ORF_ID e_value Gene_name EC_number CAZy COGs KEGG_ko KEGG_Pathway BRITE Description
MANCPEPA_00001 0.0 ybaR - - P ko:K03321 - ko00000,ko02000 COG0659 Sulfate permease and related transporters (MFS superfamily)
MANCPEPA_00002 3.47e-205 ybaS - - S - - - Na -dependent transporter
MANCPEPA_00003 4.01e-184 ybbA - - S ko:K07017 - ko00000 Putative esterase
MANCPEPA_00004 4.99e-228 feuC - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_00005 2.88e-226 feuB - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_00006 7.58e-218 feuA - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Iron-uptake system-binding protein
MANCPEPA_00007 0.0 ybbB - - K ko:K21701 - ko00000,ko03000 COG2207 AraC-type DNA-binding domain-containing proteins
MANCPEPA_00008 2.84e-303 ybbC - - S - - - protein conserved in bacteria
MANCPEPA_00009 0.0 ybbD 3.2.1.52 - G ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 ko00000,ko00001,ko00002,ko01000 Belongs to the glycosyl hydrolase 3 family
MANCPEPA_00010 4.23e-284 ybbE 3.4.16.4 - V ko:K21469 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Belongs to the UPF0214 family
MANCPEPA_00011 2.97e-303 ybbF 2.7.1.211 - G ko:K02808,ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_00012 1.28e-192 ybbH - - K - - - transcriptional
MANCPEPA_00013 1.64e-210 murQ 4.2.1.126 - G ko:K07106 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MANCPEPA_00014 1.81e-113 ybbJ - - J - - - acetyltransferase
MANCPEPA_00015 4.19e-101 ybbK - - S - - - Protein of unknown function (DUF523)
MANCPEPA_00021 9.27e-127 sigW - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_00022 3.19e-151 rsiW - - K - - - Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
MANCPEPA_00023 5.43e-189 dacA 2.7.7.85 - S ko:K18672 - ko00000,ko01000 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MANCPEPA_00024 3.41e-291 ybbR - - S - - - protein conserved in bacteria
MANCPEPA_00025 0.0 glmM 5.4.2.10 - G ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 ko00000,ko00001,ko01000 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MANCPEPA_00026 0.0 glmS 2.6.1.16 - M ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 ko00000,ko00001,ko01000,ko01002 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MANCPEPA_00027 5.38e-220 alkA 3.2.2.21 - L ko:K01247,ko:K13529 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MANCPEPA_00028 1.71e-152 adaA - - K ko:K13530 - ko00000,ko01000,ko03000,ko03400 Transcriptional regulator
MANCPEPA_00029 1.06e-128 adaB 2.1.1.63 - L ko:K00567,ko:K10778,ko:K13531 - ko00000,ko01000,ko03000,ko03400 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MANCPEPA_00030 0.0 ndhF 1.6.5.3 - CP ko:K05577 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MANCPEPA_00031 0.0 ybcC - - S ko:K09822 - ko00000 Belongs to the UPF0753 family
MANCPEPA_00032 3.29e-121 ybcF - - P - - - carbonic anhydrase
MANCPEPA_00033 4.6e-63 - - - - - - - -
MANCPEPA_00034 3.6e-80 ybcI - - S - - - Uncharacterized conserved protein (DUF2294)
MANCPEPA_00035 9.45e-67 - - - K - - - Helix-turn-helix domain
MANCPEPA_00036 9.37e-258 ybcL - - EGP ko:K08164 - ko00000,ko02000 COG2814 Arabinose efflux permease
MANCPEPA_00037 4.61e-72 - - - - - - - -
MANCPEPA_00038 2.31e-232 - - - S - - - hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MANCPEPA_00039 3.28e-156 - - - T ko:K02483 - ko00000,ko02022 Transcriptional regulatory protein, C terminal
MANCPEPA_00040 1.61e-218 - - - T - - - His Kinase A (phospho-acceptor) domain
MANCPEPA_00042 3.26e-177 ybdM 2.7.11.1 - KLT ko:K08884 - ko00000,ko01000,ko01001 Protein tyrosine kinase
MANCPEPA_00043 7.4e-193 ybdN - - - - - - -
MANCPEPA_00044 1.49e-272 ybdO - - S - - - Domain of unknown function (DUF4885)
MANCPEPA_00045 0.0 ybxG - - E ko:K03293 - ko00000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_00046 5.46e-51 csgA - - S - - - Sigma-G-dependent sporulation-specific SASP protein
MANCPEPA_00047 6.92e-41 ybxH - - S - - - Family of unknown function (DUF5370)
MANCPEPA_00048 1.29e-193 ybxI 3.5.2.6 - V ko:K17838 ko01501,map01501 ko00000,ko00001,ko01000 beta-lactamase
MANCPEPA_00049 1.09e-313 cypC 1.11.2.4 - Q ko:K15629 - ko00000,ko00199,ko01000 Cytochrome P450
MANCPEPA_00050 1.11e-54 ybyB - - - - - - -
MANCPEPA_00051 0.0 ybeC - - E - - - amino acid
MANCPEPA_00052 1.09e-54 - - - M - - - PFAM Glycosyl transferase family 2
MANCPEPA_00053 3.32e-205 glpQ 3.1.3.1, 3.1.4.46 - C ko:K01113,ko:K01126 ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020 ko00000,ko00001,ko00002,ko01000 glycerophosphoryl diester phosphodiesterase
MANCPEPA_00054 0.0 glpT - - G ko:K02445 - ko00000,ko02000 -transporter
MANCPEPA_00055 3.57e-47 - - - S - - - Protein of unknown function (DUF2651)
MANCPEPA_00056 2.1e-218 ybfA - - K - - - FR47-like protein
MANCPEPA_00057 1.94e-286 ybfB - - G - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_00059 0.0 ybfG - - M - - - Domain of unknown function (DUF1906)
MANCPEPA_00060 5.27e-208 ybfH - - EG - - - EamA-like transporter family
MANCPEPA_00061 7.39e-188 ybfI - - K - - - AraC-like ligand binding domain
MANCPEPA_00062 6.53e-271 purT 2.1.2.2 - F ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MANCPEPA_00063 1.44e-229 mpr - - M - - - Belongs to the peptidase S1B family
MANCPEPA_00065 7.9e-214 - - - S - - - Alpha/beta hydrolase family
MANCPEPA_00066 5.67e-123 pssA 2.7.8.8 - I ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MANCPEPA_00067 7.07e-112 ybfM - - S - - - SNARE associated Golgi protein
MANCPEPA_00068 2.06e-188 psd 4.1.1.65 - I ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
MANCPEPA_00069 1.35e-60 ybfN - - - - - - -
MANCPEPA_00070 0.0 - - - S ko:K06880 - ko00000,ko01000,ko01504 Erythromycin esterase
MANCPEPA_00071 1.16e-244 ybfQ - - S ko:K07146 - ko00000 Belongs to the UPF0176 family
MANCPEPA_00072 4.25e-273 gltP - - C ko:K11102 - ko00000,ko02000 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MANCPEPA_00073 0.0 ptsG 2.7.1.199 - G ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_00074 1.43e-172 nagB 3.5.99.6 - G ko:K02564 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MANCPEPA_00075 2.91e-165 - - - K ko:K03710,ko:K10711 - ko00000,ko03000 UTRA
MANCPEPA_00077 3.08e-259 ilvE 2.6.1.42 - E ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 Branched-chain amino acid aminotransferase
MANCPEPA_00078 0.0 ybgF - - E ko:K02205,ko:K03293,ko:K16235,ko:K16236 - ko00000,ko02000 amino acid
MANCPEPA_00079 9.76e-229 mmuM 2.1.1.10 - H ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 ko00000,ko00001,ko01000 homocysteine
MANCPEPA_00080 0.0 agcS - - E ko:K03310,ko:K11626 ko02020,map02020 ko00000,ko00001 Sodium alanine symporter
MANCPEPA_00081 2.16e-238 glsA 3.5.1.2 - E ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 ko00000,ko00001,ko01000 Belongs to the glutaminase family
MANCPEPA_00082 3.55e-294 glnJ 2.7.13.3 - T ko:K07717 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_00083 1.72e-217 glnL - - T ko:K07719 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 Regulator
MANCPEPA_00084 4.1e-222 ycbC 4.2.1.41 - EM ko:K01707 ko00053,ko01100,map00053,map01100 ko00000,ko00001,ko01000 5-dehydro-4-deoxyglucarate dehydratase activity
MANCPEPA_00085 2.2e-161 ycbD - - C ko:K22187 ko00040,map00040 ko00000,ko00001,ko01000 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MANCPEPA_00086 3.08e-214 ycbM - - T - - - Histidine kinase
MANCPEPA_00087 4.56e-214 - - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00088 3.34e-147 - - - S - - - ABC-2 family transporter protein
MANCPEPA_00089 5.22e-75 ycbP - - S - - - Protein of unknown function (DUF2512)
MANCPEPA_00090 5.22e-102 cwlJ 3.5.1.28 - M ko:K01449 - ko00000,ko01000 Cell wall
MANCPEPA_00091 1.56e-173 ycbR - - T - - - vWA found in TerF C terminus
MANCPEPA_00092 0.0 phoD 3.1.3.1 - P ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 ko00000,ko00001,ko00002,ko01000 COG3540 Phosphodiesterase alkaline phosphatase D
MANCPEPA_00093 3.12e-38 tatAD - - U ko:K03116 ko03060,ko03070,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MANCPEPA_00094 3.61e-158 tatC - - U ko:K03118 ko03060,ko03070,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MANCPEPA_00095 1.99e-153 pcp 3.4.19.3 - O ko:K01304 - ko00000,ko01000,ko01002 Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MANCPEPA_00096 1.45e-260 ycbU - - E - - - Selenocysteine lyase
MANCPEPA_00097 2.05e-301 lmrB - - EGP ko:K18926 - ko00000,ko00002,ko02000 the major facilitator superfamily
MANCPEPA_00098 8.57e-128 lmrA - - K ko:K18939 - ko00000,ko00002,ko03000 Transcriptional regulator
MANCPEPA_00099 1.76e-259 ansB 3.5.1.1 - EJ ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 ko00000,ko00001,ko01000 COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
MANCPEPA_00100 4e-147 - 3.1.1.3 - S ko:K01046 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko00002,ko01000 acetyltransferases and hydrolases with the alpha beta hydrolase fold
MANCPEPA_00101 1.14e-73 - - - S - - - RDD family
MANCPEPA_00102 2.49e-255 yccF - - K ko:K07039 - ko00000 SEC-C motif
MANCPEPA_00103 2.3e-208 natK 2.7.13.3 - T ko:K11640 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 GHKL domain
MANCPEPA_00104 6.86e-163 natR - - T ko:K02477,ko:K11641 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 LytTr DNA-binding domain
MANCPEPA_00105 2.2e-170 natA 3.6.3.7 - CP ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 ko00000,ko00001,ko00002,ko01000,ko02000 ATPases associated with a variety of cellular activities
MANCPEPA_00106 5.64e-257 - - - CP ko:K09696 ko02010,ko02020,map02010,map02020 ko00000,ko00001,ko00002,ko02000 ABC-2 family transporter protein
MANCPEPA_00107 5.59e-221 yccK - - C - - - Aldo keto reductase
MANCPEPA_00108 1.35e-241 ycdA - - S - - - Domain of unknown function (DUF5105)
MANCPEPA_00109 0.0 ycdB - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_00110 0.0 ycdC - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_00111 3.91e-125 - - - M ko:K17733 - ko00000,ko01000,ko01002,ko01011 D-alanyl-D-alanine carboxypeptidase
MANCPEPA_00112 1.42e-248 rapJ - - S ko:K06368 - ko00000,ko01000 Response regulator aspartate phosphatase
MANCPEPA_00113 2.39e-180 - 1.1.1.47 - IQ ko:K00034 ko00030,ko01120,ko01200,map00030,map01120,map01200 ko00000,ko00001,ko01000 Enoyl-(Acyl carrier protein) reductase
MANCPEPA_00114 0.0 malL 3.2.1.10, 3.2.1.20 GH13,GH31 G ko:K01182,ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 ko00000,ko00001,ko01000 COG0366 Glycosidases
MANCPEPA_00115 1.95e-221 adcA - - P ko:K09815 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the bacterial solute-binding protein 9 family
MANCPEPA_00116 1.99e-170 adcC - - P ko:K02074,ko:K09817 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MANCPEPA_00117 4.63e-173 adcB - - P ko:K09816 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MANCPEPA_00118 4.19e-238 yceB - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_00119 3.75e-141 yceC 3.5.4.33 - T ko:K11991 - ko00000,ko01000,ko03016 proteins involved in stress response, homologs of TerZ and
MANCPEPA_00120 8.9e-137 yceD - - T ko:K05795 - ko00000 proteins involved in stress response, homologs of TerZ and
MANCPEPA_00121 1e-137 yceE - - T ko:K05795 - ko00000 proteins involved in stress response, homologs of TerZ and
MANCPEPA_00122 1.18e-175 yceF - - P ko:K05794 - ko00000 Protein of unknown function (DUF475)
MANCPEPA_00123 0.0 yceG - - S - - - Putative component of 'biosynthetic module'
MANCPEPA_00124 2.96e-245 yceH - - P - - - Belongs to the TelA family
MANCPEPA_00125 1.9e-278 yceI - - P ko:K08369 - ko00000,ko02000 Uncharacterised MFS-type transporter YbfB
MANCPEPA_00126 1.42e-204 - - - EGP - - - Uncharacterised MFS-type transporter YbfB
MANCPEPA_00127 4.82e-61 - - - K - - - helix_turn_helix, Arsenical Resistance Operon Repressor
MANCPEPA_00128 8.99e-293 opuAA 3.6.3.32 - E ko:K02000 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 glycine betaine
MANCPEPA_00129 2.1e-186 opuAB - - P ko:K02001 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 glycine betaine
MANCPEPA_00130 1.16e-209 opuAC - - E ko:K02001,ko:K02002 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 glycine betaine
MANCPEPA_00131 6.87e-277 amhX - - S ko:K14665 - ko00000,ko01000,ko01002 amidohydrolase
MANCPEPA_00132 0.0 ycgA - - S - - - Membrane
MANCPEPA_00133 1.25e-127 ycgB - - - - - - -
MANCPEPA_00134 0.0 amyE 3.2.1.1 GH13 G ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 ko00000,ko00001,ko01000 alpha-amylase
MANCPEPA_00135 2.06e-233 ldh 1.1.1.27 - C ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 ko00000,ko00001,ko01000,ko04147 Belongs to the LDH MDH superfamily. LDH family
MANCPEPA_00136 0.0 lctP - - C ko:K03303 - ko00000,ko02000 L-lactate permease
MANCPEPA_00137 0.0 mdr - - EGP - - - the major facilitator superfamily
MANCPEPA_00138 3.7e-101 ycgE - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_00139 6.42e-147 ycgF - - E - - - Lysine exporter protein LysE YggA
MANCPEPA_00140 1.85e-195 yqcI - - S ko:K09190 - ko00000 YqcI/YcgG family
MANCPEPA_00141 0.0 ycgH - - E ko:K03293 - ko00000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_00142 7.6e-145 ycgI - - S ko:K09967 - ko00000 Domain of unknown function (DUF1989)
MANCPEPA_00143 1.83e-191 nadE 6.3.1.5 - H ko:K01916 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MANCPEPA_00144 3.09e-139 tmrB - - S - - - AAA domain
MANCPEPA_00146 1.05e-136 aroK 2.7.1.71 - F ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MANCPEPA_00147 1.51e-185 - - - Q - - - ubiE/COQ5 methyltransferase family
MANCPEPA_00148 1.81e-224 ycgK - - K ko:K04761 ko02026,map02026 ko00000,ko00001,ko03000 LysR substrate binding domain
MANCPEPA_00149 1.1e-231 cah 3.1.1.41 - Q ko:K01060 ko00311,ko01130,map00311,map01130 ko00000,ko00001,ko01000 Acetyl xylan esterase (AXE1)
MANCPEPA_00150 3.69e-185 ycgL - - S ko:K07074 - ko00000 Predicted nucleotidyltransferase
MANCPEPA_00151 3.63e-218 ycgM - - E ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 ko00000,ko00001,ko01000 Proline dehydrogenase
MANCPEPA_00152 0.0 rocA 1.2.1.88 - C ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 ko00000,ko00001,ko01000 Belongs to the aldehyde dehydrogenase family. RocA subfamily
MANCPEPA_00153 2.64e-316 putP - - E ko:K11928 - ko00000,ko02000 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANCPEPA_00154 3.92e-288 ycgP - - QT - - - COG2508 Regulator of polyketide synthase expression
MANCPEPA_00155 7.4e-193 ycgQ - - S ko:K08986 - ko00000 membrane
MANCPEPA_00156 1.3e-186 ycgR - - S ko:K07089 - ko00000 permeases
MANCPEPA_00157 7.55e-206 ycgS - - I - - - alpha/beta hydrolase fold
MANCPEPA_00158 3.33e-242 ycgT 1.18.1.2, 1.19.1.1 - C ko:K21567 - ko00000,ko01000 Ferredoxin--NADP reductase
MANCPEPA_00159 0.0 nasF 2.1.1.107, 4.2.1.75 - H ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the precorrin methyltransferase family
MANCPEPA_00160 1.2e-74 nasE 1.7.1.15 - P ko:K00363 ko00910,ko01120,map00910,map01120 ko00000,ko00001,ko00002,ko01000 Nitrite reductase
MANCPEPA_00161 0.0 nasD 1.7.1.15 - C ko:K00362 ko00910,ko01120,map00910,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MANCPEPA_00162 0.0 nasC - - C ko:K00372 ko00910,ko01120,map00910,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MANCPEPA_00163 0.0 nasB 1.7.1.15 - C ko:K00362 ko00910,ko01120,map00910,map01120 ko00000,ko00001,ko00002,ko01000 Assimilatory nitrate reductase (electron transfer subunit)
MANCPEPA_00164 3.18e-282 nasA - - P ko:K02575 ko00910,map00910 ko00000,ko00001,ko00002,ko02000 COG2223 Nitrate nitrite transporter
MANCPEPA_00165 1.31e-216 folE2 3.5.4.16 - S ko:K09007 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 Converts GTP to 7,8-dihydroneopterin triphosphate
MANCPEPA_00166 9.38e-132 - - - M - - - ErfK YbiS YcfS YnhG
MANCPEPA_00167 1.94e-290 yciC - - S - - - GTPases (G3E family)
MANCPEPA_00168 2.99e-149 yckA - - P ko:K10009 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0765 ABC-type amino acid transport system, permease component
MANCPEPA_00169 7.26e-185 yckB - - ET ko:K02030,ko:K02424 ko02010,map02010 ko00000,ko00001,ko00002,ko02000,ko02035 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
MANCPEPA_00170 1.01e-68 yckD - - S - - - Protein of unknown function (DUF2680)
MANCPEPA_00171 0.0 yckE 3.2.1.21, 3.2.1.86 GT1 G ko:K01223,ko:K05350 ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 1 family
MANCPEPA_00172 3.36e-91 nin - - S - - - Competence protein J (ComJ)
MANCPEPA_00173 2.77e-100 nucA - - M - - - Deoxyribonuclease NucA/NucB
MANCPEPA_00174 6.52e-269 tlpC - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_00175 1.38e-127 hxlB 5.3.1.27 - G ko:K08094 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 ko00000,ko00001,ko00002,ko01000 SIS domain
MANCPEPA_00176 2.39e-138 hxlA 4.1.2.43 - G ko:K08093 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 ko00000,ko00001,ko00002,ko01000 3-hexulose-6-phosphate synthase
MANCPEPA_00177 6.05e-86 hxlR - - K - - - transcriptional
MANCPEPA_00178 0.0 srfAA - - Q ko:K15654,ko:K15655,ko:K16119 ko01054,ko02024,map01054,map02024 ko00000,ko00001,ko01008 Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_00179 0.0 srfAB - - Q ko:K15654,ko:K15655,ko:K16120 ko01054,ko02024,map01054,map02024 ko00000,ko00001,ko01008 Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_00180 0.0 srfAC - - Q ko:K15656,ko:K16121 ko01054,ko02024,map01054,map02024 ko00000,ko00001,ko01008 COG1020 Non-ribosomal peptide synthetase modules and related proteins
MANCPEPA_00181 1.63e-179 srfAD - - Q ko:K15657 ko02024,map02024 ko00000,ko00001,ko01008 thioesterase
MANCPEPA_00182 2.18e-288 - - - EGP - - - Major Facilitator Superfamily
MANCPEPA_00183 1.94e-118 - - - S - - - YcxB-like protein
MANCPEPA_00184 6.59e-205 ycxC - - EG - - - EamA-like transporter family
MANCPEPA_00185 1.28e-299 ycxD - - K - - - GntR family transcriptional regulator
MANCPEPA_00186 2.02e-146 sfp - - H ko:K06133 ko00770,map00770 ko00000,ko00001,ko01000 Belongs to the P-Pant transferase superfamily
MANCPEPA_00187 8.71e-148 yczE - - S ko:K07149 - ko00000 membrane
MANCPEPA_00188 3.38e-170 tcyC - - E ko:K10010 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1126 ABC-type polar amino acid transport system, ATPase component
MANCPEPA_00189 4.6e-157 tcyB - - P ko:K10009 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0765 ABC-type amino acid transport system, permease component
MANCPEPA_00190 3.03e-188 tcyA - - ET ko:K02424 ko02010,map02010 ko00000,ko00001,ko00002,ko02000,ko02035 Belongs to the bacterial solute-binding protein 3 family
MANCPEPA_00191 5.32e-209 yclA - - K ko:K21755 - ko00000,ko03000 LysR substrate binding domain
MANCPEPA_00192 1.35e-141 ubiX 2.5.1.129 - H ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 ko00000,ko00001,ko00002,ko01000 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
MANCPEPA_00193 0.0 yclC 4.1.1.61, 4.1.1.98 - H ko:K01612,ko:K03182,ko:K16874 ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map01100,map01110,map01120,map01220 ko00000,ko00001,ko00002,ko01000 Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
MANCPEPA_00194 9.86e-53 - 4.1.1.61 - S ko:K21759 ko00627,ko01120,ko01220,map00627,map01120,map01220 ko00000,ko00001,ko01000 response to toxic substance
MANCPEPA_00195 2.32e-104 yclD - - - - - - -
MANCPEPA_00196 1.16e-203 yclE 3.4.11.5 - S ko:K01259 ko00330,map00330 ko00000,ko00001,ko01000,ko01002 Alpha beta hydrolase
MANCPEPA_00197 0.0 dtpT - - E ko:K03305 - ko00000 amino acid peptide transporter
MANCPEPA_00198 0.0 yclG - - M - - - Pectate lyase superfamily protein
MANCPEPA_00200 0.0 gerKA - - EG ko:K06295,ko:K06307 - ko00000 Spore germination protein
MANCPEPA_00201 8.35e-297 gerKC - - S ko:K06297 - ko00000 spore germination
MANCPEPA_00202 2.29e-254 gerKB - - F ko:K06296 - ko00000,ko02000 Spore germination protein
MANCPEPA_00203 1.18e-155 yclH - - P ko:K02003 - ko00000,ko00002,ko02000 ABC transporter
MANCPEPA_00204 2.64e-278 yclI - - V ko:K02004 - ko00000,ko00002,ko02000 ABC transporter (permease) YclI
MANCPEPA_00205 2.23e-165 yclJ - - T ko:K02483 - ko00000,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_00206 0.0 yclK - - T - - - HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MANCPEPA_00207 2.18e-97 rapA1 - - S ko:K06359,ko:K06361 ko02024,map02024 ko00000,ko00001,ko01000 aspartate phosphatase
MANCPEPA_00209 7.93e-06 - - - S - - - Protein of unknown function (Tiny_TM_bacill)
MANCPEPA_00210 0.0 lysC 2.7.2.4 - E ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the aspartokinase family
MANCPEPA_00211 1.09e-205 yclN - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_00212 3.16e-209 yclO - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_00213 2.29e-175 yclP 3.6.3.34 - P ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00214 3.3e-212 yclQ - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG4607 ABC-type enterochelin transport system, periplasmic component
MANCPEPA_00215 0.0 ycnB - - EGP - - - the major facilitator superfamily
MANCPEPA_00216 5.87e-198 ycnC - - K - - - Transcriptional regulator
MANCPEPA_00217 2.12e-174 - 1.5.1.39 - C ko:K10678,ko:K19286 ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120 ko00000,ko00001,ko01000 Oxidoreductase
MANCPEPA_00218 1.68e-60 ycnE - - S - - - Monooxygenase
MANCPEPA_00219 2.75e-65 yczG - - K - - - helix_turn_helix, Arsenical Resistance Operon Repressor
MANCPEPA_00220 0.0 gabR - - K ko:K00375 - ko00000,ko03000 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_00221 1.97e-312 gabT 2.6.1.19, 2.6.1.22 - E ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 ko00000,ko00001,ko00002,ko01000,ko01007 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MANCPEPA_00222 0.0 gabD 1.2.1.16, 1.2.1.20, 1.2.1.79 - C ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MANCPEPA_00223 1.67e-190 glcU - - U ko:K05340 - ko00000,ko02000 Glucose uptake
MANCPEPA_00224 5.9e-187 gdh 1.1.1.47 - IQ ko:K00034 ko00030,ko01120,ko01200,map00030,map01120,map01200 ko00000,ko00001,ko01000 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_00225 1.07e-138 ycnI - - S - - - protein conserved in bacteria
MANCPEPA_00226 0.0 ycnJ - - P ko:K14166 - ko00000,ko02000 protein, homolog of Cu resistance protein CopC
MANCPEPA_00227 1.22e-137 ycnK - - K ko:K21601 - ko00000,ko03000 COG1349 Transcriptional regulators of sugar metabolism
MANCPEPA_00228 1.34e-74 - - - - - - - -
MANCPEPA_00229 0.0 mtlA 2.7.1.197 - G ko:K02799,ko:K02800 ko00051,ko02060,map00051,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 COG2213 Phosphotransferase system, mannitol-specific IIBC component
MANCPEPA_00230 3.38e-94 mtlF 2.7.1.197 - G ko:K02798 ko00051,ko02060,map00051,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
MANCPEPA_00231 2.97e-266 mtlD 1.1.1.17 - G ko:K00009 ko00051,map00051 ko00000,ko00001,ko01000 COG0246 Mannitol-1-phosphate altronate dehydrogenases
MANCPEPA_00232 1.01e-256 ycsA 1.1.1.83, 1.1.1.93, 4.1.1.73 - CE ko:K07246 ko00630,ko00650,map00630,map00650 ko00000,ko00001,ko01000 Tartrate dehydrogenase
MANCPEPA_00234 6.21e-97 lepB 3.4.21.89 - U ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Belongs to the peptidase S26 family
MANCPEPA_00235 1.41e-142 - - - Q - - - COG0412 Dienelactone hydrolase and related enzymes
MANCPEPA_00236 2.29e-88 ycsD 4.2.1.59 - I ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 FabA-like domain
MANCPEPA_00238 1.1e-176 ycsE 3.1.3.104 - S ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Sucrose-6F-phosphate phosphohydrolase
MANCPEPA_00239 1.1e-180 ycsF - - S ko:K07160 - ko00000 Belongs to the UPF0271 (lamB) family
MANCPEPA_00240 1.32e-271 ycsG - - P - - - COG1914 Mn2 and Fe2 transporters of the NRAMP family
MANCPEPA_00241 8.18e-189 ycsI - - S - - - Belongs to the D-glutamate cyclase family
MANCPEPA_00242 5.04e-173 kipI - - E ko:K06351 - ko00000 Allophanate hydrolase subunit 1
MANCPEPA_00243 1.99e-238 kipA - - E ko:K06350 - ko00000 Allophanate hydrolase subunit 2
MANCPEPA_00244 3.8e-171 kipR - - K - - - Transcriptional regulator
MANCPEPA_00245 4.18e-154 ycsK - - E - - - anatomical structure formation involved in morphogenesis
MANCPEPA_00247 7.67e-66 yczJ - - S - - - biosynthesis
MANCPEPA_00248 0.0 pbpC 3.4.16.4 - M ko:K02545,ko:K21467 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko00002,ko01000,ko01011,ko01504 Penicillin-binding Protein
MANCPEPA_00249 8.6e-220 ycsN - - S - - - Oxidoreductase
MANCPEPA_00250 0.0 mtlR - - K ko:K03483 - ko00000,ko03000 transcriptional regulator, MtlR
MANCPEPA_00251 0.0 ydaB - - IQ - - - acyl-CoA ligase
MANCPEPA_00252 6.78e-126 ydaC - - Q - - - Methyltransferase domain
MANCPEPA_00253 3.74e-207 ydaD - - IQ - - - COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_00254 2.36e-126 ydaE 5.3.1.15 - S ko:K09988 ko00040,map00040 ko00000,ko00001,ko01000 Cupin 2, conserved barrel domain protein
MANCPEPA_00255 2.58e-131 ydaF - - J ko:K03817 - ko00000,ko01000,ko03009 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MANCPEPA_00256 5.24e-101 ydaG - - S - - - general stress protein
MANCPEPA_00257 1.87e-178 amj - - U - - - Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
MANCPEPA_00258 3.12e-61 ydzA - - EGP - - - Domain of unknown function (DUF3817)
MANCPEPA_00259 3.95e-98 lrpC - - K ko:K03719 - ko00000,ko03000,ko03036 Transcriptional regulator
MANCPEPA_00260 0.0 topB 5.99.1.2 - L ko:K03169 - ko00000,ko01000,ko03032 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MANCPEPA_00261 3.45e-264 ydaJ - - M - - - Belongs to the glycosyl hydrolase 8 (cellulase D) family
MANCPEPA_00262 1.33e-194 ydaK - - T - - - Diguanylate cyclase, GGDEF domain
MANCPEPA_00263 3.81e-53 ydaL - - S - - - Uncharacterized protein conserved in bacteria (DUF2334)
MANCPEPA_00264 1.05e-309 ydaL - - S - - - Uncharacterized protein conserved in bacteria (DUF2334)
MANCPEPA_00265 1.93e-304 ydaM - - M - - - Glycosyl transferase family group 2
MANCPEPA_00266 0.0 ydaN - - S - - - Bacterial cellulose synthase subunit
MANCPEPA_00267 0.0 ydaO - - E - - - amino acid
MANCPEPA_00268 1.79e-101 mutT 3.6.1.55 - L ko:K03574 - ko00000,ko01000,ko03400 Belongs to the Nudix hydrolase family
MANCPEPA_00269 0.0 ydaP 1.2.3.3 - EH ko:K00158 ko00620,ko01100,map00620,map01100 ko00000,ko00001,ko01000 Belongs to the TPP enzyme family
MANCPEPA_00270 2.14e-53 - - - - - - - -
MANCPEPA_00271 3.9e-286 mntH - - P ko:K03322 - ko00000,ko02000 H( )-stimulated, divalent metal cation uptake system
MANCPEPA_00272 1.67e-42 ydaS - - S - - - membrane
MANCPEPA_00273 4.7e-97 ydaT - - S - - - Uncharacterized protein conserved in bacteria (DUF2188)
MANCPEPA_00274 2.49e-189 ydbA - - P - - - EcsC protein family
MANCPEPA_00275 3.3e-10 gsiB - - S ko:K06884 - ko00000 general stress protein
MANCPEPA_00276 1.25e-74 ydbB - - G - - - Cupin domain
MANCPEPA_00277 3.53e-80 ydbC - - S - - - Domain of unknown function (DUF4937
MANCPEPA_00278 2.24e-197 ydbD - - P ko:K07217 - ko00000 Catalase
MANCPEPA_00279 3.66e-253 dctB - - G - - - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
MANCPEPA_00280 0.0 dctS 2.7.13.3 - T ko:K11614,ko:K11637,ko:K11691 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Signal transduction histidine kinase regulating citrate malate metabolism
MANCPEPA_00281 3.39e-155 dctR - - T ko:K02475,ko:K11692 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG4565 Response regulator of citrate malate metabolism
MANCPEPA_00282 1.27e-289 dctA - - U ko:K03309,ko:K11102,ko:K11103 ko02020,map02020 ko00000,ko00001,ko02000 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MANCPEPA_00283 4.41e-229 ydbI - - S - - - AI-2E family transporter
MANCPEPA_00284 2.09e-215 ydbJ - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00285 2.99e-159 ydbK - - S ko:K01992 - ko00000,ko00002,ko02000 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MANCPEPA_00286 9.32e-70 ydbL - - - - - - -
MANCPEPA_00287 1.5e-279 ydbM - - I - - - acyl-CoA dehydrogenase
MANCPEPA_00288 1.49e-26 - - - S - - - Fur-regulated basic protein B
MANCPEPA_00290 1.29e-200 yeaB - - P - - - Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MANCPEPA_00291 4.19e-75 ydbP - - CO - - - Thioredoxin
MANCPEPA_00292 3.58e-257 ddl 6.3.2.4 - F ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 ko00000,ko00001,ko01000,ko01011 Belongs to the D-alanine--D-alanine ligase family
MANCPEPA_00293 0.0 murF 6.3.2.10 - M ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 ko00000,ko00001,ko01000,ko01011 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MANCPEPA_00294 0.0 cshA 3.6.4.13 - JKL ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MANCPEPA_00295 2.12e-107 ydbS - - S ko:K09167 - ko00000 Bacterial PH domain
MANCPEPA_00296 0.0 ydbT - - S ko:K08981 - ko00000 Membrane
MANCPEPA_00297 2.53e-139 ydcA - - S - - - membrane protein (homolog of Drosophila rhomboid)
MANCPEPA_00298 1.95e-78 acpS 2.7.8.7 - I ko:K00997 ko00770,map00770 ko00000,ko00001,ko01000 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MANCPEPA_00299 4.66e-234 ydcC - - M - - - COG2834 Outer membrane lipoprotein-sorting protein
MANCPEPA_00300 5.29e-284 alr 5.1.1.1, 5.1.1.5 - E ko:K01775,ko:K20707 ko00473,ko01100,ko01502,map00473,map01100,map01502 ko00000,ko00001,ko01000,ko01011 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MANCPEPA_00301 9.49e-57 ndoAI - - K ko:K07723 - ko00000,ko02048,ko03000 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
MANCPEPA_00302 4.34e-75 ndoA - - L ko:K07171 - ko00000,ko01000,ko02048 Toxic component of a toxin-antitoxin (TA) module
MANCPEPA_00303 8.58e-184 rsbR - - T ko:K17763 - ko00000,ko03021 Positive regulator of sigma-B
MANCPEPA_00304 7.34e-74 rsbS - - T ko:K17762 - ko00000,ko03021 antagonist
MANCPEPA_00305 8.56e-90 rsbT 2.7.11.1 - T ko:K17752 - ko00000,ko01000,ko01001,ko03021 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
MANCPEPA_00306 1.31e-243 rsbU 3.1.3.3 - KT ko:K07315 - ko00000,ko01000,ko03021 phosphatase
MANCPEPA_00307 1.97e-70 rsbV - - T ko:K04749 - ko00000,ko03021 Belongs to the anti-sigma-factor antagonist family
MANCPEPA_00308 2.48e-111 rsbW 2.7.11.1 - F ko:K04757 - ko00000,ko01000,ko01001,ko03021 Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
MANCPEPA_00309 1.55e-178 sigB - - K ko:K03090 - ko00000,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_00310 1.86e-141 rsbX 3.1.3.3 - KT ko:K05518 - ko00000,ko01000,ko03021 Sigma factor PP2C-like phosphatases
MANCPEPA_00311 0.0 tex - - K ko:K06959 - ko00000 COG2183 Transcriptional accessory protein
MANCPEPA_00312 3.74e-108 ydcK - - S ko:K03095 - ko00000 Belongs to the SprT family
MANCPEPA_00320 8.04e-96 - - - J - - - Acetyltransferase (GNAT) domain
MANCPEPA_00321 2.85e-58 - - - - - - - -
MANCPEPA_00322 6.13e-176 - - - L ko:K21487 - ko00000,ko01000,ko02048 A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MANCPEPA_00323 1.8e-45 - - - K ko:K07729 - ko00000,ko03000 Helix-turn-helix XRE-family like proteins
MANCPEPA_00324 1.21e-52 - - - - - - - -
MANCPEPA_00325 1.07e-241 des 1.14.19.23, 1.14.19.45 - I ko:K10255 ko02020,map02020 ko00000,ko00001,ko01000,ko01004 fatty acid desaturase
MANCPEPA_00326 4.22e-41 cspL - - K ko:K03704 - ko00000,ko03000 Cold shock
MANCPEPA_00327 1.45e-102 ydeB - - K ko:K07736 - ko00000,ko03000 Transcription factor
MANCPEPA_00328 6.87e-182 gmT1 - - EG - - - COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MANCPEPA_00329 1.31e-210 - - - K - - - AraC-like ligand binding domain
MANCPEPA_00330 3.23e-220 ydeD - - EG - - - COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MANCPEPA_00331 1.12e-210 ydeE - - K ko:K13653 - ko00000,ko03000 AraC family transcriptional regulator
MANCPEPA_00332 0.0 - - - K - - - COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_00333 1.88e-277 ydeG - - EGP - - - Major facilitator superfamily
MANCPEPA_00334 9.2e-70 ydeH - - - - - - -
MANCPEPA_00335 2.25e-132 ydeI - - S - - - Bacteriocin-protection, YdeI or OmpD-Associated
MANCPEPA_00336 8.72e-133 - - - - - - - -
MANCPEPA_00337 3.3e-19 ptsH - - G ko:K11189 - ko00000,ko02000 PTS HPr component phosphorylation site
MANCPEPA_00338 2.44e-110 - - - K - - - Transcriptional regulator C-terminal region
MANCPEPA_00339 6.34e-195 ydeK - - EG - - - -transporter
MANCPEPA_00340 0.0 ydeL - - K ko:K00375 - ko00000,ko03000 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_00341 1.06e-96 ydeM1 - - I - - - N-terminal half of MaoC dehydratase
MANCPEPA_00342 1.39e-134 - - - S ko:K07002 - ko00000 Serine hydrolase
MANCPEPA_00343 2.49e-73 - - - K - - - HxlR-like helix-turn-helix
MANCPEPA_00344 7.99e-195 ydeO - - S - - - Uncharacterized protein conserved in bacteria (DUF2179)
MANCPEPA_00345 2.09e-252 ydeR - - EGP - - - Uncharacterised MFS-type transporter YbfB
MANCPEPA_00346 2.16e-135 ydeS - - K - - - Transcriptional regulator
MANCPEPA_00347 1.05e-75 arsR - - K ko:K03892,ko:K22043 - ko00000,ko03000 transcriptional
MANCPEPA_00348 9.07e-297 arsB - - P ko:K03893 - ko00000,ko02000 Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MANCPEPA_00349 1.01e-184 - - - J - - - GNAT acetyltransferase
MANCPEPA_00350 2.3e-202 - - - EG - - - EamA-like transporter family
MANCPEPA_00351 0.0 ydfD - - K ko:K18907 - ko00000,ko00002,ko01504,ko03000 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_00352 4.04e-149 ydfE - - S - - - Flavin reductase like domain
MANCPEPA_00353 1.23e-157 ydfF - - K - - - helix_turn_helix, Arsenical Resistance Operon Repressor
MANCPEPA_00354 3.92e-104 - - - S - - - Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MANCPEPA_00355 2.77e-251 ydfH 2.7.13.3 - T ko:K11623 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_00356 2.3e-142 ydfI - - K ko:K11624 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_00357 0.0 ydfJ - - S ko:K06994,ko:K11625 ko02020,map02020 ko00000,ko00001 drug exporters of the RND superfamily
MANCPEPA_00358 3.8e-223 - - - S - - - Alpha/beta hydrolase family
MANCPEPA_00359 2.27e-150 - - - S ko:K07150 - ko00000 Protein of unknown function (DUF554)
MANCPEPA_00360 9.11e-72 - - - K - - - Bacterial transcription activator, effector binding domain
MANCPEPA_00361 6.75e-83 - - - K - - - Bacterial transcription activator, effector binding domain
MANCPEPA_00362 2.12e-198 ydfM - - P - - - Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MANCPEPA_00363 6.68e-143 ydfN - - C ko:K15976 - ko00000,ko01000 nitroreductase
MANCPEPA_00364 2.61e-236 ydfO - - E ko:K15975 - ko00000 COG0346 Lactoylglutathione lyase and related lyases
MANCPEPA_00365 8.02e-84 ydfP - - S ko:K15977 - ko00000 DoxX
MANCPEPA_00366 3.78e-74 ydfQ - - CO - - - Thioredoxin
MANCPEPA_00367 2.4e-21 ydgA - - S - - - Spore germination protein gerPA/gerPF
MANCPEPA_00368 5.33e-39 - - - - - - - -
MANCPEPA_00370 6.08e-153 ydfR - - S - - - Protein of unknown function (DUF421)
MANCPEPA_00371 8.96e-160 ydfS - - S - - - Protein of unknown function (DUF421)
MANCPEPA_00372 3.13e-99 cotP - - O ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Belongs to the small heat shock protein (HSP20) family
MANCPEPA_00373 2.74e-50 ydgA - - S - - - Spore germination protein gerPA/gerPF
MANCPEPA_00374 2.19e-56 ydgB - - S - - - Spore germination protein gerPA/gerPF
MANCPEPA_00375 4.04e-126 ydgC - - K - - - Bacterial regulatory proteins, tetR family
MANCPEPA_00376 1.93e-68 - - - S - - - DoxX-like family
MANCPEPA_00377 2.46e-68 yycN - - K - - - Acetyltransferase
MANCPEPA_00378 0.0 expZ - - S ko:K18231 ko02010,map02010 br01600,ko00000,ko00001,ko01504,ko02000 ABC transporter
MANCPEPA_00379 0.0 aapA - - E ko:K03293,ko:K11737 - ko00000,ko02000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_00380 1.2e-117 - - - S - - - DinB family
MANCPEPA_00381 2.92e-104 - - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_00382 0.0 ydgH - - S ko:K06994 - ko00000 drug exporters of the RND superfamily
MANCPEPA_00383 1.51e-145 ydgI - - C - - - nitroreductase
MANCPEPA_00384 1.9e-89 - - - K - - - Winged helix DNA-binding domain
MANCPEPA_00385 9.89e-266 tcaB - - EGP ko:K07552 - ko00000,ko02000 -transporter
MANCPEPA_00386 7.2e-155 ydhB - - S ko:K07090 - ko00000 membrane transporter protein
MANCPEPA_00387 5.24e-158 ydhC - - K - - - FCD
MANCPEPA_00388 4.24e-308 ydhD - - M - - - Glycosyl hydrolase
MANCPEPA_00389 1.94e-289 ydhE - - CG - - - COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MANCPEPA_00390 3.52e-162 - - - - - - - -
MANCPEPA_00391 0.0 phoB 3.1.3.1 - P ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Belongs to the alkaline phosphatase family
MANCPEPA_00392 3.33e-89 frataxin - - S ko:K05937 - ko00000 Domain of unknown function (DU1801)
MANCPEPA_00394 3.25e-109 - - - K - - - Acetyltransferase (GNAT) domain
MANCPEPA_00395 7.41e-229 ydhJ - - S ko:K06885 - ko00000 Metal dependent phosphohydrolases with conserved 'HD' motif.
MANCPEPA_00396 3.29e-127 ydhK - - M - - - Protein of unknown function (DUF1541)
MANCPEPA_00397 2.56e-254 ydhL - - EGP ko:K18567 - ko00000,ko02000 COG2814 Arabinose efflux permease
MANCPEPA_00398 2.29e-64 ydhM 2.7.1.196, 2.7.1.205 - G ko:K02760 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_00399 1.44e-68 ydhN3 2.7.1.196, 2.7.1.205 - G ko:K02759 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_00400 7.59e-304 celB - - G ko:K02761 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko02000 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MANCPEPA_00401 0.0 ydhP 3.2.1.21, 3.2.1.86 GT1 G ko:K01223,ko:K05350 ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 1 family
MANCPEPA_00402 7.75e-171 ydhQ - - K ko:K03492 - ko00000,ko03000 UTRA
MANCPEPA_00403 7.86e-211 gmuE 2.7.1.4 - GK ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko00000,ko00001,ko01000 COG1940 Transcriptional regulator sugar kinase
MANCPEPA_00404 1.46e-239 manA 5.3.1.8 - G ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 mannose-6-phosphate isomerase
MANCPEPA_00405 2.64e-268 ydhT1 3.2.1.78 GH26 G ko:K01218 ko00051,ko02024,map00051,map02024 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 26 family
MANCPEPA_00406 4.02e-201 ydhU - - P ko:K07217 - ko00000 Catalase
MANCPEPA_00430 0.0 glgB 2.4.1.18 CBM48,GH13 G ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MANCPEPA_00431 8.49e-265 glgC 2.7.7.27 - G ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 ko00000,ko00001,ko00002,ko01000 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MANCPEPA_00432 6.43e-239 glgD 2.7.7.27 - G ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 ko00000,ko00001,ko00002,ko01000 Glucose-1-phosphate adenylyltransferase, GlgD subunit
MANCPEPA_00433 0.0 glgA 2.4.1.21 GT5 G ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 ko00000,ko00001,ko00002,ko01000,ko01003 Synthesizes alpha-1,4-glucan chains using ADP-glucose
MANCPEPA_00434 0.0 glgP 2.4.1.1 GT35 G ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 ko00000,ko00001,ko01000 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
MANCPEPA_00435 1.97e-101 ytaB - - T ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 ko00000,ko00001,ko02000 membrane
MANCPEPA_00436 1.06e-259 cotI - - S ko:K06331 - ko00000 Spore coat protein
MANCPEPA_00437 1.75e-276 cotSA - - M ko:K06338 - ko00000 Glycosyl transferases group 1
MANCPEPA_00438 1.7e-263 cotS - - S ko:K06337 - ko00000 Seems to be required for the assembly of the CotSA protein in spores
MANCPEPA_00440 3.04e-299 - - - M ko:K06338 - ko00000 Glycosyltransferase Family 4
MANCPEPA_00441 8.67e-228 ytcB - - M - - - NAD-dependent epimerase dehydratase
MANCPEPA_00442 2.03e-310 ytcA 1.1.1.22 - M ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MANCPEPA_00443 1.34e-193 ytdA 2.7.7.9 - M ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko00000,ko00001,ko00002,ko01000 Nucleotidyl transferase
MANCPEPA_00444 1.75e-168 yteA - - T - - - COG1734 DnaK suppressor protein
MANCPEPA_00445 0.0 menF 5.4.4.2 - HQ ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Isochorismate synthase
MANCPEPA_00446 0.0 menD 2.2.1.9 - H ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MANCPEPA_00447 5.09e-199 menH 4.2.99.20 - S ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
MANCPEPA_00448 3.45e-200 menB 4.1.3.36 - H ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MANCPEPA_00449 0.0 menE 6.2.1.26 - H ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
MANCPEPA_00450 1.17e-271 menC 4.2.1.113 - H ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MANCPEPA_00451 5.35e-217 troA - - P ko:K11707 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the bacterial solute-binding protein 9 family
MANCPEPA_00452 6.58e-174 mntB 3.6.3.35 - P ko:K02074,ko:K09820,ko:K11710,ko:K19973 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MANCPEPA_00453 2.04e-293 mntC - - P ko:K11705,ko:K11708,ko:K19976 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MANCPEPA_00454 7.59e-191 mntD - - P ko:K11709,ko:K19976 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components'
MANCPEPA_00455 2.43e-34 - - - S - - - Domain of Unknown Function (DUF1540)
MANCPEPA_00456 2.08e-241 ythB 1.10.3.14 - C ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 ko00000,ko00001,ko00002,ko01000 COG1294 Cytochrome bd-type quinol oxidase, subunit 2
MANCPEPA_00457 1.03e-315 ythA 1.10.3.14 - C ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 ko00000,ko00001,ko00002,ko01000 oxidase, subunit
MANCPEPA_00458 5.02e-56 rpmE2 - - J ko:K02909 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Ribosomal protein L31
MANCPEPA_00459 8.96e-134 ytiB 4.2.1.1 - P ko:K01673 ko00910,map00910 ko00000,ko00001,ko01000 Reversible hydration of carbon dioxide
MANCPEPA_00460 8.36e-113 luxS 4.4.1.21 - T ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 ko00000,ko00001,ko00002,ko01000 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MANCPEPA_00461 4.78e-95 ytkA - - S - - - YtkA-like
MANCPEPA_00463 1.8e-99 dps - - P ko:K04047 - ko00000,ko03036 Belongs to the Dps family
MANCPEPA_00464 3.2e-81 ytkC - - S - - - Bacteriophage holin family
MANCPEPA_00465 4.47e-113 ytkD 3.6.1.55 - L ko:K03574 - ko00000,ko01000,ko03400 Belongs to the Nudix hydrolase family
MANCPEPA_00466 1.09e-182 ytlD - - P ko:K02050 - ko00000,ko00002,ko02000 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MANCPEPA_00467 1.5e-184 ytlC 3.6.3.36 - P ko:K02049,ko:K10831,ko:K15555 ko00920,ko02010,map00920,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter
MANCPEPA_00468 2.66e-240 ytlA - - P ko:K02051 - ko00000,ko00002,ko02000 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
MANCPEPA_00469 6.67e-191 ytmA - - E - - - COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
MANCPEPA_00470 2.85e-52 ytmB - - S - - - Protein of unknown function (DUF2584)
MANCPEPA_00471 0.0 pckA 4.1.1.49 - C ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MANCPEPA_00472 2.26e-286 metK 2.5.1.6 - H ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MANCPEPA_00473 0.0 asnB 6.3.5.4 - E ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 ko00000,ko00001,ko01000,ko01002 Asparagine synthase
MANCPEPA_00474 0.0 ytnA - - E ko:K03293 - ko00000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_00475 1.68e-87 ytoA - - S - - - COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MANCPEPA_00476 2.33e-192 ytpA 3.1.1.5 - I ko:K01048 ko00564,map00564 ko00000,ko00001,ko01000 Alpha beta hydrolase
MANCPEPA_00477 4.81e-276 ytpB 4.2.3.130 - S ko:K16188 - ko00000,ko01000 Tetraprenyl-beta-curcumene synthase
MANCPEPA_00478 1.86e-134 ytqB - - J - - - Putative rRNA methylase
MANCPEPA_00479 2.35e-244 ytqA - - S ko:K07139 - ko00000 Fe-S oxidoreductase
MANCPEPA_00480 1.27e-55 ytzC - - S - - - Protein of unknown function (DUF2524)
MANCPEPA_00482 2.68e-87 ytrA - - K ko:K07979 - ko00000,ko03000 GntR family transcriptional regulator
MANCPEPA_00483 5.96e-207 ytrB - - P ko:K16921 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00484 5.07e-201 - - - P ko:K16919 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC-2 family transporter protein
MANCPEPA_00485 1.3e-190 - - - - ko:K16919 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 -
MANCPEPA_00486 5.88e-163 ytrE - - V ko:K16920 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00487 5.92e-298 ytrF - - V ko:K02004,ko:K16918 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0577 ABC-type antimicrobial peptide transport system, permease component
MANCPEPA_00488 1.46e-166 graR - - T ko:K11630,ko:K19078 ko01503,ko02020,map01503,map02020 ko00000,ko00001,ko00002,ko01504,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_00489 4.53e-239 bceS 2.7.13.3 - T ko:K11629,ko:K19077 ko01503,ko02020,map01503,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 His Kinase A (phosphoacceptor) domain
MANCPEPA_00490 3.83e-179 bceA - - V ko:K02003,ko:K11631,ko:K19079 ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150 ko00000,ko00001,ko00002,ko01504,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_00491 0.0 bceB - - V ko:K11632,ko:K19080 ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150 ko00000,ko00001,ko00002,ko01504,ko02000 ABC transporter (permease)
MANCPEPA_00492 6.61e-77 yttA - - S - - - Pfam Transposase IS66
MANCPEPA_00493 2.85e-267 yttB - - EGP - - - Major facilitator superfamily
MANCPEPA_00494 5.43e-183 pfyP - - T - - - Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MANCPEPA_00495 3.63e-72 ytvB - - S - - - Protein of unknown function (DUF4257)
MANCPEPA_00496 0.0 leuS 6.1.1.4 - J ko:K01869 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Belongs to the class-I aminoacyl-tRNA synthetase family
MANCPEPA_00497 7.08e-68 ytwF - - P - - - Sulfurtransferase
MANCPEPA_00498 0.0 melA 3.2.1.22 - G ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 ko00000,ko00001,ko01000 Family 4 glycosyl hydrolase
MANCPEPA_00499 7.65e-186 amyC - - P ko:K10119 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter (permease)
MANCPEPA_00500 1.66e-214 amyD - - P ko:K10118 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter
MANCPEPA_00501 2.12e-311 msmE - - G ko:K10117 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Bacterial extracellular solute-binding protein
MANCPEPA_00502 2.17e-242 msmR - - K ko:K02529 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_00503 2.38e-221 - - - S - - - Acetyl xylan esterase (AXE1)
MANCPEPA_00504 2.73e-180 bioW 6.2.1.14 - H ko:K01906 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MANCPEPA_00505 0.0 bioA 2.6.1.105, 2.6.1.62 - H ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko01000,ko01007 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
MANCPEPA_00506 2.21e-276 bioF 2.3.1.29, 2.3.1.47 - H ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 ko00000,ko00001,ko00002,ko01000,ko01007 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MANCPEPA_00507 1.62e-160 bioD 6.3.3.3 - H ko:K01935 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MANCPEPA_00508 2.64e-243 bioB 2.8.1.6 - H ko:K01012 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MANCPEPA_00509 2.83e-282 bioI 1.14.14.46, 1.14.15.13 - C ko:K15468,ko:K16593,ko:K17474 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko00199,ko01000,ko01008 Cytochrome P450
MANCPEPA_00510 1.28e-177 ytbQ 1.1.1.203, 1.1.1.388 - GM ko:K18981,ko:K19243 ko00030,ko00053,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00053,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 NAD dependent epimerase/dehydratase family
MANCPEPA_00511 6.19e-193 ytcP - - G ko:K17320 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0395 ABC-type sugar transport system, permease component
MANCPEPA_00512 0.0 - - - G ko:K17318 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1653 ABC-type sugar transport system, periplasmic component
MANCPEPA_00513 0.0 ytdP - - K - - - Transcriptional regulator
MANCPEPA_00514 2.27e-221 lplB13 - - G ko:K17319 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG4209 ABC-type polysaccharide transport system, permease component
MANCPEPA_00515 1.13e-276 yteR 3.2.1.172 GH105 G ko:K15532 - ko00000,ko01000 unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
MANCPEPA_00516 1.6e-92 yteS - - G - - - transport
MANCPEPA_00517 0.0 yteT - - S - - - Oxidoreductase family, C-terminal alpha/beta domain
MANCPEPA_00518 1.55e-149 yteU - - S - - - Integral membrane protein
MANCPEPA_00519 2.14e-36 yteV - - S - - - Sporulation protein Cse60
MANCPEPA_00520 0.0 opuD - - M ko:K05020 - ko00000,ko02000 Belongs to the BCCT transporter (TC 2.A.15) family
MANCPEPA_00521 4.04e-293 ytfP - - S ko:K07007 - ko00000 HI0933-like protein
MANCPEPA_00522 0.0 ytgP - - S ko:K03328 - ko00000 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_00523 7.43e-170 rsuA 5.4.99.19 - J ko:K06183 - ko00000,ko01000,ko03009 Belongs to the pseudouridine synthase RsuA family
MANCPEPA_00524 4.46e-46 ytzE - - K - - - COG1349 Transcriptional regulators of sugar metabolism
MANCPEPA_00525 3.27e-167 ythP - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter
MANCPEPA_00526 1.86e-250 ythQ - - U ko:K01992 - ko00000,ko00002,ko02000 Bacterial ABC transporter protein EcsB
MANCPEPA_00527 1.73e-288 pbuO - - S ko:K06901 - ko00000,ko02000 permease
MANCPEPA_00528 0.0 ytjP 3.5.1.18 - E ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 ko00000,ko00001,ko00002,ko01000 Dipeptidase
MANCPEPA_00529 3e-221 ytkP 2.5.1.47 - E ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the cysteine synthase cystathionine beta- synthase family
MANCPEPA_00530 1.28e-131 ytlP 3.1.4.58 - J ko:K01975 - ko00000,ko01000,ko03016 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MANCPEPA_00531 4.92e-212 ytlQ - - - - - - -
MANCPEPA_00532 2.22e-231 ytlR - - I - - - Diacylglycerol kinase catalytic domain
MANCPEPA_00533 0.0 amyX 3.2.1.41 CBM48,GH13 G ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 13 family
MANCPEPA_00534 1.75e-191 ytmP - - M - - - Phosphotransferase
MANCPEPA_00535 9.51e-61 ytzH - - S - - - YtzH-like protein
MANCPEPA_00536 7.53e-157 trmB 2.1.1.33 - J ko:K03439 - ko00000,ko01000,ko03016 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MANCPEPA_00537 1.06e-190 ytnP - - S - - - COG0491 Zn-dependent hydrolases, including glyoxylases
MANCPEPA_00538 0.0 malS 1.1.1.38 - C ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 ko00000,ko00001,ko01000 Malate dehydrogenase
MANCPEPA_00539 4.06e-68 ytzB - - S - - - small secreted protein
MANCPEPA_00540 9.11e-262 pepA 3.4.11.7 - G ko:K01261,ko:K01269 - ko00000,ko01000,ko01002 COG1363 Cellulase M and related proteins
MANCPEPA_00541 7.02e-103 ytoQ - - S - - - Nucleoside 2-deoxyribosyltransferase YtoQ
MANCPEPA_00542 3.17e-75 ytpP - - CO - - - Thioredoxin
MANCPEPA_00543 1.02e-191 ytpQ - - S - - - Belongs to the UPF0354 family
MANCPEPA_00544 7.25e-140 ytpR - - J ko:K06878 - ko00000 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MANCPEPA_00545 0.0 sftA - - D ko:K03466 - ko00000,ko03036 Belongs to the FtsK SpoIIIE SftA family
MANCPEPA_00546 0.0 murC 6.3.2.8 - M ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 ko00000,ko00001,ko01000,ko01011 Belongs to the MurCDEF family
MANCPEPA_00547 1.67e-63 ytxG - - S - - - protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MANCPEPA_00548 3.17e-30 ytxH - - S - - - COG4980 Gas vesicle protein
MANCPEPA_00549 1.9e-72 ytxJ - - O - - - Protein of unknown function (DUF2847)
MANCPEPA_00550 7.64e-250 aroA 2.5.1.54, 5.4.99.5 - E ko:K03856,ko:K13853 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
MANCPEPA_00551 4.16e-235 ccpA - - K ko:K02529 - ko00000,ko03000 catabolite control protein A
MANCPEPA_00552 6.84e-187 motP - - N ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 flagellar motor
MANCPEPA_00553 1.6e-161 ytxE - - N ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 Flagellar motor protein
MANCPEPA_00554 3.09e-291 acuC - - BQ ko:K04768 - ko00000 histone deacetylase
MANCPEPA_00555 6.16e-152 acuB - - S ko:K04767 - ko00000 Domain in cystathionine beta-synthase and other proteins.
