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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
MKMBIGCO_00003	0.0	yflS	-	-	P	ko:K03319	-	ko00000	Sodium:sulfate symporter transmembrane region
MKMBIGCO_00004	1.87e-307	pel	4.2.2.2	-	G	ko:K01728	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectate lyase
MKMBIGCO_00005	4.9e-76	yflT	-	-	S	-	-	-	Heat induced stress protein YflT
MKMBIGCO_00006	2.1e-31	-	-	-	S	-	-	-	Protein of unknown function (DUF3212)
MKMBIGCO_00007	1.35e-238	yfmJ	-	-	S	ko:K07119	-	ko00000	N-terminal domain of oxidoreductase
MKMBIGCO_00008	2.7e-82	yfmK	2.3.1.128	-	K	ko:K03790	-	ko00000,ko01000,ko03009	acetyltransferase
MKMBIGCO_00009	4.02e-261	yfmL	-	-	L	-	-	-	COG0513 Superfamily II DNA and RNA helicases
MKMBIGCO_00010	0.0	yheS_1	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MKMBIGCO_00011	1.39e-261	yfmO	-	-	EGP	ko:K08221	-	ko00000,ko02000	Major facilitator superfamily
MKMBIGCO_00012	8.7e-91	yfmP	-	-	K	ko:K21902	-	ko00000,ko03000	transcriptional
MKMBIGCO_00013	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MKMBIGCO_00014	2.43e-265	-	-	-	M	-	-	-	COG0463 Glycosyltransferases involved in cell wall biogenesis
MKMBIGCO_00015	3.48e-214	yhxD	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MKMBIGCO_00016	2.04e-162	yfmS	-	-	NT	-	-	-	chemotaxis protein
MKMBIGCO_00017	0.0	yfmT	1.2.1.3, 1.2.1.67	-	C	ko:K00128,ko:K21802	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MKMBIGCO_00018	2.4e-312	yfnA	-	-	E	ko:K03294	-	ko00000	amino acid
MKMBIGCO_00019	6.35e-277	fsr	-	-	P	ko:K08223	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_00020	8.13e-238	yfnD	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
MKMBIGCO_00021	2.22e-279	yfnE	-	-	S	-	-	-	Glycosyltransferase like family 2
MKMBIGCO_00022	6.61e-230	yfnF	-	-	M	-	-	-	Nucleotide-diphospho-sugar transferase
MKMBIGCO_00023	3.93e-219	yfnG	4.2.1.45, 4.2.1.46	-	M	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	dehydratase
MKMBIGCO_00024	1.02e-188	yfnH	2.7.7.33	-	JM	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	ko00000,ko00001,ko01000	Nucleotidyl transferase
MKMBIGCO_00025	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
MKMBIGCO_00026	1.27e-185	-	2.1.1.163, 2.1.1.201	-	Q	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	methyltransferase
MKMBIGCO_00027	1.68e-146	-	-	-	S	-	-	-	CAAX protease self-immunity
MKMBIGCO_00028	1.29e-194	-	-	-	C	-	-	-	Nitroreductase family
MKMBIGCO_00029	0.0	-	-	-	S	ko:K09136	-	ko00000,ko03009	YcaO cyclodehydratase, ATP-ad Mg2+-binding
MKMBIGCO_00030	2.06e-233	-	-	-	S	-	-	-	ATP diphosphatase activity
MKMBIGCO_00031	5.22e-163	-	-	-	-	-	-	-	-
MKMBIGCO_00032	4.52e-100	-	-	-	S	-	-	-	protein homooligomerization
MKMBIGCO_00033	7.58e-162	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MKMBIGCO_00034	5.72e-207	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MKMBIGCO_00035	5.83e-67	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MKMBIGCO_00037	0.0	cypD	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
MKMBIGCO_00038	2.38e-252	yetN	-	-	S	-	-	-	Protein of unknown function (DUF3900)
MKMBIGCO_00039	3.88e-261	yetM	-	-	CH	-	-	-	FAD binding domain
MKMBIGCO_00040	1.92e-113	yetL	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_00041	7.32e-135	yetJ	-	-	S	ko:K06890	-	ko00000	Belongs to the BI1 family
MKMBIGCO_00042	3.68e-73	-	-	-	H	-	-	-	riboflavin kinase activity
MKMBIGCO_00043	1.34e-31	-	-	-	S	-	-	-	Uncharacterized small protein (DUF2292)
MKMBIGCO_00044	6.02e-195	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MKMBIGCO_00045	2.66e-85	yetH	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MKMBIGCO_00046	1.11e-72	yetG	1.14.99.48	-	S	ko:K07145	ko00860,ko01110,map00860,map01110	ko00000,ko00001,ko01000	Antibiotic biosynthesis monooxygenase
MKMBIGCO_00047	2.12e-155	yetF	-	-	S	-	-	-	membrane
MKMBIGCO_00048	0.000118	-	-	-	-	-	-	-	-
MKMBIGCO_00049	4.48e-120	yesJ	-	-	K	-	-	-	Acetyltransferase (GNAT) family
MKMBIGCO_00050	1.48e-133	cotJC	-	-	P	ko:K06334	-	ko00000	Spore Coat
MKMBIGCO_00051	1.62e-61	cotJB	-	-	S	ko:K06333	-	ko00000	CotJB protein
MKMBIGCO_00052	2.67e-60	cotJA	-	-	S	ko:K06332	-	ko00000	Spore coat associated protein JA (CotJA)
MKMBIGCO_00053	9.27e-137	aadK	-	-	G	ko:K05593	-	ko00000,ko01000,ko01504	Streptomycin adenylyltransferase
MKMBIGCO_00055	3.12e-162	yeeN	-	-	K	-	-	-	transcriptional regulatory protein
MKMBIGCO_00056	1.43e-67	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MKMBIGCO_00057	1.62e-78	-	-	-	S	-	-	-	Protein of unknown function, DUF600
MKMBIGCO_00058	1.37e-175	cylB	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
MKMBIGCO_00059	9.62e-203	cylA	-	-	V	ko:K01990,ko:K09695,ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
MKMBIGCO_00060	5.22e-144	-	1.1.1.100	-	IQ	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
MKMBIGCO_00061	1.01e-168	-	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	3-oxoacyl-[acyl-carrier-protein] synthase activity
MKMBIGCO_00062	1.25e-246	-	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MKMBIGCO_00063	4.7e-82	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKMBIGCO_00064	1.27e-44	-	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKMBIGCO_00066	8.44e-102	vraR	-	-	KT	ko:K07694,ko:K11624	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_00067	0.0	rlmCD	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MKMBIGCO_00068	5.16e-218	dagK	2.7.1.107	-	I	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MKMBIGCO_00069	0.0	swrC	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKMBIGCO_00070	5.24e-196	yerO	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00071	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKMBIGCO_00072	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
MKMBIGCO_00073	1.81e-60	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKMBIGCO_00074	0.0	putP	-	-	E	ko:K03307,ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKMBIGCO_00075	1.68e-157	sapB	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
MKMBIGCO_00076	3.34e-244	yerI	-	-	S	-	-	-	homoserine kinase type II (protein kinase fold)
MKMBIGCO_00077	6.46e-285	camS	-	-	S	-	-	-	COG4851 Protein involved in sex pheromone biosynthesis
MKMBIGCO_00078	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKMBIGCO_00079	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
MKMBIGCO_00080	8.71e-164	pcrB	-	-	I	ko:K07094	-	ko00000,ko01000	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MKMBIGCO_00081	0.0	yerD	1.4.7.1	-	E	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	ko00000,ko00001,ko01000	Belongs to the glutamate synthase family
MKMBIGCO_00082	2.03e-67	yerC	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00083	6.02e-247	yerB	-	-	S	-	-	-	Protein of unknown function (DUF3048) C-terminal domain
MKMBIGCO_00084	0.0	yerA	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	adenine deaminase
MKMBIGCO_00085	1.2e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF2892)
MKMBIGCO_00086	3.29e-297	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
MKMBIGCO_00087	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
MKMBIGCO_00088	9.96e-135	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MKMBIGCO_00089	1.46e-241	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
MKMBIGCO_00090	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MKMBIGCO_00091	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKMBIGCO_00092	9.46e-167	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKMBIGCO_00093	3.79e-52	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKMBIGCO_00094	3.96e-165	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
MKMBIGCO_00095	6.38e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKMBIGCO_00096	3.74e-286	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MKMBIGCO_00097	3.78e-107	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MKMBIGCO_00098	6.56e-40	yebG	-	-	S	-	-	-	NETI protein
MKMBIGCO_00099	1.21e-118	yebE	-	-	S	-	-	-	UPF0316 protein
MKMBIGCO_00101	6.19e-168	yebC	-	-	M	-	-	-	Membrane
MKMBIGCO_00102	1.75e-269	pbuG	-	-	S	ko:K06901	-	ko00000,ko02000	permease
MKMBIGCO_00103	1.51e-313	-	-	-	S	-	-	-	Domain of unknown function (DUF4179)
MKMBIGCO_00104	1.34e-121	-	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_00105	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
MKMBIGCO_00106	0.0	yebA	-	-	E	-	-	-	COG1305 Transglutaminase-like enzymes
MKMBIGCO_00107	7.2e-265	yeaD	-	-	S	-	-	-	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
MKMBIGCO_00108	2.29e-225	yeaC	-	-	S	ko:K03924	-	ko00000,ko01000	COG0714 MoxR-like ATPases
MKMBIGCO_00109	4.33e-315	gabP	-	-	E	ko:K11735	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_00110	0.0	cotA	1.16.3.3	-	Q	ko:K06324	-	ko00000,ko01000	multicopper oxidases
MKMBIGCO_00111	2.02e-47	ydjO	-	-	S	-	-	-	Cold-inducible protein YdjO
MKMBIGCO_00113	1.36e-192	ydjN	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
MKMBIGCO_00114	6.51e-82	ydjM	-	-	M	-	-	-	Lytic transglycolase
MKMBIGCO_00115	8.25e-248	ydjL	1.1.1.264, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00098	ko00650,map00650	ko00000,ko00001,ko01000	Dehydrogenase
MKMBIGCO_00116	1.87e-113	sigV	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_00117	4.82e-194	rsiV	-	-	S	-	-	-	Protein of unknown function (DUF3298)
MKMBIGCO_00118	0.0	oatA	-	-	I	-	-	-	Acyltransferase family
MKMBIGCO_00119	2.8e-201	ydjI	-	-	S	-	-	-	virion core protein (lumpy skin disease virus)
MKMBIGCO_00120	8.73e-160	ydjH	-	-	S	ko:K06872	-	ko00000	COG1512 Beta-propeller domains of methanol dehydrogenase type
MKMBIGCO_00121	1.55e-229	ydjG	-	-	L	-	-	-	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKMBIGCO_00122	3.9e-146	pspA	-	-	KT	ko:K03969	-	ko00000	Phage shock protein A
MKMBIGCO_00123	1.47e-40	yjdJ	-	-	S	-	-	-	Domain of unknown function (DUF4306)
MKMBIGCO_00124	1.42e-219	ydjE	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
MKMBIGCO_00125	1.18e-315	gutP	-	-	G	ko:K03292,ko:K16248	-	ko00000,ko02000	MFS/sugar transport protein
MKMBIGCO_00126	2.05e-256	gutB	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
MKMBIGCO_00127	0.0	gutR	-	-	K	ko:K16247	-	ko00000,ko03000	NB-ARC domain
MKMBIGCO_00128	7.07e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF4064)
MKMBIGCO_00129	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
MKMBIGCO_00130	2.14e-58	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MKMBIGCO_00131	1.67e-164	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
MKMBIGCO_00132	1.11e-37	ydiK	-	-	S	-	-	-	Domain of unknown function (DUF4305)
MKMBIGCO_00133	1.92e-161	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKMBIGCO_00134	1.72e-29	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MKMBIGCO_00135	1.29e-149	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MKMBIGCO_00136	2.95e-117	moaC	4.6.1.17	-	H	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
MKMBIGCO_00137	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
MKMBIGCO_00138	1.26e-242	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MKMBIGCO_00139	1.41e-108	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
MKMBIGCO_00140	2.8e-160	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	COG1214 Inactive homolog of metal-dependent proteases
MKMBIGCO_00141	7.42e-112	ydiB	-	-	S	ko:K06925	-	ko00000,ko03016	ATPase or kinase
MKMBIGCO_00142	4.87e-234	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MKMBIGCO_00144	6.72e-55	ydbB	-	-	G	-	-	-	Cupin domain
MKMBIGCO_00145	2.39e-78	ydbC	-	-	S	-	-	-	Domain of unknown function (DUF4937
MKMBIGCO_00146	7.8e-198	ydbD	-	-	P	ko:K07217	-	ko00000	Catalase
MKMBIGCO_00147	4.46e-254	dctB	-	-	G	-	-	-	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
MKMBIGCO_00148	0.0	dctS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MKMBIGCO_00149	3.67e-153	dctR	-	-	T	ko:K02475,ko:K11692	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
MKMBIGCO_00150	1.12e-286	dctA	-	-	U	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MKMBIGCO_00151	1.22e-230	ydbI	-	-	S	-	-	-	AI-2E family transporter
MKMBIGCO_00152	7.61e-218	ydbJ	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_00153	9.93e-167	ydbK	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MKMBIGCO_00154	1.32e-69	ydbL	-	-	-	-	-	-	-
MKMBIGCO_00155	2.98e-260	ydbM	-	-	I	-	-	-	acyl-CoA dehydrogenase
MKMBIGCO_00156	1.13e-15	-	-	-	S	-	-	-	Fur-regulated basic protein B
MKMBIGCO_00157	6.58e-14	-	-	-	S	-	-	-	Fur-regulated basic protein A
MKMBIGCO_00158	1.91e-158	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKMBIGCO_00159	2.25e-74	ydbP	-	-	CO	-	-	-	Thioredoxin
MKMBIGCO_00160	2.52e-257	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
MKMBIGCO_00161	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
MKMBIGCO_00162	0.0	cshA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
MKMBIGCO_00163	2.18e-96	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
MKMBIGCO_00164	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Membrane
MKMBIGCO_00165	2.08e-138	ydcA	-	-	S	-	-	-	membrane protein (homolog of Drosophila rhomboid)
MKMBIGCO_00166	1.54e-75	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
MKMBIGCO_00167	6.39e-235	ydcC	-	-	M	-	-	-	COG2834 Outer membrane lipoprotein-sorting protein
MKMBIGCO_00168	1.63e-278	alr	5.1.1.1, 5.1.1.5	-	E	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKMBIGCO_00169	6.68e-57	ndoAI	-	-	K	ko:K07723	-	ko00000,ko02048,ko03000	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain
MKMBIGCO_00170	4.34e-75	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
MKMBIGCO_00171	1.05e-186	rsbR	-	-	T	ko:K17763	-	ko00000,ko03021	Positive regulator of sigma-B
MKMBIGCO_00172	1.09e-75	rsbS	-	-	T	ko:K17762	-	ko00000,ko03021	antagonist
MKMBIGCO_00173	1.73e-89	rsbT	2.7.11.1	-	T	ko:K17752	-	ko00000,ko01000,ko01001,ko03021	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)
MKMBIGCO_00174	1.78e-241	rsbU	3.1.3.3	-	KT	ko:K07315	-	ko00000,ko01000,ko03021	phosphatase
MKMBIGCO_00175	9.77e-71	rsbV	-	-	T	ko:K04749	-	ko00000,ko03021	Belongs to the anti-sigma-factor antagonist family
MKMBIGCO_00176	5.84e-110	rsbW	2.7.11.1	-	F	ko:K04757	-	ko00000,ko01000,ko01001,ko03021	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)
MKMBIGCO_00177	1.14e-180	sigB	-	-	K	ko:K03090	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_00178	2.74e-139	rsbX	3.1.3.3	-	KT	ko:K05518	-	ko00000,ko01000,ko03021	Sigma factor PP2C-like phosphatases
MKMBIGCO_00179	0.0	tex	-	-	K	ko:K06959	-	ko00000	COG2183 Transcriptional accessory protein
MKMBIGCO_00180	1.78e-21	-	-	-	-	-	-	-	-
MKMBIGCO_00181	1.74e-75	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
MKMBIGCO_00189	7.8e-124	yrkL	-	-	S	ko:K11748	-	ko00000,ko02000	Flavodoxin-like fold
MKMBIGCO_00190	1.14e-190	-	-	-	S	-	-	-	Serine aminopeptidase, S33
MKMBIGCO_00191	0.0	-	-	-	EGP	ko:K03761,ko:K03762	-	ko00000,ko02000	Transporter
MKMBIGCO_00192	3.7e-174	-	-	-	I	ko:K01066	-	ko00000,ko01000	esterase
MKMBIGCO_00193	2.29e-60	ohrB	-	-	O	-	-	-	OsmC-like protein
MKMBIGCO_00194	3.16e-64	ohrR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00195	4.42e-84	ywnA	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00196	5.24e-143	ywnB	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
MKMBIGCO_00197	3.87e-42	cspL	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock
MKMBIGCO_00198	2.63e-53	yrkD	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00199	1.38e-108	yrkE	-	-	O	-	-	-	DsrE/DsrF/DrsH-like family
MKMBIGCO_00200	9.11e-24	-	-	-	P	-	-	-	Rhodanese Homology Domain
MKMBIGCO_00201	1.8e-129	yrkF	-	-	OP	-	-	-	Belongs to the sulfur carrier protein TusA family
MKMBIGCO_00202	1.23e-255	yrkH	-	-	P	-	-	-	Rhodanese Homology Domain
MKMBIGCO_00203	6.46e-49	yrkI	-	-	O	-	-	-	Belongs to the sulfur carrier protein TusA family
MKMBIGCO_00204	2.82e-163	yrkJ	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MKMBIGCO_00205	1.27e-150	racX	5.1.1.13	-	M	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
MKMBIGCO_00206	8.25e-131	-	-	-	S	-	-	-	Protein of unknown function (DUF2812)
MKMBIGCO_00207	7.89e-66	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
MKMBIGCO_00208	2.92e-231	-	-	-	S	-	-	-	Patatin-like phospholipase
MKMBIGCO_00209	5.87e-109	-	-	-	S	-	-	-	DinB superfamily
MKMBIGCO_00210	1.58e-144	dpaL	4.3.1.15	-	E	ko:K01751	-	ko00000,ko01000	Pyridoxal-phosphate dependent enzyme
MKMBIGCO_00211	6.58e-86	-	-	-	K	-	-	-	COG1802 Transcriptional regulators
MKMBIGCO_00212	4.46e-52	-	-	-	J	-	-	-	Endoribonuclease L-PSP
MKMBIGCO_00213	8.01e-177	-	-	-	E	ko:K03837	-	ko00000,ko02000	Serine transporter
MKMBIGCO_00214	2.48e-205	-	-	-	E	-	-	-	Peptidase dimerisation domain
MKMBIGCO_00215	2.32e-160	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
MKMBIGCO_00216	6.65e-220	-	3.5.1.6, 3.5.1.87	-	E	ko:K06016	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MKMBIGCO_00217	1.01e-295	-	-	-	K	-	-	-	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MKMBIGCO_00218	1.25e-241	ydeG	-	-	EGP	-	-	-	Major facilitator superfamily
