-	DinB family
HMBIOMIE_01795	6.08e-314	VCP	-	-	O	-	-	-	AAA domain (dynein-related subfamily)
HMBIOMIE_01796	8.59e-272	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
HMBIOMIE_01798	1.79e-55	-	-	-	S	-	-	-	YCII-related domain
HMBIOMIE_01799	1.08e-217	xlyB	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
HMBIOMIE_01800	3.87e-80	yjqA	-	-	S	-	-	-	Bacterial PH domain
HMBIOMIE_01801	5.99e-143	yjqB	-	-	S	-	-	-	Pfam:DUF867
HMBIOMIE_01802	4.54e-204	yjqC	-	-	P	ko:K07217	-	ko00000	Catalase
HMBIOMIE_01803	2.44e-141	xkdA	-	-	E	-	-	-	IrrE N-terminal-like domain
HMBIOMIE_01804	2.01e-74	xre	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HMBIOMIE_01806	4.36e-202	xkdB	-	-	K	-	-	-	sequence-specific DNA binding
HMBIOMIE_01807	1.44e-150	xkdC	-	-	L	-	-	-	Bacterial dnaA protein
HMBIOMIE_01811	6.41e-107	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
HMBIOMIE_01812	1.95e-178	xtmA	-	-	L	ko:K07474	-	ko00000	phage terminase small subunit
HMBIOMIE_01813	0.0	xtmB	-	-	S	ko:K06909	-	ko00000	phage terminase, large subunit
HMBIOMIE_01814	0.0	yqbA	-	-	S	-	-	-	portal protein
HMBIOMIE_01815	1.99e-176	xkdF3	-	-	L	-	-	-	Putative phage serine protease XkdF
HMBIOMIE_01816	1.59e-216	xkdG	-	-	S	-	-	-	Phage capsid family
HMBIOMIE_01817	2.06e-85	yqbG	-	-	S	-	-	-	Protein of unknown function (DUF3199)
HMBIOMIE_01818	1.05e-85	yqbH	-	-	S	-	-	-	Domain of unknown function (DUF3599)
HMBIOMIE_01819	5.84e-115	xkdI	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
HMBIOMIE_01820	2.87e-101	xkdJ	-	-	-	-	-	-	-
HMBIOMIE_01821	0.0	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
HMBIOMIE_01822	6.01e-99	xkdM	-	-	S	-	-	-	Phage tail tube protein
HMBIOMIE_01823	3.34e-101	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
HMBIOMIE_01824	0.0	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
HMBIOMIE_01825	1.77e-158	xkdP	-	-	S	-	-	-	Lysin motif
HMBIOMIE_01826	2.31e-232	xkdQ	-	-	G	-	-	-	NLP P60 protein
HMBIOMIE_01827	4.32e-53	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
HMBIOMIE_01828	1.97e-92	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
HMBIOMIE_01829	7.59e-245	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMBIOMIE_01830	9.63e-136	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
HMBIOMIE_01831	4.43e-56	-	-	-	-	-	-	-	-
HMBIOMIE_01832	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_01833	8.68e-74	xkdW	-	-	S	-	-	-	XkdW protein
HMBIOMIE_01834	9.34e-33	xkdX	-	-	-	-	-	-	-
HMBIOMIE_01835	1.51e-198	xepA	-	-	-	-	-	-	-
HMBIOMIE_01836	7.71e-52	xhlA	-	-	S	-	-	-	Haemolysin XhlA
HMBIOMIE_01837	8.12e-53	xhlB	-	-	S	-	-	-	SPP1 phage holin
HMBIOMIE_01838	5.76e-212	xlyA	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	n-acetylmuramoyl-L-alanine amidase
HMBIOMIE_01839	1.78e-31	spoIISB	-	-	S	ko:K06389	-	ko00000	Stage II sporulation protein SB
HMBIOMIE_01840	1.19e-175	spoIISA	-	-	S	ko:K06388	-	ko00000	Toxin SpoIISA, type II toxin-antitoxin system
HMBIOMIE_01841	1.54e-225	pit	-	-	P	ko:K03306	-	ko00000	phosphate transporter
HMBIOMIE_01842	1.85e-144	ykaA	-	-	P	ko:K07220	-	ko00000	COG1392 Phosphate transport regulator (distant homolog of PhoU)
HMBIOMIE_01843	7.7e-311	steT	-	-	E	ko:K03294	-	ko00000	amino acid
HMBIOMIE_01844	3.43e-234	ykcA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
HMBIOMIE_01846	0.0	ykcB	-	-	M	-	-	-	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HMBIOMIE_01847	1.34e-230	ykcC	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
HMBIOMIE_01849	6.72e-288	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMBIOMIE_01850	1.54e-183	proG	1.5.1.2	-	E	ko:K00286,ko:K02239	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko02044	Pyrroline-5-carboxylate reductase
HMBIOMIE_01851	2.42e-197	dppA	-	-	E	ko:K16203	-	ko00000,ko01000,ko01002	D-aminopeptidase
HMBIOMIE_01852	9.7e-204	dppB	-	-	P	ko:K16200	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01853	6.35e-226	dppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMBIOMIE_01854	6.22e-242	dppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01855	0.0	dppE	-	-	E	ko:K16199	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HMBIOMIE_01857	1e-226	ykfA	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
HMBIOMIE_01858	1.62e-255	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HMBIOMIE_01859	3.08e-211	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HMBIOMIE_01860	8.44e-237	ykfD	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_01861	9.83e-262	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconolactonase
HMBIOMIE_01862	4.37e-206	ykgA	-	-	E	-	-	-	Amidinotransferase
HMBIOMIE_01863	3.82e-120	ykhA	-	-	I	-	-	-	Acyl-CoA hydrolase
HMBIOMIE_01864	2.65e-289	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HMBIOMIE_01865	5.85e-13	-	-	-	-	-	-	-	-
HMBIOMIE_01866	3.95e-167	ykjA	-	-	S	-	-	-	Protein of unknown function (DUF421)
HMBIOMIE_01867	1.57e-128	ykkA	-	-	S	-	-	-	Protein of unknown function (DUF664)
HMBIOMIE_01868	3.59e-128	ykkB	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
HMBIOMIE_01869	1.27e-72	ykkC	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Multidrug resistance protein
HMBIOMIE_01870	1.36e-66	ykkD	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Multidrug resistance protein
HMBIOMIE_01871	1.6e-215	purU	3.5.1.10	-	F	ko:K01433	ko00630,ko00670,map00630,map00670	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
HMBIOMIE_01872	3.68e-256	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMBIOMIE_01873	2.66e-288	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMBIOMIE_01875	2.39e-93	ohrA	-	-	O	-	-	-	Organic hydroperoxide resistance protein
HMBIOMIE_01876	1.66e-96	ohrR	-	-	K	-	-	-	COG1846 Transcriptional regulators
HMBIOMIE_01877	8.15e-94	ohrB	-	-	O	-	-	-	Organic hydroperoxide resistance protein
HMBIOMIE_01879	5.67e-115	guaD	3.5.4.3	-	FJ	ko:K01487	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	COG0590 Cytosine adenosine deaminases
HMBIOMIE_01880	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMBIOMIE_01881	6.07e-225	isp	-	-	O	ko:K13275	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_01882	3.99e-193	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMBIOMIE_01883	3.12e-174	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
HMBIOMIE_01884	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_01885	1.39e-127	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
HMBIOMIE_01886	2.34e-140	ykoF	-	-	S	-	-	-	YKOF-related Family
HMBIOMIE_01887	3.03e-159	ykoG	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_01888	8.98e-309	ykoH	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_01889	3.74e-143	ykoI	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HMBIOMIE_01890	1.3e-111	ykoJ	-	-	S	-	-	-	Peptidase propeptide and YPEB domain
HMBIOMIE_01891	1.45e-08	-	-	-	-	-	-	-	-
HMBIOMIE_01893	9.86e-300	mgtE	-	-	P	ko:K06213	-	ko00000,ko02000	Acts as a magnesium transporter
HMBIOMIE_01894	1.49e-70	tnrA	-	-	K	-	-	-	transcriptional
HMBIOMIE_01895	1.63e-25	-	-	-	-	-	-	-	-
HMBIOMIE_01896	3.04e-36	ykoL	-	-	-	-	-	-	-
HMBIOMIE_01897	9.83e-106	ykoM	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
HMBIOMIE_01898	1.19e-281	ugtP	2.4.1.315	GT28	M	ko:K03429	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
HMBIOMIE_01899	2.48e-129	ykoP	-	-	G	-	-	-	polysaccharide deacetylase
HMBIOMIE_01900	4.35e-198	ykoQ	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
HMBIOMIE_01901	0.0	ykoS	-	-	-	-	-	-	-
HMBIOMIE_01902	5.72e-239	ykoT	-	-	M	-	-	-	COG0463 Glycosyltransferases involved in cell wall biogenesis
HMBIOMIE_01903	0.0	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
HMBIOMIE_01904	7.55e-206	ku	-	-	L	ko:K10979	ko03450,map03450	ko00000,ko00001,ko03400	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HMBIOMIE_01905	0.0	ykoW	2.7.7.65	-	T	ko:K21023	ko02025,map02025	ko00000,ko00001,ko01000	Diguanylate cyclase
HMBIOMIE_01906	4.48e-153	ykoX	-	-	S	-	-	-	membrane-associated protein
HMBIOMIE_01907	4.63e-227	ykoY	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
HMBIOMIE_01908	1.8e-167	sigI	-	-	K	ko:K03093	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_01909	9.33e-219	rsgI	-	-	S	-	-	-	Anti-sigma factor N-terminus
HMBIOMIE_01910	1.4e-36	sspD	-	-	S	ko:K06421	-	ko00000	small acid-soluble spore protein
HMBIOMIE_01911	7.68e-160	ykrK	-	-	S	-	-	-	Domain of unknown function (DUF1836)
HMBIOMIE_01912	3.4e-200	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
HMBIOMIE_01913	1.82e-310	ktrD	-	-	P	-	-	-	COG0168 Trk-type K transport systems, membrane components
HMBIOMIE_01915	8.33e-31	ykzE	-	-	-	-	-	-	-
HMBIOMIE_01916	3.34e-244	ykrP	-	-	G	-	-	-	COG3594 Fucose 4-O-acetylase and related acetyltransferases
HMBIOMIE_01917	0.0	kinE	2.7.13.3	-	T	ko:K13533	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_01918	2.76e-115	ogt	2.1.1.63	-	L	ko:K00567,ko:K13531	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMBIOMIE_01920	1.62e-253	mtnA	5.3.1.23	-	E	ko:K08963	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HMBIOMIE_01921	2.47e-293	mtnK	2.7.1.100	-	F	ko:K00899	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HMBIOMIE_01922	1.99e-193	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
HMBIOMIE_01923	4.81e-296	mtnE	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HMBIOMIE_01924	3.39e-295	mtnW	5.3.2.5	-	G	ko:K08965	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
HMBIOMIE_01925	1.07e-176	mtnX	3.1.3.87	-	E	ko:K08966	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HMBIOMIE_01926	4.52e-147	mtnB	4.2.1.109	-	E	ko:K08964	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
HMBIOMIE_01927	1.5e-123	mtnD	1.13.11.53, 1.13.11.54	-	S	ko:K08967	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HMBIOMIE_01928	8.82e-68	-	-	-	S	-	-	-	Protein of unknown function (DUF1232)
HMBIOMIE_01930	5.84e-95	eag	-	-	-	-	-	-	-
HMBIOMIE_01931	0.0	kinD	2.7.13.3	-	T	ko:K13532	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
HMBIOMIE_01932	5.17e-99	ykvE	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
HMBIOMIE_01933	4.91e-170	motB	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
HMBIOMIE_01934	3.23e-178	motA	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
HMBIOMIE_01935	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
HMBIOMIE_01936	4.26e-230	ykvI	-	-	S	-	-	-	membrane
HMBIOMIE_01937	1.11e-161	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HMBIOMIE_01938	6.96e-105	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
HMBIOMIE_01939	3.56e-179	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
HMBIOMIE_01940	2.36e-125	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMBIOMIE_01941	2.8e-81	ykvN	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01942	9.35e-173	ykvO	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_01943	2.69e-275	-	-	-	M	-	-	-	Glycosyl transferases group 1
HMBIOMIE_01944	1.85e-48	-	3.5.1.104	-	M	ko:K22278	-	ko00000,ko01000	LysM domain
HMBIOMIE_01945	2.5e-169	-	-	-	G	-	-	-	Glycosyl hydrolases family 18
HMBIOMIE_01946	2.67e-62	ykvR	-	-	S	-	-	-	Protein of unknown function (DUF3219)
HMBIOMIE_01947	5.43e-35	ykvS	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01948	2.6e-39	-	-	-	-	-	-	-	-
HMBIOMIE_01949	9.09e-142	ykvT	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell Wall Hydrolase
HMBIOMIE_01950	1.12e-302	ykvU	-	-	S	-	-	-	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_01951	5.79e-117	stoA	-	-	CO	-	-	-	thiol-disulfide
HMBIOMIE_01952	0.0	zosA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
HMBIOMIE_01953	3.99e-09	-	-	-	-	-	-	-	-
HMBIOMIE_01954	7.85e-266	ykvY	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
HMBIOMIE_01956	3.28e-230	ykvZ	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01958	3.41e-168	glcT	-	-	K	ko:K03480,ko:K03488	-	ko00000,ko03000	antiterminator
HMBIOMIE_01959	0.0	ptsG	2.7.1.199	-	G	ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_01960	1.51e-53	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPr
HMBIOMIE_01961	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMBIOMIE_01962	1.54e-51	splA	-	-	S	ko:K06315	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_01963	2.13e-257	splB	4.1.99.14	-	L	ko:K03716	-	ko00000,ko01000	Spore photoproduct lyase
HMBIOMIE_01964	5.49e-170	ykwB	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_01965	0.0	mcpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_01966	1.4e-203	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
HMBIOMIE_01967	5.36e-172	ykwD	-	-	J	-	-	-	protein with SCP PR1 domains
HMBIOMIE_01968	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HMBIOMIE_01969	0.0	kinA	2.7.13.3	-	T	ko:K02491	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_01970	5.32e-286	patA	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HMBIOMIE_01971	1.05e-22	-	-	-	-	-	-	-	-
HMBIOMIE_01972	4.24e-217	cheV	-	-	T	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	Chemotaxis protein CheV
HMBIOMIE_01973	3.71e-110	ykyB	-	-	S	-	-	-	YkyB-like protein
HMBIOMIE_01974	8.89e-306	ykuC	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_01975	7.1e-116	ykuD	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01976	3.48e-212	ykuE	-	-	S	ko:K07098	-	ko00000	Metallophosphoesterase
HMBIOMIE_01977	1.83e-182	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_01978	9e-45	ybfG	-	-	M	-	-	-	Putative peptidoglycan binding domain
HMBIOMIE_01979	0.0	ybfG	-	-	M	-	-	-	Putative peptidoglycan binding domain
HMBIOMIE_01980	1.52e-120	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
HMBIOMIE_01982	1.76e-298	ykuI	-	-	T	-	-	-	Diguanylate phosphodiesterase
HMBIOMIE_01983	5.16e-50	ykuJ	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_01984	6.44e-122	-	-	-	S	ko:K09776	-	ko00000	Ribonuclease H-like
HMBIOMIE_01985	7.83e-38	ykzF	-	-	S	-	-	-	Antirepressor AbbA
HMBIOMIE_01986	5.15e-100	ykuL	-	-	S	-	-	-	CBS domain
HMBIOMIE_01987	6.52e-216	ccpC	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_01988	7.72e-114	-	-	-	C	ko:K03839	-	ko00000	Flavodoxin domain
HMBIOMIE_01989	1.33e-226	ykuO	-	-	-	-	-	-	-
HMBIOMIE_01990	1.3e-104	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HMBIOMIE_01991	1.31e-125	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HMBIOMIE_01992	7.99e-276	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HMBIOMIE_01993	7.23e-51	ykuS	-	-	S	-	-	-	Belongs to the UPF0180 family
HMBIOMIE_01994	4.1e-181	ykuT	-	-	M	ko:K22044	-	ko00000,ko02000	Mechanosensitive ion channel
HMBIOMIE_01995	9.78e-130	ykuU	-	-	O	-	-	-	Alkyl hydroperoxide reductase
HMBIOMIE_01996	6.25e-106	ykuV	-	-	CO	-	-	-	thiol-disulfide
HMBIOMIE_01997	4.71e-122	rok	-	-	K	-	-	-	Repressor of ComK
HMBIOMIE_01998	1.47e-201	yknT	-	-	-	ko:K06437	-	ko00000	-
HMBIOMIE_01999	9.21e-142	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
HMBIOMIE_02000	6.5e-246	moeB	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
HMBIOMIE_02001	1.05e-313	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	molybdopterin
HMBIOMIE_02002	3.44e-122	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
HMBIOMIE_02003	6.61e-110	moaE	2.8.1.12	-	H	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	COG0314 Molybdopterin converting factor, large subunit
HMBIOMIE_02004	6.92e-45	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HMBIOMIE_02005	0.0	yknU	-	-	V	ko:K06147,ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
HMBIOMIE_02006	0.0	yknV	-	-	V	ko:K02021,ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
HMBIOMIE_02007	1.6e-151	yknW	-	-	S	-	-	-	Yip1 domain
HMBIOMIE_02008	4.93e-235	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMBIOMIE_02009	6.1e-160	yknY	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_02010	2.1e-269	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
HMBIOMIE_02011	1.49e-175	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_02012	9.99e-216	pfkB	2.7.1.56	-	G	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
HMBIOMIE_02013	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HMBIOMIE_02014	1.72e-134	sipT	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HMBIOMIE_02015	5.43e-52	ykoA	-	-	-	-	-	-	-
HMBIOMIE_02016	0.0	ykpA	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMBIOMIE_02017	2.99e-217	panE1	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMBIOMIE_02018	2.07e-303	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
HMBIOMIE_02019	1.09e-18	-	-	-	S	-	-	-	Uncharacterized protein YkpC
HMBIOMIE_02020	6.17e-234	mreBH	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod-share determining protein MreBH
HMBIOMIE_02021	2.63e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	of stationary sporulation gene expression
HMBIOMIE_02022	4.59e-307	kinC	2.7.13.3	-	T	ko:K07698	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
HMBIOMIE_02023	9.21e-208	ykqA	-	-	P	-	-	-	Gamma-glutamyl cyclotransferase, AIG2-like
HMBIOMIE_02024	1.68e-148	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
HMBIOMIE_02025	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HMBIOMIE_02026	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMBIOMIE_02027	8.98e-42	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
HMBIOMIE_02028	2.03e-187	ykrA	-	-	S	-	-	-	hydrolases of the HAD superfamily
HMBIOMIE_02029	3.96e-131	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HMBIOMIE_02030	2.24e-19	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
HMBIOMIE_02031	6.82e-149	ykyA	-	-	L	-	-	-	Putative cell-wall binding lipoprotein
HMBIOMIE_02032	1.06e-258	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMBIOMIE_02033	1.75e-227	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMBIOMIE_02034	1.47e-301	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMBIOMIE_02035	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMBIOMIE_02036	4.55e-83	slp	-	-	CO	-	-	-	COG0526, thiol-disulfide isomerase and thioredoxins
HMBIOMIE_02037	0.0	speA	4.1.1.17, 4.1.1.19	-	E	ko:K01581,ko:K01585	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Arginine
HMBIOMIE_02038	1.34e-56	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
HMBIOMIE_02039	1.3e-152	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
HMBIOMIE_02040	4.48e-35	ykzI	-	-	-	-	-	-	-
HMBIOMIE_02041	9.48e-195	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase
HMBIOMIE_02042	1.48e-100	ykzC	-	-	S	-	-	-	Acetyltransferase (GNAT) family
HMBIOMIE_02043	1.28e-223	-	-	-	Q	-	-	-	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMBIOMIE_02044	0.0	mpl	3.4.24.28, 3.4.24.29	-	E	ko:K01400,ko:K01401,ko:K19351	ko01503,ko05150,map01503,map05150	ko00000,ko00001,ko01000,ko01002	Peptidase M4
HMBIOMIE_02045	0.0	ylaA	-	-	-	-	-	-	-
HMBIOMIE_02046	1.44e-56	ylaB	-	-	-	-	-	-	-
HMBIOMIE_02047	4.51e-118	ylaC	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_02049	1.74e-57	ylaE	-	-	-	-	-	-	-
HMBIOMIE_02050	2.21e-30	-	-	-	S	-	-	-	Family of unknown function (DUF5325)
HMBIOMIE_02051	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
HMBIOMIE_02052	4.4e-63	ylaH	-	-	S	-	-	-	YlaH-like protein
HMBIOMIE_02053	8.92e-44	ylaI	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02054	2.97e-127	ylaJ	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMBIOMIE_02055	3.76e-316	ylaK	-	-	T	ko:K07175	-	ko00000	ATPase related to phosphate starvation-inducible protein PhoH
HMBIOMIE_02056	9.32e-112	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HMBIOMIE_02057	4.25e-220	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
HMBIOMIE_02058	6.94e-59	ylaN	-	-	S	-	-	-	Belongs to the UPF0358 family
HMBIOMIE_02059	2.57e-273	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HMBIOMIE_02060	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HMBIOMIE_02061	2.97e-214	ctaA	-	-	O	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	ko00000,ko00001,ko00002,ko03029	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
HMBIOMIE_02062	1.7e-208	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
HMBIOMIE_02063	5.85e-253	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
HMBIOMIE_02064	0.0	ctaD	1.9.3.1	-	C	ko:K02274	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMBIOMIE_02065	1.84e-145	ctaE	1.9.3.1	-	C	ko:K02276	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
HMBIOMIE_02066	6.09e-70	ctaF	1.9.3.1	-	C	ko:K02277	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
HMBIOMIE_02067	1.04e-214	ctaG	-	-	S	ko:K02862	-	ko00000	cytochrome c oxidase
HMBIOMIE_02068	1.61e-81	ylbA	-	-	S	-	-	-	YugN-like family
HMBIOMIE_02069	1.08e-97	ylbB	-	-	T	-	-	-	COG0517 FOG CBS domain
HMBIOMIE_02070	4.58e-258	ylbC	-	-	S	-	-	-	protein with SCP PR1 domains
HMBIOMIE_02071	3.24e-89	ylbD	-	-	S	-	-	-	Putative coat protein
HMBIOMIE_02072	1.73e-48	ylbE	-	-	S	-	-	-	YlbE-like protein
HMBIOMIE_02073	2.34e-97	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
HMBIOMIE_02074	4.36e-52	ylbG	-	-	S	-	-	-	UPF0298 protein
HMBIOMIE_02075	2.12e-126	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
HMBIOMIE_02076	3.8e-111	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMBIOMIE_02077	2.73e-282	ylbJ	-	-	S	-	-	-	Sporulation integral membrane protein YlbJ
HMBIOMIE_02078	2.56e-176	ylbK	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
HMBIOMIE_02079	7.81e-239	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
HMBIOMIE_02080	5.94e-301	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
HMBIOMIE_02082	1.7e-117	ylbN	-	-	S	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
HMBIOMIE_02083	1.71e-37	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
HMBIOMIE_02084	5.75e-108	ylbO	-	-	S	ko:K06314	-	ko00000,ko03000	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
HMBIOMIE_02085	3.26e-116	ylbP	-	-	K	-	-	-	n-acetyltransferase
HMBIOMIE_02086	1.66e-216	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMBIOMIE_02087	0.0	bshC	-	-	S	ko:K22136	-	ko00000	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HMBIOMIE_02088	9.82e-102	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
HMBIOMIE_02089	4.97e-220	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HMBIOMIE_02090	3.42e-68	ftsL	-	-	D	-	-	-	Essential cell division protein
HMBIOMIE_02091	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HMBIOMIE_02092	0.0	spoVD	-	-	M	ko:K08384	ko00550,map00550	ko00000,ko00001,ko01011	stage V sporulation protein D
HMBIOMIE_02093	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMBIOMIE_02094	9.59e-220	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMBIOMIE_02095	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMBIOMIE_02096	6.64e-237	spoVE	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HMBIOMIE_02097	9.42e-258	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMBIOMIE_02098	1.3e-211	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
HMBIOMIE_02099	1.18e-178	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HMBIOMIE_02100	3.45e-146	ylxW	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02101	8.67e-132	ylxX	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02102	5.37e-76	sbp	-	-	S	-	-	-	small basic protein
HMBIOMIE_02103	4.88e-299	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HMBIOMIE_02104	1.84e-260	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMBIOMIE_02105	0.0	bpr	-	-	O	ko:K13276	-	ko00000,ko01000,ko01002,ko03110	COG1404 Subtilisin-like serine proteases
HMBIOMIE_02106	1.06e-220	spoIIGA	-	-	M	ko:K06383	-	ko00000,ko01000,ko01002	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
HMBIOMIE_02107	1.48e-160	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_02108	7.99e-180	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_02109	3.84e-189	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
HMBIOMIE_02110	0.0	argE	-	-	E	ko:K20895	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Acetylornithine deacetylase