MANCPEPA_00556 2.84e-155 acuA - - K ko:K04766 - ko00000,ko01000 Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
MANCPEPA_00557 0.0 acsA 6.2.1.1 - I ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000,ko01004 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MANCPEPA_00558 2.52e-301 tyrS 6.1.1.1 - J ko:K01866 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MANCPEPA_00560 2.01e-141 rpsD - - J ko:K02986 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MANCPEPA_00561 0.0 ytrP - - T - - - COG2199 FOG GGDEF domain
MANCPEPA_00562 1.13e-113 ytsP 1.8.4.14 - T ko:K08968 ko00270,map00270 ko00000,ko00001,ko01000 GAF domain-containing protein
MANCPEPA_00563 1.2e-141 yttP - - K - - - Transcriptional regulator
MANCPEPA_00564 1.25e-196 hisK 3.1.3.15 - E ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 COG1387 Histidinol phosphatase and related hydrolases of the PHP family
MANCPEPA_00565 0.0 ezrA - - D ko:K06286 - ko00000,ko03036 modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MANCPEPA_00566 1.17e-304 braB - - E ko:K03311 - ko00000 Component of the transport system for branched-chain amino acids
MANCPEPA_00567 8.21e-268 iscS2 2.8.1.7 - E ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Cysteine desulfurase
MANCPEPA_00568 1.79e-288 thiI 2.8.1.4 - H ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000,ko03016 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MANCPEPA_00569 2.12e-40 - - - S ko:K06418,ko:K06419,ko:K06420 - ko00000 spore protein
MANCPEPA_00570 0.0 ytcI 6.2.1.1 - I ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000,ko01004 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MANCPEPA_00571 0.0 ytcJ - - S - - - amidohydrolase
MANCPEPA_00572 9.78e-189 nadK2 2.7.1.23 - G ko:K00858 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko01000 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MANCPEPA_00573 9.73e-230 sppA - - OU ko:K04773 - ko00000,ko01000,ko01002 signal peptide peptidase SppA
MANCPEPA_00574 4.08e-112 yteJ - - S - - - RDD family
MANCPEPA_00575 1.44e-149 ytfI - - S - - - Protein of unknown function (DUF2953)
MANCPEPA_00576 1.06e-94 ytfJ - - S - - - Sporulation protein YtfJ
MANCPEPA_00577 1.93e-116 tpx 1.11.1.15 - O ko:K11065 - ko00000,ko01000 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MANCPEPA_00578 3.78e-224 ytxK 2.1.1.72 - L ko:K00571 - ko00000,ko01000,ko02048 DNA methylase
MANCPEPA_00579 4.69e-281 ackA 2.7.2.1 - F ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MANCPEPA_00580 9.5e-114 moaB 2.7.7.75 - H ko:K03638 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000 May be involved in the biosynthesis of molybdopterin
MANCPEPA_00581 1.06e-297 argG 6.3.4.5 - E ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the argininosuccinate synthase family. Type 1 subfamily
MANCPEPA_00582 0.0 argH 4.3.2.1 - E ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000,ko04147 argininosuccinate lyase
MANCPEPA_00584 1.98e-182 ytkK 1.1.1.100 - IQ ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_00585 2.71e-166 ytkL - - S - - - Belongs to the UPF0173 family
MANCPEPA_00586 7.09e-223 ytlI - - K ko:K21960 - ko00000,ko03000 LysR substrate binding domain
MANCPEPA_00587 6.63e-127 ytmI - - K ko:K00680 - ko00000,ko01000 Acetyltransferase (GNAT) domain
MANCPEPA_00588 1.76e-192 - - - ET ko:K16956,ko:K16957,ko:K16961 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Bacterial periplasmic substrate-binding proteins
MANCPEPA_00589 2.71e-192 tcyK - - M ko:K16957 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Bacterial periplasmic substrate-binding proteins
MANCPEPA_00590 1.59e-155 ytmL - - P ko:K16958,ko:K16959 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_00591 1.31e-152 - - - U ko:K16959 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_00592 5.43e-182 tcyN - - E ko:K16960 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1126 ABC-type polar amino acid transport system, ATPase component
MANCPEPA_00593 2.06e-235 ytmO - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_00594 5.07e-61 ytnI - - O - - - COG0695 Glutaredoxin and related proteins
MANCPEPA_00595 0.0 ytnJ - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_00596 3.28e-164 - 2.7.1.26, 2.7.7.2 - H ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Riboflavin kinase
MANCPEPA_00597 1.35e-302 hipO2 - - E ko:K01436,ko:K21613 - ko00000,ko01000,ko01002 hydrolase activity
MANCPEPA_00598 1.06e-204 ytnM - - S ko:K07090 - ko00000 membrane transporter protein
MANCPEPA_00599 1.13e-308 ytoI - - K - - - transcriptional regulator containing CBS domains
MANCPEPA_00600 2.15e-63 ytpI - - S - - - YtpI-like protein
MANCPEPA_00601 1.24e-230 nrnA 3.1.13.3, 3.1.3.7 - S ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 ko00000,ko00001,ko01000,ko03400 COG0618 Exopolyphosphatase-related proteins
MANCPEPA_00602 1.15e-39 - - - - - - - -
MANCPEPA_00603 4.21e-111 ytrI - - - - - - -
MANCPEPA_00604 2.45e-75 ytrH - - S - - - Sporulation protein YtrH
MANCPEPA_00605 0.0 dnaE 2.7.7.7 - L ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 DNA polymerase
MANCPEPA_00606 8.53e-287 ytsJ 1.1.1.38 - C ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 ko00000,ko00001,ko01000 Malate dehydrogenase
MANCPEPA_00607 2.17e-208 accD 2.1.3.15, 6.4.1.2 - I ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002,ko01000 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MANCPEPA_00608 9.82e-234 accA 2.1.3.15, 6.4.1.2 - I ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002,ko01000 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MANCPEPA_00609 1.62e-229 pfkA 2.7.1.11 - F ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MANCPEPA_00610 0.0 pyk 2.7.1.40 - G ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Belongs to the pyruvate kinase family
MANCPEPA_00611 4.68e-82 fxsA - - S ko:K07113 - ko00000 COG3030 Protein affecting phage T7 exclusion by the F plasmid
MANCPEPA_00612 2.24e-244 ytvI - - S - - - sporulation integral membrane protein YtvI
MANCPEPA_00613 1.56e-93 ytwI - - S - - - membrane
MANCPEPA_00614 1.17e-267 citZ 2.3.3.1 - C ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Belongs to the citrate synthase family
MANCPEPA_00615 9.27e-309 icd 1.1.1.42 - C ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 br01601,ko00000,ko00001,ko00002,ko01000 isocitrate
MANCPEPA_00616 1.04e-217 mdh 1.1.1.27, 1.1.1.37 - C ko:K00016,ko:K00024 ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the reversible oxidation of malate to oxaloacetate
MANCPEPA_00617 3.52e-166 phoP - - T ko:K07658 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_00618 0.0 phoR 2.7.13.3 - T ko:K07636 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Signal transduction histidine kinase
MANCPEPA_00619 0.0 polA 2.7.7.7 - L ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 ko00000,ko00001,ko01000,ko03032,ko03400 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MANCPEPA_00620 3.88e-200 fpg 3.2.2.23, 4.2.99.18 - L ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MANCPEPA_00621 1.68e-138 ytaF - - P - - - Probably functions as a manganese efflux pump
MANCPEPA_00622 2.82e-126 coaE 2.7.1.24 - F ko:K00859 ko00770,ko01100,map00770,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MANCPEPA_00623 4.54e-205 ytbE - - S - - - reductase
MANCPEPA_00624 3.92e-255 ytbD - - EGP ko:K19577 - ko00000,ko02000 -transporter
MANCPEPA_00625 9.85e-88 ytcD - - K - - - Transcriptional regulator
MANCPEPA_00626 1.22e-246 gapB 1.2.1.12 - G ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MANCPEPA_00627 2.42e-88 speH 4.1.1.50 - E ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MANCPEPA_00628 2.42e-105 nrdR - - K ko:K07738 - ko00000,ko03000 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MANCPEPA_00629 0.0 dnaB - - L ko:K03346 - ko00000,ko03032 Membrane attachment protein
MANCPEPA_00630 1.22e-220 dnaI - - L ko:K11144 - ko00000,ko03032 Primosomal protein DnaI
MANCPEPA_00631 9.77e-144 ytxB - - S - - - SNARE associated Golgi protein
MANCPEPA_00632 2e-204 ytxC - - S - - - YtxC-like family
MANCPEPA_00634 0.0 thrS 6.1.1.3 - J ko:K01868 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MANCPEPA_00635 1.4e-189 ysaA 3.1.3.5, 3.8.1.2 - S ko:K01560,ko:K07025,ko:K08723 ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120 ko00000,ko00001,ko01000 HAD-hyrolase-like
MANCPEPA_00636 0.0 lytS 2.7.13.3 - T ko:K07704 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_00637 3.39e-167 lytT - - T ko:K07705 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG3279 Response regulator of the LytR AlgR family
MANCPEPA_00638 8.47e-85 lrgA - - S ko:K05338 ko02020,map02020 ko00000,ko00001,ko02000 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MANCPEPA_00639 5.34e-150 lrgB - - M ko:K05339 ko02020,map02020 ko00000,ko00001 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MANCPEPA_00641 1.81e-111 infC - - J ko:K02520 - ko00000,ko03012,ko03029 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MANCPEPA_00642 3.93e-37 rpmI - - J ko:K02916 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL35 family
MANCPEPA_00643 3.26e-76 rplT - - J ko:K02887 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MANCPEPA_00644 1.27e-59 ysdA - - S - - - Membrane
MANCPEPA_00645 1.96e-89 ysdB - - S - - - Sigma-w pathway protein YsdB
MANCPEPA_00646 8.77e-262 ysdC - - G - - - COG1363 Cellulase M and related proteins
MANCPEPA_00647 9.92e-242 - 3.2.1.99 GH43 G ko:K06113 - ko00000,ko01000 Belongs to the glycosyl hydrolase 43 family
MANCPEPA_00648 0.0 araA 5.3.1.4 - G ko:K01804 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko01000 Catalyzes the conversion of L-arabinose to L-ribulose
MANCPEPA_00649 0.0 araB 2.7.1.16 - C ko:K00853 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko01000 Belongs to the ribulokinase family
MANCPEPA_00650 1.99e-169 araD 5.1.3.4 - G ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 ko00000,ko00001,ko00002,ko01000 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
MANCPEPA_00651 6.06e-187 araL - - G ko:K02101 - ko00000 Haloacid dehalogenase-like hydrolase
MANCPEPA_00652 1.07e-281 araM 1.1.1.261 - I ko:K00096 ko00564,map00564 ko00000,ko00001,ko01000 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
MANCPEPA_00653 0.0 araN - - G ko:K17234 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 carbohydrate transport
MANCPEPA_00654 1.12e-217 araP - - G ko:K17235 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 carbohydrate transport
MANCPEPA_00655 1.23e-189 araQ - - G ko:K17236 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 transport system permease
MANCPEPA_00656 0.0 abfA 3.2.1.55 GH51 G ko:K01209 ko00520,map00520 ko00000,ko00001,ko01000 alpha-L-arabinofuranosidase activity
MANCPEPA_00657 0.0 cstA - - T ko:K06200 - ko00000 Carbon starvation protein
MANCPEPA_00658 8.8e-55 - 4.4.1.5 - E ko:K01759 ko00620,map00620 ko00000,ko00001,ko01000 Glyoxalase-like domain
MANCPEPA_00659 0.0 glcF - - C ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 ko00000,ko00001 Glycolate oxidase
MANCPEPA_00660 0.0 glcD 1.1.3.15 - C ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 ko00000,ko00001,ko01000 Glycolate oxidase subunit
MANCPEPA_00661 2.51e-260 cdaR_1 - - KT ko:K02647 - ko00000,ko03000 regulator
MANCPEPA_00662 7.54e-44 sspI - - S ko:K06426 - ko00000 Belongs to the SspI family
MANCPEPA_00663 3.13e-171 spoU - - J ko:K03437 - ko00000,ko03016 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MANCPEPA_00664 1.81e-250 pheS 6.1.1.20 - J ko:K01889 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MANCPEPA_00665 0.0 pheT 6.1.1.20 - J ko:K01890 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MANCPEPA_00666 2.96e-215 rnhC 3.1.26.4 - L ko:K03471 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MANCPEPA_00667 1.04e-54 zapA - - D ko:K09888 - ko00000,ko03036 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MANCPEPA_00668 1.09e-111 yshB - - S - - - membrane protein, required for colicin V production
MANCPEPA_00669 0.0 polX - - L ko:K02347 - ko00000,ko03400 COG1796 DNA polymerase IV (family X)
MANCPEPA_00670 0.0 mutS2 - - L ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MANCPEPA_00671 3.76e-89 yshE - - S ko:K08989 - ko00000 membrane
MANCPEPA_00672 0.0 lcfA 6.2.1.3 - IQ ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MANCPEPA_00673 1.21e-130 fadR - - K ko:K13770 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_00674 3.12e-176 fadB 4.2.1.17 - I ko:K13767 ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212 ko00000,ko00001,ko00002,ko01000 Belongs to the enoyl-CoA hydratase isomerase family
MANCPEPA_00675 2.58e-179 etfB - - C ko:K03521 - ko00000 Electron transfer flavoprotein
MANCPEPA_00676 3.02e-228 etfA - - C ko:K03522 - ko00000,ko04147 Electron transfer flavoprotein
MANCPEPA_00678 0.0 xsa 3.2.1.55 GH51 G ko:K01209 ko00520,map00520 ko00000,ko00001,ko01000 Alpha-L-arabinofuranosidase C-terminus
MANCPEPA_00679 1.12e-69 trxA - - O ko:K03671 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Belongs to the thioredoxin family
MANCPEPA_00680 0.0 uvrC - - L ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MANCPEPA_00681 6.56e-274 lysC 2.7.2.4 - E ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the aspartokinase family
MANCPEPA_00682 3.48e-103 yslB - - S - - - Protein of unknown function (DUF2507)
MANCPEPA_00683 1.35e-140 sdhC - - C ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002 succinate dehydrogenase
MANCPEPA_00684 0.0 sdhA 1.3.5.1, 1.3.5.4 - C ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 ko00000,ko00001,ko00002,ko01000 succinate dehydrogenase
MANCPEPA_00685 1.15e-189 sdhB 1.3.5.1, 1.3.5.4 - C ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 succinate dehydrogenase
MANCPEPA_00686 1.79e-100 ysmA - - S ko:K07107 - ko00000,ko01000 thioesterase
MANCPEPA_00687 1.81e-41 gerE - - K ko:K01994 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_00688 1.6e-98 ysmB - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_00689 1.15e-196 murI 3.6.1.66, 5.1.1.3 - M ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 ko00000,ko00001,ko01000,ko01011 Provides the (R)-glutamate required for cell wall biosynthesis
MANCPEPA_00690 8.03e-256 gerM - - S ko:K06298 - ko00000 COG5401 Spore germination protein
MANCPEPA_00691 3.53e-171 rph 2.7.7.56 - J ko:K00989 - ko00000,ko01000,ko03016 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MANCPEPA_00692 1.06e-132 rdgB 3.6.1.66 - F ko:K02428 ko00230,map00230 ko00000,ko00001,ko01000 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MANCPEPA_00693 4.05e-119 ysnB - - S ko:K07095 - ko00000 Phosphoesterase
MANCPEPA_00695 1.01e-184 ysnF - - S - - - protein conserved in bacteria
MANCPEPA_00696 3.32e-107 ysnE - - K ko:K03829 - ko00000,ko01000 acetyltransferase
MANCPEPA_00698 0.0 ilvB 2.2.1.6 - E ko:K01652,ko:K16787 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Acetolactate synthase
MANCPEPA_00699 5.05e-110 ilvN 2.2.1.6 - E ko:K01653,ko:K16785 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Acetolactate synthase
MANCPEPA_00700 9.59e-245 ilvC 1.1.1.86 - EH ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MANCPEPA_00701 0.0 leuA 2.3.3.13 - E ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MANCPEPA_00702 1.06e-255 leuB 1.1.1.85 - CE ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MANCPEPA_00703 0.0 leuC 4.2.1.33, 4.2.1.35 - E ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MANCPEPA_00704 5.35e-150 leuD 4.2.1.33, 4.2.1.35 - E ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MANCPEPA_00705 2.73e-240 ysoA - - H - - - Tetratricopeptide repeat
MANCPEPA_00706 8.87e-287 tig - - D ko:K03545 - ko00000 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MANCPEPA_00707 1.15e-296 clpX - - O ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MANCPEPA_00708 0.0 lonB 3.4.21.53 - LO ko:K04076 - ko00000,ko01000,ko01002 Belongs to the peptidase S16 family
MANCPEPA_00709 0.0 lon 3.4.21.53 - O ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MANCPEPA_00710 7.6e-139 engB - - D ko:K03978 - ko00000,ko03036 Necessary for normal cell division and for the maintenance of normal septation
MANCPEPA_00711 6.77e-116 ysxD - - - - - - -
MANCPEPA_00712 6.39e-316 hemA 1.2.1.70 - H ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MANCPEPA_00713 6.56e-187 hemX - - O ko:K02497 - ko00000 cytochrome C
MANCPEPA_00714 8.91e-220 hemC 2.5.1.61 - H ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
MANCPEPA_00715 1.44e-183 hemD 4.2.1.75 - H ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Uroporphyrinogen-III synthase
MANCPEPA_00716 1.51e-232 hemB 4.2.1.24 - H ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the ALAD family
MANCPEPA_00717 3.53e-312 hemL 5.4.3.8 - H ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000,ko01007 Glutamate-1-semialdehyde aminotransferase
MANCPEPA_00718 0.0 spoVID - - M ko:K06417 - ko00000 stage VI sporulation protein D
MANCPEPA_00719 9.34e-250 ysxE - - S - - - A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MANCPEPA_00720 1.53e-35 - - - - - - - -
MANCPEPA_00721 0.0 valS 6.1.1.9 - J ko:K01873 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MANCPEPA_00722 1.55e-315 folC 6.3.2.12, 6.3.2.17 - H ko:K11754 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the folylpolyglutamate synthase family
MANCPEPA_00723 9e-109 comC 3.4.23.43 - NOU ko:K02236,ko:K02654 - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
MANCPEPA_00724 7.89e-207 spoIIB - - S ko:K06380 - ko00000 Sporulation related domain
MANCPEPA_00725 2.02e-131 maf - - D ko:K06287 - ko00000 septum formation protein Maf
MANCPEPA_00726 2.4e-162 radC - - E ko:K03630 - ko00000 Belongs to the UPF0758 family
MANCPEPA_00727 5.26e-235 mreB - - D ko:K03569 - ko00000,ko02048,ko03036,ko04812 Rod shape-determining protein MreB
MANCPEPA_00728 1.91e-202 mreC - - M ko:K03570 - ko00000,ko03036 Involved in formation and maintenance of cell shape
MANCPEPA_00729 8.72e-111 mreD - - M ko:K03571 - ko00000,ko03036 shape-determining protein
MANCPEPA_00730 4.3e-158 minC - - D ko:K03610 - ko00000,ko03036,ko04812 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
MANCPEPA_00731 6.84e-185 minD - - D ko:K03609 - ko00000,ko03036,ko04812 Belongs to the ParA family
MANCPEPA_00732 1.06e-186 spoIVFA - - M ko:K06401 - ko00000 COG0739 Membrane proteins related to metalloendopeptidases
MANCPEPA_00733 1.52e-207 spoIVFB - - S ko:K06402 - ko00000,ko01000,ko01002 Stage IV sporulation protein
MANCPEPA_00734 1.82e-65 rplU - - J ko:K02888 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This protein binds to 23S rRNA in the presence of protein L20
MANCPEPA_00735 2.66e-74 ysxB - - J ko:K07584 - ko00000 ribosomal protein
MANCPEPA_00736 2.7e-61 rpmA - - J ko:K02899 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL27 family
MANCPEPA_00737 4.25e-139 spo0B - - T ko:K06375 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko01000 Sporulation initiation phospho-transferase B, C-terminal
MANCPEPA_00738 5.59e-308 obg - - S ko:K03979 - ko00000,ko01000,ko03009 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MANCPEPA_00739 4.75e-96 pheB 5.4.99.5 - S ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the UPF0735 family
MANCPEPA_00740 1.43e-208 pheA 4.2.1.51 - E ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Prephenate dehydratase
MANCPEPA_00741 5.02e-123 yrxA - - S ko:K07105 - ko00000 small molecule binding protein (contains 3H domain)
MANCPEPA_00742 2.43e-283 nifS 2.8.1.7 - E ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Cysteine desulfurase
MANCPEPA_00743 0.0 nadB 1.4.3.16 - H ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of L-aspartate to iminoaspartate
MANCPEPA_00744 4.34e-203 nadC 2.4.2.19 - H ko:K00767 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the NadC ModD family
MANCPEPA_00745 6.53e-272 nadA 2.5.1.72 - H ko:K03517 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MANCPEPA_00746 1.71e-217 safA - - M ko:K06370 - ko00000 spore coat assembly protein SafA
MANCPEPA_00747 1.47e-69 - - - S ko:K06345 - ko00000 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MANCPEPA_00748 1.01e-163 yebC - - K - - - transcriptional regulatory protein
MANCPEPA_00749 0.0 yrbD - - E ko:K03310 - ko00000 Sodium alanine symporter
MANCPEPA_00750 2.55e-67 - - - S - - - Family of unknown function (DUF5412)
MANCPEPA_00752 9.45e-152 yrzF - - T - - - serine threonine protein kinase
MANCPEPA_00753 6.51e-247 idhA 1.1.1.18, 1.1.1.369 - S ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 ko00000,ko00001,ko01000 Oxidoreductase family, NAD-binding Rossmann fold
MANCPEPA_00754 0.0 csbX - - EGP - - - the major facilitator superfamily
MANCPEPA_00755 6.46e-121 bofC - - S ko:K06318 - ko00000 BofC C-terminal domain
MANCPEPA_00756 2.84e-137 ruvA 3.6.4.12 - L ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MANCPEPA_00757 9.14e-239 ruvB 3.6.4.12 - L ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MANCPEPA_00758 1.68e-29 yrzS - - S - - - Protein of unknown function (DUF2905)
MANCPEPA_00759 6.03e-248 queA 2.4.99.17 - J ko:K07568 - ko00000,ko01000,ko03016 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MANCPEPA_00760 4.74e-292 tgt 2.4.2.29 - F ko:K00773 - ko00000,ko01000,ko03016 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MANCPEPA_00761 1.29e-52 yajC - - U ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Preprotein translocase subunit YajC
MANCPEPA_00762 1.46e-96 yrzE - - S - - - Protein of unknown function (DUF3792)
MANCPEPA_00763 5.83e-143 yrbG - - S - - - membrane
MANCPEPA_00764 0.0 spoVB - - S ko:K06409 - ko00000,ko02000 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_00765 5.53e-65 yrzD - - S - - - Post-transcriptional regulator
MANCPEPA_00766 0.0 secD - - U ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MANCPEPA_00767 1.08e-112 trkA1 - - P ko:K07228 - ko00000 regulatory, ligand-binding protein related to C-terminal domains of K channels
MANCPEPA_00768 1.07e-64 yrvD - - S - - - Lipopolysaccharide assembly protein A domain
MANCPEPA_00769 0.0 recJ - - L ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Single-stranded-DNA-specific exonuclease RecJ
MANCPEPA_00770 2.53e-118 apt 2.4.2.7 - F ko:K00759 ko00230,ko01100,map00230,map01100 ko00000,ko00001,ko01000,ko04147 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MANCPEPA_00771 0.0 relA 2.7.6.5 - KT ko:K00951 ko00230,map00230 ko00000,ko00001,ko01000 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MANCPEPA_00772 1.36e-90 dtd - - J ko:K07560 - ko00000,ko01000,ko03016 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MANCPEPA_00773 0.0 lytH 3.5.1.28 - M ko:K01448 ko01503,map01503 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 COG3103 SH3 domain protein
MANCPEPA_00775 1.49e-310 hisS 6.1.1.21 - J ko:K01892 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 histidyl-tRNA synthetase
MANCPEPA_00776 0.0 aspS 6.1.1.12 - J ko:K01876 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MANCPEPA_00777 5.63e-177 yrvM - - H ko:K22132 - ko00000,ko03016 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
MANCPEPA_00778 2.44e-303 rarA - - L ko:K07478 - ko00000 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
MANCPEPA_00779 8.12e-93 cymR - - K ko:K17472 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_00780 1.8e-270 iscS 2.8.1.7 - E ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Cysteine desulfurase
MANCPEPA_00781 1.19e-280 mnmA 2.8.1.13 - J ko:K00566 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MANCPEPA_00782 1.01e-20 yrrB - - S - - - COG0457 FOG TPR repeat
MANCPEPA_00783 0.0 recD2 3.1.11.5 - L ko:K03581 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MANCPEPA_00784 5.87e-107 yrrD - - S - - - protein conserved in bacteria
MANCPEPA_00785 8.4e-42 yrzR - - - - - - -
MANCPEPA_00786 5.38e-12 - - - S - - - Protein of unknown function (DUF3918)
MANCPEPA_00787 9.26e-140 glnP - - P ko:K10040 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter
MANCPEPA_00788 1.32e-138 glnM - - P ko:K10040 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter
MANCPEPA_00789 8.63e-186 glnH - - ET ko:K09969,ko:K10039 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the bacterial solute-binding protein 3 family
MANCPEPA_00790 8.99e-168 glnQ - - E ko:K09972,ko:K10041 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1126 ABC-type polar amino acid transport system, ATPase component
MANCPEPA_00791 8.08e-238 yrrI - - S - - - AI-2E family transporter
MANCPEPA_00792 0.0 alaS 6.1.1.7 - J ko:K01872 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MANCPEPA_00793 2.22e-55 yrzL - - S - - - Belongs to the UPF0297 family
MANCPEPA_00794 5.49e-93 yrrK - - L ko:K07447 - ko00000,ko01000 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MANCPEPA_00795 2.94e-60 yrzB - - S - - - Belongs to the UPF0473 family
MANCPEPA_00796 7.51e-242 mltG - - S ko:K07082 - ko00000 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MANCPEPA_00797 2.82e-154 yrrM 2.1.1.104 - S ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 ko00000,ko00001,ko00002,ko01000 O-methyltransferase
MANCPEPA_00798 6.57e-224 yrrN - - O ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Peptidase U32
MANCPEPA_00799 4.62e-313 yrrO - - O ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 COG0826 Collagenase and related proteases
MANCPEPA_00800 4.51e-148 udk 2.7.1.48 - F ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 ko00000,ko00001,ko01000 Cytidine monophosphokinase
MANCPEPA_00801 1.14e-101 greA - - K ko:K03624 - ko00000,ko03021 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MANCPEPA_00802 0.0 pbpI - - M ko:K21468 - ko00000,ko01011 Penicillin-binding Protein
MANCPEPA_00803 2.34e-101 yrrS - - S - - - Protein of unknown function (DUF1510)
MANCPEPA_00804 4.94e-36 yrzA - - S - - - Protein of unknown function (DUF2536)
MANCPEPA_00805 3.44e-153 yrrT - - Q ko:K17462 ko00270,ko01100,ko01230,map00270,map01100,map01230 ko00000,ko00001,ko00002,ko01000 Could be a S-adenosyl-L-methionine-dependent methyltransferase
MANCPEPA_00806 3.26e-160 mtnN 3.2.2.9 - E ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MANCPEPA_00807 1.66e-216 mccA 2.5.1.134, 2.5.1.47 - E ko:K01738,ko:K17216 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Cysteine synthase
MANCPEPA_00808 2.45e-268 mccB 4.4.1.1, 4.4.1.2, 4.4.1.8 - E ko:K01760,ko:K17217 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 cystathionine
MANCPEPA_00809 6.93e-49 yrhC - - S - - - YrhC-like protein
MANCPEPA_00810 1.73e-102 yrhD - - S - - - Protein of unknown function (DUF1641)
MANCPEPA_00811 0.0 yjgC 1.17.1.9 - C ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko00000,ko00001,ko01000 formate dehydrogenase (NAD+) activity
MANCPEPA_00812 4.41e-80 yrhF - - S - - - Uncharacterized conserved protein (DUF2294)
MANCPEPA_00814 1.38e-183 yrhG - - P ko:K21993 - ko00000,ko02000 Formate nitrite
MANCPEPA_00816 9.39e-08 - - - S - - - Probable sporulation protein (Bac_small_yrzI)
MANCPEPA_00817 1.1e-126 yrhH - - Q - - - methyltransferase
MANCPEPA_00818 1.12e-135 - - - K ko:K22106 - ko00000,ko03000 Tetracycline repressor, C-terminal all-alpha domain
MANCPEPA_00819 0.0 yrhJ 1.14.14.1, 1.6.2.4 - C ko:K14338 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 ko00000,ko00001,ko00199,ko01000 Belongs to the cytochrome P450 family
MANCPEPA_00820 1.09e-61 yrhK - - S - - - YrhK-like protein
MANCPEPA_00821 0.0 oatA - - I - - - Acyltransferase family
MANCPEPA_00822 7.4e-193 rsiV - - S - - - Protein of unknown function (DUF3298)
MANCPEPA_00823 8.2e-113 sigV - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_00824 1.98e-192 yrhO - - K - - - Archaeal transcriptional regulator TrmB
MANCPEPA_00825 1.61e-136 yrhP - - E - - - LysE type translocator
MANCPEPA_00826 0.0 aapA - - E ko:K03293,ko:K11737 - ko00000,ko02000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_00827 0.0 levR - - K - - - PTS system fructose IIA component
MANCPEPA_00828 4.41e-96 levD 2.7.1.191, 2.7.1.202 - G ko:K02793,ko:K02794,ko:K11194 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 PTS system fructose IIA component
MANCPEPA_00829 7.63e-107 ptnA 2.7.1.191, 2.7.1.202 - G ko:K02793,ko:K02794,ko:K11195 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 PTS system mannose fructose sorbose family
MANCPEPA_00830 6.11e-168 levF - - G ko:K02746,ko:K02795,ko:K11196 ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko00000,ko00001,ko00002,ko02000 COG3715 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IIC
MANCPEPA_00831 1.39e-192 levG - - G ko:K02771,ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 ko00000,ko00001,ko00002,ko02000 COG3716 Phosphotransferase system, mannose fructose N-acetylgalactosamine-specific component IID
MANCPEPA_00832 0.0 sacC 3.2.1.80 - G ko:K03332 ko00051,map00051 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 32 family
MANCPEPA_00833 1.58e-116 yfkM 3.5.1.124 - S ko:K05520 - ko00000,ko01000,ko01002 protease
MANCPEPA_00834 4.81e-253 adhA - - C ko:K13979 - ko00000,ko01000 alcohol dehydrogenase
MANCPEPA_00835 1.76e-39 yphJ 4.1.1.44 - S ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 ko00000,ko00001,ko01000 peroxiredoxin activity
MANCPEPA_00836 1.83e-67 adhR - - K ko:K21745 - ko00000,ko03000 helix_turn_helix, mercury resistance
MANCPEPA_00837 7.23e-66 yraD - - M ko:K06439 - ko00000 Spore coat protein
MANCPEPA_00838 6.11e-36 yraE - - - ko:K06440 - ko00000 -
MANCPEPA_00839 9.1e-284 adhB 1.1.1.1, 1.1.1.284, 1.2.1.46 - E ko:K00121,ko:K00148 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 ko00000,ko00001,ko01000 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MANCPEPA_00840 9.61e-84 yraF - - M - - - Spore coat protein
MANCPEPA_00841 1.2e-49 yraG - - - ko:K06440 - ko00000 -
MANCPEPA_00842 5.45e-86 - - - E - - - Glyoxalase-like domain
MANCPEPA_00844 2.92e-81 - - - T - - - sh3 domain protein
MANCPEPA_00845 6.61e-80 - - - T - - - sh3 domain protein
MANCPEPA_00846 3.41e-191 - - - S - - - Alpha beta hydrolase
MANCPEPA_00847 6.94e-54 yraL - - S - - - COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_00848 3e-191 csn 3.2.1.132 - M ko:K01233 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
MANCPEPA_00849 1.15e-260 yraM - - S - - - PrpF protein
MANCPEPA_00850 7e-209 yraN - - K - - - Transcriptional regulator
MANCPEPA_00851 1.77e-284 yraO - - C ko:K03300,ko:K11639 ko02020,map02020 ko00000,ko00001 Citrate transporter
MANCPEPA_00852 4.9e-239 yrpG - - C - - - Aldo/keto reductase family
MANCPEPA_00853 1.39e-118 - - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_00854 1.04e-166 zinT - - S ko:K09815 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment
MANCPEPA_00855 4.65e-63 - - - S - - - YjbR
MANCPEPA_00856 1.12e-156 - - - K ko:K19575 - ko00000,ko00002,ko03000 helix_turn_helix, mercury resistance
MANCPEPA_00857 3.1e-126 - - - S - - - Flavin reductase like domain
MANCPEPA_00858 4.98e-172 - 2.2.1.1 - G ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 COG3959 Transketolase, N-terminal subunit
MANCPEPA_00859 8.71e-194 - 2.2.1.1 - G ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Transketolase, pyrimidine binding domain
MANCPEPA_00860 6.21e-148 - - - IQ - - - COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_00861 1.67e-267 - - - P - - - Major Facilitator Superfamily
MANCPEPA_00863 1.16e-128 - - - K ko:K05799 - ko00000,ko03000 helix_turn_helix gluconate operon transcriptional repressor
MANCPEPA_00864 5.63e-161 yrpD - - S - - - Domain of unknown function, YrpD
MANCPEPA_00865 6.37e-35 murI 5.1.1.3 - M ko:K01776 ko00471,ko01100,map00471,map01100 ko00000,ko00001,ko01000,ko01011 Provides the (R)-glutamate required for cell wall biosynthesis
MANCPEPA_00866 3.23e-121 npd 1.13.12.16 - S ko:K00459 ko00910,map00910 ko00000,ko00001,ko01000 COG2070 Dioxygenases related to 2-nitropropane dioxygenase
MANCPEPA_00868 1.84e-105 murI 5.1.1.3 - M ko:K01776 ko00471,ko01100,map00471,map01100 ko00000,ko00001,ko01000,ko01011 Provides the (R)-glutamate required for cell wall biosynthesis
MANCPEPA_00869 1.68e-70 npd 1.13.12.16 - S ko:K00459 ko00910,map00910 ko00000,ko00001,ko01000 COG2070 Dioxygenases related to 2-nitropropane dioxygenase
MANCPEPA_00870 8.2e-210 aadK - - G ko:K05593 - ko00000,ko01000,ko01504 Streptomycin adenylyltransferase
MANCPEPA_00871 1.42e-118 yrdA - - S - - - DinB family
MANCPEPA_00872 1.42e-69 - - - S - - - Protein of unknown function (DUF2568)
MANCPEPA_00873 7.38e-131 yrdC - - Q - - - Isochorismatase family
MANCPEPA_00875 1.88e-290 cypA 1.14.14.46, 1.14.15.13 - C ko:K15468,ko:K16593,ko:K17474 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko00199,ko01000,ko01008 Cytochrome P450
MANCPEPA_00876 1.76e-22 yrdF - - K ko:K03623 - ko00000 ribonuclease inhibitor
MANCPEPA_00877 4.13e-104 bkdR - - K - - - helix_turn_helix ASNC type
MANCPEPA_00878 9.34e-176 azlC - - E - - - AzlC protein
MANCPEPA_00879 1.97e-66 azlD - - E - - - Branched-chain amino acid transport protein (AzlD)
MANCPEPA_00880 2.47e-292 brnQ - - E ko:K03311 - ko00000 Component of the transport system for branched-chain amino acids
MANCPEPA_00881 2.43e-208 - - - K ko:K21959 - ko00000,ko03000 LysR substrate binding domain
MANCPEPA_00882 3.53e-87 yodA - - S - - - tautomerase
MANCPEPA_00883 9.32e-201 czcD - - P ko:K16264 - ko00000,ko02000 COG1230 Co Zn Cd efflux system component
MANCPEPA_00884 5.22e-255 trkA - - P ko:K07222 - ko00000 Oxidoreductase
MANCPEPA_00885 9.47e-202 - - - K - - - Transcriptional regulator
MANCPEPA_00886 1.41e-215 yrdR - - EG - - - EamA-like transporter family
MANCPEPA_00887 2.45e-23 - - - S - - - YrzO-like protein
MANCPEPA_00888 2.06e-297 yrkA - - S - - - COG1253 Hemolysins and related proteins containing CBS domains
MANCPEPA_00889 7.23e-107 bltD 2.3.1.57 - K ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 ko00000,ko00001,ko00002,ko01000 FR47-like protein
MANCPEPA_00890 1.08e-268 blt - - EGP ko:K08153,ko:K19578 - ko00000,ko00002,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_00891 1.24e-194 bltR - - K - - - helix_turn_helix, mercury resistance
MANCPEPA_00892 5.21e-137 yrkC - - G - - - Cupin domain
MANCPEPA_00893 4.38e-52 yrkD - - S - - - protein conserved in bacteria
MANCPEPA_00894 1.61e-107 yrkE - - O - - - DsrE/DsrF/DrsH-like family
MANCPEPA_00895 2.28e-126 yrkF - - OP - - - Belongs to the sulfur carrier protein TusA family
MANCPEPA_00896 2.16e-265 yrkH - - P - - - Rhodanese Homology Domain
MANCPEPA_00897 1.3e-48 yrkI - - O - - - Belongs to the sulfur carrier protein TusA family
MANCPEPA_00898 2.21e-160 yrkJ - - S ko:K07090 - ko00000 membrane transporter protein
MANCPEPA_00899 3.1e-208 ydhT1 3.2.1.78 GH26 G ko:K01218 ko00051,ko02024,map00051,map02024 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 26 family
MANCPEPA_00900 2.23e-274 mepA - - V ko:K18908 - ko00000,ko00002,ko01504,ko02000 Multidrug transporter MatE
MANCPEPA_00901 1.94e-145 tetR3 - - K ko:K18476 - ko00000,ko00002,ko03000 Transcriptional regulator
MANCPEPA_00902 4.46e-79 sigK - - K ko:K03091 - ko00000,ko03021 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_00903 5.51e-123 xkdA - - E - - - IrrE N-terminal-like domain
MANCPEPA_00905 6.63e-127 yqaC - - F - - - adenylate kinase activity
MANCPEPA_00907 1.88e-42 - - - K - - - sequence-specific DNA binding
MANCPEPA_00908 5.37e-25 - - - K ko:K07729 - ko00000,ko03000 Helix-turn-helix XRE-family like proteins
MANCPEPA_00910 1.27e-134 - - - - - - - -
MANCPEPA_00914 3.18e-213 yqaJ - - L - - - YqaJ-like viral recombinase domain
MANCPEPA_00915 2.79e-192 recT - - L ko:K07455 - ko00000,ko03400 RecT family
MANCPEPA_00916 8.41e-153 yqaL - - L - - - DnaD domain protein
MANCPEPA_00917 2.72e-211 yqaM - - L - - - IstB-like ATP binding protein
MANCPEPA_00919 5.21e-93 rusA - - L - - - Endodeoxyribonuclease RusA
MANCPEPA_00920 1.24e-41 yqaO - - S - - - Phage-like element PBSX protein XtrA
MANCPEPA_00923 1.71e-100 yqaQ - - L - - - Transposase
MANCPEPA_00926 5.44e-147 yqaS - - L - - - DNA packaging
MANCPEPA_00927 1.89e-312 yqaT - - S ko:K06909 - ko00000 phage terminase, large subunit
MANCPEPA_00928 0.0 yqbA - - S - - - portal protein
MANCPEPA_00929 1.37e-182 - - - S - - - Phage Mu protein F like protein
MANCPEPA_00931 3.46e-157 yqbD - - L - - - Putative phage serine protease XkdF
MANCPEPA_00932 4.37e-214 xkdG - - S - - - Phage capsid family
MANCPEPA_00933 1.49e-60 - - - S - - - YqbF, hypothetical protein domain
MANCPEPA_00934 2.89e-87 - - - S - - - Protein of unknown function (DUF3199)
MANCPEPA_00935 2.38e-83 yqbH - - S - - - Domain of unknown function (DUF3599)
MANCPEPA_00936 7.57e-114 - - - S - - - Bacteriophage HK97-gp10, putative tail-component
MANCPEPA_00937 8.94e-100 yqbJ - - - - - - -
MANCPEPA_00938 4.2e-35 - - - - - - - -
MANCPEPA_00939 0.0 xkdK - - S - - - Phage tail sheath C-terminal domain
MANCPEPA_00940 1.21e-98 xkdM - - S - - - Phage tail tube protein
MANCPEPA_00941 1.27e-89 - - - S - - - Phage XkdN-like tail assembly chaperone protein, TAC
MANCPEPA_00942 0.0 xkdO - - L - - - Transglycosylase SLT domain
MANCPEPA_00943 3.12e-154 xkdP - - S - - - Lysin motif
MANCPEPA_00944 1.02e-231 xkdQ - - G - - - NLP P60 protein
MANCPEPA_00945 6.68e-52 xkdR - - S - - - Protein of unknown function (DUF2577)
MANCPEPA_00946 1.89e-90 xkdS - - S - - - Protein of unknown function (DUF2634)
MANCPEPA_00947 8.13e-240 - - - S - - - Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MANCPEPA_00948 1.11e-125 - - - S - - - Uncharacterised protein conserved in bacteria (DUF2313)
MANCPEPA_00949 4.11e-52 - - - - - - - -
MANCPEPA_00950 1.19e-282 - - - - - - - -
MANCPEPA_00951 1.01e-73 xkdW - - S - - - XkdW protein
MANCPEPA_00952 9.34e-33 - - - - - - - -
MANCPEPA_00953 2.45e-213 xepA - - - - - - -
MANCPEPA_00954 1.19e-88 - - - S - - - Bacteriophage holin family
MANCPEPA_00955 9.72e-187 - 3.5.1.28 - M ko:K01447 - ko00000,ko01000 N-acetylmuramoyl-L-alanine amidase
MANCPEPA_00957 5.4e-80 - - - - - - - -
MANCPEPA_00959 7.3e-131 - - - S ko:K21492 - ko00000,ko02048 Suppressor of fused protein (SUFU)
MANCPEPA_00960 2.88e-61 - - - - - - - -
MANCPEPA_00961 8.71e-20 - - - S - - - SMI1 / KNR4 family
MANCPEPA_00962 2.81e-200 - - - S - - - Bacterial EndoU nuclease
MANCPEPA_00965 8.68e-120 - - - S - - - Tetratricopeptide repeat
MANCPEPA_00966 1.7e-187 yqcI - - S ko:K09190 - ko00000 YqcI/YcgG family
MANCPEPA_00967 1.53e-72 arsR - - K ko:K03892 - ko00000,ko03000 ArsR family transcriptional regulator
MANCPEPA_00968 2.56e-104 cadI 4.4.1.5 - E ko:K01759 ko00620,map00620 ko00000,ko00001,ko01000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_00969 7.13e-233 arsB - - P ko:K03325 - ko00000,ko02000 Arsenic resistance protein
MANCPEPA_00970 9.82e-101 arsC 1.20.4.1 - T ko:K03741 - ko00000,ko01000 Catalyzes the reduction of arsenate As(V) to arsenite As(III)
MANCPEPA_00971 0.0 - - - L ko:K06400 - ko00000 Recombinase
MANCPEPA_00972 1.1e-72 sigK - - K ko:K03091 - ko00000,ko03021 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_00973 2.53e-97 nucB - - M - - - Deoxyribonuclease NucA/NucB
MANCPEPA_00974 9.38e-171 - - - - - - - -
MANCPEPA_00975 2.19e-216 yqeC 1.1.1.343, 1.1.1.44 - G ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 6-phosphogluconate dehydrogenase
MANCPEPA_00976 1.62e-135 yqeD - - S - - - SNARE associated Golgi protein
MANCPEPA_00977 1.33e-173 xlyA 3.5.1.28 - M ko:K01447 - ko00000,ko01000 n-acetylmuramoyl-L-alanine amidase
MANCPEPA_00978 2.15e-180 yqeF - - E - - - GDSL-like Lipase/Acylhydrolase
MANCPEPA_00980 2.17e-123 yqeG - - S ko:K07015 - ko00000 hydrolase of the HAD superfamily
MANCPEPA_00981 4.78e-273 yqeH - - S ko:K06948 - ko00000,ko03009 In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
MANCPEPA_00982 6.94e-200 aroE 1.1.1.25 - E ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MANCPEPA_00983 8.95e-61 yhbY - - J ko:K07574 - ko00000,ko03009 RNA-binding protein containing KH domain, possibly ribosomal protein
MANCPEPA_00984 2.47e-141 nadD 2.7.7.18 - H ko:K00969 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MANCPEPA_00985 3.95e-132 yqeK - - H - - - HD superfamily hydrolase involved in NAD metabolism
MANCPEPA_00986 1.39e-81 rsfS - - J ko:K09710 - ko00000,ko03009 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MANCPEPA_00987 1.39e-178 yqeM - - Q - - - Methyltransferase
MANCPEPA_00988 2.69e-189 comER - - E ko:K02239 - ko00000,ko00002,ko02044 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MANCPEPA_00989 3.69e-135 comEA - - L ko:K02237 - ko00000,ko00002,ko02044 COG1555 DNA uptake protein and related DNA-binding proteins
MANCPEPA_00990 3.25e-137 comEB 3.5.4.12 - F ko:K01493 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000,ko02044 ComE operon protein 2
MANCPEPA_00991 0.0 comEC - - S ko:K02238 - ko00000,ko00002,ko02044 Competence protein ComEC
MANCPEPA_00992 2.36e-22 - - - S - - - YqzM-like protein
MANCPEPA_00993 2.01e-244 holA 2.7.7.7 - L ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 DNA polymerase III delta subunit
MANCPEPA_00994 4e-49 rpsT - - J ko:K02968 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds directly to 16S ribosomal RNA
MANCPEPA_00995 4.16e-259 gpr 3.4.24.78 - C ko:K06012 - ko00000,ko01000,ko01002 Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MANCPEPA_00996 9.53e-284 spoIIP - - M ko:K06385 - ko00000 stage II sporulation protein P
MANCPEPA_00997 7.06e-70 yqxA - - S - - - Protein of unknown function (DUF3679)
MANCPEPA_00998 0.0 lepA - - M ko:K03596 ko05134,map05134 ko00000,ko00001 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MANCPEPA_00999 2.9e-276 hemN - - H - - - Involved in the biosynthesis of porphyrin-containing compound
MANCPEPA_01000 1.65e-241 hrcA - - K ko:K03705 - ko00000,ko03000 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MANCPEPA_01001 4.36e-116 grpE - - O ko:K03687 - ko00000,ko03029,ko03110 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MANCPEPA_01002 0.0 dnaK - - O ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Heat shock 70 kDa protein
MANCPEPA_01003 3.41e-257 dnaJ - - O ko:K03686 - ko00000,ko03029,ko03110 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MANCPEPA_01004 5.63e-226 prmA - - J ko:K02687 - ko00000,ko01000,ko03009 Methylates ribosomal protein L11
MANCPEPA_01005 1.38e-178 rsmE 2.1.1.193 - J ko:K09761 - ko00000,ko01000,ko03009 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MANCPEPA_01006 0.0 yqeV 2.8.4.5 - J ko:K18707 - ko00000,ko01000,ko03016 ribosomal protein S12 methylthiotransferase
MANCPEPA_01007 1.4e-201 yqeW - - P ko:K03324 - ko00000,ko02000 COG1283 Na phosphate symporter
MANCPEPA_01008 1.03e-26 rpsU - - J ko:K02970 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bS21 family
MANCPEPA_01009 2.25e-90 yqeY - - S ko:K09117 - ko00000 Yqey-like protein
MANCPEPA_01010 5.37e-290 yqeZ - - O ko:K07403 - ko00000 COG1030 Membrane-bound serine protease (ClpP class)
MANCPEPA_01011 4.35e-192 yqfA - - S - - - UPF0365 protein
MANCPEPA_01012 6.04e-61 yqfB - - - - - - -
MANCPEPA_01013 2.07e-60 yqfC - - S - - - sporulation protein YqfC
MANCPEPA_01014 1.04e-242 yqfD - - S ko:K06438 - ko00000 Stage IV sporulation
MANCPEPA_01015 4.99e-224 phoH - - T ko:K06217 - ko00000 Phosphate starvation-inducible protein PhoH
MANCPEPA_01017 0.0 yqfF - - S ko:K07037 - ko00000 membrane-associated HD superfamily hydrolase
MANCPEPA_01018 8.68e-106 ybeY - - S ko:K07042 - ko00000,ko03009 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MANCPEPA_01019 4.75e-80 dgkA 2.7.1.107, 2.7.1.66 - M ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 ko00000,ko00001,ko01000 Diacylglycerol kinase
MANCPEPA_01020 6.71e-93 cdd 3.5.4.5 - F ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 ko00000,ko00001,ko01000 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MANCPEPA_01021 9.98e-215 era - - S ko:K03595 - ko00000,ko03009,ko03029 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MANCPEPA_01022 5.29e-27 - - - S - - - YqzL-like protein
MANCPEPA_01023 7.48e-187 recO - - L ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Involved in DNA repair and RecF pathway recombination
MANCPEPA_01024 2.12e-222 glyQ 6.1.1.14 - J ko:K01878 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 glycyl-tRNA synthetase alpha subunit
MANCPEPA_01025 0.0 glyS 6.1.1.14 - J ko:K01879 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Glycyl-tRNA synthetase beta subunit
MANCPEPA_01026 3.29e-144 ccpN - - K - - - CBS domain
MANCPEPA_01027 6.38e-191 yqfL 2.7.11.33, 2.7.4.28 - S ko:K09773 - ko00000,ko01000 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
MANCPEPA_01028 4.96e-113 yqxD - - S ko:K09768 - ko00000 Belongs to the UPF0178 family
MANCPEPA_01029 0.0 dnaG - - L ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MANCPEPA_01030 2.79e-254 sigA - - K ko:K03086 - ko00000,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MANCPEPA_01031 1.61e-81 cccA - - C ko:K13300 - ko00000 COG2010 Cytochrome c, mono- and diheme variants
MANCPEPA_01032 1.14e-148 trmK 2.1.1.217 - S ko:K06967 - ko00000,ko01000,ko03016 SAM-dependent methyltransferase
MANCPEPA_01033 5.35e-269 yqfO - - S - - - Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MANCPEPA_01034 1.75e-226 ispH 1.17.7.4 - IM ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MANCPEPA_01035 1.18e-47 yqfQ - - S - - - YqfQ-like protein
MANCPEPA_01036 7.7e-311 cshB 3.6.4.13 - JKL ko:K05592,ko:K18692 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MANCPEPA_01037 1.04e-214 nfo 3.1.21.2 - L ko:K01151 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MANCPEPA_01038 3.01e-49 yqfT - - S - - - Protein of unknown function (DUF2624)
MANCPEPA_01039 3.83e-199 yqfU - - S - - - Uncharacterized protein conserved in bacteria (DUF2179)
MANCPEPA_01040 2.79e-106 zur - - P ko:K02076 - ko00000,ko03000 Belongs to the Fur family
MANCPEPA_01041 8.25e-142 yqfW - - S ko:K05967 - ko00000 Belongs to the 5'(3')-deoxyribonucleotidase family
MANCPEPA_01042 2.38e-80 yqfX - - S - - - membrane
MANCPEPA_01043 5.22e-257 ispG 1.17.7.1, 1.17.7.3 - I ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MANCPEPA_01044 1.16e-62 yqfZ - - M ko:K06417 - ko00000 LysM domain
MANCPEPA_01045 4.54e-167 yqgB - - S - - - Protein of unknown function (DUF1189)
MANCPEPA_01046 8.25e-101 yqgC - - S ko:K09793 - ko00000 protein conserved in bacteria
MANCPEPA_01047 2.26e-148 sodA 1.15.1.1 - P ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 radicals which are normally produced within the cells and which are toxic to biological systems
MANCPEPA_01048 8e-293 yqgE - - EGP ko:K08222 - ko00000,ko02000 Major facilitator superfamily
MANCPEPA_01049 0.0 pbpA - - M ko:K21465,ko:K21466 ko00550,map00550 ko00000,ko00001,ko01011 penicillin-binding protein
MANCPEPA_01050 5.26e-205 pstS - - P ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 ko00000,ko00001,ko00002,ko02000 Phosphate
MANCPEPA_01051 7.11e-203 pstC - - P ko:K02037 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 probably responsible for the translocation of the substrate across the membrane
MANCPEPA_01052 5.26e-202 pstA - - P ko:K02038 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Phosphate transport system permease
MANCPEPA_01053 9.78e-190 pstBA 3.6.3.27 - P ko:K02036 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MANCPEPA_01054 1.57e-186 pstB 3.6.3.27 - P ko:K02036 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MANCPEPA_01055 1.09e-93 yqzC - - S - - - YceG-like family
MANCPEPA_01056 2.81e-67 yqzD - - - - - - -
MANCPEPA_01058 2.81e-257 yqgM 2.4.1.250 - M ko:K15521 - ko00000,ko01000 Glycosyl transferases group 1
MANCPEPA_01059 6.25e-29 rpmG - - J ko:K02913 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL33 family
MANCPEPA_01060 1.13e-136 fthC 6.3.3.2 - H ko:K01934 ko00670,ko01100,map00670,map01100 ko00000,ko00001,ko01000 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MANCPEPA_01061 3.38e-14 yqgO - - - - - - -