MKMBIGCO_00219	6.45e-38	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MKMBIGCO_00222	0.0	yvdP	-	-	C	-	-	-	COG0277 FAD FMN-containing dehydrogenases
MKMBIGCO_00223	1.36e-216	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	COG1230 Co Zn Cd efflux system component
MKMBIGCO_00224	2.66e-248	trkA	-	-	P	ko:K07222	-	ko00000	Oxidoreductase
MKMBIGCO_00227	1.3e-08	ykkA	-	-	S	-	-	-	Protein of unknown function (DUF664)
MKMBIGCO_00228	5.69e-191	dapA7	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
MKMBIGCO_00230	1.09e-249	cfr	2.1.1.224	-	J	ko:K15632	-	ko00000,ko01000,ko01504,ko03009	Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics
MKMBIGCO_00231	2.4e-68	ydeH	-	-	-	-	-	-	-
MKMBIGCO_00232	8.41e-212	-	-	-	S	-	-	-	Sodium Bile acid symporter family
MKMBIGCO_00233	1.06e-256	adhA	-	-	C	ko:K13979	-	ko00000,ko01000	alcohol dehydrogenase
MKMBIGCO_00234	1.21e-85	adhR	-	-	K	ko:K21745	-	ko00000,ko03000	helix_turn_helix, mercury resistance
MKMBIGCO_00235	4.37e-285	nhaC_1	-	-	C	-	-	-	antiporter
MKMBIGCO_00236	0.0	-	-	-	K	ko:K00375	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
MKMBIGCO_00237	1.03e-146	paiB	-	-	K	ko:K07734	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_00239	5.9e-248	ydeR	-	-	EGP	-	-	-	Uncharacterised MFS-type transporter YbfB
MKMBIGCO_00240	4.7e-130	ydeS	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00241	3.45e-64	yraD	-	-	M	ko:K06439	-	ko00000	Spore coat protein
MKMBIGCO_00242	4.86e-33	yraE	-	-	-	ko:K06440	-	ko00000	-
MKMBIGCO_00243	3.41e-279	adhB	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MKMBIGCO_00244	4.76e-84	yraF	-	-	M	-	-	-	Spore coat protein
MKMBIGCO_00245	9.9e-49	yraG	-	-	-	ko:K06440	-	ko00000	-
MKMBIGCO_00246	1.72e-275	ydfH	2.7.13.3	-	T	ko:K11623	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_00247	3.82e-140	ydfI	-	-	K	ko:K11624	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_00248	0.0	ydfJ	-	-	S	ko:K06994,ko:K11625	ko02020,map02020	ko00000,ko00001	drug exporters of the RND superfamily
MKMBIGCO_00249	3.98e-170	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	Peptidase C26
MKMBIGCO_00250	0.0	expZ	-	-	S	ko:K18231	ko02010,map02010	br01600,ko00000,ko00001,ko01504,ko02000	ABC transporter
MKMBIGCO_00251	5.07e-125	ynaD	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_00252	6.07e-192	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_00253	6.59e-249	gldA	1.1.1.6	-	C	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	ko00000,ko00001,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
MKMBIGCO_00254	3.34e-269	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
MKMBIGCO_00255	3.22e-287	fabF_1	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MKMBIGCO_00256	1.84e-199	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MKMBIGCO_00257	2.03e-154	ydhB	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MKMBIGCO_00258	7.23e-107	bltD	2.3.1.57	-	K	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	FR47-like protein
MKMBIGCO_00259	1.39e-191	bltR	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MKMBIGCO_00260	5.16e-191	gmT1	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MKMBIGCO_00261	9.15e-145	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
MKMBIGCO_00262	1.83e-185	-	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
MKMBIGCO_00263	5.06e-211	ycsA	1.1.1.83, 1.1.1.93, 4.1.1.73	-	CE	ko:K07246	ko00630,ko00650,map00630,map00650	ko00000,ko00001,ko01000	Isocitrate/isopropylmalate dehydrogenase
MKMBIGCO_00264	7.66e-153	ydhC	-	-	K	-	-	-	FCD
MKMBIGCO_00265	4.58e-289	ydhE	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MKMBIGCO_00268	0.0	pbpE	-	-	V	-	-	-	Beta-lactamase
MKMBIGCO_00270	6.11e-128	ydhK	-	-	M	-	-	-	Protein of unknown function (DUF1541)
MKMBIGCO_00271	2.24e-247	ydhL	-	-	EGP	ko:K18567	-	ko00000,ko02000	COG2814 Arabinose efflux permease
MKMBIGCO_00272	2.4e-170	ydhQ	-	-	K	ko:K03492	-	ko00000,ko03000	UTRA
MKMBIGCO_00273	1.09e-152	-	-	-	K	ko:K05799	-	ko00000,ko03000	FCD
MKMBIGCO_00274	2.04e-275	yycB1	-	-	P	ko:K03449	-	ko00000,ko02000	COG2807 Cyanate permease
MKMBIGCO_00275	1.48e-65	yvdR	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
MKMBIGCO_00276	4.48e-67	yvdS	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MKMBIGCO_00277	4.95e-134	yvdT_1	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00278	0.0	ybeC	-	-	E	-	-	-	amino acid
MKMBIGCO_00279	9.97e-211	ydhU	-	-	P	ko:K07217	-	ko00000	Catalase
MKMBIGCO_00280	2.7e-110	yndB	-	-	S	-	-	-	Activator of Hsp90 ATPase homolog 1-like protein
MKMBIGCO_00281	9.46e-236	yhfP	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Quinone oxidoreductase
MKMBIGCO_00282	0.0	iolT	-	-	U	ko:K02100,ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MKMBIGCO_00285	1.59e-212	ygxA	-	-	S	-	-	-	Nucleotidyltransferase-like
MKMBIGCO_00286	4.67e-75	ygzB	-	-	S	-	-	-	UPF0295 protein
MKMBIGCO_00287	2.37e-104	perR	-	-	P	ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
MKMBIGCO_00288	1.39e-111	bcp	1.11.1.15	-	O	ko:K03564	-	ko00000,ko01000	Peroxiredoxin
MKMBIGCO_00289	2.79e-313	gsaB	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MKMBIGCO_00290	5.27e-239	ygaE	-	-	S	-	-	-	Membrane
MKMBIGCO_00291	0.0	ygaD	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
MKMBIGCO_00292	2.32e-135	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
MKMBIGCO_00293	1.4e-49	ygaB	-	-	S	-	-	-	YgaB-like protein
MKMBIGCO_00294	4.77e-06	sspE	-	-	S	ko:K06422	-	ko00000	Small, acid-soluble spore protein, gamma-type
MKMBIGCO_00295	3.81e-173	fabL	1.3.1.104	-	IQ	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_00296	1.47e-49	yfhS	-	-	-	-	-	-	-
MKMBIGCO_00297	1.64e-261	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific
MKMBIGCO_00298	1.25e-235	yfhP	-	-	S	ko:K07038	-	ko00000	membrane-bound metal-dependent
MKMBIGCO_00299	0.0	yfhO	-	-	S	-	-	-	Bacterial membrane protein YfhO
MKMBIGCO_00300	1.35e-236	csbB	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MKMBIGCO_00301	2.28e-217	-	-	-	S	-	-	-	Alpha/beta hydrolase family
MKMBIGCO_00302	9.59e-54	yfhL	-	-	S	-	-	-	SdpI/YhfL protein family
MKMBIGCO_00303	4.68e-121	yfhK	-	-	T	-	-	-	Bacterial SH3 domain homologues
MKMBIGCO_00304	2.57e-59	yfhJ	-	-	S	-	-	-	WVELL protein
MKMBIGCO_00305	2.02e-215	mpr	-	-	M	-	-	-	Belongs to the peptidase S1B family
MKMBIGCO_00307	2.25e-265	yfhI	-	-	EGP	-	-	-	-transporter
MKMBIGCO_00308	3.1e-69	yfhH	-	-	S	-	-	-	Protein of unknown function (DUF1811)
MKMBIGCO_00309	5.21e-182	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Modulates RecA activity
MKMBIGCO_00310	2.01e-213	yfhF	-	-	S	ko:K07071	-	ko00000	nucleoside-diphosphate sugar epimerase
MKMBIGCO_00312	3.61e-34	yfhD	-	-	S	-	-	-	YfhD-like protein
MKMBIGCO_00313	4.76e-137	yfhC	-	-	C	-	-	-	nitroreductase
MKMBIGCO_00314	6.68e-205	yfhB	-	-	S	-	-	-	PhzF family
MKMBIGCO_00315	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MKMBIGCO_00316	2.29e-107	yfiV	-	-	K	-	-	-	transcriptional
MKMBIGCO_00317	0.0	yfiU	-	-	EGP	-	-	-	the major facilitator superfamily
MKMBIGCO_00318	1.82e-125	yfiT	-	-	S	-	-	-	Belongs to the metal hydrolase YfiT family
MKMBIGCO_00319	1.66e-60	yrdF	-	-	K	ko:K03623	-	ko00000	ribonuclease inhibitor
MKMBIGCO_00320	0.0	-	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
MKMBIGCO_00321	3.49e-232	yfiQ	-	-	G	ko:K21462	-	ko00000	COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MKMBIGCO_00322	3.47e-142	-	1.6.5.2	-	S	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
MKMBIGCO_00323	9.33e-125	padR	-	-	K	-	-	-	transcriptional
MKMBIGCO_00324	1.34e-210	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MKMBIGCO_00325	7.82e-204	yfiE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
MKMBIGCO_00326	7.86e-82	yfiD3	-	-	S	-	-	-	DoxX
MKMBIGCO_00327	0.0	yfiC3	-	-	V	ko:K06147	-	ko00000,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MKMBIGCO_00328	0.0	yfiB3	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MKMBIGCO_00329	0.0	glvC	2.7.1.208	-	G	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_00330	4.47e-178	glvR	-	-	F	ko:K03481	-	ko00000,ko03000	Helix-turn-helix domain, rpiR family
MKMBIGCO_00331	0.0	malH	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MKMBIGCO_00332	6.64e-22	sspH	-	-	S	ko:K06425	-	ko00000	Belongs to the SspH family
MKMBIGCO_00333	0.0	acoR	-	-	KQ	ko:K21405	-	ko00000,ko03000	COG3284 Transcriptional activator of acetoin glycerol metabolism
MKMBIGCO_00334	0.0	acoL	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MKMBIGCO_00335	3.79e-272	acoC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MKMBIGCO_00336	5.1e-240	acoB	-	-	C	ko:K21417	-	ko00000,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MKMBIGCO_00337	1.31e-242	acoA	-	-	C	ko:K21416	-	ko00000,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MKMBIGCO_00338	1.76e-112	yfjM	-	-	S	-	-	-	Psort location Cytoplasmic, score
MKMBIGCO_00339	4.22e-245	yfjN	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKMBIGCO_00340	2.4e-58	-	-	-	S	-	-	-	YfzA-like protein
MKMBIGCO_00341	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MKMBIGCO_00342	1.21e-208	yfjP	3.2.2.21	-	L	ko:K01247	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MKMBIGCO_00343	2.61e-235	corA	-	-	P	ko:K03284	-	ko00000,ko02000	Mediates influx of magnesium ions
MKMBIGCO_00345	2.98e-188	yfjR	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
MKMBIGCO_00346	4.36e-199	pdaA	-	-	G	ko:K01567	-	ko00000,ko01000	deacetylase
MKMBIGCO_00347	7.99e-37	yfjT	-	-	-	-	-	-	-
MKMBIGCO_00348	4.65e-279	yfkA	-	-	S	-	-	-	YfkB-like domain
MKMBIGCO_00349	6.79e-185	yfkC	-	-	M	-	-	-	Mechanosensitive ion channel
MKMBIGCO_00350	1.33e-184	yfkD	-	-	S	-	-	-	YfkD-like protein
MKMBIGCO_00351	1.7e-238	cax	-	-	P	ko:K07300	-	ko00000,ko02000	COG0387 Ca2 H antiporter
MKMBIGCO_00352	5.89e-278	yfkF	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_00353	6.71e-12	-	-	-	-	-	-	-	-
MKMBIGCO_00354	1.6e-184	yihY	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
MKMBIGCO_00355	2.14e-69	yfkI	-	-	S	-	-	-	gas vesicle protein
MKMBIGCO_00356	6.88e-112	yfkJ	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKMBIGCO_00357	1.47e-41	yfkK	-	-	S	-	-	-	Belongs to the UPF0435 family
MKMBIGCO_00358	3.85e-249	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_00359	2.04e-174	aroD	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
MKMBIGCO_00360	1.01e-208	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MKMBIGCO_00361	1.51e-237	-	-	-	K	ko:K02529	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MKMBIGCO_00362	7.82e-118	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
MKMBIGCO_00363	0.0	cpdB	3.1.3.5, 3.1.3.6, 3.1.4.16, 3.6.1.45	-	F	ko:K01081,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	COG0737 5'-nucleotidase 2',3'-cyclic phosphodiesterase and related esterases
MKMBIGCO_00364	1.22e-252	yibE	-	-	S	-	-	-	YibE/F-like protein
MKMBIGCO_00365	2.01e-165	yibF	-	-	S	-	-	-	YibE/F-like protein
MKMBIGCO_00366	1.19e-157	frp	-	-	C	-	-	-	nitroreductase
MKMBIGCO_00367	3.66e-165	treR	-	-	K	ko:K03486	-	ko00000,ko03000	transcriptional
MKMBIGCO_00368	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	COG0366 Glycosidases
MKMBIGCO_00369	1.57e-313	treP	2.7.1.201	-	G	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_00370	1.85e-53	ydgB	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
MKMBIGCO_00371	8.17e-52	ydgA	-	-	S	-	-	-	Spore germination protein gerPA/gerPF
MKMBIGCO_00372	8.64e-106	cotP	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MKMBIGCO_00373	4.9e-83	ydhN1	-	-	S	-	-	-	Domain of unknown function (DUF1992)
MKMBIGCO_00374	0.0	yflE	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Belongs to the LTA synthase family
MKMBIGCO_00375	1.17e-96	yfmQ	-	-	S	-	-	-	Uncharacterised protein from bacillus cereus group
MKMBIGCO_00376	0.0	nagE	2.7.1.193, 2.7.1.199	-	G	ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1263 Phosphotransferase system IIC components, glucose maltose N-acetylglucosamine-specific
MKMBIGCO_00377	1.9e-177	yflG	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine aminopeptidase
MKMBIGCO_00378	1.67e-66	yflH	-	-	S	-	-	-	Protein of unknown function (DUF3243)
MKMBIGCO_00379	1.98e-26	yflI	-	-	-	-	-	-	-
MKMBIGCO_00380	5.84e-21	yflJ	-	-	S	-	-	-	Protein of unknown function (DUF2639)
MKMBIGCO_00381	4.17e-157	yflK	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00382	3.93e-59	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
MKMBIGCO_00383	6.81e-276	nos	1.14.14.47	-	C	ko:K00491	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MKMBIGCO_00384	1.34e-189	yflN	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MKMBIGCO_00385	5.52e-285	citM	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
MKMBIGCO_00386	6.35e-226	yflP	-	-	S	-	-	-	Tripartite tricarboxylate transporter family receptor
MKMBIGCO_00387	9.33e-153	citT	-	-	T	ko:K11638	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
MKMBIGCO_00388	0.0	citS	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MKMBIGCO_00390	7.54e-07	-	-	-	S	-	-	-	domain, Protein
MKMBIGCO_00393	6.02e-57	-	-	-	Q	-	-	-	calcium- and calmodulin-responsive adenylate cyclase activity
MKMBIGCO_00394	4.61e-84	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MKMBIGCO_00395	1.54e-75	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MKMBIGCO_00396	2.45e-19	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
MKMBIGCO_00397	2.92e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MKMBIGCO_00398	7.99e-195	ypaH	-	-	EG	-	-	-	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
MKMBIGCO_00399	2.31e-195	-	-	-	S	-	-	-	Domain of unknown function (DUF5068)
MKMBIGCO_00401	2.95e-211	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
MKMBIGCO_00402	2.64e-86	yybR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00403	2.25e-109	cotF	-	-	M	ko:K06329	-	ko00000	Spore coat protein
MKMBIGCO_00405	2.48e-204	yybS	-	-	S	-	-	-	membrane
MKMBIGCO_00406	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
MKMBIGCO_00407	1.58e-95	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MKMBIGCO_00408	1.45e-158	-	-	-	KLT	-	-	-	COG0515 Serine threonine protein kinase
MKMBIGCO_00409	2.15e-157	-	-	-	S	-	-	-	GlcNAc-PI de-N-acetylase
MKMBIGCO_00410	1.18e-308	-	-	-	M	-	-	-	Glycosyltransferase Family 4
MKMBIGCO_00411	1.27e-294	-	-	-	S	-	-	-	Carbamoyl-phosphate synthase L chain, ATP binding domain
MKMBIGCO_00412	1.75e-256	-	-	-	S	-	-	-	Ecdysteroid kinase
MKMBIGCO_00413	3.18e-299	-	-	-	M	-	-	-	Glycosyltransferase Family 4
MKMBIGCO_00414	5.12e-25	yycC	-	-	K	-	-	-	YycC-like protein
MKMBIGCO_00416	6.11e-36	yycD	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2188)
MKMBIGCO_00417	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
MKMBIGCO_00418	1.29e-93	yycE	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MKMBIGCO_00419	1.55e-315	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKMBIGCO_00424	1.51e-172	yycF	-	-	T	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_00425	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_00426	0.0	yycH	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00427	1.98e-194	yycI	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00428	1.98e-191	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
MKMBIGCO_00429	1.1e-276	yyxA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKMBIGCO_00430	9.61e-14	phoP1	-	-	KT	ko:K02483	-	ko00000,ko02022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_00431	8.4e-314	-	2.7.13.3	-	T	ko:K02484	-	ko00000,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MKMBIGCO_00432	3.82e-240	thiF	2.7.7.73	-	H	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	ThiF family
MKMBIGCO_00433	0.0	-	-	-	-	-	-	-	-
MKMBIGCO_00434	1.85e-252	-	-	-	S	-	-	-	Major Facilitator Superfamily
MKMBIGCO_00435	0.0	-	-	-	S	-	-	-	ABC transporter
MKMBIGCO_00436	7.53e-188	-	1.14.11.27	-	P	ko:K10277	-	ko00000,ko01000,ko03036	peptidyl-arginine hydroxylation
MKMBIGCO_00437	0.0	rocR	-	-	KT	ko:K06714	-	ko00000,ko03000	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
MKMBIGCO_00438	2.69e-57	sdpR	-	-	K	-	-	-	transcriptional
MKMBIGCO_00439	2.07e-84	yvaZ	-	-	S	-	-	-	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane
MKMBIGCO_00440	6.81e-295	rocD	2.6.1.13	-	E	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Catalyzes the interconversion of ornithine to glutamate semialdehyde
MKMBIGCO_00441	0.0	rocE	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MKMBIGCO_00442	2.64e-212	rocF	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
MKMBIGCO_00443	3.7e-259	-	-	-	S	ko:K06361,ko:K06365,ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
MKMBIGCO_00445	8.36e-113	yycN	-	-	K	-	-	-	Acetyltransferase
MKMBIGCO_00446	1.24e-232	-	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
MKMBIGCO_00447	1.13e-169	yycO	-	-	S	-	-	-	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MKMBIGCO_00448	3.14e-275	yycP	-	-	-	-	-	-	-