HMBIOMIE_02111	3.58e-51	ylmC	-	-	S	-	-	-	sporulation protein
HMBIOMIE_02112	4.54e-204	ylmD	-	-	S	ko:K05810	-	ko00000,ko01000	Belongs to the multicopper oxidase YfiH RL5 family
HMBIOMIE_02113	1.05e-160	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMBIOMIE_02114	5.44e-88	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HMBIOMIE_02115	1.22e-53	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	membrane
HMBIOMIE_02116	1.49e-178	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
HMBIOMIE_02117	6.44e-100	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
HMBIOMIE_02118	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMBIOMIE_02119	1.58e-83	ylyA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
HMBIOMIE_02120	2.71e-103	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMBIOMIE_02121	2.9e-224	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HMBIOMIE_02122	4.45e-122	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMBIOMIE_02123	4.33e-293	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Xanthine uracil
HMBIOMIE_02124	7.29e-214	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
HMBIOMIE_02125	0.0	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HMBIOMIE_02126	1.31e-269	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HMBIOMIE_02127	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarB family
HMBIOMIE_02128	3.84e-185	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
HMBIOMIE_02129	1.33e-224	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HMBIOMIE_02130	6.56e-164	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HMBIOMIE_02131	3.8e-150	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMBIOMIE_02133	3.58e-183	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
HMBIOMIE_02134	7.32e-230	cysP	-	-	P	ko:K16331	-	ko00000,ko02000	phosphate transporter
HMBIOMIE_02135	2.62e-285	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
HMBIOMIE_02136	5.56e-142	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
HMBIOMIE_02137	1.24e-186	cobA	2.1.1.107	-	H	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
HMBIOMIE_02138	4.33e-189	sirB	4.99.1.4	-	S	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sirohydrochlorin ferrochelatase
HMBIOMIE_02139	2.28e-108	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
HMBIOMIE_02140	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
HMBIOMIE_02141	0.0	yloB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
HMBIOMIE_02142	8.41e-202	yloC	-	-	S	-	-	-	stress-induced protein
HMBIOMIE_02143	3.97e-54	ylzA	-	-	S	ko:K09777	-	ko00000	Belongs to the UPF0296 family
HMBIOMIE_02144	5.73e-143	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
HMBIOMIE_02145	6.21e-39	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HMBIOMIE_02146	4.59e-289	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMBIOMIE_02147	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMBIOMIE_02148	2.89e-110	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HMBIOMIE_02149	2.21e-226	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMBIOMIE_02150	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMBIOMIE_02151	3.73e-264	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HMBIOMIE_02152	3.03e-181	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
HMBIOMIE_02153	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HMBIOMIE_02154	1.37e-215	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HMBIOMIE_02155	4.68e-153	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HMBIOMIE_02156	2.83e-157	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
HMBIOMIE_02157	7.06e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
HMBIOMIE_02158	3.65e-78	yloU	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02159	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
HMBIOMIE_02160	2.05e-153	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
HMBIOMIE_02161	1.19e-201	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
HMBIOMIE_02162	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMBIOMIE_02163	6.22e-121	fapR	-	-	K	-	-	-	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
HMBIOMIE_02164	8.33e-230	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HMBIOMIE_02165	1.31e-218	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
HMBIOMIE_02166	3.5e-167	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
HMBIOMIE_02167	1.15e-43	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMBIOMIE_02168	2.12e-174	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HMBIOMIE_02169	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
HMBIOMIE_02170	3.38e-227	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HMBIOMIE_02171	1.67e-114	-	-	-	-	-	-	-	-
HMBIOMIE_02172	5.64e-66	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HMBIOMIE_02173	9.7e-309	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMBIOMIE_02174	1.13e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
HMBIOMIE_02175	2.95e-50	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
HMBIOMIE_02176	5.89e-81	ylqD	-	-	S	-	-	-	YlqD protein
HMBIOMIE_02177	1.84e-122	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMBIOMIE_02178	2.41e-177	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
HMBIOMIE_02179	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HMBIOMIE_02180	1.2e-201	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMBIOMIE_02181	2.04e-175	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMBIOMIE_02182	0.0	ylqG	-	-	-	-	-	-	-
HMBIOMIE_02183	1.7e-59	ylqH	-	-	S	ko:K04061	-	ko00000,ko02044	homolog of the cytoplasmic domain of flagellar protein FhlB
HMBIOMIE_02184	6.77e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
HMBIOMIE_02185	1.53e-213	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HMBIOMIE_02186	6.53e-218	dprA	-	-	LU	ko:K04096	-	ko00000	Rossmann fold nucleotide-binding protein involved in DNA uptake
HMBIOMIE_02187	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMBIOMIE_02188	5.45e-314	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HMBIOMIE_02189	1.13e-217	xerC	-	-	L	ko:K03733,ko:K04763	-	ko00000,ko03036	tyrosine recombinase XerC
HMBIOMIE_02190	3.01e-120	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HMBIOMIE_02191	0.0	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HMBIOMIE_02192	1.95e-175	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HMBIOMIE_02193	1.62e-83	flgB	-	-	N	ko:K02387	ko02040,map02040	ko00000,ko00001,ko02035	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
HMBIOMIE_02194	7.54e-99	flgC	-	-	N	ko:K02388	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the flagella basal body rod proteins family
HMBIOMIE_02195	5.5e-53	fliE	-	-	N	ko:K02408	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-basal body
HMBIOMIE_02196	0.0	fliF	-	-	N	ko:K02409	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	The M ring may be actively involved in energy transduction
HMBIOMIE_02197	6.08e-230	fliG	-	-	N	ko:K02410	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HMBIOMIE_02198	1.92e-144	fliH	-	-	NU	ko:K02411	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	COG1317 Flagellar biosynthesis type III secretory pathway protein
HMBIOMIE_02199	2.11e-308	fliI	3.6.3.14	-	NU	ko:K02412	ko02040,map02040	ko00000,ko00001,ko01000,ko02035,ko02044	COG1157 Flagellar biosynthesis type III secretory pathway ATPase
HMBIOMIE_02200	1.79e-91	fliJ	-	-	N	ko:K02413	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar biosynthesis chaperone
HMBIOMIE_02201	5.08e-84	ylxF	-	-	S	-	-	-	MgtE intracellular N domain
HMBIOMIE_02202	2.31e-314	fliK	-	-	N	ko:K02414	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-length control protein
HMBIOMIE_02203	2.81e-96	flgD	-	-	N	ko:K02389	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod modification protein
HMBIOMIE_02204	1.09e-179	flgG	-	-	N	ko:K02390	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod
HMBIOMIE_02205	5.59e-78	fliL	-	-	N	ko:K02415	-	ko00000,ko02035	Controls the rotational direction of flagella during chemotaxis
HMBIOMIE_02206	6.61e-231	fliM	-	-	N	ko:K02416	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
HMBIOMIE_02207	1.38e-253	fliY	-	-	N	ko:K02417	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035,ko02044	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HMBIOMIE_02208	2.12e-77	cheY	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	response regulator
HMBIOMIE_02209	5.54e-137	fliZ	-	-	N	ko:K02418	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthesis protein, FliO
HMBIOMIE_02210	1.21e-141	fliP	-	-	N	ko:K02419	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Plays a role in the flagellum-specific transport system
HMBIOMIE_02211	5.23e-50	fliQ	-	-	N	ko:K02420	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Role in flagellar biosynthesis
HMBIOMIE_02212	1.47e-170	fliR	-	-	N	ko:K02421	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthetic protein FliR
HMBIOMIE_02213	2.74e-244	flhB	-	-	N	ko:K02401	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HMBIOMIE_02214	0.0	flhA	-	-	N	ko:K02400	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HMBIOMIE_02215	5.65e-256	flhF	-	-	N	ko:K02404	-	ko00000,ko02035	Flagellar biosynthesis regulator FlhF
HMBIOMIE_02216	1.09e-200	ylxH	-	-	D	ko:K04562	-	ko00000,ko02035	Belongs to the ParA family
HMBIOMIE_02217	1.81e-252	cheB	3.1.1.61, 3.5.1.44	-	NT	ko:K03412	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
HMBIOMIE_02218	0.0	cheA	2.7.13.3	-	NT	ko:K03407	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	COG0643 Chemotaxis protein histidine kinase and related kinases
HMBIOMIE_02219	1.56e-103	cheW	-	-	NT	ko:K03408	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	COG0835 Chemotaxis signal transduction protein
HMBIOMIE_02220	5.06e-144	cheC	-	-	NT	ko:K03410	ko02030,map02030	ko00000,ko00001,ko02035	COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
HMBIOMIE_02221	3.34e-112	cheD	3.5.1.44	-	NT	ko:K03411	ko02030,map02030	ko00000,ko00001,ko01000,ko02035	Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
HMBIOMIE_02222	6.57e-176	sigD	-	-	K	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMBIOMIE_02223	6.91e-101	ylxL	-	-	-	-	-	-	-
HMBIOMIE_02224	1.49e-168	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
HMBIOMIE_02225	9.82e-202	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMBIOMIE_02226	5.82e-163	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
HMBIOMIE_02227	9.6e-119	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HMBIOMIE_02228	3.84e-187	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMBIOMIE_02229	5.77e-179	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
HMBIOMIE_02230	1.39e-276	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
HMBIOMIE_02231	6.84e-294	rasP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
HMBIOMIE_02232	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HMBIOMIE_02233	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMBIOMIE_02234	1.34e-104	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
HMBIOMIE_02235	5.49e-261	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
HMBIOMIE_02236	2.01e-57	ylxR	-	-	K	ko:K07742	-	ko00000	nucleic-acid-binding protein implicated in transcription termination
HMBIOMIE_02237	6.16e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
HMBIOMIE_02238	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMBIOMIE_02239	7.83e-60	ylxP	-	-	S	ko:K09764	-	ko00000	protein conserved in bacteria
HMBIOMIE_02240	3.29e-75	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMBIOMIE_02241	5.18e-221	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMBIOMIE_02242	1.63e-232	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
HMBIOMIE_02243	7.11e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMBIOMIE_02244	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
HMBIOMIE_02245	1.29e-235	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
HMBIOMIE_02246	1.62e-295	mlpA	-	-	S	-	-	-	Belongs to the peptidase M16 family
HMBIOMIE_02247	1.53e-56	ymxH	-	-	S	-	-	-	YlmC YmxH family
HMBIOMIE_02248	5.3e-208	dpaA	-	-	CH	ko:K06410	-	ko00000	Dipicolinate synthase subunit A
HMBIOMIE_02249	9.94e-142	spoVFB	-	-	H	ko:K06411	-	ko00000	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
HMBIOMIE_02250	1.66e-247	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMBIOMIE_02251	1.2e-283	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HMBIOMIE_02252	1.57e-201	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMBIOMIE_02253	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMBIOMIE_02254	5.01e-171	tepA	-	-	OU	-	-	-	COG0740 Protease subunit of ATP-dependent Clp proteases
HMBIOMIE_02255	4.94e-44	-	-	-	S	-	-	-	YlzJ-like protein
HMBIOMIE_02256	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HMBIOMIE_02257	1.28e-171	ymfC	-	-	K	ko:K03710	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_02258	2.08e-267	ymfD	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_02259	3.45e-301	albE	-	-	S	-	-	-	Peptidase M16
HMBIOMIE_02260	2.37e-309	ymfH	-	-	S	-	-	-	zinc protease
HMBIOMIE_02261	6.33e-168	ymfI	1.1.1.100	-	S	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
HMBIOMIE_02262	5.13e-55	ymfJ	-	-	S	-	-	-	Protein of unknown function (DUF3243)
HMBIOMIE_02263	3.91e-183	ymfK	-	-	S	-	-	-	Protein of unknown function (DUF3388)
HMBIOMIE_02264	3.05e-177	ymfM	-	-	S	ko:K15539	-	ko00000	protein conserved in bacteria
HMBIOMIE_02265	1.36e-131	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMBIOMIE_02266	3.71e-300	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
HMBIOMIE_02267	4.7e-239	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMBIOMIE_02268	8.43e-282	pbpX	-	-	V	-	-	-	Beta-lactamase
HMBIOMIE_02269	4.25e-306	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
HMBIOMIE_02270	6.18e-195	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
HMBIOMIE_02271	2.44e-49	spoVS	-	-	S	ko:K06416	-	ko00000	Stage V sporulation protein S
HMBIOMIE_02272	3.02e-255	tdh	1.1.1.103	-	C	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
HMBIOMIE_02273	1.02e-278	kbl	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
HMBIOMIE_02274	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMBIOMIE_02275	1.27e-89	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
HMBIOMIE_02276	1.74e-119	cotE	-	-	S	ko:K06328	-	ko00000	Spore coat protein
HMBIOMIE_02277	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMBIOMIE_02278	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMBIOMIE_02279	7.19e-93	-	-	-	S	-	-	-	Regulatory protein YrvL
HMBIOMIE_02281	1.38e-127	ymcC	-	-	S	-	-	-	Membrane
HMBIOMIE_02282	2.94e-141	pksA	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02283	4.02e-167	pksB	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	Polyketide biosynthesis
HMBIOMIE_02284	1.31e-208	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
HMBIOMIE_02285	2.08e-239	pksD	-	-	Q	ko:K15328	-	ko00000,ko01008	Acyl transferase domain
HMBIOMIE_02286	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
HMBIOMIE_02287	5.46e-51	acpK	-	-	IQ	ko:K15337	-	ko00000,ko01008	Phosphopantetheine attachment site
HMBIOMIE_02288	5.31e-304	-	2.3.1.179	-	I	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HMBIOMIE_02289	9.7e-314	pksG	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
HMBIOMIE_02290	2.48e-184	-	-	-	I	ko:K15312	-	ko00000,ko01008	enoyl-CoA hydratase
HMBIOMIE_02291	2.69e-177	pksI	-	-	I	ko:K15313	-	ko00000,ko01008	Belongs to the enoyl-CoA hydratase isomerase family
HMBIOMIE_02292	0.0	-	-	-	IQ	ko:K13611,ko:K13613,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
HMBIOMIE_02293	0.0	-	-	-	Q	ko:K13612	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
HMBIOMIE_02294	0.0	-	-	-	IQ	ko:K13611,ko:K13613,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
HMBIOMIE_02295	0.0	-	-	-	IQ	ko:K13611,ko:K13613,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
HMBIOMIE_02296	0.0	-	-	-	HQ	ko:K13615	-	ko00000,ko01004,ko01008	Beta-ketoacyl synthase
HMBIOMIE_02297	2.49e-297	cypA	1.14.14.46, 1.14.15.13	-	C	ko:K15468,ko:K16593,ko:K17474	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
HMBIOMIE_02298	2.8e-81	ymzB	-	-	-	-	-	-	-
HMBIOMIE_02299	4.8e-210	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
HMBIOMIE_02300	0.0	aprX	-	-	O	ko:K17734	-	ko00000,ko01000,ko01002	Belongs to the peptidase S8 family
HMBIOMIE_02301	3.96e-163	ymaC	-	-	S	-	-	-	Replication protein
HMBIOMIE_02302	1.03e-105	ymaD	-	-	O	-	-	-	redox protein, regulator of disulfide bond formation
HMBIOMIE_02303	1.57e-73	ebrB	-	-	P	ko:K03297,ko:K11814,ko:K11815	-	ko00000,ko00002,ko02000	COG2076 Membrane transporters of cations and cationic drugs
HMBIOMIE_02304	1.21e-67	ebrA	-	-	P	ko:K11814	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
HMBIOMIE_02306	5.41e-76	ymaF	-	-	S	-	-	-	YmaF family
HMBIOMIE_02307	9.69e-224	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMBIOMIE_02308	1.28e-45	hfq	-	-	J	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	ko00000,ko00001,ko03019,ko03036	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
HMBIOMIE_02309	8.07e-32	-	-	-	-	-	-	-	-
HMBIOMIE_02310	1.2e-30	ymzA	-	-	-	-	-	-	-
HMBIOMIE_02311	5.01e-66	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
HMBIOMIE_02312	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMBIOMIE_02313	1.65e-243	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMBIOMIE_02314	1.29e-140	-	-	-	-	-	-	-	-
HMBIOMIE_02315	5.49e-148	cwlC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
HMBIOMIE_02316	2.29e-226	spoVK	-	-	O	ko:K06413	-	ko00000	stage V sporulation protein K
HMBIOMIE_02317	4.47e-294	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMBIOMIE_02318	5.82e-311	ynbB	-	-	P	-	-	-	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
HMBIOMIE_02319	9.94e-90	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	transcriptional
HMBIOMIE_02320	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
HMBIOMIE_02321	1.57e-170	int	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HMBIOMIE_02322	6.02e-55	-	-	-	E	-	-	-	Zn peptidase
HMBIOMIE_02323	1.14e-33	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HMBIOMIE_02325	1.48e-31	-	-	-	-	-	-	-	-
HMBIOMIE_02327	9.02e-105	-	-	-	S	ko:K07741	-	ko00000	Phage regulatory protein Rha (Phage_pRha)
HMBIOMIE_02330	2.28e-108	-	-	-	L	-	-	-	DnaD domain protein
HMBIOMIE_02331	9.77e-18	-	-	-	S	-	-	-	Loader and inhibitor of phage G40P
HMBIOMIE_02332	1.33e-211	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	replicative DNA helicase
HMBIOMIE_02333	5.34e-31	-	-	-	-	-	-	-	-
HMBIOMIE_02334	6.08e-12	-	-	-	S	-	-	-	Phage-like element PBSX protein XtrA
HMBIOMIE_02335	0.000611	-	-	-	-	-	-	-	-
HMBIOMIE_02336	3.89e-66	-	-	-	M	-	-	-	ArpU family transcriptional regulator
HMBIOMIE_02340	6.68e-116	yrdC	-	-	Q	-	-	-	Isochorismatase family
HMBIOMIE_02342	2.02e-95	yvgO	-	-	-	-	-	-	-
HMBIOMIE_02343	2.17e-102	-	-	-	S	-	-	-	Domain of unknown function (DUF4868)
HMBIOMIE_02344	1.63e-56	-	-	-	-	-	-	-	-
HMBIOMIE_02345	2.89e-38	-	-	-	-	-	-	-	-
HMBIOMIE_02348	2.3e-64	-	-	-	V	ko:K07451	-	ko00000,ko01000,ko02048	HNH endonuclease
HMBIOMIE_02349	5.19e-102	-	-	-	L	-	-	-	phage terminase small subunit
HMBIOMIE_02350	0.0	-	-	-	S	-	-	-	Terminase
HMBIOMIE_02352	5.52e-220	-	-	-	S	-	-	-	Phage portal protein
HMBIOMIE_02353	5.33e-102	-	-	-	S	-	-	-	peptidase activity
HMBIOMIE_02354	1.29e-202	-	-	-	S	-	-	-	capsid protein
HMBIOMIE_02355	3.8e-34	-	-	-	-	-	-	-	-
HMBIOMIE_02356	6.93e-51	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HMBIOMIE_02357	3.02e-51	-	-	-	S	-	-	-	Phage head-tail joining protein
HMBIOMIE_02358	9.8e-66	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
HMBIOMIE_02360	5.6e-102	-	-	-	S	-	-	-	Phage tail tube protein
HMBIOMIE_02363	0.0	-	-	-	D	-	-	-	phage tail tape measure protein
HMBIOMIE_02364	2.06e-143	-	-	-	S	-	-	-	Phage tail protein
HMBIOMIE_02365	7.09e-278	acm2	3.2.1.17	-	NU	ko:K01185	-	ko00000,ko01000	Prophage endopeptidase tail
HMBIOMIE_02366	0.0	-	-	-	S	-	-	-	Peptidase_G2, IMC autoproteolytic cleavage domain
HMBIOMIE_02367	3.21e-144	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
HMBIOMIE_02370	6.25e-75	-	-	-	S	-	-	-	Bacteriophage holin family
HMBIOMIE_02371	1.07e-160	xlyB	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
HMBIOMIE_02372	9.44e-85	-	-	-	S	-	-	-	Immunity protein 70
HMBIOMIE_02373	6.56e-242	-	-	-	A	ko:K21491	-	ko00000,ko01000,ko02048	Pre-toxin TG
HMBIOMIE_02374	3.38e-138	rapK	-	-	S	ko:K06369	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
HMBIOMIE_02378	2.95e-14	-	-	-	-	-	-	-	-
HMBIOMIE_02379	2.61e-40	-	-	-	-	-	-	-	-
HMBIOMIE_02380	7.13e-52	-	-	-	-	-	-	-	-
HMBIOMIE_02381	5.4e-105	-	-	-	G	-	-	-	regulation of fungal-type cell wall biogenesis
HMBIOMIE_02382	1.97e-186	ynaC	-	-	-	-	-	-	-
HMBIOMIE_02383	7.56e-129	ynaD	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_02384	1.65e-160	-	-	-	S	-	-	-	Domain of unknown function (DUF3885)
HMBIOMIE_02385	1.06e-80	ynaF	-	-	-	-	-	-	-
HMBIOMIE_02386	4.5e-234	yaaC	-	-	S	-	-	-	YaaC-like Protein
HMBIOMIE_02387	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
HMBIOMIE_02388	2.81e-316	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HMBIOMIE_02389	3.7e-202	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HMBIOMIE_02390	1.66e-138	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HMBIOMIE_02391	9.79e-296	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMBIOMIE_02393	3.72e-159	dck	2.7.1.74, 2.7.1.76	-	F	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko01000	Deoxycytidine kinase
HMBIOMIE_02394	2.43e-150	dgk	2.7.1.113	-	F	ko:K15518	ko00230,map00230	ko00000,ko00001,ko01000	Deoxyguanosine kinase
HMBIOMIE_02395	7.7e-278	yaaH	-	-	M	ko:K06306	-	ko00000	Glycoside Hydrolase Family
HMBIOMIE_02396	1.44e-127	yaaI	-	-	Q	-	-	-	COG1335 Amidases related to nicotinamidase
HMBIOMIE_02397	1.55e-110	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HMBIOMIE_02398	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMBIOMIE_02399	8.75e-55	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMBIOMIE_02400	8.53e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMBIOMIE_02401	1.55e-42	yaaL	-	-	S	-	-	-	Protein of unknown function (DUF2508)
HMBIOMIE_02402	5.3e-49	bofA	-	-	S	ko:K06317	-	ko00000	Sigma-K factor-processing regulatory protein BofA
HMBIOMIE_02403	8.23e-215	ygxA	-	-	S	-	-	-	Nucleotidyltransferase-like
HMBIOMIE_02404	4.67e-75	ygzB	-	-	S	-	-	-	UPF0295 protein
HMBIOMIE_02405	2.37e-104	perR	-	-	P	ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
HMBIOMIE_02406	2.92e-113	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Peroxiredoxin
HMBIOMIE_02407	1.19e-314	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
HMBIOMIE_02408	1.87e-238	ygaE	-	-	S	-	-	-	Membrane
HMBIOMIE_02409	0.0	ygaD	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
HMBIOMIE_02410	8.1e-136	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
HMBIOMIE_02411	2.01e-49	ygaB	-	-	S	-	-	-	YgaB-like protein
HMBIOMIE_02412	2.35e-14	sspE	-	-	S	ko:K06422	-	ko00000	Small, acid-soluble spore protein, gamma-type
HMBIOMIE_02413	3.13e-172	fabL	1.3.1.104	-	IQ	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_02414	1.73e-48	yfhS	-	-	-	-	-	-	-
HMBIOMIE_02415	8.47e-268	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific
HMBIOMIE_02416	7.22e-237	yfhP	-	-	S	ko:K07038	-	ko00000	membrane-bound metal-dependent
HMBIOMIE_02417	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
HMBIOMIE_02418	3.43e-236	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
HMBIOMIE_02419	3.37e-219	yfhM	3.8.1.5	-	S	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Alpha beta hydrolase