MANCPEPA_01062 0.0 gluP 3.4.21.105 - O ko:K19225 - ko00000,ko01000,ko01002 membrane protein (homolog of Drosophila rhomboid)
MANCPEPA_01063 9.15e-45 yqgQ - - S - - - Protein conserved in bacteria
MANCPEPA_01064 3.28e-230 glcK 2.7.1.2 - G ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Glucokinase
MANCPEPA_01065 0.0 yqgS 2.7.8.20 - M ko:K01138,ko:K19005 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko01000 Belongs to the LTA synthase family
MANCPEPA_01066 1.06e-283 yqgT 3.4.19.11 - E ko:K01308 - ko00000,ko01000,ko01002 Gamma-D-glutamyl-L-diamino acid endopeptidase
MANCPEPA_01067 6.08e-255 yqgU - - - - - - -
MANCPEPA_01068 7.34e-66 yqgV - - S - - - Thiamine-binding protein
MANCPEPA_01069 1.91e-31 yqgW - - S - - - Protein of unknown function (DUF2759)
MANCPEPA_01070 2.25e-157 yqgX 3.1.2.6 - S ko:K01069 ko00620,map00620 ko00000,ko00001,ko01000 COG0491 Zn-dependent hydrolases, including glyoxylases
MANCPEPA_01071 1.46e-50 yqgY - - S - - - Protein of unknown function (DUF2626)
MANCPEPA_01072 7.79e-85 yqgZ 1.20.4.1 - P ko:K00537,ko:K16509 - ko00000,ko01000 Belongs to the ArsC family
MANCPEPA_01074 2.49e-192 yqhA - - T ko:K17763 - ko00000,ko03021 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MANCPEPA_01075 1.42e-305 yqhB - - S - - - COG1253 Hemolysins and related proteins containing CBS domains
MANCPEPA_01076 1.51e-233 yqxL - - P - - - Mg2 transporter protein
MANCPEPA_01077 3.73e-09 yhcV - - S - - - COG0517 FOG CBS domain
MANCPEPA_01078 2.59e-256 comGA - - NU ko:K02243 - ko00000,ko00002,ko02044 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MANCPEPA_01079 1.24e-218 comGB - - NU ko:K02244 - ko00000,ko00002,ko02044 COG1459 Type II secretory pathway, component PulF
MANCPEPA_01080 5.33e-63 comGC - - U ko:K02245 - ko00000,ko00002,ko02044 Required for transformation and DNA binding
MANCPEPA_01081 3.12e-90 gspH - - NU ko:K02246,ko:K02457,ko:K02459,ko:K02672,ko:K08084,ko:K10926 ko03070,ko05111,map03070,map05111 ko00000,ko00001,ko00002,ko02035,ko02044 protein transport across the cell outer membrane
MANCPEPA_01082 3.45e-76 comGE - - - ko:K02247 - ko00000,ko00002,ko02044 -
MANCPEPA_01083 3.94e-44 comGF - - U ko:K02246,ko:K02248 - ko00000,ko00002,ko02044 Putative Competence protein ComGF
MANCPEPA_01084 1.54e-56 - - - S ko:K02249 - ko00000,ko00002,ko02044 ComG operon protein 7
MANCPEPA_01085 6.96e-37 yqzE - - S - - - YqzE-like protein
MANCPEPA_01086 6.36e-71 yqzG - - S - - - Protein of unknown function (DUF3889)
MANCPEPA_01087 2.19e-153 yqxM - - - ko:K19433 - ko00000 -
MANCPEPA_01088 4.27e-97 sipW 3.4.21.89 - U ko:K13280 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Signal peptidase
MANCPEPA_01089 1.82e-181 tasA_1 - - S ko:K06336 - ko00000,ko01002 Cell division protein FtsN
MANCPEPA_01090 3.69e-72 sinR - - K ko:K19449 - ko00000,ko03000 transcriptional
MANCPEPA_01091 4.84e-34 sinI - - S ko:K06372 - ko00000 Anti-repressor SinI
MANCPEPA_01092 9.14e-197 yqhG - - S - - - Bacterial protein YqhG of unknown function
MANCPEPA_01093 0.0 yqhH - - L - - - COG0553 Superfamily II DNA RNA helicases, SNF2 family
MANCPEPA_01094 1.11e-260 gcvT 2.1.2.10 - E ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 ko00000,ko00001,ko00002,ko01000 The glycine cleavage system catalyzes the degradation of glycine
MANCPEPA_01095 0.0 gcvPA 1.4.4.2 - E ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko00000,ko00001,ko01000 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANCPEPA_01096 0.0 gcvPB 1.4.4.2 - E ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko00000,ko00001,ko01000 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANCPEPA_01097 7.5e-83 yqhL - - P - - - COG0607 Rhodanese-related sulfurtransferase
MANCPEPA_01098 9.17e-204 lipM 6.3.1.20 - H ko:K03800 ko00785,ko01100,map00785,map01100 ko00000,ko00001,ko01000 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
MANCPEPA_01099 1.97e-97 mntR - - K ko:K03709 - ko00000,ko03000 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
MANCPEPA_01100 5.75e-209 yqhO - - S ko:K07001 - ko00000 esterase of the alpha-beta hydrolase superfamily
MANCPEPA_01101 5.18e-81 yqhP - - - - - - -
MANCPEPA_01102 1.21e-219 yqhQ - - S - - - Protein of unknown function (DUF1385)
MANCPEPA_01103 3.27e-120 yqhR - - S - - - Conserved membrane protein YqhR
MANCPEPA_01104 4.75e-101 aroQ 4.2.1.10 - E ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes a trans-dehydration via an enolate intermediate
MANCPEPA_01105 2.99e-249 yqhT 3.4.11.9, 3.4.13.9 - E ko:K01262,ko:K01271 - ko00000,ko01000,ko01002 COG0006 Xaa-Pro aminopeptidase
MANCPEPA_01106 4.8e-128 efp - - J ko:K02356 - ko00000,ko03012 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MANCPEPA_01107 2e-49 yqhV - - S - - - Protein of unknown function (DUF2619)
MANCPEPA_01108 5.79e-217 spoIIIAA - - S ko:K06390 - ko00000 stage III sporulation protein AA
MANCPEPA_01109 1.63e-110 spoIIIAB - - S ko:K06391 - ko00000 Stage III sporulation protein
MANCPEPA_01110 1.63e-39 spoIIIAC - - S ko:K06392 - ko00000 stage III sporulation protein AC
MANCPEPA_01111 1.93e-77 spoIIIAD - - S ko:K06393 - ko00000 Stage III sporulation protein AD
MANCPEPA_01112 7.65e-257 spoIIIAE - - S ko:K06394 - ko00000 stage III sporulation protein AE
MANCPEPA_01113 3.66e-131 spoIIIAF - - S ko:K06395 - ko00000 Stage III sporulation protein AF (Spore_III_AF)
MANCPEPA_01114 8.86e-148 spoIIIAG - - S ko:K06396 - ko00000 stage III sporulation protein AG
MANCPEPA_01115 1.64e-133 spoIIIAH - - S ko:K06397 - ko00000 SpoIIIAH-like protein
MANCPEPA_01116 3.21e-93 accB - - I ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MANCPEPA_01117 0.0 accC 6.3.4.14, 6.4.1.2 - I ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002,ko01000 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
MANCPEPA_01118 1.65e-88 yqhY - - S - - - protein conserved in bacteria
MANCPEPA_01119 4.8e-86 nusB - - K ko:K03625 - ko00000,ko03009,ko03021 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MANCPEPA_01120 1.07e-200 folD 1.5.1.5, 3.5.4.9 - F ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MANCPEPA_01121 3.55e-312 xseA 3.1.11.6 - L ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MANCPEPA_01122 1.09e-51 xseB 3.1.11.6 - L ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MANCPEPA_01123 4.2e-209 ispA 2.5.1.1, 2.5.1.10, 2.5.1.29 - H ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000,ko01006 Belongs to the FPP GGPP synthase family
MANCPEPA_01124 0.0 dxs 2.2.1.7 - H ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MANCPEPA_01125 1.77e-198 rrmJ 2.1.1.226, 2.1.1.227 - J ko:K06442 - ko00000,ko01000,ko03009 rRNA methylase
MANCPEPA_01126 3.75e-103 argR - - K ko:K03402 - ko00000,ko03000 Regulates arginine biosynthesis genes
MANCPEPA_01127 0.0 recN - - L ko:K03631 - ko00000,ko03400 May be involved in recombinational repair of damaged DNA
MANCPEPA_01128 1.26e-303 spoIVB 3.4.21.116 - M ko:K06399 - ko00000,ko01000,ko01002 Stage IV sporulation protein B
MANCPEPA_01129 1.89e-186 spo0A - - KT ko:K07699 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko02022 May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
MANCPEPA_01131 8.07e-273 yqiG - - C - - - COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
MANCPEPA_01132 2.26e-37 - - - - - - - -
MANCPEPA_01133 2.7e-137 lytC_1 3.5.1.28 - M ko:K01448 ko01503,map01503 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Cell wall hydrolase autolysin
MANCPEPA_01134 7.42e-172 yqiK 3.1.4.46 - C ko:K01126 ko00564,map00564 ko00000,ko00001,ko01000 glycerophosphoryl diester phosphodiesterase
MANCPEPA_01135 2.32e-280 mmgA 2.3.1.9 - I ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the thiolase family
MANCPEPA_01136 1.45e-200 mmgB 1.1.1.157 - I ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 ko00000,ko00001,ko01000 Dehydrogenase
MANCPEPA_01137 4.24e-269 mmgC - - I ko:K18244 - ko00000,ko01000 acyl-CoA dehydrogenase
MANCPEPA_01138 1.66e-267 mmgD 2.3.3.1 - C ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Belongs to the citrate synthase family
MANCPEPA_01139 0.0 prpD 4.2.1.79 - S ko:K01720 ko00640,map00640 ko00000,ko00001,ko01000 2-methylcitrate dehydratase
MANCPEPA_01140 7.23e-208 prpB 4.1.3.30, 5.4.2.9 - G ko:K01841,ko:K03417 ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130 ko00000,ko00001,ko01000 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MANCPEPA_01141 1.56e-46 yqzF - - S - - - Protein of unknown function (DUF2627)
MANCPEPA_01142 0.0 bkdR - - KT - - - Transcriptional regulator
MANCPEPA_01143 1.74e-198 ptb 2.3.1.19 - C ko:K00634 ko00650,ko01100,map00650,map01100 ko00000,ko00001,ko01000 phosphate butyryltransferase
MANCPEPA_01144 1.92e-262 ldh 1.4.1.9 - E ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 ko00000,ko00001,ko01000 Belongs to the Glu Leu Phe Val dehydrogenases family
MANCPEPA_01145 1.18e-255 buk 2.7.2.7 - C ko:K00929 ko00650,ko01100,map00650,map01100 ko00000,ko00001,ko01000 Belongs to the acetokinase family
MANCPEPA_01146 0.0 bfmBC 1.8.1.4 - C ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MANCPEPA_01147 2.24e-237 bfmBAA 1.2.4.4 - C ko:K00166 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 br01601,ko00000,ko00001,ko00002,ko01000 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MANCPEPA_01148 6.92e-235 bfmBAB 1.2.4.4 - C ko:K00167,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 br01601,ko00000,ko00001,ko00002,ko01000 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MANCPEPA_01149 1.08e-287 bkdB 2.3.1.12, 2.3.1.168 - C ko:K00627,ko:K09699 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MANCPEPA_01150 7.45e-194 - - - K ko:K19575 - ko00000,ko00002,ko03000 helix_turn_helix, mercury resistance
MANCPEPA_01151 3.09e-267 norA - - EGP ko:K08153,ko:K19576,ko:K19578 - ko00000,ko00002,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_01152 4.06e-212 bmrU - - I - - - COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MANCPEPA_01153 3.79e-101 yqiW - - S - - - Belongs to the UPF0403 family
MANCPEPA_01154 1.43e-175 artP - - ET ko:K02030 - ko00000,ko00002,ko02000 Belongs to the bacterial solute-binding protein 3 family
MANCPEPA_01155 8.94e-143 artQ - - E ko:K02029 - ko00000,ko00002,ko02000 COG0765 ABC-type amino acid transport system, permease component
MANCPEPA_01156 5.2e-166 artM 3.6.3.21 - E ko:K02028 - ko00000,ko00002,ko01000,ko02000 COG1126 ABC-type polar amino acid transport system, ATPase component
MANCPEPA_01157 1.88e-225 yqjA - - S - - - Putative aromatic acid exporter C-terminal domain
MANCPEPA_01158 2.41e-128 yqjB - - S - - - protein conserved in bacteria
MANCPEPA_01160 7.17e-99 mce 5.1.99.1 - E ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 COG0346 Lactoylglutathione lyase and related lyases
MANCPEPA_01161 0.0 yqjD 2.1.3.15, 6.4.1.3 - I ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MANCPEPA_01162 5.26e-259 yqjE 3.4.11.14, 3.4.11.4 - E ko:K01258,ko:K01263 - ko00000,ko01000,ko01002 COG2195 Di- and tripeptidases
MANCPEPA_01163 1.2e-181 yqjF - - S ko:K09166 - ko00000 Uncharacterized conserved protein (COG2071)
MANCPEPA_01164 3.36e-184 yidC - - U ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044,ko03029 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MANCPEPA_01165 1.77e-32 yqzJ - - - - - - -
MANCPEPA_01166 2.72e-301 dinB 2.7.7.7 - L ko:K02346 - ko00000,ko01000,ko03400 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MANCPEPA_01167 0.0 gnd 1.1.1.343, 1.1.1.44 - G ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MANCPEPA_01168 0.0 zwf 1.1.1.363, 1.1.1.49 - G ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MANCPEPA_01169 7.66e-222 rnz 3.1.26.11 - S ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MANCPEPA_01170 8.59e-27 rpmG - - J ko:K02913 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL33 family
MANCPEPA_01171 3.17e-187 yqjL - - S - - - hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MANCPEPA_01172 1.21e-245 namA 1.6.99.1 - C ko:K00354 - ko00000,ko01000 Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
MANCPEPA_01173 0.0 rocB - - E - - - arginine degradation protein
MANCPEPA_01174 1.13e-188 proC 1.5.1.2 - E ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MANCPEPA_01175 3.82e-228 yqjP - - S - - - COG0491 Zn-dependent hydrolases, including glyoxylases
MANCPEPA_01176 1.62e-183 yqjQ - - S ko:K07124 - ko00000 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_01177 0.0 dsdA 4.3.1.18 - E ko:K01753 ko00260,map00260 ko00000,ko00001,ko01000 Belongs to the serine threonine dehydratase family. DsdA subfamily
MANCPEPA_01178 6.6e-229 coaA 2.7.1.33 - F ko:K00867 ko00770,ko01100,map00770,map01100 ko00000,ko00001,ko00002,ko01000 Pantothenic acid kinase
MANCPEPA_01179 7.43e-93 yqjT - - E - - - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_01181 2.04e-289 yqjV - - G - - - Major Facilitator Superfamily
MANCPEPA_01183 3.45e-303 polYB 2.7.7.7 - L ko:K02346,ko:K03502 - ko00000,ko01000,ko03400 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MANCPEPA_01184 9.27e-66 yqiX - - S - - - YolD-like protein
MANCPEPA_01185 3.16e-112 yqjY - - K ko:K06977 - ko00000 acetyltransferase
MANCPEPA_01186 2.25e-78 yqjZ - - S - - - enzyme involved in biosynthesis of extracellular polysaccharides
MANCPEPA_01187 5.59e-249 yqkA - - K - - - GrpB protein
MANCPEPA_01188 6.17e-73 yqkB - - S - - - Belongs to the HesB IscA family
MANCPEPA_01189 1.12e-53 yqkC - - S - - - Protein of unknown function (DUF2552)
MANCPEPA_01190 1.38e-223 yqkD - - S ko:K06889 - ko00000 COG1073 Hydrolases of the alpha beta superfamily
MANCPEPA_01191 6.61e-26 yqkE - - S - - - Protein of unknown function (DUF3886)
MANCPEPA_01192 4.4e-216 yqkF - - C - - - oxidoreductases (related to aryl-alcohol dehydrogenases)
MANCPEPA_01193 9.6e-09 - - - S - - - Protein of unknown function (DUF3936)
MANCPEPA_01194 2.87e-120 nudF 3.6.1.13 - L ko:K01515 ko00230,map00230 ko00000,ko00001,ko01000 Belongs to the Nudix hydrolase family
MANCPEPA_01195 1.19e-279 yqxK - - L - - - DNA helicase
MANCPEPA_01196 3.18e-77 ansR - - K - - - Transcriptional regulator
MANCPEPA_01197 1.77e-238 ansA 3.5.1.1 - EJ ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 ko00000,ko00001,ko01000 L-asparaginase
MANCPEPA_01198 0.0 aspA 4.3.1.1 - E ko:K01744 ko00250,ko01100,map00250,map01100 ko00000,ko00001,ko01000 Aspartate ammonia-lyase
MANCPEPA_01199 8.88e-317 mleN - - C ko:K03315 - ko00000,ko02000 Na H antiporter
MANCPEPA_01200 3.95e-309 mleA 1.1.1.38 - C ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 ko00000,ko00001,ko01000 malic enzyme
MANCPEPA_01201 7.27e-42 yqkK - - - - - - -
MANCPEPA_01202 1.96e-139 spoIIM - - S ko:K06384 - ko00000 Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
MANCPEPA_01203 2.26e-104 fur - - P ko:K03711 - ko00000,ko03000 Belongs to the Fur family
MANCPEPA_01204 2.25e-49 - - - S - - - Protein of unknown function (DUF4227)
MANCPEPA_01205 3.91e-214 xerD - - L ko:K04763 - ko00000,ko03036 recombinase XerD
MANCPEPA_01206 6.8e-294 deoB 5.4.2.7 - G ko:K01839 ko00030,ko00230,map00030,map00230 ko00000,ko00001,ko01000 Phosphotransfer between the C1 and C5 carbon atoms of pentose
MANCPEPA_01207 3.98e-190 punA 2.4.2.1, 2.4.2.28 - F ko:K00772,ko:K03783 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 ko00000,ko00001,ko00002,ko01000 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MANCPEPA_01208 5.82e-272 dacF 3.4.16.4 - M ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Belongs to the peptidase S11 family
MANCPEPA_01209 1.98e-76 spoIIAA - - T ko:K06378 - ko00000 Belongs to the anti-sigma-factor antagonist family
MANCPEPA_01210 6.78e-100 spoIIAB 2.7.11.1 - F ko:K06379 - ko00000,ko01000 Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
MANCPEPA_01211 1.18e-174 sigF - - K ko:K03091 - ko00000,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_01212 1.15e-143 spoVAA - - S ko:K06403 - ko00000 Stage V sporulation protein AA
MANCPEPA_01213 5.43e-90 spoVAB - - S ko:K06404 - ko00000 Stage V sporulation protein AB
MANCPEPA_01214 6.71e-102 spoVAC - - S ko:K06405 - ko00000 stage V sporulation protein AC
MANCPEPA_01215 6.02e-246 spoVAD - - I ko:K06406 - ko00000 Stage V sporulation protein AD
MANCPEPA_01216 2.15e-75 spoVAEB - - S ko:K06407 - ko00000 stage V sporulation protein
MANCPEPA_01217 7.54e-143 - - - S ko:K06407 - ko00000 stage V sporulation protein
MANCPEPA_01218 0.0 spoVAF - - EG ko:K06408 - ko00000 Stage V sporulation protein AF
MANCPEPA_01219 0.0 lysA 4.1.1.20 - E ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MANCPEPA_01220 6.29e-192 ypuA - - S - - - Secreted protein
MANCPEPA_01221 1.23e-105 ppiB 5.2.1.8 - O ko:K03768 - ko00000,ko01000,ko03110 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MANCPEPA_01226 2.61e-34 ppiB 5.2.1.8 - O ko:K03768 - ko00000,ko01000,ko03110 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MANCPEPA_01228 3.02e-44 ypzJ - - S ko:K07069 - ko00000 nucleic-acid-binding protein containing a Zn-ribbon domain
MANCPEPA_01229 3.39e-132 lepB 3.4.21.89 - U ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Belongs to the peptidase S26 family
MANCPEPA_01230 5.98e-72 ypuD - - - - - - -
MANCPEPA_01231 7.21e-261 ribD 1.1.1.193, 3.5.4.26 - H ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 ko00000,ko00001,ko00002,ko01000 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MANCPEPA_01232 2.5e-147 ribE 2.5.1.9 - H ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Riboflavin synthase
MANCPEPA_01233 1.48e-290 ribBA 3.5.4.25, 4.1.99.12 - H ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MANCPEPA_01234 8.41e-107 ribH 2.5.1.78 - H ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MANCPEPA_01235 1.12e-83 ribT - - K ko:K02859 - ko00000 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_01236 2.06e-119 ypuF - - S ko:K09763 - ko00000 Domain of unknown function (DUF309)
MANCPEPA_01237 4.45e-166 scpA - - D ko:K05896 - ko00000,ko03036 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MANCPEPA_01238 2.85e-135 scpB - - D ko:K06024 - ko00000,ko03036 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MANCPEPA_01239 2.92e-126 ypuI - - S - - - Protein of unknown function (DUF3907)
MANCPEPA_01240 4.11e-273 dacB 3.4.16.4 - M ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Belongs to the peptidase S11 family
MANCPEPA_01241 7.57e-135 spmA - - S ko:K06373 - ko00000 Spore maturation protein
MANCPEPA_01242 8.62e-114 spmB - - S ko:K06374 - ko00000 Spore maturation protein
MANCPEPA_01243 4.45e-169 rluB 5.4.99.22 - J ko:K06178 - ko00000,ko01000,ko03009 Belongs to the pseudouridine synthase RsuA family
MANCPEPA_01244 1.5e-128 resA - - CO - - - Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
MANCPEPA_01245 0.0 resB - - O ko:K07399 - ko00000 COG1333 ResB protein required for cytochrome c biosynthesis
MANCPEPA_01246 1.34e-278 resC - - O - - - 'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
MANCPEPA_01247 1.97e-170 resD - - T ko:K07775 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_01248 0.0 resE 2.7.13.3 - T ko:K07651 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_01249 1.08e-133 sigX - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_01250 4.91e-246 rsiX - - - - - - -
MANCPEPA_01251 4.79e-174 aroD 4.2.1.10 - E ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
MANCPEPA_01252 0.0 serA 1.1.1.399, 1.1.1.95 - E ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MANCPEPA_01253 3.07e-122 ribU - - U - - - Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MANCPEPA_01254 8.35e-55 fer - - C ko:K05337 - ko00000 Ferredoxin
MANCPEPA_01255 6.62e-257 ypbB 5.1.3.1 - S ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 protein conserved in bacteria
MANCPEPA_01256 0.0 recQ 3.6.4.12 - L ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 DNA helicase
MANCPEPA_01257 6.13e-129 ypbD - - S ko:K07052 - ko00000 metal-dependent membrane protease
MANCPEPA_01258 8.27e-143 ypbE - - M - - - Lysin motif
MANCPEPA_01259 4.08e-106 ypbF - - S - - - Protein of unknown function (DUF2663)
MANCPEPA_01260 6.15e-188 ypbG - - S ko:K07098 - ko00000 Calcineurin-like phosphoesterase superfamily domain
MANCPEPA_01261 5.56e-136 mecB - - NOT ko:K16511 - ko00000 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MANCPEPA_01262 1.42e-308 gudB 1.4.1.2 - E ko:K00260 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 ko00000,ko00001,ko01000 Belongs to the Glu Leu Phe Val dehydrogenases family
MANCPEPA_01263 2.68e-226 ypdA 1.8.1.9 - O ko:K00384 ko00450,map00450 ko00000,ko00001,ko01000 COG0492 Thioredoxin reductase
MANCPEPA_01264 1.76e-153 prsW - - S - - - Involved in the degradation of specific anti-sigma factors
MANCPEPA_01265 6.93e-208 sleB 3.5.1.28 - M ko:K01449 - ko00000,ko01000 Spore cortex-lytic enzyme
MANCPEPA_01266 0.0 ypeB - - H ko:K06313 - ko00000 sporulation protein
MANCPEPA_01267 1.88e-143 ypfA - - M - - - Flagellar protein YcgR
MANCPEPA_01268 1.74e-32 - - - S - - - Family of unknown function (DUF5359)
MANCPEPA_01269 5.8e-146 cmk 2.7.4.25 - F ko:K00945 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the cytidylate kinase family. Type 1 subfamily
MANCPEPA_01270 7.8e-262 rpsA - - J ko:K02945 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Ribosomal protein S1
MANCPEPA_01271 6.91e-237 fni 5.3.3.2 - C ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MANCPEPA_01272 1.13e-11 - - - S - - - YpzI-like protein
MANCPEPA_01273 2.73e-134 yphA - - - - - - -
MANCPEPA_01274 4.35e-207 yphB - - S ko:K05739 - ko00000 YIEGIA protein
MANCPEPA_01275 2.06e-38 ypzH - - - - - - -
MANCPEPA_01276 4.77e-316 der - - S ko:K03977 - ko00000,ko03009 GTPase that plays an essential role in the late steps of ribosome biogenesis
MANCPEPA_01277 4.05e-243 gpsA 1.1.1.94 - I ko:K00057 ko00564,ko01110,map00564,map01110 ko00000,ko00001,ko01000 Glycerol-3-phosphate dehydrogenase
MANCPEPA_01278 7.09e-27 yphE - - S - - - Protein of unknown function (DUF2768)
MANCPEPA_01279 1.5e-176 yphF - - - - - - -
MANCPEPA_01280 0.0 spoIVA - - S ko:K06398 - ko00000 ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MANCPEPA_01281 1.07e-57 hbs - - L ko:K03530 - ko00000,ko03032,ko03036,ko03400 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MANCPEPA_01282 4.41e-131 folE 3.5.4.16 - H ko:K01495 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 GTP cyclohydrolase
MANCPEPA_01283 5.13e-46 mtrB - - K ko:K06285 - ko00000,ko03000 Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
MANCPEPA_01284 8.72e-178 hepS 2.5.1.30 - H ko:K00805 ko00900,ko01110,map00900,map01110 ko00000,ko00001,ko01000,ko01006 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
MANCPEPA_01285 1.34e-169 menG 2.1.1.163, 2.1.1.201 - H ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MANCPEPA_01286 4.09e-249 hepT 2.5.1.30, 2.5.1.83 - H ko:K00805,ko:K21275 ko00900,ko01110,map00900,map01110 ko00000,ko00001,ko01000,ko01006 Belongs to the FPP GGPP synthase family
MANCPEPA_01287 2.17e-104 ndk 2.7.4.6 - F ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 ko00000,ko00001,ko00002,ko01000,ko04131 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MANCPEPA_01288 3.69e-183 cheR 2.1.1.80 - NT ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 COG1352 Methylase of chemotaxis methyl-accepting proteins
MANCPEPA_01289 2.91e-277 aroC 4.2.3.5 - E ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MANCPEPA_01290 3.17e-260 aroB 4.2.3.4 - E ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MANCPEPA_01291 9.82e-84 aroH 5.4.99.5 - E ko:K06208 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
MANCPEPA_01292 0.0 trpE 4.1.3.27 - EH ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 ko00000,ko00001,ko00002,ko01000 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MANCPEPA_01293 2.03e-228 trpD 2.4.2.18, 4.1.3.27 - E ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MANCPEPA_01294 4.18e-145 trpC 4.1.1.48, 5.3.1.24 - E ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the TrpC family
MANCPEPA_01295 3.04e-148 trpF 5.3.1.24 - E ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the TrpF family
MANCPEPA_01296 1.09e-293 trpB 4.2.1.20, 5.3.1.24 - E ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MANCPEPA_01297 3.14e-185 trpA 4.2.1.20 - E ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MANCPEPA_01298 2.6e-258 hisC 2.6.1.9 - E ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MANCPEPA_01299 1.21e-264 tyrA 1.3.1.12 - E ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 prephenate dehydrogenase
MANCPEPA_01300 1.64e-300 aroA 2.5.1.19 - E ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MANCPEPA_01301 5.27e-299 ypiA - - S - - - COG0457 FOG TPR repeat
MANCPEPA_01302 1.29e-129 ypiB - - S - - - Belongs to the UPF0302 family
MANCPEPA_01303 4.75e-101 ypiF - - S - - - Protein of unknown function (DUF2487)
MANCPEPA_01304 3.35e-126 qcrA - - C ko:K03886 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 Menaquinol-cytochrome c reductase
MANCPEPA_01305 8.76e-166 qcrB - - C ko:K03887 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002 COG1290 Cytochrome b subunit of the bc complex
MANCPEPA_01306 5.71e-191 qcrC - - C ko:K03888 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002 Menaquinol-cytochrome c reductase cytochrome b c subunit
MANCPEPA_01307 2.82e-126 ypjA - - S - - - membrane
MANCPEPA_01308 6.84e-183 ypjB - - S - - - sporulation protein
MANCPEPA_01309 3.7e-200 ypjC - - S - - - Uncharacterized protein conserved in bacteria (DUF2179)
MANCPEPA_01310 1.01e-73 ypjD - - S - - - Nucleotide pyrophosphohydrolase
MANCPEPA_01311 2.4e-189 dapB 1.17.1.8 - E ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MANCPEPA_01312 1.52e-94 mgsA 4.2.3.3 - G ko:K01734 ko00640,ko01120,map00640,map01120 ko00000,ko00001,ko01000 methylglyoxal synthase
MANCPEPA_01313 6.61e-167 bshB1 - - S ko:K01463 - ko00000,ko01000 proteins, LmbE homologs
MANCPEPA_01314 8.18e-266 bshA - GT4 M ko:K00754 - ko00000,ko01000 N-acetyl-alpha-D-glucosaminyl L-malate synthase
MANCPEPA_01315 2.5e-277 cca 2.7.7.72 - J ko:K00974 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MANCPEPA_01316 1.98e-233 birA 6.3.4.15 - K ko:K03524 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko01000,ko03000 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MANCPEPA_01317 5.66e-193 panB 2.1.2.11 - H ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MANCPEPA_01318 5.47e-200 panC 6.3.2.1 - H ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MANCPEPA_01319 4.16e-85 panD 4.1.1.11 - H ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MANCPEPA_01320 0.0 dinG 3.6.4.12 - L ko:K03722 - ko00000,ko01000,ko03400 helicase involved in DNA repair and perhaps also replication
MANCPEPA_01321 1.52e-32 ypmA - - S - - - Protein of unknown function (DUF4264)
MANCPEPA_01322 2.27e-103 ypmB - - S - - - protein conserved in bacteria
MANCPEPA_01323 4.37e-285 aspB 2.6.1.1, 2.6.1.14 - E ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko01000,ko01007 Aminotransferase
MANCPEPA_01324 0.0 asnS 6.1.1.22 - J ko:K01893 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 asparaginyl-tRNA
MANCPEPA_01325 2.22e-163 dnaD - - L ko:K02086 - ko00000 DNA replication protein DnaD
MANCPEPA_01326 3.57e-158 nth 4.2.99.18 - L ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MANCPEPA_01327 6.79e-120 ypoC - - - - - - -
MANCPEPA_01328 0.0 ponA 2.4.1.129, 3.4.16.4 GT51 M ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 penicillin-binding protein
MANCPEPA_01329 6.46e-150 recU - - L ko:K03700 - ko00000,ko03400 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MANCPEPA_01330 6.19e-239 yppC - - S - - - Protein of unknown function (DUF2515)
MANCPEPA_01333 7.14e-11 yppE - - S - - - Bacterial domain of unknown function (DUF1798)
MANCPEPA_01334 9.21e-11 - - - S - - - YppF-like protein
MANCPEPA_01335 1.45e-66 yppG - - S - - - YppG-like protein
MANCPEPA_01336 5.06e-94 hspX - - O ko:K06335,ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Belongs to the small heat shock protein (HSP20) family
MANCPEPA_01337 5.3e-110 ypqE - - G ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 ko00000,ko00001,ko00002,ko01000,ko02000 COG2190 Phosphotransferase system IIA components
MANCPEPA_01338 0.0 yprA - - L ko:K06877 - ko00000 COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
MANCPEPA_01339 2.07e-300 yprB - - L ko:K07502 - ko00000 RNase_H superfamily
MANCPEPA_01340 9.4e-128 ypsA - - S - - - Belongs to the UPF0398 family
MANCPEPA_01341 2.97e-60 gpsB - - D - - - Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MANCPEPA_01342 2.84e-286 ypsC - - L ko:K07444 - ko00000,ko01000 Belongs to the methyltransferase superfamily
MANCPEPA_01344 0.0 ypvA 3.6.4.12 - KL ko:K03722 - ko00000,ko01000,ko03400 COG1199 Rad3-related DNA helicases
MANCPEPA_01345 4.44e-174 kduD 1.1.1.127 - IQ ko:K00065 ko00040,map00040 ko00000,ko00001,ko01000 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_01346 2.96e-203 kduI 5.3.1.17 - G ko:K01815 ko00040,map00040 ko00000,ko00001,ko01000 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MANCPEPA_01347 3.18e-237 kdgR - - K ko:K02525 - ko00000,ko03000 transcriptional
MANCPEPA_01348 2.83e-237 kdgK 2.7.1.45 - G ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 COG0524 Sugar kinases, ribokinase family
MANCPEPA_01349 1.2e-131 kdgA 4.1.2.14, 4.1.3.42 - G ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 2-dehydro-3-deoxy-phosphogluconate aldolase
MANCPEPA_01350 4.09e-224 kdgT - - P ko:K02526 - ko00000,ko02000 The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
MANCPEPA_01351 0.0 ypwA 3.4.17.19 - E ko:K01299 - ko00000,ko01000,ko01002 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MANCPEPA_01352 1.65e-128 xpt 2.4.2.22 - F ko:K03816 ko00230,ko01100,ko01110,map00230,map01100,map01110 ko00000,ko00001,ko01000 Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MANCPEPA_01353 3.51e-291 pbuX - - F ko:K03458,ko:K16169,ko:K16170 - ko00000,ko02000 xanthine
MANCPEPA_01354 2.63e-265 bcsA - - Q ko:K16167 - ko00000,ko01008 Naringenin-chalcone synthase
MANCPEPA_01355 9.54e-113 ypbQ - - S ko:K16168 - ko00000,ko01008 protein conserved in bacteria
MANCPEPA_01356 0.0 ypbR - - S - - - Dynamin family
MANCPEPA_01357 2.76e-50 ypbS - - S - - - Protein of unknown function (DUF2533)
MANCPEPA_01358 1.08e-11 - - - - - - - -
MANCPEPA_01359 2.26e-213 ypcP - - L - - - 5'3' exonuclease
MANCPEPA_01360 5.23e-05 - - - - ko:K06429 - ko00000 -
MANCPEPA_01361 6.28e-87 rnhA 3.1.26.4 - L ko:K03469 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Ribonuclease
MANCPEPA_01362 3.27e-136 ypdP - - S ko:K09125 - ko00000 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MANCPEPA_01363 1.9e-161 ypeP 3.1.26.4 - L ko:K03469 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 COG0328 Ribonuclease HI
MANCPEPA_01364 7.99e-41 ypeQ - - S - - - Zinc-finger
MANCPEPA_01365 1.05e-40 - - - S - - - Protein of unknown function (DUF2564)
MANCPEPA_01366 1.17e-22 degR - - - - - - -
MANCPEPA_01367 2.54e-42 cspD - - K ko:K03704 - ko00000,ko03000 Cold-shock protein
MANCPEPA_01368 1.28e-276 ugtP 2.4.1.315 GT28 M ko:K03429 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko01000,ko01003 Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
MANCPEPA_01369 1.49e-225 metAA 2.3.1.46 - E ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MANCPEPA_01370 7.69e-115 bsaA 1.11.1.9 - O ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 ko00000,ko00001,ko01000 Belongs to the glutathione peroxidase family
MANCPEPA_01371 2.6e-135 yagB - - S ko:K06950 - ko00000 phosphohydrolase
MANCPEPA_01372 2.83e-204 ypgR - - C - - - COG0694 Thioredoxin-like proteins and domains
MANCPEPA_01373 0.0 ilvD 4.2.1.9 - E ko:K01687,ko:K16786 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Belongs to the IlvD Edd family
MANCPEPA_01374 9.69e-99 yphP - - S - - - Belongs to the UPF0403 family
MANCPEPA_01375 2.81e-183 ypiP - - AJ - - - Putative SAM-dependent methyltransferase
MANCPEPA_01376 1.16e-146 ypjP - - S - - - YpjP-like protein
MANCPEPA_01377 8.91e-121 ltrC 3.1.3.27 - I ko:K01095 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 COG1267 Phosphatidylglycerophosphatase A and related proteins
MANCPEPA_01378 9.52e-199 thyA 2.1.1.45 - F ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko00000,ko00001,ko00002,ko01000 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MANCPEPA_01379 9.58e-122 dfrA 1.5.1.3 - H ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 ko00000,ko00001,ko00002,ko01000 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MANCPEPA_01380 8.12e-144 ypkP 2.3.1.51 - I ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01004 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MANCPEPA_01381 8.03e-143 yplQ - - S ko:K11068 - ko00000,ko02042 protein, Hemolysin III
MANCPEPA_01382 1.4e-236 yplP - - K - - - Transcriptional regulator
MANCPEPA_01383 7.04e-308 ilvA 4.3.1.19 - E ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MANCPEPA_01384 1.28e-54 ypmP - - S - - - Protein of unknown function (DUF2535)
MANCPEPA_01385 3.23e-139 ypmQ - - S ko:K07152 - ko00000,ko03029 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
MANCPEPA_01386 1.05e-177 ypmR - - E - - - GDSL-like Lipase/Acylhydrolase
MANCPEPA_01387 6.8e-129 ypmS - - S - - - protein conserved in bacteria
MANCPEPA_01388 2.13e-40 ypmT - - S - - - Uncharacterized ympT
MANCPEPA_01389 1.65e-288 mepA - - V - - - MATE efflux family protein
MANCPEPA_01390 4.14e-94 ypoP - - K - - - transcriptional
MANCPEPA_01391 1.63e-131 msrB 1.8.4.11, 1.8.4.12 - O ko:K07304,ko:K12267 - ko00000,ko01000 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MANCPEPA_01392 7.13e-103 msrB 1.8.4.12 - O ko:K07305 - ko00000,ko01000 peptide methionine sulfoxide reductase
MANCPEPA_01393 8.25e-158 - - - GM ko:K19421 - ko00000 Polysaccharide biosynthesis protein
MANCPEPA_01394 1.1e-277 phy 3.1.3.8 - I ko:K01083 ko00562,map00562 ko00000,ko00001,ko01000 Myo-inositol-hexaphosphate 3-phosphohydrolase
MANCPEPA_01395 3.86e-236 cgeB - - S ko:K06320 - ko00000 Spore maturation protein
MANCPEPA_01396 1.12e-85 cgeA - - - ko:K06319 - ko00000 -
MANCPEPA_01397 3.04e-59 cgeC - - - ko:K06321 - ko00000 -
MANCPEPA_01398 0.0 cgeD - - M ko:K06322 - ko00000 maturation of the outermost layer of the spore
MANCPEPA_01399 9.39e-183 yiiD - - K ko:K06323 - ko00000 acetyltransferase
MANCPEPA_01401 0.0 yodT - - H - - - Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MANCPEPA_01402 3.41e-161 atoD 2.8.3.8, 2.8.3.9 - I ko:K01034 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 ko00000,ko00001,ko01000 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MANCPEPA_01403 5.46e-152 atoA 2.8.3.8, 2.8.3.9 - I ko:K01035 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 ko00000,ko00001,ko01000 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MANCPEPA_01404 0.0 yodQ 3.5.1.16, 3.5.1.18 - E ko:K01438,ko:K01439 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Acetylornithine deacetylase
MANCPEPA_01405 1.84e-197 yodP 2.3.1.264 - K ko:K21935 - ko00000,ko01000 Acetyltransferase (GNAT) family
MANCPEPA_01406 0.0 kamA 5.4.3.2 - E ko:K01843 ko00310,map00310 ko00000,ko00001,ko01000 lysine 2,3-aminomutase
MANCPEPA_01407 1.4e-62 yokU - - S - - - YokU-like protein, putative antitoxin
MANCPEPA_01408 7.3e-50 yozE - - S - - - Belongs to the UPF0346 family
MANCPEPA_01409 1.29e-159 yodN - - - - - - -
MANCPEPA_01411 5.18e-34 yozD - - S - - - YozD-like protein
MANCPEPA_01412 6.67e-137 yodM 3.6.1.27 - I ko:K19302 ko00550,map00550 ko00000,ko00001,ko01000,ko01011 Acid phosphatase homologues
MANCPEPA_01413 1.17e-71 yodL - - S - - - YodL-like
MANCPEPA_01414 2.08e-12 - - - - - - - -
MANCPEPA_01415 1.68e-163 deoD 2.4.2.1 - F ko:K03784 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko00000,ko00001,ko01000 Purine nucleoside phosphorylase
MANCPEPA_01416 1.33e-189 yodJ 3.4.17.14 - M ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 D-alanyl-D-alanine carboxypeptidase
MANCPEPA_01417 2.93e-42 yodI - - - - - - -
MANCPEPA_01418 3.69e-167 yodH - - Q - - - Methyltransferase
MANCPEPA_01419 0.0 ctpA 3.4.21.102 - M ko:K03797 - ko00000,ko01000,ko01002 Belongs to the peptidase S41A family
MANCPEPA_01420 0.0 yodF - - E ko:K03307 - ko00000 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANCPEPA_01421 2.36e-38 - - - S - - - Protein of unknown function (DUF3311)
MANCPEPA_01422 3.38e-223 yodE - - E ko:K15975 - ko00000 COG0346 Lactoylglutathione lyase and related lyases
MANCPEPA_01423 3.76e-146 yahD - - S ko:K06999 - ko00000 Carboxylesterase
MANCPEPA_01424 1.92e-140 yodC - - C - - - nitroreductase
MANCPEPA_01425 2.63e-73 yodB - - K - - - transcriptional
MANCPEPA_01426 2.3e-83 iolK - - S - - - tautomerase
MANCPEPA_01427 9.24e-290 gntP - - EG ko:K03299 - ko00000,ko02000 COG2610 H gluconate symporter and related permeases
MANCPEPA_01428 1.95e-14 - - - - - - - -
MANCPEPA_01429 1.89e-100 yozR - - S - - - COG0071 Molecular chaperone (small heat shock protein)
MANCPEPA_01430 5.49e-206 rarD - - S ko:K05786 - ko00000,ko02000 -transporter
MANCPEPA_01431 1.52e-57 - - - - - - - -
MANCPEPA_01432 2.32e-79 yojF - - S - - - Protein of unknown function (DUF1806)
MANCPEPA_01433 2.61e-161 yojG - - S ko:K22135 - ko00000,ko01000 deacetylase
MANCPEPA_01434 2.1e-186 - - - T ko:K17763 - ko00000,ko03021 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MANCPEPA_01435 4.64e-310 norM - - V ko:K03327 - ko00000,ko02000 Multidrug efflux pump
MANCPEPA_01437 2.91e-139 dacB 2.7.7.85 - S ko:K18672 - ko00000,ko01000 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MANCPEPA_01438 3.34e-286 yojK - - CG - - - UDP-glucoronosyl and UDP-glucosyl transferase
MANCPEPA_01439 1.02e-264 - - CBM50 M ko:K19220,ko:K19223,ko:K19224 - ko00000,ko01000,ko01002,ko01011 COG1388 FOG LysM repeat
MANCPEPA_01440 6.01e-141 sodC 1.15.1.1 - P ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko00000,ko00001,ko01000 Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MANCPEPA_01441 8.98e-206 yojN - - S ko:K04748 - ko00000 ATPase family associated with various cellular activities (AAA)
MANCPEPA_01442 0.0 yojO - - P - - - Von Willebrand factor
MANCPEPA_01443 0.0 odhA 1.2.4.2 - C ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
MANCPEPA_01444 3.16e-265 odhB 2.3.1.61 - C ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
MANCPEPA_01445 3.31e-214 yocS - - S ko:K03453 - ko00000 -transporter
MANCPEPA_01446 2.41e-297 yocR - - S ko:K03308 - ko00000 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MANCPEPA_01447 6.23e-208 sodF 1.15.1.1 - P ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Superoxide dismutase
MANCPEPA_01448 0.0 sqhC 4.2.1.137 - I ko:K18115 - ko00000,ko01000 COG1657 Squalene cyclase
MANCPEPA_01449 0.0 dhaS 1.2.1.3, 1.2.1.39 - C ko:K00128,ko:K00146 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the aldehyde dehydrogenase family
MANCPEPA_01450 1.91e-42 yozC - - - - - - -
MANCPEPA_01451 2.17e-74 yozO - - S - - - Bacterial PH domain
MANCPEPA_01452 1.83e-49 yocN - - - - - - -
MANCPEPA_01453 2.94e-55 yozN - - - - - - -
MANCPEPA_01454 3.15e-113 yocM - - O ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Belongs to the small heat shock protein (HSP20) family
MANCPEPA_01455 3.93e-41 - - - - - - - -
MANCPEPA_01456 1.75e-69 yocL - - - - - - -
MANCPEPA_01457 2.87e-107 yocK - - T - - - general stress protein
MANCPEPA_01458 1.46e-147 azoR - - I ko:K01118 - ko00000,ko01000 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MANCPEPA_01459 0.0 recQ 3.6.4.12 - L ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 DNA helicase
MANCPEPA_01460 2.89e-175 yocH - - M - - - COG1388 FOG LysM repeat
MANCPEPA_01461 4.71e-135 desR - - T ko:K02479,ko:K07693 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_01462 2.88e-251 desK 2.7.13.3 - T ko:K07778 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_01463 1.34e-256 des 1.14.19.23, 1.14.19.45 - I ko:K10255 ko02020,map02020 ko00000,ko00001,ko01000,ko01004 fatty acid desaturase
MANCPEPA_01464 1.58e-239 yocD 3.4.17.13 - V ko:K01297 - ko00000,ko01000,ko01002,ko01011 peptidase S66
MANCPEPA_01465 1.08e-121 yocC - - - - - - -
MANCPEPA_01466 2.6e-185 - - - - - - - -
MANCPEPA_01467 3.97e-119 yozB - - S ko:K08976 - ko00000 membrane
MANCPEPA_01468 1.9e-156 yocA - - M - - - COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MANCPEPA_01469 8.12e-69 czrA - - K ko:K22043 - ko00000,ko03000 transcriptional
MANCPEPA_01470 3.01e-120 yobW - - - - - - -
MANCPEPA_01471 1.09e-224 yobV - - K - - - WYL domain
MANCPEPA_01472 8.64e-112 - - - K - - - Bacterial transcription activator, effector binding domain
MANCPEPA_01473 1.29e-167 yobT - - S - - - COG0491 Zn-dependent hydrolases, including glyoxylases
MANCPEPA_01474 3.09e-127 yobS - - K - - - Transcriptional regulator
MANCPEPA_01475 1.24e-181 - - - J - - - FR47-like protein
MANCPEPA_01476 1.82e-171 yobQ - - K - - - helix_turn_helix, arabinose operon control protein
MANCPEPA_01477 2.04e-68 csaA - - J ko:K06878 - ko00000 tRNA-binding protein
MANCPEPA_01478 0.0 yobO - - M - - - Pectate lyase superfamily protein
MANCPEPA_01479 0.0 iaaM 1.4.3.4 - E ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 ko00000,ko00001,ko00002,ko01000 COG1231 Monoamine oxidase
MANCPEPA_01480 9.75e-133 yokH - - G - - - SMI1 / KNR4 family
MANCPEPA_01481 1.08e-46 - - - L ko:K21487 - ko00000,ko01000,ko02048 A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MANCPEPA_01485 4.99e-08 - - - K - - - Helix-turn-helix
MANCPEPA_01486 6.27e-51 - - - S - - - TM2 domain
MANCPEPA_01487 7.53e-157 xlnB 3.2.1.8 - G ko:K01181 - ko00000,ko01000 Glycosyl hydrolases family 11
MANCPEPA_01488 0.0 pps 2.7.9.2 - GT ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 phosphoenolpyruvate synthase
MANCPEPA_01491 2.54e-215 penP 3.5.2.6 - V ko:K17836,ko:K18766 ko00311,ko01130,ko01501,map00311,map01130,map01501 ko00000,ko00001,ko00002,ko01000,ko01504 beta-lactamase
MANCPEPA_01492 1.7e-147 lin0465 - - S - - - DJ-1/PfpI family
MANCPEPA_01493 3.13e-99 yoaW - - - - - - -
MANCPEPA_01494 1.24e-199 yoaV - - EG - - - EamA-like transporter family
MANCPEPA_01495 7.78e-202 yoaU - - K - - - LysR substrate binding domain
MANCPEPA_01496 7.76e-189 yoaT - - S - - - Protein of unknown function (DUF817)
MANCPEPA_01497 6.07e-49 yozG - - K ko:K07727 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01498 2.65e-97 yoaS - - S - - - Protein of unknown function (DUF2975)
MANCPEPA_01499 1.04e-217 yoaR - - V - - - vancomycin resistance protein
MANCPEPA_01500 2.27e-114 - - - - - - - -
MANCPEPA_01502 1.88e-67 yoaQ - - S - - - Evidence 4 Homologs of previously reported genes of
MANCPEPA_01503 1.91e-183 yoaP - - K - - - YoaP-like
MANCPEPA_01505 8.53e-291 oxdD 4.1.1.2 - G ko:K01569 ko00630,ko01100,map00630,map01100 ko00000,ko00001,ko01000 Oxalate decarboxylase
MANCPEPA_01507 2.42e-169 yoqW - - S - - - Belongs to the SOS response-associated peptidase family
MANCPEPA_01508 2.89e-252 - 4.2.2.10 - G ko:K01732 - ko00000,ko01000 Amb_all
MANCPEPA_01509 1.47e-144 yoaK - - S - - - Membrane
MANCPEPA_01510 2.61e-171 yoaJ - - G ko:K20628 - ko00000 Endoglucanase C-terminal domain subunit and related proteins
MANCPEPA_01511 0.0 yoaI 1.14.14.9 - Q ko:K00483 ko00350,ko01120,ko01220,map00350,map01120,map01220 ko00000,ko00001,ko01000 COG2368 Aromatic ring hydroxylase
MANCPEPA_01512 3.89e-283 yoaH - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 methyl-accepting chemotaxis protein
MANCPEPA_01513 1.13e-59 - - - S - - - Protein of unknown function (DUF4025)
MANCPEPA_01514 1.46e-19 - - - - - - - -
MANCPEPA_01516 2.08e-44 yoaF - - - - - - -
MANCPEPA_01517 0.0 yoaE - - C - - - belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MANCPEPA_01518 7.91e-233 yoaD 1.1.1.399, 1.1.1.95 - EH ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MANCPEPA_01519 0.0 lsrK 2.7.1.189 - G ko:K11216 ko02024,map02024 ko00000,ko00001,ko01000 FGGY family of carbohydrate kinases, C-terminal domain
MANCPEPA_01520 8.38e-298 yoaB - - EGP - - - the major facilitator superfamily
MANCPEPA_01521 6.15e-64 yoaA 2.3.1.128 - J ko:K03790 - ko00000,ko01000,ko03009 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MANCPEPA_01522 6.16e-165 yoxB - - - - - - -
MANCPEPA_01523 9.43e-52 yoxC - - S - - - Bacterial protein of unknown function (DUF948)
MANCPEPA_01524 3.23e-159 fabG 1.1.1.100 - S ko:K00059,ko:K07124 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_01525 5.37e-79 rtp - - K - - - Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
MANCPEPA_01526 3.18e-184 proC 1.5.1.2 - E ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MANCPEPA_01527 3.86e-261 proB 2.7.2.11 - E ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MANCPEPA_01528 2.61e-205 gltC - - K ko:K09681 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01529 0.0 gltA 1.4.1.13, 1.4.1.14, 1.4.7.1 - E ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko01000 glutamate synthase
MANCPEPA_01530 0.0 gltD 1.4.1.13, 1.4.1.14 - E ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko01000 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
MANCPEPA_01531 1.9e-233 yogA - - C ko:K13955 - ko00000 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MANCPEPA_01532 5.67e-197 gltR1 - - K ko:K21959 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01533 0.0 ggt 2.3.2.2, 3.4.19.13 - E ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 ko00000,ko00001,ko01000,ko01002 gamma-glutamyltransferase
MANCPEPA_01534 3.31e-47 yoeD - - G - - - Helix-turn-helix domain
MANCPEPA_01535 1.14e-124 - - - L - - - Integrase
MANCPEPA_01537 2.91e-127 yoeB - - S - - - IseA DL-endopeptidase inhibitor
MANCPEPA_01538 9.8e-313 yoeA - - V - - - MATE efflux family protein
MANCPEPA_01539 5.75e-242 yoxA 5.1.3.3 - G ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Aldose 1-epimerase
MANCPEPA_01540 0.0 dacC 3.4.16.4 - M ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 D-alanyl-D-alanine carboxypeptidase
MANCPEPA_01541 0.0 - - - Q ko:K15664,ko:K15666,ko:K15667 ko01054,map01054 ko00000,ko00001,ko01008 Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_01542 0.0 - 6.3.2.14 - Q ko:K02364,ko:K15656,ko:K15668 ko01053,ko01054,ko01110,ko01130,ko02024,map01053,map01054,map01110,map01130,map02024 ko00000,ko00001,ko01000,ko01008 amino acid activation for nonribosomal peptide biosynthetic process
MANCPEPA_01543 2.12e-84 yngL - - S - - - Protein of unknown function (DUF1360)
MANCPEPA_01544 0.0 yngK - - T - - - Glycosyl hydrolase-like 10
MANCPEPA_01545 5.35e-268 yngJ 1.3.8.1 - I ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 ko00000,ko00001,ko01000 acyl-CoA dehydrogenase
MANCPEPA_01546 0.0 yngI - - IQ ko:K00666 - ko00000,ko01000,ko01004 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MANCPEPA_01547 0.0 yngH 6.3.4.14, 6.4.1.2 - I ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002,ko01000 Biotin carboxylase
MANCPEPA_01548 7.15e-43 - - - I ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko00000,ko00001,ko00002 Biotin carboxyl carrier protein
MANCPEPA_01549 6.73e-212 yngG 4.1.3.4 - E ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 ko00000,ko00001,ko00002,ko01000 Hydroxymethylglutaryl-CoA lyase
MANCPEPA_01550 2.46e-174 yngF - - I - - - Belongs to the enoyl-CoA hydratase isomerase family
MANCPEPA_01551 0.0 yngE - - I - - - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MANCPEPA_01552 1.28e-296 yngD - - S ko:K07097 - ko00000 phosphohydrolase (DHH superfamily)
MANCPEPA_01553 2.01e-134 yngC - - S - - - membrane-associated protein
MANCPEPA_01554 4.54e-209 yngB 2.7.7.9 - M ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko00000,ko00001,ko00002,ko01000 UTP-glucose-1-phosphate uridylyltransferase
MANCPEPA_01555 4.94e-103 yngA - - S - - - membrane
MANCPEPA_01556 0.0 xynD 3.2.1.55 CBM6,GH43 G ko:K15921 ko00520,map00520 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 43 family
MANCPEPA_01557 2.36e-315 ynfF 3.2.1.136 GH5 M ko:K15924 - ko00000,ko01000 Belongs to the glycosyl hydrolase 30 family