MKMBIGCO_00451	4.11e-105	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MKMBIGCO_00452	2.12e-17	tnp	-	-	L	ko:K07493	-	ko00000	transposase activity
MKMBIGCO_00453	2.28e-242	-	-	-	KL	-	-	-	HELICc2
MKMBIGCO_00454	1.82e-41	csfB	-	-	S	-	-	-	Inhibitor of sigma-G Gin
MKMBIGCO_00455	1.19e-135	xpaC	-	-	S	-	-	-	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MKMBIGCO_00456	1.28e-239	yaaN	-	-	P	-	-	-	Belongs to the TelA family
MKMBIGCO_00457	0.0	yaaO	-	-	E	-	-	-	Orn Lys Arg decarboxylase
MKMBIGCO_00458	2.22e-144	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MKMBIGCO_00459	5.03e-73	yaaQ	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00460	2.98e-94	yaaR	-	-	S	ko:K09770	-	ko00000	protein conserved in bacteria
MKMBIGCO_00461	2.82e-235	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
MKMBIGCO_00462	9e-189	yaaT	-	-	S	-	-	-	stage 0 sporulation protein
MKMBIGCO_00463	3.08e-56	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
MKMBIGCO_00464	3.99e-178	yabB	2.1.1.223	-	S	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Conserved hypothetical protein 95
MKMBIGCO_00465	6.96e-64	yazA	-	-	L	ko:K07461	-	ko00000	endonuclease containing a URI domain
MKMBIGCO_00466	7.84e-208	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKMBIGCO_00467	6.14e-58	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	COG2002 Regulators of stationary sporulation gene expression
MKMBIGCO_00468	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKMBIGCO_00469	1.75e-183	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD
MKMBIGCO_00470	3.94e-307	yabE	-	-	T	-	-	-	protein conserved in bacteria
MKMBIGCO_00471	7.62e-126	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MKMBIGCO_00472	1.19e-202	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
MKMBIGCO_00473	5.75e-209	yabG	-	-	S	ko:K06436	-	ko00000	peptidase
MKMBIGCO_00474	5.32e-53	veg	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00475	7.31e-38	sspF	-	-	S	ko:K06423	-	ko00000	DNA topological change
MKMBIGCO_00476	7.83e-206	ispE	2.7.1.148	-	I	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MKMBIGCO_00477	5.67e-197	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
MKMBIGCO_00478	7.5e-83	yabJ	3.5.99.10	-	J	ko:K09022	-	ko00000,ko01000	translation initiation inhibitor, yjgF family
MKMBIGCO_00479	4.23e-64	spoVG	-	-	D	ko:K06412	-	ko00000	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation
MKMBIGCO_00480	0.0	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MKMBIGCO_00481	2.47e-223	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKMBIGCO_00482	7.21e-136	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MKMBIGCO_00483	1.74e-136	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
MKMBIGCO_00484	1.1e-54	yabK	-	-	S	-	-	-	Peptide ABC transporter permease
MKMBIGCO_00485	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKMBIGCO_00486	8.02e-119	spoVT	-	-	K	ko:K04769	-	ko00000,ko03000	stage V sporulation protein
MKMBIGCO_00487	0.0	yabM	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_00488	0.0	yabN	3.6.1.66	-	S	ko:K02428,ko:K02499	ko00230,map00230	ko00000,ko00001,ko01000,ko03036	COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like
MKMBIGCO_00489	1.42e-48	yabO	-	-	J	-	-	-	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
MKMBIGCO_00490	5.47e-66	yabP	-	-	S	-	-	-	Sporulation protein YabP
MKMBIGCO_00491	9.66e-134	yabQ	-	-	S	-	-	-	spore cortex biosynthesis protein
MKMBIGCO_00492	1.2e-74	divIC	-	-	D	ko:K13052	-	ko00000,ko03036	Septum formation initiator
MKMBIGCO_00493	3.54e-82	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
MKMBIGCO_00496	0.0	spoIIE	3.1.3.16	-	KT	ko:K06382	-	ko00000,ko01000	stage II sporulation protein E
MKMBIGCO_00497	3.79e-166	yabS	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MKMBIGCO_00498	1.34e-235	yabT	2.7.11.1	-	KLT	ko:K08884	-	ko00000,ko01000,ko01001	serine threonine protein kinase
MKMBIGCO_00499	0.0	tilS	2.4.2.8, 6.3.4.19	-	D	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
MKMBIGCO_00500	1.05e-119	hpt	2.4.2.8, 6.3.4.19	-	F	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Belongs to the purine pyrimidine phosphoribosyltransferase family
MKMBIGCO_00501	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKMBIGCO_00502	7.76e-186	coaX	2.7.1.33	-	F	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MKMBIGCO_00503	3.19e-206	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MKMBIGCO_00504	1.16e-193	yacD	5.2.1.8	-	O	ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl isomerase
MKMBIGCO_00505	7.3e-216	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
MKMBIGCO_00506	0.0	pabB	2.6.1.85	-	EH	ko:K01665	ko00790,map00790	ko00000,ko00001,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKMBIGCO_00507	1.79e-137	pabA	2.6.1.85	-	EH	ko:K01664	ko00790,map00790	ko00000,ko00001,ko01000	Anthranilate synthase
MKMBIGCO_00508	1.64e-205	pabC	4.1.3.38	-	EH	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	4-amino-4-deoxychorismate lyase
MKMBIGCO_00509	3.06e-201	folP	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MKMBIGCO_00510	1.13e-81	folB	1.13.11.81, 4.1.2.25, 5.1.99.8	-	H	ko:K01633	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MKMBIGCO_00511	7.88e-116	folK	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKMBIGCO_00512	6.1e-40	yazB	-	-	K	-	-	-	transcriptional
MKMBIGCO_00513	3.44e-238	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKMBIGCO_00514	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
MKMBIGCO_00515	0.0	sacC3	3.2.1.65	GH32	G	ko:K01212	ko00500,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 32 family
MKMBIGCO_00516	8.99e-148	-	-	-	K	-	-	-	FCD domain
MKMBIGCO_00517	2.74e-117	-	-	-	S	-	-	-	PFAM DinB family protein
MKMBIGCO_00518	1.97e-200	-	-	-	G	-	-	-	Major Facilitator Superfamily
MKMBIGCO_00519	1.12e-73	ypaA	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
MKMBIGCO_00520	1.7e-148	ydgI	-	-	C	-	-	-	nitroreductase
MKMBIGCO_00521	6.79e-90	-	-	-	K	-	-	-	Winged helix DNA-binding domain
MKMBIGCO_00522	5.16e-192	ydeO	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_00523	8.81e-98	yybA	-	-	K	-	-	-	transcriptional
MKMBIGCO_00524	1.38e-54	-	-	-	K	-	-	-	LysR substrate binding domain
MKMBIGCO_00525	9.36e-124	-	-	-	-	-	-	-	-
MKMBIGCO_00526	3.74e-208	-	-	-	M	-	-	-	Domain of Unknown Function (DUF1259)
MKMBIGCO_00527	5.27e-78	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Carboxymuconolactone decarboxylase family
MKMBIGCO_00528	6.64e-208	-	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00529	3.89e-175	bdh	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MKMBIGCO_00530	3.88e-315	ydfD	-	-	K	ko:K18907	-	ko00000,ko00002,ko01504,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MKMBIGCO_00531	1.73e-164	-	-	-	EG	-	-	-	EamA-like transporter family
MKMBIGCO_00532	3.81e-144	-	-	-	K	-	-	-	Bacterial transcription activator, effector binding domain
MKMBIGCO_00533	3.3e-127	-	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
MKMBIGCO_00534	3.45e-30	yyaL	-	-	O	ko:K06888	-	ko00000	Highly conserved protein containing a thioredoxin domain
MKMBIGCO_00535	0.0	yyaL	-	-	O	ko:K06888	-	ko00000	COG1331 Highly conserved protein containing a thioredoxin domain
MKMBIGCO_00536	5.73e-208	yyaK	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
MKMBIGCO_00537	7.51e-316	-	-	-	G	ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
MKMBIGCO_00538	3.43e-88	yyaH	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MKMBIGCO_00539	6.62e-230	ccpB	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00540	1.29e-181	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
MKMBIGCO_00541	1.32e-125	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKMBIGCO_00542	9.98e-134	adaA	-	-	K	ko:K13530	-	ko00000,ko01000,ko03000,ko03400	Transcriptional regulator
MKMBIGCO_00543	1.11e-49	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MKMBIGCO_00544	4.77e-99	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
MKMBIGCO_00545	2.9e-61	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
MKMBIGCO_00546	5.42e-254	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
MKMBIGCO_00547	0.0	yyaE	-	-	C	-	-	-	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MKMBIGCO_00548	1.82e-45	yyzM	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00549	9.63e-225	yyaD	-	-	S	-	-	-	Membrane
MKMBIGCO_00550	2.1e-60	yhhY	-	-	K	-	-	-	FR47-like protein
MKMBIGCO_00551	4.91e-144	yyaC	-	-	S	-	-	-	Sporulation protein YyaC
MKMBIGCO_00552	1.43e-189	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
MKMBIGCO_00553	9.68e-173	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	COG1192 ATPases involved in chromosome partitioning
MKMBIGCO_00554	6.61e-195	noc	-	-	D	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage
MKMBIGCO_00555	5.39e-163	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of guanine in position 535 of 16S rRNA
MKMBIGCO_00556	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
MKMBIGCO_00557	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MKMBIGCO_00558	4.45e-140	jag	-	-	S	ko:K06346	-	ko00000	single-stranded nucleic acid binding R3H
MKMBIGCO_00559	2.12e-179	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MKMBIGCO_00560	1.99e-71	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
MKMBIGCO_00561	5.59e-316	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MKMBIGCO_00562	8.12e-262	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
MKMBIGCO_00563	3.19e-45	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain
MKMBIGCO_00564	7.52e-263	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKMBIGCO_00565	6.18e-52	yaaB	-	-	S	-	-	-	Domain of unknown function (DUF370)
MKMBIGCO_00566	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKMBIGCO_00567	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKMBIGCO_00568	2.14e-100	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
MKMBIGCO_00569	1.89e-82	mcsA	-	-	S	ko:K19411	-	ko00000	protein with conserved CXXC pairs
MKMBIGCO_00570	1.63e-258	mcsB	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity
MKMBIGCO_00571	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Belongs to the ClpA ClpB family
MKMBIGCO_00572	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKMBIGCO_00573	8.93e-250	disA	2.7.7.85	-	L	ko:K07067	-	ko00000,ko01000	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MKMBIGCO_00574	8.6e-251	yacL	-	-	S	-	-	-	COG4956 Integral membrane protein (PIN domain superfamily)
MKMBIGCO_00575	1.01e-159	ispD	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
MKMBIGCO_00576	3.02e-111	ispF	2.7.7.60, 4.6.1.12	-	I	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
MKMBIGCO_00577	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKMBIGCO_00578	1.91e-152	cysE	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase
MKMBIGCO_00579	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
MKMBIGCO_00580	4.11e-95	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MKMBIGCO_00581	1.01e-172	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKMBIGCO_00582	4.71e-114	yacP	-	-	S	ko:K06962	-	ko00000	RNA-binding protein containing a PIN domain
MKMBIGCO_00583	1.39e-150	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	Belongs to the sigma-70 factor family
MKMBIGCO_00584	3.77e-32	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
MKMBIGCO_00585	1.28e-124	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
MKMBIGCO_00586	3.4e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MKMBIGCO_00587	8.66e-161	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
MKMBIGCO_00588	8.13e-104	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MKMBIGCO_00589	2.84e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
MKMBIGCO_00590	2.95e-139	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
MKMBIGCO_00591	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKMBIGCO_00592	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKMBIGCO_00593	5.94e-46	rplGB	-	-	J	ko:K07590	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the eukaryotic ribosomal protein eL8 family
MKMBIGCO_00594	9.47e-94	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MKMBIGCO_00595	4.85e-107	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
MKMBIGCO_00596	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKMBIGCO_00597	9.55e-286	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKMBIGCO_00598	5.06e-234	ybaC	-	-	S	-	-	-	Alpha/beta hydrolase family
MKMBIGCO_00599	2.58e-65	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
MKMBIGCO_00600	1.02e-143	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MKMBIGCO_00601	2.59e-136	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
MKMBIGCO_00602	3.27e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
MKMBIGCO_00603	9.5e-201	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MKMBIGCO_00604	2.83e-62	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MKMBIGCO_00605	9.23e-71	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MKMBIGCO_00606	1.69e-151	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MKMBIGCO_00607	1.38e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MKMBIGCO_00608	1.88e-35	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
MKMBIGCO_00609	1.64e-52	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MKMBIGCO_00610	1.04e-78	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MKMBIGCO_00611	1.43e-67	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MKMBIGCO_00612	5.43e-122	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MKMBIGCO_00613	1.43e-39	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MKMBIGCO_00614	1.08e-87	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MKMBIGCO_00615	3.14e-121	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MKMBIGCO_00616	8.29e-75	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MKMBIGCO_00617	4.54e-111	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MKMBIGCO_00618	1.59e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
MKMBIGCO_00619	2.1e-94	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	binds to the 23S rRNA
MKMBIGCO_00620	3.15e-295	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
MKMBIGCO_00621	4.34e-158	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
MKMBIGCO_00622	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00623	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00624	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00625	5.8e-234	yaaC	-	-	S	-	-	-	YaaC-like Protein
MKMBIGCO_00626	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
MKMBIGCO_00627	0.0	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MKMBIGCO_00628	1.29e-202	pdxS	4.3.3.6	-	H	ko:K06215	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MKMBIGCO_00629	1.17e-138	pdxT	4.3.3.6	-	H	ko:K08681	ko00750,map00750	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MKMBIGCO_00630	1.85e-284	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MKMBIGCO_00631	1.05e-254	glxK	2.7.1.165	-	G	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	ko00000,ko00001,ko01000	Belongs to the glycerate kinase type-1 family
MKMBIGCO_00633	2.94e-156	dck	2.7.1.74, 2.7.1.76	-	F	ko:K15519	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko01000	Deoxycytidine kinase
MKMBIGCO_00634	2.34e-148	dgk	2.7.1.113	-	F	ko:K15518	ko00230,map00230	ko00000,ko00001,ko01000	Deoxyguanosine kinase
MKMBIGCO_00635	2.9e-277	yaaH	-	-	M	ko:K06306	-	ko00000	Glycoside Hydrolase Family
MKMBIGCO_00636	1.18e-127	yaaI	-	-	Q	-	-	-	COG1335 Amidases related to nicotinamidase
MKMBIGCO_00637	1.18e-109	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
MKMBIGCO_00638	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKMBIGCO_00639	6.9e-52	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MKMBIGCO_00640	6e-142	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKMBIGCO_00641	5.4e-43	yaaL	-	-	S	-	-	-	Protein of unknown function (DUF2508)
MKMBIGCO_00642	6.44e-50	bofA	-	-	S	ko:K06317	-	ko00000	Sigma-K factor-processing regulatory protein BofA
MKMBIGCO_00643	0.0	-	-	-	Q	ko:K15665	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_00644	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_00645	1.63e-261	xkdO	-	-	L	-	-	-	Transglycosylase SLT domain
MKMBIGCO_00646	6.56e-145	xkdP	-	-	S	-	-	-	Lysin motif
MKMBIGCO_00647	2.66e-206	xkdQ	-	-	G	-	-	-	NLP P60 protein
MKMBIGCO_00648	2.51e-43	xkdR	-	-	S	-	-	-	Protein of unknown function (DUF2577)
MKMBIGCO_00649	9.98e-77	xkdS	-	-	S	-	-	-	Protein of unknown function (DUF2634)
MKMBIGCO_00650	1.08e-212	-	-	-	S	-	-	-	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology
MKMBIGCO_00651	2.03e-112	-	-	-	S	-	-	-	Uncharacterised protein conserved in bacteria (DUF2313)
MKMBIGCO_00652	3.63e-37	-	-	-	-	-	-	-	-
MKMBIGCO_00653	7.89e-111	-	-	-	-	-	-	-	-
MKMBIGCO_00655	1.55e-38	xkdX	-	-	-	-	-	-	-
MKMBIGCO_00656	6.09e-176	xepA	-	-	-	-	-	-	-
MKMBIGCO_00657	3.87e-51	xhlA	-	-	S	-	-	-	Haemolysin XhlA