HMBIOMIE_02420	5.4e-67	yfhL	-	-	S	-	-	-	SdpI/YhfL protein family
HMBIOMIE_02421	3.58e-119	yfhK	-	-	T	-	-	-	Bacterial SH3 domain homologues
HMBIOMIE_02422	8.95e-60	yfhJ	-	-	S	-	-	-	WVELL protein
HMBIOMIE_02423	2.25e-27	sspK	-	-	S	ko:K06428	-	ko00000	reproduction
HMBIOMIE_02424	2.45e-268	yfhI	-	-	EGP	-	-	-	-transporter
HMBIOMIE_02426	4.58e-69	yfhH	-	-	S	-	-	-	Protein of unknown function (DUF1811)
HMBIOMIE_02427	3.25e-181	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
HMBIOMIE_02428	1.13e-221	yfhF	-	-	S	ko:K07071	-	ko00000	nucleoside-diphosphate sugar epimerase
HMBIOMIE_02430	8.86e-35	yfhD	-	-	S	-	-	-	YfhD-like protein
HMBIOMIE_02431	2.87e-138	yfhC	-	-	C	-	-	-	nitroreductase
HMBIOMIE_02432	7.61e-215	yfhB	-	-	S	-	-	-	PhzF family
HMBIOMIE_02433	5.18e-229	yfhA	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_02434	1.54e-225	yfiZ	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_02435	2.81e-233	yfiY	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HMBIOMIE_02436	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMBIOMIE_02437	5.39e-106	yfiV	-	-	K	-	-	-	transcriptional
HMBIOMIE_02438	0.0	yfiU	-	-	EGP	-	-	-	the major facilitator superfamily
HMBIOMIE_02439	2.41e-129	yfiT	-	-	S	-	-	-	Belongs to the metal hydrolase YfiT family
HMBIOMIE_02440	4.51e-281	yfiS	-	-	EGP	-	-	-	Major facilitator superfamily
HMBIOMIE_02441	4.18e-141	yfiR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02442	2.29e-253	yfiQ	-	-	G	ko:K21462	-	ko00000	COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HMBIOMIE_02443	7.87e-128	lip	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HMBIOMIE_02444	1.89e-128	padR	-	-	K	-	-	-	transcriptional
HMBIOMIE_02445	4.56e-267	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
HMBIOMIE_02446	3.66e-274	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HMBIOMIE_02447	3.35e-218	drrA	-	-	V	ko:K01990,ko:K09695	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_02448	1.05e-146	yfiK	-	-	KT	ko:K02479	-	ko00000,ko02022	LuxR family transcriptional regulator
HMBIOMIE_02449	7.54e-276	baeS	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_02451	5.17e-295	-	-	-	S	-	-	-	Oxidoreductase
HMBIOMIE_02452	5.47e-234	-	-	-	G	-	-	-	Xylose isomerase
HMBIOMIE_02453	0.0	yfiG	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_02454	1.28e-228	-	-	-	K	ko:K02099	-	ko00000,ko03000	AraC-like ligand binding domain
HMBIOMIE_02455	7.28e-209	yfiE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
HMBIOMIE_02456	2.01e-84	yfiD3	-	-	S	-	-	-	DoxX
HMBIOMIE_02457	0.0	yfiC3	-	-	V	ko:K06147	-	ko00000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
HMBIOMIE_02458	0.0	yfiB3	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HMBIOMIE_02459	0.0	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_02460	7.45e-182	-	-	-	K	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
HMBIOMIE_02461	0.0	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HMBIOMIE_02462	5.59e-61	yfjA	-	-	S	-	-	-	Belongs to the WXG100 family
HMBIOMIE_02463	1.94e-270	yfjB	-	-	-	-	-	-	-
HMBIOMIE_02464	2.5e-185	yfjC	-	-	-	-	-	-	-
HMBIOMIE_02465	1.49e-131	yfjD	-	-	S	-	-	-	Family of unknown function (DUF5381)
HMBIOMIE_02466	1.53e-104	-	-	-	S	-	-	-	Family of unknown function (DUF5381)
HMBIOMIE_02467	7.42e-75	yfjF	-	-	S	ko:K09771	-	ko00000,ko02000	UPF0060 membrane protein
HMBIOMIE_02468	8.16e-36	sspH	-	-	S	ko:K06425	-	ko00000	Belongs to the SspH family
HMBIOMIE_02469	0.0	acoR	-	-	KQ	ko:K21405	-	ko00000,ko03000	COG3284 Transcriptional activator of acetoin glycerol metabolism
HMBIOMIE_02470	0.0	acoL	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
HMBIOMIE_02471	4.19e-265	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HMBIOMIE_02472	2.75e-244	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
HMBIOMIE_02473	1.36e-244	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
HMBIOMIE_02475	7.56e-108	yfjM	-	-	S	-	-	-	Psort location Cytoplasmic, score
HMBIOMIE_02476	6.18e-237	yfjN	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMBIOMIE_02477	3e-53	-	-	-	S	-	-	-	YfzA-like protein
HMBIOMIE_02478	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMBIOMIE_02479	1.94e-214	yfjP	3.2.2.21	-	L	ko:K01247	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HMBIOMIE_02480	7.8e-237	corA	-	-	P	ko:K03284	-	ko00000,ko02000	Mediates influx of magnesium ions
HMBIOMIE_02481	1.32e-191	yfjR	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
HMBIOMIE_02482	5.95e-197	pdaA	-	-	G	ko:K01567	-	ko00000,ko01000	deacetylase
HMBIOMIE_02483	3.26e-36	yfjT	-	-	-	-	-	-	-
HMBIOMIE_02484	1.76e-283	yfkA	-	-	S	-	-	-	YfkB-like domain
HMBIOMIE_02485	1.49e-189	yfkC	-	-	M	-	-	-	Mechanosensitive ion channel
HMBIOMIE_02486	3.69e-189	yfkD	-	-	S	-	-	-	YfkD-like protein
HMBIOMIE_02487	5.44e-235	cax	-	-	P	ko:K07300	-	ko00000,ko02000	COG0387 Ca2 H antiporter
HMBIOMIE_02488	3.84e-278	yfkF	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_02489	1.64e-12	-	-	-	-	-	-	-	-
HMBIOMIE_02490	1.6e-182	yihY	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
HMBIOMIE_02491	1.03e-66	yfkI	-	-	S	-	-	-	gas vesicle protein
HMBIOMIE_02492	9.78e-107	yfkJ	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMBIOMIE_02493	7.27e-42	yfkK	-	-	S	-	-	-	Belongs to the UPF0435 family
HMBIOMIE_02494	2.53e-265	ydiN3	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_02495	7.78e-114	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
HMBIOMIE_02496	0.0	yfkN	3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45	-	F	ko:K01081,ko:K01119,ko:K06931,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HMBIOMIE_02497	6.16e-160	frp	-	-	C	-	-	-	nitroreductase
HMBIOMIE_02498	1.24e-172	treR	-	-	K	ko:K03486	-	ko00000,ko03000	transcriptional
HMBIOMIE_02499	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
HMBIOMIE_02500	0.0	treP	2.7.1.201	-	G	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_02501	0.0	yfkQ	-	-	EG	ko:K06295,ko:K06307	-	ko00000	Spore germination protein
HMBIOMIE_02502	2.28e-271	yfkR	-	-	S	ko:K06297,ko:K06308	-	ko00000	spore germination
HMBIOMIE_02504	2.19e-249	yfkT	-	-	E	ko:K06309	-	ko00000	Spore germination protein
HMBIOMIE_02505	0.0	yflA	-	-	E	ko:K03310	-	ko00000	Sodium alanine symporter
HMBIOMIE_02506	1.89e-87	ydhN1	-	-	S	-	-	-	Domain of unknown function (DUF1992)
HMBIOMIE_02507	0.0	yflE	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
HMBIOMIE_02508	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
HMBIOMIE_02509	1.14e-178	yflG	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
HMBIOMIE_02510	3.63e-66	yflH	-	-	S	-	-	-	Protein of unknown function (DUF3243)
HMBIOMIE_02511	6.9e-27	yflI	-	-	-	-	-	-	-
HMBIOMIE_02512	1.1e-25	yflJ	-	-	S	-	-	-	Protein of unknown function (DUF2639)
HMBIOMIE_02513	2.51e-159	yflK	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02514	2.54e-60	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
HMBIOMIE_02515	1.43e-277	nos	1.14.14.47	-	C	ko:K00491	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HMBIOMIE_02516	7.21e-194	yflN	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
HMBIOMIE_02517	1.53e-287	citM	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
HMBIOMIE_02518	1.97e-230	yflP	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
HMBIOMIE_02519	3.96e-154	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HMBIOMIE_02520	0.0	citS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
HMBIOMIE_02521	0.0	yflS	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
HMBIOMIE_02522	2.45e-307	pel	4.2.2.2	-	G	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectate lyase
HMBIOMIE_02523	1.71e-76	yflT	-	-	S	-	-	-	Heat induced stress protein YflT
HMBIOMIE_02524	1.06e-31	-	-	-	S	-	-	-	Protein of unknown function (DUF3212)
HMBIOMIE_02525	3.36e-220	yfmC	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
HMBIOMIE_02526	4.72e-220	-	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_02527	2.73e-219	fecD	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_02528	1.4e-192	fhuC	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
HMBIOMIE_02529	0.0	pkn1	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
HMBIOMIE_02530	3.46e-268	-	-	-	G	-	-	-	Major Facilitator Superfamily
HMBIOMIE_02531	4.21e-242	yfmJ	-	-	S	ko:K07119	-	ko00000	N-terminal domain of oxidoreductase
HMBIOMIE_02532	1.86e-107	yfmK	2.3.1.128	-	K	ko:K03790	-	ko00000,ko01000,ko03009	acetyltransferase
HMBIOMIE_02533	1.86e-266	yfmL	-	-	L	-	-	-	COG0513 Superfamily II DNA and RNA helicases
HMBIOMIE_02534	0.0	yheS_1	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMBIOMIE_02535	3.59e-265	yfmO	-	-	EGP	ko:K08221	-	ko00000,ko02000	Major facilitator superfamily
HMBIOMIE_02536	3.54e-90	yfmP	-	-	K	ko:K21902	-	ko00000,ko03000	transcriptional
HMBIOMIE_02537	6.23e-97	yfmQ	-	-	S	-	-	-	Uncharacterised protein from bacillus cereus group
HMBIOMIE_02538	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
HMBIOMIE_02539	5.14e-161	yfmS	-	-	NT	-	-	-	chemotaxis protein
HMBIOMIE_02540	0.0	yfmT	1.2.1.3, 1.2.1.67	-	C	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMBIOMIE_02541	3.41e-312	yfnA	-	-	E	ko:K03294	-	ko00000	amino acid
HMBIOMIE_02542	3.03e-167	yfnB	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HMBIOMIE_02543	1.06e-186	fsr	-	-	P	ko:K08223	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_02544	3.34e-55	fsr	-	-	P	ko:K08223	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_02545	2.34e-243	yfnD	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
HMBIOMIE_02546	2.44e-286	yfnE	-	-	S	-	-	-	Glycosyltransferase like family 2
HMBIOMIE_02547	9.79e-232	yfnF	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
HMBIOMIE_02548	4.79e-220	yfnG	4.2.1.45, 4.2.1.46	-	M	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	dehydratase
HMBIOMIE_02549	2.15e-190	yfnH	2.7.7.33	-	JM	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	ko00000,ko00001,ko01000	Nucleotidyl transferase
HMBIOMIE_02550	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
HMBIOMIE_02551	0.0	cypD	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
HMBIOMIE_02552	6.1e-255	yetN	-	-	S	-	-	-	Protein of unknown function (DUF3900)
HMBIOMIE_02553	4.77e-270	yetM	-	-	CH	-	-	-	FAD binding domain
HMBIOMIE_02554	6.74e-117	yetL	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_02555	7.35e-203	-	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_02556	2.55e-135	yetJ	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
HMBIOMIE_02557	3.81e-28	yezD	-	-	S	-	-	-	Uncharacterized small protein (DUF2292)
HMBIOMIE_02558	1.97e-54	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMBIOMIE_02559	3.87e-114	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMBIOMIE_02560	9.79e-45	-	-	-	-	-	-	-	-
HMBIOMIE_02561	2.47e-85	yetH	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_02562	4.67e-73	yetG	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
HMBIOMIE_02563	3.13e-158	yetF	-	-	S	-	-	-	membrane
HMBIOMIE_02564	0.0	-	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
HMBIOMIE_02565	7.85e-209	-	-	-	G	ko:K17320	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_02566	1.01e-227	lplB	-	-	G	ko:K17319	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4209 ABC-type polysaccharide transport system, permease component
HMBIOMIE_02567	0.0	lplA	-	-	G	ko:K17318	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HMBIOMIE_02568	0.0	yetA	-	-	-	-	-	-	-
HMBIOMIE_02569	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
HMBIOMIE_02570	9.13e-160	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HMBIOMIE_02571	0.0	yesX	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
HMBIOMIE_02572	0.0	-	4.2.2.23, 4.2.2.24	PL11	E	ko:K18197,ko:K18198	-	ko00000,ko01000	cell wall organization
HMBIOMIE_02573	9.47e-144	-	-	-	S	-	-	-	Protein of unknown function, DUF624
HMBIOMIE_02574	1.07e-164	yesU	-	-	S	-	-	-	Domain of unknown function (DUF1961)
HMBIOMIE_02575	2.59e-164	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HMBIOMIE_02576	0.0	yesS	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02577	8e-254	-	3.2.1.172	GH105	S	ko:K15532	-	ko00000,ko01000	Glycosyl Hydrolase Family 88
HMBIOMIE_02578	5.11e-210	-	-	-	P	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_02579	2.02e-218	yesP	-	-	G	ko:K02025	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_02580	9.72e-313	yesO	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HMBIOMIE_02581	1.14e-256	-	-	-	K	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
HMBIOMIE_02582	0.0	yesM	2.7.13.3	-	T	ko:K07718	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_02583	1.95e-132	yesL	-	-	S	-	-	-	Protein of unknown function, DUF624
HMBIOMIE_02584	2.4e-130	yesJ	-	-	K	-	-	-	Acetyltransferase (GNAT) family
HMBIOMIE_02585	1.04e-133	cotJC	-	-	P	ko:K06334	-	ko00000	Spore Coat
HMBIOMIE_02586	2.31e-61	cotJB	-	-	S	ko:K06333	-	ko00000	CotJB protein
HMBIOMIE_02587	3.8e-60	cotJA	-	-	S	ko:K06332	-	ko00000	Spore coat associated protein JA (CotJA)
HMBIOMIE_02588	1.23e-195	yesF	-	-	GM	-	-	-	NAD(P)H-binding
HMBIOMIE_02589	3.35e-105	yesE	-	-	S	ko:K06893	-	ko00000	SnoaL-like domain
HMBIOMIE_02590	1.86e-134	dhaR3	-	-	K	ko:K16137	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_02592	6.29e-162	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
HMBIOMIE_02594	1.22e-271	rapH	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Tetratricopeptide repeat
HMBIOMIE_02595	4.24e-14	-	-	-	S	-	-	-	Pfam:DUF1311
HMBIOMIE_02596	3.52e-71	-	-	-	-	-	-	-	-
HMBIOMIE_02597	8.81e-155	-	3.4.24.40	-	CO	ko:K01406	ko01503,map01503	ko00000,ko00001,ko01000,ko01002	amine dehydrogenase activity
HMBIOMIE_02599	0.0	-	-	-	L	-	-	-	nucleic acid phosphodiester bond hydrolysis
HMBIOMIE_02600	2.1e-109	-	-	-	S	-	-	-	Protein of unknown function, DUF600
HMBIOMIE_02601	4.15e-42	-	-	-	S	-	-	-	Colicin immunity protein / pyocin immunity protein
HMBIOMIE_02602	7.48e-05	-	-	-	-	-	-	-	-
HMBIOMIE_02603	1.13e-270	yeeC	-	-	P	-	-	-	T5orf172
HMBIOMIE_02604	0.0	-	-	-	L	-	-	-	DEAD-like helicases superfamily
HMBIOMIE_02605	0.0	yeeA	-	-	V	-	-	-	Type II restriction enzyme, methylase subunits
HMBIOMIE_02606	5.61e-71	-	-	-	L	-	-	-	Resolvase, N terminal domain
HMBIOMIE_02607	3.63e-127	-	-	-	L	-	-	-	Recombinase
HMBIOMIE_02608	0.0	rlmCD	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMBIOMIE_02609	1.8e-218	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
HMBIOMIE_02610	0.0	swrC	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMBIOMIE_02611	2.93e-201	yerO	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02612	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMBIOMIE_02613	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HMBIOMIE_02614	7.37e-61	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMBIOMIE_02615	0.0	putP	-	-	E	ko:K03307,ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMBIOMIE_02616	2.29e-160	sapB	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
HMBIOMIE_02617	6.28e-253	yerI	-	-	S	-	-	-	homoserine kinase type II (protein kinase fold)
HMBIOMIE_02618	1.77e-281	camS	-	-	S	-	-	-	COG4851 Protein involved in sex pheromone biosynthesis
HMBIOMIE_02619	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMBIOMIE_02620	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
HMBIOMIE_02621	1.1e-161	pcrB	-	-	I	ko:K07094	-	ko00000,ko01000	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HMBIOMIE_02623	0.0	yerD	1.4.7.1	-	E	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	ko00000,ko00001,ko01000	Belongs to the glutamate synthase family
HMBIOMIE_02624	7.62e-68	yerC	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02625	7.03e-246	yerB	-	-	S	-	-	-	Protein of unknown function (DUF3048) C-terminal domain
HMBIOMIE_02626	0.0	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
HMBIOMIE_02627	3.45e-37	-	-	-	S	-	-	-	Protein of unknown function (DUF2892)
HMBIOMIE_02628	1.91e-297	-	-	-	E	ko:K16263	-	ko00000,ko02000	Amino acid permease
HMBIOMIE_02629	5.26e-96	-	-	-	K	-	-	-	helix_turn_helix ASNC type
HMBIOMIE_02630	2.07e-300	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
HMBIOMIE_02631	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
HMBIOMIE_02632	8.88e-138	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMBIOMIE_02633	1.4e-239	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
HMBIOMIE_02634	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMBIOMIE_02635	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMBIOMIE_02636	1.15e-167	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMBIOMIE_02637	3.79e-52	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMBIOMIE_02638	1.06e-170	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
HMBIOMIE_02639	2.81e-314	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMBIOMIE_02640	9.39e-278	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMBIOMIE_02641	2.28e-108	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMBIOMIE_02642	3.13e-38	yebG	-	-	S	-	-	-	NETI protein
HMBIOMIE_02643	2.66e-120	yebE	-	-	S	-	-	-	UPF0316 protein
HMBIOMIE_02645	1.44e-165	yebC	-	-	M	-	-	-	Membrane
HMBIOMIE_02646	1.2e-283	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HMBIOMIE_02647	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4179)
HMBIOMIE_02648	7.14e-117	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_02649	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
HMBIOMIE_02650	0.0	yebA	-	-	E	-	-	-	COG1305 Transglutaminase-like enzymes
HMBIOMIE_02651	6.74e-287	yeaD	-	-	S	-	-	-	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
HMBIOMIE_02652	1.18e-227	yeaC	-	-	S	ko:K03924	-	ko00000,ko01000	COG0714 MoxR-like ATPases
HMBIOMIE_02653	6.13e-199	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMBIOMIE_02654	0.0	gabP	-	-	E	ko:K11735	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_02655	0.0	cotA	1.16.3.3	-	Q	ko:K06324	-	ko00000,ko01000	multicopper oxidases
HMBIOMIE_02656	1.96e-226	yeaA	-	-	S	-	-	-	Protein of unknown function (DUF4003)
HMBIOMIE_02657	2.08e-201	-	-	-	I	-	-	-	Alpha/beta hydrolase family
HMBIOMIE_02658	8.2e-48	ydjO	-	-	S	-	-	-	Cold-inducible protein YdjO
HMBIOMIE_02660	4.18e-210	ydjN	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
HMBIOMIE_02661	1.79e-84	ydjM	-	-	M	-	-	-	Lytic transglycolase
HMBIOMIE_02662	3.5e-249	ydjL	1.1.1.264, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00098	ko00650,map00650	ko00000,ko00001,ko01000	Dehydrogenase
HMBIOMIE_02663	0.0	iolT	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_02664	1.95e-248	-	-	-	S	-	-	-	Ion transport 2 domain protein
HMBIOMIE_02665	1.79e-203	ydjI	-	-	S	-	-	-	virion core protein (lumpy skin disease virus)
HMBIOMIE_02666	1.61e-176	ydjH	-	-	S	ko:K06872	-	ko00000	COG1512 Beta-propeller domains of methanol dehydrogenase type
HMBIOMIE_02667	1.04e-227	ydjG	-	-	L	-	-	-	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMBIOMIE_02668	5.36e-148	pspA	-	-	KT	ko:K03969	-	ko00000	Phage shock protein A
HMBIOMIE_02669	5.39e-224	ydjE	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HMBIOMIE_02670	0.0	gutP	-	-	G	ko:K03292,ko:K16248	-	ko00000,ko02000	MFS/sugar transport protein
HMBIOMIE_02671	1.06e-258	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
HMBIOMIE_02672	0.0	gutR	-	-	K	ko:K16247	-	ko00000,ko03000	NB-ARC domain
HMBIOMIE_02673	3.73e-11	ydjC	-	-	S	-	-	-	Abhydrolase domain containing 18
HMBIOMIE_02674	0.0	-	-	-	J	-	-	-	LlaJI restriction endonuclease
HMBIOMIE_02675	3.67e-254	-	-	-	V	-	-	-	AAA domain (dynein-related subfamily)
HMBIOMIE_02677	1.43e-297	-	2.1.1.37	-	H	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HMBIOMIE_02678	0.0	dcm	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	DNA (cytosine-5-)-methyltransferase activity
HMBIOMIE_02679	6.93e-88	-	-	-	KL	ko:K06919	-	ko00000	Phage plasmid primase P4 family
HMBIOMIE_02681	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HMBIOMIE_02682	2.14e-58	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMBIOMIE_02683	3e-167	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HMBIOMIE_02684	3.2e-37	ydiK	-	-	S	-	-	-	Domain of unknown function (DUF4305)
HMBIOMIE_02685	8.73e-162	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMBIOMIE_02686	5.48e-31	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
HMBIOMIE_02687	2.14e-148	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HMBIOMIE_02688	1.46e-117	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
HMBIOMIE_02689	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
HMBIOMIE_02690	1.63e-241	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMBIOMIE_02691	1.71e-109	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
HMBIOMIE_02692	1.76e-163	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214 Inactive homolog of metal-dependent proteases
HMBIOMIE_02693	9.02e-113	ydiB	-	-	S	ko:K06925	-	ko00000,ko03016	ATPase or kinase
HMBIOMIE_02694	3.06e-237	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HMBIOMIE_02703	1.25e-10	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMBIOMIE_02704	3.31e-11	-	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02705	5.29e-47	-	-	-	S	-	-	-	YolD-like protein
HMBIOMIE_02707	1.06e-260	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Aspartate phosphatase response regulator
HMBIOMIE_02708	0.0	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HMBIOMIE_02709	1.38e-73	-	-	-	S	ko:K21488	-	ko00000,ko02048	SMI1-KNR4 cell-wall
HMBIOMIE_02710	1.19e-159	xlyB	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
HMBIOMIE_02711	3.19e-41	xhlB	-	-	S	-	-	-	SPP1 phage holin
HMBIOMIE_02712	1.62e-45	xhlA	-	-	S	-	-	-	Haemolysin XhlA
HMBIOMIE_02713	1.78e-190	xepA	-	-	-	-	-	-	-
HMBIOMIE_02714	4.17e-27	-	-	-	-	-	-	-	-
HMBIOMIE_02715	1.73e-56	xkdW	-	-	S	-	-	-	XkdW protein
HMBIOMIE_02716	7.02e-212	-	-	-	-	-	-	-	-
HMBIOMIE_02717	1.33e-48	-	-	-	-	-	-	-	-
HMBIOMIE_02718	3.33e-127	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
HMBIOMIE_02719	4.31e-235	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
HMBIOMIE_02720	3.52e-86	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
HMBIOMIE_02721	3.46e-43	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
HMBIOMIE_02722	1.33e-227	xkdQ	-	-	G	-	-	-	NLP P60 protein
HMBIOMIE_02723	7.44e-151	xkdP	-	-	S	-	-	-	Lysin motif
HMBIOMIE_02724	0.0	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
HMBIOMIE_02725	5.44e-22	-	-	-	-	-	-	-	-
HMBIOMIE_02726	1.04e-88	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
HMBIOMIE_02727	8.21e-97	xkdM	-	-	S	-	-	-	Phage tail tube protein
HMBIOMIE_02728	2.91e-311	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
HMBIOMIE_02729	2.02e-31	-	-	-	-	-	-	-	-
HMBIOMIE_02730	2.86e-87	yqbJ	-	-	-	-	-	-	-
HMBIOMIE_02731	3.75e-114	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
HMBIOMIE_02732	3.26e-61	-	-	-	S	-	-	-	Protein of unknown function (DUF3199)
HMBIOMIE_02733	3.4e-30	-	-	-	S	-	-	-	YqbF, hypothetical protein domain
HMBIOMIE_02734	2.12e-189	xkdG	-	-	S	-	-	-	Phage capsid family
HMBIOMIE_02735	2.17e-128	yqbD	-	-	L	-	-	-	Putative phage serine protease XkdF
HMBIOMIE_02737	2.75e-182	-	-	-	S	-	-	-	Phage Mu protein F like protein
HMBIOMIE_02738	7.34e-316	yqbA	-	-	S	-	-	-	portal protein
HMBIOMIE_02739	1.46e-295	yqaT	-	-	S	ko:K06909	-	ko00000	phage terminase, large subunit
HMBIOMIE_02740	1.11e-103	-	-	-	-	-	-	-	-
HMBIOMIE_02741	6.96e-36	-	-	-	-	-	-	-	-
HMBIOMIE_02742	2.13e-160	-	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HMBIOMIE_02743	6.48e-71	-	-	-	K	-	-	-	DNA binding
HMBIOMIE_02746	3.56e-05	-	-	-	-	-	-	-	-
HMBIOMIE_02748	1.73e-50	-	-	-	-	-	-	-	-
HMBIOMIE_02749	3.07e-76	-	-	-	-	-	-	-	-
HMBIOMIE_02752	1.68e-238	-	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
HMBIOMIE_02755	7.84e-34	-	-	-	-	-	-	-	-
HMBIOMIE_02757	4.12e-26	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3850)