MANCPEPA_01559 0.0 bglC5 3.2.1.4 GH5,GH9 G ko:K01179 ko00500,ko01100,map00500,map01100 ko00000,ko00001,ko01000 PFAM glycoside hydrolase family 5
MANCPEPA_01560 0.0 alsT - - E ko:K03310,ko:K11626 ko02020,map02020 ko00000,ko00001 Sodium alanine symporter
MANCPEPA_01561 1.06e-75 ynfC - - - - - - -
MANCPEPA_01562 1.82e-18 - - - - - - - -
MANCPEPA_01563 0.0 parC - - L ko:K02621 - ko00000,ko01000,ko02048,ko03032,ko03036 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MANCPEPA_01564 0.0 parE - - L ko:K02622 - ko00000,ko01000,ko02048,ko03032,ko03036 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MANCPEPA_01565 1.21e-90 yneT - - S ko:K06929 - ko00000 CoA-binding protein
MANCPEPA_01566 5.48e-122 plsY 2.3.1.15 - I ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MANCPEPA_01567 8.97e-65 yneR - - S - - - Belongs to the HesB IscA family
MANCPEPA_01568 5.48e-70 yneQ - - - - - - -
MANCPEPA_01569 5.7e-95 yneP - - S ko:K07107 - ko00000,ko01000 Thioesterase-like superfamily
MANCPEPA_01570 6.62e-48 tlp - - S ko:K06434 - ko00000 Belongs to the Tlp family
MANCPEPA_01572 9.26e-10 - - - S - - - Fur-regulated basic protein B
MANCPEPA_01573 2.53e-118 yneN - - CO - - - alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MANCPEPA_01574 0.0 citB 4.2.1.3 - C ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MANCPEPA_01575 3.75e-21 sspO - - S ko:K06432 - ko00000 Belongs to the SspO family
MANCPEPA_01576 5.65e-27 sspP - - S ko:K06433 - ko00000 Belongs to the SspP family
MANCPEPA_01577 5.77e-85 cotM - - O ko:K06335 - ko00000 Spore coat protein
MANCPEPA_01578 3.97e-97 yneK - - S - - - Protein of unknown function (DUF2621)
MANCPEPA_01579 7.21e-98 yneJ - - O - - - COG4846 Membrane protein involved in cytochrome C biogenesis
MANCPEPA_01580 7.38e-78 ccdB - - T ko:K03413 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko00002,ko02022,ko02035 cheY-homologous receiver domain
MANCPEPA_01581 1.68e-164 ccdA - - O ko:K06196 - ko00000,ko02000 cytochrome c biogenesis protein
MANCPEPA_01582 4.59e-21 ynzD - - S - - - Spo0E like sporulation regulatory protein
MANCPEPA_01583 4.36e-39 yneF - - S ko:K09976 - ko00000 UPF0154 protein
MANCPEPA_01584 2.18e-106 yneE - - S - - - Sporulation inhibitor of replication protein sirA
MANCPEPA_01585 0.0 tkt 2.2.1.1 - G ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MANCPEPA_01586 1.15e-43 ynzC - - S - - - UPF0291 protein
MANCPEPA_01587 2.29e-144 yneB - - L - - - resolvase
MANCPEPA_01588 8.5e-65 yneA - - D - - - Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
MANCPEPA_01589 7.22e-142 lexA 3.4.21.88 - K ko:K01356 - ko00000,ko00002,ko01000,ko01002,ko03400 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MANCPEPA_01590 4.44e-104 fosB - - H ko:K11210,ko:K21252 - ko00000,ko01000,ko01504 Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
MANCPEPA_01591 1.32e-96 yndM - - S - - - Protein of unknown function (DUF2512)
MANCPEPA_01592 3.26e-175 yndL - - S - - - Replication protein
MANCPEPA_01594 0.0 yndJ - - S - - - YndJ-like protein
MANCPEPA_01595 8.49e-150 - - - S - - - Domain of unknown function (DUF4166)
MANCPEPA_01596 2.52e-196 yndG - - S - - - DoxX-like family
MANCPEPA_01597 2.27e-288 - - - S ko:K06293,ko:K06312 - ko00000 Spore germination protein
MANCPEPA_01598 7.36e-75 yndE7 - - U ko:K06311 - ko00000,ko02000 Spore germination
MANCPEPA_01599 2e-156 yndE7 - - U ko:K06311 - ko00000,ko02000 Spore germination
MANCPEPA_01600 2.21e-230 yndD1 - - EG ko:K06288,ko:K06291,ko:K06310 - ko00000 Spore germination protein
MANCPEPA_01601 5.03e-96 yndD1 - - EG ko:K06288,ko:K06291,ko:K06310 - ko00000 Spore germination protein
MANCPEPA_01604 1.05e-102 yndB - - S - - - Activator of Hsp90 ATPase homolog 1-like protein
MANCPEPA_01605 7.34e-95 - - - - - - - -
MANCPEPA_01606 2.37e-34 tatA - - U ko:K03116,ko:K03117,ko:K03646 ko03060,ko03070,map03060,map03070 ko00000,ko00001,ko00002,ko02000,ko02044 protein secretion
MANCPEPA_01609 3.76e-166 - - - S - - - Domain of unknown function, YrpD
MANCPEPA_01611 3.91e-210 - - - S - - - Thymidylate synthase
MANCPEPA_01614 7.54e-22 - - - - - - - -
MANCPEPA_01615 3.01e-102 yncF 3.6.1.23 - F ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 ko00000,ko00001,ko00002,ko01000,ko03400 Deoxyuridine 5'-triphosphate
MANCPEPA_01616 9.48e-108 - - - S - - - Protein of unknown function (DUF2691)
MANCPEPA_01617 2.93e-279 alr 5.1.1.1 - E ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 ko00000,ko00001,ko01000,ko01011 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MANCPEPA_01618 0.0 - - - U ko:K02100,ko:K06609,ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MANCPEPA_01619 7.18e-145 yokF 3.1.31.1 - L ko:K01174 - ko00000,ko01000 RNA catabolic process
MANCPEPA_01620 0.0 xylB 2.7.1.17 - G ko:K00854 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko00002,ko01000 xylulose kinase
MANCPEPA_01621 0.0 xylA 5.3.1.5 - G ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 ko00000,ko00001,ko01000 Belongs to the xylose isomerase family
MANCPEPA_01622 1.18e-273 xylR - - GK - - - ROK family
MANCPEPA_01623 0.0 xynB 3.2.1.37 GH43 G ko:K01198 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 43 family
MANCPEPA_01624 0.0 xynP - - G ko:K03292 - ko00000 MFS/sugar transport protein
MANCPEPA_01625 3.75e-48 - - - S ko:K03824 - ko00000,ko01000 family acetyltransferase
MANCPEPA_01626 2.04e-99 - - - E - - - phosphoribosylanthranilate isomerase activity
MANCPEPA_01629 5.66e-145 - - - S - - - Domain of unknown function (DUF3885)
MANCPEPA_01630 3.39e-31 - - - K ko:K07727 - ko00000,ko03000 Cro/C1-type HTH DNA-binding domain
MANCPEPA_01631 2.38e-11 ywlA - - S - - - Uncharacterised protein family (UPF0715)
MANCPEPA_01632 6.05e-91 - - - S - - - CAAX protease self-immunity
MANCPEPA_01633 2.78e-124 ynaD - - J - - - Acetyltransferase (GNAT) domain
MANCPEPA_01635 1.81e-273 - - - H - - - N-terminal domain of galactosyltransferase
MANCPEPA_01636 1.74e-247 - - - M - - - COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_01637 1.17e-155 - - - H - - - Methionine biosynthesis protein MetW
MANCPEPA_01638 9.6e-120 - - - M - - - Glycosyltransferase like family
MANCPEPA_01639 1.24e-83 - - - Q - - - Collagen triple helix repeat (20 copies)
MANCPEPA_01642 3.06e-14 - - - - - - - -
MANCPEPA_01643 0.0 glnA 6.3.1.2 - E ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 ko00000,ko00001,ko01000,ko04147 glutamine synthetase
MANCPEPA_01644 9.94e-90 glnR - - K ko:K03713,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000,ko03000 transcriptional
MANCPEPA_01645 4.78e-310 ynbB - - P - - - COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
MANCPEPA_01646 7.4e-293 hflX - - S ko:K03665 - ko00000,ko03009 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MANCPEPA_01647 2.29e-226 spoVK - - O ko:K06413 - ko00000 stage V sporulation protein K
MANCPEPA_01648 5.49e-148 cwlC 3.5.1.28 - M ko:K01448 ko01503,map01503 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 n-acetylmuramoyl-L-alanine amidase
MANCPEPA_01649 1.29e-140 - - - - - - - -
MANCPEPA_01650 1.65e-243 nrdF 1.17.4.1 - F ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 ko00000,ko00001,ko00002,ko01000,ko03400 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANCPEPA_01651 0.0 nrdE 1.17.4.1 - F ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 ko00000,ko00001,ko00002,ko01000,ko03400 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANCPEPA_01652 5.01e-66 nrdI - - F ko:K03647 - ko00000 Probably involved in ribonucleotide reductase function
MANCPEPA_01653 7.48e-31 ymzA - - - - - - -
MANCPEPA_01654 1.63e-31 - - - - - - - -
MANCPEPA_01655 1.28e-45 hfq - - J ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 ko00000,ko00001,ko03019,ko03036 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
MANCPEPA_01656 9.69e-224 miaA 2.5.1.75 - J ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 ko00000,ko00001,ko01000,ko01006,ko03016 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MANCPEPA_01657 5.41e-76 ymaF - - S - - - YmaF family
MANCPEPA_01659 2.02e-66 ebrA - - P ko:K11814 - ko00000,ko00002,ko02000 Small Multidrug Resistance protein
MANCPEPA_01660 6.39e-73 ebrB - - P ko:K03297,ko:K11814,ko:K11815 - ko00000,ko00002,ko02000 COG2076 Membrane transporters of cations and cationic drugs
MANCPEPA_01661 5.98e-105 ymaD - - O - - - redox protein, regulator of disulfide bond formation
MANCPEPA_01662 3.96e-163 ymaC - - S - - - Replication protein
MANCPEPA_01664 0.0 aprX - - O ko:K17734 - ko00000,ko01000,ko01002 Belongs to the peptidase S8 family
MANCPEPA_01665 1.27e-205 - - - S - - - Metallo-beta-lactamase superfamily
MANCPEPA_01666 8.03e-81 ymzB - - - - - - -
MANCPEPA_01667 6.85e-295 cypA 1.14.14.46, 1.14.15.13 - C ko:K15468,ko:K16593,ko:K17474 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko00199,ko01000,ko01008 Cytochrome P450
MANCPEPA_01668 0.0 - - - HQ ko:K13615 - ko00000,ko01004,ko01008 Beta-ketoacyl synthase
MANCPEPA_01669 0.0 - - - IQ ko:K13611,ko:K13613,ko:K13614 - ko00000,ko01004,ko01008 polyketide synthase
MANCPEPA_01670 0.0 - - - IQ ko:K13611,ko:K13613,ko:K13614 - ko00000,ko01004,ko01008 polyketide synthase
MANCPEPA_01671 0.0 - - - Q ko:K13612 - ko00000,ko01004,ko01008 Polyketide synthase of type I
MANCPEPA_01672 0.0 - - - IQ ko:K13611,ko:K13613,ko:K13614 - ko00000,ko01004,ko01008 polyketide synthase
MANCPEPA_01673 2.69e-177 pksI - - I ko:K15313 - ko00000,ko01008 Belongs to the enoyl-CoA hydratase isomerase family
MANCPEPA_01674 2.48e-184 - - - I ko:K15312 - ko00000,ko01008 enoyl-CoA hydratase
MANCPEPA_01675 9.7e-314 pksG 2.3.3.10 - I ko:K01641,ko:K15311 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000,ko01008 synthase
MANCPEPA_01676 5.31e-304 - 2.3.1.179 - I ko:K00646,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MANCPEPA_01677 5.46e-51 acpK - - IQ ko:K15337 - ko00000,ko01008 Phosphopantetheine attachment site
MANCPEPA_01678 0.0 fabD 2.3.1.39 - I ko:K00645,ko:K15327,ko:K15329 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 malonyl CoA-acyl carrier protein transacylase
MANCPEPA_01679 2.42e-238 pksD - - Q ko:K15328 - ko00000,ko01008 Acyl transferase domain
MANCPEPA_01680 4.37e-207 fabD 2.3.1.39 - I ko:K00645,ko:K15327,ko:K15329 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 malonyl CoA-acyl carrier protein transacylase
MANCPEPA_01681 6.66e-166 pksB 3.1.2.6 - S ko:K01069 ko00620,map00620 ko00000,ko00001,ko01000 Polyketide biosynthesis
MANCPEPA_01682 2.94e-141 pksA - - K - - - Transcriptional regulator
MANCPEPA_01683 6.55e-126 ymcC - - S - - - Membrane
MANCPEPA_01684 2.72e-91 - - - S - - - Regulatory protein YrvL
MANCPEPA_01686 0.0 mutL - - L ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MANCPEPA_01687 0.0 mutS - - L ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MANCPEPA_01688 1.74e-119 cotE - - S ko:K06328 - ko00000 Spore coat protein
MANCPEPA_01689 1.27e-89 ymcA 3.6.3.21 - S ko:K02028 - ko00000,ko00002,ko01000,ko02000 Belongs to the UPF0342 family
MANCPEPA_01690 0.0 miaB 2.8.4.3 - J ko:K06168 - ko00000,ko01000,ko03016 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MANCPEPA_01691 5.89e-278 kbl 2.3.1.29, 2.3.1.47 - H ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 ko00000,ko00001,ko00002,ko01000,ko01007 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MANCPEPA_01692 1.44e-253 tdh 1.1.1.103 - C ko:K00060 ko00260,map00260 ko00000,ko00001,ko01000 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
MANCPEPA_01693 2.44e-49 spoVS - - S ko:K06416 - ko00000 Stage V sporulation protein S
MANCPEPA_01694 6.18e-195 ymdB - - S ko:K02029,ko:K02030,ko:K09769 - ko00000,ko00002,ko02000 protein conserved in bacteria
MANCPEPA_01695 4.25e-306 rny - - S ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Endoribonuclease that initiates mRNA decay
MANCPEPA_01696 9.84e-281 pbpX - - V - - - Beta-lactamase
MANCPEPA_01697 4.7e-239 recA - - L ko:K03553 ko03440,map03440 ko00000,ko00001,ko00002,ko03400 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MANCPEPA_01698 7.49e-300 cinA 3.5.1.42 - S ko:K03742,ko:K03743 ko00760,map00760 ko00000,ko00001,ko01000 Belongs to the CinA family
MANCPEPA_01699 3.34e-132 pgsA 2.7.8.5 - I ko:K00995 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MANCPEPA_01700 3.05e-177 ymfM - - S ko:K15539 - ko00000 protein conserved in bacteria
MANCPEPA_01701 3.91e-183 ymfK - - S - - - Protein of unknown function (DUF3388)
MANCPEPA_01702 5.13e-55 ymfJ - - S - - - Protein of unknown function (DUF3243)
MANCPEPA_01703 2.58e-167 ymfI 1.1.1.100 - S ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
MANCPEPA_01704 5.35e-306 ymfH - - S - - - zinc protease
MANCPEPA_01705 4.7e-299 albE - - S - - - Peptidase M16
MANCPEPA_01706 7.54e-266 ymfD - - EGP ko:K08221 - ko00000,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_01707 1.28e-171 ymfC - - K ko:K03710 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01708 0.0 ftsK - - D ko:K03466 - ko00000,ko03036 Belongs to the FtsK SpoIIIE SftA family
MANCPEPA_01709 4.94e-44 - - - S - - - YlzJ-like protein
MANCPEPA_01710 5.01e-171 tepA - - OU - - - COG0740 Protease subunit of ATP-dependent Clp proteases
MANCPEPA_01711 0.0 rnjB - - S ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MANCPEPA_01712 1.57e-201 dapA 4.3.3.7 - E ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MANCPEPA_01713 4.9e-283 dapG 2.7.2.4 - E ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the aspartokinase family
MANCPEPA_01714 1.66e-247 asd 1.2.1.11 - E ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MANCPEPA_01715 9.94e-142 spoVFB - - H ko:K06411 - ko00000 Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
MANCPEPA_01716 5.3e-208 dpaA - - CH ko:K06410 - ko00000 Dipicolinate synthase subunit A
MANCPEPA_01717 1.53e-56 ymxH - - S - - - YlmC YmxH family
MANCPEPA_01718 1.62e-295 mlpA - - S - - - Belongs to the peptidase M16 family
MANCPEPA_01719 9.38e-229 ylxY - - G - - - Sporulation protein, polysaccharide deacetylase
MANCPEPA_01720 0.0 pnp 2.7.7.8 - J ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MANCPEPA_01721 7.11e-57 rpsO - - J ko:K02956 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MANCPEPA_01722 3.84e-231 ribF 2.7.1.26, 2.7.7.2 - H ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Belongs to the ribF family
MANCPEPA_01723 6.04e-220 truB 5.4.99.25 - J ko:K03177,ko:K03483 - ko00000,ko01000,ko03000,ko03016 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MANCPEPA_01724 3.29e-75 rbfA - - J ko:K02834 - ko00000,ko03009 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MANCPEPA_01725 1.11e-59 ylxP - - S ko:K09764 - ko00000 protein conserved in bacteria
MANCPEPA_01726 0.0 infB - - J ko:K02519 - ko00000,ko03012,ko03029 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MANCPEPA_01727 6.16e-63 ylxQ - - J - - - ribosomal protein
MANCPEPA_01728 2.01e-57 ylxR - - K ko:K07742 - ko00000 nucleic-acid-binding protein implicated in transcription termination
MANCPEPA_01729 5.49e-261 nusA - - K ko:K02600 - ko00000,ko03009,ko03021 Participates in both transcription termination and antitermination
MANCPEPA_01730 1.34e-104 rimP - - S ko:K09748 - ko00000,ko03009 Required for maturation of 30S ribosomal subunits
MANCPEPA_01731 0.0 polC 2.7.7.7 - L ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MANCPEPA_01732 0.0 proS 6.1.1.15 - J ko:K01881 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MANCPEPA_01733 6.84e-294 rasP - - M ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 zinc metalloprotease
MANCPEPA_01734 1.39e-276 dxr 1.1.1.267 - I ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MANCPEPA_01735 1.36e-177 cdsA 2.7.7.41 - S ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 ko00000,ko00001,ko00002,ko01000 Belongs to the CDS family
MANCPEPA_01736 3.84e-187 uppS 2.5.1.31 - I ko:K00806 ko00900,ko01110,map00900,map01110 ko00000,ko00001,ko01000,ko01006 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MANCPEPA_01737 9.6e-119 frr - - J ko:K02838 - ko00000,ko03012 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MANCPEPA_01738 5.82e-163 pyrH 2.7.4.22 - F ko:K09903 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko01000 Catalyzes the reversible phosphorylation of UMP to UDP
MANCPEPA_01739 9.82e-202 tsf - - J ko:K02357 - ko00000,ko03012,ko03029 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MANCPEPA_01740 1.49e-168 rpsB - - J ko:K02967 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the universal ribosomal protein uS2 family
MANCPEPA_01741 1.34e-98 ylxL - - - - - - -
MANCPEPA_01742 6.57e-176 sigD - - K ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_01743 9.58e-112 cheD 3.5.1.44 - NT ko:K03411 ko02030,map02030 ko00000,ko00001,ko01000,ko02035 Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
MANCPEPA_01744 5.06e-144 cheC - - NT ko:K03410 ko02030,map02030 ko00000,ko00001,ko02035 COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
MANCPEPA_01745 1.56e-103 cheW - - NT ko:K03408 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 COG0835 Chemotaxis signal transduction protein
MANCPEPA_01746 0.0 cheA 2.7.13.3 - NT ko:K03407 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 COG0643 Chemotaxis protein histidine kinase and related kinases
MANCPEPA_01747 2.58e-252 cheB 3.1.1.61, 3.5.1.44 - NT ko:K03412 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MANCPEPA_01748 1.09e-200 ylxH - - D ko:K04562 - ko00000,ko02035 Belongs to the ParA family
MANCPEPA_01749 5.65e-256 flhF - - N ko:K02404 - ko00000,ko02035 Flagellar biosynthesis regulator FlhF
MANCPEPA_01750 0.0 flhA - - N ko:K02400 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MANCPEPA_01751 2.74e-244 flhB - - N ko:K02401 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MANCPEPA_01752 1.47e-170 fliR - - N ko:K02421 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Flagellar biosynthetic protein FliR
MANCPEPA_01753 5.23e-50 fliQ - - N ko:K02420 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Role in flagellar biosynthesis
MANCPEPA_01754 1.21e-141 fliP - - N ko:K02419 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Plays a role in the flagellum-specific transport system
MANCPEPA_01755 7.87e-137 fliZ - - N ko:K02418 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Flagellar biosynthesis protein, FliO
MANCPEPA_01756 1.22e-76 cheY - - T ko:K03413 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko00002,ko02022,ko02035 response regulator
MANCPEPA_01757 1.38e-253 fliY - - N ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MANCPEPA_01758 6.61e-231 fliM - - N ko:K02416 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MANCPEPA_01759 5.59e-78 fliL - - N ko:K02415 - ko00000,ko02035 Controls the rotational direction of flagella during chemotaxis
MANCPEPA_01760 1.09e-179 flgG - - N ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Flagellar basal body rod
MANCPEPA_01761 2.81e-96 flgD - - N ko:K02389 ko02040,map02040 ko00000,ko00001,ko02035 Flagellar basal body rod modification protein
MANCPEPA_01762 1.28e-311 fliK - - N ko:K02414 ko02040,map02040 ko00000,ko00001,ko02035 Flagellar hook-length control protein
MANCPEPA_01763 5.08e-84 ylxF - - S - - - MgtE intracellular N domain
MANCPEPA_01764 1.79e-91 fliJ - - N ko:K02413 ko02040,map02040 ko00000,ko00001,ko02035 Flagellar biosynthesis chaperone
MANCPEPA_01765 1.22e-307 fliI 3.6.3.14 - NU ko:K02412 ko02040,map02040 ko00000,ko00001,ko01000,ko02035,ko02044 COG1157 Flagellar biosynthesis type III secretory pathway ATPase
MANCPEPA_01766 1.92e-144 fliH - - NU ko:K02411 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 COG1317 Flagellar biosynthesis type III secretory pathway protein
MANCPEPA_01767 6.08e-230 fliG - - N ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MANCPEPA_01768 0.0 fliF - - N ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 The M ring may be actively involved in energy transduction
MANCPEPA_01769 5.5e-53 fliE - - N ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Flagellar hook-basal body
MANCPEPA_01770 7.54e-99 flgC - - N ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Belongs to the flagella basal body rod proteins family
MANCPEPA_01771 1.62e-83 flgB - - N ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
MANCPEPA_01772 1.95e-175 codY - - K ko:K03706 - ko00000,ko03000 DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MANCPEPA_01773 0.0 hslU - - O ko:K03667 - ko00000,ko03110 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MANCPEPA_01774 3.01e-120 hslV 3.4.25.2 - O ko:K01419 - ko00000,ko01000,ko01002 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MANCPEPA_01775 1.13e-217 xerC - - L ko:K03733,ko:K04763 - ko00000,ko03036 tyrosine recombinase XerC
MANCPEPA_01776 2.22e-313 trmFO 2.1.1.74 - J ko:K04094 - ko00000,ko01000,ko03016,ko03036 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MANCPEPA_01777 0.0 topA 5.99.1.2 - L ko:K03168 - ko00000,ko01000,ko03032,ko03400 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MANCPEPA_01778 3.62e-215 dprA - - LU ko:K04096 - ko00000 Rossmann fold nucleotide-binding protein involved in DNA uptake
MANCPEPA_01779 1.53e-213 sucD 6.2.1.5 - C ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MANCPEPA_01780 9.61e-269 sucC 6.2.1.5 - C ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MANCPEPA_01781 1.7e-59 ylqH - - S ko:K04061 - ko00000,ko02044 homolog of the cytoplasmic domain of flagellar protein FhlB
MANCPEPA_01782 0.0 ylqG - - - - - - -
MANCPEPA_01783 1.37e-173 rnhB 3.1.26.4 - L ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MANCPEPA_01784 4.89e-201 rbgA - - S ko:K14540 - ko00000,ko03009 Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MANCPEPA_01785 8.14e-75 rplS - - J ko:K02884 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MANCPEPA_01786 6.9e-177 trmD 2.1.1.228 - J ko:K00554 - ko00000,ko01000,ko03016 Belongs to the RNA methyltransferase TrmD family
MANCPEPA_01787 1.84e-122 rimM - - J ko:K02860 - ko00000,ko03009 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MANCPEPA_01788 3.41e-80 ylqD - - S - - - YlqD protein
MANCPEPA_01789 1.2e-49 ylqC - - S ko:K06960 - ko00000 Belongs to the UPF0109 family
MANCPEPA_01790 1.13e-58 rpsP - - J ko:K02959 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Belongs to the bacterial ribosomal protein bS16 family
MANCPEPA_01791 9.7e-309 ffh 3.6.5.4 - U ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko01000,ko02044 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MANCPEPA_01792 5.64e-66 ylxM - - S ko:K09787 - ko00000 Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MANCPEPA_01793 1.67e-114 - - - - - - - -
MANCPEPA_01794 3.38e-227 ftsY - - U ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MANCPEPA_01795 0.0 smc - - D ko:K03529 - ko00000,ko03036 Required for chromosome condensation and partitioning
MANCPEPA_01796 2.12e-174 rnc 3.1.26.3 - J ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MANCPEPA_01797 1.15e-43 acpP - - IQ ko:K02078 - ko00000,ko00001 Carrier of the growing fatty acid chain in fatty acid biosynthesis
MANCPEPA_01798 3.5e-167 fabG 1.1.1.100 - IQ ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 reductase
MANCPEPA_01799 1.31e-218 fabD 2.3.1.39 - I ko:K00645,ko:K15327,ko:K15329 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 malonyl CoA-acyl carrier protein transacylase
MANCPEPA_01800 8.33e-230 plsX 2.3.1.15 - I ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MANCPEPA_01801 6.22e-121 fapR - - K - - - Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
MANCPEPA_01802 0.0 recG 3.6.4.12 - L ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MANCPEPA_01803 1.19e-201 sdaAA 4.3.1.17 - E ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko00000,ko00001,ko01000 L-serine dehydratase
MANCPEPA_01804 1.45e-153 sdaAB 4.3.1.17 - E ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko00000,ko00001,ko01000 L-serine dehydratase
MANCPEPA_01805 0.0 yloV - - S ko:K07030 - ko00000 kinase related to dihydroxyacetone kinase
MANCPEPA_01806 3.65e-78 yloU - - S - - - protein conserved in bacteria
MANCPEPA_01807 7.06e-36 rpmB - - J ko:K02902 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL28 family
MANCPEPA_01808 8.13e-157 thiN 2.7.6.2 - H ko:K00949 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000 thiamine pyrophosphokinase
MANCPEPA_01809 4.68e-153 rpe 5.1.3.1 - G ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the ribulose-phosphate 3-epimerase family
MANCPEPA_01810 3.92e-215 rsgA 3.1.3.100 - S ko:K06949 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000,ko03009 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MANCPEPA_01811 0.0 prkC 2.7.11.1 - KLT ko:K08884,ko:K12132 - ko00000,ko01000,ko01001 serine threonine protein kinase
MANCPEPA_01812 3.54e-180 stp 3.1.3.16 - T ko:K20074 - ko00000,ko01000,ko01009 phosphatase
MANCPEPA_01813 5.3e-264 rlmN 2.1.1.192 - J ko:K06941 - ko00000,ko01000,ko03009 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MANCPEPA_01814 0.0 sun 2.1.1.176 - J ko:K03500 - ko00000,ko01000,ko03009 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MANCPEPA_01815 1.67e-221 fmt 2.1.2.9 - J ko:K00604 ko00670,ko00970,map00670,map00970 ko00000,ko00001,ko01000 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MANCPEPA_01816 4.8e-109 def 3.5.1.88 - J ko:K01462 - ko00000,ko01000 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MANCPEPA_01817 0.0 priA - - L ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MANCPEPA_01818 7.28e-286 coaBC 4.1.1.36, 6.3.2.5 - H ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MANCPEPA_01819 6.21e-39 rpoZ 2.7.7.6 - K ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MANCPEPA_01820 5.73e-143 gmk 2.7.4.8 - F ko:K00942 ko00230,ko01100,map00230,map01100 ko00000,ko00001,ko00002,ko01000 Essential for recycling GMP and indirectly, cGMP
MANCPEPA_01821 3.97e-54 ylzA - - S ko:K09777 - ko00000 Belongs to the UPF0296 family
MANCPEPA_01822 1.19e-201 yloC - - S - - - stress-induced protein
MANCPEPA_01823 0.0 yloB 3.6.3.8 - P ko:K01537 - ko00000,ko01000 COG0474 Cation transport ATPase
MANCPEPA_01824 0.0 FbpA - - K - - - RNA-binding protein homologous to eukaryotic snRNP
MANCPEPA_01825 6.53e-108 sirC 1.3.1.76, 4.99.1.4 - H ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Siroheme synthase
MANCPEPA_01826 1.45e-187 sirB 4.99.1.4 - S ko:K03794 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Sirohydrochlorin ferrochelatase
MANCPEPA_01827 5.9e-185 cobA 2.1.1.107 - H ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the precorrin methyltransferase family
MANCPEPA_01828 3.76e-140 cysC 2.7.1.25 - P ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the synthesis of activated sulfate
MANCPEPA_01829 2.15e-284 sat 2.7.7.4 - P ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the sulfate adenylyltransferase family
MANCPEPA_01830 6.01e-229 cysP - - P ko:K16331 - ko00000,ko02000 phosphate transporter
MANCPEPA_01831 5.95e-182 cysH 1.8.4.10, 1.8.4.8 - EH ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the PAPS reductase family. CysH subfamily
MANCPEPA_01833 8.96e-149 pyrE 2.4.2.10 - F ko:K00762 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MANCPEPA_01834 8.94e-162 pyrF 4.1.1.23 - F ko:K01591 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MANCPEPA_01835 6.05e-221 pyrD 1.3.1.14 - F ko:K17828 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MANCPEPA_01836 3.69e-183 pyrK - - C ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
MANCPEPA_01837 0.0 carB 6.3.5.5 - F ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the CarB family
MANCPEPA_01838 1.31e-269 carA 6.3.5.5 - F ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Carbamoyl-phosphate synthetase glutamine chain
MANCPEPA_01839 0.0 pyrC 3.5.2.3 - F ko:K01465 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MANCPEPA_01840 7.29e-214 pyrB 2.1.3.2 - F ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the ATCase OTCase family
MANCPEPA_01841 5.27e-294 pyrP - - F ko:K02824 - ko00000,ko02000 Xanthine uracil
MANCPEPA_01842 4.45e-122 pyrR 2.4.2.9 - F ko:K02825 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko01000,ko03000 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MANCPEPA_01843 1.01e-224 rluD 5.4.99.23 - J ko:K06180 - ko00000,ko01000,ko03009 Responsible for synthesis of pseudouridine from uracil
MANCPEPA_01844 2.71e-103 lspA 3.4.23.36 - MU ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MANCPEPA_01845 1.58e-83 ylyA - - T - - - COG1734 DnaK suppressor protein
MANCPEPA_01846 0.0 ileS 6.1.1.5 - J ko:K01870 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MANCPEPA_01847 6.44e-100 divIVA - - D ko:K04074 - ko00000,ko03036 Cell division initiation protein
MANCPEPA_01848 1.49e-178 ylmH - - S - - - conserved protein, contains S4-like domain
MANCPEPA_01849 1.22e-53 ylmG - - S ko:K02221 - ko00000,ko02044 membrane
MANCPEPA_01850 5.44e-88 sepF - - D ko:K09772 - ko00000,ko03036 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MANCPEPA_01851 1.05e-160 ylmE - - S ko:K06997 - ko00000 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MANCPEPA_01852 1.78e-201 ylmD - - S ko:K05810 - ko00000,ko01000 Belongs to the multicopper oxidase YfiH RL5 family
MANCPEPA_01853 3.58e-51 ylmC - - S - - - sporulation protein
MANCPEPA_01854 8.98e-315 argE - - E ko:K20895 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000 Acetylornithine deacetylase
MANCPEPA_01855 1.57e-188 ylmA 3.6.3.34 - P ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
MANCPEPA_01856 7.99e-180 sigG - - K ko:K03091 - ko00000,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_01857 1.48e-160 sigE - - K ko:K03091 - ko00000,ko03021 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_01858 6.04e-220 spoIIGA - - M ko:K06383 - ko00000,ko01000,ko01002 aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
MANCPEPA_01859 0.0 bpr - - O ko:K13276 - ko00000,ko01000,ko01002,ko03110 COG1404 Subtilisin-like serine proteases
MANCPEPA_01860 1.84e-260 ftsZ - - D ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MANCPEPA_01861 4.88e-299 ftsA - - D ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MANCPEPA_01862 5.37e-76 sbp - - S - - - small basic protein
MANCPEPA_01863 1.03e-123 ylxX - - S - - - protein conserved in bacteria
MANCPEPA_01864 4.5e-142 ylxW - - S - - - protein conserved in bacteria
MANCPEPA_01865 1.18e-178 divIB - - D ko:K03589 ko04112,map04112 ko00000,ko00001,ko03036 Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MANCPEPA_01866 3.74e-211 murB 1.3.1.98 - M ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 ko00000,ko00001,ko01000,ko01011 cell wall formation
MANCPEPA_01867 7.74e-257 murG 2.4.1.227 GT28 M ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 ko00000,ko00001,ko01000,ko01011 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MANCPEPA_01868 6.64e-237 spoVE - - D ko:K03588 ko04112,map04112 ko00000,ko00001,ko02000,ko03036 Belongs to the SEDS family
MANCPEPA_01869 0.0 murD 6.3.2.9 - M ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 ko00000,ko00001,ko01000,ko01011 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MANCPEPA_01870 9.59e-220 mraY 2.7.8.13 - M ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 ko00000,ko00001,ko01000,ko01011 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MANCPEPA_01871 0.0 murE 6.3.2.13 - M ko:K01928 ko00300,ko00550,map00300,map00550 ko00000,ko00001,ko01000,ko01011 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MANCPEPA_01872 0.0 spoVD - - M ko:K08384 ko00550,map00550 ko00000,ko00001,ko01011 stage V sporulation protein D
MANCPEPA_01873 0.0 pbpX - - M ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011 Penicillin-binding Protein
MANCPEPA_01874 3.42e-68 ftsL - - D - - - Essential cell division protein
MANCPEPA_01875 4.76e-218 rsmH 2.1.1.199 - J ko:K03438 - ko00000,ko01000,ko03009 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MANCPEPA_01876 9.82e-102 mraZ - - K ko:K03925 - ko00000 Belongs to the MraZ family
MANCPEPA_01877 0.0 bshC - - S ko:K22136 - ko00000 Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MANCPEPA_01878 3.22e-214 panE 1.1.1.169 - H ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MANCPEPA_01879 1.33e-115 ylbP - - K - - - n-acetyltransferase
MANCPEPA_01880 1.35e-106 ylbO - - S ko:K06314 - ko00000,ko03000 SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
MANCPEPA_01881 1.71e-37 rpmF - - J ko:K02911 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Belongs to the bacterial ribosomal protein bL32 family
MANCPEPA_01882 6.94e-117 ylbN - - S ko:K07040 - ko00000 metal-binding, possibly nucleic acid-binding protein
MANCPEPA_01884 5.94e-301 ylbM - - S - - - Belongs to the UPF0348 family
MANCPEPA_01885 1.58e-238 ylbL - - T ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Belongs to the peptidase S16 family
MANCPEPA_01886 3.64e-176 ylbK - - S ko:K07001 - ko00000 esterase of the alpha-beta hydrolase superfamily
MANCPEPA_01887 3.87e-282 ylbJ - - S - - - Sporulation integral membrane protein YlbJ
MANCPEPA_01888 3.8e-111 coaD 2.7.7.3 - H ko:K00954 ko00770,ko01100,map00770,map01100 ko00000,ko00001,ko00002,ko01000 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MANCPEPA_01889 3.51e-125 rsmD 2.1.1.171 - L ko:K08316 - ko00000,ko01000,ko03009 Methyltransferase
MANCPEPA_01890 5.1e-51 ylbG - - S - - - UPF0298 protein
MANCPEPA_01891 2.34e-97 ylbF - - S - - - Belongs to the UPF0342 family
MANCPEPA_01892 1.73e-48 ylbE - - S - - - YlbE-like protein
MANCPEPA_01893 3.24e-89 ylbD - - S - - - Putative coat protein
MANCPEPA_01894 1.53e-256 ylbC - - S - - - protein with SCP PR1 domains
MANCPEPA_01895 1.08e-97 ylbB - - T - - - COG0517 FOG CBS domain
MANCPEPA_01896 1.61e-81 ylbA - - S - - - YugN-like family
MANCPEPA_01897 1.48e-214 ctaG - - S ko:K02862 - ko00000 cytochrome c oxidase
MANCPEPA_01898 6.09e-70 ctaF 1.9.3.1 - C ko:K02277 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
MANCPEPA_01899 6.17e-144 ctaE 1.9.3.1 - C ko:K02276 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
MANCPEPA_01900 0.0 ctaD 1.9.3.1 - C ko:K02274 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MANCPEPA_01901 2.38e-252 ctaC 1.9.3.1 - C ko:K02275 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MANCPEPA_01902 1.7e-208 ctaB 2.5.1.141 - O ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MANCPEPA_01903 2e-212 ctaA - - O ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 ko00000,ko00001,ko00002,ko03029 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
MANCPEPA_01904 0.0 pyc 6.4.1.1 - C ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MANCPEPA_01905 8.59e-272 ftsW - - D ko:K03588 ko04112,map04112 ko00000,ko00001,ko02000,ko03036 Belongs to the SEDS family
MANCPEPA_01906 6.94e-59 ylaN - - S - - - Belongs to the UPF0358 family
MANCPEPA_01907 3.49e-219 glsA 3.5.1.2 - E ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 ko00000,ko00001,ko01000 Belongs to the glutaminase family
MANCPEPA_01908 9.32e-112 ylaL - - S - - - Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MANCPEPA_01909 3.76e-316 ylaK - - T ko:K07175 - ko00000 ATPase related to phosphate starvation-inducible protein PhoH
MANCPEPA_01910 2.97e-127 ylaJ - - S - - - Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MANCPEPA_01911 8.92e-44 ylaI - - S - - - protein conserved in bacteria
MANCPEPA_01912 4.4e-63 ylaH - - S - - - YlaH-like protein
MANCPEPA_01913 0.0 typA - - T ko:K06207 - ko00000 GTP-binding protein TypA
MANCPEPA_01914 1.56e-30 - - - S - - - Family of unknown function (DUF5325)
MANCPEPA_01915 1.31e-54 ylaE - - - - - - -
MANCPEPA_01917 3.56e-115 ylaC - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_01918 2.79e-54 ylaB - - - - - - -
MANCPEPA_01919 0.0 ylaA - - - - - - -
MANCPEPA_01920 0.0 mpl 3.4.24.28, 3.4.24.29 - E ko:K01400,ko:K01401,ko:K19351 ko01503,ko05150,map01503,map05150 ko00000,ko00001,ko01000,ko01002 Peptidase M4
MANCPEPA_01921 5.82e-220 - - - Q - - - Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MANCPEPA_01922 2.45e-99 ykzC - - S - - - Acetyltransferase (GNAT) family
MANCPEPA_01923 7.8e-194 suhB 3.1.3.25 - G ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 ko00000,ko00001,ko00002,ko01000 Inositol monophosphatase
MANCPEPA_01924 4.48e-35 ykzI - - - - - - -
MANCPEPA_01925 5.28e-152 yktB - - S - - - Belongs to the UPF0637 family
MANCPEPA_01926 1.34e-56 yktA - - S - - - Belongs to the UPF0223 family
MANCPEPA_01927 0.0 speA 4.1.1.17, 4.1.1.19 - E ko:K01581,ko:K01585 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Arginine
MANCPEPA_01928 4.55e-83 slp - - CO - - - COG0526, thiol-disulfide isomerase and thioredoxins
MANCPEPA_01929 0.0 pdhD 1.8.1.4 - C ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MANCPEPA_01930 1.47e-301 pdhC 2.3.1.12 - C ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MANCPEPA_01931 1.75e-227 pdhB 1.2.4.1 - C ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 br01601,ko00000,ko00001,ko00002,ko01000 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MANCPEPA_01932 1.06e-258 pdhA 1.2.4.1 - C ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 br01601,ko00000,ko00001,ko00002,ko01000 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MANCPEPA_01933 2.22e-140 ykyA - - L - - - Putative cell-wall binding lipoprotein
MANCPEPA_01934 2.24e-19 - - - S - - - Protein of unknown function (Tiny_TM_bacill)
MANCPEPA_01935 3.96e-131 def 3.5.1.88 - J ko:K01462 - ko00000,ko01000 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MANCPEPA_01936 4.79e-186 ykrA - - S - - - hydrolases of the HAD superfamily
MANCPEPA_01937 8.98e-42 ykzG - - S - - - Belongs to the UPF0356 family
MANCPEPA_01938 0.0 rnjA - - S ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MANCPEPA_01939 0.0 ade 3.5.4.2 - F ko:K01486 ko00230,ko01100,map00230,map01100 ko00000,ko00001,ko01000 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MANCPEPA_01940 1.68e-148 ktrA - - P ko:K03499 - ko00000,ko02000 COG0569 K transport systems, NAD-binding component
MANCPEPA_01941 8.76e-201 ykqA - - P - - - Gamma-glutamyl cyclotransferase, AIG2-like
MANCPEPA_01942 4.59e-307 kinC 2.7.13.3 - T ko:K07698 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 COG0642 Signal transduction histidine kinase
MANCPEPA_01943 2.63e-58 abrB - - K ko:K06284 - ko00000,ko03000 of stationary sporulation gene expression
MANCPEPA_01944 6.17e-234 mreBH - - D ko:K03569 - ko00000,ko02048,ko03036,ko04812 Rod-share determining protein MreBH
MANCPEPA_01945 1.09e-18 - - - S - - - Uncharacterized protein YkpC
MANCPEPA_01946 5.94e-303 pepS - - E ko:K19689 - ko00000,ko01000,ko01002 COG2309 Leucyl aminopeptidase (aminopeptidase T)
MANCPEPA_01947 2.86e-215 panE1 1.1.1.169 - H ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MANCPEPA_01948 0.0 ykpA - - S - - - COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MANCPEPA_01949 5.43e-52 ykoA - - - - - - -
MANCPEPA_01950 1.72e-134 sipT 3.4.21.89 - U ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Belongs to the peptidase S26 family
MANCPEPA_01951 0.0 fruA 2.7.1.202 - GT ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
MANCPEPA_01952 9.99e-216 pfkB 2.7.1.56 - G ko:K00882 ko00051,map00051 ko00000,ko00001,ko01000 Belongs to the carbohydrate kinase PfkB family
MANCPEPA_01953 1.49e-175 fruR - - K ko:K03436 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01954 2.1e-269 yknZ - - V ko:K02004 - ko00000,ko00002,ko02000 COG0577 ABC-type antimicrobial peptide transport system, permease component
MANCPEPA_01955 6.1e-160 yknY - - V ko:K02003 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_01956 4.93e-235 yknX - - M ko:K02005,ko:K13888 - ko00000,ko00002,ko02000 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MANCPEPA_01957 1.6e-151 yknW - - S - - - Yip1 domain
MANCPEPA_01958 0.0 yknV - - V ko:K02021,ko:K06147,ko:K18890 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1132 ABC-type multidrug transport system, ATPase and permease components
MANCPEPA_01959 0.0 yknU - - V ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 COG1132 ABC-type multidrug transport system, ATPase and permease components
MANCPEPA_01960 2.82e-44 moaD - - H ko:K03636 ko04122,map04122 ko00000,ko00001 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MANCPEPA_01961 3.83e-109 moaE 2.8.1.12 - H ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 ko00000,ko00001,ko01000 COG0314 Molybdopterin converting factor, large subunit
MANCPEPA_01962 4.89e-122 mobB - - H ko:K03753 - ko00000 molybdopterin-guanine dinucleotide biosynthesis protein
MANCPEPA_01963 2.38e-310 moeA 2.10.1.1 - H ko:K03750 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000 molybdopterin
MANCPEPA_01964 1.26e-243 moeB 2.7.7.73, 2.7.7.80 - H ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MANCPEPA_01965 3.75e-141 mobA 2.7.7.77 - H ko:K03752 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MANCPEPA_01966 2.43e-200 yknT - - - ko:K06437 - ko00000 -
MANCPEPA_01967 4.71e-122 rok - - K - - - Repressor of ComK
MANCPEPA_01968 1.47e-104 ykuV - - CO - - - thiol-disulfide
MANCPEPA_01969 9.78e-130 ykuU - - O - - - Alkyl hydroperoxide reductase
MANCPEPA_01970 4.1e-181 ykuT - - M ko:K22044 - ko00000,ko02000 Mechanosensitive ion channel
MANCPEPA_01971 7.23e-51 ykuS - - S - - - Belongs to the UPF0180 family
MANCPEPA_01972 7.99e-276 hipO 3.5.1.47 - E ko:K05823 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000,ko01002 Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MANCPEPA_01973 1.31e-125 dapH 2.3.1.117, 2.3.1.89 - E ko:K00674,ko:K05822 ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MANCPEPA_01974 1.3e-104 fld - - C ko:K03839 - ko00000 Flavodoxin
MANCPEPA_01975 1.33e-226 ykuO - - - - - - -
MANCPEPA_01976 6.35e-113 - - - C ko:K03839 - ko00000 Flavodoxin domain
MANCPEPA_01977 6.52e-216 ccpC - - K - - - Transcriptional regulator
MANCPEPA_01978 5.15e-100 ykuL - - S - - - CBS domain
MANCPEPA_01979 7.83e-38 ykzF - - S - - - Antirepressor AbbA
MANCPEPA_01980 6.44e-122 - - - S ko:K09776 - ko00000 Ribonuclease H-like
MANCPEPA_01981 5.16e-50 ykuJ - - S - - - protein conserved in bacteria
MANCPEPA_01982 1.76e-298 ykuI - - T - - - Diguanylate phosphodiesterase
MANCPEPA_01983 1.83e-182 fadH 1.3.1.34 - IQ ko:K00219 - ko00000,ko01000 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_01984 3.48e-212 ykuE - - S ko:K07098 - ko00000 Metallophosphoesterase
MANCPEPA_01985 5.84e-115 ykuD - - S - - - protein conserved in bacteria
MANCPEPA_01986 3.62e-305 ykuC - - EGP - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_01987 3.71e-110 ykyB - - S - - - YkyB-like protein
MANCPEPA_01988 4.24e-217 cheV - - T ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko00002,ko02022,ko02035 Chemotaxis protein CheV
MANCPEPA_01989 1.05e-22 - - - - - - - -
MANCPEPA_01990 1.78e-284 patA - - E ko:K00841 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 Aminotransferase
MANCPEPA_01991 0.0 kinA 2.7.13.3 - T ko:K02491 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_01992 0.0 pbp2b - - M ko:K00687,ko:K12553,ko:K21465,ko:K21466 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011 Penicillin-binding Protein
MANCPEPA_01993 2.97e-169 ykwD - - J - - - protein with SCP PR1 domains
MANCPEPA_01994 4.02e-203 glxR 1.1.1.31 - I ko:K00020 ko00280,ko01100,map00280,map01100 ko00000,ko00001,ko01000 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
MANCPEPA_01995 0.0 mcpC - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_01996 1.06e-167 ykwB - - K - - - COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_01997 2.49e-256 splB 4.1.99.14 - L ko:K03716 - ko00000,ko01000 Spore photoproduct lyase
MANCPEPA_01998 1.54e-51 splA - - S ko:K06315 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_01999 0.0 ptsI 2.7.3.9 - G ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANCPEPA_02000 1.51e-53 ptsH - - G ko:K11189 - ko00000,ko02000 phosphocarrier protein HPr
MANCPEPA_02001 0.0 ptsG 2.7.1.199 - G ko:K02763,ko:K02764,ko:K02765,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_02002 6.87e-168 glcT - - K ko:K03480,ko:K03488 - ko00000,ko03000 antiterminator
MANCPEPA_02004 5.43e-229 ykvZ - - K - - - Transcriptional regulator
MANCPEPA_02005 1.93e-264 ykvY 3.4.13.9 - E ko:K01271 - ko00000,ko01000,ko01002 COG0006 Xaa-Pro aminopeptidase
MANCPEPA_02006 3.99e-09 - - - - - - - -
MANCPEPA_02007 0.0 zosA 3.6.3.3, 3.6.3.5 - P ko:K01534 - ko00000,ko01000 COG2217 Cation transport ATPase
MANCPEPA_02008 5.57e-115 stoA - - CO - - - thiol-disulfide
MANCPEPA_02009 6.46e-302 ykvU - - S - - - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_02010 3.04e-140 ykvT 3.5.1.28 - M ko:K01449 - ko00000,ko01000 Cell Wall Hydrolase
MANCPEPA_02011 2.6e-39 - - - - - - - -
MANCPEPA_02012 5.43e-35 ykvS - - S - - - protein conserved in bacteria
MANCPEPA_02013 2.57e-60 ykvR - - S - - - Protein of unknown function (DUF3219)
MANCPEPA_02014 2.9e-203 - - - G - - - Glycosyl hydrolases family 18
MANCPEPA_02015 2.17e-47 - 3.5.1.104 - M ko:K22278 - ko00000,ko01000 LysM domain
MANCPEPA_02016 1.74e-271 - - - M - - - Glycosyl transferases group 1
MANCPEPA_02017 1.09e-171 ykvO - - IQ - - - Enoyl-(Acyl carrier protein) reductase
MANCPEPA_02018 3.53e-81 ykvN - - K - - - Transcriptional regulator
MANCPEPA_02019 2.36e-125 queF 1.7.1.13 - S ko:K09457 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000,ko03016 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MANCPEPA_02020 3.56e-179 queE 4.3.99.3 - H ko:K10026 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000,ko03016 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MANCPEPA_02021 6.96e-105 queD 4.1.2.50, 4.2.3.12 - H ko:K01737 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000,ko03016 synthase
MANCPEPA_02022 2.61e-160 queC 6.3.4.20 - F ko:K06920 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko01000,ko03016 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MANCPEPA_02023 6.76e-227 ykvI - - S - - - membrane
MANCPEPA_02024 0.0 clpE - - O ko:K03697,ko:K04086 - ko00000,ko03110 Belongs to the ClpA ClpB family
MANCPEPA_02025 1.65e-177 motA - - N ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 flagellar motor
MANCPEPA_02026 4.91e-170 motB - - N ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 Flagellar motor protein
MANCPEPA_02027 5.17e-99 ykvE - - K ko:K15973 - ko00000,ko03000 transcriptional
MANCPEPA_02028 0.0 kinD 2.7.13.3 - T ko:K13532 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 COG0642 Signal transduction histidine kinase
MANCPEPA_02029 5.62e-93 eag - - - - - - -
MANCPEPA_02031 8.82e-68 - - - S - - - Protein of unknown function (DUF1232)
MANCPEPA_02032 8.7e-123 mtnD 1.13.11.53, 1.13.11.54 - S ko:K08967 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MANCPEPA_02033 3.71e-146 mtnB 4.2.1.109 - E ko:K08964 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
MANCPEPA_02034 2.06e-174 mtnX 3.1.3.87 - E ko:K08966 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MANCPEPA_02035 5.62e-294 mtnW 5.3.2.5 - G ko:K08965 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
MANCPEPA_02036 6.56e-294 mtnE - - E ko:K08969,ko:K19549 ko00270,ko01100,ko01130,map00270,map01100,map01130 ko00000,ko00001,ko00002,ko01000,ko01007 Aminotransferase
MANCPEPA_02037 1.64e-192 mtnU 3.5.1.3 - S ko:K13566 ko00250,map00250 ko00000,ko00001,ko01000 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MANCPEPA_02038 9.63e-291 mtnK 2.7.1.100 - F ko:K00899 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MANCPEPA_02039 4.44e-251 mtnA 5.3.1.23 - E ko:K08963 ko00270,ko01100,map00270,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MANCPEPA_02041 1.6e-114 ogt 2.1.1.63 - L ko:K00567,ko:K13531 - ko00000,ko01000,ko03400 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MANCPEPA_02042 0.0 kinE 2.7.13.3 - T ko:K13533 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_02043 3.34e-244 ykrP - - G - - - COG3594 Fucose 4-O-acetylase and related acetyltransferases
MANCPEPA_02044 1.77e-28 ykzE - - - - - - -