MKMBIGCO_00658	4.7e-52	xhlB	-	-	S	-	-	-	SPP1 phage holin
MKMBIGCO_00659	6.03e-216	xlyA	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	n-acetylmuramoyl-L-alanine amidase
MKMBIGCO_00660	2.53e-31	spoIISB	-	-	S	ko:K06389	-	ko00000	Stage II sporulation protein SB
MKMBIGCO_00661	7.37e-170	spoIISA	-	-	S	ko:K06388	-	ko00000	Toxin SpoIISA, type II toxin-antitoxin system
MKMBIGCO_00662	7.07e-226	pit	-	-	P	ko:K03306	-	ko00000	phosphate transporter
MKMBIGCO_00663	1.85e-144	ykaA	-	-	P	ko:K07220	-	ko00000	COG1392 Phosphate transport regulator (distant homolog of PhoU)
MKMBIGCO_00664	9.38e-312	steT	-	-	E	ko:K03294	-	ko00000	amino acid
MKMBIGCO_00665	6.1e-228	ykcA	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MKMBIGCO_00666	0.0	ykcB	-	-	M	-	-	-	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MKMBIGCO_00667	5.21e-228	ykcC	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MKMBIGCO_00669	7.53e-276	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKMBIGCO_00670	0.0	yubD	-	-	P	-	-	-	Major Facilitator Superfamily
MKMBIGCO_00671	5.09e-199	dppA	-	-	E	ko:K16203	-	ko00000,ko01000,ko01002	D-aminopeptidase
MKMBIGCO_00672	2.3e-203	dppB	-	-	P	ko:K16200	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_00673	1.89e-226	dppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_00674	9.2e-243	dppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_00675	0.0	dppE	-	-	E	ko:K16199	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MKMBIGCO_00676	1.38e-226	ykfA	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	proteins, homologs of microcin C7 resistance protein MccF
MKMBIGCO_00677	3.53e-254	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
MKMBIGCO_00678	7.32e-216	ykfC	3.4.14.13	-	M	ko:K20742	-	ko00000,ko01000,ko01002	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MKMBIGCO_00679	6.62e-231	ykfD	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_00680	3.43e-262	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	6-phosphogluconolactonase
MKMBIGCO_00681	2.42e-203	ykgA	-	-	E	-	-	-	Amidinotransferase
MKMBIGCO_00682	2.16e-120	ykhA	-	-	I	-	-	-	Acyl-CoA hydrolase
MKMBIGCO_00683	2.59e-130	ykkB	-	-	J	-	-	-	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MKMBIGCO_00684	3.36e-68	ykkC	-	-	P	ko:K18924	-	ko00000,ko00002,ko02000	Multidrug resistance protein
MKMBIGCO_00685	1.17e-62	ykkD	-	-	P	ko:K18925	-	ko00000,ko00002,ko02000	Multidrug resistance protein
MKMBIGCO_00686	1.66e-217	purU	3.5.1.10	-	F	ko:K01433	ko00630,ko00670,map00630,map00670	ko00000,ko00001,ko01000	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
MKMBIGCO_00687	4.17e-260	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MKMBIGCO_00688	2.18e-287	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MKMBIGCO_00689	4.65e-91	ohrA	-	-	O	-	-	-	Organic hydroperoxide resistance protein
MKMBIGCO_00690	1.63e-99	ohrR	-	-	K	-	-	-	COG1846 Transcriptional regulators
MKMBIGCO_00691	1.92e-92	ohrB	-	-	O	-	-	-	Organic hydroperoxide resistance protein
MKMBIGCO_00692	4.03e-76	-	-	-	D	-	-	-	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKMBIGCO_00694	5.84e-274	-	-	-	M	-	-	-	Glycosyl transferase family 2
MKMBIGCO_00695	1.55e-170	-	-	-	M	-	-	-	PFAM Collagen triple helix repeat (20 copies)
MKMBIGCO_00696	4.45e-274	-	-	-	EGP	ko:K05820	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_00697	8.51e-157	nsr	-	-	T	-	-	-	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
MKMBIGCO_00698	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MKMBIGCO_00699	7.39e-226	isp	-	-	O	ko:K13275	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MKMBIGCO_00700	1.05e-188	yojH	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MKMBIGCO_00701	6.53e-171	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Cobalt transport protein
MKMBIGCO_00702	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_00703	2.31e-126	ykoE	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
MKMBIGCO_00704	1.04e-308	ydhD	-	-	M	-	-	-	Glycosyl hydrolase
MKMBIGCO_00706	2.89e-308	mgtE	-	-	P	ko:K06213	-	ko00000,ko02000	Acts as a magnesium transporter
MKMBIGCO_00707	1.23e-69	tnrA	-	-	K	-	-	-	transcriptional
MKMBIGCO_00708	1.11e-23	-	-	-	-	-	-	-	-
MKMBIGCO_00709	5.25e-37	ykoL	-	-	-	-	-	-	-
MKMBIGCO_00710	1.1e-104	ykoM	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
MKMBIGCO_00711	7.68e-129	ykoP	-	-	G	-	-	-	polysaccharide deacetylase
MKMBIGCO_00712	0.0	ligD	6.5.1.1	-	L	ko:K01971	ko03450,map03450	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA ligase
MKMBIGCO_00713	3.83e-199	ku	-	-	L	ko:K10979	ko03450,map03450	ko00000,ko00001,ko03400	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MKMBIGCO_00714	7.92e-129	ykoX	-	-	S	-	-	-	membrane-associated protein
MKMBIGCO_00715	1.38e-171	ykoY	-	-	P	-	-	-	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
MKMBIGCO_00716	6.02e-163	sigI	-	-	K	ko:K03093	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_00717	6.31e-231	ykrI	-	-	S	-	-	-	Anti-sigma factor N-terminus
MKMBIGCO_00718	5.7e-36	sspD	-	-	S	ko:K06421	-	ko00000	small acid-soluble spore protein
MKMBIGCO_00719	9.35e-161	ykrK	-	-	S	-	-	-	Domain of unknown function (DUF1836)
MKMBIGCO_00720	1.05e-198	htpX	-	-	O	ko:K03799	-	ko00000,ko00002,ko01000,ko01002	Belongs to the peptidase M48B family
MKMBIGCO_00721	3.8e-308	ktrD	-	-	P	-	-	-	COG0168 Trk-type K transport systems, membrane components
MKMBIGCO_00722	1.66e-145	-	-	-	S	-	-	-	Protein of unknown function (DUF421)
MKMBIGCO_00723	1.78e-31	ykzE	-	-	-	-	-	-	-
MKMBIGCO_00724	1.52e-240	ykrP	-	-	G	-	-	-	COG3594 Fucose 4-O-acetylase and related acetyltransferases
MKMBIGCO_00725	0.0	kinE	2.7.13.3	-	T	ko:K13533	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_00726	6.51e-114	ogt	2.1.1.63	-	L	ko:K00567,ko:K13531	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKMBIGCO_00728	1.09e-251	mtnA	5.3.1.23	-	E	ko:K08963	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MKMBIGCO_00729	2.34e-285	mtnK	2.7.1.100	-	F	ko:K00899	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MKMBIGCO_00730	1.64e-192	mtnU	3.5.1.3	-	S	ko:K13566	ko00250,map00250	ko00000,ko00001,ko01000	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MKMBIGCO_00731	6.03e-290	mtnE	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
MKMBIGCO_00732	4.53e-288	mtnW	5.3.2.5	-	G	ko:K08965	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the enolization of 2,3-diketo-5- methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5- methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)
MKMBIGCO_00733	4.33e-171	mtnX	3.1.3.87	-	E	ko:K08966	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MKMBIGCO_00734	1.51e-145	mtnB	4.2.1.109	-	E	ko:K08964	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)
MKMBIGCO_00735	6.12e-123	mtnD	1.13.11.53, 1.13.11.54	-	S	ko:K08967	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MKMBIGCO_00737	0.0	kinD	2.7.13.3	-	T	ko:K13532	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MKMBIGCO_00738	3.91e-100	ykvE	-	-	K	ko:K15973	-	ko00000,ko03000	transcriptional
MKMBIGCO_00739	4.04e-169	motB	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
MKMBIGCO_00740	4.74e-176	motA	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
MKMBIGCO_00741	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
MKMBIGCO_00742	4.26e-229	ykvI	-	-	S	-	-	-	membrane
MKMBIGCO_00743	1.36e-246	-	-	-	-	-	-	-	-
MKMBIGCO_00744	2.72e-162	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MKMBIGCO_00745	1.26e-102	queD	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	synthase
MKMBIGCO_00746	5.06e-179	queE	4.3.99.3	-	H	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
MKMBIGCO_00747	2.56e-124	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKMBIGCO_00748	2.54e-60	ykvR	-	-	S	-	-	-	Protein of unknown function (DUF3219)
MKMBIGCO_00749	5.43e-35	ykvS	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00750	2.92e-38	-	-	-	-	-	-	-	-
MKMBIGCO_00751	5.92e-142	ykvT	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell Wall Hydrolase
MKMBIGCO_00752	7.63e-306	ykvU	-	-	S	-	-	-	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_00753	1.22e-113	stoA	-	-	CO	-	-	-	thiol-disulfide
MKMBIGCO_00754	0.0	zosA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
MKMBIGCO_00755	5.5e-262	ykvY	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
MKMBIGCO_00757	3.93e-222	ykvZ	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00758	3.95e-199	glcT	-	-	K	ko:K03480,ko:K03488	-	ko00000,ko03000	antiterminator
MKMBIGCO_00759	0.0	ptsG	2.7.1.199	-	G	ko:K20116,ko:K20117,ko:K20118	ko00010,ko00520,ko02060,map00010,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_00760	1.51e-53	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPr
MKMBIGCO_00761	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKMBIGCO_00762	3.63e-50	splA	-	-	S	ko:K06315	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_00763	4.12e-255	splB	4.1.99.14	-	L	ko:K03716	-	ko00000,ko01000	Spore photoproduct lyase
MKMBIGCO_00764	0.0	mcpC	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MKMBIGCO_00765	8.11e-203	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
MKMBIGCO_00766	1.23e-147	ykwD	-	-	J	-	-	-	protein with SCP PR1 domains
MKMBIGCO_00767	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
MKMBIGCO_00768	0.0	kinA	2.7.13.3	-	T	ko:K02491	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_00769	1.62e-275	patA	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
MKMBIGCO_00770	6.38e-15	-	-	-	-	-	-	-	-
MKMBIGCO_00771	1.93e-213	cheV	-	-	T	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	Chemotaxis protein CheV
MKMBIGCO_00772	5.07e-108	ykyB	-	-	S	-	-	-	YkyB-like protein
MKMBIGCO_00773	4.41e-306	ykuC	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_00774	8.88e-117	ykuD	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00775	8.63e-196	ykuE	-	-	S	ko:K07098	-	ko00000	Metallophosphoesterase
MKMBIGCO_00776	1.06e-181	fadH	1.3.1.34	-	IQ	ko:K00219	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_00778	3.67e-295	ykuI	-	-	T	-	-	-	Diguanylate phosphodiesterase
MKMBIGCO_00779	3.63e-50	ykuJ	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00780	2.52e-119	ykuK	-	-	S	ko:K09776	-	ko00000	Ribonuclease H-like
MKMBIGCO_00781	3.09e-35	ykzF	-	-	S	-	-	-	Antirepressor AbbA
MKMBIGCO_00782	8.55e-99	ykuL	-	-	S	-	-	-	CBS domain
MKMBIGCO_00783	5.36e-215	ccpC	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_00784	1.83e-116	ykuN	-	-	C	ko:K03839	-	ko00000	Flavodoxin
MKMBIGCO_00785	2.35e-211	ykuO	-	-	-	-	-	-	-
MKMBIGCO_00786	5.1e-102	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
MKMBIGCO_00787	2.89e-129	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
MKMBIGCO_00788	3.25e-275	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
MKMBIGCO_00789	2.15e-52	ykuS	-	-	S	-	-	-	Belongs to the UPF0180 family
MKMBIGCO_00790	1.48e-179	ykuT	-	-	M	ko:K22044	-	ko00000,ko02000	Mechanosensitive ion channel
MKMBIGCO_00791	2.51e-98	ykuV	-	-	CO	-	-	-	thiol-disulfide
MKMBIGCO_00792	3.04e-126	rok	-	-	K	-	-	-	Repressor of ComK
MKMBIGCO_00793	1.98e-215	yknT	-	-	-	ko:K06437	-	ko00000	-
MKMBIGCO_00794	6.72e-140	mobA	2.7.7.77	-	H	ko:K03752	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
MKMBIGCO_00795	9.91e-241	moeB	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MKMBIGCO_00796	3.24e-308	moeA	2.10.1.1	-	H	ko:K03750	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	molybdopterin
MKMBIGCO_00797	3.6e-119	mobB	-	-	H	ko:K03753	-	ko00000	molybdopterin-guanine dinucleotide biosynthesis protein
MKMBIGCO_00798	8.37e-108	moaE	2.8.1.12	-	H	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	COG0314 Molybdopterin converting factor, large subunit
MKMBIGCO_00799	3.43e-45	moaD	-	-	H	ko:K03636	ko04122,map04122	ko00000,ko00001	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MKMBIGCO_00800	2.24e-131	yknW	-	-	S	-	-	-	Yip1 domain
MKMBIGCO_00801	2.27e-236	yknX	-	-	M	ko:K02005,ko:K13888	-	ko00000,ko00002,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKMBIGCO_00802	1.96e-156	yknY	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_00803	3.47e-268	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
MKMBIGCO_00804	1.32e-169	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_00805	4.75e-214	pfkB	2.7.1.56	-	G	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family
MKMBIGCO_00806	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
MKMBIGCO_00807	3.77e-138	sipT	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MKMBIGCO_00808	4.3e-49	ykoA	-	-	-	-	-	-	-
MKMBIGCO_00809	0.0	ykpA	-	-	S	-	-	-	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
MKMBIGCO_00810	4.91e-211	panE1	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKMBIGCO_00811	1.34e-299	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	COG2309 Leucyl aminopeptidase (aminopeptidase T)
MKMBIGCO_00812	4.47e-18	-	-	-	S	-	-	-	Uncharacterized protein YkpC
MKMBIGCO_00813	3.72e-235	mreBH	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod-share determining protein MreBH
MKMBIGCO_00814	7.46e-59	abrB	-	-	K	ko:K06284	-	ko00000,ko03000	of stationary sporulation gene expression
MKMBIGCO_00815	1.61e-310	kinC	2.7.13.3	-	T	ko:K07698	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	COG0642 Signal transduction histidine kinase
MKMBIGCO_00816	4.85e-193	ykqA	-	-	P	-	-	-	Gamma-glutamyl cyclotransferase, AIG2-like
MKMBIGCO_00817	9.71e-148	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
MKMBIGCO_00818	0.0	ade	3.5.4.2	-	F	ko:K01486	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MKMBIGCO_00819	0.0	rnjA	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MKMBIGCO_00820	4.45e-42	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
MKMBIGCO_00821	2.5e-186	ykrA	-	-	S	-	-	-	hydrolases of the HAD superfamily
MKMBIGCO_00822	1.14e-130	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MKMBIGCO_00823	1.21e-06	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
MKMBIGCO_00824	5.36e-132	ykyA	-	-	L	-	-	-	Putative cell-wall binding lipoprotein
MKMBIGCO_00825	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_00826	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00827	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	polyketide synthase
MKMBIGCO_00828	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00829	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00830	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00831	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_00832	0.0	-	-	-	IQ	-	-	-	Phosphopantetheine attachment site
MKMBIGCO_00833	4.54e-265	-	-	-	V	-	-	-	Beta-lactamase
MKMBIGCO_00834	7.79e-261	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MKMBIGCO_00835	1.01e-226	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MKMBIGCO_00836	1.4e-299	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MKMBIGCO_00837	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MKMBIGCO_00838	3.24e-58	slp	-	-	CO	-	-	-	COG0526, thiol-disulfide isomerase and thioredoxins
MKMBIGCO_00839	6.32e-186	pdaA_2	3.5.1.104	-	G	ko:K01567,ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
MKMBIGCO_00840	0.0	speA	4.1.1.17, 4.1.1.19	-	E	ko:K01581,ko:K01585	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Arginine
MKMBIGCO_00841	1.9e-56	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
MKMBIGCO_00842	3.32e-154	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
MKMBIGCO_00843	7.89e-32	ykzI	-	-	-	-	-	-	-
MKMBIGCO_00844	3.31e-195	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase
MKMBIGCO_00845	1.86e-49	ykzC	-	-	S	-	-	-	Acetyltransferase (GNAT) family
MKMBIGCO_00846	0.0	mpl	3.4.24.28, 3.4.24.29	-	E	ko:K01400,ko:K01401,ko:K19351	ko01503,ko05150,map01503,map05150	ko00000,ko00001,ko01000,ko01002	Peptidase M4
MKMBIGCO_00848	6.1e-59	ylaE	-	-	-	-	-	-	-
MKMBIGCO_00849	3.26e-32	-	-	-	S	-	-	-	Family of unknown function (DUF5325)
MKMBIGCO_00850	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
MKMBIGCO_00851	4.05e-64	-	-	-	S	-	-	-	YlaH-like protein
MKMBIGCO_00852	1.37e-45	ylaI	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00853	1.83e-136	ylaJ	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MKMBIGCO_00854	1.01e-308	ylaK	-	-	T	ko:K07175	-	ko00000	ATPase related to phosphate starvation-inducible protein PhoH
MKMBIGCO_00855	1.18e-108	ylaL	-	-	S	-	-	-	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKMBIGCO_00856	1.81e-221	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
MKMBIGCO_00857	1.99e-58	ylaN	-	-	S	-	-	-	Belongs to the UPF0358 family
MKMBIGCO_00858	2.02e-270	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MKMBIGCO_00859	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MKMBIGCO_00860	3.47e-214	ctaA	-	-	O	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	ko00000,ko00001,ko00002,ko03029	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group
MKMBIGCO_00861	2.07e-209	ctaB	2.5.1.141	-	O	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