HMBIOMIE_02759	1.75e-97	-	-	-	-	-	-	-	-
HMBIOMIE_02760	3.41e-62	-	3.1.22.4	-	-	ko:K01159	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	-
HMBIOMIE_02763	5.3e-227	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HMBIOMIE_02765	1.13e-33	-	-	-	L	-	-	-	primosome component and related proteins
HMBIOMIE_02767	2.42e-131	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
HMBIOMIE_02768	2.55e-146	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
HMBIOMIE_02770	6.67e-229	-	-	-	D	-	-	-	nuclear chromosome segregation
HMBIOMIE_02774	3.29e-57	-	-	-	-	-	-	-	-
HMBIOMIE_02775	1e-15	-	-	-	S	-	-	-	Helix-turn-helix domain
HMBIOMIE_02777	1.41e-23	-	-	-	K	-	-	-	Helix-turn-helix domain
HMBIOMIE_02779	6.36e-32	xkdA	-	-	E	-	-	-	IrrE N-terminal-like domain
HMBIOMIE_02780	1.43e-100	-	-	-	L	-	-	-	Phage integrase, N-terminal SAM-like domain
HMBIOMIE_02783	2.52e-122	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter protein (Thia_YuaJ)
HMBIOMIE_02784	1.2e-122	-	-	-	M	-	-	-	FR47-like protein
HMBIOMIE_02785	4.54e-258	yuaG	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	protein conserved in bacteria
HMBIOMIE_02786	4.06e-110	yuaF	-	-	OU	-	-	-	Membrane protein implicated in regulation of membrane protease activity
HMBIOMIE_02787	1.95e-109	yuaE	-	-	S	-	-	-	DinB superfamily
HMBIOMIE_02788	8.58e-139	yuaD	-	-	-	-	-	-	-
HMBIOMIE_02789	4.26e-292	gbsB	1.1.1.1	-	C	ko:K11440	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
HMBIOMIE_02790	0.0	gbsA	1.2.1.8	-	C	ko:K00130	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HMBIOMIE_02791	3.53e-123	yuaC	-	-	K	ko:K22109	-	ko00000,ko03000	Belongs to the GbsR family
HMBIOMIE_02792	5.83e-118	yuaB	-	-	-	-	-	-	-
HMBIOMIE_02793	1.83e-157	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
HMBIOMIE_02794	1.85e-301	-	-	-	P	ko:K03498	-	ko00000,ko02000	Potassium
HMBIOMIE_02795	3.31e-52	yubF	-	-	S	-	-	-	yiaA/B two helix domain
HMBIOMIE_02796	1.87e-196	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HMBIOMIE_02797	0.0	yubD	-	-	P	-	-	-	Major Facilitator Superfamily
HMBIOMIE_02798	6.82e-114	cdoA	1.13.11.20	-	S	ko:K00456	ko00270,ko00430,ko01100,map00270,map00430,map01100	ko00000,ko00001,ko01000	Cysteine dioxygenase type I
HMBIOMIE_02800	6.02e-183	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HMBIOMIE_02801	3.8e-256	yubA	-	-	S	-	-	-	transporter activity
HMBIOMIE_02802	9.11e-236	yulF	-	-	S	ko:K22230	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
HMBIOMIE_02803	0.0	rhaA	2.7.1.5, 5.3.1.14	-	G	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Belongs to the rhamnose isomerase family
HMBIOMIE_02804	4.94e-73	rhaM	5.1.3.32	-	G	ko:K03534	-	ko00000,ko01000	Involved in the anomeric conversion of L-rhamnose
HMBIOMIE_02805	0.0	rhaB	2.7.1.5	-	G	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	ko00000,ko00001,ko01000	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
HMBIOMIE_02806	1.42e-172	yulB	-	-	K	ko:K02530,ko:K22103	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
HMBIOMIE_02807	0.0	yuxG	-	-	IQ	-	-	-	Class II Aldolase and Adducin N-terminal domain
HMBIOMIE_02808	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_02809	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_02810	6.34e-300	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_02811	0.0	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_02812	1.06e-181	tgl	2.3.2.13	-	H	ko:K00686	-	ko00000,ko01000	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
HMBIOMIE_02813	5e-48	-	-	-	-	-	-	-	-
HMBIOMIE_02814	3.63e-95	yugU	-	-	S	-	-	-	Uncharacterised protein family UPF0047
HMBIOMIE_02815	0.0	yugT	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
HMBIOMIE_02816	1.25e-300	yugS	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
HMBIOMIE_02817	4.8e-150	yugP	-	-	S	ko:K06973	-	ko00000	Zn-dependent protease
HMBIOMIE_02818	1.35e-51	-	-	-	-	-	-	-	-
HMBIOMIE_02819	2.12e-70	mstX	-	-	S	-	-	-	Membrane-integrating protein Mistic
HMBIOMIE_02820	1.76e-233	yugO	-	-	P	ko:K10716	-	ko00000,ko02000	COG1226 Kef-type K transport systems
HMBIOMIE_02821	4.22e-95	yugN	-	-	S	-	-	-	YugN-like family
HMBIOMIE_02823	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
HMBIOMIE_02824	5.56e-291	yugK	-	-	C	ko:K19955	-	ko00000,ko01000	Dehydrogenase
HMBIOMIE_02825	8.16e-287	yugJ	-	-	C	ko:K19955	-	ko00000,ko01000	oxidoreductases, Fe-dependent alcohol dehydrogenase family
HMBIOMIE_02826	2.21e-46	yuzA	-	-	S	ko:K09779	-	ko00000	Domain of unknown function (DUF378)
HMBIOMIE_02827	5e-83	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
HMBIOMIE_02828	5.43e-255	yugH	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Aminotransferase
HMBIOMIE_02829	6.74e-112	alaR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02830	4.03e-200	yugF	-	-	I	-	-	-	Hydrolase
HMBIOMIE_02831	8.84e-52	yugE	-	-	S	-	-	-	Domain of unknown function (DUF1871)
HMBIOMIE_02832	1.21e-288	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
HMBIOMIE_02833	6.96e-295	kinB2	2.7.13.3	-	T	ko:K07697	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_02834	4.3e-92	kapB	-	-	G	ko:K06347	ko02020,map02020	ko00000,ko00001	Kinase associated protein B
HMBIOMIE_02835	8.49e-150	kapD	-	-	L	ko:K06348	-	ko00000	the KinA pathway to sporulation
HMBIOMIE_02837	1.96e-245	yuxJ	-	-	EGP	-	-	-	Major facilitator superfamily
HMBIOMIE_02838	0.0	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
HMBIOMIE_02839	3.31e-98	yuxK	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02840	4.19e-113	yufK	-	-	S	-	-	-	Family of unknown function (DUF5366)
HMBIOMIE_02841	0.0	malK	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
HMBIOMIE_02842	1.14e-162	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
HMBIOMIE_02843	6.34e-254	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
HMBIOMIE_02844	0.0	yufO	3.6.3.17	-	S	ko:K02056	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_02845	1.57e-237	yufP	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HMBIOMIE_02846	1.47e-216	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HMBIOMIE_02847	9.73e-310	malP	-	-	C	ko:K11616	ko02020,map02020	ko00000,ko00001	COG3493 Na citrate symporter
HMBIOMIE_02848	7.06e-22	-	-	-	-	-	-	-	-
HMBIOMIE_02849	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
HMBIOMIE_02850	7.66e-91	mrpB	-	-	P	ko:K05566	-	ko00000,ko02000	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMBIOMIE_02851	1.72e-66	mrpC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMBIOMIE_02852	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMBIOMIE_02853	2.12e-102	mrpE	-	-	P	ko:K05569	-	ko00000,ko02000	Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMBIOMIE_02854	2.23e-51	mrpF	-	-	P	ko:K05570	-	ko00000,ko02000	Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
HMBIOMIE_02855	5.74e-77	mrpG	-	-	P	ko:K05571	-	ko00000,ko02000	COG1320 Multisubunit Na H antiporter, MnhG subunit
HMBIOMIE_02856	3.18e-84	yuxO	-	-	Q	-	-	-	protein, possibly involved in aromatic compounds catabolism
HMBIOMIE_02857	2.06e-150	comA	-	-	K	ko:K07691	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_02858	0.0	comP	2.7.13.3	-	T	ko:K07680	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_02860	4.93e-183	comQ	-	-	H	ko:K02251	ko02024,map02024	ko00000,ko00001,ko02044	Belongs to the FPP GGPP synthase family
HMBIOMIE_02861	6.29e-10	-	-	-	S	-	-	-	DegQ (SacQ) family
HMBIOMIE_02862	8.73e-09	yuzC	-	-	-	-	-	-	-
HMBIOMIE_02863	1.39e-296	yuxH	-	-	T	-	-	-	signal transduction protein containing EAL and modified HD-GYP domains
HMBIOMIE_02864	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMBIOMIE_02865	5.65e-135	pncA	-	-	Q	ko:K16788	-	ko00000,ko02000	COG1335 Amidases related to nicotinamidase
HMBIOMIE_02866	1.08e-87	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HMBIOMIE_02867	1.63e-52	yueH	-	-	S	-	-	-	YueH-like protein
HMBIOMIE_02868	7.15e-43	yueG	-	-	S	ko:K06299	-	ko00000	Spore germination protein gerPA/gerPF
HMBIOMIE_02869	1.35e-244	yueF	-	-	S	-	-	-	transporter activity
HMBIOMIE_02870	1.44e-86	-	-	-	S	-	-	-	Protein of unknown function (DUF2283)
HMBIOMIE_02871	8.4e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
HMBIOMIE_02872	1.91e-125	yueE	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
HMBIOMIE_02873	3.53e-170	yueD	1.1.1.320	-	IQ	ko:K16216	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_02874	7.25e-96	yueC	-	-	S	-	-	-	Family of unknown function (DUF5383)
HMBIOMIE_02875	0.0	yueB	-	-	S	-	-	-	type VII secretion protein EsaA
HMBIOMIE_02876	0.0	essC	-	-	D	ko:K03466	-	ko00000,ko03036	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
HMBIOMIE_02877	4.28e-271	essB	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukC
HMBIOMIE_02878	1.93e-54	yukD	-	-	S	-	-	-	WXG100 protein secretion system (Wss), protein YukD
HMBIOMIE_02879	3.93e-60	yukE	-	-	S	-	-	-	Belongs to the WXG100 family
HMBIOMIE_02880	1.03e-292	yukF	-	-	QT	-	-	-	Transcriptional regulator
HMBIOMIE_02881	4.02e-262	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
HMBIOMIE_02882	1.2e-168	yukJ	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2278)
HMBIOMIE_02883	2.02e-47	mbtH	-	-	S	ko:K05375	ko00261,ko01130,map00261,map01130	ko00000,ko00001,ko00002	MbtH-like protein
HMBIOMIE_02884	0.0	dhbF	-	-	Q	ko:K04780	ko01053,map01053	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_02885	1.56e-228	dhbB	3.3.2.1, 6.3.2.14	-	Q	ko:K01252	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	Isochorismatase family
HMBIOMIE_02886	0.0	entE	2.7.7.58, 6.3.2.14	-	Q	ko:K02363,ko:K04783	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	2,3-dihydroxybenzoate-AMP ligase
HMBIOMIE_02887	5.78e-288	dhbC	5.4.4.2	-	HQ	ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
HMBIOMIE_02888	5.83e-178	dhbA	1.3.1.28	-	IQ	ko:K00216	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_02889	1.04e-211	eSD	-	-	S	ko:K07017	-	ko00000	Putative esterase
HMBIOMIE_02890	2.36e-157	yuiH	-	-	S	-	-	-	Oxidoreductase molybdopterin binding domain
HMBIOMIE_02891	1.18e-124	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Biotin biosynthesis protein
HMBIOMIE_02892	1.48e-278	yuiF	-	-	S	ko:K07084	-	ko00000,ko02000	antiporter
HMBIOMIE_02893	0.0	pepA	3.4.11.1	-	E	ko:K01255	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMBIOMIE_02894	8.63e-102	yuiD	-	-	S	ko:K09775	-	ko00000	protein conserved in bacteria
HMBIOMIE_02895	1.69e-151	yuiC	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02896	9.78e-47	yuiB	-	-	S	-	-	-	Putative membrane protein
HMBIOMIE_02897	4.16e-301	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HMBIOMIE_02898	1.16e-240	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	reductase
HMBIOMIE_02900	1.15e-237	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HMBIOMIE_02901	2.96e-151	paiB	-	-	K	ko:K07734	-	ko00000,ko03000	Putative FMN-binding domain
HMBIOMIE_02902	6.88e-116	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_02903	6.81e-83	erpA	-	-	S	ko:K13628	-	ko00000,ko03016	Belongs to the HesB IscA family
HMBIOMIE_02904	3.9e-208	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMBIOMIE_02905	1.54e-270	yutK	-	-	F	ko:K03317	-	ko00000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMBIOMIE_02906	1.74e-52	yuzB	-	-	S	-	-	-	Belongs to the UPF0349 family
HMBIOMIE_02907	1.12e-253	yutJ	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HMBIOMIE_02908	6.61e-75	yuzD	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02909	1.26e-47	yutI	-	-	O	-	-	-	COG0694 Thioredoxin-like proteins and domains
HMBIOMIE_02910	0.0	yuxL	3.4.19.1	-	EU	ko:K01303	-	ko00000,ko01000,ko01002	peptidase
HMBIOMIE_02911	2.57e-221	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HMBIOMIE_02912	2.4e-253	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMBIOMIE_02913	1.67e-307	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
HMBIOMIE_02914	4.63e-255	yutH	-	-	S	-	-	-	Spore coat protein
HMBIOMIE_02915	2.26e-101	yutG	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
HMBIOMIE_02916	3.69e-183	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HMBIOMIE_02917	2.38e-99	yutE	-	-	S	-	-	-	Protein of unknown function DUF86
HMBIOMIE_02918	3.2e-63	yutD	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_02919	9.45e-145	yutC	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
HMBIOMIE_02920	1.37e-215	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMBIOMIE_02921	2.66e-252	lytH	-	-	M	ko:K21472	-	ko00000,ko01000,ko01002,ko01011	Peptidase, M23
HMBIOMIE_02922	4.25e-172	yunB	-	-	S	-	-	-	Sporulation protein YunB (Spo_YunB)
HMBIOMIE_02923	1.39e-64	yunC	-	-	S	-	-	-	Domain of unknown function (DUF1805)
HMBIOMIE_02924	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HMBIOMIE_02925	6.51e-181	yunE	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HMBIOMIE_02926	4.26e-220	yunF	-	-	S	-	-	-	Protein of unknown function DUF72
HMBIOMIE_02927	1.07e-79	yunG	-	-	-	-	-	-	-
HMBIOMIE_02928	0.0	allB	3.5.2.5	-	F	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
HMBIOMIE_02929	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
HMBIOMIE_02930	3.65e-292	pbuX	-	-	F	ko:K03458,ko:K16169,ko:K16170	-	ko00000,ko02000	Permease family
HMBIOMIE_02931	7.82e-284	pbuX	-	-	F	ko:K16169,ko:K16170	-	ko00000,ko02000	xanthine
HMBIOMIE_02932	0.0	-	1.7.3.3, 4.1.1.97	-	Q	ko:K16838	ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
HMBIOMIE_02933	2.09e-72	pucM	3.5.2.17	-	S	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
HMBIOMIE_02934	2.42e-122	-	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03518	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
HMBIOMIE_02935	0.0	pucD	1.17.1.4	-	C	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
HMBIOMIE_02936	4.85e-194	pucC	1.17.1.4, 1.2.5.3	-	C	ko:K00087,ko:K03519	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
HMBIOMIE_02937	2.62e-144	pucB	1.17.1.4, 2.7.7.76	-	S	ko:K00087,ko:K07141	ko00230,ko00790,ko01100,ko01120,map00230,map00790,map01100,map01120	ko00000,ko00001,ko00002,ko01000	MobA-like NTP transferase domain
HMBIOMIE_02938	5.12e-243	pucA	1.17.1.4	-	O	ko:K00087,ko:K07402	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HMBIOMIE_02940	8.51e-306	pucG	2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51	-	E	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	ko00000,ko00001,ko00002,ko01000,ko01007	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
HMBIOMIE_02941	4.9e-303	pucF	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
HMBIOMIE_02942	6.53e-218	bsn	-	-	L	-	-	-	Ribonuclease
HMBIOMIE_02943	2.95e-263	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_02944	7.46e-176	frlR1	-	-	K	ko:K03710,ko:K10711	-	ko00000,ko03000	UTRA
HMBIOMIE_02945	9.57e-209	-	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
HMBIOMIE_02946	1.94e-216	-	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
HMBIOMIE_02947	1.24e-199	yurN	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HMBIOMIE_02948	2.46e-308	yurO	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1653 ABC-type sugar transport system, periplasmic component
HMBIOMIE_02949	2.24e-236	frlB	-	-	M	ko:K10708	-	ko00000,ko01000	Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
HMBIOMIE_02950	1.2e-87	yurQ	-	-	L	-	-	-	COG0322 Nuclease subunit of the excinuclease complex
HMBIOMIE_02951	1.42e-268	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
HMBIOMIE_02953	3.35e-56	-	-	-	-	-	-	-	-
HMBIOMIE_02954	2.14e-87	yurT	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_02955	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	FeS cluster assembly
HMBIOMIE_02956	6.26e-101	nifU	-	-	C	ko:K04488	-	ko00000	COG0822 NifU homolog involved in Fe-S cluster formation
HMBIOMIE_02957	2.81e-299	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMBIOMIE_02958	7.43e-313	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
HMBIOMIE_02959	3.82e-183	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
HMBIOMIE_02960	5.44e-81	yurZ	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMBIOMIE_02961	1.01e-189	metQ	-	-	P	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
HMBIOMIE_02962	6.5e-126	metI	-	-	P	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
HMBIOMIE_02963	2.15e-236	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMBIOMIE_02964	1.53e-74	yusD	-	-	S	-	-	-	SCP-2 sterol transfer family
HMBIOMIE_02965	2e-73	yusE	-	-	CO	-	-	-	Thioredoxin
HMBIOMIE_02966	1.32e-97	yusF	-	-	L	ko:K07476	-	ko00000	COG1658 Small primase-like proteins (Toprim domain)
HMBIOMIE_02967	7.34e-54	yusG	-	-	S	-	-	-	Protein of unknown function (DUF2553)
HMBIOMIE_02968	5.91e-85	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
HMBIOMIE_02969	1.01e-83	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
HMBIOMIE_02970	0.0	fadE	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
HMBIOMIE_02971	1.34e-278	fadA	2.3.1.16	-	I	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the thiolase family
HMBIOMIE_02972	0.0	fadN	1.1.1.35	-	I	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	ko00000,ko00001,ko00002,ko01000	3-hydroxyacyl-CoA dehydrogenase
HMBIOMIE_02973	2.86e-14	-	-	-	S	-	-	-	YuzL-like protein
HMBIOMIE_02974	2.09e-212	fadM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
HMBIOMIE_02975	2.23e-54	-	-	-	-	-	-	-	-
HMBIOMIE_02976	2.12e-70	yusN	-	-	M	-	-	-	Coat F domain
HMBIOMIE_02977	3.15e-98	yusO	-	-	K	-	-	-	Iron dependent repressor, N-terminal DNA binding domain
HMBIOMIE_02978	0.0	yusP	-	-	P	-	-	-	Major facilitator superfamily
HMBIOMIE_02979	1.7e-84	yusQ	-	-	S	-	-	-	Tautomerase enzyme
HMBIOMIE_02980	4.97e-138	yusR	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_02981	3.43e-203	gltR	-	-	K	ko:K21959	-	ko00000,ko03000	LysR substrate binding domain
HMBIOMIE_02982	3.99e-53	yusU	-	-	S	-	-	-	Protein of unknown function (DUF2573)
HMBIOMIE_02983	4.33e-196	yusV	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HMBIOMIE_02984	3.48e-88	-	-	-	S	-	-	-	YusW-like protein
HMBIOMIE_02985	0.0	pepF2	-	-	E	-	-	-	COG1164 Oligoendopeptidase F
HMBIOMIE_02986	1.91e-197	yusZ	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_02987	1.07e-104	fri	-	-	P	ko:K04047	-	ko00000,ko03036	Ferritin-like domain
HMBIOMIE_02988	9.63e-306	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMBIOMIE_02989	2.23e-164	cssR	-	-	T	ko:K07770	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_02990	0.0	cssS	2.7.13.3	-	T	ko:K07650	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_02991	3.06e-204	yuxN	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_02992	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HMBIOMIE_02993	2.6e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF3970)
HMBIOMIE_02994	0.0	gerAA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
HMBIOMIE_02995	4.6e-250	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
HMBIOMIE_02996	2.01e-248	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
HMBIOMIE_02997	9.39e-141	vraR	-	-	KT	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_02998	1.16e-245	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_02999	7.65e-164	-	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
HMBIOMIE_03000	2.48e-166	liaG	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
HMBIOMIE_03001	2.44e-143	liaH	-	-	KT	ko:K03969,ko:K11620	ko02020,map02020	ko00000,ko00001,ko00002	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
HMBIOMIE_03002	1.51e-82	liaI	-	-	S	ko:K11619	ko02020,map02020	ko00000,ko00001,ko00002	membrane
HMBIOMIE_03003	9.24e-288	yvqJ	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_03004	1.2e-129	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Adenosyltransferase
HMBIOMIE_03005	7.08e-307	yvrA	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
HMBIOMIE_03006	1.56e-235	btuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_03007	2.98e-218	btuF	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
HMBIOMIE_03008	1.23e-180	yvrD	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_03009	1.32e-219	yvrE	-	-	G	ko:K14274	ko00040,map00040	ko00000,ko00001,ko01000	SMP-30/Gluconolaconase/LRE-like region
HMBIOMIE_03010	0.0	yvrG	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_03011	1.1e-170	yvrH	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_03012	5.07e-32	-	-	-	-	-	-	-	-
HMBIOMIE_03013	6.74e-126	yvrI	-	-	K	ko:K03093	-	ko00000,ko03021	RNA polymerase
HMBIOMIE_03014	3.46e-26	-	-	-	S	-	-	-	YvrJ protein family
HMBIOMIE_03015	4.39e-290	oxdC	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
HMBIOMIE_03016	8.13e-85	yvrL	-	-	S	-	-	-	Regulatory protein YrvL
HMBIOMIE_03017	2.21e-272	yvrN	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
HMBIOMIE_03018	3.82e-158	yvrO	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_03019	3.61e-231	-	-	-	M	ko:K02005	-	ko00000	Efflux transporter rnd family, mfp subunit
HMBIOMIE_03020	2.92e-191	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HMBIOMIE_03021	3.76e-223	fhuG	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_03022	1.48e-237	fhuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMBIOMIE_03023	1.14e-227	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_03025	0.0	yvsH	-	-	E	ko:K03294,ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
HMBIOMIE_03026	9.37e-23	-	-	-	S	ko:K06427	-	ko00000	Small spore protein J (Spore_SspJ)
HMBIOMIE_03027	2.38e-109	yvsG	-	-	S	ko:K07038	-	ko00000	LexA-binding, inner membrane-associated putative hydrolase
HMBIOMIE_03028	0.0	yvgJ	-	-	M	ko:K01138	-	ko00000,ko01000	Belongs to the LTA synthase family
HMBIOMIE_03029	5.58e-218	yvgK	-	-	P	ko:K07219	-	ko00000	COG1910 Periplasmic molybdate-binding protein domain
HMBIOMIE_03030	6.57e-179	modA	-	-	P	ko:K02020	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0725 ABC-type molybdate transport system, periplasmic component
HMBIOMIE_03031	6.08e-154	modB	-	-	P	ko:K02018	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4149 ABC-type molybdate transport system, permease component
HMBIOMIE_03032	4.54e-203	yvgN	-	-	S	-	-	-	reductase
HMBIOMIE_03033	7.97e-113	yvgO	-	-	-	-	-	-	-
HMBIOMIE_03034	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	COG0025 NhaP-type Na H and K H antiporters
HMBIOMIE_03035	0.0	cysI	1.8.1.2, 1.8.7.1	-	P	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
HMBIOMIE_03036	0.0	cysJ	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HMBIOMIE_03037	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HMBIOMIE_03038	3.88e-140	yvgT	-	-	S	-	-	-	membrane
HMBIOMIE_03039	1.99e-95	bdbC	-	-	O	ko:K03611	-	ko00000,ko03110	Required for disulfide bond formation in some proteins
HMBIOMIE_03040	3.45e-137	bdbD	-	-	O	-	-	-	Thioredoxin
HMBIOMIE_03041	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
HMBIOMIE_03042	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
HMBIOMIE_03043	3.66e-41	copZ	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	Copper resistance protein CopZ
HMBIOMIE_03044	6.89e-65	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	transcriptional
HMBIOMIE_03045	7.89e-254	yvaA	1.1.1.371	-	S	ko:K16044	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
HMBIOMIE_03046	3.59e-154	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HMBIOMIE_03047	0.0	-	-	-	S	-	-	-	Fusaric acid resistance protein-like
HMBIOMIE_03048	2.02e-97	yvaD	-	-	S	-	-	-	Family of unknown function (DUF5360)
HMBIOMIE_03049	4.28e-72	yvaE	-	-	P	ko:K03297	-	ko00000,ko02000	Small Multidrug Resistance protein
HMBIOMIE_03050	8.9e-131	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HMBIOMIE_03051	1.61e-181	yvaG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_03053	2.4e-107	smpB	-	-	O	ko:K03664	-	ko00000	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMBIOMIE_03054	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HMBIOMIE_03055	3.43e-183	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Carboxylesterase