MANCPEPA_02046 1.82e-310 ktrD - - P - - - COG0168 Trk-type K transport systems, membrane components
MANCPEPA_02047 9.33e-198 htpX - - O ko:K03799 - ko00000,ko00002,ko01000,ko01002 Belongs to the peptidase M48B family
MANCPEPA_02048 7.68e-160 ykrK - - S - - - Domain of unknown function (DUF1836)
MANCPEPA_02049 1.4e-36 sspD - - S ko:K06421 - ko00000 small acid-soluble spore protein
MANCPEPA_02050 1.63e-212 rsgI - - S - - - Anti-sigma factor N-terminus
MANCPEPA_02051 1.8e-167 sigI - - K ko:K03093 - ko00000,ko03021 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANCPEPA_02052 1.33e-226 ykoY - - P - - - COG0861 Membrane protein TerC, possibly involved in tellurium resistance
MANCPEPA_02053 1.71e-143 ykoX - - S - - - membrane-associated protein
MANCPEPA_02054 0.0 ykoW 2.7.7.65 - T ko:K21023 ko02025,map02025 ko00000,ko00001,ko01000 Diguanylate cyclase
MANCPEPA_02055 5.1e-204 ku - - L ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MANCPEPA_02056 0.0 ligD 6.5.1.1 - L ko:K01971 ko03450,map03450 ko00000,ko00001,ko01000,ko03400 ATP-dependent DNA ligase
MANCPEPA_02057 9.49e-238 ykoT - - M - - - COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_02058 0.0 ykoS - - - - - - -
MANCPEPA_02059 1.77e-197 ykoQ - - S ko:K07098 - ko00000 Calcineurin-like phosphoesterase superfamily domain
MANCPEPA_02060 2.48e-129 ykoP - - G - - - polysaccharide deacetylase
MANCPEPA_02061 2.21e-277 ugtP 2.4.1.315 GT28 M ko:K03429 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko01000,ko01003 COG0707 UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase
MANCPEPA_02062 9.83e-106 ykoM - - K ko:K15973 - ko00000,ko03000 transcriptional
MANCPEPA_02063 3.04e-36 ykoL - - - - - - -
MANCPEPA_02064 1.63e-25 - - - - - - - -
MANCPEPA_02065 1.49e-70 tnrA - - K - - - transcriptional
MANCPEPA_02066 9.86e-300 mgtE - - P ko:K06213 - ko00000,ko02000 Acts as a magnesium transporter
MANCPEPA_02068 1.45e-08 - - - - - - - -
MANCPEPA_02069 1.3e-111 ykoJ - - S - - - Peptidase propeptide and YPEB domain
MANCPEPA_02070 5.55e-145 ykoI - - S - - - Peptidase propeptide and YPEB domain
MANCPEPA_02071 8.59e-307 ykoH - - T - - - Histidine kinase
MANCPEPA_02072 5.02e-158 ykoG - - T ko:K02483 - ko00000,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_02073 3.07e-138 ykoF - - S - - - YKOF-related Family
MANCPEPA_02074 8.05e-127 ykoE - - S ko:K16925 - ko00000,ko00002,ko02000 ABC-type cobalt transport system, permease component
MANCPEPA_02075 0.0 ykoD - - P ko:K16786,ko:K16787 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02076 1.22e-171 ykoC - - P ko:K16785 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Cobalt transport protein
MANCPEPA_02077 3.27e-192 - - - T ko:K17763 - ko00000,ko03021 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MANCPEPA_02078 4.27e-225 isp - - O ko:K13275 - ko00000,ko01000,ko01002,ko03110 Belongs to the peptidase S8 family
MANCPEPA_02079 0.0 metE 2.1.1.14 - E ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MANCPEPA_02080 5.67e-115 guaD 3.5.4.3 - FJ ko:K01487 ko00230,ko01100,map00230,map01100 ko00000,ko00001,ko01000 COG0590 Cytosine adenosine deaminases
MANCPEPA_02081 1.65e-93 ohrB - - O - - - Organic hydroperoxide resistance protein
MANCPEPA_02082 1.42e-97 ohrR - - K - - - COG1846 Transcriptional regulators
MANCPEPA_02083 2.39e-93 ohrA - - O - - - Organic hydroperoxide resistance protein
MANCPEPA_02084 1.32e-288 proA 1.2.1.41 - E ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MANCPEPA_02085 6.1e-255 proB 2.7.2.11 - E ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MANCPEPA_02086 5.81e-218 purU 3.5.1.10 - F ko:K01433 ko00630,ko00670,map00630,map00670 ko00000,ko00001,ko01000 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
MANCPEPA_02087 1.36e-66 ykkD - - P ko:K18925 - ko00000,ko00002,ko02000 Multidrug resistance protein
MANCPEPA_02088 1.27e-72 ykkC - - P ko:K18924 - ko00000,ko00002,ko02000 Multidrug resistance protein
MANCPEPA_02089 1.71e-126 ykkB - - J - - - COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MANCPEPA_02090 6.42e-128 ykkA - - S - - - Protein of unknown function (DUF664)
MANCPEPA_02091 3.95e-167 ykjA - - S - - - Protein of unknown function (DUF421)
MANCPEPA_02092 2.73e-284 hmp 1.14.12.17, 1.18.1.3 - C ko:K05916,ko:K15765 ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132 ko00000,ko00001,ko00002,ko01000 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MANCPEPA_02093 1.55e-119 ykhA - - I - - - Acyl-CoA hydrolase
MANCPEPA_02094 1.78e-205 ykgA - - E - - - Amidinotransferase
MANCPEPA_02095 3.29e-260 pgl 3.1.1.31 - G ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 6-phosphogluconolactonase
MANCPEPA_02096 3.58e-238 ykfD - - E ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02097 2.17e-211 ykfC 3.4.14.13 - M ko:K20742 - ko00000,ko01000,ko01002 COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MANCPEPA_02098 1.62e-255 ykfB 5.1.1.20 - M ko:K19802 - ko00000,ko01000 Belongs to the mandelate racemase muconate lactonizing enzyme family
MANCPEPA_02099 6.49e-223 ykfA 3.4.17.13 - V ko:K01297 - ko00000,ko01000,ko01002,ko01011 proteins, homologs of microcin C7 resistance protein MccF
MANCPEPA_02101 0.0 dppE - - E ko:K16199 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter substrate-binding protein
MANCPEPA_02102 1.35e-236 dppD - - P ko:K02031,ko:K15583,ko:K16202 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02103 3.02e-224 dppC - - EP ko:K15582,ko:K16201 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02104 9.7e-204 dppB - - P ko:K16200 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02105 1.4e-196 dppA - - E ko:K16203 - ko00000,ko01000,ko01002 D-aminopeptidase
MANCPEPA_02106 2.25e-176 proG 1.5.1.2 - E ko:K00286,ko:K02239 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000,ko02044 Pyrroline-5-carboxylate reductase
MANCPEPA_02107 2.4e-282 htrA 3.4.21.107 - O ko:K04771 ko01503,ko02020,map01503,map02020 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANCPEPA_02109 2.21e-229 ykcC - GT2 M ko:K20534 - ko00000,ko01000,ko01005,ko02000 COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_02110 0.0 ykcB - - M - - - COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MANCPEPA_02111 2.31e-232 ykcA - - E ko:K15975 - ko00000 COG0346 Lactoylglutathione lyase and related lyases
MANCPEPA_02112 2.57e-309 steT - - E ko:K03294 - ko00000 amino acid
MANCPEPA_02113 1.85e-144 ykaA - - P ko:K07220 - ko00000 COG1392 Phosphate transport regulator (distant homolog of PhoU)
MANCPEPA_02114 1.54e-225 pit - - P ko:K03306 - ko00000 phosphate transporter
MANCPEPA_02115 1.19e-175 spoIISA - - S ko:K06388 - ko00000 Toxin SpoIISA, type II toxin-antitoxin system
MANCPEPA_02116 1.78e-31 spoIISB - - S ko:K06389 - ko00000 Stage II sporulation protein SB
MANCPEPA_02117 2.07e-205 xlyA 3.5.1.28 - M ko:K01447 - ko00000,ko01000 n-acetylmuramoyl-L-alanine amidase
MANCPEPA_02118 1.15e-52 xhlB - - S - - - SPP1 phage holin
MANCPEPA_02119 2.21e-51 xhlA - - S - - - Haemolysin XhlA
MANCPEPA_02120 1.39e-194 xepA - - - - - - -
MANCPEPA_02121 2.68e-32 xkdX - - - - - - -
MANCPEPA_02122 8.68e-74 xkdW - - S - - - XkdW protein
MANCPEPA_02123 0.0 - - - - - - - -
MANCPEPA_02124 6.29e-56 - - - - - - - -
MANCPEPA_02125 3.23e-134 - - - S - - - Uncharacterised protein conserved in bacteria (DUF2313)
MANCPEPA_02126 1.79e-243 - - - S - - - Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MANCPEPA_02127 7.71e-90 xkdS - - S - - - Protein of unknown function (DUF2634)
MANCPEPA_02128 1.76e-52 xkdR - - S - - - Protein of unknown function (DUF2577)
MANCPEPA_02129 2.31e-232 xkdQ - - G - - - NLP P60 protein
MANCPEPA_02130 1.77e-158 xkdP - - S - - - Lysin motif
MANCPEPA_02131 0.0 xkdO - - L - - - Transglycosylase SLT domain
MANCPEPA_02132 3.34e-101 - - - S - - - Phage XkdN-like tail assembly chaperone protein, TAC
MANCPEPA_02133 6.01e-99 xkdM - - S - - - Phage tail tube protein
MANCPEPA_02134 0.0 xkdK - - S - - - Phage tail sheath C-terminal domain
MANCPEPA_02135 2.87e-101 xkdJ - - - - - - -
MANCPEPA_02136 2.78e-113 xkdI - - S - - - Bacteriophage HK97-gp10, putative tail-component
MANCPEPA_02137 1.75e-84 yqbH - - S - - - Domain of unknown function (DUF3599)
MANCPEPA_02138 4.68e-82 yqbG - - S - - - Protein of unknown function (DUF3199)
MANCPEPA_02139 3.91e-217 xkdG - - S - - - Phage capsid family
MANCPEPA_02140 1.99e-176 xkdF3 - - L - - - Putative phage serine protease XkdF
MANCPEPA_02141 0.0 yqbA - - S - - - portal protein
MANCPEPA_02142 0.0 xtmB - - S ko:K06909 - ko00000 phage terminase, large subunit
MANCPEPA_02143 7.93e-178 xtmA - - L ko:K07474 - ko00000 phage terminase small subunit
MANCPEPA_02144 9.88e-111 xpf - - K ko:K03088 - ko00000,ko03021 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MANCPEPA_02148 1.02e-150 xkdC - - L - - - Bacterial dnaA protein
MANCPEPA_02149 3.07e-202 xkdB - - K - - - sequence-specific DNA binding
MANCPEPA_02151 2.01e-74 xre - - K - - - Helix-turn-helix XRE-family like proteins
MANCPEPA_02152 1.79e-143 xkdA - - E - - - IrrE N-terminal-like domain
MANCPEPA_02153 4.54e-204 yjqC - - P ko:K07217 - ko00000 Catalase
MANCPEPA_02154 5.99e-143 yjqB - - S - - - Pfam:DUF867
MANCPEPA_02155 2.24e-79 yjqA - - S - - - Bacterial PH domain
MANCPEPA_02156 1.37e-220 xlyB 3.5.1.28 - M ko:K01447 - ko00000,ko01000 N-acetylmuramoyl-L-alanine amidase
MANCPEPA_02157 1.79e-55 - - - S - - - YCII-related domain
MANCPEPA_02159 8.59e-272 rapA - - S ko:K06359,ko:K06360,ko:K06367 ko02024,map02024 ko00000,ko00001,ko01000 Response regulator aspartate phosphatase
MANCPEPA_02160 1.18e-311 VCP - - O - - - AAA domain (dynein-related subfamily)
MANCPEPA_02161 2.71e-103 yjoA - - S - - - DinB family
MANCPEPA_02162 4.56e-167 yjnA - - S ko:K07090 - ko00000 membrane transporter protein
MANCPEPA_02163 0.0 uxaA 4.2.1.42, 4.2.1.7 - G ko:K01685,ko:K01708 ko00040,ko00053,ko01100,map00040,map00053,map01100 ko00000,ko00001,ko00002,ko01000 Altronate
MANCPEPA_02164 0.0 uxaB 1.1.1.58 - G ko:K00041 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko00002,ko01000 tagaturonate reductase activity
MANCPEPA_02165 6.95e-238 exuR - - K ko:K02529 - ko00000,ko03000 transcriptional
MANCPEPA_02166 3.76e-287 exuT - - G ko:K03535,ko:K08191 - ko00000,ko02000 Sugar (and other) transporter
MANCPEPA_02167 1.34e-196 yjmF - - IQ - - - Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_02168 1.37e-273 uxuA 4.2.1.8 - G ko:K01686 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the dehydration of D-mannonate
MANCPEPA_02169 9.24e-246 yjmD 1.1.1.380 - E ko:K08322 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko01000 Alcohol dehydrogenase GroES-like domain
MANCPEPA_02170 2.08e-241 allD 1.1.1.350 - C ko:K00073 ko00230,ko01120,map00230,map01120 ko00000,ko00001,ko01000 Belongs to the LDH2 MDH2 oxidoreductase family
MANCPEPA_02171 4.34e-314 - - - G ko:K03292 - ko00000 symporter YjmB
MANCPEPA_02172 0.0 uxaC 5.3.1.12 - G ko:K01812 ko00040,ko01100,map00040,map01100 ko00000,ko00001,ko00002,ko01000 glucuronate isomerase
MANCPEPA_02173 3.56e-279 yjlD 1.6.99.3 - C ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 NADH dehydrogenase
MANCPEPA_02174 1.39e-87 yjlC - - S - - - Protein of unknown function (DUF1641)
MANCPEPA_02175 2.36e-116 yjlB - - S - - - Cupin domain
MANCPEPA_02176 7.35e-224 yjlA - - EG - - - Putative multidrug resistance efflux transporter
MANCPEPA_02177 1.27e-171 yjkB - - P ko:K02068 - ko00000,ko00002,ko02000 ATPases associated with a variety of cellular activities
MANCPEPA_02178 9.04e-156 ybbM - - S ko:K02069 - ko00000,ko00002,ko02000 transport system, permease component
MANCPEPA_02179 1.23e-188 hemD 4.2.1.75 - H ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000 Uroporphyrinogen-III synthase
MANCPEPA_02180 1.11e-41 - - - - - - - -
MANCPEPA_02181 2.8e-276 yjiC - - CG - - - COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MANCPEPA_02182 7.52e-283 yjiB 1.14.14.46, 1.14.15.13 - C ko:K15468,ko:K16593,ko:K17474 ko00780,ko01100,map00780,map01100 ko00000,ko00001,ko00002,ko00199,ko01000,ko01008 Cytochrome P450
MANCPEPA_02184 2.06e-144 yjhB 3.6.1.13 - F ko:K01515 ko00230,map00230 ko00000,ko00001,ko01000 ADP-ribose pyrophosphatase
MANCPEPA_02186 9.24e-122 yjgD - - S - - - Protein of unknown function (DUF1641)
MANCPEPA_02187 0.0 yjgC 1.17.1.9 - C ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko00000,ko00001,ko01000 formate dehydrogenase (NAD+) activity
MANCPEPA_02188 4.96e-133 yjgB - - S - - - Domain of unknown function (DUF4309)
MANCPEPA_02189 1.38e-59 yjgA - - T - - - Protein of unknown function (DUF2809)
MANCPEPA_02190 1.36e-211 yjfC - - O - - - Predicted Zn-dependent protease (DUF2268)
MANCPEPA_02191 1.13e-29 yjfB - - S - - - Putative motility protein
MANCPEPA_02192 8.68e-106 - - - S - - - Protein of unknown function (DUF2690)
MANCPEPA_02193 0.0 yjeA 3.5.1.104 - G ko:K22278 - ko00000,ko01000 Polysaccharide deacetylase
MANCPEPA_02195 2.16e-223 ctaB 2.5.1.141 - O ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MANCPEPA_02196 1.49e-64 yjdJ - - S - - - Domain of unknown function (DUF4306)
MANCPEPA_02197 6.12e-40 - - - S - - - Domain of unknown function (DUF4177)
MANCPEPA_02198 1.12e-101 ebsC - - S ko:K03976 - ko00000,ko01000,ko03016 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MANCPEPA_02200 5.12e-117 - 2.3.1.128 - J ko:K03790 - ko00000,ko01000,ko03009 Acetyltransferase (GNAT) domain
MANCPEPA_02201 2.95e-72 yjdF3 - - S - - - Protein of unknown function (DUF2992)
MANCPEPA_02202 6.94e-238 manA 5.3.1.8 - G ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 mannose-6-phosphate isomerase
MANCPEPA_02203 0.0 manP 2.7.1.202 - G ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_02204 0.0 manR - - GKT ko:K02538,ko:K03491 - ko00000,ko03000 transcriptional antiterminator
MANCPEPA_02205 6.61e-179 - 1.1.1.100 - IQ ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Enoyl-(Acyl carrier protein) reductase
MANCPEPA_02206 5.19e-61 yjcS - - S - - - Antibiotic biosynthesis monooxygenase
MANCPEPA_02207 2.49e-07 - - - - - - - -
MANCPEPA_02208 3.94e-26 - - - - - - - -
MANCPEPA_02209 1.92e-47 - - - - - - - -
MANCPEPA_02212 5.44e-273 - - - S - - - Bacterial EndoU nuclease
MANCPEPA_02213 6.99e-65 - - - - - - - -
MANCPEPA_02215 2.58e-274 yjcL - - S - - - Protein of unknown function (DUF819)
MANCPEPA_02216 1.62e-124 yjcK 2.3.1.128 - J ko:K03790 - ko00000,ko01000,ko03009 Alanine acetyltransferase
MANCPEPA_02217 1.51e-279 metC 4.4.1.8 - E ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 cystathionine
MANCPEPA_02218 4.65e-272 metB 2.5.1.48 - E ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 cystathionine
MANCPEPA_02219 9.45e-178 yjcH - - P ko:K07214 - ko00000 COG2382 Enterochelin esterase and related enzymes
MANCPEPA_02220 1.2e-121 yjcG - - J - - - Belongs to the 2H phosphoesterase superfamily. YjcG family
MANCPEPA_02221 9.05e-93 yjcF - - S - - - COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_02222 6.31e-51 - - - - - - - -
MANCPEPA_02223 0.0 yjcD 3.6.4.12 - L ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 DNA helicase
MANCPEPA_02224 1.88e-52 spoVIF - - S - - - Stage VI sporulation protein F
MANCPEPA_02227 5.03e-75 yjcA - - S - - - Protein of unknown function (DUF1360)
MANCPEPA_02228 4.71e-66 cotV - - S ko:K06340 - ko00000 Spore Coat Protein X and V domain
MANCPEPA_02229 1.08e-54 cotW - - - ko:K06341 - ko00000 -
MANCPEPA_02230 3.55e-110 cotX - - S ko:K06342 - ko00000 Spore Coat Protein X and V domain
MANCPEPA_02231 3.12e-124 cotY - - S ko:K06343 - ko00000 Spore coat protein Z
MANCPEPA_02232 4.57e-108 cotZ - - S ko:K06344 - ko00000 Spore coat protein
MANCPEPA_02233 1.47e-103 yjbX - - S - - - Spore coat protein
MANCPEPA_02234 1.23e-182 fabI 1.3.1.10, 1.3.1.9 - I ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Enoyl- acyl-carrier-protein reductase NADH
MANCPEPA_02235 8.38e-192 thiD 2.7.1.49, 2.7.4.7 - H ko:K00941 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko00002,ko01000 Phosphomethylpyrimidine kinase
MANCPEPA_02236 1.52e-238 thiF 2.7.7.73, 2.7.7.80 - H ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 ko00000,ko00001,ko01000 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MANCPEPA_02237 6.78e-174 thiG 2.8.1.10 - H ko:K03149 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MANCPEPA_02238 5.35e-42 thiS - - H ko:K03154 ko04122,map04122 ko00000,ko00001 thiamine diphosphate biosynthetic process
MANCPEPA_02239 1.33e-276 thiO 1.4.3.19, 1.4.5.1 - E ko:K00285,ko:K03153 ko00360,ko00730,ko01100,map00360,map00730,map01100 ko00000,ko00001,ko01000 Glycine oxidase
MANCPEPA_02240 2.32e-138 tenI 5.3.99.10 - H ko:K10810 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000,ko03000 Transcriptional regulator TenI
MANCPEPA_02241 5.7e-177 tenA 3.5.99.2 - K ko:K03707 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko01000,ko03000 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MANCPEPA_02242 0.0 yjbQ - - P ko:K03455,ko:K03499 - ko00000,ko02000 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MANCPEPA_02243 8.09e-181 prpE 3.1.3.16, 3.6.1.41 - T ko:K01090,ko:K01525 ko00230,map00230 ko00000,ko00001,ko01000 Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
MANCPEPA_02244 9.4e-206 rluD 5.4.99.23, 5.4.99.28, 5.4.99.29 - J ko:K06177,ko:K06180 - ko00000,ko01000,ko03009,ko03016 Responsible for synthesis of pseudouridine from uracil
MANCPEPA_02245 2.94e-194 nadK 2.7.1.23 - G ko:K00858 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko01000 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MANCPEPA_02246 5.06e-145 yjbM 2.7.6.5 - S ko:K07816 ko00230,map00230 ko00000,ko00001,ko01000 GTP pyrophosphokinase
MANCPEPA_02247 4.41e-80 yjbL - - S - - - Belongs to the UPF0738 family
MANCPEPA_02248 7.02e-128 yjbK - - S - - - protein conserved in bacteria
MANCPEPA_02249 5.38e-124 yjbJ - - M - - - COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MANCPEPA_02250 8.58e-94 yjbI - - S ko:K06886 - ko00000 Bacterial-like globin
MANCPEPA_02251 1.32e-218 yjbH - - Q - - - dithiol-disulfide isomerase involved in polyketide biosynthesis
MANCPEPA_02252 2.68e-28 - - - - - - - -
MANCPEPA_02253 0.0 pepF - - E ko:K08602 - ko00000,ko01000,ko01002 oligoendopeptidase F
MANCPEPA_02254 4.7e-277 coiA - - S ko:K06198 - ko00000 Competence protein
MANCPEPA_02255 4.65e-149 mecA - - NOT ko:K16511 - ko00000 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MANCPEPA_02256 7.1e-144 yjbE - - P - - - Integral membrane protein TerC family
MANCPEPA_02257 1.01e-87 spxA - - K ko:K16509 - ko00000 Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MANCPEPA_02258 8.88e-132 yjbC - - K - - - COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_02259 1.01e-268 yjbB - - EGP - - - Major Facilitator Superfamily
MANCPEPA_02260 4.43e-220 oppF - - E ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02261 3.92e-249 oppD - - P ko:K02031,ko:K15583,ko:K16202 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02262 7.55e-212 oppC - - EP ko:K15582,ko:K16201 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02263 1.03e-212 oppB - - P ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02264 0.0 oppA - - E ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 ABC transporter substrate-binding protein
MANCPEPA_02265 7.18e-234 trpS 6.1.1.2 - J ko:K01867 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Tryptophanyl-tRNA synthetase
MANCPEPA_02266 3.18e-190 yjbA - - S - - - Belongs to the UPF0736 family
MANCPEPA_02267 1.03e-208 appC - - EP ko:K02034 ko02024,map02024 ko00000,ko00001,ko00002,ko02000 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02268 1.04e-219 appB - - P ko:K02033 ko02024,map02024 ko00000,ko00001,ko00002,ko02000 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANCPEPA_02269 0.0 appA - - E ko:K02035 ko02024,map02024 ko00000,ko00001,ko00002,ko02000 COG0747 ABC-type dipeptide transport system, periplasmic component
MANCPEPA_02270 2.07e-237 appF - - E ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02271 6.15e-234 appD - - P ko:K02031,ko:K15583,ko:K16202 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_02272 9.48e-193 yjaZ - - O - - - Zn-dependent protease
MANCPEPA_02273 3.06e-302 fabF 2.3.1.179 - I ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MANCPEPA_02274 1.61e-221 fabH 2.3.1.180 - I ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MANCPEPA_02275 2.67e-38 yjzB - - - - - - -
MANCPEPA_02276 1.07e-35 comZ - - S ko:K02254 - ko00000,ko02044 ComZ
MANCPEPA_02277 6.4e-235 med - - S ko:K05519,ko:K07335 - ko00000,ko03000 Transcriptional activator protein med
MANCPEPA_02278 5.2e-132 yjaV - - - - - - -
MANCPEPA_02279 2.42e-182 yjaU - - I - - - carboxylic ester hydrolase activity
MANCPEPA_02280 1.53e-23 yjzD - - S - - - Protein of unknown function (DUF2929)
MANCPEPA_02281 2.51e-39 yjzC - - S - - - YjzC-like protein
MANCPEPA_02282 3.66e-226 argF 2.1.3.3 - E ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MANCPEPA_02283 0.0 carB 6.3.5.5 - EF ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Carbamoyl-phosphate synthetase ammonia chain
MANCPEPA_02284 2.71e-261 carA 6.3.5.5 - F ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Carbamoyl-phosphate synthetase glutamine chain
MANCPEPA_02285 7.69e-275 argD 2.6.1.11, 2.6.1.17 - E ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 acetylornithine aminotransferase
MANCPEPA_02286 7.35e-175 argB 2.7.2.8 - E ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the acetylglutamate kinase family. ArgB subfamily
MANCPEPA_02287 1.74e-293 argJ 2.3.1.1, 2.3.1.35 - E ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MANCPEPA_02288 7.41e-255 argC 1.2.1.38 - E ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MANCPEPA_02289 3.24e-114 yitZ - - G - - - Major Facilitator Superfamily
MANCPEPA_02290 0.0 yitY - - C - - - D-arabinono-1,4-lactone oxidase
MANCPEPA_02291 1.74e-31 - - - S - - - Proteolipid membrane potential modulator
MANCPEPA_02292 3.26e-68 yitW - - S - - - metal-sulfur cluster biosynthetic enzyme
MANCPEPA_02293 5.05e-185 yitV - - S ko:K06889 - ko00000 COG1073 Hydrolases of the alpha beta superfamily
MANCPEPA_02294 3.19e-200 yitU 3.1.3.104 - S ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 hydrolases of the HAD superfamily
MANCPEPA_02295 1.92e-08 - - - - - - - -
MANCPEPA_02296 1.01e-25 - - - S - - - Protein of unknown function (DUF3813)
MANCPEPA_02297 4.8e-94 ipi - - S - - - Intracellular proteinase inhibitor
MANCPEPA_02298 2.29e-189 yitT - - S - - - Uncharacterized protein conserved in bacteria (DUF2179)
MANCPEPA_02299 6.16e-200 yitS - - S - - - protein conserved in bacteria
MANCPEPA_02300 0.0 nprB 3.4.24.28 - E ko:K01400,ko:K08777 ko02024,map02024 ko00000,ko00001,ko01000,ko01002 Peptidase M4
MANCPEPA_02301 4.59e-59 yitR - - S - - - Domain of unknown function (DUF3784)
MANCPEPA_02302 6.11e-120 - - - - - - - -
MANCPEPA_02303 1.2e-76 - - - K - - - Transcriptional regulator PadR-like family
MANCPEPA_02304 3.29e-127 - - - S - - - Sporulation delaying protein SdpA
MANCPEPA_02305 1.42e-218 - - - - - - - -
MANCPEPA_02306 4.16e-122 - - - - - - - -
MANCPEPA_02307 2.75e-204 yitL - - S ko:K00243 - ko00000 protein conserved in bacteria
MANCPEPA_02308 1.06e-77 yitK - - S ko:K09767 - ko00000 Belongs to the UPF0234 family
MANCPEPA_02309 0.0 yitJ 1.5.1.20, 2.1.1.10 - E ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
MANCPEPA_02310 5.09e-92 - - - S - - - Acetyltransferase (GNAT) domain
MANCPEPA_02311 1.4e-200 yitH - - K - - - Acetyltransferase (GNAT) domain
MANCPEPA_02312 1.01e-291 yitG - - EGP ko:K08221 - ko00000,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_02313 2.14e-283 yitF 5.5.1.27 - M ko:K18983 ko00053,map00053 ko00000,ko00001,ko01000 Belongs to the mandelate racemase muconate lactonizing enzyme family
MANCPEPA_02314 6.77e-145 yitE - - S - - - Uncharacterised 5xTM membrane BCR, YitT family COG1284
MANCPEPA_02315 4.31e-180 yitD 4.4.1.19 - S ko:K08097 ko00680,ko01120,map00680,map01120 ko00000,ko00001,ko00002,ko01000 synthase
MANCPEPA_02316 1.38e-155 - 3.1.3.71 - H ko:K05979 ko00680,ko01120,map00680,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the ComB family
MANCPEPA_02317 3.87e-184 cysH 1.8.4.10, 1.8.4.8 - EH ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Belongs to the PAPS reductase family. CysH subfamily
MANCPEPA_02318 2.66e-293 sat 2.7.7.4 - P ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the sulfate adenylyltransferase family
MANCPEPA_02319 4.06e-145 cysC 2.7.1.25 - P ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the synthesis of activated sulfate
MANCPEPA_02320 2.25e-199 yisY 1.11.1.10 - I ko:K00433 - ko00000,ko01000 hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MANCPEPA_02321 2.15e-96 yisX - - S - - - Pentapeptide repeats (9 copies)
MANCPEPA_02322 0.0 ydfD - - K ko:K18907 - ko00000,ko00002,ko01504,ko03000 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_02323 2.08e-128 argO - - S ko:K06895 - ko00000,ko02000 Lysine exporter protein LysE YggA
MANCPEPA_02324 9.94e-120 yisT - - S - - - DinB family
MANCPEPA_02325 7.35e-249 yisS 1.1.1.18, 1.1.1.369, 1.1.1.370 - S ko:K00010,ko:K16043 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 ko00000,ko00001,ko01000 Oxidoreductase family, C-terminal alpha/beta domain
MANCPEPA_02326 1.06e-234 rbsR - - K ko:K02529,ko:K03484 - ko00000,ko03000 helix_turn _helix lactose operon repressor
MANCPEPA_02327 1.41e-207 yisR - - K - - - Transcriptional regulator
MANCPEPA_02328 2.91e-310 yisQ - - V - - - Mate efflux family protein
MANCPEPA_02329 6.54e-191 crtM 2.5.1.32, 2.5.1.99 - I ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01006 phytoene
MANCPEPA_02330 1.49e-114 yizA - - S - - - Damage-inducible protein DinB
MANCPEPA_02331 0.0 asnO 6.3.5.4 - E ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 ko00000,ko00001,ko01000,ko01002 Asparagine synthase
MANCPEPA_02332 9.03e-133 yisN - - S - - - Protein of unknown function (DUF2777)
MANCPEPA_02333 0.0 wprA - - O ko:K13274 - ko00000,ko01000,ko01002,ko03110 Belongs to the peptidase S8 family
MANCPEPA_02334 2.05e-74 yisL - - S - - - UPF0344 protein
MANCPEPA_02335 1.27e-217 yisK - - Q - - - COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
MANCPEPA_02336 7.04e-218 cotH - - M ko:K06330 - ko00000 Spore Coat
MANCPEPA_02337 1.52e-32 yisI - - S - - - Spo0E like sporulation regulatory protein
MANCPEPA_02338 1.82e-45 gerPA - - S ko:K06299 - ko00000 Spore germination protein
MANCPEPA_02339 1.76e-47 gerPB - - S ko:K06300 - ko00000 cell differentiation
MANCPEPA_02340 8.23e-93 gerPC - - S ko:K06301 - ko00000 Spore germination protein
MANCPEPA_02341 7.36e-34 gerPD - - S ko:K06302 - ko00000 Spore germination protein
MANCPEPA_02342 4.08e-88 gerPE - - S ko:K06303 - ko00000 Spore germination protein GerPE
MANCPEPA_02343 3.3e-43 gerPF - - S ko:K06299,ko:K06304 - ko00000 Spore germination protein gerPA/gerPF
MANCPEPA_02344 6.4e-65 yisB - - V - - - COG1403 Restriction endonuclease
MANCPEPA_02345 0.0 sbcC - - L ko:K03546 - ko00000,ko03400 COG0419 ATPase involved in DNA repair
MANCPEPA_02346 8.08e-280 sbcD - - L ko:K03547 - ko00000,ko03400 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MANCPEPA_02347 0.0 addA 3.6.4.12 - L ko:K16898 - ko00000,ko01000,ko03400 ATP-dependent helicase nuclease subunit A
MANCPEPA_02348 0.0 rexB 3.6.4.12 - L ko:K16899 - ko00000,ko01000,ko03400 ATP-dependent helicase deoxyribonuclease subunit B
MANCPEPA_02349 9.3e-102 yhjR - - S - - - Rubrerythrin
MANCPEPA_02350 0.0 - - - S - - - Sugar transport-related sRNA regulator N-term
MANCPEPA_02351 6.73e-268 - - - EGP - - - Transmembrane secretion effector
MANCPEPA_02352 1.02e-258 yhjN - - S ko:K07120 - ko00000 membrane
MANCPEPA_02353 2.52e-238 yhjM - - K - - - Transcriptional regulator
MANCPEPA_02354 0.0 - 2.6.1.104 - E ko:K18653 - ko00000,ko01000 Belongs to the DegT DnrJ EryC1 family
MANCPEPA_02355 1.52e-204 ntdB 3.1.3.24, 3.1.3.92 - S ko:K07024,ko:K18654 ko00500,map00500 ko00000,ko00001,ko01000 Sucrose-6F-phosphate phosphohydrolase
MANCPEPA_02356 1.14e-256 - 1.1.1.18, 1.1.1.361, 1.1.1.369 - S ko:K00010,ko:K18652 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 ko00000,ko00001,ko01000 Oxidoreductase family, C-terminal alpha/beta domain
MANCPEPA_02357 5.18e-272 glcP - - G ko:K08174 - ko00000,ko02000 Major Facilitator Superfamily
MANCPEPA_02358 3.29e-121 yhjH - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_02359 0.0 yhjG - - CH - - - FAD binding domain
MANCPEPA_02360 5.12e-117 spsB 3.4.21.89 - U ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Belongs to the peptidase S26 family
MANCPEPA_02361 4.87e-141 yhjE - - S - - - SNARE associated Golgi protein
MANCPEPA_02362 2.12e-77 yhjD - - - - - - -
MANCPEPA_02363 1.61e-36 yhjC - - S - - - Protein of unknown function (DUF3311)
MANCPEPA_02364 0.0 yhjB - - E ko:K03307 - ko00000 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANCPEPA_02365 2.04e-56 yhjA - - S - - - Excalibur calcium-binding domain
MANCPEPA_02366 1.48e-215 yhxD - - IQ - - - Enoyl-(Acyl carrier protein) reductase
MANCPEPA_02367 6.29e-141 comK - - K ko:K02250 ko02024,map02024 ko00000,ko00001,ko02044,ko03000 Competence transcription factor
MANCPEPA_02368 9.84e-45 yhzC - - S - - - IDEAL
MANCPEPA_02369 7.82e-204 yhxC - - IQ - - - COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_02370 0.0 yhfW - - CE - - - COG0665 Glycine D-amino acid oxidases (deaminating)
MANCPEPA_02371 1.85e-260 hemAT - - NT ko:K06595 - ko00000,ko02035 chemotaxis protein
MANCPEPA_02372 8.51e-118 bioY - - S ko:K03523 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 BioY family
MANCPEPA_02373 0.0 vraA 6.2.1.3 - IQ ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 AMP-binding enzyme C-terminal domain
MANCPEPA_02374 3e-250 yhfS 2.3.1.9 - I ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the thiolase family
MANCPEPA_02375 3.93e-140 yhfR 5.4.2.12 - G ko:K15634,ko:K15640 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the phosphoglycerate mutase family
MANCPEPA_02376 4.59e-222 yhfQ - - M ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Periplasmic binding protein
MANCPEPA_02377 3.98e-231 yhfP 1.1.1.1 - C ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 ko00000,ko00001,ko01000 Quinone oxidoreductase
MANCPEPA_02378 4.21e-100 - - - K - - - acetyltransferase
MANCPEPA_02379 2.94e-261 aprE 3.4.21.62 - O ko:K01342,ko:K13277 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Belongs to the peptidase S8 family
MANCPEPA_02380 5.34e-305 yhfN - - O - - - Peptidase M48
MANCPEPA_02381 2.78e-85 yhfM - - - - - - -
MANCPEPA_02382 0.0 yhfL 6.2.1.3 - IQ ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 AMP-binding enzyme C-terminal domain
MANCPEPA_02383 2.48e-142 yhfK - - GM - - - NmrA-like family
MANCPEPA_02384 3.34e-244 lplJ 6.3.1.20 - H ko:K03800 ko00785,ko01100,map00785,map01100 ko00000,ko00001,ko01000 Lipoate-protein ligase
MANCPEPA_02385 3.43e-182 yhfI - - S - - - COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
MANCPEPA_02386 4.77e-289 gltT - - C ko:K03309,ko:K11102,ko:K11103 ko02020,map02020 ko00000,ko00001,ko02000 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MANCPEPA_02387 1.53e-93 - - - S - - - ASCH
MANCPEPA_02388 4.44e-252 yhfE - - G - - - peptidase M42
MANCPEPA_02389 1.61e-178 yhfC - - S - - - Putative membrane peptidase family (DUF2324)
MANCPEPA_02390 3.57e-236 fabHB 2.3.1.180 - I ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MANCPEPA_02391 0.0 yhgE - - S ko:K01421 - ko00000 YhgE Pip N-terminal domain protein
MANCPEPA_02392 5.79e-132 yhgD - - K ko:K09017 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_02393 0.0 hemY 1.3.3.15, 1.3.3.4 - H ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MANCPEPA_02394 3.99e-230 hemH 4.99.1.1, 4.99.1.9 - H ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the ferrous insertion into protoporphyrin IX
MANCPEPA_02395 1.06e-258 hemE 4.1.1.37 - H ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko00000,ko00001,ko00002,ko01000 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MANCPEPA_02396 0.0 pbpF 2.4.1.129, 3.4.16.4 GT51 M ko:K12555 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 penicillin-binding protein
MANCPEPA_02397 1.31e-118 traP 1.14.99.57 - S ko:K21481 - ko00000,ko01000 enzyme involved in biosynthesis of extracellular polysaccharides
MANCPEPA_02398 8.22e-44 - - - C - - - Rubrerythrin
MANCPEPA_02399 2.31e-313 yhfA - - C - - - membrane
MANCPEPA_02400 1.27e-290 yhaA - - E ko:K01436 - ko00000,ko01000,ko01002 COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
MANCPEPA_02401 2.04e-161 ecsC - - S - - - EcsC protein family
MANCPEPA_02402 1.27e-271 ecsB - - U ko:K01992 - ko00000,ko00002,ko02000 ABC transporter
MANCPEPA_02403 2.7e-176 ecsA - - V ko:K01990 - ko00000,ko00002,ko02000 transporter (ATP-binding protein)
MANCPEPA_02404 3.5e-106 hit - - FG ko:K02503 - ko00000,ko04147 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MANCPEPA_02405 5.91e-259 serC 2.6.1.52 - E ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MANCPEPA_02406 3.66e-103 trpP - - S - - - Tryptophan transporter TrpP
MANCPEPA_02407 9.66e-30 - - - - - - - -
MANCPEPA_02408 1.74e-54 yhaH - - S - - - YtxH-like protein
MANCPEPA_02409 4.92e-148 hpr - - K ko:K09682 - ko00000,ko03000 Negative regulator of protease production and sporulation
MANCPEPA_02410 8.48e-73 yhaI - - S - - - Protein of unknown function (DUF1878)
MANCPEPA_02411 5.71e-116 yhaK - - S - - - Putative zincin peptidase
MANCPEPA_02412 2.29e-179 prsA 5.2.1.8 - M ko:K01802,ko:K07533 - ko00000,ko01000,ko03110 plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MANCPEPA_02413 1.88e-39 yhaL - - S - - - Sporulation protein YhaL
MANCPEPA_02414 5.22e-228 yhaM - - L ko:K03698 - ko00000,ko01000,ko03019 Shows a 3'-5' exoribonuclease activity
MANCPEPA_02415 0.0 yhaN - - L - - - AAA domain
MANCPEPA_02416 9.05e-299 yhaO - - L ko:K03547 - ko00000,ko03400 DNA repair exonuclease
MANCPEPA_02417 5.14e-272 yhaP - - CP ko:K01992 - ko00000,ko00002,ko02000 COG1668 ABC-type Na efflux pump, permease component
MANCPEPA_02418 5.56e-215 yhaQ - - S ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02419 9.36e-36 - - - S - - - YhzD-like protein
MANCPEPA_02420 7.19e-171 yhaR - - I - - - enoyl-CoA hydratase
MANCPEPA_02422 6.51e-114 - - - P ko:K07228 - ko00000 regulatory, ligand-binding protein related to C-terminal domains of K channels
MANCPEPA_02423 1.85e-267 yhaU - - P ko:K03455 - ko00000 COG0475 Kef-type K transport systems, membrane components
MANCPEPA_02424 0.0 hemZ - - H - - - coproporphyrinogen III oxidase
MANCPEPA_02425 8.7e-198 yhaX - - S - - - haloacid dehalogenase-like hydrolase
MANCPEPA_02426 1.02e-258 yhaZ - - L - - - DNA alkylation repair enzyme
MANCPEPA_02427 7.46e-72 yheA - - S - - - Belongs to the UPF0342 family
MANCPEPA_02428 2.3e-256 yheB - - S - - - Belongs to the UPF0754 family
MANCPEPA_02429 3.37e-276 yheC - - HJ - - - YheC/D like ATP-grasp
MANCPEPA_02430 0.0 yheD - - HJ - - - YheC/D like ATP-grasp
MANCPEPA_02431 2.27e-49 yheE - - S - - - Family of unknown function (DUF5342)
MANCPEPA_02432 1.25e-38 sspB - - S ko:K06418,ko:K06419,ko:K06420 - ko00000 spore protein
MANCPEPA_02433 3.71e-140 yheG - - GM - - - NAD(P)H-binding
MANCPEPA_02434 0.0 yheH - - V ko:K06147,ko:K18217,ko:K18890 ko02010,map02010 ko00000,ko00001,ko00002,ko01504,ko02000 COG1132 ABC-type multidrug transport system, ATPase and permease components
MANCPEPA_02435 0.0 yheI - - V ko:K18216,ko:K18889 ko02010,map02010 ko00000,ko00001,ko00002,ko01504,ko02000 COG1132 ABC-type multidrug transport system, ATPase and permease components
MANCPEPA_02436 1.53e-108 nhaX - - T - - - Belongs to the universal stress protein A family
MANCPEPA_02437 3.61e-303 nhaC - - C ko:K03315 - ko00000,ko02000 Na H antiporter
MANCPEPA_02438 1.5e-195 dat 2.6.1.21 - E ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 ko00000,ko00001,ko01000,ko01007 Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
MANCPEPA_02439 1.63e-199 nodB1 - - G - - - deacetylase
MANCPEPA_02440 1.19e-179 cobB - - K ko:K12410 - ko00000,ko01000 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
MANCPEPA_02441 9.73e-239 yhdY - - M ko:K16052 - ko00000,ko02000 Mechanosensitive ion channel
MANCPEPA_02442 3.7e-09 yhdX - - S - - - Uncharacterized protein YhdX
MANCPEPA_02443 3.68e-172 yhdW 3.1.4.46 - C ko:K01126 ko00564,map00564 ko00000,ko00001,ko01000 glycerophosphoryl diester phosphodiesterase
MANCPEPA_02444 1.67e-86 crcB - - D ko:K06199 - ko00000,ko02000 Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANCPEPA_02445 5.44e-70 crcB - - D ko:K06199 - ko00000,ko02000 Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANCPEPA_02446 0.0 yhdT - - P - - - COG1253 Hemolysins and related proteins containing CBS domains
MANCPEPA_02447 4.19e-283 yhdR 2.6.1.1 - E ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko01000,ko01007 Aminotransferase
MANCPEPA_02448 4.37e-97 cueR - - K ko:K11923 - ko00000,ko03000 transcriptional
MANCPEPA_02449 2.18e-304 yhdP - - S - - - COG1253 Hemolysins and related proteins containing CBS domains
MANCPEPA_02450 3.9e-143 plsC 2.3.1.51 - I ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01004 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MANCPEPA_02451 6.74e-244 yhdN - - C - - - Aldo keto reductase
MANCPEPA_02452 3.24e-113 sigM - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_02453 3.54e-257 yhdL - - S - - - Sigma factor regulator N-terminal
MANCPEPA_02454 4.27e-59 yhdK - - S - - - Sigma-M inhibitor protein
MANCPEPA_02455 1.75e-100 - - - K - - - COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_02456 1.04e-238 ydeL - - K ko:K00375 - ko00000,ko03000 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MANCPEPA_02457 8.29e-308 yhdH - - S ko:K03308 - ko00000 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MANCPEPA_02458 8.94e-317 yhdG - - E ko:K03294 - ko00000 amino acid
MANCPEPA_02459 5.74e-206 yhdF - - IQ - - - COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_02460 1.3e-261 citA 2.3.3.1 - C ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 br01601,ko00000,ko00001,ko00002,ko01000 Belongs to the citrate synthase family
MANCPEPA_02461 4.93e-210 citR - - K ko:K19242 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_02462 7.21e-204 lytE - CBM50 M ko:K19220,ko:K19223,ko:K19224 - ko00000,ko01000,ko01002,ko01011 COG1388 FOG LysM repeat
MANCPEPA_02463 0.0 phoB 3.1.3.1 - P ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Belongs to the alkaline phosphatase family
MANCPEPA_02464 0.0 spoVR - - S ko:K06415 - ko00000 Stage V sporulation protein R
MANCPEPA_02465 1.51e-306 ygxB - - M - - - Conserved TM helix
MANCPEPA_02466 5.58e-99 nsrR - - K ko:K13771 ko05132,map05132 ko00000,ko00001,ko03000 Transcriptional regulator
MANCPEPA_02467 4.84e-275 lytF - CBM50 M ko:K19220,ko:K19223,ko:K19224 - ko00000,ko01000,ko01002,ko01011 COG1388 FOG LysM repeat
MANCPEPA_02468 1.25e-72 yhdC - - S - - - Protein of unknown function (DUF3889)
MANCPEPA_02469 1.65e-51 yhdB - - S - - - YhdB-like protein
MANCPEPA_02470 5.68e-117 yhdA 1.7.1.6 - S ko:K03206 - ko00000,ko01000 NADPH-dependent FMN reductase
MANCPEPA_02471 5.67e-146 yhcZ - - K ko:K02479 - ko00000,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_02472 1.88e-272 yhcY 2.7.13.3 - T ko:K02480 - ko00000,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_02473 0.0 pgcA 5.4.2.2 - G ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Phosphoglucomutase
MANCPEPA_02474 0.0 glpD 1.1.3.21, 1.1.5.3 - C ko:K00105,ko:K00111 ko00564,ko01110,map00564,map01110 ko00000,ko00001,ko01000 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MANCPEPA_02475 0.0 glpK 2.7.1.30 - C ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 ko00000,ko00001,ko01000,ko04147 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MANCPEPA_02476 5.7e-196 glpF - - G ko:K02440 - ko00000,ko02000 Belongs to the MIP aquaporin (TC 1.A.8) family
MANCPEPA_02477 5.35e-135 glpP - - K ko:K02443 - ko00000,ko03000 Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MANCPEPA_02478 0.0 yhxA - - E - - - Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MANCPEPA_02479 0.0 yhcX - - K - - - Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MANCPEPA_02480 2.5e-154 yhcW - - S ko:K07025 - ko00000 hydrolase
MANCPEPA_02481 1.76e-90 yhcV - - S - - - COG0517 FOG CBS domain
MANCPEPA_02482 2.47e-88 yhcU - - S - - - Family of unknown function (DUF5365)
MANCPEPA_02483 6.51e-216 rluA 5.4.99.23, 5.4.99.28, 5.4.99.29 - J ko:K06177,ko:K06180 - ko00000,ko01000,ko03009,ko03016 Responsible for synthesis of pseudouridine from uracil
MANCPEPA_02484 1.25e-134 yhcS 3.4.22.70 - M ko:K07284 - ko00000,ko01000,ko01002,ko01011 COG3764 Sortase (surface protein transpeptidase)
MANCPEPA_02485 0.0 yhcR 3.1.3.5, 3.1.3.6, 3.1.4.16 - F ko:K01081,ko:K01119,ko:K08693 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the 5'-nucleotidase family
MANCPEPA_02486 2.29e-144 yhcQ - - M - - - Spore coat protein
MANCPEPA_02487 6.57e-226 yhcP - - - - - - -
MANCPEPA_02488 2.69e-111 yhcN - - S - - - Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MANCPEPA_02489 1.96e-71 yhcM - - - - - - -
MANCPEPA_02490 2.62e-301 tcyP - - U ko:K06956 - ko00000 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MANCPEPA_02491 1.67e-249 yhcK 2.7.7.65 - T ko:K18967 - ko00000,ko01000,ko02000 COG2199 FOG GGDEF domain
MANCPEPA_02492 2.23e-194 metQ_3 - - M ko:K02073 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the nlpA lipoprotein family
MANCPEPA_02493 1.91e-42 cspB - - K ko:K03704 - ko00000,ko03000 Cold-shock protein
MANCPEPA_02494 2.32e-210 yhcI - - S ko:K01992 - ko00000,ko00002,ko02000 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MANCPEPA_02495 1.85e-212 yhcH - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02496 3.24e-156 yhcG - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02497 4.78e-79 yhcF - - K ko:K07979 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_02498 1.03e-69 - - - - - - - -
MANCPEPA_02499 3.95e-59 yhcC - - - - - - -
MANCPEPA_02500 9.84e-128 yhcB 1.6.5.2 - S ko:K03809 ko00130,ko01110,map00130,map01110 ko00000,ko00001,ko01000 Belongs to the WrbA family
MANCPEPA_02501 0.0 yhcA - - EGP ko:K03446 - ko00000,ko00002,ko02000 the major facilitator superfamily
MANCPEPA_02502 2.67e-133 yhbJ - - V - - - COG1566 Multidrug resistance efflux pump
MANCPEPA_02503 1.29e-101 yhbI - - K ko:K15973 - ko00000,ko03000 DNA-binding transcription factor activity
MANCPEPA_02504 1.21e-286 yhbH - - S ko:K09786 - ko00000 Belongs to the UPF0229 family
MANCPEPA_02505 0.0 prkA - - T ko:K07180 - ko00000 Ser protein kinase
MANCPEPA_02506 4.06e-103 yhbF - - M - - - COG1664 Integral membrane protein CcmA involved in cell shape determination
MANCPEPA_02507 2.66e-95 yhbE - - M - - - COG1664 Integral membrane protein CcmA involved in cell shape determination
MANCPEPA_02508 1.38e-142 yhbD - - K - - - Protein of unknown function (DUF4004)
MANCPEPA_02509 1.08e-111 cspR 2.1.1.207 - J ko:K03216 - ko00000,ko01000,ko03016 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MANCPEPA_02510 9.27e-224 yhbB - - S - - - Putative amidase domain
MANCPEPA_02511 1.7e-283 queG 1.17.99.6 - C ko:K18979 - ko00000,ko01000,ko03016 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MANCPEPA_02512 1.58e-146 yhzB - - S - - - B3/4 domain
MANCPEPA_02514 1.48e-39 - - - K ko:K07729 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_02515 9.35e-101 ygaO - - - - - - -
MANCPEPA_02516 4.64e-53 rpsN - - J ko:K02954 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANCPEPA_02518 9.35e-276 ssuD 1.14.14.28, 1.14.14.5 - C ko:K04091,ko:K20938 ko00920,map00920 ko00000,ko00001,ko01000 Catalyzes the desulfonation of aliphatic sulfonates
MANCPEPA_02519 2.39e-189 ssuC - - P ko:K15554 ko00920,ko02010,map00920,map02010 ko00000,ko00001,ko00002,ko02000 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MANCPEPA_02520 1.99e-216 ssuA - - M ko:K15553 ko00920,ko02010,map00920,map02010 ko00000,ko00001,ko00002,ko02000 Sulfonate ABC transporter
MANCPEPA_02521 7.1e-176 ssuB - - P ko:K15555 ko00920,ko02010,map00920,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
MANCPEPA_02522 0.0 katA 1.11.1.6 - P ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 ko00000,ko00001,ko00002,ko01000 serves to protect cells from the toxic effects of hydrogen peroxide
MANCPEPA_02524 0.0 ygaK - - C - - - Berberine and berberine like
MANCPEPA_02525 0.0 thiC 4.1.99.17 - H ko:K03147 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MANCPEPA_02526 4.02e-172 ygaJ 3.4.13.21 - E ko:K05995 - ko00000,ko01000,ko01002 Belongs to the peptidase S51 family
MANCPEPA_02527 3.88e-37 - - - - - - - -
MANCPEPA_02528 2.22e-185 spo0M - - S ko:K06377 - ko00000 COG4326 Sporulation control protein
MANCPEPA_02545 6.35e-53 cydC - - V ko:K16013 ko02010,map02010 ko00000,ko00001,ko02000 ATP-binding
MANCPEPA_02546 0.0 cydD - - V ko:K16012 ko02010,map02010 ko00000,ko00001,ko02000 ATP-binding protein
MANCPEPA_02547 7.23e-200 nnrD 4.2.1.136, 5.1.99.6 - G ko:K17758,ko:K17759 - ko00000,ko01000 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MANCPEPA_02548 0.0 yxlA - - F ko:K03457 - ko00000 Belongs to the purine-cytosine permease (2.A.39) family
MANCPEPA_02549 1.29e-124 sigY - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_02550 2.34e-63 yxlC - - S - - - Family of unknown function (DUF5345)
MANCPEPA_02551 2.92e-42 - - - - - - - -
MANCPEPA_02552 2.17e-39 yxlE - - S - - - Phospholipase_D-nuclease N-terminal
MANCPEPA_02553 3.89e-209 yxlF - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02554 3.12e-176 yxlG - - S ko:K01992 - ko00000,ko00002,ko02000 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MANCPEPA_02555 5.13e-269 yxlH - - EGP - - - Major Facilitator Superfamily
MANCPEPA_02556 0.0 katX 1.11.1.6 - P ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 ko00000,ko00001,ko00002,ko01000 serves to protect cells from the toxic effects of hydrogen peroxide
MANCPEPA_02557 1.87e-144 yxlJ 3.2.2.21 - L ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Belongs to the DNA glycosylase MPG family
MANCPEPA_02558 8.94e-28 yxzF - - - - - - -
MANCPEPA_02559 0.0 licR - - GKT ko:K03491 - ko00000,ko03000 Mga helix-turn-helix domain
MANCPEPA_02560 1.89e-67 licB 2.7.1.196, 2.7.1.205 - G ko:K02760 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 transporter subunit IIB
MANCPEPA_02561 0.0 licC - - G ko:K02761 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko02000 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MANCPEPA_02562 9.17e-50 licA 2.7.1.196, 2.7.1.205 - G ko:K02759 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_02563 0.0 licH 3.2.1.86 GT4 G ko:K01222 ko00010,ko00500,map00010,map00500 ko00000,ko00001,ko01000 COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MANCPEPA_02564 3.07e-263 ilvE 2.6.1.42 - E ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000,ko01007 Branched-chain amino acid aminotransferase
MANCPEPA_02565 6.86e-177 dltE - - M ko:K14189 - ko00000,ko01000 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_02566 4.09e-294 dltD - - M ko:K03740 ko01503,ko02020,ko05150,map01503,map02020,map05150 ko00000,ko00001,ko00002,ko01504 COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MANCPEPA_02567 6.83e-50 dltC 6.1.1.13 - IQ ko:K14188 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 ko00000,ko00001,ko00002,ko01000,ko01504 Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_02568 1.14e-297 dltB - - M ko:K03739 ko01503,ko02020,ko05150,map01503,map02020,map05150 ko00000,ko00001,ko00002,ko01504 membrane protein involved in D-alanine export
MANCPEPA_02569 0.0 dltA 6.1.1.13 - Q ko:K03367 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 ko00000,ko00001,ko00002,ko01000,ko01504 Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_02570 4.89e-211 menA 2.5.1.74 - H ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01006 Belongs to the MenA family. Type 1 subfamily