MKMBIGCO_00862	3.95e-251	ctaC	1.9.3.1	-	C	ko:K02275	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
MKMBIGCO_00863	0.0	ctaD	1.9.3.1	-	C	ko:K02274	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKMBIGCO_00864	2.41e-141	ctaE	1.9.3.1	-	C	ko:K02276	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3
MKMBIGCO_00865	3.97e-66	ctaF	1.9.3.1	-	C	ko:K02277	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	COG3125 Heme copper-type cytochrome quinol oxidase, subunit 4
MKMBIGCO_00866	3.45e-210	ctaG	-	-	S	ko:K02862	-	ko00000	cytochrome c oxidase
MKMBIGCO_00867	1.68e-78	ylbA	-	-	S	-	-	-	YugN-like family
MKMBIGCO_00868	3.35e-96	ylbB	-	-	T	-	-	-	COG0517 FOG CBS domain
MKMBIGCO_00869	3.26e-254	ylbC	-	-	S	-	-	-	protein with SCP PR1 domains
MKMBIGCO_00870	6.69e-84	ylbD	-	-	S	-	-	-	Putative coat protein
MKMBIGCO_00871	1.73e-48	ylbE	-	-	S	-	-	-	YlbE-like protein
MKMBIGCO_00872	3.33e-97	ylbF	-	-	S	-	-	-	Belongs to the UPF0342 family
MKMBIGCO_00873	5.61e-57	ylbG	-	-	S	-	-	-	UPF0298 protein
MKMBIGCO_00875	1.01e-124	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	Methyltransferase
MKMBIGCO_00876	6.83e-109	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MKMBIGCO_00877	4.16e-275	ylbJ	-	-	S	-	-	-	Sporulation integral membrane protein YlbJ
MKMBIGCO_00878	2.48e-178	ylbK	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
MKMBIGCO_00879	6.2e-240	ylbL	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
MKMBIGCO_00880	8.29e-292	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
MKMBIGCO_00881	4.69e-115	ylbN	-	-	S	ko:K07040	-	ko00000	metal-binding, possibly nucleic acid-binding protein
MKMBIGCO_00882	1.71e-37	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
MKMBIGCO_00883	3.13e-111	ylbO	-	-	S	ko:K06314	-	ko00000,ko03000	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
MKMBIGCO_00884	1.89e-115	ylbP	-	-	K	-	-	-	n-acetyltransferase
MKMBIGCO_00885	1.68e-210	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKMBIGCO_00886	0.0	bshC	-	-	S	ko:K22136	-	ko00000	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MKMBIGCO_00887	9.07e-102	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
MKMBIGCO_00888	1.66e-218	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
MKMBIGCO_00889	2.4e-68	ftsL	-	-	D	-	-	-	Essential cell division protein
MKMBIGCO_00890	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
MKMBIGCO_00891	0.0	spoVD	-	-	M	ko:K08384	ko00550,map00550	ko00000,ko00001,ko01011	stage V sporulation protein D
MKMBIGCO_00892	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MKMBIGCO_00893	7.04e-222	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKMBIGCO_00894	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MKMBIGCO_00895	2.7e-236	spoVE	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MKMBIGCO_00896	5.69e-259	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MKMBIGCO_00897	7.87e-213	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	cell wall formation
MKMBIGCO_00898	1.04e-176	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
MKMBIGCO_00899	1.57e-298	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
MKMBIGCO_00900	2.61e-260	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKMBIGCO_00901	0.0	bpr	-	-	O	ko:K13276	-	ko00000,ko01000,ko01002,ko03110	COG1404 Subtilisin-like serine proteases
MKMBIGCO_00902	4.56e-215	spoIIGA	-	-	M	ko:K06383	-	ko00000,ko01000,ko01002	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR
MKMBIGCO_00903	7.35e-161	sigE	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_00904	9.33e-179	sigG	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_00905	2.21e-184	ylmA	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1119 ABC-type molybdenum transport system, ATPase component photorepair protein PhrA
MKMBIGCO_00906	0.0	argE	-	-	E	ko:K20895	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Acetylornithine deacetylase
MKMBIGCO_00907	7.13e-52	ylmC	-	-	S	-	-	-	sporulation protein
MKMBIGCO_00908	9.55e-206	ylmD	-	-	S	ko:K05810	-	ko00000,ko01000	Belongs to the multicopper oxidase YfiH RL5 family
MKMBIGCO_00909	1.05e-160	ylmE	-	-	S	ko:K06997	-	ko00000	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MKMBIGCO_00910	4.61e-85	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
MKMBIGCO_00911	5.12e-56	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	membrane
MKMBIGCO_00912	5.03e-181	ylmH	-	-	S	-	-	-	conserved protein, contains S4-like domain
MKMBIGCO_00913	1.85e-99	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	Cell division initiation protein
MKMBIGCO_00914	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MKMBIGCO_00915	4.75e-80	ylyA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
MKMBIGCO_00916	1.24e-103	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MKMBIGCO_00917	6.24e-215	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
MKMBIGCO_00918	2.21e-122	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MKMBIGCO_00919	3.28e-295	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Xanthine uracil
MKMBIGCO_00920	2.44e-212	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
MKMBIGCO_00921	7.41e-313	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
MKMBIGCO_00922	3.09e-268	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
MKMBIGCO_00923	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the CarB family
MKMBIGCO_00924	7.44e-183	pyrK	-	-	C	ko:K02823	ko00240,ko01100,map00240,map01100	ko00000,ko00001	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
MKMBIGCO_00925	1.22e-220	pyrD	1.3.1.14	-	F	ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
MKMBIGCO_00926	1.74e-161	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
MKMBIGCO_00927	1.49e-147	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MKMBIGCO_00928	4.03e-180	cysH	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the PAPS reductase family. CysH subfamily
MKMBIGCO_00929	3.87e-225	cysP	-	-	P	ko:K16331	-	ko00000,ko02000	phosphate transporter
MKMBIGCO_00930	1.77e-283	sat	2.7.7.4	-	P	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the sulfate adenylyltransferase family
MKMBIGCO_00931	9.22e-141	cysC	2.7.1.25	-	P	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of activated sulfate
MKMBIGCO_00932	2.81e-183	cobA	2.1.1.107	-	H	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
MKMBIGCO_00933	1.14e-184	sirB	4.99.1.4	-	S	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sirohydrochlorin ferrochelatase
MKMBIGCO_00934	2.01e-102	sirC	1.3.1.76, 4.99.1.4	-	H	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Siroheme synthase
MKMBIGCO_00935	0.0	FbpA	-	-	K	-	-	-	RNA-binding protein homologous to eukaryotic snRNP
MKMBIGCO_00936	0.0	yloB	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	COG0474 Cation transport ATPase
MKMBIGCO_00937	2.5e-197	yloC	-	-	S	-	-	-	stress-induced protein
MKMBIGCO_00938	3.97e-54	ylzA	-	-	S	ko:K09777	-	ko00000	Belongs to the UPF0296 family
MKMBIGCO_00939	4.91e-144	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
MKMBIGCO_00940	2.53e-38	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
MKMBIGCO_00941	1.08e-287	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKMBIGCO_00942	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKMBIGCO_00943	1.18e-109	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
MKMBIGCO_00944	6.21e-220	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MKMBIGCO_00945	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKMBIGCO_00946	1.52e-263	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MKMBIGCO_00947	1.17e-176	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
MKMBIGCO_00948	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
MKMBIGCO_00949	2.53e-210	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
MKMBIGCO_00950	1.4e-150	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
MKMBIGCO_00951	1.3e-153	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
MKMBIGCO_00952	3.49e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
MKMBIGCO_00953	3.65e-78	yloU	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_00954	0.0	yloV	-	-	S	ko:K07030	-	ko00000	kinase related to dihydroxyacetone kinase
MKMBIGCO_00955	4.15e-153	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
MKMBIGCO_00956	2.4e-201	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase
MKMBIGCO_00957	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKMBIGCO_00958	4.38e-121	fapR	-	-	K	-	-	-	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism
MKMBIGCO_00959	3.14e-229	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
MKMBIGCO_00960	3.76e-218	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_00961	8.61e-168	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
MKMBIGCO_00962	1.15e-43	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKMBIGCO_00963	1.43e-172	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
MKMBIGCO_00964	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
MKMBIGCO_00965	1.87e-224	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MKMBIGCO_00966	5.87e-180	-	-	-	S	-	-	-	Phosphotransferase enzyme family
MKMBIGCO_00967	1.97e-66	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MKMBIGCO_00968	9.92e-302	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKMBIGCO_00969	1.13e-58	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
MKMBIGCO_00970	4.9e-49	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
MKMBIGCO_00971	3.41e-80	ylqD	-	-	S	-	-	-	YlqD protein
MKMBIGCO_00972	1.51e-121	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MKMBIGCO_00973	5.67e-176	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
MKMBIGCO_00974	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
MKMBIGCO_00975	4.19e-202	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKMBIGCO_00976	6.81e-174	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKMBIGCO_00977	0.0	ylqG	-	-	-	-	-	-	-
MKMBIGCO_00978	6.94e-59	ylqH	-	-	S	ko:K04061	-	ko00000,ko02044	homolog of the cytoplasmic domain of flagellar protein FhlB
MKMBIGCO_00979	2.02e-270	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
MKMBIGCO_00980	7.59e-214	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MKMBIGCO_00981	2.1e-215	dprA	-	-	LU	ko:K04096	-	ko00000	Rossmann fold nucleotide-binding protein involved in DNA uptake
MKMBIGCO_00982	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKMBIGCO_00983	1.1e-313	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MKMBIGCO_00984	6.29e-220	xerC	-	-	L	ko:K03733,ko:K04763	-	ko00000,ko03036	tyrosine recombinase XerC
MKMBIGCO_00985	7.38e-121	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MKMBIGCO_00986	0.0	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MKMBIGCO_00987	2.77e-175	codY	-	-	K	ko:K03706	-	ko00000,ko03000	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MKMBIGCO_00988	2.8e-84	flgB	-	-	N	ko:K02387	ko02040,map02040	ko00000,ko00001,ko02035	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
MKMBIGCO_00989	2.63e-99	flgC	-	-	N	ko:K02388	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the flagella basal body rod proteins family
MKMBIGCO_00990	1.51e-50	fliE	-	-	N	ko:K02408	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-basal body
MKMBIGCO_00991	0.0	fliF	-	-	N	ko:K02409	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	The M ring may be actively involved in energy transduction
MKMBIGCO_00992	2.48e-229	fliG	-	-	N	ko:K02410	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MKMBIGCO_00993	3.1e-119	fliH	-	-	NU	ko:K02411	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	COG1317 Flagellar biosynthesis type III secretory pathway protein
MKMBIGCO_00994	3e-308	fliI	3.6.3.14	-	NU	ko:K02412	ko02040,map02040	ko00000,ko00001,ko01000,ko02035,ko02044	COG1157 Flagellar biosynthesis type III secretory pathway ATPase
MKMBIGCO_00995	2.17e-92	fliJ	-	-	N	ko:K02413	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar biosynthesis chaperone
MKMBIGCO_00996	1.98e-88	ylxF	-	-	S	-	-	-	MgtE intracellular N domain
MKMBIGCO_00997	4.96e-259	fliK	-	-	N	ko:K02414	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar hook-length control protein
MKMBIGCO_00998	1.8e-95	flgD	-	-	N	ko:K02389	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod modification protein
MKMBIGCO_00999	4.62e-178	flgG	-	-	N	ko:K02390	ko02040,map02040	ko00000,ko00001,ko02035	Flagellar basal body rod
MKMBIGCO_01000	6.59e-81	fliL	-	-	N	ko:K02415	-	ko00000,ko02035	Controls the rotational direction of flagella during chemotaxis
MKMBIGCO_01001	5.43e-230	fliM	-	-	N	ko:K02416	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation
MKMBIGCO_01002	6.97e-247	fliY	-	-	N	ko:K02417	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02035,ko02044	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MKMBIGCO_01003	2.12e-77	cheY	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	response regulator
MKMBIGCO_01004	9.34e-144	fliZ	-	-	N	ko:K02418	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthesis protein, FliO
MKMBIGCO_01005	8.55e-142	fliP	-	-	N	ko:K02419	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Plays a role in the flagellum-specific transport system
MKMBIGCO_01006	3.15e-51	fliQ	-	-	N	ko:K02420	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Role in flagellar biosynthesis
MKMBIGCO_01007	5.74e-168	fliR	-	-	N	ko:K02421	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Flagellar biosynthetic protein FliR
MKMBIGCO_01008	1.03e-241	flhB	-	-	N	ko:K02401	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MKMBIGCO_01009	0.0	flhA	-	-	N	ko:K02400	ko02040,map02040	ko00000,ko00001,ko02035,ko02044	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MKMBIGCO_01010	1.79e-246	flhF	-	-	N	ko:K02404	-	ko00000,ko02035	Flagellar biosynthesis regulator FlhF
MKMBIGCO_01011	7.73e-201	ylxH	-	-	D	ko:K04562	-	ko00000,ko02035	Belongs to the ParA family
MKMBIGCO_01012	3.35e-247	cheB	3.1.1.61, 3.5.1.44	-	NT	ko:K03412	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
MKMBIGCO_01013	0.0	cheA	2.7.13.3	-	NT	ko:K03407	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	COG0643 Chemotaxis protein histidine kinase and related kinases
MKMBIGCO_01014	2.49e-105	cheW	-	-	NT	ko:K03408	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	COG0835 Chemotaxis signal transduction protein
MKMBIGCO_01015	3.42e-142	cheC	-	-	NT	ko:K03410	ko02030,map02030	ko00000,ko00001,ko02035	COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
MKMBIGCO_01016	2.86e-113	cheD	3.5.1.44	-	NT	ko:K03411	ko02030,map02030	ko00000,ko00001,ko01000,ko02035	Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase
MKMBIGCO_01017	3.96e-177	sigD	-	-	K	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	ko00000,ko00001,ko02035,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_01018	1.01e-90	ylxL	-	-	-	-	-	-	-
MKMBIGCO_01019	1.74e-167	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
MKMBIGCO_01020	9.41e-200	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MKMBIGCO_01021	7.09e-164	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
MKMBIGCO_01022	1.94e-118	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
MKMBIGCO_01023	2.22e-186	uppS	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKMBIGCO_01024	3.8e-179	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
MKMBIGCO_01025	2.2e-273	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
MKMBIGCO_01026	1.15e-296	rasP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
MKMBIGCO_01027	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
MKMBIGCO_01028	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKMBIGCO_01029	9.4e-105	rimP	-	-	S	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
MKMBIGCO_01030	4.04e-264	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
MKMBIGCO_01031	6.76e-56	ylxR	-	-	K	ko:K07742	-	ko00000	nucleic-acid-binding protein implicated in transcription termination
MKMBIGCO_01032	6.16e-63	ylxQ	-	-	J	-	-	-	ribosomal protein
MKMBIGCO_01033	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MKMBIGCO_01034	3.88e-60	ylxP	-	-	S	ko:K09764	-	ko00000	protein conserved in bacteria
MKMBIGCO_01035	1.03e-73	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MKMBIGCO_01036	3.49e-219	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MKMBIGCO_01037	5.25e-232	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
MKMBIGCO_01038	4.12e-56	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MKMBIGCO_01039	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
MKMBIGCO_01040	1.19e-231	ylxY	-	-	G	-	-	-	Sporulation protein, polysaccharide deacetylase
MKMBIGCO_01041	2.41e-298	mlpA	-	-	S	-	-	-	Belongs to the peptidase M16 family
MKMBIGCO_01042	2.17e-56	ymxH	-	-	S	-	-	-	YlmC YmxH family
MKMBIGCO_01043	1.91e-205	dpaA	-	-	CH	ko:K06410	-	ko00000	Dipicolinate synthase subunit A
MKMBIGCO_01044	4.75e-138	spoVFB	-	-	H	ko:K06411	-	ko00000	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)