HMBIOMIE_03056	1.87e-35	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
HMBIOMIE_03057	4.03e-196	yvaM	1.11.1.10	-	S	ko:K00433	-	ko00000,ko01000	Serine aminopeptidase, S33
HMBIOMIE_03058	3.44e-48	yvzC	-	-	K	-	-	-	transcriptional
HMBIOMIE_03059	4.08e-92	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	transcriptional
HMBIOMIE_03060	1.19e-92	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	Cro/C1-type HTH DNA-binding domain
HMBIOMIE_03061	3.85e-72	yvaP	-	-	K	-	-	-	transcriptional
HMBIOMIE_03062	0.0	yvaQ	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
HMBIOMIE_03063	2.26e-144	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
HMBIOMIE_03064	2.89e-221	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HMBIOMIE_03065	1.55e-142	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
HMBIOMIE_03066	6.29e-272	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HMBIOMIE_03067	1.15e-122	yvbF	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
HMBIOMIE_03068	2.75e-11	-	-	-	S	-	-	-	Sporulation delaying protein SdpA
HMBIOMIE_03069	4.79e-224	-	-	-	-	-	-	-	-
HMBIOMIE_03071	8.32e-133	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
HMBIOMIE_03072	9.63e-60	sdpR	-	-	K	-	-	-	transcriptional
HMBIOMIE_03073	1.21e-145	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
HMBIOMIE_03074	2.58e-223	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HMBIOMIE_03075	5.63e-145	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
HMBIOMIE_03076	5.58e-270	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
HMBIOMIE_03077	1.74e-130	yvbF	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
HMBIOMIE_03078	9.68e-136	yvbG	-	-	U	ko:K05595	-	ko00000,ko02000	UPF0056 membrane protein
HMBIOMIE_03079	1.03e-145	yvbH	-	-	S	-	-	-	YvbH-like oligomerisation region
HMBIOMIE_03080	1.38e-157	yvbI	-	-	M	-	-	-	Membrane
HMBIOMIE_03081	0.0	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
HMBIOMIE_03082	2.4e-106	yvbK	-	-	K	-	-	-	acetyltransferase
HMBIOMIE_03083	1.38e-309	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HMBIOMIE_03084	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of 2-phosphoglycerate and
HMBIOMIE_03085	2.12e-176	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HMBIOMIE_03086	1.97e-277	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
HMBIOMIE_03087	5.72e-238	gapA	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HMBIOMIE_03088	2.42e-237	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HMBIOMIE_03089	0.0	araE	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_03090	1.51e-258	araR	-	-	K	ko:K02103	-	ko00000,ko03000	transcriptional
HMBIOMIE_03091	1.04e-245	yvbT	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_03092	3.45e-206	yvbU	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03093	2.37e-199	yvbV	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_03094	7.07e-307	yvbW	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_03095	2.68e-252	-	-	-	S	-	-	-	Glycosyl hydrolase
HMBIOMIE_03096	1.45e-172	lutC	-	-	S	ko:K00782	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HMBIOMIE_03097	0.0	lutB	-	-	C	ko:K18929	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
HMBIOMIE_03098	5.47e-176	lutA	-	-	C	ko:K18928	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
HMBIOMIE_03099	7.53e-137	desR	-	-	T	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_03100	1.76e-257	yvfT	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_03101	2.48e-171	XK27_09830	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
HMBIOMIE_03102	1.03e-209	yvfR	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
HMBIOMIE_03103	7.25e-201	rsbQ	-	-	S	ko:K19707	-	ko00000,ko03021	Alpha/beta hydrolase family
HMBIOMIE_03104	1.52e-265	-	3.1.3.3	-	T	ko:K07315	-	ko00000,ko01000,ko03021	response regulator
HMBIOMIE_03105	0.0	ganB	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
HMBIOMIE_03106	0.0	lacA	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	beta-galactosidase
HMBIOMIE_03107	3.82e-194	malG	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
HMBIOMIE_03108	1.3e-301	malC	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
HMBIOMIE_03109	2.05e-295	cycB	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
HMBIOMIE_03110	6.42e-237	lacR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_03111	6.85e-146	yvfI	-	-	K	ko:K05799	-	ko00000,ko03000	COG2186 Transcriptional regulators
HMBIOMIE_03112	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
HMBIOMIE_03113	2.57e-308	rpoN	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
HMBIOMIE_03114	5.69e-44	yvfG	-	-	S	-	-	-	YvfG protein
HMBIOMIE_03115	1.85e-241	epsO	-	-	GM	ko:K19431	-	ko00000,ko01000	Exopolysaccharide biosynthesis protein
HMBIOMIE_03116	1.2e-284	epsN	-	-	E	ko:K19430	-	ko00000,ko01000	Belongs to the DegT DnrJ EryC1 family
HMBIOMIE_03117	6.53e-81	epsM	-	-	GM	ko:K19429	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
HMBIOMIE_03118	1.65e-141	epsL	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HMBIOMIE_03119	0.0	epsK	-	-	S	ko:K19418	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_03120	4.44e-251	epsJ	-	GT2	S	ko:K19427	-	ko00000,ko01000	COG0463 Glycosyltransferases involved in cell wall biogenesis
HMBIOMIE_03121	5.09e-264	epsI	-	-	GM	ko:K19426	-	ko00000,ko01000	pyruvyl transferase
HMBIOMIE_03122	6.3e-251	epsH	-	GT2	S	ko:K19425	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
HMBIOMIE_03123	8.82e-265	epsG	-	-	S	ko:K19419	-	ko00000,ko02000	EpsG family
HMBIOMIE_03124	7.49e-280	epsF	-	GT4	M	ko:K19424	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HMBIOMIE_03125	2.16e-202	epsE	-	GT2	M	ko:K19423	-	ko00000,ko01000,ko01003	COG0463 Glycosyltransferases involved in cell wall biogenesis
HMBIOMIE_03126	2.95e-286	epsD	-	GT4	M	ko:K19422	-	ko00000,ko01000	Glycosyl transferase 4-like
HMBIOMIE_03127	0.0	capD	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
HMBIOMIE_03128	7.94e-150	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
HMBIOMIE_03129	2.78e-158	epsA	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
HMBIOMIE_03130	4.34e-99	-	-	-	K	ko:K19417	-	ko00000,ko03000	transcriptional
HMBIOMIE_03131	0.0	pnbA	-	CE10	I	ko:K03929	-	ko00000,ko01000	Belongs to the type-B carboxylesterase lipase family
HMBIOMIE_03133	5.4e-120	padC	-	-	Q	ko:K13727	-	ko00000,ko01000	Phenolic acid decarboxylase
HMBIOMIE_03134	5.1e-64	-	-	-	S	-	-	-	Protein of unknown function (DUF3237)
HMBIOMIE_03135	1.51e-163	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
HMBIOMIE_03136	0.0	pbpE	-	-	V	-	-	-	Beta-lactamase
HMBIOMIE_03137	0.0	sacB	2.4.1.10, 2.4.1.9	GH68	M	ko:K00692,ko:K20811	ko00500,ko01100,ko02020,map00500,map01100,map02020	ko00000,ko00001,ko01000,ko01003	levansucrase activity
HMBIOMIE_03138	0.0	sacC3	3.2.1.65	GH32	G	ko:K01212	ko00500,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
HMBIOMIE_03139	0.0	ybeC	-	-	E	-	-	-	amino acid
HMBIOMIE_03140	1.17e-137	yvdT_1	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03141	6.31e-68	yvdS	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
HMBIOMIE_03142	1.03e-66	yvdR	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
HMBIOMIE_03143	5.53e-122	yvdQ	-	-	S	-	-	-	Protein of unknown function (DUF3231)
HMBIOMIE_03144	0.0	yvdP	-	-	C	-	-	-	COG0277 FAD FMN-containing dehydrogenases
HMBIOMIE_03145	1.99e-235	-	-	-	S	-	-	-	Patatin-like phospholipase
HMBIOMIE_03147	8.17e-135	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HMBIOMIE_03148	1.01e-156	pgmB	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HMBIOMIE_03149	0.0	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
HMBIOMIE_03150	0.0	yvdK	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Glycoside hydrolase, family 65
HMBIOMIE_03151	1.38e-197	malA	-	-	S	-	-	-	Protein of unknown function (DUF1189)
HMBIOMIE_03152	9.72e-190	malD	-	-	P	ko:K15772	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport
HMBIOMIE_03153	1.01e-309	malC	-	-	P	ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1175 ABC-type sugar transport systems, permease components
HMBIOMIE_03154	1.63e-299	mdxE	-	-	G	ko:K02027,ko:K15770,ko:K17237	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2182 Maltose-binding periplasmic proteins domains
HMBIOMIE_03155	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, N-terminal ig-like domain
HMBIOMIE_03156	2.28e-223	yvdE	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03157	2.66e-137	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
HMBIOMIE_03158	4.54e-70	yvdC	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
HMBIOMIE_03159	0.0	yvdB	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
HMBIOMIE_03160	3.73e-137	yvdA	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
HMBIOMIE_03161	1.4e-235	yvcT	1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81	-	CH	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMBIOMIE_03162	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
HMBIOMIE_03163	4.46e-181	yxdL_2	-	-	V	ko:K02003,ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_03164	1.68e-252	yvcQ	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
HMBIOMIE_03165	4.67e-172	yvcP	-	-	T	ko:K02483,ko:K11634	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_03166	1.37e-45	-	-	-	-	-	-	-	-
HMBIOMIE_03167	5.24e-188	yvcN	2.3.1.118	-	Q	ko:K00675	-	ko00000,ko01000	Belongs to the arylamine N-acetyltransferase family
HMBIOMIE_03168	3.92e-50	crh	-	-	G	ko:K11184	-	ko00000	Phosphocarrier protein Chr
HMBIOMIE_03169	3.63e-220	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
HMBIOMIE_03170	6.72e-227	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
HMBIOMIE_03171	2.09e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
HMBIOMIE_03172	2.39e-117	yvcI	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
HMBIOMIE_03173	8.31e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HMBIOMIE_03174	3.05e-190	spl	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	protein conserved in bacteria
HMBIOMIE_03175	0.0	yvcD	-	-	S	-	-	-	COG0457 FOG TPR repeat
HMBIOMIE_03176	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
HMBIOMIE_03178	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_03179	6.36e-172	-	-	-	-	-	-	-	-
HMBIOMIE_03180	2.61e-146	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the PRA-CH family
HMBIOMIE_03181	9.74e-177	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HMBIOMIE_03182	1.44e-170	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMBIOMIE_03183	7.21e-150	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMBIOMIE_03184	4.96e-139	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
HMBIOMIE_03185	1.19e-297	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMBIOMIE_03186	9.09e-149	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HMBIOMIE_03187	2.07e-282	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HMBIOMIE_03188	2.14e-179	yvpB	-	-	NU	-	-	-	protein conserved in bacteria
HMBIOMIE_03189	5.68e-156	-	4.2.2.10, 4.2.2.2	-	G	ko:K19551	ko00040,map00040	ko00000,ko00001,ko01000	Pectate lyase
HMBIOMIE_03190	5.29e-121	yvoF	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
HMBIOMIE_03191	3.05e-153	ppaX	3.6.1.1	-	S	ko:K06019	ko00190,map00190	ko00000,ko00001,ko01000	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
HMBIOMIE_03192	3.56e-209	yvoD	-	-	P	-	-	-	COG0370 Fe2 transport system protein B
HMBIOMIE_03193	3.18e-195	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMBIOMIE_03194	3.62e-217	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMBIOMIE_03195	2.25e-284	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HMBIOMIE_03196	1.39e-171	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HMBIOMIE_03197	5.23e-172	yvoA	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
HMBIOMIE_03198	0.0	yvnB	-	-	Q	-	-	-	Calcineurin-like phosphoesterase
HMBIOMIE_03199	9.4e-110	yvnA	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_03200	1.61e-293	cypX	1.14.14.46, 1.14.15.13	-	C	ko:K15468,ko:K16593,ko:K17474	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
HMBIOMIE_03201	2.49e-177	yvmC	2.3.2.22	-	S	ko:K17485	-	ko00000,ko01000	Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L- phenylalanine, L-leucine and methionine, into cyclodipeptides
HMBIOMIE_03202	6.2e-114	yvmB	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_03203	4.26e-272	yvmA	-	-	EGP	-	-	-	Major Facilitator Superfamily
HMBIOMIE_03204	3.8e-66	yvlD	-	-	S	ko:K08972	-	ko00000	Membrane
HMBIOMIE_03205	1.5e-36	yvlC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain
HMBIOMIE_03206	5.8e-221	yvlB	-	-	S	-	-	-	Putative adhesin
HMBIOMIE_03207	8.09e-65	yvlA	-	-	-	-	-	-	-
HMBIOMIE_03208	2.73e-46	yvkN	-	-	-	-	-	-	-
HMBIOMIE_03209	2.57e-104	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMBIOMIE_03210	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HMBIOMIE_03211	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HMBIOMIE_03212	2.54e-42	csbA	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03213	0.0	yvkC	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphotransferase
HMBIOMIE_03214	1.43e-131	yvkB	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03215	5.47e-298	yvkA	-	-	P	-	-	-	-transporter
HMBIOMIE_03216	5.48e-281	minJ	-	-	O	-	-	-	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMBIOMIE_03217	1.38e-73	swrA	-	-	S	-	-	-	Swarming motility protein
HMBIOMIE_03218	0.0	ctpB	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
HMBIOMIE_03219	1.1e-198	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
HMBIOMIE_03220	1.5e-159	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
HMBIOMIE_03221	3.23e-75	cccB	-	-	C	ko:K12263,ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
HMBIOMIE_03222	6.5e-185	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
HMBIOMIE_03223	2e-232	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMBIOMIE_03224	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HMBIOMIE_03225	1.73e-132	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMBIOMIE_03226	9.14e-88	-	-	-	-	-	-	-	-
HMBIOMIE_03227	8.69e-09	fliT	-	-	S	ko:K02423	ko02040,map02040	ko00000,ko00001,ko02035	bacterial-type flagellum organization
HMBIOMIE_03228	5.15e-91	fliS	-	-	N	ko:K02422	ko02040,map02040	ko00000,ko00001,ko02035	flagellar protein FliS
HMBIOMIE_03229	0.0	fliD	-	-	N	ko:K02407	ko02040,map02040	ko00000,ko00001,ko02035	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HMBIOMIE_03230	1.1e-76	flaG	-	-	N	ko:K06603	-	ko00000,ko02035	flagellar protein FlaG
HMBIOMIE_03231	8.01e-202	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMBIOMIE_03232	2.58e-41	csrA	-	-	T	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	ko00000,ko00001,ko03019	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HMBIOMIE_03233	1.23e-96	fliW	-	-	S	ko:K13626	-	ko00000,ko02035	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HMBIOMIE_03234	4.19e-93	yviE	-	-	-	-	-	-	-
HMBIOMIE_03235	1.97e-199	flgL	-	-	N	ko:K02397	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the bacterial flagellin family
HMBIOMIE_03236	0.0	flgK	-	-	N	ko:K02396	ko02040,map02040	ko00000,ko00001,ko02035	flagellar hook-associated protein
HMBIOMIE_03237	3.5e-102	yvyG	-	-	NOU	-	-	-	FlgN protein
HMBIOMIE_03238	1.06e-53	flgM	-	-	KNU	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	ko00000,ko00001,ko02035	Negative regulator of flagellin synthesis
HMBIOMIE_03239	1.83e-96	yvyF	-	-	S	-	-	-	flagellar protein
HMBIOMIE_03240	9.99e-166	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Phosphoribosyl transferase domain
HMBIOMIE_03241	1.26e-61	comFB	-	-	S	ko:K02241	-	ko00000,ko00002,ko02044	Late competence development protein ComFB
HMBIOMIE_03242	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMBIOMIE_03243	2.15e-199	degV	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03244	7.16e-163	degU	-	-	KT	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_03245	2.94e-247	degS	2.7.13.3	-	T	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
HMBIOMIE_03246	2.41e-155	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
HMBIOMIE_03247	5.04e-225	yvhJ	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03248	2.1e-231	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
HMBIOMIE_03249	4.13e-297	tuaH	-	-	M	ko:K16699	-	ko00000,ko01000,ko01003	Teichuronic acid biosynthesis glycosyltransferase tuaH
HMBIOMIE_03250	1.2e-186	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
HMBIOMIE_03251	2.26e-144	tuaF	-	-	M	ko:K16706	-	ko00000	protein involved in exopolysaccharide biosynthesis
HMBIOMIE_03252	0.0	tuaE	-	-	M	ko:K16705	-	ko00000	Teichuronic acid biosynthesis protein
HMBIOMIE_03253	0.0	tuaD	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMBIOMIE_03254	6.91e-280	tuaC	-	GT4	GM	ko:K16697	-	ko00000,ko01000,ko01003	Teichuronic acid
HMBIOMIE_03255	3.44e-316	tuaB	-	-	S	ko:K03328,ko:K16694,ko:K16695	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_03256	1.49e-143	tuaA	-	-	M	-	-	-	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
HMBIOMIE_03257	0.0	lytC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
HMBIOMIE_03258	0.0	lytB	-	-	D	-	-	-	Stage II sporulation protein
HMBIOMIE_03259	3.26e-50	-	-	-	-	-	-	-	-
HMBIOMIE_03260	2.77e-219	lytR	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
HMBIOMIE_03261	1.01e-272	mnaA	5.1.3.14	-	M	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
HMBIOMIE_03262	1.78e-208	gtaB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HMBIOMIE_03263	0.0	-	-	-	M	-	-	-	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
HMBIOMIE_03264	0.0	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HMBIOMIE_03265	5.43e-05	-	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase-like
HMBIOMIE_03266	2.13e-127	gtaB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HMBIOMIE_03267	0.0	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
HMBIOMIE_03268	2.06e-194	tagG	-	-	GM	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
HMBIOMIE_03269	0.0	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMBIOMIE_03270	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferase 1 domain A
HMBIOMIE_03271	3.82e-91	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase
HMBIOMIE_03272	1.9e-185	tagA	2.4.1.187	GT26	M	ko:K05946	ko05111,map05111	ko00000,ko00001,ko01000,ko01003	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
HMBIOMIE_03273	3.8e-273	tagB	2.7.8.44	-	M	ko:K21285	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HMBIOMIE_03274	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_03275	0.0	lytD	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
HMBIOMIE_03276	1.16e-241	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HMBIOMIE_03277	0.0	gerBA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
HMBIOMIE_03278	1.24e-256	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
HMBIOMIE_03279	2.29e-275	gerBC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination protein
HMBIOMIE_03280	8.19e-316	ywtG	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_03281	1.48e-222	ywtF_2	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03282	7.24e-205	ywtE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
HMBIOMIE_03283	1.37e-304	pgdS	-	-	M	-	-	-	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
HMBIOMIE_03284	2.29e-29	ywtC	-	-	-	-	-	-	-
HMBIOMIE_03285	1.33e-277	capA	-	-	M	ko:K07282	-	ko00000	enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
HMBIOMIE_03286	8.44e-91	capC	-	-	S	ko:K22116	-	ko00000	biosynthesis protein
HMBIOMIE_03287	1.46e-283	capB	-	-	M	ko:K01932	-	ko00000,ko01000	COG0769 UDP-N-acetylmuramyl tripeptide synthase
HMBIOMIE_03288	2.3e-228	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
HMBIOMIE_03289	6.44e-207	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMBIOMIE_03290	5.6e-85	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HMBIOMIE_03291	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
HMBIOMIE_03292	2.87e-204	rbsC	-	-	G	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HMBIOMIE_03293	1.34e-205	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	COG1879 ABC-type sugar transport system, periplasmic component
HMBIOMIE_03294	2.49e-122	batE	-	-	T	-	-	-	Sh3 type 3 domain protein
HMBIOMIE_03295	9.2e-64	ywsA	-	-	S	-	-	-	Protein of unknown function (DUF3892)
HMBIOMIE_03296	2.15e-126	ywrO	-	-	S	-	-	-	NADPH-quinone reductase (modulator of drug activity B)
HMBIOMIE_03297	1.84e-187	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
HMBIOMIE_03298	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HMBIOMIE_03299	3.36e-218	alsR	-	-	K	-	-	-	LysR substrate binding domain
HMBIOMIE_03300	1.68e-281	ywrK	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMBIOMIE_03301	9.09e-164	ywrJ	-	-	-	-	-	-	-
HMBIOMIE_03302	1.02e-196	cotB	-	-	-	ko:K06325	-	ko00000	-
HMBIOMIE_03303	1.12e-269	cotH	-	-	M	ko:K06330	-	ko00000	Spore Coat
HMBIOMIE_03304	2.17e-16	-	-	-	-	-	-	-	-
HMBIOMIE_03305	4.35e-143	ywrF	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMBIOMIE_03306	2.78e-71	-	-	-	S	-	-	-	Domain of unknown function (DUF4181)
HMBIOMIE_03307	0.0	ywrD	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
HMBIOMIE_03308	4.83e-108	ywrC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
HMBIOMIE_03309	5.52e-133	ywrB	-	-	P	ko:K07240	-	ko00000,ko02000	Chromate transporter
HMBIOMIE_03310	3.66e-115	ywrA	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
HMBIOMIE_03312	5.03e-128	ywqN	-	-	S	-	-	-	NAD(P)H-dependent
HMBIOMIE_03313	2.34e-209	-	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03314	2.92e-148	nfi	3.1.21.7	-	L	ko:K05982	-	ko00000,ko01000,ko03400	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
HMBIOMIE_03316	1.44e-302	ywqJ	-	-	S	-	-	-	Pre-toxin TG
HMBIOMIE_03317	8.84e-52	ywqI	-	-	S	-	-	-	Family of unknown function (DUF5344)
HMBIOMIE_03319	7.24e-197	ywqG	-	-	S	-	-	-	Domain of unknown function (DUF1963)
HMBIOMIE_03320	9.82e-315	ywqF	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMBIOMIE_03321	3.16e-183	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	COG4464 Capsular polysaccharide biosynthesis protein
HMBIOMIE_03322	4.51e-156	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
HMBIOMIE_03323	5.33e-163	ywqC	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
HMBIOMIE_03324	3.6e-25	-	-	-	-	-	-	-	-
HMBIOMIE_03325	0.0	ywqB	-	-	S	-	-	-	SWIM zinc finger
HMBIOMIE_03326	0.0	ywqA	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
HMBIOMIE_03327	5.28e-202	ywpJ	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
HMBIOMIE_03328	4.82e-180	glcR	-	-	K	ko:K22103	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
HMBIOMIE_03329	1.04e-76	ssbB	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-stranded DNA-binding protein
HMBIOMIE_03330	5.26e-88	ywpG	-	-	-	-	-	-	-
HMBIOMIE_03331	8.81e-89	ywpF	-	-	S	-	-	-	YwpF-like protein
HMBIOMIE_03332	4.63e-68	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HMBIOMIE_03333	8.54e-198	ywpD	-	-	T	-	-	-	Histidine kinase
HMBIOMIE_03334	1.13e-79	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HMBIOMIE_03335	6.89e-107	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HMBIOMIE_03336	5.45e-257	rapD	-	-	S	ko:K06362	-	ko00000,ko01000	aspartate phosphatase
HMBIOMIE_03337	4.1e-182	flhP	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
HMBIOMIE_03338	6.18e-173	flhO	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
HMBIOMIE_03339	1.75e-231	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein
HMBIOMIE_03340	4.88e-59	spoIIID	-	-	K	ko:K06283	-	ko00000,ko03000	Stage III sporulation protein D
HMBIOMIE_03341	8.45e-92	-	-	-	K	-	-	-	COG1846 Transcriptional regulators