MANCPEPA_02571 2.52e-149 ywaC 2.7.6.5 - S ko:K00951,ko:K07816 ko00230,map00230 ko00000,ko00001,ko01000 protein conserved in bacteria
MANCPEPA_02572 2.79e-165 - - - EGP - - - Permeases of the major facilitator superfamily
MANCPEPA_02573 3.23e-63 - 4.1.1.44 - S ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 ko00000,ko00001,ko01000 Carboxymuconolactone decarboxylase family
MANCPEPA_02574 1.08e-115 - - - K - - - Helix-turn-helix XRE-family like proteins
MANCPEPA_02575 1.83e-316 ywaD 3.4.11.10, 3.4.11.6 - S ko:K19701 - ko00000,ko01000,ko01002 PA domain
MANCPEPA_02576 2.22e-297 tyrS 6.1.1.1 - J ko:K01866 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MANCPEPA_02577 1.25e-114 ywaE - - K - - - Transcriptional regulator
MANCPEPA_02578 6.04e-159 ywaF - - S - - - Integral membrane protein
MANCPEPA_02579 5.37e-216 gspA - - M - - - General stress
MANCPEPA_02580 3.39e-191 sacT - - K ko:K03488 - ko00000,ko03000 transcriptional antiterminator
MANCPEPA_02581 1.45e-312 sacX 2.7.1.211 - G ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_02582 0.0 epr 3.4.21.62 - O ko:K01342,ko:K13277 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Belongs to the peptidase S8 family
MANCPEPA_02583 3e-310 licC - - G ko:K02761 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko02000 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MANCPEPA_02584 9.79e-159 ywbB - - S - - - Protein of unknown function (DUF2711)
MANCPEPA_02585 6.24e-121 - - - N - - - domain, Protein
MANCPEPA_02586 3.3e-86 ywbC 4.4.1.5 - E ko:K01759 ko00620,map00620 ko00000,ko00001,ko01000 glyoxalase
MANCPEPA_02587 3.29e-279 ywbD 2.1.1.191 - J ko:K06969 - ko00000,ko01000,ko03009 Methyltransferase
MANCPEPA_02588 3.13e-38 ywbE - - S - - - Uncharacterized conserved protein (DUF2196)
MANCPEPA_02589 4.13e-275 ywbF - - EGP ko:K05820 - ko00000,ko02000 Nucleoside H+ symporter
MANCPEPA_02590 1.21e-143 ywbG - - M - - - effector of murein hydrolase
MANCPEPA_02591 1.1e-76 ywbH - - S ko:K06518 - ko00000,ko02000 Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
MANCPEPA_02592 2.7e-203 ywbI - - K - - - Transcriptional regulator
MANCPEPA_02593 1.32e-184 thiM 2.7.1.50 - H ko:K00878 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MANCPEPA_02594 1e-145 thiE 2.5.1.3 - H ko:K00788 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko00002,ko01000 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MANCPEPA_02595 0.0 - - - P ko:K07243 - ko00000,ko02000 COG0672 High-affinity Fe2 Pb2 permease
MANCPEPA_02596 6.21e-249 ycdO - - P ko:K07224 - ko00000,ko02000 periplasmic lipoprotein involved in iron transport
MANCPEPA_02597 3.23e-310 ywbN - - P ko:K07223,ko:K16301 - ko00000,ko01000,ko02000 Dyp-type peroxidase family protein
MANCPEPA_02598 1.08e-145 ywbO - - Q - - - dithiol-disulfide isomerase involved in polyketide biosynthesis
MANCPEPA_02599 0.0 ywcA - - S ko:K14393 - ko00000,ko02000 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANCPEPA_02600 1.23e-63 ywcB - - S - - - Protein of unknown function, DUF485
MANCPEPA_02602 4.16e-159 ywcC - - K - - - transcriptional regulator
MANCPEPA_02603 3.33e-77 gtcA - - S - - - GtrA-like protein
MANCPEPA_02604 5.56e-291 galK 2.7.1.6 - G ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MANCPEPA_02605 0.0 galT 2.7.7.12 - G ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 ko00000,ko00001,ko00002,ko01000 UDP-glucose--hexose-1-phosphate uridylyltransferase
MANCPEPA_02606 5.11e-49 ydaS - - S - - - membrane
MANCPEPA_02607 6.94e-226 qoxA 1.10.3.12 - C ko:K02826 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
MANCPEPA_02608 0.0 qoxB 1.10.3.12 - C ko:K02827 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MANCPEPA_02609 1.2e-144 qoxC 1.10.3.12 - C ko:K02828 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 quinol oxidase, subunit
MANCPEPA_02610 1.12e-83 qoxD 1.10.3.12 - C ko:K02829 ko00190,ko01100,map00190,map01100 ko00000,ko00001,ko00002,ko01000 quinol oxidase, subunit
MANCPEPA_02611 6.61e-52 ywcE - - S - - - Required for proper spore morphogenesis. Important for spore germination
MANCPEPA_02612 1.26e-268 rodA - - D ko:K05837 - ko00000,ko03036 Belongs to the SEDS family
MANCPEPA_02613 1.98e-179 nfrA1 1.5.1.38 - C ko:K19285 ko00740,ko01100,map00740,map01100 ko00000,ko00001,ko01000 Oxidoreductase
MANCPEPA_02614 4.19e-239 ywcH - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_02615 0.0 prtS 3.4.21.110, 3.4.21.96 - O ko:K01361,ko:K08652,ko:K14647 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Belongs to the peptidase S8 family
MANCPEPA_02617 1.29e-193 sacT - - K ko:K03488 - ko00000,ko03000 transcriptional antiterminator
MANCPEPA_02618 2.91e-180 - - - P ko:K02598 - ko00000,ko02000 Formate/nitrite transporter
MANCPEPA_02619 0.0 sacP 2.7.1.211 - G ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_02620 0.0 sacA 3.2.1.26 GH32 G ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 ko00000,ko00001,ko01000 invertase
MANCPEPA_02621 6.19e-39 ywdA - - - - - - -
MANCPEPA_02622 5.43e-188 pdxK 2.7.1.35, 2.7.1.49, 2.7.4.7 - H ko:K00868,ko:K00941 ko00730,ko00750,ko01100,map00730,map00750,map01100 ko00000,ko00001,ko00002,ko01000 Phosphomethylpyrimidine kinase
MANCPEPA_02623 1.57e-190 ywdF - - S - - - Glycosyltransferase like family 2
MANCPEPA_02624 2.32e-166 ung 3.2.2.27 - L ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MANCPEPA_02625 0.0 ywdH 1.2.1.3 - C ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the aldehyde dehydrogenase family
MANCPEPA_02626 2.18e-63 ywdI - - S - - - Family of unknown function (DUF5327)
MANCPEPA_02627 1.86e-303 ywdJ - - F - - - Xanthine uracil
MANCPEPA_02628 1.59e-78 ywdK - - S - - - small membrane protein
MANCPEPA_02629 3.62e-112 gerQ - - S ko:K06305 - ko00000 Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
MANCPEPA_02630 8.08e-187 spsA - - M - - - Spore Coat
MANCPEPA_02631 0.0 spsB - - M - - - Capsule polysaccharide biosynthesis protein
MANCPEPA_02632 1.52e-283 spsC 2.6.1.102 - E ko:K13010 ko00520,map00520 ko00000,ko00001,ko01000,ko01005,ko01007 Belongs to the DegT DnrJ EryC1 family
MANCPEPA_02633 4.22e-210 spsD 2.3.1.210 - K ko:K16704 - ko00000,ko01000 Spore Coat
MANCPEPA_02634 4.4e-268 pseI 2.5.1.56, 2.5.1.97 - M ko:K01654,ko:K15898 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 acid synthase
MANCPEPA_02635 3.51e-164 spsF - - M ko:K07257 - ko00000 Spore Coat
MANCPEPA_02636 1.11e-237 spsG - - M - - - Spore Coat
MANCPEPA_02637 3.04e-177 spsI 2.7.7.24 - M ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MANCPEPA_02638 3.04e-232 spsJ 4.2.1.46 - M ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MANCPEPA_02639 7.82e-203 rfbD 1.1.1.133 - M ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MANCPEPA_02640 9.16e-114 spsL 5.1.3.13 - M ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 ko00000,ko00001,ko00002,ko01000 Spore Coat
MANCPEPA_02641 3.7e-101 - - - - - - - -
MANCPEPA_02642 5.19e-311 rocG 1.4.1.2 - E ko:K00260 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 ko00000,ko00001,ko01000 Belongs to the Glu Leu Phe Val dehydrogenases family
MANCPEPA_02643 0.0 rocA 1.2.1.88 - C ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 ko00000,ko00001,ko01000 Belongs to the aldehyde dehydrogenase family. RocA subfamily
MANCPEPA_02644 0.0 rocB - - E - - - arginine degradation protein
MANCPEPA_02645 1.06e-315 rocC - - E ko:K02205,ko:K16235,ko:K16236 - ko00000,ko02000 amino acid
MANCPEPA_02646 1.09e-274 ywfA - - EGP - - - -transporter
MANCPEPA_02647 5.11e-146 bacA 4.1.1.100 - E ko:K19546 ko01130,map01130 ko00000,ko00001,ko00002,ko01000 Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
MANCPEPA_02648 1.24e-175 bacB 5.3.3.19 - S ko:K19547 ko01130,map01130 ko00000,ko00001,ko00002,ko01000 Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
MANCPEPA_02649 1.56e-178 bacC 1.1.1.385 - IQ ko:K19548 ko01130,map01130 ko00000,ko00001,ko00002,ko01000 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_02650 0.0 bacD 6.3.2.49 - F ko:K13037 ko01130,map01130 ko00000,ko00001,ko00002,ko01000 Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
MANCPEPA_02651 1.85e-266 bacE - - EGP ko:K19552 - ko00000,ko02000 Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic
MANCPEPA_02652 1.74e-294 ywfG - - E ko:K08969,ko:K19549 ko00270,ko01100,ko01130,map00270,map01100,map01130 ko00000,ko00001,ko00002,ko01000,ko01007 Aminotransferase class I and II
MANCPEPA_02653 2.37e-176 ywfH - - IQ ko:K19550 ko01130,map01130 ko00000,ko00001,ko00002,ko01000 Enoyl-(Acyl carrier protein) reductase
MANCPEPA_02654 3.43e-187 ywfI - - C ko:K00435 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko00000,ko00001,ko01000 May function as heme-dependent peroxidase
MANCPEPA_02655 6.8e-224 pta 2.3.1.8, 3.6.3.21 - C ko:K00625,ko:K02028 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000,ko02000 In Salmonella this enzyme is required for ethanolamine catabolism
MANCPEPA_02656 3.73e-209 cysL - - K ko:K21900 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_02657 2.51e-198 lipL 2.3.1.200, 2.3.1.204 - H ko:K16869,ko:K18821 - ko00000,ko01000 Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
MANCPEPA_02658 3.69e-201 ywfM - - EG ko:K03298 - ko00000,ko02000 EamA-like transporter family
MANCPEPA_02659 5.39e-145 rsfA_1 - - - ko:K06314 - ko00000,ko03000 -
MANCPEPA_02660 8.55e-49 ywzC - - S - - - Belongs to the UPF0741 family
MANCPEPA_02661 0.0 ywfO - - S ko:K06885 - ko00000 COG1078 HD superfamily phosphohydrolases
MANCPEPA_02662 1.47e-115 ywgA - - - ko:K09388 - ko00000 -
MANCPEPA_02663 3.68e-102 yffB - - K - - - Transcriptional regulator
MANCPEPA_02664 3.31e-301 mmr - - U ko:K08166 - ko00000,ko02000 Major Facilitator Superfamily
MANCPEPA_02666 0.0 thrS 6.1.1.3 - J ko:K01868 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MANCPEPA_02667 1.45e-93 ywhA - - K - - - Transcriptional regulator
MANCPEPA_02668 1.43e-35 dmpI 5.3.2.6 - G ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 ko00000,ko00001,ko00002,ko01000 4-oxalocrotonate tautomerase
MANCPEPA_02669 3.29e-154 ywhC - - S - - - Peptidase family M50
MANCPEPA_02670 2.24e-122 ywhD - - S - - - YwhD family
MANCPEPA_02671 0.0 pbpG 2.4.1.129, 3.4.16.4 GT51 M ko:K21464 ko00550,map00550 ko00000,ko00001,ko01000,ko01003,ko01011 penicillin-binding protein
MANCPEPA_02672 1.93e-204 speE 2.5.1.16 - E ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MANCPEPA_02673 2.1e-215 speB 3.5.3.11 - E ko:K01480 ko00330,ko01100,map00330,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the arginase family
MANCPEPA_02675 1.4e-74 - - - V ko:K01990 - ko00000,ko00002,ko02000 ATPases associated with a variety of cellular activities
MANCPEPA_02678 1.3e-10 - - - - - - - -
MANCPEPA_02682 1.64e-99 rapA1 - - S ko:K06359,ko:K06361 ko02024,map02024 ko00000,ko00001,ko01000 aspartate phosphatase
MANCPEPA_02683 9.47e-275 ywhK - - CO - - - amine dehydrogenase activity
MANCPEPA_02684 1.4e-314 ywhL - - CO - - - amine dehydrogenase activity
MANCPEPA_02686 2.93e-316 - - - L - - - Peptidase, M16
MANCPEPA_02687 5.09e-278 - 2.7.1.26, 2.7.7.2 - L ko:K07263,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko01002 Peptidase, M16
MANCPEPA_02688 1.07e-300 mgtA 3.6.3.2 - P ko:K01531,ko:K16905 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ATPase, P-type transporting, HAD superfamily, subfamily IC
MANCPEPA_02689 1.5e-169 - - - V ko:K01990 - ko00000,ko00002,ko02000 ABC transporter
MANCPEPA_02691 0.0 - - - C ko:K22227 - ko00000 Fe-S oxidoreductases
MANCPEPA_02692 3.71e-12 - - - S - - - Bacteriocin subtilosin A
MANCPEPA_02693 4.64e-96 ywiB - - S - - - protein conserved in bacteria
MANCPEPA_02694 0.0 argS 6.1.1.19 - J ko:K01887 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Arginyl-tRNA synthetase
MANCPEPA_02695 3.39e-274 narK - - P ko:K02575 ko00910,map00910 ko00000,ko00001,ko00002,ko02000 COG2223 Nitrate nitrite transporter
MANCPEPA_02696 2.3e-168 fnr - - K - - - helix_turn_helix, cAMP Regulatory protein
MANCPEPA_02697 1.84e-179 ywiC - - S - - - YwiC-like protein
MANCPEPA_02698 8.67e-111 arfM - - T ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 cyclic nucleotide binding
MANCPEPA_02699 0.0 narG 1.7.5.1 - C ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 ko00000,ko00001,ko00002,ko01000 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MANCPEPA_02700 0.0 narH 1.7.5.1 - C ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 ko00000,ko00001,ko00002,ko01000 Nitrate reductase, beta
MANCPEPA_02701 2.28e-121 narJ - - C ko:K00373 ko02020,map02020 ko00000,ko00001 nitrate reductase
MANCPEPA_02702 2.06e-159 narI 1.7.5.1 - C ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 ko00000,ko00001,ko00002,ko01000 Nitrate reductase (gamma
MANCPEPA_02703 0.0 ywiE - - I ko:K06131 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MANCPEPA_02704 0.0 ywjA - - V ko:K06147 - ko00000,ko02000 ABC transporter
MANCPEPA_02705 1.35e-124 ywjB - - H - - - RibD C-terminal domain
MANCPEPA_02706 1.32e-57 ywjC - - - - - - -
MANCPEPA_02707 2.32e-234 uvsE - - L ko:K13281 - ko00000,ko01000 Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
MANCPEPA_02708 4.95e-289 clsB - - I ko:K06131 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 Belongs to the phospholipase D family. Cardiolipin synthase subfamily
MANCPEPA_02709 0.0 ywjF - - C - - - COG0247 Fe-S oxidoreductase
MANCPEPA_02710 1.21e-268 acdA - - I - - - acyl-CoA dehydrogenase
MANCPEPA_02711 1.03e-82 rpoE - - K ko:K03048 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 br01611,ko00000,ko00001,ko00002,ko03021,ko03400 Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MANCPEPA_02712 0.0 pyrG 6.3.4.2 - F ko:K01937 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MANCPEPA_02713 9.11e-118 ywjG - - S - - - Domain of unknown function (DUF2529)
MANCPEPA_02714 1.07e-81 spo0F - - T ko:K02490 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko02022 COG0784 FOG CheY-like receiver
MANCPEPA_02715 7.82e-204 fbaA 4.1.2.13, 4.1.2.29 - G ko:K01624,ko:K03339 ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Aldolase
MANCPEPA_02716 5.69e-147 tal 2.2.1.2 - G ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MANCPEPA_02717 2.26e-303 murA 2.5.1.7 - M ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 ko00000,ko00001,ko01000,ko01011 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MANCPEPA_02718 3.51e-225 glpX 3.1.3.11 - G ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 fructose-1,6-bisphosphatase
MANCPEPA_02719 5.53e-303 rho - - K ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MANCPEPA_02720 7e-45 rpmE - - J ko:K02909 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds the 23S rRNA
MANCPEPA_02721 9.96e-135 tdk 2.7.1.21 - F ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 ko00000,ko00001,ko01000 thymidine kinase
MANCPEPA_02722 0.0 ykwA 1.1.1.38 - C ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 ko00000,ko00001,ko01000 malic enzyme
MANCPEPA_02723 3.24e-204 ywkB - - S ko:K07088 - ko00000 Membrane transport protein
MANCPEPA_02724 6.01e-117 racA - - K ko:K11686 - ko00000,ko03036 Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
MANCPEPA_02725 9.41e-87 ywkD - - E ko:K08234 - ko00000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_02726 9.95e-245 prfA - - J ko:K02835 - ko00000,ko03012 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MANCPEPA_02727 5.96e-205 prmC 2.1.1.297 - J ko:K02493 - ko00000,ko01000,ko03012 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MANCPEPA_02729 9.69e-74 ywlA - - S - - - Uncharacterised protein family (UPF0715)
MANCPEPA_02730 9.35e-152 spoIIR - - S ko:K06387 - ko00000 stage II sporulation protein R
MANCPEPA_02731 2.55e-100 ywlB - - E - - - Belongs to the acetyltransferase family. ArgA subfamily
MANCPEPA_02732 3e-250 ywlC 2.7.7.87 - J ko:K07566 - ko00000,ko01000,ko03009,ko03016 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MANCPEPA_02733 4.56e-117 mntP - - P - - - Probably functions as a manganese efflux pump
MANCPEPA_02734 1.58e-100 ywlE 3.1.3.48, 3.9.1.2 - T ko:K01104,ko:K20201 - ko00000,ko01000 Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MANCPEPA_02735 2.35e-106 rpiB 5.3.1.6 - G ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Ribose 5-phosphate isomerase
MANCPEPA_02736 2.49e-123 ywlG - - S - - - Belongs to the UPF0340 family
MANCPEPA_02737 1.25e-302 glyA 2.1.2.1 - E ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 ko00000,ko00001,ko00002,ko01000 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MANCPEPA_02738 5.5e-148 upp 2.4.2.9 - F ko:K00761 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko01000 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MANCPEPA_02739 1.91e-81 atpI - - S ko:K02116 - ko00000,ko00194 ATP synthase
MANCPEPA_02740 6.06e-167 atpB - - C ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194,ko03110 it plays a direct role in the translocation of protons across the membrane
MANCPEPA_02741 3.01e-36 atpE - - C ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MANCPEPA_02742 2.62e-79 atpF - - C ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MANCPEPA_02743 1.18e-117 atpH - - C ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MANCPEPA_02744 0.0 atpA 3.6.3.14 - C ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194,ko01000 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MANCPEPA_02745 4.46e-195 atpG - - C ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MANCPEPA_02746 0.0 atpD 3.6.3.14 - C ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194,ko01000 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MANCPEPA_02747 2.44e-75 atpC - - C ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 ko00000,ko00001,ko00002,ko00194 Produces ATP from ADP in the presence of a proton gradient across the membrane
MANCPEPA_02748 8.36e-113 ywmA - - - - - - -
MANCPEPA_02749 4.54e-45 ywzB - - S - - - membrane
MANCPEPA_02750 1.81e-169 ywmB - - S - - - TATA-box binding
MANCPEPA_02751 4.96e-306 murA 2.5.1.7 - M ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 ko00000,ko00001,ko01000,ko01011 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MANCPEPA_02752 9.77e-234 spoIID - - D ko:K06381 - ko00000 Stage II sporulation protein D
MANCPEPA_02753 1.89e-157 ywmC - - S ko:K07114 - ko00000,ko02000 protein containing a von Willebrand factor type A (vWA) domain
MANCPEPA_02754 1.02e-155 ywmD - - S ko:K07114 - ko00000,ko02000 protein containing a von Willebrand factor type A (vWA) domain
MANCPEPA_02756 3.69e-186 fdhD - - C ko:K02379 - ko00000 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MANCPEPA_02757 1.08e-245 moaA 4.1.99.22 - H ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 ko00000,ko00001,ko01000 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MANCPEPA_02758 1.25e-128 rapA - - S ko:K06359,ko:K06360,ko:K06367 ko02024,map02024 ko00000,ko00001,ko01000 Response regulator aspartate phosphatase
MANCPEPA_02759 1.12e-109 ywmF - - S - - - Peptidase M50
MANCPEPA_02760 1.84e-20 csbD - - K - - - CsbD-like
MANCPEPA_02761 8.2e-68 ureA 3.5.1.5 - E ko:K01430 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 ko00000,ko00001,ko01000 Belongs to the urease gamma subunit family
MANCPEPA_02762 1.12e-83 ureB 3.5.1.5 - E ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 ko00000,ko00001,ko01000 Belongs to the urease beta subunit family
MANCPEPA_02763 0.0 ureC 3.5.1.5 - E ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 ko00000,ko00001,ko01000 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
MANCPEPA_02764 9.24e-85 ywnA - - K - - - Transcriptional regulator
MANCPEPA_02765 4.32e-147 ywnB - - S ko:K07118 - ko00000 NAD(P)H-binding
MANCPEPA_02766 1.06e-78 ywnC - - S - - - Family of unknown function (DUF5362)
MANCPEPA_02767 2.69e-181 mta - - K ko:K21743 - ko00000,ko03000 transcriptional
MANCPEPA_02768 0.0 ywnE - - I ko:K06131 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MANCPEPA_02769 7.07e-92 ywnF - - S - - - Family of unknown function (DUF5392)
MANCPEPA_02770 4.64e-22 ywnC - - S - - - Family of unknown function (DUF5362)
MANCPEPA_02771 1.49e-114 ywnH 2.3.1.183 - M ko:K03823 ko00440,ko01130,map00440,map01130 ko00000,ko00001,ko01000 COG1247 Sortase and related acyltransferases
MANCPEPA_02772 1.85e-161 spoIIQ - - M ko:K06386 - ko00000 COG0739 Membrane proteins related to metalloendopeptidases
MANCPEPA_02773 4.31e-91 ywnJ - - S - - - VanZ like family
MANCPEPA_02774 1.21e-134 bcrC 3.6.1.27 - I ko:K19302 ko00550,map00550 ko00000,ko00001,ko01000,ko01011 COG0671 Membrane-associated phospholipid phosphatase
MANCPEPA_02775 4.51e-77 nrgB - - K ko:K04751 ko02020,map02020 ko00000,ko00001 Belongs to the P(II) protein family
MANCPEPA_02776 3.22e-288 nrgA - - P ko:K03320 - ko00000,ko02000 Ammonium transporter
MANCPEPA_02777 4.84e-99 - - - - - - - -
MANCPEPA_02778 2.11e-133 yjgF - - Q - - - Isochorismatase family
MANCPEPA_02779 3.11e-306 ywoD - - EGP - - - Major facilitator superfamily
MANCPEPA_02780 0.0 - - - FH ko:K03457,ko:K10975 - ko00000,ko02000 COG1953 Cytosine uracil thiamine allantoin permeases
MANCPEPA_02781 2.4e-311 ywoF - - P - - - Right handed beta helix region
MANCPEPA_02782 5.56e-269 ywoG - - EGP - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_02783 8.45e-92 - - - K - - - COG1846 Transcriptional regulators
MANCPEPA_02784 4.88e-59 spoIIID - - K ko:K06283 - ko00000,ko03000 Stage III sporulation protein D
MANCPEPA_02785 1.75e-231 mbl - - D ko:K03569 - ko00000,ko02048,ko03036,ko04812 Rod shape-determining protein
MANCPEPA_02786 1.77e-172 flhO - - N ko:K02392 ko02040,map02040 ko00000,ko00001,ko02035 flagellar basal body
MANCPEPA_02787 3.37e-181 flhP - - N ko:K02392 ko02040,map02040 ko00000,ko00001,ko02035 flagellar basal body
MANCPEPA_02788 1.5e-254 rapD - - S ko:K06362 - ko00000,ko01000 aspartate phosphatase
MANCPEPA_02789 6.89e-107 fabZ 4.2.1.59 - I ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MANCPEPA_02790 1.61e-77 mscL - - M ko:K03282 - ko00000,ko02000 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MANCPEPA_02791 3.42e-188 ywpD - - T - - - Histidine kinase
MANCPEPA_02792 4.46e-66 srtA 3.4.22.70 - M ko:K07284 - ko00000,ko01000,ko01002,ko01011 Sortase family
MANCPEPA_02793 8.81e-89 ywpF - - S - - - YwpF-like protein
MANCPEPA_02794 3.04e-87 ywpG - - - - - - -
MANCPEPA_02795 3.48e-75 ssbB - - L ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Single-stranded DNA-binding protein
MANCPEPA_02796 4.82e-180 glcR - - K ko:K22103 - ko00000,ko03000 COG1349 Transcriptional regulators of sugar metabolism
MANCPEPA_02797 8.4e-199 ywpJ 3.1.3.104 - S ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 hydrolases of the HAD superfamily
MANCPEPA_02798 0.0 ywqA - - L - - - COG0553 Superfamily II DNA RNA helicases, SNF2 family
MANCPEPA_02799 0.0 ywqB - - S - - - SWIM zinc finger
MANCPEPA_02800 3.6e-25 - - - - - - - -
MANCPEPA_02801 5.33e-163 ywqC - - M ko:K19420 - ko00000 biosynthesis protein
MANCPEPA_02802 1.06e-152 ywqD 2.7.10.2 - D ko:K00903 - ko00000,ko01000,ko01001 COG0489 ATPases involved in chromosome partitioning
MANCPEPA_02803 1.18e-178 ywqE 3.1.3.48 - GM ko:K01104 - ko00000,ko01000 COG4464 Capsular polysaccharide biosynthesis protein
MANCPEPA_02804 1.34e-312 ywqF 1.1.1.22 - M ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MANCPEPA_02805 1.71e-195 ywqG - - S - - - Domain of unknown function (DUF1963)
MANCPEPA_02807 2.09e-50 ywqI - - S - - - Family of unknown function (DUF5344)
MANCPEPA_02808 3.54e-303 ywqJ - - S - - - Pre-toxin TG
MANCPEPA_02810 7.19e-149 nfi 3.1.21.7 - L ko:K05982 - ko00000,ko01000,ko03400 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
MANCPEPA_02811 3.89e-208 - - - K - - - Transcriptional regulator
MANCPEPA_02812 5.23e-130 ywqN - - S - - - NAD(P)H-dependent
MANCPEPA_02814 4.27e-114 ywrA - - P ko:K07240 - ko00000,ko02000 COG2059 Chromate transport protein ChrA
MANCPEPA_02815 4.53e-132 ywrB - - P ko:K07240 - ko00000,ko02000 Chromate transporter
MANCPEPA_02816 2.79e-107 ywrC - - K ko:K03719 - ko00000,ko03000,ko03036 Transcriptional regulator
MANCPEPA_02817 0.0 ywrD 2.3.2.2, 3.4.19.13 - E ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 ko00000,ko00001,ko01000,ko01002 gamma-glutamyltransferase
MANCPEPA_02818 1.22e-09 - - - S - - - Domain of unknown function (DUF4181)
MANCPEPA_02819 4.35e-143 ywrF - - S - - - COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MANCPEPA_02820 2.17e-16 - - - - - - - -
MANCPEPA_02821 2.64e-268 cotH - - M ko:K06330 - ko00000 Spore Coat
MANCPEPA_02822 5.9e-177 cotB - - - ko:K06325 - ko00000 -
MANCPEPA_02823 3.04e-162 ywrJ - - - - - - -
MANCPEPA_02824 9.73e-281 ywrK - - P ko:K03893 - ko00000,ko02000 Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MANCPEPA_02825 3.36e-218 alsR - - K - - - LysR substrate binding domain
MANCPEPA_02826 0.0 alsS 2.2.1.6 - EH ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the TPP enzyme family
MANCPEPA_02827 1.84e-187 budA 4.1.1.5 - H ko:K01575 ko00650,ko00660,map00650,map00660 ko00000,ko00001,ko01000 Alpha-acetolactate decarboxylase
MANCPEPA_02828 8.76e-126 ywrO - - S - - - NADPH-quinone reductase (modulator of drug activity B)
MANCPEPA_02829 3.75e-63 ywsA - - S - - - Protein of unknown function (DUF3892)
MANCPEPA_02830 1.97e-119 batE - - T - - - Sh3 type 3 domain protein
MANCPEPA_02831 1.05e-202 rbsB - - G ko:K10439 ko02010,ko02030,map02010,map02030 ko00000,ko00001,ko00002,ko02000 COG1879 ABC-type sugar transport system, periplasmic component
MANCPEPA_02832 3.35e-203 rbsC - - G ko:K10440 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family
MANCPEPA_02833 0.0 rbsA 3.6.3.17 - G ko:K10441 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MANCPEPA_02834 3.24e-84 rbsD 5.4.99.62 - G ko:K06726 ko02010,map02010 ko00000,ko00001,ko01000 Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
MANCPEPA_02835 7.52e-206 rbsK 2.7.1.15 - H ko:K00852 ko00030,map00030 ko00000,ko00001,ko01000 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MANCPEPA_02836 2.68e-227 rbsR - - K ko:K02529 - ko00000,ko03000 transcriptional
MANCPEPA_02837 1.46e-283 capB - - M ko:K01932 - ko00000,ko01000 COG0769 UDP-N-acetylmuramyl tripeptide synthase
MANCPEPA_02838 8.44e-91 capC - - S ko:K22116 - ko00000 biosynthesis protein
MANCPEPA_02839 1.1e-276 capA - - M ko:K07282 - ko00000 enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
MANCPEPA_02840 2.29e-29 ywtC - - - - - - -
MANCPEPA_02841 1.37e-304 pgdS - - M - - - COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MANCPEPA_02842 4.69e-201 ywtE 3.1.3.104 - S ko:K21064 ko00740,ko01100,ko01110,map00740,map01100,map01110 ko00000,ko00001,ko00002,ko01000 hydrolases of the HAD superfamily
MANCPEPA_02843 1.42e-220 ywtF_2 - - K - - - Transcriptional regulator
MANCPEPA_02844 2.27e-315 ywtG - - U ko:K02100,ko:K06609,ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MANCPEPA_02845 1.95e-251 gerBC - - S ko:K06290,ko:K06293,ko:K06312 - ko00000 Spore germination protein
MANCPEPA_02846 3.4e-238 gerBB - - E ko:K06289,ko:K06292 - ko00000,ko02000 Spore germination protein
MANCPEPA_02847 3.12e-310 gerBA - - EG ko:K06291,ko:K06310 - ko00000 Spore germination protein
MANCPEPA_02848 9.14e-239 manA 5.3.1.8 - G ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 mannose-6-phosphate isomerase
MANCPEPA_02849 0.0 lytD 3.2.1.96 - G ko:K01227 ko00511,map00511 ko00000,ko00001,ko01000 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MANCPEPA_02850 8.52e-217 - - - - - - - -
MANCPEPA_02851 5.15e-49 - - - - - - - -
MANCPEPA_02852 4.43e-272 tagB 2.7.8.44 - M ko:K21285 - ko00000,ko01000 glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MANCPEPA_02853 1.9e-185 tagA 2.4.1.187 GT26 M ko:K05946 ko05111,map05111 ko00000,ko00001,ko01000,ko01003 Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
MANCPEPA_02854 3.82e-91 tagD 2.7.7.39 - IM ko:K00980 ko00564,map00564 ko00000,ko00001,ko01000 Cytidylyltransferase
MANCPEPA_02855 0.0 tagE 2.4.1.52 GT4 M ko:K00712 - ko00000,ko01000,ko01003 Glycosyl transferase 1 domain A
MANCPEPA_02856 0.0 tagF 2.7.8.12 - M ko:K09809 - ko00000,ko01000 glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MANCPEPA_02857 1.69e-193 tagG - - GM ko:K09692 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Transport permease protein
MANCPEPA_02858 0.0 tagH 3.6.3.40 - GM ko:K09693 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
MANCPEPA_02859 2.95e-207 gtaB 2.7.7.9 - M ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko00000,ko00001,ko00002,ko01000 UTP-glucose-1-phosphate uridylyltransferase
MANCPEPA_02860 1.01e-272 mnaA 5.1.3.14 - M ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 ko00000,ko00001,ko00002,ko01000,ko01005 Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MANCPEPA_02861 2.77e-219 lytR - - K - - - May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
MANCPEPA_02862 3.26e-50 - - - - - - - -
MANCPEPA_02863 0.0 lytB - - D - - - Stage II sporulation protein
MANCPEPA_02864 0.0 lytC 3.5.1.28 - M ko:K01448 ko01503,map01503 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 n-acetylmuramoyl-L-alanine amidase
MANCPEPA_02865 1.49e-143 tuaA - - M - - - COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MANCPEPA_02866 1.46e-315 tuaB - - S ko:K03328,ko:K16694,ko:K16695 - ko00000,ko02000 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_02867 9.41e-278 tuaC - GT4 GM ko:K16697 - ko00000,ko01000,ko01003 Teichuronic acid
MANCPEPA_02868 0.0 tuaD 1.1.1.22 - M ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MANCPEPA_02869 0.0 tuaE - - M ko:K16705 - ko00000 Teichuronic acid biosynthesis protein
MANCPEPA_02870 1.66e-146 tuaF - - M ko:K16706 - ko00000 protein involved in exopolysaccharide biosynthesis
MANCPEPA_02871 1.2e-186 tuaG - GT2 M ko:K16698 - ko00000,ko01000,ko01003 Glycosyltransferase like family 2
MANCPEPA_02872 4.13e-297 tuaH - - M ko:K16699 - ko00000,ko01000,ko01003 Teichuronic acid biosynthesis glycosyltransferase tuaH
MANCPEPA_02873 2.1e-231 tagO 2.7.8.33, 2.7.8.35 - M ko:K02851 - ko00000,ko01000,ko01003,ko01005 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
MANCPEPA_02874 6.6e-224 yvhJ - - K - - - Transcriptional regulator
MANCPEPA_02875 2.41e-155 yvyE 3.4.13.9 - S ko:K01271 - ko00000,ko01000,ko01002 Domain of unknown function (DUF1949)
MANCPEPA_02876 2.94e-247 degS 2.7.13.3 - T ko:K07777 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
MANCPEPA_02877 7.16e-163 degU - - KT ko:K02479,ko:K07692 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_02878 2.15e-199 degV - - S - - - protein conserved in bacteria
MANCPEPA_02879 0.0 comFA - - L ko:K02240 - ko00000,ko00002,ko02044 COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MANCPEPA_02880 1.04e-60 comFB - - S ko:K02241 - ko00000,ko00002,ko02044 Late competence development protein ComFB
MANCPEPA_02881 8.82e-160 comFC - - S ko:K02242 - ko00000,ko00002,ko02044 Phosphoribosyl transferase domain
MANCPEPA_02882 1.83e-96 yvyF - - S - - - flagellar protein
MANCPEPA_02883 1.06e-53 flgM - - KNU ko:K02398 ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 ko00000,ko00001,ko02035 Negative regulator of flagellin synthesis
MANCPEPA_02884 3.5e-102 yvyG - - NOU - - - FlgN protein
MANCPEPA_02885 0.0 flgK - - N ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 flagellar hook-associated protein
MANCPEPA_02886 3.8e-197 flgL - - N ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Belongs to the bacterial flagellin family
MANCPEPA_02887 1.7e-92 yviE - - - - - - -
MANCPEPA_02888 1.23e-96 fliW - - S ko:K13626 - ko00000,ko02035 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MANCPEPA_02889 1.23e-39 csrA - - T ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko00000,ko00001,ko03019 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MANCPEPA_02890 3.11e-143 hag - - N ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MANCPEPA_02891 3.03e-74 flaG - - N ko:K06603 - ko00000,ko02035 flagellar protein FlaG
MANCPEPA_02892 0.0 fliD - - N ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MANCPEPA_02893 2.1e-90 fliS - - N ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 flagellar protein FliS
MANCPEPA_02894 1.73e-08 fliT - - S ko:K02423 ko02040,map02040 ko00000,ko00001,ko02035 bacterial-type flagellum organization
MANCPEPA_02895 9.14e-88 - - - - - - - -
MANCPEPA_02896 1.73e-132 hpf - - J ko:K05808 - ko00000,ko03009 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MANCPEPA_02897 0.0 secA - - U ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MANCPEPA_02898 2e-232 prfB - - J ko:K02836 - ko00000,ko03012 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MANCPEPA_02899 1.86e-184 yvjA - - S - - - Uncharacterized protein conserved in bacteria (DUF2179)
MANCPEPA_02900 3.78e-74 cccB - - C ko:K12263,ko:K13300 - ko00000 COG2010 Cytochrome c, mono- and diheme variants
MANCPEPA_02901 1.5e-159 ftsE - - D ko:K09812 ko02010,map02010 ko00000,ko00001,ko00002,ko02000,ko03036 cell division ATP-binding protein FtsE
MANCPEPA_02902 1.1e-198 ftsX - - D ko:K09811 ko02010,map02010 ko00000,ko00001,ko00002,ko02000,ko03036 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
MANCPEPA_02903 0.0 ctpB 3.4.21.102 - M ko:K03797 - ko00000,ko01000,ko01002 Belongs to the peptidase S41A family
MANCPEPA_02904 1.38e-73 swrA - - S - - - Swarming motility protein
MANCPEPA_02905 3.17e-280 minJ - - O - - - COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANCPEPA_02906 5.24e-296 yvkA - - P - - - -transporter
MANCPEPA_02907 4.09e-131 yvkB - - K - - - Transcriptional regulator
MANCPEPA_02908 0.0 yvkC 2.7.9.2 - GT ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 ko00000,ko00001,ko00002,ko01000 Phosphotransferase
MANCPEPA_02909 2.54e-42 csbA - - S - - - protein conserved in bacteria
MANCPEPA_02910 0.0 uvrB - - L ko:K03702 ko03420,map03420 ko00000,ko00001,ko03400 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MANCPEPA_02911 0.0 uvrA - - L ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MANCPEPA_02912 4.93e-64 hag - - N ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MANCPEPA_02913 2.25e-45 yvkN - - - - - - -
MANCPEPA_02914 8.09e-65 yvlA - - - - - - -
MANCPEPA_02915 9.59e-220 yvlB - - S - - - Putative adhesin
MANCPEPA_02916 1.5e-36 yvlC - - KT ko:K03973 - ko00000,ko02048,ko03000 PspC domain
MANCPEPA_02917 3.8e-66 yvlD - - S ko:K08972 - ko00000 Membrane
MANCPEPA_02918 0.0 yvnB - - Q - - - Calcineurin-like phosphoesterase
MANCPEPA_02919 3.02e-171 yvoA - - K ko:K03710 - ko00000,ko03000 transcriptional
MANCPEPA_02920 4.1e-164 nagB 3.5.99.6 - G ko:K02564 ko00520,ko01100,map00520,map01100 ko00000,ko00001,ko01000 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MANCPEPA_02921 8.05e-278 nagA 3.5.1.25 - G ko:K01443 ko00520,ko01130,map00520,map01130 ko00000,ko00001,ko01000 Belongs to the metallo-dependent hydrolases superfamily. NagA family
MANCPEPA_02922 3.62e-217 hprK - - F ko:K06023 - ko00000,ko01000 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MANCPEPA_02923 4.33e-193 lgt - - M ko:K13292 - ko00000,ko01000 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MANCPEPA_02924 3.56e-209 yvoD - - P - - - COG0370 Fe2 transport system protein B
MANCPEPA_02925 3.05e-153 ppaX 3.6.1.1 - S ko:K06019 ko00190,map00190 ko00000,ko00001,ko01000 Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
MANCPEPA_02926 5.94e-118 yvoF 2.3.1.79 - S ko:K00661 - ko00000,ko01000 COG0110 Acetyltransferase (isoleucine patch superfamily)
MANCPEPA_02927 1.1e-153 - 4.2.2.10, 4.2.2.2 - G ko:K19551 ko00040,map00040 ko00000,ko00001,ko01000 Pectate lyase
MANCPEPA_02928 5.03e-178 yvpB - - NU - - - protein conserved in bacteria
MANCPEPA_02929 2.42e-281 hisZ - - E ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MANCPEPA_02930 1.06e-147 hisG 2.4.2.17 - E ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MANCPEPA_02931 3e-291 hisD 1.1.1.23 - E ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MANCPEPA_02932 2.02e-138 hisB 4.2.1.19 - E ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 imidazoleglycerol-phosphate dehydratase
MANCPEPA_02933 1.15e-146 hisH - - E ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MANCPEPA_02934 5.38e-166 hisA 5.3.1.16 - E ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MANCPEPA_02935 5.63e-176 hisF - - E ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MANCPEPA_02936 2.61e-146 hisI 3.5.4.19, 3.6.1.31 - E ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 belongs to the PRA-CH family
MANCPEPA_02937 6.36e-172 - - - - - - - -
MANCPEPA_02938 0.0 - - - - - - - -
MANCPEPA_02940 0.0 lmrA 3.6.3.44 - V ko:K02021,ko:K18104 ko01501,ko02010,map01501,map02010 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 ABC transporter
MANCPEPA_02941 0.0 yvcD - - S - - - COG0457 FOG TPR repeat
MANCPEPA_02942 3.79e-185 spl - - M ko:K21471 - ko00000,ko01000,ko01002,ko01011 protein conserved in bacteria
MANCPEPA_02943 1.18e-225 trxB 1.8.1.9 - C ko:K00384 ko00450,map00450 ko00000,ko00001,ko01000 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MANCPEPA_02944 5.65e-116 yvcI 3.6.1.55 - F ko:K03574 - ko00000,ko01000,ko03400 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MANCPEPA_02945 2.09e-213 yvcJ - - S ko:K06958 - ko00000,ko03019 Displays ATPase and GTPase activities
MANCPEPA_02946 6.72e-227 yvcK - - S - - - Required for morphogenesis under gluconeogenic growth conditions
MANCPEPA_02947 3.63e-220 whiA - - K ko:K09762 - ko00000 May be required for sporulation
MANCPEPA_02948 3.92e-50 crh - - G ko:K11184 - ko00000 Phosphocarrier protein Chr
MANCPEPA_02949 2.39e-184 yvcN 2.3.1.118 - Q ko:K00675 - ko00000,ko01000 Belongs to the arylamine N-acetyltransferase family
MANCPEPA_02950 3.84e-171 yvcP - - T ko:K02483,ko:K11634 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_02951 7.97e-251 yvcQ - - T - - - His Kinase A (phosphoacceptor) domain
MANCPEPA_02952 2.58e-180 yxdL_2 - - V ko:K02003,ko:K11635 ko02020,map02020 ko00000,ko00001,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_02953 0.0 - - - V ko:K02004 - ko00000,ko00002,ko02000 ABC transporter (permease)
MANCPEPA_02954 1.9e-233 yvcT 1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81 - CH ko:K00015,ko:K00090 ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120 ko00000,ko00001,ko01000 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MANCPEPA_02955 1.25e-135 yvdA 4.2.1.1 - P ko:K01673 ko00910,map00910 ko00000,ko00001,ko01000 Reversible hydration of carbon dioxide
MANCPEPA_02956 0.0 yvdB - - P ko:K03321 - ko00000,ko02000 COG0659 Sulfate permease and related transporters (MFS superfamily)
MANCPEPA_02957 4.54e-70 yvdC - - S - - - MazG nucleotide pyrophosphohydrolase domain
MANCPEPA_02958 5.37e-137 yvdD 3.2.2.10 - S ko:K06966 ko00230,ko00240,map00230,map00240 ko00000,ko00001,ko01000 Belongs to the LOG family
MANCPEPA_02959 1.32e-222 yvdE - - K - - - Transcriptional regulator
MANCPEPA_02960 0.0 nplT 3.2.1.133, 3.2.1.135, 3.2.1.54 GH13 G ko:K01208 ko00500,ko01100,map00500,map01100 ko00000,ko00001,ko01000 Alpha amylase, N-terminal ig-like domain
MANCPEPA_02961 3.44e-301 mdxE - - G ko:K02027,ko:K15770,ko:K17237 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG2182 Maltose-binding periplasmic proteins domains
MANCPEPA_02962 5.83e-309 malC - - P ko:K15771 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1175 ABC-type sugar transport systems, permease components
MANCPEPA_02963 2.79e-189 malD - - P ko:K15772 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 transport
MANCPEPA_02964 9.74e-198 malA - - S - - - Protein of unknown function (DUF1189)
MANCPEPA_02965 0.0 yvdK 2.4.1.8 GH65 G ko:K00691 ko00500,ko01100,map00500,map01100 ko00000,ko00001,ko01000 Glycoside hydrolase, family 65
MANCPEPA_02966 0.0 malL 3.2.1.10 GH13 G ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 ko00000,ko00001,ko01000 COG0366 Glycosidases
MANCPEPA_02967 1.22e-152 pgmB 5.4.2.6 - S ko:K01838 ko00500,map00500 ko00000,ko00001,ko01000 Haloacid dehalogenase-like hydrolase
MANCPEPA_02968 8.17e-135 clpP 3.4.21.92 - OU ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MANCPEPA_02972 3.45e-47 - - - - - - - -
MANCPEPA_02973 6.03e-113 sdpB - - S - - - Vitamin K-dependent gamma-carboxylase
MANCPEPA_02974 3.08e-95 - - - V - - - Beta-lactamase enzyme family
MANCPEPA_02975 1.57e-232 - - - S - - - Patatin-like phospholipase
MANCPEPA_02976 0.0 yvdP - - C - - - COG0277 FAD FMN-containing dehydrogenases
MANCPEPA_02977 5.53e-122 yvdQ - - S - - - Protein of unknown function (DUF3231)
MANCPEPA_02978 1.03e-66 yvdR - - P ko:K11741 - ko00000,ko02000 Small Multidrug Resistance protein
MANCPEPA_02979 3e-66 yvdS - - P ko:K18924 - ko00000,ko00002,ko02000 Small Multidrug Resistance protein
MANCPEPA_02980 1.17e-137 yvdT_1 - - K - - - Transcriptional regulator
MANCPEPA_02981 0.0 ybeC - - E - - - amino acid
MANCPEPA_02982 0.0 sacC3 3.2.1.65 GH32 G ko:K01212 ko00500,map00500 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 32 family
MANCPEPA_02983 0.0 sacB 2.4.1.10, 2.4.1.9 GH68 M ko:K00692,ko:K20811 ko00500,ko01100,ko02020,map00500,map01100,map02020 ko00000,ko00001,ko01000,ko01003 levansucrase activity
MANCPEPA_02984 1.85e-70 pbpE - - V - - - Beta-lactamase
MANCPEPA_02985 2.06e-161 racX 5.1.1.13 - M ko:K01779 ko00250,ko01054,map00250,map01054 ko00000,ko00001,ko01000 Belongs to the aspartate glutamate racemases family
MANCPEPA_02986 1.23e-93 - - - S - - - Protein of unknown function (DUF3237)
MANCPEPA_02987 5.4e-120 padC - - Q ko:K13727 - ko00000,ko01000 Phenolic acid decarboxylase
MANCPEPA_02989 6.66e-171 pnbA - CE10 I ko:K03929 - ko00000,ko01000 Belongs to the type-B carboxylesterase lipase family
MANCPEPA_02990 4.96e-165 pnbA - CE10 I ko:K03929 - ko00000,ko01000 Belongs to the type-B carboxylesterase lipase family
MANCPEPA_02991 3.57e-98 - - - K ko:K19417 - ko00000,ko03000 transcriptional
MANCPEPA_02992 2.78e-158 epsA - - M ko:K19420 - ko00000 biosynthesis protein
MANCPEPA_02993 7.94e-150 ywqD 2.7.10.2 - D ko:K00903 - ko00000,ko01000,ko01001 COG0489 ATPases involved in chromosome partitioning
MANCPEPA_02994 0.0 capD - - GM ko:K19421 - ko00000 Polysaccharide biosynthesis protein
MANCPEPA_02995 9.46e-283 epsD - GT4 M ko:K19422 - ko00000,ko01000 Glycosyl transferase 4-like
MANCPEPA_02996 8.8e-202 epsE - GT2 M ko:K19423 - ko00000,ko01000,ko01003 COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_02997 5.65e-275 epsF - GT4 M ko:K19424 - ko00000,ko01000,ko01003 Glycosyl transferases group 1
MANCPEPA_02998 3.59e-264 epsG - - S ko:K19419 - ko00000,ko02000 EpsG family
MANCPEPA_02999 1e-247 epsH - GT2 S ko:K19425 - ko00000,ko01000,ko01003 Glycosyltransferase like family 2
MANCPEPA_03000 9.86e-262 epsI - - GM ko:K19426 - ko00000,ko01000 pyruvyl transferase
MANCPEPA_03001 1.03e-240 epsJ - GT2 S ko:K19427 - ko00000,ko01000 COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_03002 0.0 epsK - - S ko:K19418 - ko00000,ko02000 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_03003 3.19e-139 epsL - - M ko:K13012,ko:K19428 - ko00000,ko01000,ko01005 COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MANCPEPA_03004 1.17e-76 epsM - - GM ko:K19429 - ko00000,ko01000 COG0110 Acetyltransferase (isoleucine patch superfamily)
MANCPEPA_03005 7.78e-281 epsN - - E ko:K19430 - ko00000,ko01000 Belongs to the DegT DnrJ EryC1 family
MANCPEPA_03006 2.95e-238 epsO - - GM ko:K19431 - ko00000,ko01000 Exopolysaccharide biosynthesis protein
MANCPEPA_03007 5.69e-44 yvfG - - S - - - YvfG protein
MANCPEPA_03008 9.59e-304 rpoN - - K ko:K03092 ko02020,ko05111,map02020,map05111 ko00000,ko00001,ko03021 COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
MANCPEPA_03009 0.0 lctP - - C ko:K03303 - ko00000,ko02000 L-lactate permease
MANCPEPA_03010 1.18e-146 yvfI - - K ko:K05799 - ko00000,ko03000 COG2186 Transcriptional regulators
MANCPEPA_03011 6.42e-237 lacR - - K ko:K02529 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_03012 8.35e-295 cycB - - G ko:K02027,ko:K15770,ko:K17237 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG2182 Maltose-binding periplasmic proteins domains
MANCPEPA_03013 1.24e-299 malC - - P ko:K15771 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1175 ABC-type sugar transport systems, permease components
MANCPEPA_03014 1.1e-193 malG - - P ko:K15772 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 transport
MANCPEPA_03015 0.0 lacA 3.2.1.23 - G ko:K12308 ko00052,map00052 ko00000,ko00001,ko01000 beta-galactosidase
MANCPEPA_03016 0.0 ganB 3.2.1.89 - G ko:K01224 - ko00000,ko01000 arabinogalactan
MANCPEPA_03017 1.77e-264 - 3.1.3.3 - T ko:K07315 - ko00000,ko01000,ko03021 response regulator
MANCPEPA_03018 4.2e-200 rsbQ - - S ko:K19707 - ko00000,ko03021 Alpha/beta hydrolase family
MANCPEPA_03019 1.57e-204 yvfR - - V ko:K01990 - ko00000,ko00002,ko02000 COG1131 ABC-type multidrug transport system, ATPase component
MANCPEPA_03020 5.01e-171 XK27_09830 - - V ko:K01992 - ko00000,ko00002,ko02000 COG0842 ABC-type multidrug transport system, permease component
MANCPEPA_03021 4.24e-249 yvfT 2.7.13.3 - T ko:K07778 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03022 4.36e-136 desR - - T ko:K02479,ko:K07693 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_03023 3.17e-175 lutA - - C ko:K18928 - ko00000 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MANCPEPA_03024 0.0 lutB - - C ko:K18929 - ko00000 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
MANCPEPA_03025 2.4e-171 lutC - - S ko:K00782 - ko00000 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MANCPEPA_03026 6.04e-249 - - - S - - - Glycosyl hydrolase
MANCPEPA_03027 1.37e-304 yvbW - - E ko:K03293 - ko00000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_03028 1.13e-197 yvbV - - EG - - - EamA-like transporter family
MANCPEPA_03029 4.9e-206 yvbU - - K - - - Transcriptional regulator
MANCPEPA_03030 1.04e-245 yvbT - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_03031 1.51e-258 araR - - K ko:K02103 - ko00000,ko03000 transcriptional
MANCPEPA_03032 0.0 araE - - U ko:K02100,ko:K06609,ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MANCPEPA_03033 9.84e-237 cggR - - K ko:K05311 - ko00000,ko03000 COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MANCPEPA_03034 5.72e-238 gapA 1.2.1.12 - G ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MANCPEPA_03035 3.27e-276 pgk 2.7.2.3 - F ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the phosphoglycerate kinase family
MANCPEPA_03036 2.12e-176 tpiA 5.3.1.1 - G ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000,ko04147 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MANCPEPA_03037 0.0 gpmI 5.4.2.12 - G ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the interconversion of 2-phosphoglycerate and
MANCPEPA_03038 1.38e-309 eno 4.2.1.11 - G ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MANCPEPA_03039 3.01e-209 ywaD 3.4.11.10, 3.4.11.6 - S ko:K19701 - ko00000,ko01000,ko01002 PA domain
MANCPEPA_03040 9.13e-274 - 1.1.1.136 - M ko:K13015 ko00520,map00520 ko00000,ko00001,ko01000,ko01005 UDP binding domain
MANCPEPA_03041 1.86e-234 - 2.6.1.102 - E ko:K13010 ko00520,map00520 ko00000,ko00001,ko01000,ko01005,ko01007 Belongs to the DegT DnrJ EryC1 family
MANCPEPA_03042 1.49e-188 arnA 4.2.1.46, 5.1.3.2 - M ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 ko00000,ko00001,ko00002,ko01000 GDP-mannose 4,6 dehydratase
MANCPEPA_03043 2.83e-197 - - - E - - - UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MANCPEPA_03044 2.55e-144 - - - M - - - Protein involved in cellulose biosynthesis
MANCPEPA_03045 4.1e-157 - - - C - - - WbqC-like protein family
MANCPEPA_03046 3.24e-148 - - - S - - - GlcNAc-PI de-N-acetylase
MANCPEPA_03047 2.52e-192 - - - - - - - -
MANCPEPA_03048 3.28e-220 - - - EGP - - - Major facilitator Superfamily
MANCPEPA_03049 2.8e-105 yvbK - - K - - - acetyltransferase
MANCPEPA_03050 0.0 tcaA - - S ko:K21463 - ko00000 response to antibiotic
MANCPEPA_03051 1.13e-156 yvbI - - M - - - Membrane
MANCPEPA_03052 2.96e-145 yvbH - - S - - - YvbH-like oligomerisation region