MKMBIGCO_01045	3.92e-246	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKMBIGCO_01046	2.83e-282	dapG	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MKMBIGCO_01047	7.2e-202	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKMBIGCO_01048	0.0	rnjB	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MKMBIGCO_01049	1.86e-165	tepA	-	-	OU	-	-	-	COG0740 Protease subunit of ATP-dependent Clp proteases
MKMBIGCO_01050	6.32e-42	-	-	-	S	-	-	-	YlzJ-like protein
MKMBIGCO_01051	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
MKMBIGCO_01052	2.59e-171	ymfC	-	-	K	ko:K03710	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_01053	7.1e-293	ymfD	-	-	EGP	ko:K08221	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_01054	9.88e-100	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_01055	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	drug exporters of the RND superfamily
MKMBIGCO_01056	5.12e-303	albE	-	-	S	-	-	-	Peptidase M16
MKMBIGCO_01057	3.77e-306	ymfH	-	-	S	-	-	-	zinc protease
MKMBIGCO_01058	4.1e-164	ymfI	1.1.1.100	-	S	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
MKMBIGCO_01059	6.23e-56	ymfJ	-	-	S	-	-	-	Protein of unknown function (DUF3243)
MKMBIGCO_01060	3.14e-183	ymfK	-	-	S	-	-	-	Protein of unknown function (DUF3388)
MKMBIGCO_01061	4.2e-176	ymfM	-	-	S	ko:K15539	-	ko00000	protein conserved in bacteria
MKMBIGCO_01062	1.36e-131	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKMBIGCO_01063	1.89e-293	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
MKMBIGCO_01064	3.06e-239	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKMBIGCO_01065	2.22e-278	pbpX	-	-	V	-	-	-	Beta-lactamase
MKMBIGCO_01066	2.91e-308	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
MKMBIGCO_01067	3.72e-196	ymdB	-	-	S	ko:K02029,ko:K02030,ko:K09769	-	ko00000,ko00002,ko02000	protein conserved in bacteria
MKMBIGCO_01068	2.44e-49	spoVS	-	-	S	ko:K06416	-	ko00000	Stage V sporulation protein S
MKMBIGCO_01069	3.94e-249	tdh	1.1.1.103	-	C	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
MKMBIGCO_01070	1.43e-273	kbl	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MKMBIGCO_01071	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKMBIGCO_01072	2.11e-88	ymcA	3.6.3.21	-	S	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	Belongs to the UPF0342 family
MKMBIGCO_01073	7.09e-119	cotE	-	-	S	ko:K06328	-	ko00000	Spore coat protein
MKMBIGCO_01074	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKMBIGCO_01075	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKMBIGCO_01077	4.05e-166	pksB	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	Polyketide biosynthesis
MKMBIGCO_01078	2.25e-205	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_01079	2.6e-233	pksD	-	-	Q	ko:K15328	-	ko00000,ko01008	Acyl transferase domain
MKMBIGCO_01080	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_01081	1.46e-46	acpK	-	-	IQ	ko:K15337	-	ko00000,ko01008	Phosphopantetheine attachment site
MKMBIGCO_01082	4.95e-307	pksG	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
MKMBIGCO_01083	1.76e-186	-	-	-	I	ko:K15312	-	ko00000,ko01008	enoyl-CoA hydratase
MKMBIGCO_01084	3.42e-180	pksI	-	-	I	ko:K15313	-	ko00000,ko01008	Belongs to the enoyl-CoA hydratase isomerase family
MKMBIGCO_01085	0.0	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MKMBIGCO_01086	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_01087	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_01088	0.0	-	-	-	IQ	ko:K13611,ko:K13614	-	ko00000,ko01004,ko01008	polyketide synthase
MKMBIGCO_01089	0.0	-	-	-	HQ	ko:K13615	-	ko00000,ko01004,ko01008	Beta-ketoacyl synthase
MKMBIGCO_01090	1.54e-290	cypA	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MKMBIGCO_01091	1.74e-101	nucB	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
MKMBIGCO_01092	1.23e-151	yoaK	-	-	S	-	-	-	Membrane
MKMBIGCO_01093	3.25e-81	ymzB	-	-	-	-	-	-	-
MKMBIGCO_01094	0.0	aprX	-	-	O	ko:K17734	-	ko00000,ko01000,ko01002	Belongs to the peptidase S8 family
MKMBIGCO_01095	2.68e-161	ymaC	-	-	S	-	-	-	Replication protein
MKMBIGCO_01096	3.46e-104	ymaD	-	-	O	-	-	-	redox protein, regulator of disulfide bond formation
MKMBIGCO_01097	3.04e-71	ebrB	-	-	P	ko:K03297,ko:K11814,ko:K11815	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MKMBIGCO_01098	1.5e-62	ebrA	-	-	P	ko:K11814	-	ko00000,ko00002,ko02000	Small Multidrug Resistance protein
MKMBIGCO_01100	8.12e-75	ymaF	-	-	S	-	-	-	YmaF family
MKMBIGCO_01101	8.91e-220	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MKMBIGCO_01102	9e-46	hfq	-	-	J	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	ko00000,ko00001,ko03019,ko03036	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
MKMBIGCO_01103	1.94e-55	-	-	-	-	-	-	-	-
MKMBIGCO_01104	9.42e-29	ymzA	-	-	-	-	-	-	-
MKMBIGCO_01105	9.34e-88	nrdI	-	-	F	ko:K03647	-	ko00000	Probably involved in ribonucleotide reductase function
MKMBIGCO_01106	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKMBIGCO_01107	6.19e-239	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKMBIGCO_01108	7.48e-140	ymaB	-	-	S	-	-	-	MutT family
MKMBIGCO_01109	6.99e-149	cwlC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MKMBIGCO_01110	1.55e-226	spoVK	-	-	O	ko:K06413	-	ko00000	stage V sporulation protein K
MKMBIGCO_01111	2.7e-295	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKMBIGCO_01112	4.1e-311	ynbB	-	-	P	-	-	-	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
MKMBIGCO_01113	5.34e-89	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	transcriptional
MKMBIGCO_01114	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
MKMBIGCO_01115	2.3e-32	-	-	-	-	-	-	-	-
MKMBIGCO_01116	2.03e-121	-	-	-	-	-	-	-	-
MKMBIGCO_01120	4.94e-54	-	-	-	S	-	-	-	Protein of unknown function (DUF2568)
MKMBIGCO_01121	2.61e-11	-	-	-	T	-	-	-	Histidine kinase
MKMBIGCO_01122	3.42e-09	-	-	-	D	-	-	-	nuclear chromosome segregation
MKMBIGCO_01123	2.33e-263	mrjp	-	-	G	-	-	-	Major royal jelly protein
MKMBIGCO_01124	8.98e-316	xynP	-	-	G	ko:K03292	-	ko00000	MFS/sugar transport protein
MKMBIGCO_01125	0.0	xynB	3.2.1.37	GH43	G	ko:K01198	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
MKMBIGCO_01126	1.54e-269	xylR	-	-	GK	-	-	-	ROK family
MKMBIGCO_01127	0.0	xylA	5.3.1.5	-	G	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko01000	Belongs to the xylose isomerase family
MKMBIGCO_01128	0.0	xylB	2.7.1.17	-	G	ko:K00854	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	xylulose kinase
MKMBIGCO_01129	0.0	pps	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	phosphoenolpyruvate synthase
MKMBIGCO_01134	1.45e-23	-	-	-	-	-	-	-	-
MKMBIGCO_01135	4.59e-155	yobV	-	-	K	-	-	-	WYL domain
MKMBIGCO_01136	6.73e-87	dinB	-	-	S	-	-	-	DinB family
MKMBIGCO_01137	1.15e-234	adhP	1.1.1.1	-	C	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
MKMBIGCO_01140	7.18e-184	yoaP	-	-	K	-	-	-	YoaP-like
MKMBIGCO_01141	3.28e-128	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_01142	7.6e-150	-	-	-	S	-	-	-	Domain of unknown function (DUF3885)
MKMBIGCO_01143	4.65e-255	-	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_01144	1.65e-152	-	-	AA10,CBM73	S	ko:K03933	-	ko00000	Pfam:Chitin_bind_3
MKMBIGCO_01145	9.28e-07	-	-	-	S	-	-	-	Protein of unknown function (Tiny_TM_bacill)
MKMBIGCO_01147	1.06e-123	yvgO	-	-	-	-	-	-	-
MKMBIGCO_01149	0.0	yobO	-	-	M	-	-	-	Pectate lyase superfamily protein
MKMBIGCO_01150	1.74e-101	yncF	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Deoxyuridine 5'-triphosphate
MKMBIGCO_01151	1.79e-178	yndL	-	-	S	-	-	-	Replication protein
MKMBIGCO_01152	8.63e-12	-	-	-	-	-	-	-	-
MKMBIGCO_01153	4.43e-185	-	-	-	O	-	-	-	COG0330 Membrane protease subunits, stomatin prohibitin homologs
MKMBIGCO_01154	7.53e-94	yndM	-	-	S	-	-	-	Protein of unknown function (DUF2512)
MKMBIGCO_01156	3.18e-141	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKMBIGCO_01157	1.01e-67	yneA	-	-	D	-	-	-	Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery
MKMBIGCO_01158	5.22e-145	yneB	-	-	L	-	-	-	resolvase
MKMBIGCO_01159	2.33e-43	ynzC	-	-	S	-	-	-	UPF0291 protein
MKMBIGCO_01160	0.0	tkt	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKMBIGCO_01161	5.14e-105	yneE	-	-	S	-	-	-	Sporulation inhibitor of replication protein sirA
MKMBIGCO_01162	6.2e-39	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
MKMBIGCO_01163	1.97e-33	ynzD	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
MKMBIGCO_01164	4.47e-164	ccdA	-	-	O	ko:K06196	-	ko00000,ko02000	cytochrome c biogenesis protein
MKMBIGCO_01165	1.43e-75	ccdB	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
MKMBIGCO_01166	7.59e-97	yneJ	-	-	O	-	-	-	COG4846 Membrane protein involved in cytochrome C biogenesis
MKMBIGCO_01167	1.97e-97	yneK	-	-	S	-	-	-	Protein of unknown function (DUF2621)
MKMBIGCO_01168	2.44e-82	cotM	-	-	O	ko:K06335	-	ko00000	Spore coat protein
MKMBIGCO_01169	1.97e-27	sspP	-	-	S	ko:K06433	-	ko00000	Belongs to the SspP family
MKMBIGCO_01170	6.2e-22	sspO	-	-	S	ko:K06432	-	ko00000	Belongs to the SspO family
MKMBIGCO_01171	0.0	citB	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MKMBIGCO_01172	3.46e-120	yneN	-	-	CO	-	-	-	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKMBIGCO_01174	1e-43	tlp	-	-	S	ko:K06434	-	ko00000	Belongs to the Tlp family
MKMBIGCO_01175	2.94e-97	yneP	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
MKMBIGCO_01176	3.18e-69	yneQ	-	-	-	-	-	-	-
MKMBIGCO_01177	3.13e-65	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
MKMBIGCO_01178	7.46e-120	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
MKMBIGCO_01179	9.94e-90	yneT	-	-	S	ko:K06929	-	ko00000	CoA-binding protein
MKMBIGCO_01180	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MKMBIGCO_01181	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
MKMBIGCO_01182	3.14e-19	-	-	-	-	-	-	-	-
MKMBIGCO_01183	1.82e-63	ynfC	-	-	-	-	-	-	-
MKMBIGCO_01184	0.0	alsT	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
MKMBIGCO_01185	1.29e-230	kdgK	2.7.1.45	-	G	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0524 Sugar kinases, ribokinase family
MKMBIGCO_01186	8.49e-242	yjmD	1.1.1.380	-	E	ko:K08322	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
MKMBIGCO_01187	1.51e-146	kdgA	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	2-dehydro-3-deoxy-phosphogluconate aldolase
MKMBIGCO_01188	1.8e-267	uxuA	4.2.1.8	-	G	ko:K01686	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the dehydration of D-mannonate
MKMBIGCO_01189	6.56e-188	yjmF	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_01190	1.96e-228	regR	-	-	K	ko:K02525	-	ko00000,ko03000	transcriptional
MKMBIGCO_01191	1.98e-280	exuT	-	-	G	ko:K08191,ko:K08194	-	ko00000,ko02000	Sugar (and other) transporter
MKMBIGCO_01192	6.68e-198	yndG	-	-	S	-	-	-	DoxX-like family
MKMBIGCO_01193	2.35e-101	-	-	-	S	-	-	-	Domain of unknown function (DUF4166)
MKMBIGCO_01194	0.0	yndJ	-	-	S	-	-	-	YndJ-like protein
MKMBIGCO_01195	1.36e-73	-	-	-	S	-	-	-	Platelet-activating factor acetylhydrolase, isoform II
MKMBIGCO_01196	5.59e-97	-	-	-	S	-	-	-	Platelet-activating factor acetylhydrolase, isoform II
MKMBIGCO_01197	0.0	bglC5	3.2.1.4	GH5,GH9	G	ko:K01179	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	PFAM glycoside hydrolase family 5
MKMBIGCO_01198	2.03e-67	yvlA	-	-	S	-	-	-	Domain of unknown function (DUF4870)
MKMBIGCO_01199	1.04e-306	-	-	-	T	-	-	-	Histidine kinase
MKMBIGCO_01200	8.54e-161	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
MKMBIGCO_01201	2.95e-316	ynfF	3.2.1.136	GH5	G	ko:K15924	-	ko00000,ko01000	Glycosyl hydrolase family 30 beta sandwich domain
MKMBIGCO_01202	0.0	xynD	3.2.1.55	CBM6,GH43	G	ko:K15921	ko00520,map00520	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
MKMBIGCO_01203	0.0	-	-	-	Q	ko:K15662,ko:K15663	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01204	0.0	-	-	-	Q	ko:K15662,ko:K15663	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01205	0.0	nrsA	-	-	Q	ko:K15661	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01206	9.43e-279	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_01207	3.23e-175	yxjF	1.1.1.30	-	IQ	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetoacetate from 3-hydroxybutyrate
MKMBIGCO_01208	4.5e-157	scoB	2.8.3.5	-	I	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MKMBIGCO_01209	2.56e-161	scoA	2.8.3.5	-	I	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MKMBIGCO_01210	0.0	yxjC	-	-	EG	-	-	-	COG2610 H gluconate symporter and related permeases
MKMBIGCO_01211	6.35e-276	bioI	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MKMBIGCO_01212	3.22e-246	bioB	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MKMBIGCO_01213	4.14e-164	bioD	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MKMBIGCO_01214	4.42e-270	bioF	2.3.1.29, 2.3.1.47	-	H	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
MKMBIGCO_01215	0.0	bioA	2.6.1.105, 2.6.1.62	-	H	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
MKMBIGCO_01216	5.24e-183	bioW	6.2.1.14	-	H	ko:K01906	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MKMBIGCO_01217	7e-90	yngA	-	-	S	-	-	-	membrane
MKMBIGCO_01218	4.67e-202	yngB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
MKMBIGCO_01219	5.33e-135	yngC	-	-	S	-	-	-	SNARE associated Golgi protein
MKMBIGCO_01220	0.0	yngE	-	-	I	-	-	-	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MKMBIGCO_01221	3.01e-179	yngF	-	-	I	-	-	-	Belongs to the enoyl-CoA hydratase isomerase family
MKMBIGCO_01222	1.36e-211	yngG	4.1.3.4	-	E	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA lyase
MKMBIGCO_01223	2.77e-41	-	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	Biotin carboxyl carrier protein
MKMBIGCO_01224	0.0	yngH	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Biotin carboxylase
MKMBIGCO_01225	0.0	yngI	-	-	IQ	ko:K00666	-	ko00000,ko01000,ko01004	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MKMBIGCO_01226	1.08e-267	yngJ	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
MKMBIGCO_01227	0.0	yngK	-	-	T	-	-	-	Glycosyl hydrolase-like 10
MKMBIGCO_01228	1.38e-84	yngL	-	-	S	-	-	-	Protein of unknown function (DUF1360)
MKMBIGCO_01229	0.0	-	-	-	Q	ko:K15656,ko:K15668	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	D-alanine [D-alanyl carrier protein] ligase activity
MKMBIGCO_01230	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01232	1.13e-93	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKMBIGCO_01233	4.27e-77	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
MKMBIGCO_01234	3.05e-199	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MKMBIGCO_01235	4.91e-190	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MKMBIGCO_01236	2.77e-178	ecfT	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MKMBIGCO_01237	1.69e-179	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
MKMBIGCO_01238	6.54e-102	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MKMBIGCO_01239	8.64e-84	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
MKMBIGCO_01240	2.92e-184	ybaJ	-	-	Q	-	-	-	Methyltransferase domain
MKMBIGCO_01241	7.43e-107	yizA	-	-	S	-	-	-	Damage-inducible protein DinB
MKMBIGCO_01242	3.1e-101	ybaK	-	-	S	-	-	-	Protein of unknown function (DUF2521)
MKMBIGCO_01243	1.98e-173	cwlD	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MKMBIGCO_01244	6.33e-254	mrp	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
MKMBIGCO_01245	1.95e-102	gerD	-	-	-	ko:K06294	-	ko00000	-
MKMBIGCO_01246	1.78e-134	kbaA	-	-	S	ko:K06349	-	ko00000	Involved in the activation of the KinB signaling pathway of sporulation
MKMBIGCO_01247	5.03e-180	pdaB	-	-	G	-	-	-	Polysaccharide deacetylase
MKMBIGCO_01251	0.0	-	-	-	Q	ko:K15664,ko:K15666,ko:K15667	ko01054,map01054	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01253	1.13e-53	-	-	-	S	-	-	-	COG NOG14552 non supervised orthologous group
MKMBIGCO_01254	5.02e-151	-	-	-	L	ko:K07497	-	ko00000	Molecular Function DNA binding, Biological Process DNA recombination
MKMBIGCO_01259	3.96e-54	-	-	-	L	-	-	-	transposase activity
MKMBIGCO_01260	1.04e-55	-	-	-	S	-	-	-	MazG-like family
MKMBIGCO_01261	1.98e-309	-	-	-	L	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
MKMBIGCO_01262	7.92e-188	-	-	-	L	-	-	-	AAA domain
MKMBIGCO_01263	9.96e-167	-	-	-	L	-	-	-	AAA domain
MKMBIGCO_01264	3.53e-231	-	-	-	S	-	-	-	Fusaric acid resistance protein-like
MKMBIGCO_01265	1.7e-236	pucA	1.17.1.4	-	O	ko:K00087,ko:K07402	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MKMBIGCO_01266	9.4e-113	pucB	1.17.1.4, 2.7.7.76	-	S	ko:K00087,ko:K07141	ko00230,ko00790,ko01100,ko01120,map00230,map00790,map01100,map01120	ko00000,ko00001,ko00002,ko01000	MobA-like NTP transferase domain
MKMBIGCO_01267	0.0	-	-	-	C	-	-	-	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs
MKMBIGCO_01268	7.45e-195	-	-	-	C	-	-	-	COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs
MKMBIGCO_01269	2.85e-109	pucE	1.2.5.3	-	C	ko:K03518	-	ko00000,ko01000	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs
MKMBIGCO_01270	0.0	fbp	3.1.3.11	-	G	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Firmicute fructose-1,6-bisphosphatase
MKMBIGCO_01271	4.32e-313	aapA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_01272	0.0	ahpF	-	-	O	ko:K03387	-	ko00000,ko01000	Alkyl hydroperoxide reductase
MKMBIGCO_01273	1.61e-136	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	Alkyl hydroperoxide reductase
MKMBIGCO_01274	5.02e-158	-	-	-	E	-	-	-	Ring-cleavage extradiol dioxygenase
MKMBIGCO_01275	7.8e-97	yxaI	-	-	S	-	-	-	membrane protein domain
MKMBIGCO_01276	3.64e-254	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
MKMBIGCO_01277	9.97e-67	arsR3	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MKMBIGCO_01278	1.02e-84	-	-	-	S	-	-	-	Family of unknown function (DUF5391)
MKMBIGCO_01279	1.45e-190	yxaL	-	-	S	-	-	-	PQQ-like domain
MKMBIGCO_01280	9.34e-317	aldX	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MKMBIGCO_01281	1.22e-271	yxbF	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MKMBIGCO_01282	1.38e-252	des	1.14.19.23, 1.14.19.45	-	I	ko:K10255	ko02020,map02020	ko00000,ko00001,ko01000,ko01004	fatty acid desaturase
MKMBIGCO_01283	4.8e-254	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_01284	1.07e-131	desR	-	-	T	ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_01285	2.92e-193	yxbG	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MKMBIGCO_01287	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Molecular chaperone. Has ATPase activity
MKMBIGCO_01288	6.38e-313	csbC	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MKMBIGCO_01289	3.94e-221	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
MKMBIGCO_01290	1.75e-174	iolR	-	-	K	ko:K06608,ko:K11534	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MKMBIGCO_01291	0.0	iolA	1.2.1.18, 1.2.1.27	-	C	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MKMBIGCO_01292	1.15e-198	iolB	5.3.1.30	-	G	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate)
MKMBIGCO_01293	3.82e-229	iolC	2.7.1.92	-	G	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)
MKMBIGCO_01294	0.0	iolD	3.7.1.22	-	E	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG)
MKMBIGCO_01295	3.12e-221	iolE	4.2.1.44	-	H	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	ko00000,ko00001,ko01000	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol)
MKMBIGCO_01296	5.22e-294	iolF	-	-	EGP	ko:K06610	-	ko00000,ko02000	Major facilitator superfamily
MKMBIGCO_01297	4.97e-248	iolG	1.1.1.18, 1.1.1.369	-	S	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively
MKMBIGCO_01298	6.24e-212	iolH	-	-	G	ko:K06605	-	ko00000	Xylose isomerase-like TIM barrel
MKMBIGCO_01299	6.94e-200	iolI	5.3.99.11	-	G	ko:K06606	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Involved in the reversible interconverion of 2-keto-myo- inositol (2KMI, inosose or 2,4,6 3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5 4,6- pentahydroxycyclohexanone)
MKMBIGCO_01300	5.25e-200	fbaA	4.1.2.13, 4.1.2.29	-	F	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)
MKMBIGCO_01301	9.37e-159	yxdJ	-	-	T	ko:K11634	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_01302	6.53e-223	yxdK	2.7.13.3	-	T	ko:K11633	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_01303	1.89e-181	yxdL	-	-	V	ko:K11635	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_01304	0.0	yxdM	-	-	V	ko:K11636	ko02020,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MKMBIGCO_01305	4.9e-76	yxeA	-	-	S	-	-	-	Protein of unknown function (DUF1093)
MKMBIGCO_01306	1.75e-229	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
MKMBIGCO_01307	6.55e-45	-	-	-	-	-	-	-	-
MKMBIGCO_01308	5.09e-35	yxeD	-	-	-	-	-	-	-
MKMBIGCO_01309	3.81e-33	yxeE	-	-	-	-	-	-	-
MKMBIGCO_01312	5.46e-192	yxeH	-	-	S	-	-	-	hydrolases of the HAD superfamily
MKMBIGCO_01313	8.24e-220	deoR	-	-	K	ko:K05346	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MKMBIGCO_01314	4.09e-145	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MKMBIGCO_01315	4.04e-265	nupC	-	-	F	ko:K11535	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKMBIGCO_01316	4.49e-296	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	phosphorylase
MKMBIGCO_01317	0.0	hutM	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MKMBIGCO_01318	2.78e-224	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide
MKMBIGCO_01319	7.16e-296	hutI	3.5.2.7	-	Q	ko:K01468	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Imidazolone-5-propionate hydrolase
MKMBIGCO_01320	0.0	hutU	4.2.1.49	-	E	ko:K01712	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MKMBIGCO_01321	0.0	hutH	4.3.1.3	-	E	ko:K01745	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	Histidine ammonia-lyase
MKMBIGCO_01322	2.45e-103	hutP	-	-	K	ko:K09683	-	ko00000,ko03000	Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization
MKMBIGCO_01323	0.0	yxiA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
MKMBIGCO_01324	2.39e-85	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MKMBIGCO_01325	0.0	-	-	-	L	-	-	-	HKD family nuclease
MKMBIGCO_01326	8.5e-95	yxiE	-	-	T	-	-	-	Belongs to the universal stress protein A family
MKMBIGCO_01327	1.46e-208	yxxF	-	-	EG	-	-	-	EamA-like transporter family
MKMBIGCO_01328	6.09e-254	pelB	4.2.2.10, 4.2.2.2	-	G	ko:K01728,ko:K01732	ko00040,ko02024,map00040,map02024	ko00000,ko00001,ko01000	Pectate lyase
MKMBIGCO_01329	0.0	wapA	-	-	M	-	-	-	COG3209 Rhs family protein
MKMBIGCO_01330	4.13e-148	-	-	-	-	-	-	-	-
MKMBIGCO_01331	2.51e-109	-	-	-	S	-	-	-	Protein of unknown function (DUF4240)
MKMBIGCO_01333	1.3e-81	yxxG	-	-	-	-	-	-	-
MKMBIGCO_01334	2.09e-91	yxiG	-	-	-	-	-	-	-
MKMBIGCO_01338	2.73e-100	-	-	-	-	-	-	-	-
MKMBIGCO_01340	2.28e-12	yxiJ	-	-	S	-	-	-	YxiJ-like protein
MKMBIGCO_01341	4.79e-27	-	-	-	-	-	-	-	-
MKMBIGCO_01342	8.09e-63	yxiI	-	-	S	-	-	-	Protein of unknown function (DUF2716)
MKMBIGCO_01343	4.09e-80	-	-	-	S	-	-	-	SMI1-KNR4 cell-wall
MKMBIGCO_01346	0.0	dbpA	3.6.4.13	-	JKL	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
MKMBIGCO_01347	4.76e-278	yxiO	-	-	S	ko:K06902	ko04138,map04138	ko00000,ko00001,ko02000,ko04131	COG2270 Permeases of the major facilitator superfamily
MKMBIGCO_01348	3.1e-27	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MKMBIGCO_01349	8.48e-137	licT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MKMBIGCO_01351	9.11e-182	bglS	-	-	M	-	-	-	licheninase activity
MKMBIGCO_01352	1.57e-281	citH	-	-	C	ko:K03300,ko:K11639	ko02020,map02020	ko00000,ko00001	Citrate transporter
MKMBIGCO_01353	0.0	katE	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MKMBIGCO_01354	3.38e-65	yxiS	-	-	-	-	-	-	-
MKMBIGCO_01355	9.35e-120	-	-	-	T	-	-	-	Domain of unknown function (DUF4163)
MKMBIGCO_01356	5.75e-267	nupG	-	-	F	ko:K16323	-	ko00000,ko02000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKMBIGCO_01357	9.82e-202	yxjB	2.1.1.187	-	Q	ko:K00563	-	ko00000,ko01000,ko03009	Methyltransferase domain
MKMBIGCO_01358	4.45e-275	yxjG	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Methionine synthase
MKMBIGCO_01359	1.75e-110	yxjI	-	-	S	-	-	-	LURP-one-related
MKMBIGCO_01362	5.46e-299	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
MKMBIGCO_01363	1.04e-246	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKMBIGCO_01364	2.68e-120	yxkC	-	-	S	-	-	-	Domain of unknown function (DUF4352)
MKMBIGCO_01365	3.28e-189	yxkD	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKMBIGCO_01366	2.25e-209	lrp	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
MKMBIGCO_01367	1.06e-260	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_01368	2.71e-197	yxkH	-	-	G	-	-	-	Polysaccharide deacetylase
MKMBIGCO_01369	5.53e-288	cimH	-	-	C	-	-	-	COG3493 Na citrate symporter
MKMBIGCO_01370	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
MKMBIGCO_01371	3.07e-239	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase, subunit II
MKMBIGCO_01372	0.0	cydC	-	-	V	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding
MKMBIGCO_01373	0.0	cydD	-	-	V	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ATP-binding protein
MKMBIGCO_01374	5.94e-199	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MKMBIGCO_01375	0.0	yxlA	-	-	F	ko:K03457	-	ko00000	Belongs to the purine-cytosine permease (2.A.39) family
MKMBIGCO_01376	1.59e-245	yxeI	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
MKMBIGCO_01377	0.0	katX	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MKMBIGCO_01378	1.07e-266	ydhT1	3.2.1.78	GH26	G	ko:K01218	ko00051,ko02024,map00051,map02024	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 26 family
MKMBIGCO_01379	5.28e-237	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MKMBIGCO_01380	2.85e-210	gmuE	2.7.1.4	-	GK	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	COG1940 Transcriptional regulator sugar kinase
MKMBIGCO_01381	0.0	ydhP	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MKMBIGCO_01382	1.41e-302	celB	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MKMBIGCO_01383	1.53e-63	ydhN3	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_01384	2.78e-65	ydhM	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_01385	1.48e-289	arsB	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKMBIGCO_01386	7.5e-76	arsR	-	-	K	ko:K03892,ko:K22043	-	ko00000,ko03000	transcriptional
MKMBIGCO_01387	5.34e-213	cbrA3	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein
MKMBIGCO_01388	1.38e-230	-	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_01389	3.3e-220	-	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_01390	4.59e-145	yxlJ	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
MKMBIGCO_01391	0.0	licR	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
MKMBIGCO_01392	4.46e-66	licB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	transporter subunit IIB
MKMBIGCO_01393	0.0	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MKMBIGCO_01394	1.18e-67	licA	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_01395	0.0	licH	3.2.1.86	GT4	G	ko:K01222	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	COG1486 Alpha-galactosidases 6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
MKMBIGCO_01396	9.09e-260	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
MKMBIGCO_01397	5.13e-288	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MKMBIGCO_01398	1.96e-49	dltC	6.1.1.13	-	IQ	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01399	2.56e-293	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	membrane protein involved in D-alanine export
MKMBIGCO_01400	0.0	dltA	6.1.1.13	-	Q	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_01401	7.08e-18	-	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
MKMBIGCO_01402	7.57e-215	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the MenA family. Type 1 subfamily
MKMBIGCO_01403	2.16e-150	ywaC	2.7.6.5	-	S	ko:K00951,ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	protein conserved in bacteria
MKMBIGCO_01404	1.42e-205	gspA	-	-	M	-	-	-	General stress
MKMBIGCO_01405	0.0	epr	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MKMBIGCO_01406	1.34e-314	licC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MKMBIGCO_01407	1.51e-87	ywbC	4.4.1.5	-	E	ko:K01759	ko00620,map00620	ko00000,ko00001,ko01000	glyoxalase
MKMBIGCO_01408	1.03e-284	ywbD	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	Methyltransferase
MKMBIGCO_01409	8.64e-176	mta	-	-	K	ko:K21743	-	ko00000,ko03000	transcriptional
MKMBIGCO_01410	9.1e-38	ywbE	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2196)
MKMBIGCO_01411	7.55e-143	ywbG	-	-	M	-	-	-	effector of murein hydrolase
MKMBIGCO_01412	3.67e-75	ywbH	-	-	S	ko:K06518	-	ko00000,ko02000	Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and or regulating their activity by a
MKMBIGCO_01413	4.83e-202	ywbI	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01414	3.2e-176	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MKMBIGCO_01415	3.35e-145	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
MKMBIGCO_01416	1.54e-309	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Dyp-type peroxidase family protein
MKMBIGCO_01417	1.21e-142	ywbO	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
MKMBIGCO_01418	3.31e-170	-	-	-	S	-	-	-	Streptomycin biosynthesis protein StrF
MKMBIGCO_01419	5.92e-165	-	-	-	H	-	-	-	Methionine biosynthesis protein MetW
MKMBIGCO_01421	5.07e-143	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
MKMBIGCO_01422	4.03e-80	gtcA	-	-	S	-	-	-	GtrA-like protein
MKMBIGCO_01423	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MKMBIGCO_01424	5.74e-48	ydaS	-	-	S	-	-	-	membrane
MKMBIGCO_01425	3.67e-227	qoxA	1.10.3.12	-	C	ko:K02826	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I
MKMBIGCO_01426	0.0	qoxB	1.10.3.12	-	C	ko:K02827	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKMBIGCO_01427	4.91e-144	qoxC	1.10.3.12	-	C	ko:K02828	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
MKMBIGCO_01428	1.31e-81	qoxD	1.10.3.12	-	C	ko:K02829	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	quinol oxidase, subunit
MKMBIGCO_01429	2.54e-51	ywcE	-	-	S	-	-	-	Required for proper spore morphogenesis. Important for spore germination
MKMBIGCO_01430	7.5e-100	ysnE	-	-	K	ko:K03829	-	ko00000,ko01000	acetyltransferase
MKMBIGCO_01431	1.58e-263	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
MKMBIGCO_01432	4.47e-176	nfrA1	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	Oxidoreductase
MKMBIGCO_01433	2.71e-235	ywcH	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_01434	0.0	prtS	3.4.21.110, 3.4.21.96	-	O	ko:K01361,ko:K08652,ko:K14647	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MKMBIGCO_01436	1.91e-195	sacT	-	-	K	ko:K03488	-	ko00000,ko03000	transcriptional antiterminator
MKMBIGCO_01437	0.0	sacP	2.7.1.211	-	G	ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_01438	0.0	sacA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
MKMBIGCO_01439	5e-26	ywdA	-	-	-	-	-	-	-
MKMBIGCO_01440	4.13e-187	pdxK	2.7.1.35, 2.7.1.49, 2.7.4.7	-	H	ko:K00868,ko:K00941	ko00730,ko00750,ko01100,map00730,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
MKMBIGCO_01441	1.6e-75	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
MKMBIGCO_01442	1.41e-115	ywdD	-	-	-	-	-	-	-
MKMBIGCO_01444	3.69e-189	ywdF	-	-	S	-	-	-	Glycosyltransferase like family 2
MKMBIGCO_01445	8.43e-170	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MKMBIGCO_01446	1.57e-62	ywdI	-	-	S	-	-	-	Family of unknown function (DUF5327)
MKMBIGCO_01447	1.26e-289	ywdJ	-	-	F	-	-	-	Xanthine uracil
MKMBIGCO_01448	2.17e-76	ywdK	-	-	S	-	-	-	small membrane protein
MKMBIGCO_01449	5.09e-85	gerQ	-	-	S	ko:K06305	-	ko00000	Essential for the localization of CwlJ in the spore coat and for spore germination triggered by calcium and dipicolinic acid (DPA). Its assembly into the spore coat is dependent on the coat morphogenetic proteins CotE and SpoIVA
MKMBIGCO_01450	7.44e-183	spsA	-	-	M	-	-	-	Spore Coat
MKMBIGCO_01451	0.0	spsB	-	-	M	-	-	-	Capsule polysaccharide biosynthesis protein
MKMBIGCO_01452	1.39e-279	spsC	2.6.1.102	-	E	ko:K13010	ko00520,map00520	ko00000,ko00001,ko01000,ko01005,ko01007	Belongs to the DegT DnrJ EryC1 family
MKMBIGCO_01453	1.02e-200	spsD	2.3.1.210	-	K	ko:K16704	-	ko00000,ko01000	Spore Coat
MKMBIGCO_01454	8.27e-273	pseI	2.5.1.56, 2.5.1.97	-	M	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	acid synthase
MKMBIGCO_01455	1.68e-170	spsF	-	-	M	ko:K07257	-	ko00000	Spore Coat
MKMBIGCO_01456	1.22e-227	spsG	-	-	M	-	-	-	Spore Coat
MKMBIGCO_01457	3.99e-177	spsI	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MKMBIGCO_01458	1.51e-232	spsJ	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
MKMBIGCO_01459	2.25e-206	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
MKMBIGCO_01460	1.15e-112	spsL	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Spore Coat
MKMBIGCO_01461	1.82e-76	-	-	-	-	-	-	-	-
MKMBIGCO_01462	3.15e-314	rocG	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MKMBIGCO_01463	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
MKMBIGCO_01464	0.0	rocB	-	-	E	-	-	-	arginine degradation protein
MKMBIGCO_01465	0.0	rocC	-	-	E	ko:K02205,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MKMBIGCO_01466	4.68e-263	tcaB	-	-	EGP	ko:K07552	-	ko00000,ko02000	-transporter
MKMBIGCO_01467	4.53e-283	ywfA	-	-	EGP	-	-	-	-transporter
MKMBIGCO_01468	1.4e-146	bacA	4.1.1.100	-	E	ko:K19546	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacA is an unusual prephenate decarboxylase that avoids the typical aromatization of the cyclohexadienol ring of prephenate. BacA catalyzes the protonation of prephenate (1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1- propanoic acid) at C6 position, followed by a decarboxylation to produce the endocyclic-delta(4),delta(8)-7R-dihydro- hydroxyphenylpyruvate (en-H2HPP). En-H2HPP is able to undergo a slow nonenzymatic isomerization to produce the exocyclic- delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP). BacA isomerizes only the pro-R double bond in prephenate