HMBIOMIE_03342	1.37e-269	ywoG	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_03343	1.02e-312	ywoF	-	-	P	-	-	-	Right handed beta helix region
HMBIOMIE_03344	0.0	-	-	-	FH	ko:K03457,ko:K10975	-	ko00000,ko02000	COG1953 Cytosine uracil thiamine allantoin permeases
HMBIOMIE_03345	8e-309	ywoD	-	-	EGP	-	-	-	Major facilitator superfamily
HMBIOMIE_03346	2.56e-134	yjgF	-	-	Q	-	-	-	Isochorismatase family
HMBIOMIE_03347	4.15e-100	-	-	-	-	-	-	-	-
HMBIOMIE_03348	1.6e-288	nrgA	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium transporter
HMBIOMIE_03349	4.51e-77	nrgB	-	-	K	ko:K04751	ko02020,map02020	ko00000,ko00001	Belongs to the P(II) protein family
HMBIOMIE_03350	6.02e-135	bcrC	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	COG0671 Membrane-associated phospholipid phosphatase
HMBIOMIE_03351	1.63e-95	ywnJ	-	-	S	-	-	-	VanZ like family
HMBIOMIE_03352	2.13e-175	spoIIQ	-	-	M	ko:K06386	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
HMBIOMIE_03353	1.55e-116	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	COG1247 Sortase and related acyltransferases
HMBIOMIE_03354	3.28e-22	ywnC	-	-	S	-	-	-	Family of unknown function (DUF5362)
HMBIOMIE_03355	7.07e-92	ywnF	-	-	S	-	-	-	Family of unknown function (DUF5392)
HMBIOMIE_03356	0.0	ywnE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMBIOMIE_03357	3.41e-184	mta	-	-	K	ko:K21743	-	ko00000,ko03000	transcriptional
HMBIOMIE_03358	1.06e-78	ywnC	-	-	S	-	-	-	Family of unknown function (DUF5362)
HMBIOMIE_03359	1.29e-148	ywnB	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
HMBIOMIE_03360	4.58e-85	ywnA	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03361	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
HMBIOMIE_03362	1.12e-83	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease beta subunit family
HMBIOMIE_03363	8.2e-68	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease gamma subunit family
HMBIOMIE_03364	1.11e-21	csbD	-	-	K	-	-	-	CsbD-like
HMBIOMIE_03365	1.12e-109	ywmF	-	-	S	-	-	-	Peptidase M50
HMBIOMIE_03366	1.25e-128	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
HMBIOMIE_03367	1.08e-245	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMBIOMIE_03368	2.22e-187	fdhD	-	-	C	ko:K02379	-	ko00000	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HMBIOMIE_03370	1.02e-155	ywmD	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
HMBIOMIE_03371	6.34e-156	ywmC	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
HMBIOMIE_03372	5.9e-235	spoIID	-	-	D	ko:K06381	-	ko00000	Stage II sporulation protein D
HMBIOMIE_03373	4.96e-306	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMBIOMIE_03374	2.68e-171	ywmB	-	-	S	-	-	-	TATA-box binding
HMBIOMIE_03375	4.54e-45	ywzB	-	-	S	-	-	-	membrane
HMBIOMIE_03376	8.36e-113	ywmA	-	-	-	-	-	-	-
HMBIOMIE_03377	2.44e-75	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
HMBIOMIE_03378	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMBIOMIE_03379	4.46e-195	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMBIOMIE_03380	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMBIOMIE_03381	7.94e-116	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMBIOMIE_03382	2.62e-79	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMBIOMIE_03383	3.01e-36	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMBIOMIE_03384	6.06e-167	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
HMBIOMIE_03385	1.91e-81	atpI	-	-	S	ko:K02116	-	ko00000,ko00194	ATP synthase
HMBIOMIE_03386	4.52e-147	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMBIOMIE_03387	4.36e-303	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMBIOMIE_03388	2.49e-123	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
HMBIOMIE_03389	2.35e-106	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase
HMBIOMIE_03390	1.58e-100	ywlE	3.1.3.48, 3.9.1.2	-	T	ko:K01104,ko:K20201	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMBIOMIE_03391	4.56e-117	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
HMBIOMIE_03392	7.37e-251	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HMBIOMIE_03393	1.79e-100	ywlB	-	-	E	-	-	-	Belongs to the acetyltransferase family. ArgA subfamily
HMBIOMIE_03394	1.14e-152	spoIIR	-	-	S	ko:K06387	-	ko00000	stage II sporulation protein R
HMBIOMIE_03395	9.69e-74	ywlA	-	-	S	-	-	-	Uncharacterised protein family (UPF0715)
HMBIOMIE_03397	5.96e-205	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HMBIOMIE_03398	9.95e-245	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMBIOMIE_03399	1.39e-88	ywkD	-	-	E	ko:K08234	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_03400	4.94e-116	racA	-	-	K	ko:K11686	-	ko00000,ko03036	Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
HMBIOMIE_03401	3.24e-204	ywkB	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
HMBIOMIE_03402	0.0	ykwA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
HMBIOMIE_03403	9.96e-135	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
HMBIOMIE_03404	7e-45	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the 23S rRNA
HMBIOMIE_03405	5.53e-303	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HMBIOMIE_03406	2.03e-224	glpX	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	fructose-1,6-bisphosphatase
HMBIOMIE_03407	2.26e-303	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMBIOMIE_03408	5.69e-147	tal	2.2.1.2	-	G	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMBIOMIE_03409	7.82e-204	fbaA	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Aldolase
HMBIOMIE_03410	1.07e-81	spo0F	-	-	T	ko:K02490	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG0784 FOG CheY-like receiver
HMBIOMIE_03411	3.31e-120	ywjG	-	-	S	-	-	-	Domain of unknown function (DUF2529)
HMBIOMIE_03412	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HMBIOMIE_03413	1.03e-82	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HMBIOMIE_03414	2.1e-269	acdA	-	-	I	-	-	-	acyl-CoA dehydrogenase
HMBIOMIE_03415	0.0	ywjF	-	-	C	-	-	-	COG0247 Fe-S oxidoreductase
HMBIOMIE_03416	8.56e-290	clsB	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the phospholipase D family. Cardiolipin synthase subfamily
HMBIOMIE_03417	4.88e-236	uvsE	-	-	L	ko:K13281	-	ko00000,ko01000	Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
HMBIOMIE_03418	1.32e-57	ywjC	-	-	-	-	-	-	-
HMBIOMIE_03419	1.35e-124	ywjB	-	-	H	-	-	-	RibD C-terminal domain
HMBIOMIE_03420	0.0	ywjA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HMBIOMIE_03421	0.0	ywiE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMBIOMIE_03422	2.06e-159	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase (gamma
HMBIOMIE_03423	2.28e-121	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	nitrate reductase
HMBIOMIE_03424	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase, beta
HMBIOMIE_03425	0.0	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMBIOMIE_03426	8.67e-111	arfM	-	-	T	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	cyclic nucleotide binding
HMBIOMIE_03427	1.84e-179	ywiC	-	-	S	-	-	-	YwiC-like protein
HMBIOMIE_03428	3.98e-169	fnr	-	-	K	-	-	-	helix_turn_helix, cAMP Regulatory protein
HMBIOMIE_03429	3.39e-274	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
HMBIOMIE_03430	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
HMBIOMIE_03431	4.64e-96	ywiB	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03432	3.71e-12	-	-	-	S	-	-	-	Bacteriocin subtilosin A
HMBIOMIE_03433	0.0	-	-	-	C	ko:K22227	-	ko00000	Fe-S oxidoreductases
HMBIOMIE_03435	1.5e-169	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HMBIOMIE_03436	6.61e-295	mgtA	3.6.3.2	-	P	ko:K01531,ko:K16905	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMBIOMIE_03437	3.29e-274	-	2.7.1.26, 2.7.7.2	-	L	ko:K07263,ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01002	Peptidase, M16
HMBIOMIE_03438	0.0	-	-	-	L	-	-	-	Peptidase, M16
HMBIOMIE_03440	0.0	ywhL	-	-	CO	-	-	-	amine dehydrogenase activity
HMBIOMIE_03441	1.82e-169	ywhK	-	-	CO	-	-	-	amine dehydrogenase activity
HMBIOMIE_03442	2.35e-82	ywhK	-	-	CO	-	-	-	amine dehydrogenase activity
HMBIOMIE_03443	2.88e-100	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
HMBIOMIE_03445	6.61e-110	-	-	-	S	-	-	-	Aminoacyl-tRNA editing domain
HMBIOMIE_03446	2.1e-215	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
HMBIOMIE_03447	1.93e-204	speE	2.5.1.16	-	E	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HMBIOMIE_03448	0.0	pbpG	2.4.1.129, 3.4.16.4	GT51	M	ko:K21464	ko00550,map00550	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HMBIOMIE_03449	2.24e-122	ywhD	-	-	S	-	-	-	YwhD family
HMBIOMIE_03450	3.29e-154	ywhC	-	-	S	-	-	-	Peptidase family M50
HMBIOMIE_03451	1.43e-35	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	4-oxalocrotonate tautomerase
HMBIOMIE_03452	1.45e-93	ywhA	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03453	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMBIOMIE_03455	2.66e-307	mmr	-	-	U	ko:K08166	-	ko00000,ko02000	Major Facilitator Superfamily
HMBIOMIE_03456	1.1e-103	yffB	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03457	1.47e-115	ywgA	-	-	-	ko:K09388	-	ko00000	-
HMBIOMIE_03458	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	COG1078 HD superfamily phosphohydrolases
HMBIOMIE_03459	8.55e-49	ywzC	-	-	S	-	-	-	Belongs to the UPF0741 family
HMBIOMIE_03460	5.39e-145	rsfA_1	-	-	-	ko:K06314	-	ko00000,ko03000	-
HMBIOMIE_03461	1.5e-200	ywfM	-	-	EG	ko:K03298	-	ko00000,ko02000	EamA-like transporter family
HMBIOMIE_03462	4.34e-199	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
HMBIOMIE_03463	3.73e-209	cysL	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_03464	6.8e-224	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	In Salmonella this enzyme is required for ethanolamine catabolism
HMBIOMIE_03465	3.43e-187	ywfI	-	-	C	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko01000	May function as heme-dependent peroxidase
HMBIOMIE_03466	2.37e-176	ywfH	-	-	IQ	ko:K19550	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_03467	1.74e-294	ywfG	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
HMBIOMIE_03468	1.85e-266	bacE	-	-	EGP	ko:K19552	-	ko00000,ko02000	Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic
HMBIOMIE_03469	0.0	bacD	6.3.2.49	-	F	ko:K13037	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
HMBIOMIE_03470	1.56e-178	bacC	1.1.1.385	-	IQ	ko:K19548	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
HMBIOMIE_03471	1.24e-175	bacB	5.3.3.19	-	S	ko:K19547	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
HMBIOMIE_03472	5.11e-146	bacA	4.1.1.100	-	E	ko:K19546	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
HMBIOMIE_03473	3.12e-274	ywfA	-	-	EGP	-	-	-	-transporter
HMBIOMIE_03474	0.0	rocC	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HMBIOMIE_03475	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
HMBIOMIE_03476	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
HMBIOMIE_03477	5.19e-311	rocG	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
HMBIOMIE_03478	1.1e-102	-	-	-	-	-	-	-	-
HMBIOMIE_03479	9.16e-114	spsL	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Spore Coat
HMBIOMIE_03480	2.44e-206	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HMBIOMIE_03481	7.47e-233	spsJ	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HMBIOMIE_03482	3.04e-177	spsI	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMBIOMIE_03483	2.84e-240	spsG	-	-	M	-	-	-	Spore Coat
HMBIOMIE_03484	4.64e-169	spsF	-	-	M	ko:K07257	-	ko00000	Spore Coat
HMBIOMIE_03485	7.93e-271	pseI	2.5.1.56, 2.5.1.97	-	M	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	acid synthase
HMBIOMIE_03486	1.16e-207	spsD	2.3.1.210	-	K	ko:K16704	-	ko00000,ko01000	Spore Coat
HMBIOMIE_03487	3.73e-284	spsC	2.6.1.102	-	E	ko:K13010	ko00520,map00520	ko00000,ko00001,ko01000,ko01005,ko01007	Belongs to the DegT DnrJ EryC1 family
HMBIOMIE_03488	0.0	spsB	-	-	M	-	-	-	Capsule polysaccharide biosynthesis protein
HMBIOMIE_03489	2.71e-185	spsA	-	-	M	-	-	-	Spore Coat
HMBIOMIE_03490	7.61e-114	gerQ	-	-	S	ko:K06305	-	ko00000	Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
HMBIOMIE_03491	1.59e-78	ywdK	-	-	S	-	-	-	small membrane protein
HMBIOMIE_03492	1.86e-303	ywdJ	-	-	F	-	-	-	Xanthine uracil
HMBIOMIE_03493	2.18e-63	ywdI	-	-	S	-	-	-	Family of unknown function (DUF5327)
HMBIOMIE_03494	0.0	ywdH	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HMBIOMIE_03495	2.32e-166	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMBIOMIE_03496	1.57e-190	ywdF	-	-	S	-	-	-	Glycosyltransferase like family 2
HMBIOMIE_03497	5.43e-188	pdxK	2.7.1.35, 2.7.1.49, 2.7.4.7	-	H	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HMBIOMIE_03498	6.19e-39	ywdA	-	-	-	-	-	-	-
HMBIOMIE_03499	0.0	sacA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
HMBIOMIE_03500	0.0	sacP	2.7.1.211	-	G	ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_03501	2.91e-180	-	-	-	P	ko:K02598	-	ko00000,ko02000	Formate/nitrite transporter
HMBIOMIE_03502	1.29e-193	sacT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
HMBIOMIE_03504	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_03505	4.19e-239	ywcH	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_03506	1.98e-179	nfrA1	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	Oxidoreductase
HMBIOMIE_03507	8.89e-269	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
HMBIOMIE_03508	6.61e-52	ywcE	-	-	S	-	-	-	Required for proper spore morphogenesis. Important for spore germination
HMBIOMIE_03509	1.12e-83	qoxD	1.10.3.12	-	C	ko:K02829	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
HMBIOMIE_03510	1.2e-144	qoxC	1.10.3.12	-	C	ko:K02828	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
HMBIOMIE_03511	0.0	qoxB	1.10.3.12	-	C	ko:K02827	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMBIOMIE_03512	6.94e-226	qoxA	1.10.3.12	-	C	ko:K02826	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
HMBIOMIE_03513	5.11e-49	ydaS	-	-	S	-	-	-	membrane
HMBIOMIE_03514	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
HMBIOMIE_03515	5.56e-291	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMBIOMIE_03516	3.33e-77	gtcA	-	-	S	-	-	-	GtrA-like protein
HMBIOMIE_03517	4.16e-159	ywcC	-	-	K	-	-	-	transcriptional regulator
HMBIOMIE_03519	1.23e-63	ywcB	-	-	S	-	-	-	Protein of unknown function, DUF485
HMBIOMIE_03520	0.0	ywcA	-	-	S	ko:K14393	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMBIOMIE_03521	1.08e-145	ywbO	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
HMBIOMIE_03522	3.23e-310	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Dyp-type peroxidase family protein
HMBIOMIE_03523	6.21e-249	ycdO	-	-	P	ko:K07224	-	ko00000,ko02000	periplasmic lipoprotein involved in iron transport
HMBIOMIE_03524	0.0	-	-	-	P	ko:K07243	-	ko00000,ko02000	COG0672 High-affinity Fe2 Pb2 permease
HMBIOMIE_03525	7.69e-150	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HMBIOMIE_03526	3.25e-185	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HMBIOMIE_03527	2.7e-203	ywbI	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03528	1.1e-76	ywbH	-	-	S	ko:K06518	-	ko00000,ko02000	Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
HMBIOMIE_03529	1.21e-143	ywbG	-	-	M	-	-	-	effector of murein hydrolase
HMBIOMIE_03530	2.49e-276	ywbF	-	-	EGP	ko:K05820	-	ko00000,ko02000	Nucleoside H+ symporter
HMBIOMIE_03531	3.13e-38	ywbE	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2196)
HMBIOMIE_03532	2.31e-279	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
HMBIOMIE_03533	4.01e-87	ywbC	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	glyoxalase
HMBIOMIE_03534	7.71e-122	-	-	-	N	-	-	-	domain, Protein
HMBIOMIE_03535	2.02e-80	ywbB	-	-	S	-	-	-	Protein of unknown function (DUF2711)
HMBIOMIE_03536	2.62e-56	ywbB	-	-	S	-	-	-	Protein of unknown function (DUF2711)
HMBIOMIE_03537	1.59e-315	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMBIOMIE_03538	5.03e-21	epr	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_03539	3.04e-308	epr	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HMBIOMIE_03540	2.79e-310	sacX	2.7.1.211	-	G	ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_03541	2.6e-195	sacT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
HMBIOMIE_03542	2.19e-215	gspA	-	-	M	-	-	-	General stress
HMBIOMIE_03543	1.22e-158	ywaF	-	-	S	-	-	-	Integral membrane protein
HMBIOMIE_03544	3.57e-114	ywaE	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03545	1.5e-295	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMBIOMIE_03546	0.0	ywaD	3.4.11.10, 3.4.11.6	-	S	ko:K19701	-	ko00000,ko01000,ko01002	PA domain
HMBIOMIE_03547	2.67e-116	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HMBIOMIE_03548	5.58e-64	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
HMBIOMIE_03549	3.96e-165	-	-	-	EGP	-	-	-	Permeases of the major facilitator superfamily
HMBIOMIE_03550	2.52e-149	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	protein conserved in bacteria
HMBIOMIE_03551	5.1e-213	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the MenA family. Type 1 subfamily
HMBIOMIE_03552	0.0	dltA	6.1.1.13	-	Q	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_03553	1.14e-297	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	membrane protein involved in D-alanine export
HMBIOMIE_03554	6.83e-50	dltC	6.1.1.13	-	IQ	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_03555	4.09e-294	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMBIOMIE_03556	2.91e-178	dltE	-	-	M	ko:K14189	-	ko00000,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_03557	1.07e-263	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
HMBIOMIE_03558	0.0	licH	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
HMBIOMIE_03559	1.58e-50	licA	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_03560	0.0	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMBIOMIE_03561	1.89e-67	licB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	transporter subunit IIB
HMBIOMIE_03562	0.0	licR	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HMBIOMIE_03563	8.94e-28	yxzF	-	-	-	-	-	-	-
HMBIOMIE_03564	3.23e-145	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
HMBIOMIE_03565	0.0	katX	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
HMBIOMIE_03566	2.27e-270	yxlH	-	-	EGP	-	-	-	Major Facilitator Superfamily
HMBIOMIE_03567	3.96e-179	yxlG	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HMBIOMIE_03568	2.09e-213	yxlF	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_03569	2.17e-39	yxlE	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
HMBIOMIE_03570	1.75e-43	-	-	-	-	-	-	-	-
HMBIOMIE_03571	4.05e-64	yxlC	-	-	S	-	-	-	Family of unknown function (DUF5345)
HMBIOMIE_03572	9.06e-125	sigY	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
HMBIOMIE_03573	0.0	yxlA	-	-	F	ko:K03457	-	ko00000	Belongs to the purine-cytosine permease (2.A.39) family
HMBIOMIE_03574	2.01e-206	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HMBIOMIE_03575	0.0	cydD	-	-	V	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding protein
HMBIOMIE_03576	0.0	cydC	-	-	V	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding
HMBIOMIE_03577	1.16e-243	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase, subunit II
HMBIOMIE_03578	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
HMBIOMIE_03579	3.97e-310	cimH	-	-	C	-	-	-	COG3493 Na citrate symporter
HMBIOMIE_03580	0.0	-	-	-	O	-	-	-	Peptidase family M48
HMBIOMIE_03582	3.56e-197	yxkH	-	-	G	-	-	-	Polysaccharide deacetylase
HMBIOMIE_03583	3.44e-261	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HMBIOMIE_03584	1.12e-209	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
HMBIOMIE_03585	1.52e-306	aldY	1.2.1.3, 1.2.1.67	-	C	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMBIOMIE_03586	9.32e-188	yxkD	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMBIOMIE_03587	2.88e-99	yxkC	-	-	S	-	-	-	Domain of unknown function (DUF4352)
HMBIOMIE_03588	2.11e-251	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMBIOMIE_03589	1.89e-100	-	-	-	S	-	-	-	Protein of unknown function (DUF1453)
HMBIOMIE_03590	4.02e-253	-	-	-	T	-	-	-	Signal transduction histidine kinase
HMBIOMIE_03591	5.66e-150	-	-	-	K	ko:K02479	-	ko00000,ko02022	helix_turn_helix, Lux Regulon
HMBIOMIE_03592	7.76e-299	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HMBIOMIE_03595	2.57e-114	yxjI	-	-	S	-	-	-	LURP-one-related
HMBIOMIE_03596	7.74e-280	yxjG	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
HMBIOMIE_03597	9.77e-279	yxjG	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
HMBIOMIE_03598	5.83e-176	yxjF	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
HMBIOMIE_03599	5.91e-151	scoB	2.8.3.5	-	I	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
HMBIOMIE_03600	4.65e-168	scoA	2.8.3.5	-	I	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMBIOMIE_03601	0.0	yxjC	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
HMBIOMIE_03602	4.55e-206	yxjB	2.1.1.187	-	Q	ko:K00563	-	ko00000,ko01000,ko03009	Methyltransferase domain
HMBIOMIE_03603	2.1e-269	nupG	-	-	F	ko:K16323	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMBIOMIE_03604	2.96e-29	-	-	-	T	-	-	-	Domain of unknown function (DUF4163)
HMBIOMIE_03605	9.65e-65	yxiS	-	-	-	-	-	-	-
HMBIOMIE_03606	0.0	katE	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
HMBIOMIE_03607	2e-284	citH	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
HMBIOMIE_03608	3.06e-184	bglS	-	-	M	-	-	-	licheninase activity
HMBIOMIE_03609	5.66e-193	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
HMBIOMIE_03610	5.09e-141	-	-	-	-	-	-	-	-
HMBIOMIE_03611	6.57e-293	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	COG2270 Permeases of the major facilitator superfamily
HMBIOMIE_03612	0.0	dbpA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
HMBIOMIE_03613	3.28e-279	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HMBIOMIE_03616	5.53e-65	yxiJ	-	-	S	-	-	-	YxiJ-like protein
HMBIOMIE_03617	3.79e-125	yxiI	-	-	S	-	-	-	Protein of unknown function (DUF2716)
HMBIOMIE_03618	6.22e-107	-	-	-	-	-	-	-	-
HMBIOMIE_03619	1.2e-57	-	-	-	-	-	-	-	-
HMBIOMIE_03620	3.46e-49	yxiG	-	-	-	-	-	-	-
HMBIOMIE_03621	1.12e-82	-	-	-	-	-	-	-	-
HMBIOMIE_03622	3.69e-111	-	-	-	-	-	-	-	-
HMBIOMIE_03623	1.09e-94	yxxG	-	-	-	-	-	-	-
HMBIOMIE_03624	0.0	wapA	-	-	M	-	-	-	COG3209 Rhs family protein
HMBIOMIE_03625	1.17e-216	yxxF	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_03626	8.5e-95	yxiE	-	-	T	-	-	-	Belongs to the universal stress protein A family
HMBIOMIE_03627	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HMBIOMIE_03628	0.0	bglP	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_03629	1.33e-67	-	-	-	-	-	-	-	-
HMBIOMIE_03630	9.25e-103	-	-	-	S	ko:K21494	-	ko00000,ko02048	SMI1 / KNR4 family
HMBIOMIE_03631	0.0	-	-	-	S	ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
HMBIOMIE_03632	2.3e-53	yxiC	-	-	S	-	-	-	Family of unknown function (DUF5344)
HMBIOMIE_03633	1.88e-37	-	-	-	S	-	-	-	Domain of unknown function (DUF5082)
HMBIOMIE_03634	0.0	yxiA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
HMBIOMIE_03635	7.02e-103	hutP	-	-	K	ko:K09683	-	ko00000,ko03000	Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
HMBIOMIE_03636	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Histidine ammonia-lyase
HMBIOMIE_03637	0.0	hutU	4.2.1.49	-	E	ko:K01712	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMBIOMIE_03638	2.44e-303	hutI	3.5.2.7	-	Q	ko:K01468	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Imidazolone-5-propionate hydrolase
HMBIOMIE_03639	4.85e-231	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
HMBIOMIE_03640	0.0	ybgF	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HMBIOMIE_03641	4.9e-300	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	phosphorylase