MANCPEPA_03053 7.95e-135 yvbG - - U ko:K05595 - ko00000,ko02000 UPF0056 membrane protein
MANCPEPA_03054 8.29e-129 yvbF - - K ko:K22301 - ko00000,ko03000 Belongs to the GbsR family
MANCPEPA_03055 5.58e-270 opuCA - - E ko:K05847 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MANCPEPA_03056 4.63e-144 opuCB - - P ko:K05846 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1174 ABC-type proline glycine betaine transport systems, permease component
MANCPEPA_03057 4.11e-220 opuCC - - M ko:K05845 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MANCPEPA_03058 9.67e-137 opuCD - - P ko:K05846 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1174 ABC-type proline glycine betaine transport systems, permease component
MANCPEPA_03059 6.63e-122 yvbF - - K ko:K22301 - ko00000,ko03000 Belongs to the GbsR family
MANCPEPA_03060 4.75e-267 opuCA - - E ko:K05847 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MANCPEPA_03061 1.55e-142 opuCB - - P ko:K05846 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1174 ABC-type proline glycine betaine transport systems, permease component
MANCPEPA_03062 3.33e-215 opuCC - - M ko:K05845 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MANCPEPA_03063 1.25e-141 opuCD - - P ko:K05846 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1174 ABC-type proline glycine betaine transport systems, permease component
MANCPEPA_03064 0.0 yvaQ - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_03065 3.85e-72 yvaP - - K - - - transcriptional
MANCPEPA_03066 9.82e-92 yvaO - - K ko:K22299 - ko00000,ko03000 Cro/C1-type HTH DNA-binding domain
MANCPEPA_03067 4.08e-92 yvaO - - K ko:K22299 - ko00000,ko03000 transcriptional
MANCPEPA_03068 3.44e-48 yvzC - - K - - - transcriptional
MANCPEPA_03069 2.73e-192 yvaM 1.11.1.10 - S ko:K00433 - ko00000,ko01000 Serine aminopeptidase, S33
MANCPEPA_03070 1.87e-35 secG - - U ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Preprotein translocase subunit SecG
MANCPEPA_03071 3.43e-183 est 3.1.1.1 - S ko:K03928 - ko00000,ko01000 Carboxylesterase
MANCPEPA_03072 0.0 rnr - - K ko:K12573 ko03018,map03018 ko00000,ko00001,ko01000,ko03016,ko03019 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MANCPEPA_03073 2.4e-107 smpB - - O ko:K03664 - ko00000 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MANCPEPA_03075 3.96e-182 yvaG 1.1.1.100 - IQ ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03076 1.17e-126 - - - K - - - Bacterial regulatory proteins, tetR family
MANCPEPA_03077 3.52e-71 yvaE - - P ko:K03297 - ko00000,ko02000 Small Multidrug Resistance protein
MANCPEPA_03078 2.02e-97 yvaD - - S - - - Family of unknown function (DUF5360)
MANCPEPA_03079 0.0 - - - S - - - Fusaric acid resistance protein-like
MANCPEPA_03080 2.08e-153 azoR - - I ko:K01118 - ko00000,ko01000 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MANCPEPA_03081 1.71e-248 yvaA 1.1.1.371 - S ko:K16044 ko00562,ko01120,map00562,map01120 ko00000,ko00001,ko01000 Oxidoreductase
MANCPEPA_03082 6.89e-65 csoR - - S ko:K21600 - ko00000,ko03000 transcriptional
MANCPEPA_03083 3.02e-40 copZ - - P ko:K07213 ko04978,map04978 ko00000,ko00001 Copper resistance protein CopZ
MANCPEPA_03084 0.0 copA 3.6.3.54 - P ko:K17686 ko01524,ko04016,map01524,map04016 ko00000,ko00001,ko01000 P-type ATPase
MANCPEPA_03085 0.0 cadA 3.6.3.3, 3.6.3.5 - P ko:K01534 - ko00000,ko01000 COG2217 Cation transport ATPase
MANCPEPA_03086 3.45e-137 bdbD - - O - - - Thioredoxin
MANCPEPA_03087 1.99e-95 bdbC - - O ko:K03611 - ko00000,ko03110 Required for disulfide bond formation in some proteins
MANCPEPA_03088 3.88e-140 yvgT - - S - - - membrane
MANCPEPA_03089 0.0 helD 3.6.4.12 - L ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 DNA helicase
MANCPEPA_03090 0.0 cysJ 1.8.1.2 - P ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MANCPEPA_03091 0.0 cysI 1.8.1.2, 1.8.7.1 - P ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
MANCPEPA_03092 0.0 yvgP - - P ko:K03316 - ko00000 COG0025 NhaP-type Na H and K H antiporters
MANCPEPA_03093 7.97e-113 yvgO - - - - - - -
MANCPEPA_03094 6.19e-201 yvgN - - S - - - reductase
MANCPEPA_03095 1.43e-152 modB - - P ko:K02018 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG4149 ABC-type molybdate transport system, permease component
MANCPEPA_03096 2.11e-175 modA - - P ko:K02020 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0725 ABC-type molybdate transport system, periplasmic component
MANCPEPA_03097 4.21e-213 yvgK - - P ko:K07219 - ko00000 COG1910 Periplasmic molybdate-binding protein domain
MANCPEPA_03098 0.0 yvgJ - - M ko:K01138 - ko00000,ko01000 Belongs to the LTA synthase family
MANCPEPA_03099 2.38e-109 yvsG - - S ko:K07038 - ko00000 LexA-binding, inner membrane-associated putative hydrolase
MANCPEPA_03100 9.37e-23 - - - S ko:K06427 - ko00000 Small spore protein J (Spore_SspJ)
MANCPEPA_03101 0.0 yvsH - - E ko:K03294,ko:K03758 - ko00000,ko02000 Arginine ornithine antiporter
MANCPEPA_03102 1.09e-225 fhuD - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter
MANCPEPA_03103 3.47e-236 fhuB - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03104 9.64e-226 fhuG - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03105 9.78e-190 fhuC 3.6.3.34 - HP ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter
MANCPEPA_03106 6.94e-229 - - - M ko:K02005 - ko00000 Efflux transporter rnd family, mfp subunit
MANCPEPA_03107 4.64e-159 yvrO - - V ko:K02003 - ko00000,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_03108 2.21e-272 yvrN - - V ko:K02004 - ko00000,ko00002,ko02000 COG0577 ABC-type antimicrobial peptide transport system, permease component
MANCPEPA_03109 1.64e-84 yvrL - - S - - - Regulatory protein YrvL
MANCPEPA_03110 1.08e-290 oxdC 4.1.1.2 - G ko:K01569 ko00630,ko01100,map00630,map01100 ko00000,ko00001,ko01000 Oxalate decarboxylase
MANCPEPA_03111 3.46e-26 - - - S - - - YvrJ protein family
MANCPEPA_03112 4.06e-127 yvrI - - K ko:K03093 - ko00000,ko03021 RNA polymerase
MANCPEPA_03113 5.07e-32 - - - - - - - -
MANCPEPA_03114 2.08e-169 yvrH - - T ko:K02483 - ko00000,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_03115 0.0 yvrG - - T - - - Histidine kinase
MANCPEPA_03116 1.32e-219 yvrE - - G ko:K14274 ko00040,map00040 ko00000,ko00001,ko01000 SMP-30/Gluconolaconase/LRE-like region
MANCPEPA_03117 2.12e-181 yvrD - - IQ - - - Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03118 3.48e-217 btuF - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component
MANCPEPA_03119 6.35e-235 btuC - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03120 3.76e-316 yvrA 3.6.3.34 - HP ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
MANCPEPA_03121 8.21e-133 yvqK 2.5.1.17 - S ko:K00798 ko00860,ko01100,map00860,map01100 ko00000,ko00001,ko00002,ko01000 Adenosyltransferase
MANCPEPA_03122 1.13e-288 yvqJ - - EGP - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03123 1.51e-82 liaI - - S ko:K11619 ko02020,map02020 ko00000,ko00001,ko00002 membrane
MANCPEPA_03124 9.94e-143 liaH - - KT ko:K03969,ko:K11620 ko02020,map02020 ko00000,ko00001,ko00002 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
MANCPEPA_03125 1.41e-172 liaG - - S ko:K11621 ko02020,map02020 ko00000,ko00001 Putative adhesin
MANCPEPA_03126 1.27e-162 - - - S ko:K11622 ko02020,map02020 ko00000,ko00001 Cell wall-active antibiotics response 4TMS YvqF
MANCPEPA_03127 4.06e-246 vraS 2.7.13.3 - T ko:K07681,ko:K11617 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03128 9.39e-141 vraR - - KT ko:K07694,ko:K11618 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_03129 3.48e-249 gerAC - - S ko:K06290,ko:K06293,ko:K06312 - ko00000 Spore germination B3/ GerAC like, C-terminal
MANCPEPA_03130 2.9e-253 gerAB - - E ko:K06289,ko:K06292 - ko00000,ko02000 Spore germination protein
MANCPEPA_03131 0.0 gerAA - - EG ko:K06288,ko:K06291,ko:K06310 - ko00000 Spore germination protein
MANCPEPA_03132 1.06e-32 - - - S - - - Protein of unknown function (DUF3970)
MANCPEPA_03133 0.0 fumC 4.2.1.2 - C ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 ko00000,ko00001,ko00002,ko01000 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MANCPEPA_03134 3.06e-204 yuxN - - K - - - Transcriptional regulator
MANCPEPA_03135 0.0 cssS 2.7.13.3 - T ko:K07650 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03136 2.23e-164 cssR - - T ko:K07770 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_03137 9.21e-304 htrA 3.4.21.107 - O ko:K04771 ko01503,ko02020,map01503,map02020 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANCPEPA_03138 1.07e-104 fri - - P ko:K04047 - ko00000,ko03036 Ferritin-like domain
MANCPEPA_03139 5.47e-197 yusZ - - IQ - - - Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03140 0.0 pepF2 - - E - - - COG1164 Oligoendopeptidase F
MANCPEPA_03141 3.48e-88 - - - S - - - YusW-like protein
MANCPEPA_03142 8.74e-196 yusV 3.6.3.34 - HP ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter
MANCPEPA_03143 3.66e-64 yusU - - S - - - Protein of unknown function (DUF2573)
MANCPEPA_03144 8.42e-204 gltR - - K ko:K21959 - ko00000,ko03000 LysR substrate binding domain
MANCPEPA_03145 4.97e-138 yusR 1.1.1.100 - IQ ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03146 3.42e-84 yusQ - - S - - - Tautomerase enzyme
MANCPEPA_03147 0.0 yusP - - P - - - Major facilitator superfamily
MANCPEPA_03148 4.47e-98 yusO - - K - - - Iron dependent repressor, N-terminal DNA binding domain
MANCPEPA_03149 2.04e-68 yusN - - M - - - Coat F domain
MANCPEPA_03150 2.23e-54 - - - - - - - -
MANCPEPA_03151 2.84e-210 fadM - - E ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 ko00000,ko00001,ko01000 Proline dehydrogenase
MANCPEPA_03152 1.11e-13 - - - S - - - YuzL-like protein
MANCPEPA_03153 0.0 fadN 1.1.1.35 - I ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 ko00000,ko00001,ko00002,ko01000 3-hydroxyacyl-CoA dehydrogenase
MANCPEPA_03154 1.34e-278 fadA 2.3.1.16 - I ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 ko00000,ko00001,ko00002,ko01000 Belongs to the thiolase family
MANCPEPA_03155 0.0 fadE 1.3.8.1 - I ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 ko00000,ko00001,ko01000 acyl-CoA dehydrogenase
MANCPEPA_03156 1.01e-83 yusI 1.20.4.1 - P ko:K00537 - ko00000,ko01000 Belongs to the ArsC family
MANCPEPA_03157 5.91e-85 gcvH - - E ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko00000,ko00001,ko00002 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
MANCPEPA_03158 7.34e-54 yusG - - S - - - Protein of unknown function (DUF2553)
MANCPEPA_03159 7.62e-97 yusF - - L ko:K07476 - ko00000 COG1658 Small primase-like proteins (Toprim domain)
MANCPEPA_03160 5.73e-73 yusE - - CO - - - Thioredoxin
MANCPEPA_03161 1.53e-74 yusD - - S - - - SCP-2 sterol transfer family
MANCPEPA_03162 2.15e-236 metN - - P ko:K02071 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MANCPEPA_03163 2.64e-125 metI - - P ko:K02069,ko:K02072 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG2011 ABC-type metal ion transport system, permease component
MANCPEPA_03164 2.91e-189 metQ - - P ko:K02072,ko:K02073 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the NlpA lipoprotein family
MANCPEPA_03165 5.44e-81 yurZ - - S - - - Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MANCPEPA_03166 3.82e-183 sufC - - O ko:K09013 - ko00000,ko02000 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
MANCPEPA_03167 7.43e-313 sufD - - O ko:K07033,ko:K09015 - ko00000 assembly protein SufD
MANCPEPA_03168 3.99e-299 sufS 2.8.1.7, 4.4.1.16 - E ko:K11717 ko00450,ko01100,map00450,map01100 ko00000,ko00001,ko01000 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MANCPEPA_03169 6.26e-101 nifU - - C ko:K04488 - ko00000 COG0822 NifU homolog involved in Fe-S cluster formation
MANCPEPA_03170 0.0 sufB - - O ko:K07033,ko:K09014 - ko00000 FeS cluster assembly
MANCPEPA_03171 3.35e-56 - - - - - - - -
MANCPEPA_03173 9.18e-265 yurR 1.4.5.1 - E ko:K00285 ko00360,map00360 ko00000,ko00001,ko01000 COG0665 Glycine D-amino acid oxidases (deaminating)
MANCPEPA_03174 1.2e-87 yurQ - - L - - - COG0322 Nuclease subunit of the excinuclease complex
MANCPEPA_03175 1.29e-235 frlB - - M ko:K10708 - ko00000,ko01000 Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
MANCPEPA_03176 1.17e-306 yurO - - G ko:K10117 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG1653 ABC-type sugar transport system, periplasmic component
MANCPEPA_03177 3.54e-199 yurN - - G ko:K10118 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_03178 4.58e-215 - - - P ko:K10119 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0395 ABC-type sugar transport system, permease component
MANCPEPA_03179 6.2e-205 - 2.7.1.218 - G ko:K10710 - ko00000,ko01000 pfkB family carbohydrate kinase
MANCPEPA_03180 5.04e-174 frlR1 - - K ko:K03710,ko:K10711 - ko00000,ko03000 UTRA
MANCPEPA_03181 2.42e-262 msmX - - P ko:K10112 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_03182 3.9e-210 bsn - - L - - - Ribonuclease
MANCPEPA_03183 1.64e-301 pucF 3.5.3.9 - E ko:K02083 ko00230,ko01120,map00230,map01120 ko00000,ko00001,ko01000,ko01002 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MANCPEPA_03184 8.51e-306 pucG 2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51 - E ko:K00830,ko:K00839 ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 ko00000,ko00001,ko00002,ko01000,ko01007 COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
MANCPEPA_03186 3.87e-238 pucA 1.17.1.4 - O ko:K00087,ko:K07402 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MANCPEPA_03187 4.18e-141 pucB 1.17.1.4, 2.7.7.76 - S ko:K00087,ko:K07141 ko00230,ko00790,ko01100,ko01120,map00230,map00790,map01100,map01120 ko00000,ko00001,ko00002,ko01000 MobA-like NTP transferase domain
MANCPEPA_03188 2.76e-184 pucC 1.17.1.4, 1.2.5.3 - C ko:K00087,ko:K03519 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
MANCPEPA_03189 0.0 pucD 1.17.1.4 - C ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
MANCPEPA_03190 6.95e-122 - 1.17.1.4, 1.2.5.3 - C ko:K00087,ko:K03518 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
MANCPEPA_03191 1.47e-72 pucM 3.5.2.17 - S ko:K07127 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000,ko02000 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
MANCPEPA_03192 0.0 - 1.7.3.3, 4.1.1.97 - Q ko:K16838 ko00230,ko00232,ko01100,ko01120,map00230,map00232,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin
MANCPEPA_03193 4.52e-283 pbuX - - F ko:K16169,ko:K16170 - ko00000,ko02000 xanthine
MANCPEPA_03194 3.44e-299 pbuX - - F ko:K03458,ko:K16169,ko:K16170 - ko00000,ko02000 Permease family
MANCPEPA_03195 0.0 pucR - - QT ko:K09684 - ko00000,ko03000 COG2508 Regulator of polyketide synthase expression
MANCPEPA_03196 0.0 allB 3.5.2.5 - F ko:K01466 ko00230,ko01100,ko01120,map00230,map01100,map01120 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
MANCPEPA_03197 1.07e-79 yunG - - - - - - -
MANCPEPA_03198 4.26e-220 yunF - - S - - - Protein of unknown function DUF72
MANCPEPA_03199 6.51e-181 yunE - - S ko:K07090 - ko00000 membrane transporter protein
MANCPEPA_03200 0.0 yunD 3.1.3.5 - F ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the 5'-nucleotidase family
MANCPEPA_03201 8.06e-64 yunC - - S - - - Domain of unknown function (DUF1805)
MANCPEPA_03202 2.46e-171 yunB - - S - - - Sporulation protein YunB (Spo_YunB)
MANCPEPA_03203 2.66e-252 lytH - - M ko:K21472 - ko00000,ko01000,ko01002,ko01011 Peptidase, M23
MANCPEPA_03204 1.37e-215 lipA 2.8.1.8 - H ko:K03644 ko00785,ko01100,map00785,map01100 ko00000,ko00001,ko01000 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MANCPEPA_03205 2.71e-144 yutC - - S - - - Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MANCPEPA_03206 3.2e-63 yutD - - S - - - protein conserved in bacteria
MANCPEPA_03207 2.38e-99 yutE - - S - - - Protein of unknown function DUF86
MANCPEPA_03208 3.69e-183 nagD 3.1.3.41 - G ko:K01101 ko00627,ko01120,map00627,map01120 ko00000,ko00001,ko01000 Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MANCPEPA_03209 2.26e-101 yutG 3.1.3.27 - I ko:K01095 ko00564,ko01100,map00564,map01100 ko00000,ko00001,ko01000 COG1267 Phosphatidylglycerophosphatase A and related proteins
MANCPEPA_03210 4.45e-253 yutH - - S - - - Spore coat protein
MANCPEPA_03211 1.67e-307 hom 1.1.1.3 - E ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko00002,ko01000 homoserine dehydrogenase
MANCPEPA_03212 2.4e-253 thrC 4.2.3.1 - E ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MANCPEPA_03213 1.04e-220 thrB 2.7.1.39 - E ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MANCPEPA_03214 0.0 yuxL 3.4.19.1 - EU ko:K01303 - ko00000,ko01000,ko01002 peptidase
MANCPEPA_03215 1.26e-47 yutI - - O - - - COG0694 Thioredoxin-like proteins and domains
MANCPEPA_03216 6.61e-75 yuzD - - S - - - protein conserved in bacteria
MANCPEPA_03217 1.12e-253 yutJ 1.6.99.3 - C ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 NADH dehydrogenase
MANCPEPA_03218 1.74e-52 yuzB - - S - - - Belongs to the UPF0349 family
MANCPEPA_03219 6.25e-270 yutK - - F ko:K03317 - ko00000 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MANCPEPA_03220 3.9e-208 dapF 5.1.1.7 - E ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 ko00000,ko00001,ko00002,ko01000 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MANCPEPA_03221 6.81e-83 erpA - - S ko:K13628 - ko00000,ko03016 Belongs to the HesB IscA family
MANCPEPA_03222 1.39e-115 paiA 2.3.1.57 - K ko:K22441 - ko00000,ko01000 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_03223 5.51e-147 paiB - - K ko:K07734 - ko00000,ko03000 Putative FMN-binding domain
MANCPEPA_03224 6.4e-235 guaC 1.7.1.7 - F ko:K00364 ko00230,map00230 ko00000,ko00001,ko01000 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MANCPEPA_03226 1.92e-239 yumC 1.18.1.2, 1.19.1.1 - C ko:K21567 - ko00000,ko01000 reductase
MANCPEPA_03227 4.16e-301 yumB 1.6.99.3 - C ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 NADH dehydrogenase
MANCPEPA_03228 1.14e-45 yuiB - - S - - - Putative membrane protein
MANCPEPA_03229 3.14e-149 yuiC - - S - - - protein conserved in bacteria
MANCPEPA_03230 8.63e-102 yuiD - - S ko:K09775 - ko00000 protein conserved in bacteria
MANCPEPA_03231 0.0 pepA 3.4.11.1 - E ko:K01255 ko00480,ko01100,map00480,map01100 ko00000,ko00001,ko01000,ko01002 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MANCPEPA_03232 3.65e-279 yuiF - - S ko:K07084 - ko00000,ko02000 antiporter
MANCPEPA_03233 4.81e-124 bioY - - S ko:K03523 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Biotin biosynthesis protein
MANCPEPA_03234 3.92e-156 yuiH - - S - - - Oxidoreductase molybdopterin binding domain
MANCPEPA_03235 8.58e-211 eSD - - S ko:K07017 - ko00000 Putative esterase
MANCPEPA_03236 5.83e-178 dhbA 1.3.1.28 - IQ ko:K00216 ko01053,ko01110,ko01130,map01053,map01110,map01130 ko00000,ko00001,ko01000 Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03237 8.56e-290 dhbC 5.4.4.2 - HQ ko:K02361 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Isochorismate synthase
MANCPEPA_03238 0.0 entE 2.7.7.58, 6.3.2.14 - Q ko:K02363,ko:K04783 ko01053,ko01110,ko01130,map01053,map01110,map01130 ko00000,ko00001,ko01000,ko01008 2,3-dihydroxybenzoate-AMP ligase
MANCPEPA_03239 3.83e-229 dhbB 3.3.2.1, 6.3.2.14 - Q ko:K01252 ko01053,ko01110,ko01130,map01053,map01110,map01130 ko00000,ko00001,ko01000,ko01008 Isochorismatase family
MANCPEPA_03240 0.0 dhbF - - Q ko:K04780 ko01053,map01053 ko00000,ko00001,ko01008 Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MANCPEPA_03241 2.02e-47 mbtH - - S ko:K05375 ko00261,ko01130,map00261,map01130 ko00000,ko00001,ko00002 MbtH-like protein
MANCPEPA_03242 1.2e-168 yukJ - - S - - - Uncharacterized conserved protein (DUF2278)
MANCPEPA_03243 2.33e-261 ald 1.4.1.1 - E ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 ko00000,ko00001,ko01000 Belongs to the AlaDH PNT family
MANCPEPA_03244 1.03e-292 yukF - - QT - - - Transcriptional regulator
MANCPEPA_03245 3.93e-60 yukE - - S - - - Belongs to the WXG100 family
MANCPEPA_03246 1.93e-54 yukD - - S - - - WXG100 protein secretion system (Wss), protein YukD
MANCPEPA_03247 4.28e-271 essB - - S - - - WXG100 protein secretion system (Wss), protein YukC
MANCPEPA_03248 0.0 essC - - D ko:K03466 - ko00000,ko03036 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
MANCPEPA_03249 0.0 yueB - - S - - - type VII secretion protein EsaA
MANCPEPA_03250 7.25e-96 yueC - - S - - - Family of unknown function (DUF5383)
MANCPEPA_03251 3.53e-170 yueD 1.1.1.320 - IQ ko:K16216 - ko00000,ko01000 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_03252 6.39e-124 yueE - - S ko:K06950 - ko00000 phosphohydrolase
MANCPEPA_03253 8.4e-33 - - - S - - - Protein of unknown function (DUF2642)
MANCPEPA_03254 6.59e-92 - - - S - - - Protein of unknown function (DUF2283)
MANCPEPA_03255 2.24e-243 yueF - - S - - - transporter activity
MANCPEPA_03256 1.19e-41 yueG - - S ko:K06299 - ko00000 Spore germination protein gerPA/gerPF
MANCPEPA_03257 1.63e-52 yueH - - S - - - YueH-like protein
MANCPEPA_03258 1.48e-85 - - - S - - - Protein of unknown function (DUF1694)
MANCPEPA_03259 3.27e-134 pncA - - Q ko:K16788 - ko00000,ko02000 COG1335 Amidases related to nicotinamidase
MANCPEPA_03260 0.0 pncB 6.3.4.21 - H ko:K00763 ko00760,ko01100,map00760,map01100 ko00000,ko00001,ko01000 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MANCPEPA_03261 2.4e-297 yuxH - - T - - - signal transduction protein containing EAL and modified HD-GYP domains
MANCPEPA_03262 8.73e-09 yuzC - - - - - - -
MANCPEPA_03263 6.29e-10 - - - S - - - DegQ (SacQ) family
MANCPEPA_03264 8.19e-169 comQ - - H ko:K02251 ko02024,map02024 ko00000,ko00001,ko02044 Belongs to the FPP GGPP synthase family
MANCPEPA_03266 6.08e-188 comP 2.7.13.3 - T ko:K07680 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03267 8.04e-257 comP 2.7.13.3 - T ko:K07680 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03268 2.06e-150 comA - - K ko:K07691 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko00002,ko02022 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MANCPEPA_03269 2.24e-82 yuxO - - Q - - - protein, possibly involved in aromatic compounds catabolism
MANCPEPA_03270 5.97e-79 mrpG - - P ko:K05571 - ko00000,ko02000 COG1320 Multisubunit Na H antiporter, MnhG subunit
MANCPEPA_03271 2.23e-51 mrpF - - P ko:K05570 - ko00000,ko02000 Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MANCPEPA_03272 2.47e-101 mrpE - - P ko:K05569 - ko00000,ko02000 Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MANCPEPA_03273 0.0 mrpD - - CP ko:K05568 - ko00000,ko02000 Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MANCPEPA_03274 1.72e-66 mrpC - - P ko:K05567 - ko00000,ko02000 Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MANCPEPA_03275 7.66e-91 mrpB - - P ko:K05566 - ko00000,ko02000 Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MANCPEPA_03276 0.0 mrpA - - CP ko:K05565 - ko00000,ko02000 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MANCPEPA_03277 3e-23 - - - - - - - -
MANCPEPA_03278 9.73e-310 malP - - C ko:K11616 ko02020,map02020 ko00000,ko00001 COG3493 Na citrate symporter
MANCPEPA_03279 1.21e-215 yufQ - - S ko:K02057 - ko00000,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family
MANCPEPA_03280 1.83e-236 yufP - - S ko:K02057 - ko00000,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family
MANCPEPA_03281 0.0 yufO 3.6.3.17 - S ko:K02056 - ko00000,ko00002,ko01000,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_03282 1.28e-253 tcsA - - S ko:K02058,ko:K07335 - ko00000,ko00002,ko02000 ABC-type transport system, periplasmic component surface lipoprotein
MANCPEPA_03283 3.26e-162 dcuR - - T ko:K02475,ko:K11615 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG4565 Response regulator of citrate malate metabolism
MANCPEPA_03284 0.0 malK 2.7.13.3 - T ko:K11614,ko:K11637,ko:K11691 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Signal transduction histidine kinase regulating citrate malate metabolism
MANCPEPA_03285 4.19e-113 yufK - - S - - - Family of unknown function (DUF5366)
MANCPEPA_03286 3.31e-98 yuxK - - S - - - protein conserved in bacteria
MANCPEPA_03287 0.0 pbpD 2.4.1.129, 3.4.16.4 GT51 M ko:K12555,ko:K18770 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 Penicillin-binding Protein
MANCPEPA_03288 4.61e-244 yuxJ - - EGP - - - Major facilitator superfamily
MANCPEPA_03290 8.49e-150 kapD - - L ko:K06348 - ko00000 the KinA pathway to sporulation
MANCPEPA_03291 1.19e-89 kapB - - G ko:K06347 ko02020,map02020 ko00000,ko00001 Kinase associated protein B
MANCPEPA_03292 1.06e-296 kinB2 2.7.13.3 - T ko:K07697 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03293 1.16e-286 patB 4.4.1.8 - E ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko00000,ko00001,ko01000,ko01007 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
MANCPEPA_03294 8.84e-52 yugE - - S - - - Domain of unknown function (DUF1871)
MANCPEPA_03295 1.64e-199 yugF - - I - - - Hydrolase
MANCPEPA_03296 6.74e-112 alaR - - K - - - Transcriptional regulator
MANCPEPA_03297 5.43e-255 yugH - - E ko:K10907 - ko00000,ko01000,ko01007 Aminotransferase
MANCPEPA_03298 5e-83 yugI - - J ko:K07570,ko:K07571 - ko00000 RNA binding protein (contains ribosomal protein S1 domain)
MANCPEPA_03299 2.21e-46 yuzA - - S ko:K09779 - ko00000 Domain of unknown function (DUF378)
MANCPEPA_03300 2.85e-287 yugJ - - C ko:K19955 - ko00000,ko01000 oxidoreductases, Fe-dependent alcohol dehydrogenase family
MANCPEPA_03301 4.38e-288 yugK - - C ko:K19955 - ko00000,ko01000 Dehydrogenase
MANCPEPA_03302 0.0 pgi 5.3.1.9 - G ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000,ko04147 Belongs to the GPI family
MANCPEPA_03304 9.97e-94 yugN - - S - - - YugN-like family
MANCPEPA_03305 1.45e-232 yugO - - P ko:K10716 - ko00000,ko02000 COG1226 Kef-type K transport systems
MANCPEPA_03306 2.12e-70 mstX - - S - - - Membrane-integrating protein Mistic
MANCPEPA_03307 1.58e-50 - - - - - - - -
MANCPEPA_03308 4.8e-150 yugP - - S ko:K06973 - ko00000 Zn-dependent protease
MANCPEPA_03309 1.03e-299 yugS - - S - - - COG1253 Hemolysins and related proteins containing CBS domains
MANCPEPA_03310 0.0 yugT 3.2.1.10, 3.2.1.20 GH13,GH31 G ko:K01182,ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 ko00000,ko00001,ko01000 COG0366 Glycosidases
MANCPEPA_03311 3.63e-95 yugU - - S - - - Uncharacterised protein family UPF0047
MANCPEPA_03312 1.44e-47 - - - - - - - -
MANCPEPA_03313 6.15e-181 tgl 2.3.2.13 - H ko:K00686 - ko00000,ko01000 Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
MANCPEPA_03314 0.0 mcpB - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_03315 1.31e-294 mcpA - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_03316 0.0 mcpA - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_03317 0.0 mcpA - - NT ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 chemotaxis protein
MANCPEPA_03318 0.0 yuxG - - IQ - - - Class II Aldolase and Adducin N-terminal domain
MANCPEPA_03319 1.42e-172 yulB - - K ko:K02530,ko:K22103 - ko00000,ko03000 COG1349 Transcriptional regulators of sugar metabolism
MANCPEPA_03320 0.0 rhaB 2.7.1.5 - G ko:K00848 ko00040,ko00051,ko01120,map00040,map00051,map01120 ko00000,ko00001,ko01000 Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
MANCPEPA_03321 2.02e-72 rhaM 5.1.3.32 - G ko:K03534 - ko00000,ko01000 Involved in the anomeric conversion of L-rhamnose
MANCPEPA_03322 0.0 rhaA 2.7.1.5, 5.3.1.14 - G ko:K00848,ko:K01813 ko00040,ko00051,ko01120,map00040,map00051,map01120 ko00000,ko00001,ko01000 Belongs to the rhamnose isomerase family
MANCPEPA_03323 9.11e-236 yulF - - S ko:K22230 ko00562,ko01120,map00562,map01120 ko00000,ko00001,ko01000 Oxidoreductase
MANCPEPA_03324 3.12e-255 yubA - - S - - - transporter activity
MANCPEPA_03325 1.73e-182 uppP 3.6.1.27 - V ko:K06153 ko00550,map00550 ko00000,ko00001,ko01000,ko01011 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MANCPEPA_03327 3.95e-113 cdoA 1.13.11.20 - S ko:K00456 ko00270,ko00430,ko01100,map00270,map00430,map01100 ko00000,ko00001,ko01000 Cysteine dioxygenase type I
MANCPEPA_03328 0.0 yubD - - P - - - Major Facilitator Superfamily
MANCPEPA_03329 3.6e-194 - - - NU - - - Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MANCPEPA_03330 3.31e-52 yubF - - S - - - yiaA/B two helix domain
MANCPEPA_03331 8.78e-300 - - - P ko:K03498 - ko00000,ko02000 Potassium
MANCPEPA_03332 1.06e-156 ktrA - - P ko:K03499 - ko00000,ko02000 COG0569 K transport systems, NAD-binding component
MANCPEPA_03333 5.83e-118 yuaB - - - - - - -
MANCPEPA_03334 1.14e-119 yuaC - - K ko:K22109 - ko00000,ko03000 Belongs to the GbsR family
MANCPEPA_03335 0.0 gbsA 1.2.1.8 - C ko:K00130 ko00260,ko01100,map00260,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the aldehyde dehydrogenase family
MANCPEPA_03336 4.26e-292 gbsB 1.1.1.1 - C ko:K11440 ko00260,ko01100,map00260,map01100 ko00000,ko00001,ko00002,ko01000 alcohol dehydrogenase
MANCPEPA_03337 3.5e-138 yuaD - - - - - - -
MANCPEPA_03338 1.95e-109 yuaE - - S - - - DinB superfamily
MANCPEPA_03339 4.82e-109 yuaF - - OU - - - Membrane protein implicated in regulation of membrane protease activity
MANCPEPA_03340 9.14e-258 yuaG - - S ko:K07192 ko04910,map04910 ko00000,ko00001,ko03036,ko04131,ko04147 protein conserved in bacteria
MANCPEPA_03341 9.48e-120 - - - M - - - FR47-like protein
MANCPEPA_03342 7.22e-122 thiT - - S ko:K16789 - ko00000,ko02000 Thiamine transporter protein (Thia_YuaJ)
MANCPEPA_03345 1.43e-226 thiL 2.7.4.16 - H ko:K00946 ko00730,ko01100,map00730,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MANCPEPA_03346 7.42e-112 ydiB - - S ko:K06925 - ko00000,ko03016 ATPase or kinase
MANCPEPA_03347 2.4e-161 yeaZ 2.3.1.234 - O ko:K01409,ko:K14742 - ko00000,ko01000,ko03016 COG1214 Inactive homolog of metal-dependent proteases
MANCPEPA_03348 1.71e-109 rimI 2.3.1.128 - K ko:K03789 - ko00000,ko01000,ko03009 This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MANCPEPA_03349 5.46e-240 tsaD 2.3.1.234 - O ko:K01409 - ko00000,ko01000,ko03016 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MANCPEPA_03350 0.0 ydiF - - S ko:K06158 - ko00000,ko03012 ABC transporter
MANCPEPA_03351 1.46e-117 moaC 4.6.1.17 - H ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 ko00000,ko00001,ko01000 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MANCPEPA_03352 2.14e-148 rex - - K ko:K01926 - ko00000,ko03000 Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MANCPEPA_03353 5.48e-31 tatA - - U ko:K03116 ko03060,ko03070,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MANCPEPA_03354 3.55e-161 tatC - - U ko:K03118 ko03060,ko03070,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MANCPEPA_03355 3.2e-37 ydiK - - S - - - Domain of unknown function (DUF4305)
MANCPEPA_03356 3e-167 ydiL - - S ko:K07052 - ko00000 CAAX protease self-immunity
MANCPEPA_03357 2.14e-58 groS - - O ko:K04078 - ko00000,ko03029,ko03110 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MANCPEPA_03358 0.0 groL - - O ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MANCPEPA_03359 1.56e-181 - - - L - - - Belongs to the 'phage' integrase family
MANCPEPA_03360 3.34e-62 xkdA - - E - - - IrrE N-terminal-like domain
MANCPEPA_03361 1.59e-29 xre - - K - - - transcriptional
MANCPEPA_03362 3.49e-18 - - - K - - - Helix-turn-helix XRE-family like proteins
MANCPEPA_03363 3.95e-47 - - - - - - - -
MANCPEPA_03364 5.24e-50 - - - S - - - DNA binding
MANCPEPA_03365 1.89e-88 - - - - - - - -
MANCPEPA_03370 3.41e-124 - - - - - - - -
MANCPEPA_03371 6.72e-90 pi112 - - L - - - PDDEXK-like domain of unknown function (DUF3799)
MANCPEPA_03373 6.34e-63 yqaL - - L - - - DnaD domain protein
MANCPEPA_03374 1.22e-101 yqaM - - L - - - IstB-like ATP binding protein
MANCPEPA_03377 9.06e-71 - - - S - - - Protein of unknown function (DUF1064)
MANCPEPA_03379 1.3e-36 yqaO - - S - - - Phage-like element PBSX protein XtrA
MANCPEPA_03385 1.96e-62 - - - S - - - dUTPase
MANCPEPA_03391 5.28e-91 xpf - - K ko:K03088 - ko00000,ko03021 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MANCPEPA_03393 1.03e-23 - - - K - - - Transcriptional regulator
MANCPEPA_03394 7.27e-91 - - - - - - - -
MANCPEPA_03395 2.11e-12 - - - - - - - -
MANCPEPA_03396 2.63e-118 yqaS - - L - - - DNA packaging
MANCPEPA_03397 9.35e-236 - - - S - - - Terminase-like family
MANCPEPA_03398 3.21e-195 - - - S - - - Phage portal protein, SPP1 Gp6-like
MANCPEPA_03399 4.34e-88 - - - S - - - Domain of unknown function (DUF4355)
MANCPEPA_03400 4.99e-165 - - - S - - - Phage capsid family
MANCPEPA_03402 1.35e-40 - - - S - - - Phage Mu protein F like protein
MANCPEPA_03404 1.41e-60 - - - - - - - -
MANCPEPA_03406 1.19e-40 - - - - - - - -
MANCPEPA_03407 1.61e-128 - - - S - - - Protein of unknown function (DUF3383)
MANCPEPA_03408 8.46e-46 - - - - - - - -
MANCPEPA_03409 7.49e-22 - - - - - - - -
MANCPEPA_03410 9.22e-173 - - - N - - - phage tail tape measure protein
MANCPEPA_03411 6.22e-47 - - - M - - - LysM domain
MANCPEPA_03412 1.13e-41 - - - - - - - -
MANCPEPA_03413 1.05e-110 - - - - - - - -
MANCPEPA_03415 2.25e-30 - - - S - - - Protein of unknown function (DUF2634)
MANCPEPA_03416 6.04e-134 - - - S - - - homolog of phage Mu protein gp47
MANCPEPA_03417 4.28e-79 - - - - - - - -
MANCPEPA_03418 5.19e-26 - - - - - - - -
MANCPEPA_03421 6.97e-121 - 3.1.4.46, 5.4.2.11 - C ko:K01126,ko:K01834 ko00010,ko00260,ko00564,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00564,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 glycerophosphoryl diester phosphodiesterase
MANCPEPA_03422 1.56e-36 xhlA - - S - - - Haemolysin XhlA
MANCPEPA_03423 2.63e-40 xhlB - - S - - - SPP1 phage holin
MANCPEPA_03424 1.08e-135 - 3.5.1.28 - M ko:K01447 - ko00000,ko01000 N-acetylmuramoyl-L-alanine amidase
MANCPEPA_03427 1.12e-36 - - - K - - - Helix-turn-helix domain
MANCPEPA_03429 2.85e-113 - - - E - - - Zn peptidase
MANCPEPA_03432 4.63e-194 ydjC - - S - - - Abhydrolase domain containing 18
MANCPEPA_03433 0.0 gutR - - K ko:K16247 - ko00000,ko03000 NB-ARC domain
MANCPEPA_03434 1.51e-258 gutB 1.1.1.14 - E ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 ko00000,ko00001,ko00002,ko01000 Dehydrogenase
MANCPEPA_03435 0.0 gutP - - G ko:K03292,ko:K16248 - ko00000,ko02000 MFS/sugar transport protein
MANCPEPA_03436 1.42e-219 ydjE 2.7.1.4 - G ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko00000,ko00001,ko01000 pfkB family carbohydrate kinase
MANCPEPA_03437 9.24e-147 pspA - - KT ko:K03969 - ko00000 Phage shock protein A
MANCPEPA_03438 1.04e-227 ydjG - - L - - - Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MANCPEPA_03439 3.96e-177 ydjH - - S ko:K06872 - ko00000 COG1512 Beta-propeller domains of methanol dehydrogenase type
MANCPEPA_03440 1.79e-203 ydjI - - S - - - virion core protein (lumpy skin disease virus)
MANCPEPA_03441 1.37e-248 - - - S - - - Ion transport 2 domain protein
MANCPEPA_03442 0.0 iolT - - U ko:K02100,ko:K06609,ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MANCPEPA_03443 3.5e-249 ydjL 1.1.1.264, 1.1.1.303, 1.1.1.4 - E ko:K00004,ko:K00098 ko00650,map00650 ko00000,ko00001,ko01000 Dehydrogenase
MANCPEPA_03444 1.79e-84 ydjM - - M - - - Lytic transglycolase
MANCPEPA_03445 2.31e-207 ydjN - - U - - - Involved in the tonB-independent uptake of proteins
MANCPEPA_03447 8.2e-48 ydjO - - S - - - Cold-inducible protein YdjO
MANCPEPA_03448 1.85e-204 - - - I - - - Alpha/beta hydrolase family
MANCPEPA_03449 8.31e-228 yeaA - - S - - - Protein of unknown function (DUF4003)
MANCPEPA_03450 0.0 cotA 1.16.3.3 - Q ko:K06324 - ko00000,ko01000 multicopper oxidases
MANCPEPA_03451 0.0 gabP - - E ko:K11735 - ko00000,ko02000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_03452 1.76e-198 yeaB - - P - - - Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MANCPEPA_03453 2.79e-226 yeaC - - S ko:K03924 - ko00000,ko01000 COG0714 MoxR-like ATPases
MANCPEPA_03454 1.36e-286 yeaD - - S - - - conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
MANCPEPA_03455 0.0 yebA - - E - - - COG1305 Transglutaminase-like enzymes
MANCPEPA_03456 0.0 guaA 6.3.5.2 - F ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 ko00000,ko00001,ko00002,ko01000,ko01002 Catalyzes the synthesis of GMP from XMP
MANCPEPA_03457 3.8e-112 - - - K ko:K03088 - ko00000,ko03021 Belongs to the sigma-70 factor family. ECF subfamily
MANCPEPA_03458 0.0 - - - S - - - Domain of unknown function (DUF4179)
MANCPEPA_03459 2.81e-282 pbuG - - S ko:K06901 - ko00000,ko02000 permease
MANCPEPA_03460 5.85e-165 yebC - - M - - - Membrane
MANCPEPA_03462 1.08e-119 yebE - - S - - - UPF0316 protein
MANCPEPA_03463 3.13e-38 yebG - - S - - - NETI protein
MANCPEPA_03464 1.08e-106 purE 5.4.99.18 - F ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MANCPEPA_03465 6.07e-274 purK 6.3.4.18 - F ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MANCPEPA_03466 6.85e-315 purB 4.3.2.2 - F ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MANCPEPA_03467 2.04e-168 purC 6.3.2.6 - F ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the SAICAR synthetase family
MANCPEPA_03468 3.79e-52 purS 6.3.5.3 - F ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MANCPEPA_03469 1.91e-166 purQ 6.3.5.3 - F ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MANCPEPA_03470 0.0 purL 6.3.5.3 - F ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MANCPEPA_03471 0.0 purF 2.4.2.14 - F ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000,ko01002 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MANCPEPA_03472 1.71e-240 purM 6.3.3.1 - F ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Phosphoribosylformylglycinamidine cyclo-ligase
MANCPEPA_03473 8.88e-138 purN 2.1.2.2 - F ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MANCPEPA_03474 0.0 purH 2.1.2.3, 3.5.4.10 - F ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 ko00000,ko00001,ko00002,ko01000,ko04147 Bifunctional purine biosynthesis protein PurH
MANCPEPA_03475 3.29e-297 purD 6.3.4.13 - F ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the GARS family
MANCPEPA_03476 2.51e-94 - - - K - - - helix_turn_helix ASNC type
MANCPEPA_03477 9.05e-296 - - - E ko:K16263 - ko00000,ko02000 Amino acid permease
MANCPEPA_03478 3.45e-37 - - - S - - - Protein of unknown function (DUF2892)
MANCPEPA_03479 0.0 yerA 3.5.4.2 - F ko:K01486 ko00230,ko01100,map00230,map01100 ko00000,ko00001,ko01000 adenine deaminase
MANCPEPA_03480 7.03e-246 yerB - - S - - - Protein of unknown function (DUF3048) C-terminal domain
MANCPEPA_03481 7.62e-68 yerC - - S - - - protein conserved in bacteria
MANCPEPA_03482 0.0 yerD 1.4.7.1 - E ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 ko00000,ko00001,ko01000 Belongs to the glutamate synthase family
MANCPEPA_03484 9.04e-161 pcrB - - I ko:K07094 - ko00000,ko01000 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MANCPEPA_03485 0.0 pcrA 3.6.4.12 - L ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 ATP-dependent DNA helicase
MANCPEPA_03486 0.0 ligA 6.5.1.2 - L ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 ko00000,ko00001,ko01000,ko03032,ko03400 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MANCPEPA_03487 1.77e-281 camS - - S - - - COG4851 Protein involved in sex pheromone biosynthesis
MANCPEPA_03488 2.45e-250 yerI - - S - - - homoserine kinase type II (protein kinase fold)
MANCPEPA_03489 2.29e-160 sapB - - S ko:K07507 - ko00000,ko02000 MgtC SapB transporter
MANCPEPA_03490 0.0 putP - - E ko:K03307,ko:K11928 - ko00000,ko02000 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANCPEPA_03491 7.37e-61 gatC 6.3.5.6, 6.3.5.7 - J ko:K02435 ko00970,ko01100,map00970,map01100 ko00000,ko00001,ko01000,ko03029 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANCPEPA_03492 0.0 gatA 6.3.5.6, 6.3.5.7 - J ko:K02433 ko00970,ko01100,map00970,map01100 ko00000,ko00001,ko01000,ko03029 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MANCPEPA_03493 0.0 gatB 6.3.5.6, 6.3.5.7 - J ko:K02434 ko00970,ko01100,map00970,map01100 ko00000,ko00001,ko01000,ko03029 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANCPEPA_03494 2.43e-189 yerO - - K - - - Transcriptional regulator
MANCPEPA_03495 0.0 swrC - - V ko:K03296 - ko00000 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MANCPEPA_03496 5.16e-218 dagK 2.7.1.107 - I ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko00000,ko00001,ko01000 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MANCPEPA_03497 0.0 rlmCD 2.1.1.190 - J ko:K03215 - ko00000,ko01000,ko03009 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MANCPEPA_03498 2.31e-194 ddeI 2.1.1.37 - L ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 DNA (cytosine-5-)-methyltransferase activity
MANCPEPA_03499 8.68e-60 - - - L ko:K07458 - ko00000,ko01000,ko03400 May nick specific sequences that contain T G mispairs resulting from m5C-deamination
MANCPEPA_03500 3.45e-123 - - - - - - - -
MANCPEPA_03501 6.17e-111 - - - V - - - Restriction endonuclease
MANCPEPA_03503 1.05e-122 rapA - - S ko:K06359,ko:K06360,ko:K06367 ko02024,map02024 ko00000,ko00001,ko01000 Response regulator aspartate phosphatase
MANCPEPA_03504 6.94e-54 - - - S - - - Immunity protein 22
MANCPEPA_03505 8.28e-228 - - - S - - - Bacterial EndoU nuclease
MANCPEPA_03507 2.44e-127 - - - L - - - endonuclease activity
MANCPEPA_03508 6.41e-207 - 3.4.24.40 - CO ko:K01406 ko01503,map01503 ko00000,ko00001,ko01000,ko01002 amine dehydrogenase activity
MANCPEPA_03509 4.97e-271 rapH - - S ko:K06366 ko02024,map02024 ko00000,ko00001,ko01000 Tetratricopeptide repeat
MANCPEPA_03511 6.29e-162 yeeN - - K - - - transcriptional regulatory protein
MANCPEPA_03513 9.93e-130 dhaR3 - - K ko:K16137 - ko00000,ko03000 Transcriptional regulator
MANCPEPA_03514 4.95e-107 yesE - - S ko:K06893 - ko00000 SnoaL-like domain
MANCPEPA_03515 2.89e-194 yesF - - GM - - - NAD(P)H-binding
MANCPEPA_03516 6.32e-59 cotJA - - S ko:K06332 - ko00000 Spore coat associated protein JA (CotJA)
MANCPEPA_03517 2.31e-61 cotJB - - S ko:K06333 - ko00000 CotJB protein
MANCPEPA_03518 1.04e-133 cotJC - - P ko:K06334 - ko00000 Spore Coat
MANCPEPA_03519 3.28e-128 yesJ - - K - - - Acetyltransferase (GNAT) family
MANCPEPA_03521 8.56e-131 yesL - - S - - - Protein of unknown function, DUF624
MANCPEPA_03522 0.0 yesM 2.7.13.3 - T ko:K07718 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03523 2.31e-256 - - - K ko:K07720 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 helix_turn_helix, arabinose operon control protein
MANCPEPA_03524 1.38e-312 yesO - - G ko:K02027 - ko00000,ko00002,ko02000 Bacterial extracellular solute-binding protein
MANCPEPA_03525 2.02e-218 yesP - - G ko:K02025 - ko00000,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_03526 5.11e-210 - - - P ko:K02026 - ko00000,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_03527 1.96e-254 - 3.2.1.172 GH105 S ko:K15532 - ko00000,ko01000 Glycosyl Hydrolase Family 88
MANCPEPA_03528 0.0 yesS - - K - - - Transcriptional regulator
MANCPEPA_03529 3.56e-171 - - - E - - - GDSL-like Lipase/Acylhydrolase
MANCPEPA_03530 5.73e-169 yesU - - S - - - Domain of unknown function (DUF1961)
MANCPEPA_03531 7.78e-143 - - - S - - - Protein of unknown function, DUF624
MANCPEPA_03532 0.0 - 4.2.2.23, 4.2.2.24 PL11 E ko:K18197,ko:K18198 - ko00000,ko01000 cell wall organization
MANCPEPA_03533 0.0 yesX 4.2.2.23, 4.2.2.24 PL11 E ko:K18197,ko:K18198 - ko00000,ko01000 cell wall organization
MANCPEPA_03534 7.51e-159 - - - E - - - GDSL-like Lipase/Acylhydrolase
MANCPEPA_03535 0.0 - 3.2.1.23 - G ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 ko00000,ko00001,ko01000 beta-galactosidase activity
MANCPEPA_03536 0.0 yetA - - - - - - -
MANCPEPA_03537 0.0 lplA - - G ko:K17318 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Bacterial extracellular solute-binding protein
MANCPEPA_03538 2.78e-225 lplB - - G ko:K17319 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG4209 ABC-type polysaccharide transport system, permease component
MANCPEPA_03539 7.85e-209 - - - G ko:K17320 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Binding-protein-dependent transport system inner membrane component
MANCPEPA_03540 0.0 - 3.2.1.22 - G ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 ko00000,ko00001,ko01000 Family 4 glycosyl hydrolase
MANCPEPA_03541 1.49e-156 yetF - - S - - - membrane
MANCPEPA_03542 4.67e-73 yetG 1.14.99.48 - S ko:K07145 ko00860,ko01110,map00860,map01110 ko00000,ko00001,ko01000 Antibiotic biosynthesis monooxygenase
MANCPEPA_03543 7.08e-85 yetH - - E - - - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_03544 1.58e-182 - - - T ko:K17763 - ko00000,ko03021 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MANCPEPA_03545 3.81e-28 yezD - - S - - - Uncharacterized small protein (DUF2292)
MANCPEPA_03546 2.1e-134 yetJ - - S ko:K06890 - ko00000 Belongs to the BI1 family
MANCPEPA_03547 2.75e-116 yetL - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_03548 2.53e-265 yetM - - CH - - - FAD binding domain
MANCPEPA_03549 2.57e-171 - - - M - - - Membrane
MANCPEPA_03550 4.11e-251 yetN - - S - - - Protein of unknown function (DUF3900)
MANCPEPA_03551 0.0 cypD 1.14.14.1, 1.6.2.4 - C ko:K14338 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 ko00000,ko00001,ko00199,ko01000 Belongs to the cytochrome P450 family
MANCPEPA_03552 0.0 ltaS 2.7.8.20 - M ko:K19005 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko01000 Belongs to the LTA synthase family
MANCPEPA_03553 2.15e-190 yfnH 2.7.7.33 - JM ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 ko00000,ko00001,ko01000 Nucleotidyl transferase
MANCPEPA_03554 4.79e-220 yfnG 4.2.1.45, 4.2.1.46 - M ko:K01709,ko:K01710 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 ko00000,ko00001,ko00002,ko01000 dehydratase
MANCPEPA_03555 1.9e-229 yfnF - - M - - - Nucleotide-diphospho-sugar transferase
MANCPEPA_03556 2.44e-286 yfnE - - S - - - Glycosyltransferase like family 2
MANCPEPA_03557 2.34e-243 yfnD - - M - - - Nucleotide-diphospho-sugar transferase
MANCPEPA_03558 6.21e-268 fsr - - P ko:K08223 - ko00000,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03559 3.84e-170 yfnB 3.8.1.2 - S ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 ko00000,ko00001,ko01000 Haloacid dehalogenase-like hydrolase
MANCPEPA_03560 2.4e-312 yfnA - - E ko:K03294 - ko00000 amino acid
MANCPEPA_03561 0.0 yfmT 1.2.1.3, 1.2.1.67 - C ko:K00128,ko:K21802 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MANCPEPA_03562 5.14e-161 yfmS - - NT - - - chemotaxis protein
MANCPEPA_03563 0.0 yfmR - - S ko:K15738 - ko00000,ko02000 COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MANCPEPA_03564 3.75e-98 yfmQ - - S - - - Uncharacterised protein from bacillus cereus group
MANCPEPA_03565 1.44e-89 yfmP - - K ko:K21902 - ko00000,ko03000 transcriptional
MANCPEPA_03566 3.59e-265 yfmO - - EGP ko:K08221 - ko00000,ko02000 Major facilitator superfamily
MANCPEPA_03567 0.0 yheS_1 - - S - - - COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MANCPEPA_03568 1.2e-262 yfmL - - L - - - COG0513 Superfamily II DNA and RNA helicases
MANCPEPA_03569 2.55e-105 yfmK 2.3.1.128 - K ko:K03790 - ko00000,ko01000,ko03009 acetyltransferase
MANCPEPA_03570 6.98e-241 yfmJ - - S ko:K07119 - ko00000 N-terminal domain of oxidoreductase
MANCPEPA_03571 1.72e-268 - - - G - - - Major Facilitator Superfamily
MANCPEPA_03572 0.0 pkn1 - - S - - - Sulfatase-modifying factor enzyme 1
MANCPEPA_03573 1.4e-192 fhuC 3.6.3.34 - P ko:K02013 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ATPases associated with a variety of cellular activities
MANCPEPA_03574 2.73e-219 fecD - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03575 4.72e-220 - - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03576 6.5e-218 yfmC - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
MANCPEPA_03577 4.26e-31 - - - S - - - Protein of unknown function (DUF3212)
MANCPEPA_03578 1.71e-76 yflT - - S - - - Heat induced stress protein YflT
MANCPEPA_03579 1.42e-306 pel 4.2.2.2 - G ko:K01728 ko00040,ko02024,map00040,map02024 ko00000,ko00001,ko01000 Pectate lyase