HMBIOMIE_03642	1.92e-263	nupC	-	-	F	ko:K11535	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMBIOMIE_03643	1.44e-150	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMBIOMIE_03644	4.26e-222	deoR	-	-	K	ko:K05346	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
HMBIOMIE_03645	9.11e-198	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1206)
HMBIOMIE_03646	4.86e-259	eutH	-	-	E	ko:K04023	-	ko00000	Ethanolamine utilisation protein, EutH
HMBIOMIE_03647	0.0	yxeQ	-	-	S	-	-	-	MmgE/PrpD family
HMBIOMIE_03648	5.21e-275	yxeP	-	-	E	ko:K21613	-	ko00000,ko01000,ko01002	hydrolase activity
HMBIOMIE_03649	1.67e-171	yxeO	-	-	P	ko:K16960,ko:K16963	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_03650	1.81e-149	yxeN	-	-	P	ko:K10009,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
HMBIOMIE_03651	4.3e-186	yxeM	-	-	M	ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
HMBIOMIE_03652	1.54e-121	yxeL	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HMBIOMIE_03653	0.0	yxeK	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMBIOMIE_03655	2.17e-243	yxeI	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
HMBIOMIE_03656	1.4e-194	yxeH	-	-	S	-	-	-	hydrolases of the HAD superfamily
HMBIOMIE_03659	7.32e-42	yxeE	-	-	-	-	-	-	-
HMBIOMIE_03660	2.66e-28	yxeD	-	-	-	-	-	-	-
HMBIOMIE_03661	6.79e-91	-	-	-	-	-	-	-	-
HMBIOMIE_03662	7.4e-227	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_03663	5.95e-77	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HMBIOMIE_03664	0.0	yxdM	-	-	V	ko:K11636	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
HMBIOMIE_03665	9.39e-182	yxdL	-	-	V	ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HMBIOMIE_03666	4.47e-230	yxdK	2.7.13.3	-	T	ko:K11633	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_03667	2.8e-160	yxdJ	-	-	T	ko:K02483,ko:K11634	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_03668	9.47e-203	fbaA	4.1.2.13, 4.1.2.29	-	F	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
HMBIOMIE_03669	2.29e-193	iolI	5.3.99.11	-	G	ko:K06606	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
HMBIOMIE_03670	1.08e-212	iolH	-	-	G	ko:K06605	-	ko00000	Xylose isomerase-like TIM barrel
HMBIOMIE_03671	4.44e-251	iolG	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
HMBIOMIE_03672	4.68e-295	iolF	-	-	EGP	ko:K06610	-	ko00000,ko02000	Major facilitator superfamily
HMBIOMIE_03673	1.74e-222	iolE	4.2.1.44	-	G	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
HMBIOMIE_03674	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
HMBIOMIE_03675	2.13e-228	iolC	2.7.1.92	-	G	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
HMBIOMIE_03676	1.46e-201	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
HMBIOMIE_03677	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
HMBIOMIE_03678	1.56e-177	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
HMBIOMIE_03679	3.52e-224	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
HMBIOMIE_03681	1.23e-63	yxcD	-	-	S	-	-	-	Protein of unknown function (DUF2653)
HMBIOMIE_03682	4.16e-313	csbC	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_03683	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Molecular chaperone. Has ATPase activity
HMBIOMIE_03685	8.38e-193	yxbG	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
HMBIOMIE_03686	1.03e-265	yxbF	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HMBIOMIE_03687	2.4e-313	aldX	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HMBIOMIE_03688	2.09e-16	yxaI	-	-	S	-	-	-	membrane protein domain
HMBIOMIE_03689	2.63e-137	yxaL	-	-	S	-	-	-	PQQ-like domain
HMBIOMIE_03690	1.43e-85	-	-	-	S	-	-	-	Family of unknown function (DUF5391)
HMBIOMIE_03691	4.7e-98	yxaI	-	-	S	-	-	-	membrane protein domain
HMBIOMIE_03692	3.75e-286	-	-	-	P	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
HMBIOMIE_03693	1.05e-250	-	1.13.11.24	-	S	ko:K07155	-	ko00000,ko01000	AraC-like ligand binding domain
HMBIOMIE_03694	3.91e-130	yxaF	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
HMBIOMIE_03695	4.3e-255	yxnA	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HMBIOMIE_03696	3.95e-93	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_03697	2.53e-78	-	-	-	S	ko:K06518	-	ko00000,ko02000	LrgA family
HMBIOMIE_03698	1.27e-152	yxaC	-	-	M	-	-	-	effector of murein hydrolase
HMBIOMIE_03699	8.52e-244	-	-	-	GM	ko:K19426	-	ko00000,ko01000	Polysaccharide pyruvyl transferase
HMBIOMIE_03700	5.73e-264	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
HMBIOMIE_03701	3.63e-163	gntR	-	-	K	ko:K11476	-	ko00000,ko03000	transcriptional
HMBIOMIE_03702	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HMBIOMIE_03703	5.87e-295	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
HMBIOMIE_03704	0.0	gntZ	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMBIOMIE_03705	9.33e-136	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	Alkyl hydroperoxide reductase
HMBIOMIE_03706	0.0	ahpF	-	-	O	ko:K03387	-	ko00000,ko01000	Alkyl hydroperoxide reductase
HMBIOMIE_03707	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HMBIOMIE_03708	6.69e-47	-	2.7.1.199	-	G	ko:K02777,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMBIOMIE_03709	2.38e-160	yydK	-	-	K	ko:K03489	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_03710	3.99e-22	-	-	-	-	-	-	-	-
HMBIOMIE_03711	3.7e-150	-	-	-	S	ko:K16916	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
HMBIOMIE_03712	2.06e-143	-	-	-	P	ko:K16917	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HMBIOMIE_03713	6.31e-173	-	-	-	O	ko:K16922	-	ko00000,ko01002	Peptidase M50
HMBIOMIE_03714	7.8e-237	-	-	-	S	-	-	-	Radical SAM superfamily
HMBIOMIE_03715	8.12e-17	-	-	-	-	-	-	-	-
HMBIOMIE_03716	0.0	fbp	3.1.3.11	-	G	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Firmicute fructose-1,6-bisphosphatase
HMBIOMIE_03717	0.0	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2326)
HMBIOMIE_03718	7.17e-86	-	-	-	-	-	-	-	-
HMBIOMIE_03719	0.0	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HMBIOMIE_03720	1.23e-106	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMBIOMIE_03722	1.25e-93	-	-	-	-	-	-	-	-
HMBIOMIE_03723	1.81e-297	yycR	1.1.1.1, 1.1.1.284, 1.2.1.46	-	E	ko:K00121,ko:K00148	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
HMBIOMIE_03725	1.7e-45	yycQ	-	-	S	-	-	-	Protein of unknown function (DUF2651)
HMBIOMIE_03726	2.88e-271	yycP	-	-	-	-	-	-	-
HMBIOMIE_03727	1.96e-168	yycO	-	-	S	-	-	-	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HMBIOMIE_03728	3.69e-111	yycN	-	-	K	-	-	-	Acetyltransferase
HMBIOMIE_03729	1.23e-238	-	-	-	S	-	-	-	aspartate phosphatase
HMBIOMIE_03731	3.22e-213	rocF	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
HMBIOMIE_03732	0.0	rocE	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
HMBIOMIE_03733	3.52e-295	rocD	2.6.1.13	-	E	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Catalyzes the interconversion of ornithine to glutamate semialdehyde
HMBIOMIE_03734	0.0	rocR	-	-	KT	ko:K06714	-	ko00000,ko03000	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
HMBIOMIE_03735	2.42e-281	yyxA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMBIOMIE_03736	4.01e-191	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
HMBIOMIE_03737	1.2e-200	yycI	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03738	0.0	yycH	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03739	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_03740	1.45e-172	yycF	-	-	T	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
HMBIOMIE_03745	6.38e-315	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMBIOMIE_03746	1.19e-101	yycE	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_03747	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HMBIOMIE_03748	3.48e-40	yycD	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
HMBIOMIE_03750	1.89e-22	yycC	-	-	K	-	-	-	YycC-like protein
HMBIOMIE_03751	4.19e-283	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
HMBIOMIE_03752	0.0	ykcB	-	-	M	-	-	-	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HMBIOMIE_03753	2.74e-96	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
HMBIOMIE_03754	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
HMBIOMIE_03755	8.66e-204	yybS	-	-	S	-	-	-	membrane
HMBIOMIE_03757	2.89e-110	cotF	-	-	M	ko:K06329	-	ko00000	Spore coat protein
HMBIOMIE_03758	1.3e-87	yybR	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03759	4.89e-210	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
HMBIOMIE_03760	2.34e-92	-	-	-	-	-	-	-	-
HMBIOMIE_03762	6.8e-308	yybO	-	-	G	ko:K03535,ko:K08191	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_03763	3.44e-22	-	-	-	-	-	-	-	-
HMBIOMIE_03764	1.61e-102	yybN	-	-	S	-	-	-	Protein of unknown function (DUF2712)
HMBIOMIE_03765	3.78e-169	-	-	-	-	-	-	-	-
HMBIOMIE_03766	5.36e-157	-	-	-	-	-	-	-	-
HMBIOMIE_03767	2.34e-163	-	-	-	S	-	-	-	Protein of unknown function (DUF2705)
HMBIOMIE_03768	1.14e-149	yybJ	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HMBIOMIE_03769	4.35e-194	-	-	-	-	-	-	-	-
HMBIOMIE_03770	3.02e-88	-	-	-	S	-	-	-	SnoaL-like domain
HMBIOMIE_03771	1.46e-164	yybG	-	-	S	-	-	-	Pentapeptide repeat-containing protein
HMBIOMIE_03772	3.31e-281	yybF	-	-	EGP	ko:K08224	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_03773	1.36e-212	yybE	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03774	7.91e-104	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_03775	1.27e-99	yybC	-	-	-	-	-	-	-
HMBIOMIE_03776	5.29e-165	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
HMBIOMIE_03777	4.54e-100	yybA	-	-	K	-	-	-	transcriptional
HMBIOMIE_03778	2.45e-103	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_03779	8.73e-132	yyaS	-	-	S	ko:K07149	-	ko00000	Membrane
HMBIOMIE_03780	4.03e-130	-	-	-	K	ko:K19273	-	ko00000,ko01000,ko01504	Acetyltransferase (GNAT) domain
HMBIOMIE_03781	4.32e-81	-	-	-	S	-	-	-	YjbR
HMBIOMIE_03782	1.67e-134	yyaP	-	-	H	-	-	-	RibD C-terminal domain
HMBIOMIE_03783	0.0	tetL	-	-	EGP	ko:K08168	-	ko00000,ko00002,ko01504,ko02000	COG0477 Permeases of the major facilitator superfamily
HMBIOMIE_03784	1.46e-58	yyaL	-	-	O	ko:K06888	-	ko00000	Highly conserved protein containing a thioredoxin domain
HMBIOMIE_03785	1.34e-88	-	-	-	K	-	-	-	MerR HTH family regulatory protein
HMBIOMIE_03786	1.99e-207	-	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_03787	0.0	yyaL	-	-	O	ko:K06888	-	ko00000	COG1331 Highly conserved protein containing a thioredoxin domain
HMBIOMIE_03788	8.91e-217	yyaK	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HMBIOMIE_03789	0.0	-	-	-	EGP	ko:K08369	-	ko00000,ko02000	Major facilitator superfamily
HMBIOMIE_03790	1.14e-130	vatD	2.3.1.28, 2.3.1.79	-	S	ko:K00638,ko:K00661,ko:K18234	-	br01600,ko00000,ko01000,ko01504	Bacterial transferase hexapeptide (six repeats)
HMBIOMIE_03791	7.2e-90	yyaH	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HMBIOMIE_03792	3.03e-230	ccpB	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03793	2.07e-187	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HMBIOMIE_03794	4.25e-49	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMBIOMIE_03795	1.81e-103	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HMBIOMIE_03796	1.01e-61	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
HMBIOMIE_03797	5.65e-256	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HMBIOMIE_03798	0.0	yyaE	-	-	C	-	-	-	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HMBIOMIE_03799	7.41e-45	yyzM	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03800	5.34e-227	yyaD	-	-	S	-	-	-	Membrane
HMBIOMIE_03801	9.15e-145	yyaC	-	-	S	-	-	-	Sporulation protein YyaC
HMBIOMIE_03802	3.96e-191	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HMBIOMIE_03803	4.79e-173	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	COG1192 ATPases involved in chromosome partitioning
HMBIOMIE_03804	2.27e-98	-	-	-	S	-	-	-	Bacterial PH domain
HMBIOMIE_03805	2.58e-192	noc	-	-	D	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
HMBIOMIE_03806	1.01e-167	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
HMBIOMIE_03807	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HMBIOMIE_03808	4.53e-316	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMBIOMIE_03809	1.83e-141	jag	-	-	S	ko:K06346	-	ko00000	single-stranded nucleic acid binding R3H
HMBIOMIE_03810	9.29e-179	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HMBIOMIE_03811	5.7e-71	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HMBIOMIE_03812	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMBIOMIE_03813	9.88e-263	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HMBIOMIE_03814	2.24e-45	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain
HMBIOMIE_03815	1.85e-263	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMBIOMIE_03816	1.25e-51	yaaB	-	-	S	-	-	-	Domain of unknown function (DUF370)
HMBIOMIE_03817	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMBIOMIE_03818	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMBIOMIE_03819	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
HMBIOMIE_03820	2.06e-170	-	-	-	S	-	-	-	Thymidylate synthase
HMBIOMIE_03826	2.24e-41	-	-	-	S	ko:K06418,ko:K06419,ko:K06420	-	ko00000	spore protein
HMBIOMIE_03827	1.71e-38	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HMBIOMIE_03828	1.46e-165	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HMBIOMIE_03836	5.61e-116	-	-	-	L	-	-	-	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HMBIOMIE_03838	1.01e-33	-	-	-	-	-	-	-	-
HMBIOMIE_03839	2.43e-65	kamA	5.4.3.2	-	E	ko:K01843	ko00310,map00310	ko00000,ko00001,ko01000	lysine 2,3-aminomutase
HMBIOMIE_03840	1.4e-62	yokU	-	-	S	-	-	-	YokU-like protein, putative antitoxin
HMBIOMIE_03841	7.3e-50	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
HMBIOMIE_03842	1.29e-159	yodN	-	-	-	-	-	-	-
HMBIOMIE_03844	5.18e-34	yozD	-	-	S	-	-	-	YozD-like protein
HMBIOMIE_03845	6.67e-137	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
HMBIOMIE_03846	1.17e-71	yodL	-	-	S	-	-	-	YodL-like
HMBIOMIE_03847	2.08e-12	-	-	-	-	-	-	-	-
HMBIOMIE_03848	1.68e-163	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
HMBIOMIE_03849	1.33e-189	yodJ	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
HMBIOMIE_03850	2.93e-42	yodI	-	-	-	-	-	-	-
HMBIOMIE_03851	3.69e-167	yodH	-	-	Q	-	-	-	Methyltransferase
HMBIOMIE_03852	0.0	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
HMBIOMIE_03853	0.0	yodF	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMBIOMIE_03854	2.36e-38	-	-	-	S	-	-	-	Protein of unknown function (DUF3311)
HMBIOMIE_03855	1.18e-223	yodE	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
HMBIOMIE_03856	1.31e-146	yahD	-	-	S	ko:K06999	-	ko00000	Carboxylesterase
HMBIOMIE_03857	1.92e-140	yodC	-	-	C	-	-	-	nitroreductase
HMBIOMIE_03858	1.37e-76	yodB	-	-	K	-	-	-	transcriptional
HMBIOMIE_03859	2.05e-86	iolK	-	-	S	-	-	-	tautomerase
HMBIOMIE_03860	9.24e-290	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
HMBIOMIE_03861	1.95e-14	-	-	-	-	-	-	-	-
HMBIOMIE_03862	1.89e-100	yozR	-	-	S	-	-	-	COG0071 Molecular chaperone (small heat shock protein)
HMBIOMIE_03863	5.49e-206	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	-transporter
HMBIOMIE_03864	1.85e-58	-	-	-	-	-	-	-	-
HMBIOMIE_03865	2.72e-78	yojF	-	-	S	-	-	-	Protein of unknown function (DUF1806)
HMBIOMIE_03866	1.84e-161	yojG	-	-	S	ko:K22135	-	ko00000,ko01000	deacetylase
HMBIOMIE_03867	1.01e-193	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
HMBIOMIE_03868	1.02e-313	norM	-	-	V	ko:K03327	-	ko00000,ko02000	Multidrug efflux pump
HMBIOMIE_03870	4.31e-141	dacB	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMBIOMIE_03871	1.13e-293	yojK	-	-	CG	-	-	-	UDP-glucoronosyl and UDP-glucosyl transferase
HMBIOMIE_03872	2.62e-267	-	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
HMBIOMIE_03873	8.54e-141	sodC	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMBIOMIE_03874	1.33e-207	yojN	-	-	S	ko:K04748	-	ko00000	ATPase family associated with various cellular activities (AAA)
HMBIOMIE_03875	0.0	yojO	-	-	P	-	-	-	Von Willebrand factor
HMBIOMIE_03876	0.0	odhA	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
HMBIOMIE_03877	2.13e-263	odhB	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
HMBIOMIE_03878	4.7e-214	yocS	-	-	S	ko:K03453	-	ko00000	-transporter
HMBIOMIE_03879	8.78e-300	yocR	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
HMBIOMIE_03880	2.26e-210	sodF	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Superoxide dismutase
HMBIOMIE_03881	0.0	sqhC	4.2.1.137	-	I	ko:K18115	-	ko00000,ko01000	COG1657 Squalene cyclase
HMBIOMIE_03882	0.0	dhaS	1.2.1.3, 1.2.1.39	-	C	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HMBIOMIE_03883	1.91e-42	yozC	-	-	-	-	-	-	-
HMBIOMIE_03884	2.17e-74	yozO	-	-	S	-	-	-	Bacterial PH domain
HMBIOMIE_03885	1.83e-49	yocN	-	-	-	-	-	-	-
HMBIOMIE_03886	2.94e-55	yozN	-	-	-	-	-	-	-
HMBIOMIE_03887	6.6e-115	yocM	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HMBIOMIE_03888	7.29e-46	-	-	-	-	-	-	-	-
HMBIOMIE_03889	1.23e-69	yocL	-	-	-	-	-	-	-
HMBIOMIE_03890	1.42e-107	yocK	-	-	T	-	-	-	general stress protein
HMBIOMIE_03891	1.46e-147	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HMBIOMIE_03892	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
HMBIOMIE_03893	2.89e-175	yocH	-	-	M	-	-	-	COG1388 FOG LysM repeat
HMBIOMIE_03894	4.71e-135	desR	-	-	T	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_03895	1.22e-252	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_03896	3.99e-258	des	1.14.19.23, 1.14.19.45	-	I	ko:K10255	ko02020,map02020	ko00000,ko00001,ko01000,ko01004	fatty acid desaturase
HMBIOMIE_03897	1.21e-243	yocD	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	peptidase S66
HMBIOMIE_03898	1.32e-122	yocC	-	-	-	-	-	-	-
HMBIOMIE_03899	4.49e-186	-	-	-	-	-	-	-	-
HMBIOMIE_03900	3.97e-119	yozB	-	-	S	ko:K08976	-	ko00000	membrane
HMBIOMIE_03901	3.28e-157	yocA	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HMBIOMIE_03902	8.12e-69	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	transcriptional
HMBIOMIE_03903	7.69e-123	yobW	-	-	-	-	-	-	-
HMBIOMIE_03904	2.05e-229	yobV	-	-	K	-	-	-	WYL domain
HMBIOMIE_03905	1.55e-114	-	-	-	K	-	-	-	Bacterial transcription activator, effector binding domain
HMBIOMIE_03906	1.34e-169	yobT	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
HMBIOMIE_03907	9.22e-129	yobS	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_03908	1.29e-183	-	-	-	J	-	-	-	FR47-like protein
HMBIOMIE_03909	5.23e-175	yobQ	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HMBIOMIE_03910	2.21e-72	csaA	-	-	J	ko:K06878	-	ko00000	tRNA-binding protein
HMBIOMIE_03911	0.0	yobO	-	-	M	-	-	-	Pectate lyase superfamily protein
HMBIOMIE_03912	0.0	iaaM	1.4.3.4	-	E	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	ko00000,ko00001,ko00002,ko01000	COG1231 Monoamine oxidase
HMBIOMIE_03913	4.3e-136	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
HMBIOMIE_03914	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_03915	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_03916	0.0	-	6.3.2.14	-	Q	ko:K02364,ko:K15656,ko:K15668	ko01053,ko01054,ko01110,ko01130,ko02024,map01053,map01054,map01110,map01130,map02024	ko00000,ko00001,ko01000,ko01008	amino acid activation for nonribosomal peptide biosynthetic process
HMBIOMIE_03917	2.12e-84	yngL	-	-	S	-	-	-	Protein of unknown function (DUF1360)
HMBIOMIE_03918	0.0	yngK	-	-	T	-	-	-	Glycosyl hydrolase-like 10
HMBIOMIE_03919	4.3e-41	-	-	-	S	-	-	-	Family of unknown function (DUF5367)
HMBIOMIE_03920	1.31e-268	yngJ	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
HMBIOMIE_03921	0.0	yngI	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
HMBIOMIE_03922	0.0	yngH	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase
HMBIOMIE_03923	1.23e-43	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin carboxyl carrier protein
HMBIOMIE_03924	7.02e-214	yngG	4.1.3.4	-	E	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA lyase
HMBIOMIE_03925	1.48e-175	yngF	-	-	I	-	-	-	Belongs to the enoyl-CoA hydratase isomerase family
HMBIOMIE_03926	0.0	yngE	-	-	I	-	-	-	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
HMBIOMIE_03927	2.3e-109	yngD	-	-	S	ko:K07097	-	ko00000	phosphohydrolase (DHH superfamily)
HMBIOMIE_03928	1.46e-159	yngD	-	-	S	ko:K07097	-	ko00000	phosphohydrolase (DHH superfamily)
HMBIOMIE_03929	2.01e-134	yngC	-	-	S	-	-	-	membrane-associated protein
HMBIOMIE_03930	2.74e-210	yngB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HMBIOMIE_03931	1.04e-104	yngA	-	-	S	-	-	-	membrane
HMBIOMIE_03932	0.0	xynD	3.2.1.55	CBM6,GH43	G	ko:K15921	ko00520,map00520	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
HMBIOMIE_03933	0.0	ynfF	3.2.1.136	GH5	M	ko:K15924	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 30 family
HMBIOMIE_03935	0.0	bglC5	3.2.1.4	GH5,GH9	G	ko:K01179	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	PFAM glycoside hydrolase family 5
HMBIOMIE_03936	0.0	alsT	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
HMBIOMIE_03937	1.06e-75	ynfC	-	-	-	-	-	-	-
HMBIOMIE_03938	1.82e-18	-	-	-	-	-	-	-	-
HMBIOMIE_03939	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMBIOMIE_03940	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HMBIOMIE_03941	1.21e-90	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
HMBIOMIE_03942	5.48e-122	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HMBIOMIE_03943	8.97e-65	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
HMBIOMIE_03944	1.63e-71	yneQ	-	-	-	-	-	-	-
HMBIOMIE_03945	1.4e-95	yneP	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
HMBIOMIE_03946	6.62e-48	tlp	-	-	S	ko:K06434	-	ko00000	Belongs to the Tlp family
HMBIOMIE_03948	9.26e-10	-	-	-	S	-	-	-	Fur-regulated basic protein B
HMBIOMIE_03949	3.74e-120	yneN	-	-	CO	-	-	-	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HMBIOMIE_03950	0.0	citB	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMBIOMIE_03951	3.75e-21	sspO	-	-	S	ko:K06432	-	ko00000	Belongs to the SspO family
HMBIOMIE_03952	5.65e-27	sspP	-	-	S	ko:K06433	-	ko00000	Belongs to the SspP family
HMBIOMIE_03953	1.21e-86	cotM	-	-	O	ko:K06335	-	ko00000	Spore coat protein
HMBIOMIE_03954	2.79e-97	yneK	-	-	S	-	-	-	Protein of unknown function (DUF2621)
HMBIOMIE_03955	2.51e-98	yneJ	-	-	O	-	-	-	COG4846 Membrane protein involved in cytochrome C biogenesis
HMBIOMIE_03956	7.38e-78	ccdB	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
HMBIOMIE_03957	4.13e-165	ccdA	-	-	O	ko:K06196	-	ko00000,ko02000	cytochrome c biogenesis protein
HMBIOMIE_03958	4.59e-21	ynzD	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
HMBIOMIE_03959	4.36e-39	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
HMBIOMIE_03960	2.18e-106	yneE	-	-	S	-	-	-	Sporulation inhibitor of replication protein sirA
HMBIOMIE_03961	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMBIOMIE_03962	1.15e-43	ynzC	-	-	S	-	-	-	UPF0291 protein
HMBIOMIE_03963	3.97e-145	yneB	-	-	L	-	-	-	resolvase
HMBIOMIE_03964	8.5e-65	yneA	-	-	D	-	-	-	Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
HMBIOMIE_03965	7.22e-142	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMBIOMIE_03967	4.44e-104	fosB	-	-	H	ko:K11210,ko:K21252	-	ko00000,ko01000,ko01504	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
HMBIOMIE_03968	1.32e-96	yndM	-	-	S	-	-	-	Protein of unknown function (DUF2512)
HMBIOMIE_03969	1.68e-177	yndL	-	-	S	-	-	-	Replication protein
HMBIOMIE_03971	0.0	yndJ	-	-	S	-	-	-	YndJ-like protein
HMBIOMIE_03972	1.26e-151	-	-	-	S	-	-	-	Domain of unknown function (DUF4166)
HMBIOMIE_03973	9.15e-199	yndG	-	-	S	-	-	-	DoxX-like family
HMBIOMIE_03974	9.64e-290	-	-	-	S	ko:K06293,ko:K06312	-	ko00000	Spore germination protein
HMBIOMIE_03975	2.38e-251	yndE7	-	-	U	ko:K06311	-	ko00000,ko02000	Spore germination