MANCPEPA_03580 0.0 yflS - - P ko:K03319 - ko00000 Sodium:sulfate symporter transmembrane region
MANCPEPA_03581 0.0 citS 2.7.13.3 - T ko:K11614,ko:K11637,ko:K11691 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Signal transduction histidine kinase regulating citrate malate metabolism
MANCPEPA_03582 3.96e-154 citT - - T ko:K11638 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 response regulator
MANCPEPA_03583 1.97e-230 yflP - - S - - - Tripartite tricarboxylate transporter family receptor
MANCPEPA_03584 1.53e-287 citM - - C ko:K03300,ko:K11639 ko02020,map02020 ko00000,ko00001 Citrate transporter
MANCPEPA_03585 7.21e-194 yflN - - S - - - COG0491 Zn-dependent hydrolases, including glyoxylases
MANCPEPA_03586 1.67e-276 nos 1.14.14.47 - C ko:K00491 ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MANCPEPA_03587 2.54e-60 acyP 3.6.1.7 - C ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 ko00000,ko00001,ko01000 Belongs to the acylphosphatase family
MANCPEPA_03588 2.51e-159 yflK - - S - - - protein conserved in bacteria
MANCPEPA_03589 1.1e-25 yflJ - - S - - - Protein of unknown function (DUF2639)
MANCPEPA_03590 2.82e-26 yflI - - - - - - -
MANCPEPA_03591 2.1e-65 yflH - - S - - - Protein of unknown function (DUF3243)
MANCPEPA_03592 6.62e-178 yflG 3.4.11.18 - E ko:K01265 - ko00000,ko01000,ko01002 Methionine aminopeptidase
MANCPEPA_03593 0.0 nagE 2.7.1.193, 2.7.1.199 - G ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
MANCPEPA_03594 0.0 yflE 2.7.8.20 - M ko:K19005 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko01000 Belongs to the LTA synthase family
MANCPEPA_03595 1.89e-87 ydhN1 - - S - - - Domain of unknown function (DUF1992)
MANCPEPA_03596 0.0 yflA - - E ko:K03310 - ko00000 Sodium alanine symporter
MANCPEPA_03597 9.97e-246 yfkT - - E ko:K06309 - ko00000 Spore germination protein
MANCPEPA_03599 6.53e-271 yfkR - - S ko:K06297,ko:K06308 - ko00000 spore germination
MANCPEPA_03600 3.61e-299 yfkQ - - EG ko:K06295,ko:K06307 - ko00000 Spore germination protein
MANCPEPA_03601 2.2e-32 yfkQ - - EG ko:K06295,ko:K06307 - ko00000 Spore germination protein
MANCPEPA_03602 0.0 treP 2.7.1.201 - G ko:K02818,ko:K02819 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_03603 0.0 treC 3.2.1.93 GH13 G ko:K01226 ko00500,map00500 ko00000,ko00001,ko01000 COG0366 Glycosidases
MANCPEPA_03604 1.24e-172 treR - - K ko:K03486 - ko00000,ko03000 transcriptional
MANCPEPA_03605 6.16e-160 frp - - C - - - nitroreductase
MANCPEPA_03606 0.0 yfkN 3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45 - F ko:K01081,ko:K01119,ko:K06931,ko:K08693,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko00000,ko00001,ko01000 Belongs to the 5'-nucleotidase family
MANCPEPA_03607 5.48e-114 yfkM 3.5.1.124 - S ko:K05520 - ko00000,ko01000,ko01002 protease
MANCPEPA_03608 1.03e-264 ydiN3 - - EGP - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03609 5.99e-41 yfkK - - S - - - Belongs to the UPF0435 family
MANCPEPA_03610 8.37e-108 yfkJ 3.1.3.48 - T ko:K01104 - ko00000,ko01000 Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MANCPEPA_03611 1.03e-66 yfkI - - S - - - gas vesicle protein
MANCPEPA_03612 9.64e-184 yihY - - S ko:K07058 - ko00000 Belongs to the UPF0761 family
MANCPEPA_03613 1.64e-12 - - - - - - - -
MANCPEPA_03614 1.9e-278 yfkF - - EGP - - - COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03615 1.34e-235 cax - - P ko:K07300 - ko00000,ko02000 COG0387 Ca2 H antiporter
MANCPEPA_03616 3.69e-189 yfkD - - S - - - YfkD-like protein
MANCPEPA_03617 8.97e-191 yfkC - - M - - - Mechanosensitive ion channel
MANCPEPA_03618 1.76e-283 yfkA - - S - - - YfkB-like domain
MANCPEPA_03619 3.26e-36 yfjT - - - - - - -
MANCPEPA_03620 5.95e-197 pdaA - - G ko:K01567 - ko00000,ko01000 deacetylase
MANCPEPA_03621 1.38e-193 yfjR - - I - - - NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MANCPEPA_03622 7.8e-237 corA - - P ko:K03284 - ko00000,ko02000 Mediates influx of magnesium ions
MANCPEPA_03623 2.76e-214 yfjP 3.2.2.21 - L ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MANCPEPA_03624 0.0 rumA_1 2.1.1.190, 2.1.1.35 - J ko:K00557,ko:K03215 - ko00000,ko01000,ko03009,ko03016 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MANCPEPA_03625 3.04e-59 - - - S - - - YfzA-like protein
MANCPEPA_03626 1.25e-236 yfjN - - J - - - Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MANCPEPA_03627 1.47e-105 yfjM - - S - - - Psort location Cytoplasmic, score
MANCPEPA_03628 1.94e-244 acoA - - C ko:K21416 - ko00000,ko01000 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MANCPEPA_03629 4.37e-241 acoB - - C ko:K21417 - ko00000,ko01000 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MANCPEPA_03630 6.94e-264 acoC 2.3.1.12 - C ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MANCPEPA_03631 0.0 acoL 1.8.1.4 - C ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MANCPEPA_03632 0.0 acoR - - KQ ko:K21405 - ko00000,ko03000 COG3284 Transcriptional activator of acetoin glycerol metabolism
MANCPEPA_03633 8.16e-36 sspH - - S ko:K06425 - ko00000 Belongs to the SspH family
MANCPEPA_03634 1.23e-73 yfjF - - S ko:K09771 - ko00000,ko02000 UPF0060 membrane protein
MANCPEPA_03635 1.34e-109 - - - S - - - Family of unknown function (DUF5381)
MANCPEPA_03636 1.45e-159 yfjC - - - - - - -
MANCPEPA_03637 5.94e-242 yfjB - - - - - - -
MANCPEPA_03638 1.87e-59 yfjA - - S - - - Belongs to the WXG100 family
MANCPEPA_03639 0.0 malH 3.2.1.122 GH4 G ko:K01232 ko00500,map00500 ko00000,ko00001,ko01000 COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MANCPEPA_03640 8.69e-181 - - - K ko:K03481 - ko00000,ko03000 Helix-turn-helix domain, rpiR family
MANCPEPA_03641 0.0 glvC 2.7.1.208 - G ko:K02749,ko:K02750 ko00500,ko02060,map00500,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_03642 0.0 yfiB3 - - V ko:K06147 - ko00000,ko02000 ABC transporter
MANCPEPA_03643 0.0 yfiC3 - - V ko:K06147 - ko00000,ko02000 COG1132 ABC-type multidrug transport system, ATPase and permease components
MANCPEPA_03644 3.34e-83 yfiD3 - - S - - - DoxX
MANCPEPA_03645 4.21e-208 yfiE 1.13.11.2 - S ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 ko00000,ko00001,ko00002,ko01000 glyoxalase
MANCPEPA_03647 1.98e-271 baeS - - T - - - Histidine kinase
MANCPEPA_03648 6.07e-146 yfiK - - KT ko:K02479 - ko00000,ko02022 LuxR family transcriptional regulator
MANCPEPA_03649 7.89e-217 drrA - - V ko:K01990,ko:K09695 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_03650 4.18e-264 - - - V ko:K01992 - ko00000,ko00002,ko02000 ABC-2 family transporter protein
MANCPEPA_03651 5.45e-259 - - - V ko:K01992 - ko00000,ko00002,ko02000 COG0842 ABC-type multidrug transport system, permease component
MANCPEPA_03652 2.21e-127 padR - - K - - - transcriptional
MANCPEPA_03653 7.87e-128 lip 3.1.1.3 - S ko:K01046 ko00561,ko01100,map00561,map01100 ko00000,ko00001,ko00002,ko01000 acetyltransferases and hydrolases with the alpha beta hydrolase fold
MANCPEPA_03654 2.29e-253 yfiQ - - G ko:K21462 - ko00000 COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MANCPEPA_03655 9.43e-127 yfiT - - S - - - Belongs to the metal hydrolase YfiT family
MANCPEPA_03656 0.0 yfiU - - EGP - - - the major facilitator superfamily
MANCPEPA_03657 1.04e-103 yfiV - - K - - - transcriptional
MANCPEPA_03658 0.0 mprF 2.3.2.3 - S ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 ko00000,ko00001,ko00002,ko01000,ko01504 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MANCPEPA_03659 5e-227 yfiY - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter substrate-binding protein
MANCPEPA_03660 1.54e-225 yfiZ - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03661 7.05e-227 yfhA - - P ko:K02015 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANCPEPA_03662 2.09e-212 yfhB - - S - - - PhzF family
MANCPEPA_03663 2.87e-138 yfhC - - C - - - nitroreductase
MANCPEPA_03664 8.86e-35 yfhD - - S - - - YfhD-like protein
MANCPEPA_03666 2.19e-219 yfhF - - S ko:K07071 - ko00000 nucleoside-diphosphate sugar epimerase
MANCPEPA_03667 3.25e-181 recX - - S ko:K03565 - ko00000,ko03400 Modulates RecA activity
MANCPEPA_03668 4.58e-69 yfhH - - S - - - Protein of unknown function (DUF1811)
MANCPEPA_03669 9.96e-268 yfhI - - EGP - - - -transporter
MANCPEPA_03670 7.57e-26 sspK - - S ko:K06428 - ko00000 reproduction
MANCPEPA_03671 8.95e-60 yfhJ - - S - - - WVELL protein
MANCPEPA_03672 2.32e-115 yfhK - - T - - - Bacterial SH3 domain homologues
MANCPEPA_03673 5.4e-67 yfhL - - S - - - SdpI/YhfL protein family
MANCPEPA_03674 1.08e-215 yfhM 3.8.1.5 - S ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 ko00000,ko00001,ko01000 Alpha beta hydrolase
MANCPEPA_03675 3.43e-236 csbB - GT2 M ko:K20534 - ko00000,ko01000,ko01005,ko02000 COG0463 Glycosyltransferases involved in cell wall biogenesis
MANCPEPA_03676 0.0 yfhO - - S - - - Bacterial membrane protein YfhO
MANCPEPA_03677 7.22e-237 yfhP - - S ko:K07038 - ko00000 membrane-bound metal-dependent
MANCPEPA_03678 8.47e-268 mutY - - L ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 A G-specific
MANCPEPA_03679 4.96e-48 yfhS - - - - - - -
MANCPEPA_03680 3.13e-172 fabL 1.3.1.104 - IQ ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 ko00000,ko00001,ko00002,ko01000,ko01004 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MANCPEPA_03681 2.35e-14 sspE - - S ko:K06422 - ko00000 Small, acid-soluble spore protein, gamma-type
MANCPEPA_03682 2.01e-49 ygaB - - S - - - YgaB-like protein
MANCPEPA_03683 8.1e-136 ygaC - - J ko:K07586 - ko00000 Belongs to the UPF0374 family
MANCPEPA_03684 0.0 ygaD - - V ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 ABC transporter
MANCPEPA_03685 2.65e-238 ygaE - - S - - - Membrane
MANCPEPA_03686 3.26e-312 gsaB 5.4.3.8 - H ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko00000,ko00001,ko00002,ko01000,ko01007 Glutamate-1-semialdehyde aminotransferase
MANCPEPA_03687 8.36e-113 bcp 1.11.1.15 - O ko:K03564 - ko00000,ko01000 Peroxiredoxin
MANCPEPA_03688 2.37e-104 perR - - P ko:K09825 - ko00000,ko03000 Belongs to the Fur family
MANCPEPA_03689 3.38e-73 ygzB - - S - - - UPF0295 protein
MANCPEPA_03690 2.36e-214 ygxA - - S - - - Nucleotidyltransferase-like
MANCPEPA_03691 8.72e-100 ctsR - - K ko:K03708 - ko00000,ko03000 Belongs to the CtsR family
MANCPEPA_03692 2.36e-74 mcsA - - S ko:K19411 - ko00000 protein with conserved CXXC pairs
MANCPEPA_03693 7.74e-257 mcsB 2.7.14.1 - E ko:K19405 - ko00000,ko01000 Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
MANCPEPA_03694 0.0 clpC - - O ko:K03696 ko01100,map01100 ko00000,ko03110 Belongs to the ClpA ClpB family
MANCPEPA_03695 0.0 radA - - O ko:K04485 - ko00000,ko03400 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MANCPEPA_03696 3.8e-251 disA 2.7.7.85 - L ko:K07067 - ko00000,ko01000 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MANCPEPA_03697 2.57e-252 yacL - - S - - - COG4956 Integral membrane protein (PIN domain superfamily)
MANCPEPA_03698 7.42e-162 ispD 2.7.7.60 - I ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MANCPEPA_03699 6.35e-113 ispF 2.7.7.60, 4.6.1.12 - I ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MANCPEPA_03700 0.0 gltX 6.1.1.24 - J ko:K09698 ko00970,ko01100,map00970,map01100 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MANCPEPA_03701 1.91e-152 cysE 2.3.1.30 - E ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 ko00000,ko00001,ko00002,ko01000 Serine acetyltransferase
MANCPEPA_03702 0.0 cysS 6.1.1.16 - J ko:K01883 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Belongs to the class-I aminoacyl-tRNA synthetase family
MANCPEPA_03703 1.68e-94 mrnC - - J ko:K11145 - ko00000,ko01000,ko03009 Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MANCPEPA_03704 3.52e-173 trmH 2.1.1.185 - J ko:K03218 - ko00000,ko01000,ko03009 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MANCPEPA_03705 3.31e-114 yacP - - S ko:K06962 - ko00000 RNA-binding protein containing a PIN domain
MANCPEPA_03706 3.27e-149 sigH - - K ko:K03088,ko:K03091,ko:K12296 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko03000,ko03021 Belongs to the sigma-70 factor family
MANCPEPA_03707 2.65e-32 secE - - U ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MANCPEPA_03708 1.37e-124 nusG - - K ko:K02601 - ko00000,ko03009,ko03021 Participates in transcription elongation, termination and antitermination
MANCPEPA_03709 3.4e-93 rplK - - J ko:K02867 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MANCPEPA_03710 1.82e-162 rplA - - J ko:K02863 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MANCPEPA_03711 4.03e-104 rplJ - - J ko:K02864 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MANCPEPA_03712 2.84e-64 rplL - - J ko:K02935 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MANCPEPA_03713 2.08e-139 rsmC 2.1.1.172 - J ko:K00564 - ko00000,ko01000,ko03009 Methyltransferase
MANCPEPA_03714 0.0 rpoB 2.7.7.6 - K ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MANCPEPA_03715 0.0 rpoC 2.7.7.6 - K ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MANCPEPA_03716 1.99e-44 rplGB - - J ko:K07590 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the eukaryotic ribosomal protein eL8 family
MANCPEPA_03717 6.67e-94 rpsL - - J ko:K02950 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MANCPEPA_03718 4.85e-107 rpsG - - J ko:K02992 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MANCPEPA_03719 0.0 fusA - - J ko:K02355 - ko00000,ko03012,ko03029 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MANCPEPA_03720 2.01e-287 tuf - - J ko:K02358 - ko00000,ko03012,ko03029,ko04147 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MANCPEPA_03721 8.68e-229 ybaC - - S - - - Alpha/beta hydrolase family
MANCPEPA_03722 2.58e-65 rpsJ - - J ko:K02946 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Involved in the binding of tRNA to the ribosomes
MANCPEPA_03723 7.2e-144 rplC - - J ko:K02906 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MANCPEPA_03724 7.43e-136 rplD - - J ko:K02926 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Forms part of the polypeptide exit tunnel
MANCPEPA_03725 3.27e-58 rplW - - J ko:K02892 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MANCPEPA_03726 2.72e-200 rplB - - J ko:K02886 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MANCPEPA_03727 2.83e-62 rpsS - - J ko:K02965 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MANCPEPA_03728 9.23e-71 rplV - - J ko:K02890 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MANCPEPA_03729 1.69e-151 rpsC - - J ko:K02982 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MANCPEPA_03730 1.96e-98 rplP - - J ko:K02878 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MANCPEPA_03731 1.88e-35 rpmC - - J ko:K02904 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the universal ribosomal protein uL29 family
MANCPEPA_03732 1.64e-52 rpsQ - - J ko:K02961 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MANCPEPA_03733 3.62e-79 rplN - - J ko:K02874 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MANCPEPA_03734 1.43e-67 rplX - - J ko:K02895 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MANCPEPA_03735 7.72e-122 rplE - - J ko:K02931 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MANCPEPA_03736 1.43e-39 rpsN - - J ko:K02954 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANCPEPA_03737 3.11e-87 rpsH - - J ko:K02994 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MANCPEPA_03738 4.47e-121 rplF - - J ko:K02933 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MANCPEPA_03739 2.89e-75 rplR - - J ko:K02881 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MANCPEPA_03740 9.16e-111 rpsE - - J ko:K02988 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MANCPEPA_03741 1.59e-33 rpmD - - J ko:K02907 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Ribosomal protein L30
MANCPEPA_03742 7.32e-95 rplO - - J ko:K02876 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 binds to the 23S rRNA
MANCPEPA_03743 5.7e-298 secY - - U ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MANCPEPA_03744 2.51e-157 adk 2.7.4.3 - F ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MANCPEPA_03745 2.32e-182 map 3.4.11.18 - E ko:K01265 - ko00000,ko01000,ko01002 Methionine aminopeptidase
MANCPEPA_03746 2.92e-46 infA - - J ko:K02518 - ko00000,ko03012 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MANCPEPA_03747 2.45e-19 rpmJ - - J ko:K02919 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the bacterial ribosomal protein bL36 family
MANCPEPA_03748 1.09e-75 rpsM - - J ko:K02952 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MANCPEPA_03749 3.24e-84 rpsK - - J ko:K02948 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MANCPEPA_03750 7.01e-217 rpoA 2.7.7.6 - K ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MANCPEPA_03751 4.27e-77 rplQ - - J ko:K02879 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Ribosomal protein L17
MANCPEPA_03752 3.05e-199 ecfA1 - - P ko:K16786 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MANCPEPA_03753 1.28e-195 ecfA2 - - P ko:K16787 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MANCPEPA_03754 1.6e-177 ecfT - - P ko:K16785 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MANCPEPA_03755 1.51e-182 truA 5.4.99.12 - J ko:K06173 - ko00000,ko01000,ko03016 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MANCPEPA_03756 1.13e-102 rplM - - J ko:K02871 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MANCPEPA_03757 4.28e-84 rpsI - - J ko:K02996 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Belongs to the universal ribosomal protein uS9 family
MANCPEPA_03758 2.14e-186 ybaJ - - Q - - - Methyltransferase domain
MANCPEPA_03759 2.54e-91 ybaK - - S - - - Protein of unknown function (DUF2521)
MANCPEPA_03760 2.22e-170 cwlD 3.5.1.28 - M ko:K01448 ko01503,map01503 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 n-acetylmuramoyl-L-alanine amidase
MANCPEPA_03761 1.1e-255 mrp - - D ko:K03593 - ko00000,ko03029,ko03036 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MANCPEPA_03762 1.04e-122 gerD - - - ko:K06294 - ko00000 -
MANCPEPA_03763 5.95e-133 kbaA - - S ko:K06349 - ko00000 Involved in the activation of the KinB signaling pathway of sporulation
MANCPEPA_03764 4.31e-181 pdaB - - G - - - Polysaccharide deacetylase
MANCPEPA_03765 1.13e-53 - - - S - - - COG NOG14552 non supervised orthologous group
MANCPEPA_03766 0.0 gyrA 5.99.1.3 - L ko:K02469 - ko00000,ko01000,ko03032,ko03400 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANCPEPA_03767 0.0 gyrB 5.99.1.3 - L ko:K02470 - ko00000,ko01000,ko03032,ko03400 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANCPEPA_03768 1.25e-51 yaaB - - S - - - Domain of unknown function (DUF370)
MANCPEPA_03769 4.54e-264 recF - - L ko:K03629 ko03440,map03440 ko00000,ko00001,ko03400 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANCPEPA_03770 2.24e-45 yaaA - - S ko:K14761 - ko00000,ko03009 S4 domain
MANCPEPA_03771 1.71e-263 dnaN 2.7.7.7 - L ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MANCPEPA_03772 0.0 dnaA - - L ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MANCPEPA_03773 5.7e-71 rnpA 3.1.26.5 - J ko:K03536 - ko00000,ko01000,ko03016 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MANCPEPA_03774 9.29e-179 yidC - - U ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 ko00000,ko00001,ko00002,ko02044,ko03029 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MANCPEPA_03775 1.83e-141 jag - - S ko:K06346 - ko00000 single-stranded nucleic acid binding R3H
MANCPEPA_03776 4.53e-316 mnmE - - S ko:K03650 - ko00000,ko01000,ko03016 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MANCPEPA_03777 0.0 gidA - - D ko:K03495 - ko00000,ko03016,ko03036 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MANCPEPA_03778 1.01e-167 rsmG 2.1.1.170 - J ko:K03501 - ko00000,ko01000,ko03009,ko03036 Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
MANCPEPA_03779 9e-193 noc - - D ko:K03497 - ko00000,ko03000,ko03036,ko04812 Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
MANCPEPA_03780 9.26e-98 - - - S - - - Bacterial PH domain
MANCPEPA_03781 4.79e-173 soj - - D ko:K03496 - ko00000,ko03036,ko04812 COG1192 ATPases involved in chromosome partitioning
MANCPEPA_03782 1.13e-190 spo0J - - K ko:K03497 - ko00000,ko03000,ko03036,ko04812 Belongs to the ParB family
MANCPEPA_03783 4.53e-145 yyaC - - S - - - Sporulation protein YyaC
MANCPEPA_03784 1.08e-226 yyaD - - S - - - Membrane
MANCPEPA_03785 7.41e-45 yyzM - - S - - - protein conserved in bacteria
MANCPEPA_03786 0.0 yyaE - - C - - - Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MANCPEPA_03787 4.64e-255 ychF - - J ko:K06942 - ko00000,ko03009 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MANCPEPA_03788 1.01e-61 rpsF - - J ko:K02990 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Binds together with S18 to 16S ribosomal RNA
MANCPEPA_03789 1.81e-103 ssb - - L ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MANCPEPA_03790 4.25e-49 rpsR - - J ko:K02963 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MANCPEPA_03791 1.63e-184 exoA 3.1.11.2 - L ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 exodeoxyribonuclease III
MANCPEPA_03792 2.05e-228 ccpB - - K - - - Transcriptional regulator
MANCPEPA_03793 1.45e-89 yyaH 4.4.1.5 - E ko:K01759 ko00620,map00620 ko00000,ko00001,ko01000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_03794 1.55e-128 vatD 2.3.1.28, 2.3.1.79 - S ko:K00638,ko:K00661,ko:K18234 - br01600,ko00000,ko01000,ko01504 Bacterial transferase hexapeptide (six repeats)
MANCPEPA_03795 0.0 - - - EGP ko:K08369 - ko00000,ko02000 Major facilitator superfamily
MANCPEPA_03796 2.1e-215 yyaK - - S ko:K07052 - ko00000 CAAX protease self-immunity
MANCPEPA_03797 0.0 yyaL - - O ko:K06888 - ko00000 COG1331 Highly conserved protein containing a thioredoxin domain
MANCPEPA_03798 0.0 tetL - - EGP ko:K08168 - ko00000,ko00002,ko01504,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03799 2.89e-135 yyaP - - H - - - RibD C-terminal domain
MANCPEPA_03800 1.05e-85 - - - S - - - YjbR
MANCPEPA_03801 2.72e-119 - - - K ko:K19273 - ko00000,ko01000,ko01504 Acetyltransferase (GNAT) domain
MANCPEPA_03802 1.74e-124 yyaS - - S ko:K07149 - ko00000 Membrane
MANCPEPA_03803 2.85e-93 yjcF - - S - - - Acetyltransferase (GNAT) domain
MANCPEPA_03804 4.54e-100 yybA - - K - - - transcriptional
MANCPEPA_03805 1.03e-162 - - - S - - - Metallo-beta-lactamase superfamily
MANCPEPA_03806 1.66e-95 yybC - - - - - - -
MANCPEPA_03807 2.18e-101 yjcF - - S - - - Acetyltransferase (GNAT) domain
MANCPEPA_03808 7.57e-210 yybE - - K - - - Transcriptional regulator
MANCPEPA_03809 8.32e-275 yybF - - EGP ko:K08224 - ko00000,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03810 5.67e-162 yybG - - S - - - Pentapeptide repeat-containing protein
MANCPEPA_03811 2.49e-87 - - - S - - - SnoaL-like domain
MANCPEPA_03812 7.14e-184 - - - - - - - -
MANCPEPA_03813 1.46e-140 - - - K - - - TipAS antibiotic-recognition domain
MANCPEPA_03814 1.01e-307 yybO - - G ko:K03535,ko:K08191 - ko00000,ko02000 COG0477 Permeases of the major facilitator superfamily
MANCPEPA_03816 3.67e-80 - - - - - - - -
MANCPEPA_03817 4.89e-210 ppaC 3.6.1.1 - C ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000 Inorganic pyrophosphatase
MANCPEPA_03818 6.43e-88 yybR - - K - - - Transcriptional regulator
MANCPEPA_03819 6.83e-109 cotF - - M ko:K06329 - ko00000 Spore coat protein
MANCPEPA_03821 1.5e-204 yybS - - S - - - membrane
MANCPEPA_03822 0.0 yybT - - T - - - signaling protein consisting of a modified GGDEF domain and a DHH domain
MANCPEPA_03823 2.74e-96 rplI - - J ko:K02939 ko03010,map03010 br01610,ko00000,ko00001,ko00002,ko03011 binds to the 23S rRNA
MANCPEPA_03824 0.0 ykcB - - M - - - COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MANCPEPA_03825 4.19e-283 yycB - - P ko:K03449 - ko00000,ko02000 COG2807 Cyanate permease
MANCPEPA_03826 1.89e-22 yycC - - K - - - YycC-like protein
MANCPEPA_03828 3.48e-40 yycD - - S - - - Uncharacterized protein conserved in bacteria (DUF2188)
MANCPEPA_03829 0.0 dnaB 3.6.4.12 - L ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Participates in initiation and elongation during chromosome replication
MANCPEPA_03830 3.29e-99 yycE - - E - - - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MANCPEPA_03831 1.29e-314 purA 6.3.4.4 - F ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 ko00000,ko00001,ko00002,ko01000 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MANCPEPA_03836 1.45e-172 yycF - - T ko:K07668 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_03837 0.0 vicK 2.7.13.3 - T ko:K07652 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03838 0.0 yycH - - S - - - protein conserved in bacteria
MANCPEPA_03839 1.63e-198 yycI - - S - - - protein conserved in bacteria
MANCPEPA_03840 4.68e-190 vicX 3.1.26.11 - S ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
MANCPEPA_03841 1.56e-277 yyxA 3.4.21.107 - O ko:K04771 ko01503,ko02020,map01503,map02020 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANCPEPA_03842 0.0 rocR - - KT ko:K06714 - ko00000,ko03000 COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
MANCPEPA_03843 5.02e-55 sdpR - - K - - - transcriptional
MANCPEPA_03844 2.27e-86 yvaZ - - S - - - Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
MANCPEPA_03845 2.74e-31 - - - S - - - Sporulation delaying protein SdpA
MANCPEPA_03846 1.7e-119 - - - - - - - -
MANCPEPA_03847 5.82e-20 - - - - - - - -
MANCPEPA_03848 1.5e-296 rocD 2.6.1.13 - E ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 ko00000,ko00001,ko01000,ko01007 Catalyzes the interconversion of ornithine to glutamate semialdehyde
MANCPEPA_03849 0.0 rocE - - E ko:K02205,ko:K16235,ko:K16236 - ko00000,ko02000 amino acid
MANCPEPA_03850 3.22e-213 rocF 3.5.3.1 - E ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 ko00000,ko00001,ko00002,ko01000 Belongs to the arginase family
MANCPEPA_03852 1.23e-238 - - - S - - - aspartate phosphatase
MANCPEPA_03853 8.71e-110 yycN - - K - - - Acetyltransferase
MANCPEPA_03854 1.68e-169 yycO - - S - - - Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MANCPEPA_03855 1.02e-280 yycP - - - - - - -
MANCPEPA_03856 1.7e-45 yycQ - - S - - - Protein of unknown function (DUF2651)
MANCPEPA_03858 1.05e-296 yycR 1.1.1.1, 1.1.1.284, 1.2.1.46 - E ko:K00121,ko:K00148 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 ko00000,ko00001,ko01000 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MANCPEPA_03859 1.77e-84 - - - - - - - -
MANCPEPA_03861 5e-106 rlmH 2.1.1.177 - J ko:K00783 - ko00000,ko01000,ko03009 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MANCPEPA_03862 7.13e-161 - - - S - - - AIPR protein
MANCPEPA_03863 0.0 fbp 3.1.3.11 - G ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Firmicute fructose-1,6-bisphosphatase
MANCPEPA_03864 7.79e-56 aapA - - E ko:K03293,ko:K11737 - ko00000,ko02000 COG1113 Gamma-aminobutyrate permease and related permeases
MANCPEPA_03866 0.0 ahpF - - O ko:K03387 - ko00000,ko01000 Alkyl hydroperoxide reductase
MANCPEPA_03867 9.33e-136 ahpC 1.11.1.15 - O ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Alkyl hydroperoxide reductase
MANCPEPA_03868 0.0 gntZ 1.1.1.343, 1.1.1.44 - G ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MANCPEPA_03869 2.05e-295 gntP - - EG ko:K03299 - ko00000,ko02000 COG2610 H gluconate symporter and related permeases
MANCPEPA_03870 0.0 gntK 2.7.1.12 - G ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko00000,ko00001,ko01000 Belongs to the FGGY kinase family
MANCPEPA_03871 4.42e-164 gntR - - K ko:K11476 - ko00000,ko03000 transcriptional
MANCPEPA_03872 4.71e-263 glxK 2.7.1.165 - G ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 ko00000,ko00001,ko01000 Belongs to the glycerate kinase type-1 family
MANCPEPA_03873 8.52e-244 - - - GM ko:K19426 - ko00000,ko01000 Polysaccharide pyruvyl transferase
MANCPEPA_03874 1.27e-152 yxaC - - M - - - effector of murein hydrolase
MANCPEPA_03875 2.53e-78 - - - S ko:K06518 - ko00000,ko02000 LrgA family
MANCPEPA_03876 3.95e-93 - - - K - - - helix_turn_helix multiple antibiotic resistance protein
MANCPEPA_03877 4.3e-255 yxnA - - IQ - - - Belongs to the short-chain dehydrogenases reductases (SDR) family
MANCPEPA_03878 3.91e-130 yxaF - - K ko:K18939 - ko00000,ko00002,ko03000 Transcriptional regulator
MANCPEPA_03879 1.05e-250 - 1.13.11.24 - S ko:K07155 - ko00000,ko01000 AraC-like ligand binding domain
MANCPEPA_03880 2.64e-286 - - - P ko:K07148 - ko00000 Protein of unknown function (DUF418)
MANCPEPA_03881 4.03e-99 yxaI - - S - - - membrane protein domain
MANCPEPA_03882 7.22e-79 - - - S - - - Family of unknown function (DUF5391)
MANCPEPA_03883 2.63e-137 yxaL - - S - - - PQQ-like domain
MANCPEPA_03884 2.09e-16 yxaI - - S - - - membrane protein domain
MANCPEPA_03885 2.4e-313 aldX 1.2.1.3 - C ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Belongs to the aldehyde dehydrogenase family
MANCPEPA_03886 1.03e-265 yxbF - - K - - - Bacterial regulatory proteins, tetR family
MANCPEPA_03887 8.38e-193 yxbG - - IQ - - - Enoyl-(Acyl carrier protein) reductase
MANCPEPA_03889 0.0 htpG - - O ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 Molecular chaperone. Has ATPase activity
MANCPEPA_03890 2.4e-312 csbC - - U ko:K02100,ko:K06609,ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MANCPEPA_03891 2.13e-64 yxcD - - S - - - Protein of unknown function (DUF2653)
MANCPEPA_03893 3.52e-224 iolS - - C ko:K06607 - ko00000,ko01000 Aldo keto reductase
MANCPEPA_03894 1.56e-177 iolR - - K ko:K06608,ko:K11534 - ko00000,ko03000 COG1349 Transcriptional regulators of sugar metabolism
MANCPEPA_03895 0.0 iolA 1.2.1.18, 1.2.1.27 - C ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MANCPEPA_03896 1.64e-198 iolB 5.3.1.30 - G ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 ko00000,ko00001,ko01000 Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
MANCPEPA_03897 1.75e-227 iolC 2.7.1.92 - G ko:K03338 ko00562,ko01100,ko01120,map00562,map01100,map01120 ko00000,ko00001,ko01000 Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
MANCPEPA_03898 0.0 iolD 3.7.1.22 - E ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 ko00000,ko00001,ko01000 Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
MANCPEPA_03899 7.09e-222 iolE 4.2.1.44 - G ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 ko00000,ko00001,ko01000 Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
MANCPEPA_03900 4.01e-296 iolF - - EGP ko:K06610 - ko00000,ko02000 Major facilitator superfamily
MANCPEPA_03901 4.44e-251 iolG 1.1.1.18, 1.1.1.369 - S ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 ko00000,ko00001,ko01000 Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
MANCPEPA_03902 1.08e-212 iolH - - G ko:K06605 - ko00000 Xylose isomerase-like TIM barrel
MANCPEPA_03903 3.79e-187 iolI 5.3.99.11 - G ko:K06606 ko00562,ko01120,map00562,map01120 ko00000,ko00001,ko01000 Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
MANCPEPA_03904 6.95e-205 fbaA 4.1.2.13, 4.1.2.29 - F ko:K01624,ko:K03339 ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
MANCPEPA_03905 3.27e-159 yxdJ - - T ko:K02483,ko:K11634 ko02020,map02020 ko00000,ko00001,ko00002,ko02022 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MANCPEPA_03906 1.1e-230 yxdK 2.7.13.3 - T ko:K11633 ko02020,map02020 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Histidine kinase
MANCPEPA_03907 9.39e-182 yxdL - - V ko:K11635 ko02020,map02020 ko00000,ko00001,ko00002,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_03908 0.0 yxdM - - V ko:K11636 ko02020,map02020 ko00000,ko00001,ko00002,ko02000 ABC transporter (permease)
MANCPEPA_03909 2.43e-76 yxeA - - S - - - Protein of unknown function (DUF1093)
MANCPEPA_03910 2.12e-226 fhuD - - P ko:K02016 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 ABC transporter
MANCPEPA_03911 6.79e-91 - - - - - - - -
MANCPEPA_03912 1.52e-27 yxeD - - - - - - -
MANCPEPA_03913 7.32e-42 yxeE - - - - - - -
MANCPEPA_03916 2.32e-193 yxeH - - S - - - hydrolases of the HAD superfamily
MANCPEPA_03917 5.12e-242 yxeI 3.5.1.24 - M ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 ko00000,ko00001,ko01000 Linear amide C-N hydrolases, choloylglycine hydrolase family
MANCPEPA_03919 0.0 yxeK - - C - - - COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANCPEPA_03920 5.16e-120 yxeL - - K - - - COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MANCPEPA_03921 4.3e-186 yxeM - - M ko:K16961 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the bacterial solute-binding protein 3 family
MANCPEPA_03922 3e-148 yxeN - - P ko:K10009,ko:K16962 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 COG0765 ABC-type amino acid transport system, permease component
MANCPEPA_03923 1.67e-171 yxeO - - P ko:K16960,ko:K16963 ko02010,map02010 ko00000,ko00001,ko00002,ko01000,ko02000 ABC transporter, ATP-binding protein
MANCPEPA_03924 4.58e-269 yxeP - - E ko:K21613 - ko00000,ko01000,ko01002 hydrolase activity
MANCPEPA_03925 3.42e-313 yxeQ - - S - - - MmgE/PrpD family
MANCPEPA_03926 1.01e-251 eutH - - E ko:K04023 - ko00000 Ethanolamine utilisation protein, EutH
MANCPEPA_03927 5.9e-194 - - - S - - - Domain of Unknown Function (DUF1206)
MANCPEPA_03928 1.22e-221 deoR - - K ko:K05346 - ko00000,ko03000 COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MANCPEPA_03929 3.38e-149 deoC 4.1.2.4 - F ko:K01619 ko00030,map00030 ko00000,ko00001,ko01000 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MANCPEPA_03930 1.92e-263 nupC - - F ko:K11535 - ko00000,ko02000 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MANCPEPA_03931 4.69e-298 pdp 2.4.2.2 - F ko:K00756 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko01000 phosphorylase
MANCPEPA_03932 0.0 ybgF - - E ko:K02205,ko:K16235,ko:K16236 - ko00000,ko02000 amino acid
MANCPEPA_03933 9e-227 hutG 3.5.3.8 - E ko:K01479 ko00340,ko01100,map00340,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
MANCPEPA_03934 4.51e-299 hutI 3.5.2.7 - Q ko:K01468 ko00340,ko01100,map00340,map01100 ko00000,ko00001,ko00002,ko01000 Imidazolone-5-propionate hydrolase
MANCPEPA_03935 0.0 hutU 4.2.1.49 - E ko:K01712 ko00340,ko01100,map00340,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MANCPEPA_03936 0.0 hutH 4.3.1.3 - E ko:K01745 ko00340,ko01100,map00340,map01100 ko00000,ko00001,ko00002,ko01000 Histidine ammonia-lyase
MANCPEPA_03937 7.02e-103 hutP - - K ko:K09683 - ko00000,ko03000 Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
MANCPEPA_03938 0.0 yxiA 3.2.1.99 GH43 G ko:K06113 - ko00000,ko01000 Belongs to the glycosyl hydrolase 43 family
MANCPEPA_03939 5.38e-37 - - - S - - - Domain of unknown function (DUF5082)
MANCPEPA_03940 1.89e-52 yxiC - - S - - - Family of unknown function (DUF5344)
MANCPEPA_03941 0.0 - - - S ko:K21493 - ko00000,ko01000,ko02048 nuclease activity
MANCPEPA_03942 9.25e-103 - - - S ko:K21494 - ko00000,ko02048 SMI1 / KNR4 family
MANCPEPA_03943 0.0 bglP - - G ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 ko00000,ko00001,ko00002,ko01000,ko02000 phosphotransferase system
MANCPEPA_03944 0.0 bglH 3.2.1.86 GT1 G ko:K01223 ko00010,ko00500,map00010,map00500 ko00000,ko00001,ko01000 Belongs to the glycosyl hydrolase 1 family
MANCPEPA_03945 2e-93 yxiE - - T - - - Belongs to the universal stress protein A family
MANCPEPA_03946 8.44e-210 yxxF - - EG - - - EamA-like transporter family
MANCPEPA_03947 0.0 wapA - - M - - - COG3209 Rhs family protein
MANCPEPA_03948 1.09e-94 yxxG - - - - - - -
MANCPEPA_03949 1.5e-110 - - - - - - - -
MANCPEPA_03950 3.49e-77 - - - - - - - -
MANCPEPA_03951 2.81e-90 yxiG - - - - - - -
MANCPEPA_03952 2.63e-177 - - - - - - - -
MANCPEPA_03953 1.27e-105 yxiI - - S - - - Protein of unknown function (DUF2716)
MANCPEPA_03954 5.34e-54 yxiJ - - S - - - YxiJ-like protein
MANCPEPA_03957 4.59e-270 - - - E - - - GDSL-like Lipase/Acylhydrolase
MANCPEPA_03958 0.0 dbpA 3.6.4.13 - JKL ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
MANCPEPA_03959 3.8e-292 yxiO - - S ko:K06902 ko04138,map04138 ko00000,ko00001,ko02000,ko04131 COG2270 Permeases of the major facilitator superfamily
MANCPEPA_03960 5.32e-143 - - - - - - - -
MANCPEPA_03961 5.66e-193 licT - - K ko:K03488 - ko00000,ko03000 transcriptional antiterminator
MANCPEPA_03962 1.77e-183 bglS - - M - - - licheninase activity
MANCPEPA_03963 2e-284 citH - - C ko:K03300,ko:K11639 ko02020,map02020 ko00000,ko00001 Citrate transporter
MANCPEPA_03964 0.0 katE 1.11.1.6 - P ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 ko00000,ko00001,ko00002,ko01000 serves to protect cells from the toxic effects of hydrogen peroxide
MANCPEPA_03965 6.54e-63 yxiS - - - - - - -
MANCPEPA_03966 1.4e-131 - - - T - - - Domain of unknown function (DUF4163)
MANCPEPA_03967 1.21e-268 nupG - - F ko:K16323 - ko00000,ko02000 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MANCPEPA_03968 3.44e-201 yxjB 2.1.1.187 - Q ko:K00563 - ko00000,ko01000,ko03009 Methyltransferase domain
MANCPEPA_03969 0.0 yxjC - - EG - - - COG2610 H gluconate symporter and related permeases
MANCPEPA_03970 3.82e-167 scoA 2.8.3.5 - I ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 ko00000,ko00001,ko01000 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MANCPEPA_03971 2.41e-150 scoB 2.8.3.5 - I ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 ko00000,ko00001,ko01000 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MANCPEPA_03972 2.77e-174 yxjF 1.1.1.30 - IQ ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MANCPEPA_03973 1.55e-275 yxjG 2.1.1.14 - E ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Methionine synthase
MANCPEPA_03974 3.02e-277 yxjG 2.1.1.14 - E ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko00000,ko00001,ko00002,ko01000 Methionine synthase
MANCPEPA_03975 9.66e-110 yxjI - - S - - - LURP-one-related
MANCPEPA_03978 4.49e-298 pepT 3.4.11.4 - E ko:K01258 - ko00000,ko01000,ko01002 Cleaves the N-terminal amino acid of tripeptides
MANCPEPA_03979 7.4e-146 - - - K ko:K02479 - ko00000,ko02022 helix_turn_helix, Lux Regulon
MANCPEPA_03980 6.51e-257 - - - T - - - Signal transduction histidine kinase
MANCPEPA_03981 3.81e-100 - - - S - - - Protein of unknown function (DUF1453)
MANCPEPA_03982 8.6e-249 galE 5.1.3.2 - M ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 ko00000,ko00001,ko00002,ko01000 Belongs to the NAD(P)-dependent epimerase dehydratase family
MANCPEPA_03983 6.41e-181 - - - - - - - -
MANCPEPA_03984 2.29e-188 yxkD - - S - - - Uncharacterised 5xTM membrane BCR, YitT family COG1284
MANCPEPA_03985 0.0 aldY 1.2.1.3, 1.2.1.67 - C ko:K00128,ko:K21802 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MANCPEPA_03986 2.74e-210 lrp - - QT - - - PucR C-terminal helix-turn-helix domain
MANCPEPA_03987 3.44e-261 msmX - - P ko:K10112 ko02010,map02010 ko00000,ko00001,ko00002,ko02000 Belongs to the ABC transporter superfamily
MANCPEPA_03988 1.77e-197 yxkH - - G - - - Polysaccharide deacetylase
MANCPEPA_03990 0.0 - - - O - - - Peptidase family M48
MANCPEPA_03991 2.67e-308 cimH - - C - - - COG3493 Na citrate symporter
MANCPEPA_03992 0.0 cydA 1.10.3.14 - C ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 ko00000,ko00001,ko00002,ko01000 oxidase, subunit
MANCPEPA_03993 1.16e-243 cydB 1.10.3.14 - C ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 ko00000,ko00001,ko00002,ko01000 Cytochrome d ubiquinol oxidase, subunit II
MANCPEPA_03994 0.0 lysS 6.1.1.6 - J ko:K04567 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Belongs to the class-II aminoacyl-tRNA synthetase family
MANCPEPA_03995 1.59e-243 dus - - J ko:K05540 - ko00000,ko01000,ko03016 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MANCPEPA_03996 1.81e-41 yazB - - K - - - transcriptional
MANCPEPA_03997 2.64e-114 folK 2.7.6.3 - H ko:K00950 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MANCPEPA_03998 3.8e-80 folB 1.13.11.81, 4.1.2.25, 5.1.99.8 - H ko:K01633 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MANCPEPA_03999 1.3e-202 folP 2.5.1.15 - H ko:K00796 ko00790,ko01100,map00790,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MANCPEPA_04000 4.4e-214 pabC 4.1.3.38 - EH ko:K02619 ko00790,map00790 ko00000,ko00001,ko01000 4-amino-4-deoxychorismate lyase
MANCPEPA_04001 1.72e-136 pabA 2.6.1.85 - EH ko:K01664 ko00790,map00790 ko00000,ko00001,ko01000 Anthranilate synthase
MANCPEPA_04002 0.0 pabB 2.6.1.85 - EH ko:K01665 ko00790,map00790 ko00000,ko00001,ko01000 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MANCPEPA_04003 1.54e-217 cysK 2.5.1.47 - E ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Belongs to the cysteine synthase cystathionine beta- synthase family
MANCPEPA_04004 8.07e-203 yacD 5.2.1.8 - O ko:K07533 - ko00000,ko01000,ko03110 peptidyl-prolyl isomerase
MANCPEPA_04005 9.54e-208 hslO - - O ko:K04083 - ko00000,ko03110 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MANCPEPA_04006 6.92e-189 coaX 2.7.1.33 - F ko:K03525 ko00770,ko01100,map00770,map01100 ko00000,ko00001,ko00002,ko01000 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MANCPEPA_04007 0.0 ftsH - - O ko:K03798 - ko00000,ko00002,ko01000,ko01002,ko03110 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MANCPEPA_04008 4.82e-121 hpt 2.4.2.8, 6.3.4.19 - F ko:K00760,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko00000,ko00001,ko01000,ko03016 Belongs to the purine pyrimidine phosphoribosyltransferase family
MANCPEPA_04009 0.0 tilS 2.4.2.8, 6.3.4.19 - D ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 ko00000,ko00001,ko01000,ko03016 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MANCPEPA_04010 6.92e-236 yabT 2.7.11.1 - KLT ko:K08884 - ko00000,ko01000,ko01001 serine threonine protein kinase
MANCPEPA_04011 5.61e-168 yabS - - S ko:K07114 - ko00000,ko02000 protein containing a von Willebrand factor type A (vWA) domain
MANCPEPA_04012 0.0 spoIIE 3.1.3.16 - KT ko:K06382 - ko00000,ko01000 stage II sporulation protein E
MANCPEPA_04015 2.49e-82 yabR - - J ko:K07571 - ko00000 RNA binding protein (contains ribosomal protein S1 domain)
MANCPEPA_04016 4.18e-75 divIC - - D ko:K13052 - ko00000,ko03036 Septum formation initiator
MANCPEPA_04017 5.21e-138 yabQ - - S - - - spore cortex biosynthesis protein
MANCPEPA_04018 1.91e-66 yabP - - S - - - Sporulation protein YabP
MANCPEPA_04019 4.22e-50 yabO - - J - - - COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
MANCPEPA_04020 0.0 yabN 3.6.1.66 - S ko:K02428,ko:K02499 ko00230,map00230 ko00000,ko00001,ko01000,ko03036 COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
MANCPEPA_04021 0.0 yabM - - S ko:K03328 - ko00000 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MANCPEPA_04022 5.88e-121 spoVT - - K ko:K04769 - ko00000,ko03000 stage V sporulation protein
MANCPEPA_04023 0.0 mfd - - L ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MANCPEPA_04024 6.36e-54 yabK - - S - - - Peptide ABC transporter permease
MANCPEPA_04025 2.03e-135 pth 3.1.1.29 - J ko:K01056 - ko00000,ko01000,ko03012 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MANCPEPA_04026 1.45e-136 ctc - - J ko:K02897 ko03010,map03010 ko00000,ko00001,ko00002,ko03011 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MANCPEPA_04027 1.22e-223 prs 2.7.6.1 - F ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 ko00000,ko00001,ko00002,ko01000 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MANCPEPA_04028 1.49e-308 glmU 2.3.1.157, 2.7.7.23 - M ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 ko00000,ko00001,ko00002,ko01000 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MANCPEPA_04029 2.45e-63 spoVG - - D ko:K06412 - ko00000 Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
MANCPEPA_04030 1.4e-82 yabJ 3.5.99.10 - J ko:K09022 - ko00000,ko01000 translation initiation inhibitor, yjgF family
MANCPEPA_04031 4.66e-196 purR - - F ko:K09685 - ko00000,ko03000 pur operon repressor
MANCPEPA_04032 2.34e-207 ispE 2.7.1.148 - I ko:K00919,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko00000,ko00001,ko00002,ko01000,ko02000 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MANCPEPA_04033 5.32e-53 veg - - S - - - protein conserved in bacteria
MANCPEPA_04034 1.84e-197 yabG - - S ko:K06436 - ko00000 peptidase
MANCPEPA_04035 8.34e-198 ksgA 2.1.1.182 - J ko:K02528 - ko00000,ko01000,ko03009 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MANCPEPA_04036 1.43e-125 rnmV 3.1.26.8 - J ko:K05985 - ko00000,ko01000 Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MANCPEPA_04037 4.1e-278 yabE - - T - - - protein conserved in bacteria
MANCPEPA_04038 4.85e-183 tatD - - L ko:K03424 - ko00000,ko01000 hydrolase, TatD
MANCPEPA_04039 0.0 metG 6.1.1.10 - J ko:K01874 ko00450,ko00970,map00450,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MANCPEPA_04040 1.51e-58 abrB - - K ko:K06284 - ko00000,ko03000 COG2002 Regulators of stationary sporulation gene expression
MANCPEPA_04041 2.95e-207 rsmI 2.1.1.198 - H ko:K07056 - ko00000,ko01000,ko03009 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MANCPEPA_04042 4.19e-65 yazA - - L ko:K07461 - ko00000 endonuclease containing a URI domain
MANCPEPA_04043 2.81e-178 yabB 2.1.1.223 - S ko:K07461,ko:K15460 - ko00000,ko01000,ko03016 Conserved hypothetical protein 95
MANCPEPA_04044 1.53e-56 yabA - - L - - - Involved in initiation control of chromosome replication
MANCPEPA_04045 1.1e-189 yaaT - - S - - - stage 0 sporulation protein
MANCPEPA_04046 2.42e-236 holB 2.7.7.7 - L ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 DNA polymerase III
MANCPEPA_04047 1.26e-95 yaaR - - S ko:K09770 - ko00000 protein conserved in bacteria
MANCPEPA_04048 1.02e-72 yaaQ - - S - - - protein conserved in bacteria
MANCPEPA_04049 9.43e-146 tmk 2.7.4.9 - F ko:K00943 ko00240,ko01100,map00240,map01100 ko00000,ko00001,ko00002,ko01000 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MANCPEPA_04050 0.0 yaaO - - E - - - Orn Lys Arg decarboxylase
MANCPEPA_04051 1.02e-259 yaaN - - P - - - Belongs to the TelA family
MANCPEPA_04052 2.7e-132 xpaC - - S - - - 5-bromo-4-chloroindolyl phosphate hydrolysis protein
MANCPEPA_04053 2.21e-42 csfB - - S - - - Inhibitor of sigma-G Gin
MANCPEPA_04054 2.16e-48 bofA - - S ko:K06317 - ko00000 Sigma-K factor-processing regulatory protein BofA
MANCPEPA_04055 1.55e-42 yaaL - - S - - - Protein of unknown function (DUF2508)
MANCPEPA_04056 8.53e-142 recR - - L ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MANCPEPA_04057 8.75e-55 yaaK - - S ko:K09747 - ko00000 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MANCPEPA_04058 0.0 dnaX 2.7.7.7 - L ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MANCPEPA_04059 6.05e-108 tadA 3.5.4.33 - FJ ko:K11991 - ko00000,ko01000,ko03016 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MANCPEPA_04060 5.64e-125 yaaI - - Q - - - COG1335 Amidases related to nicotinamidase
MANCPEPA_04061 2.99e-275 yaaH - - M ko:K06306 - ko00000 Glycoside Hydrolase Family
MANCPEPA_04062 5.73e-149 dgk 2.7.1.113 - F ko:K15518 ko00230,map00230 ko00000,ko00001,ko01000 Deoxyguanosine kinase
MANCPEPA_04063 3.72e-159 dck 2.7.1.74, 2.7.1.76 - F ko:K15519 ko00230,ko00240,ko01100,map00230,map00240,map01100 ko00000,ko00001,ko01000 Deoxycytidine kinase
MANCPEPA_04065 9.79e-296 serS 6.1.1.11 - J ko:K01875 ko00970,map00970 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MANCPEPA_04066 1.66e-138 pdxT 4.3.3.6 - H ko:K08681 ko00750,map00750 ko00000,ko00001,ko01000 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MANCPEPA_04067 3.7e-202 pdxS 4.3.3.6 - H ko:K06215 ko00750,map00750 ko00000,ko00001,ko01000 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MANCPEPA_04068 1.03e-315 dacA 3.4.16.4 - M ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Belongs to the peptidase S11 family
MANCPEPA_04069 0.0 guaB 1.1.1.205 - F ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko00000,ko00001,ko00002,ko01000,ko04147 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MANCPEPA_04070 2.6e-233 yaaC - - S - - - YaaC-like Protein

eggNOG-mapper v2.1.12 (Database: eggNOG v5.0.2, Mar. 2021 release)