HMBIOMIE_03976	0.0	yndD1	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
HMBIOMIE_03979	3.12e-104	yndB	-	-	S	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
HMBIOMIE_03980	8.92e-96	-	-	-	-	-	-	-	-
HMBIOMIE_03981	2.37e-34	tatA	-	-	U	ko:K03116,ko:K03117,ko:K03646	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02000,ko02044	protein secretion
HMBIOMIE_03984	1.55e-172	-	-	-	S	-	-	-	Domain of unknown function, YrpD
HMBIOMIE_03986	2.61e-173	-	-	-	S	-	-	-	Thymidylate synthase
HMBIOMIE_03987	2.21e-42	csfB	-	-	S	-	-	-	Inhibitor of sigma-G Gin
HMBIOMIE_03988	3.28e-133	xpaC	-	-	S	-	-	-	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HMBIOMIE_03989	5.05e-260	yaaN	-	-	P	-	-	-	Belongs to the TelA family
HMBIOMIE_03990	0.0	yaaO	-	-	E	-	-	-	Orn Lys Arg decarboxylase
HMBIOMIE_03991	9.43e-146	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMBIOMIE_03992	1.02e-72	yaaQ	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_03993	1.48e-94	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
HMBIOMIE_03994	9.28e-230	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HMBIOMIE_03995	6.33e-189	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
HMBIOMIE_03996	1.53e-56	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
HMBIOMIE_03997	1.14e-177	yabB	2.1.1.223	-	S	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Conserved hypothetical protein 95
HMBIOMIE_03998	5.95e-65	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
HMBIOMIE_03999	2.95e-207	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HMBIOMIE_04000	1.51e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	COG2002 Regulators of stationary sporulation gene expression
HMBIOMIE_04001	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMBIOMIE_04002	4.85e-183	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD
HMBIOMIE_04003	1.91e-283	yabE	-	-	T	-	-	-	protein conserved in bacteria
HMBIOMIE_04004	1.05e-127	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMBIOMIE_04005	1.24e-199	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HMBIOMIE_04006	1.11e-198	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
HMBIOMIE_04007	5.32e-53	veg	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_04008	2.34e-207	ispE	2.7.1.148	-	I	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMBIOMIE_04009	4.66e-196	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
HMBIOMIE_04010	3.45e-83	yabJ	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	translation initiation inhibitor, yjgF family
HMBIOMIE_04011	2.45e-63	spoVG	-	-	D	ko:K06412	-	ko00000	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
HMBIOMIE_04012	2.58e-309	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMBIOMIE_04013	1.22e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMBIOMIE_04014	1.45e-136	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMBIOMIE_04015	2.03e-135	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HMBIOMIE_04016	6.36e-54	yabK	-	-	S	-	-	-	Peptide ABC transporter permease
HMBIOMIE_04017	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMBIOMIE_04018	5.88e-121	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein
HMBIOMIE_04019	0.0	yabM	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
HMBIOMIE_04020	0.0	yabN	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
HMBIOMIE_04021	4.22e-50	yabO	-	-	J	-	-	-	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
HMBIOMIE_04022	1.91e-66	yabP	-	-	S	-	-	-	Sporulation protein YabP
HMBIOMIE_04023	5.21e-138	yabQ	-	-	S	-	-	-	spore cortex biosynthesis protein
HMBIOMIE_04024	4.18e-75	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
HMBIOMIE_04025	2.49e-82	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
HMBIOMIE_04028	0.0	spoIIE	3.1.3.16	-	KT	ko:K06382	-	ko00000,ko01000	stage II sporulation protein E
HMBIOMIE_04029	5.61e-168	yabS	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
HMBIOMIE_04030	1.15e-234	yabT	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HMBIOMIE_04031	0.0	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HMBIOMIE_04032	4.82e-121	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMBIOMIE_04033	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMBIOMIE_04034	6.92e-189	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HMBIOMIE_04035	9.54e-208	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMBIOMIE_04036	6.68e-196	yacD	5.2.1.8	-	O	ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl isomerase
HMBIOMIE_04037	3.77e-218	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HMBIOMIE_04038	0.0	pabB	2.6.1.85	-	EH	ko:K01665	ko00790,map00790	ko00000,ko00001,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMBIOMIE_04039	1.03e-137	pabA	2.6.1.85	-	EH	ko:K01664	ko00790,map00790	ko00000,ko00001,ko01000	Anthranilate synthase
HMBIOMIE_04040	2.27e-216	pabC	4.1.3.38	-	EH	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	4-amino-4-deoxychorismate lyase
HMBIOMIE_04041	3.32e-205	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMBIOMIE_04042	2.78e-82	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMBIOMIE_04043	4.56e-115	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMBIOMIE_04044	1.81e-41	yazB	-	-	K	-	-	-	transcriptional
HMBIOMIE_04045	7.88e-244	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMBIOMIE_04046	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
HMBIOMIE_04047	8.72e-100	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
HMBIOMIE_04048	2.76e-65	mcsA	-	-	S	ko:K19411	-	ko00000	protein with conserved CXXC pairs
HMBIOMIE_04049	7.74e-257	mcsB	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
HMBIOMIE_04050	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
HMBIOMIE_04051	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMBIOMIE_04052	3.8e-251	disA	2.7.7.85	-	L	ko:K07067	-	ko00000,ko01000	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMBIOMIE_04053	2.57e-252	yacL	-	-	S	-	-	-	COG4956 Integral membrane protein (PIN domain superfamily)
HMBIOMIE_04054	1.82e-162	ispD	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
HMBIOMIE_04055	6.35e-113	ispF	2.7.7.60, 4.6.1.12	-	I	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
HMBIOMIE_04056	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMBIOMIE_04057	1.91e-152	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
HMBIOMIE_04058	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HMBIOMIE_04059	1.68e-94	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMBIOMIE_04060	3.52e-173	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMBIOMIE_04061	3.31e-114	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
HMBIOMIE_04062	3.27e-149	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
HMBIOMIE_04063	2.65e-32	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HMBIOMIE_04064	1.37e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
HMBIOMIE_04065	3.4e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMBIOMIE_04066	1.82e-162	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HMBIOMIE_04067	4.03e-104	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMBIOMIE_04068	2.84e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HMBIOMIE_04069	5.1e-140	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
HMBIOMIE_04070	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMBIOMIE_04071	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMBIOMIE_04072	1.99e-44	rplGB	-	-	J	ko:K07590	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the eukaryotic ribosomal protein eL8 family
HMBIOMIE_04073	6.67e-94	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMBIOMIE_04074	4.85e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HMBIOMIE_04075	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMBIOMIE_04076	2.01e-287	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMBIOMIE_04077	8.78e-238	ybaC	-	-	S	-	-	-	Alpha/beta hydrolase family
HMBIOMIE_04078	2.58e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
HMBIOMIE_04079	7.2e-144	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMBIOMIE_04080	7.43e-136	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
HMBIOMIE_04081	3.27e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HMBIOMIE_04082	2.72e-200	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMBIOMIE_04083	2.83e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMBIOMIE_04084	9.23e-71	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMBIOMIE_04085	5.9e-152	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMBIOMIE_04086	1.96e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMBIOMIE_04087	1.88e-35	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
HMBIOMIE_04088	1.64e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMBIOMIE_04089	3.62e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMBIOMIE_04090	1.43e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMBIOMIE_04091	7.72e-122	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMBIOMIE_04092	1.43e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMBIOMIE_04093	3.11e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMBIOMIE_04094	4.47e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMBIOMIE_04095	2.89e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMBIOMIE_04096	9.16e-111	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMBIOMIE_04097	1.59e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
HMBIOMIE_04098	7.32e-95	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
HMBIOMIE_04099	5.7e-298	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HMBIOMIE_04100	6.17e-158	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HMBIOMIE_04101	2.32e-182	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
HMBIOMIE_04102	2.92e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMBIOMIE_04103	2.45e-19	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
HMBIOMIE_04104	1.09e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMBIOMIE_04105	3.24e-84	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMBIOMIE_04106	7.01e-217	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMBIOMIE_04107	4.27e-77	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
HMBIOMIE_04108	7.5e-200	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMBIOMIE_04109	2.69e-197	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMBIOMIE_04110	1.6e-177	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMBIOMIE_04111	6.15e-182	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HMBIOMIE_04112	1.13e-102	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMBIOMIE_04113	4.28e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
HMBIOMIE_04114	6.15e-186	ybaJ	-	-	Q	-	-	-	Methyltransferase domain
HMBIOMIE_04115	2.54e-91	ybaK	-	-	S	-	-	-	Protein of unknown function (DUF2521)
HMBIOMIE_04116	3.16e-170	cwlD	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
HMBIOMIE_04117	4.47e-255	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
HMBIOMIE_04118	1.04e-122	gerD	-	-	-	ko:K06294	-	ko00000	-
HMBIOMIE_04119	5.95e-133	kbaA	-	-	S	ko:K06349	-	ko00000	Involved in the activation of the KinB signaling pathway of sporulation
HMBIOMIE_04120	3.54e-180	pdaB	-	-	G	-	-	-	Polysaccharide deacetylase
HMBIOMIE_04122	4.24e-146	ydeA	-	-	S	-	-	-	DJ-1/PfpI family
HMBIOMIE_04123	4.22e-41	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock
HMBIOMIE_04124	5.92e-102	ydeB	-	-	K	ko:K07736	-	ko00000,ko03000	Transcription factor
HMBIOMIE_04125	3.56e-184	gmT1	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HMBIOMIE_04126	2.18e-213	-	-	-	K	-	-	-	AraC-like ligand binding domain
HMBIOMIE_04127	2.37e-222	ydeD	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
HMBIOMIE_04128	4.06e-209	ydeE	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
HMBIOMIE_04129	0.0	-	-	-	K	-	-	-	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_04130	3.8e-277	ydeG	-	-	EGP	-	-	-	Major facilitator superfamily
HMBIOMIE_04131	9.2e-70	ydeH	-	-	-	-	-	-	-
HMBIOMIE_04132	6.99e-136	ydeI	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
HMBIOMIE_04133	5.17e-142	-	-	-	-	-	-	-	-
HMBIOMIE_04134	2.4e-41	-	-	-	S	-	-	-	SNARE associated Golgi protein
HMBIOMIE_04135	3.3e-19	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	PTS HPr component phosphorylation site
HMBIOMIE_04136	4.22e-111	-	-	-	K	-	-	-	Transcriptional regulator C-terminal region
HMBIOMIE_04137	4.66e-197	ydeK	-	-	EG	-	-	-	-transporter
HMBIOMIE_04138	0.0	ydeL	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_04139	3.68e-97	ydeM1	-	-	I	-	-	-	N-terminal half of MaoC dehydratase
HMBIOMIE_04140	8.6e-138	-	-	-	S	ko:K07002	-	ko00000	Serine hydrolase
HMBIOMIE_04141	1.33e-77	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
HMBIOMIE_04142	1.68e-196	ydeO	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
HMBIOMIE_04143	9.29e-256	ydeR	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
HMBIOMIE_04144	1.78e-134	ydeS	-	-	K	-	-	-	Transcriptional regulator
HMBIOMIE_04145	2.11e-75	arsR	-	-	K	ko:K03892,ko:K22043	-	ko00000,ko03000	transcriptional
HMBIOMIE_04146	1.06e-295	arsB	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMBIOMIE_04147	2.22e-188	-	-	-	J	-	-	-	GNAT acetyltransferase
HMBIOMIE_04148	2.5e-206	-	-	-	EG	-	-	-	EamA-like transporter family
HMBIOMIE_04149	0.0	ydfD	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
HMBIOMIE_04150	4.71e-148	ydfE	-	-	S	-	-	-	Flavin reductase like domain
HMBIOMIE_04151	7.44e-159	ydfF	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HMBIOMIE_04152	1.12e-103	-	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMBIOMIE_04154	3.37e-252	ydfH	2.7.13.3	-	T	ko:K11623	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HMBIOMIE_04155	2.3e-142	ydfI	-	-	K	ko:K11624	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
HMBIOMIE_04156	0.0	ydfJ	-	-	S	ko:K06994,ko:K11625	ko02020,map02020	ko00000,ko00001	drug exporters of the RND superfamily
HMBIOMIE_04157	4.44e-222	-	-	-	S	-	-	-	Alpha/beta hydrolase family
HMBIOMIE_04158	7.6e-149	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
HMBIOMIE_04159	6.84e-186	-	-	-	K	-	-	-	Bacterial transcription activator, effector binding domain
HMBIOMIE_04160	5.22e-199	ydfM	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMBIOMIE_04161	3.45e-145	ydfN	-	-	C	ko:K15976	-	ko00000,ko01000	nitroreductase
HMBIOMIE_04162	9.49e-239	ydfO	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
HMBIOMIE_04163	8.02e-84	ydfP	-	-	S	ko:K15977	-	ko00000	DoxX
HMBIOMIE_04164	9.63e-77	ydfQ	-	-	CO	-	-	-	Thioredoxin
HMBIOMIE_04165	2.4e-21	ydgA	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
HMBIOMIE_04166	5.33e-39	-	-	-	-	-	-	-	-
HMBIOMIE_04168	6.08e-153	ydfR	-	-	S	-	-	-	Protein of unknown function (DUF421)
HMBIOMIE_04169	4.44e-160	ydfS	-	-	S	-	-	-	Protein of unknown function (DUF421)
HMBIOMIE_04170	3.13e-99	cotP	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HMBIOMIE_04171	2.74e-50	ydgA	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
HMBIOMIE_04172	2.19e-56	ydgB	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
HMBIOMIE_04173	5.99e-130	ydgC	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HMBIOMIE_04174	7e-71	-	-	-	S	-	-	-	DoxX-like family
HMBIOMIE_04175	2.49e-114	yycN	-	-	K	-	-	-	Acetyltransferase
HMBIOMIE_04176	0.0	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
HMBIOMIE_04177	0.0	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
HMBIOMIE_04178	5.09e-119	-	-	-	S	-	-	-	DinB family
HMBIOMIE_04179	2.06e-104	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HMBIOMIE_04180	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	drug exporters of the RND superfamily
HMBIOMIE_04181	6.42e-147	ydgI	-	-	C	-	-	-	nitroreductase
HMBIOMIE_04182	1.15e-90	-	-	-	K	-	-	-	Winged helix DNA-binding domain
HMBIOMIE_04183	5.97e-267	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
HMBIOMIE_04184	1.77e-155	ydhB	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HMBIOMIE_04185	5.24e-158	ydhC	-	-	K	-	-	-	FCD
HMBIOMIE_04186	8.92e-310	ydhD	-	-	M	-	-	-	Glycosyl hydrolase
HMBIOMIE_04187	9.61e-290	ydhE	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
HMBIOMIE_04188	7.71e-166	-	-	-	-	-	-	-	-
HMBIOMIE_04189	0.0	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
HMBIOMIE_04190	9.93e-91	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
HMBIOMIE_04192	1.43e-112	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_04193	8.41e-235	ydhJ	-	-	S	ko:K06885	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HMBIOMIE_04194	1.15e-127	ydhK	-	-	M	-	-	-	Protein of unknown function (DUF1541)
HMBIOMIE_04195	6.3e-255	ydhL	-	-	EGP	ko:K18567	-	ko00000,ko02000	COG2814 Arabinose efflux permease
HMBIOMIE_04196	2.29e-64	ydhM	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_04197	5.86e-68	ydhN3	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HMBIOMIE_04198	3.23e-305	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HMBIOMIE_04199	0.0	ydhP	3.2.1.21, 3.2.1.86	GT1	G	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HMBIOMIE_04200	1.9e-171	ydhQ	-	-	K	ko:K03492	-	ko00000,ko03000	UTRA
HMBIOMIE_04201	9.28e-219	gmuE	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	COG1940 Transcriptional regulator sugar kinase
HMBIOMIE_04202	1.93e-244	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HMBIOMIE_04203	3.49e-273	ydhT1	3.2.1.78	GH26	G	ko:K01218	ko00051,ko02024,map00051,map02024	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 26 family
HMBIOMIE_04204	1.12e-98	ydhU	-	-	P	ko:K07217	-	ko00000	Catalase
HMBIOMIE_04205	7.94e-22	ydhU	-	-	P	ko:K07217	-	ko00000	Manganese containing catalase
HMBIOMIE_04209	4.32e-110	-	-	-	E	-	-	-	phosphoribosylanthranilate isomerase activity
HMBIOMIE_04210	0.0	xynP	-	-	G	ko:K03292	-	ko00000	MFS/sugar transport protein
HMBIOMIE_04211	0.0	xynB	3.2.1.37	GH43	G	ko:K01198	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
HMBIOMIE_04212	3.15e-278	xylR	-	-	GK	-	-	-	ROK family
HMBIOMIE_04213	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
HMBIOMIE_04214	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	xylulose kinase
HMBIOMIE_04215	2.92e-144	yokF	3.1.31.1	-	L	ko:K01174	-	ko00000,ko01000	RNA catabolic process
HMBIOMIE_04216	0.0	-	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HMBIOMIE_04217	3.05e-281	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMBIOMIE_04218	3.44e-110	-	-	-	S	-	-	-	Protein of unknown function (DUF2691)
HMBIOMIE_04219	3.01e-102	yncF	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Deoxyuridine 5'-triphosphate
HMBIOMIE_04220	7.54e-22	-	-	-	-	-	-	-	-
HMBIOMIE_04233	0.0	-	-	-	Q	ko:K15665	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_04234	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HMBIOMIE_04236	2.9e-254	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HMBIOMIE_04237	0.0	-	-	-	S	-	-	-	DNA-sulfur modification-associated
HMBIOMIE_04240	5.66e-159	-	-	-	-	-	-	-	-
HMBIOMIE_04241	0.0	-	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
HMBIOMIE_04242	1.52e-109	-	-	-	S	-	-	-	Phage tail protein
HMBIOMIE_04243	0.0	-	-	-	S	-	-	-	Pfam Transposase IS66
HMBIOMIE_04244	7.44e-193	-	-	-	-	-	-	-	-
HMBIOMIE_04245	0.0	XK27_08080	-	-	G	-	-	-	Exopolysaccharide biosynthesis protein
HMBIOMIE_04246	3.79e-112	-	-	-	S	-	-	-	N-acetylmuramoyl-L-alanine amidase activity
HMBIOMIE_04248	4.83e-50	-	-	-	S	-	-	-	Bacteriophage holin
HMBIOMIE_04249	9.92e-244	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
HMBIOMIE_04251	5.42e-146	dinB2	-	-	L	ko:K03502	-	ko00000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_04252	2.22e-58	dinB2	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_04253	1.52e-79	dinB2	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMBIOMIE_04254	2.05e-51	-	-	-	S	-	-	-	YolD-like protein
HMBIOMIE_04255	2.08e-64	-	-	-	-	-	-	-	-
HMBIOMIE_04256	0.0	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HMBIOMIE_04257	3.58e-202	-	-	-	-	-	-	-	-
HMBIOMIE_04258	6.69e-112	-	-	-	S	ko:K21488	-	ko00000,ko02048	SMI1-KNR4 cell-wall
HMBIOMIE_04259	1.45e-179	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	A nuclease of the HNH/ENDO VII superfamily with conserved LHH
HMBIOMIE_04260	1.05e-299	-	-	-	S	-	-	-	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
HMBIOMIE_04262	6.12e-225	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMBIOMIE_04263	4.4e-47	-	-	-	O	-	-	-	Glutaredoxin
HMBIOMIE_04264	5.17e-98	yncF	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Deoxyuridine 5'-triphosphate
HMBIOMIE_04265	1.9e-20	XK27_09885	-	-	V	-	-	-	COG4767 Glycopeptide antibiotics resistance protein
HMBIOMIE_04268	5.24e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF1643)
HMBIOMIE_04269	1.11e-155	-	-	-	-	-	-	-	-
HMBIOMIE_04271	8.95e-91	-	-	-	-	-	-	-	-
HMBIOMIE_04272	2.31e-105	-	-	-	-	-	-	-	-
HMBIOMIE_04273	9.83e-236	-	-	-	-	-	-	-	-
HMBIOMIE_04274	2.05e-121	-	-	-	-	-	-	-	-
HMBIOMIE_04275	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_04276	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_04277	0.0	-	-	-	S	-	-	-	Terminase-like family
HMBIOMIE_04278	1.81e-224	-	-	-	-	-	-	-	-
HMBIOMIE_04282	2.98e-271	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase superfamily domain
HMBIOMIE_04285	7.27e-56	-	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HMBIOMIE_04286	0.0	-	-	-	-	-	-	-	-
HMBIOMIE_04289	4.97e-259	-	-	-	-	-	-	-	-
HMBIOMIE_04305	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
HMBIOMIE_04306	4.54e-177	-	-	-	S	-	-	-	Pfam:DUF867
HMBIOMIE_04308	9.04e-16	-	-	-	S	-	-	-	YopX protein
HMBIOMIE_04311	4.68e-161	yoqW	-	-	S	-	-	-	Belongs to the SOS response-associated peptidase family
HMBIOMIE_04312	1.29e-190	ligB	6.5.1.1, 6.5.1.6, 6.5.1.7	-	L	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	ko00000,ko00001,ko01000,ko03032,ko03400	ATP-dependent DNA ligase
HMBIOMIE_04313	7.22e-102	-	-	-	-	-	-	-	-
HMBIOMIE_04317	4.78e-46	-	-	-	K	ko:K07727	-	ko00000,ko03000	Transcriptional regulator
HMBIOMIE_04322	0.000573	-	-	-	S	-	-	-	YopX protein
HMBIOMIE_04337	1.86e-138	-	-	-	S	-	-	-	protein conserved in bacteria
HMBIOMIE_04342	1.52e-103	tmk	2.1.1.45, 2.7.4.9	-	F	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	dTDP biosynthetic process
HMBIOMIE_04352	1.26e-26	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HMBIOMIE_04362	1.54e-82	-	-	-	S	-	-	-	NrdI Flavodoxin like
HMBIOMIE_04363	3.91e-244	-	-	-	A	-	-	-	Belongs to the 'phage' integrase family
HMBIOMIE_04364	9.13e-91	-	-	-	-	-	-	-	-
HMBIOMIE_04365	3.9e-111	-	-	-	-	-	-	-	-
HMBIOMIE_04368	2.12e-220	-	-	-	-	-	-	-	-
HMBIOMIE_04369	2.14e-74	-	-	-	-	-	-	-	-
HMBIOMIE_04372	1.58e-145	-	-	-	-	-	-	-	-
HMBIOMIE_04373	2.4e-169	-	-	-	-	-	-	-	-
HMBIOMIE_04374	2.71e-53	-	-	-	-	-	-	-	-
HMBIOMIE_04375	1.88e-162	-	-	-	UW	ko:K21487,ko:K21489,ko:K21491,ko:K21493	-	ko00000,ko01000,ko02048	nuclease activity
HMBIOMIE_04376	8.91e-121	-	-	-	S	ko:K21490	-	ko00000,ko02048	SMI1 / KNR4 family (SUKH-1)
HMBIOMIE_04377	7.01e-129	yokK	-	-	S	-	-	-	SMI1 / KNR4 family
HMBIOMIE_04378	1.06e-127	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
HMBIOMIE_04381	1.36e-53	-	-	-	-	-	-	-	-
HMBIOMIE_04382	6.95e-145	-	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HMBIOMIE_04383	1.4e-65	-	-	-	S	-	-	-	DNA primase activity
HMBIOMIE_04384	1.47e-69	-	-	-	L	-	-	-	Participates in initiation and elongation during chromosome replication
HMBIOMIE_04385	5.75e-35	-	-	-	S	-	-	-	Bacillus cereus group antimicrobial protein
HMBIOMIE_04386	8.02e-15	-	-	-	S	-	-	-	YopX protein
HMBIOMIE_04388	4.53e-43	-	-	-	S	-	-	-	YopX protein
HMBIOMIE_04389	3.08e-89	-	-	-	S	-	-	-	Protein of unknown function (DUF1273)
HMBIOMIE_04393	3.7e-15	-	-	-	S	-	-	-	Protein of unknown function (DUF2815)
HMBIOMIE_04396	2.12e-175	-	-	-	S	ko:K07741	-	ko00000	Phage regulatory protein Rha (Phage_pRha)
HMBIOMIE_04398	1.77e-50	-	-	-	-	-	-	-	-