MKMBIGCO_01469	1.19e-176	bacB	5.3.3.19	-	S	ko:K19547	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the
MKMBIGCO_01470	1.56e-178	bacC	1.1.1.385	-	IQ	ko:K19548	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_01471	0.0	bacD	6.3.2.49	-	F	ko:K13037	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the formation of alpha-dipeptides from various L-amino acids in the presence of ATP. In vivo catalyzes the ligation of L-alanine and L-anticapsin (epoxycyclohexanonyl-Ala) to produce the final bacilysin antibiotic (L-Ala-L-4S-cyclohexenonyl-Ala dipeptide)
MKMBIGCO_01472	1.16e-264	bacE	-	-	EGP	ko:K19552	-	ko00000,ko02000	Part of the bacilysin biosynthesis operon. May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic
MKMBIGCO_01473	2.21e-297	ywfG	-	-	E	ko:K08969,ko:K19549	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
MKMBIGCO_01474	1.7e-180	ywfH	-	-	IQ	ko:K19550	ko01130,map01130	ko00000,ko00001,ko00002,ko01000	Enoyl-(Acyl carrier protein) reductase
MKMBIGCO_01475	4.87e-187	ywfI	-	-	C	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko01000	May function as heme-dependent peroxidase
MKMBIGCO_01476	2.03e-225	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	In Salmonella this enzyme is required for ethanolamine catabolism
MKMBIGCO_01477	3.42e-213	-	-	-	S	-	-	-	Conserved hypothetical protein 698
MKMBIGCO_01478	3.89e-211	cysL	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_01479	2.81e-198	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes
MKMBIGCO_01481	3.07e-224	-	-	-	-	-	-	-	-
MKMBIGCO_01484	1.4e-213	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter (permease)
MKMBIGCO_01485	2.61e-208	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_01486	4.41e-119	-	-	-	S	-	-	-	membrane
MKMBIGCO_01487	9.26e-69	-	-	-	K	ko:K10947	-	ko00000,ko03000	PadR family transcriptional regulator
MKMBIGCO_01488	7.1e-145	rsfA_1	-	-	-	ko:K06314	-	ko00000,ko03000	-
MKMBIGCO_01489	8.55e-49	ywzC	-	-	S	-	-	-	Belongs to the UPF0741 family
MKMBIGCO_01490	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	COG1078 HD superfamily phosphohydrolases
MKMBIGCO_01491	8.24e-115	ywgA	-	-	-	ko:K09388	-	ko00000	-
MKMBIGCO_01492	1.91e-313	potE5	-	-	E	ko:K03294	-	ko00000	C-terminus of AA_permease
MKMBIGCO_01493	9.43e-90	ywhA	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01494	2.37e-34	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	4-oxalocrotonate tautomerase
MKMBIGCO_01495	3.84e-153	ywhC	-	-	S	-	-	-	Peptidase family M50
MKMBIGCO_01496	2.16e-120	ywhD	-	-	S	-	-	-	YwhD family
MKMBIGCO_01497	2.9e-104	-	-	-	-	-	-	-	-
MKMBIGCO_01498	0.0	pbpG	2.4.1.129, 3.4.16.4	GT51	M	ko:K21464	ko00550,map00550	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MKMBIGCO_01499	1.58e-203	speE	2.5.1.16	-	E	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MKMBIGCO_01500	4.95e-214	speB	3.5.3.11	-	E	ko:K01480	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the arginase family
MKMBIGCO_01503	1.15e-98	-	-	-	CP	-	-	-	Membrane
MKMBIGCO_01505	9.48e-43	-	-	-	-	-	-	-	-
MKMBIGCO_01506	7.54e-40	ydcG	-	-	K	ko:K07729	-	ko00000,ko03000	sequence-specific DNA binding
MKMBIGCO_01508	2.01e-89	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MKMBIGCO_01509	4.79e-57	ywiB	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_01510	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
MKMBIGCO_01511	1.66e-270	narK	-	-	P	ko:K02575	ko00910,map00910	ko00000,ko00001,ko00002,ko02000	COG2223 Nitrate nitrite transporter
MKMBIGCO_01512	2.21e-166	fnr	-	-	K	-	-	-	helix_turn_helix, cAMP Regulatory protein
MKMBIGCO_01513	6.16e-178	ywiC	-	-	S	-	-	-	YwiC-like protein
MKMBIGCO_01514	1.38e-107	arfM	-	-	T	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	ko00000,ko00001,ko03000	cyclic nucleotide binding
MKMBIGCO_01515	0.0	narG	1.7.5.1	-	C	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MKMBIGCO_01516	0.0	narH	1.7.5.1	-	C	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase, beta
MKMBIGCO_01517	8.57e-122	narJ	-	-	C	ko:K00373	ko02020,map02020	ko00000,ko00001	nitrate reductase
MKMBIGCO_01518	1.56e-154	narI	1.7.5.1	-	C	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	ko00000,ko00001,ko00002,ko01000	Nitrate reductase (gamma
MKMBIGCO_01519	2.89e-134	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKMBIGCO_01520	0.0	ywiE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKMBIGCO_01521	0.0	ywjA	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
MKMBIGCO_01522	1.13e-58	ywjC	-	-	-	-	-	-	-
MKMBIGCO_01523	3.16e-232	uvsE	-	-	L	ko:K13281	-	ko00000,ko01000	Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion
MKMBIGCO_01524	2.84e-284	clsB	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the phospholipase D family. Cardiolipin synthase subfamily
MKMBIGCO_01525	0.0	ywjF	-	-	C	-	-	-	COG0247 Fe-S oxidoreductase
MKMBIGCO_01526	3.24e-73	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
MKMBIGCO_01527	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
MKMBIGCO_01528	7.8e-119	ywjG	-	-	S	-	-	-	Domain of unknown function (DUF2529)
MKMBIGCO_01529	1.07e-81	spo0F	-	-	T	ko:K02490	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG0784 FOG CheY-like receiver
MKMBIGCO_01530	5.51e-204	fbaA	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Aldolase
MKMBIGCO_01531	6.37e-144	tal	2.2.1.2	-	G	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKMBIGCO_01532	3.21e-303	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKMBIGCO_01533	1.43e-224	glpX	3.1.3.11	-	G	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	fructose-1,6-bisphosphatase
MKMBIGCO_01534	5.13e-304	rho	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MKMBIGCO_01535	7e-45	rpmE	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the 23S rRNA
MKMBIGCO_01536	4.76e-133	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
MKMBIGCO_01537	0.0	ykwA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
MKMBIGCO_01538	1.93e-200	ywkB	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
MKMBIGCO_01539	2.86e-121	racA	-	-	K	ko:K11686	-	ko00000,ko03036	Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure
MKMBIGCO_01540	1.51e-87	ywkD	-	-	E	ko:K08234	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MKMBIGCO_01541	1.11e-244	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MKMBIGCO_01542	1.29e-198	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
MKMBIGCO_01544	2.08e-79	ywlA	-	-	S	-	-	-	Uncharacterised protein family (UPF0715)
MKMBIGCO_01545	1.88e-152	spoIIR	-	-	S	ko:K06387	-	ko00000	stage II sporulation protein R
MKMBIGCO_01546	7.03e-98	ywlB	-	-	E	-	-	-	Belongs to the acetyltransferase family. ArgA subfamily
MKMBIGCO_01547	6.22e-243	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
MKMBIGCO_01548	3.91e-118	mntP	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MKMBIGCO_01549	1.2e-100	ywlE	3.1.3.48, 3.9.1.2	-	T	ko:K01104,ko:K20201	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKMBIGCO_01550	6.74e-106	rpiB	5.3.1.6	-	G	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase
MKMBIGCO_01551	7.42e-125	ywlG	-	-	S	-	-	-	Belongs to the UPF0340 family
MKMBIGCO_01552	5.69e-299	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKMBIGCO_01553	2.24e-147	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MKMBIGCO_01554	4.49e-80	atpI	-	-	S	ko:K02116	-	ko00000,ko00194	ATP synthase
MKMBIGCO_01555	5.19e-168	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
MKMBIGCO_01556	3.01e-36	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKMBIGCO_01557	1.66e-82	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MKMBIGCO_01558	1.95e-116	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKMBIGCO_01559	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MKMBIGCO_01560	1.1e-195	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKMBIGCO_01561	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MKMBIGCO_01562	8.24e-83	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
MKMBIGCO_01563	6.9e-116	ywmA	-	-	-	-	-	-	-
MKMBIGCO_01564	5.31e-44	ywzB	-	-	S	-	-	-	membrane
MKMBIGCO_01565	3.4e-174	ywmB	-	-	S	-	-	-	TATA-box binding
MKMBIGCO_01566	4.75e-304	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKMBIGCO_01567	6.71e-241	spoIID	-	-	D	ko:K06381	-	ko00000	Stage II sporulation protein D
MKMBIGCO_01568	1.36e-146	ywmC	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MKMBIGCO_01569	1.75e-157	ywmD	-	-	S	ko:K07114	-	ko00000,ko02000	protein containing a von Willebrand factor type A (vWA) domain
MKMBIGCO_01571	4.3e-185	fdhD	-	-	C	ko:K02379	-	ko00000	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MKMBIGCO_01572	2.18e-245	moaA	4.1.99.22	-	H	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	ko00000,ko00001,ko01000	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKMBIGCO_01573	6.28e-116	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
MKMBIGCO_01574	5e-106	ywmF	-	-	S	-	-	-	Peptidase M50
MKMBIGCO_01575	7.2e-18	csbD	-	-	K	-	-	-	CsbD-like
MKMBIGCO_01576	1.94e-66	ureA	3.5.1.5	-	E	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease gamma subunit family
MKMBIGCO_01577	8.83e-81	ureB	3.5.1.5	-	E	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	ko00000,ko00001,ko01000	Belongs to the urease beta subunit family
MKMBIGCO_01578	0.0	ureC	3.5.1.5	-	E	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
MKMBIGCO_01579	3.09e-88	ywnA	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01580	1.52e-156	xlnB	3.2.1.8	-	G	ko:K01181	-	ko00000,ko01000	Glycosyl hydrolases family 11
MKMBIGCO_01581	1.1e-76	ywnC	-	-	S	-	-	-	Family of unknown function (DUF5362)
MKMBIGCO_01582	0.0	ywnE	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKMBIGCO_01583	5.15e-90	ywnF	-	-	S	-	-	-	Family of unknown function (DUF5392)
MKMBIGCO_01585	2.76e-115	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	COG1247 Sortase and related acyltransferases
MKMBIGCO_01586	3.6e-186	spoIIQ	-	-	M	ko:K06386	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
MKMBIGCO_01587	5.45e-94	ywnJ	-	-	S	-	-	-	VanZ like family
MKMBIGCO_01588	4.76e-131	bcrC	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	COG0671 Membrane-associated phospholipid phosphatase
MKMBIGCO_01589	9.52e-264	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
MKMBIGCO_01590	1.29e-76	nrgB	-	-	K	ko:K04751	ko02020,map02020	ko00000,ko00001	Belongs to the P(II) protein family
MKMBIGCO_01591	1.32e-291	nrgA	-	-	P	ko:K03320	-	ko00000,ko02000	Ammonium transporter
MKMBIGCO_01592	1.13e-132	yjgF	-	-	Q	-	-	-	Isochorismatase family
MKMBIGCO_01593	8.05e-312	ywoD	-	-	EGP	-	-	-	Major facilitator superfamily
MKMBIGCO_01594	0.0	-	-	-	FH	ko:K03457,ko:K10975	-	ko00000,ko02000	COG1953 Cytosine uracil thiamine allantoin permeases
MKMBIGCO_01595	4.78e-271	ywoG	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_01596	1.46e-92	ywoH	-	-	K	-	-	-	transcriptional
MKMBIGCO_01597	5.93e-60	spoIIID	-	-	K	ko:K06283	-	ko00000,ko03000	Stage III sporulation protein D
MKMBIGCO_01598	1.75e-231	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein
MKMBIGCO_01599	2.09e-173	flhO	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
MKMBIGCO_01600	4.27e-184	flhP	-	-	N	ko:K02392	ko02040,map02040	ko00000,ko00001,ko02035	flagellar basal body
MKMBIGCO_01601	3.02e-254	rapD	-	-	S	ko:K06362	-	ko00000,ko01000	aspartate phosphatase
MKMBIGCO_01602	3.15e-98	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
MKMBIGCO_01603	1.87e-74	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
MKMBIGCO_01604	1.07e-89	ywpF	-	-	S	-	-	-	YwpF-like protein
MKMBIGCO_01605	4.49e-82	ywpG	-	-	-	-	-	-	-
MKMBIGCO_01606	1.47e-76	ssbB	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-stranded DNA-binding protein
MKMBIGCO_01607	1.18e-181	glcR	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
MKMBIGCO_01608	7.2e-200	ywpJ	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
MKMBIGCO_01609	0.0	ywqA	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
MKMBIGCO_01610	0.0	ywqB	-	-	S	-	-	-	SWIM zinc finger
MKMBIGCO_01611	1.74e-21	-	-	-	-	-	-	-	-
MKMBIGCO_01612	1.95e-149	ywqC	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
MKMBIGCO_01613	2.12e-155	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
MKMBIGCO_01614	2.05e-179	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	COG4464 Capsular polysaccharide biosynthesis protein
MKMBIGCO_01615	6.86e-311	ywqF	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MKMBIGCO_01616	1.26e-93	ywqG	-	-	S	-	-	-	Domain of unknown function (DUF1963)
MKMBIGCO_01617	4e-201	-	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01618	6.32e-122	ywqN	-	-	S	-	-	-	NAD(P)H-dependent
MKMBIGCO_01620	7.09e-113	ywrA	-	-	P	ko:K07240	-	ko00000,ko02000	COG2059 Chromate transport protein ChrA
MKMBIGCO_01621	2.84e-130	ywrB	-	-	P	ko:K07240	-	ko00000,ko02000	Chromate transporter
MKMBIGCO_01622	1.01e-109	ywrC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
MKMBIGCO_01623	0.0	ywrD	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
MKMBIGCO_01625	5.72e-144	ywrF	-	-	S	-	-	-	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKMBIGCO_01626	3.39e-25	-	-	-	-	-	-	-	-
MKMBIGCO_01627	5.34e-269	cotH	-	-	M	ko:K06330	-	ko00000	Spore Coat
MKMBIGCO_01628	6.63e-172	cotB	-	-	-	ko:K06325	-	ko00000	-
MKMBIGCO_01629	1.63e-161	ywrJ	-	-	-	-	-	-	-
MKMBIGCO_01630	4.73e-301	ywrK	-	-	P	ko:K03893	-	ko00000,ko02000	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKMBIGCO_01632	2.18e-214	alsR	-	-	K	-	-	-	LysR substrate binding domain
MKMBIGCO_01633	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
MKMBIGCO_01634	5.71e-191	budA	4.1.1.5	-	H	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
MKMBIGCO_01635	7.13e-123	ywrO	-	-	S	-	-	-	NADPH-quinone reductase (modulator of drug activity B)
MKMBIGCO_01636	1.44e-116	batE	-	-	T	-	-	-	Sh3 type 3 domain protein
MKMBIGCO_01637	2.32e-206	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	COG1879 ABC-type sugar transport system, periplasmic component
MKMBIGCO_01638	5.37e-205	rbsC	-	-	G	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MKMBIGCO_01639	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
MKMBIGCO_01640	7.65e-83	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
MKMBIGCO_01641	1.56e-198	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKMBIGCO_01642	4.99e-227	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
MKMBIGCO_01643	3.56e-260	gerKC	-	-	S	-	-	-	Spore germination B3/ GerAC like, C-terminal
MKMBIGCO_01644	5.98e-245	-	-	-	E	-	-	-	Spore germination protein
MKMBIGCO_01645	8.08e-245	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
MKMBIGCO_01646	3.44e-282	capB	-	-	M	ko:K01932	-	ko00000,ko01000	COG0769 UDP-N-acetylmuramyl tripeptide synthase
MKMBIGCO_01647	2.95e-91	capC	-	-	S	ko:K22116	-	ko00000	biosynthesis protein
MKMBIGCO_01648	2.7e-278	capA	-	-	M	ko:K07282	-	ko00000	enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
MKMBIGCO_01649	4.04e-29	ywtC	-	-	-	-	-	-	-
MKMBIGCO_01650	6.9e-298	pgdS	-	-	M	-	-	-	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
MKMBIGCO_01651	1.11e-72	yttA	-	-	S	-	-	-	Pfam Transposase IS66
MKMBIGCO_01652	1.77e-200	ywtE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolases of the HAD superfamily
MKMBIGCO_01653	2.3e-229	ywtF_2	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01654	8.17e-316	ywtG	-	-	U	ko:K02100,ko:K06609,ko:K08139	ko04113,map04113	ko00000,ko00001,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MKMBIGCO_01655	0.0	-	-	-	J	ko:K07011	-	ko00000	Glycosyl transferase family 2
MKMBIGCO_01656	9.21e-267	gerBC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination protein
MKMBIGCO_01657	4.98e-251	gerBB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
MKMBIGCO_01658	0.0	gerBA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
MKMBIGCO_01659	5.92e-235	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MKMBIGCO_01660	0.0	lytD	3.2.1.96	-	G	ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MKMBIGCO_01661	5.87e-276	tagB	2.7.8.44	-	M	ko:K21285	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKMBIGCO_01662	8.69e-182	tagA	2.4.1.187	GT26	M	ko:K05946	ko05111,map05111	ko00000,ko00001,ko01000,ko01003	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
MKMBIGCO_01663	2.69e-91	tagD	2.7.7.39	-	IM	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Cytidylyltransferase
MKMBIGCO_01664	0.0	-	-	-	M	-	-	-	Glycosyltransferase like family 2
MKMBIGCO_01665	0.0	tagF	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKMBIGCO_01666	5.06e-195	tagG	-	-	GM	ko:K09692	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
MKMBIGCO_01667	0.0	tagH	3.6.3.40	-	GM	ko:K09693	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system
MKMBIGCO_01668	2.64e-211	gtaB	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
MKMBIGCO_01669	8.19e-267	mnaA	5.1.3.14	-	M	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	ko00000,ko00001,ko00002,ko01000,ko01005	Belongs to the UDP-N-acetylglucosamine 2-epimerase family
MKMBIGCO_01670	4.48e-204	lytR	-	-	K	-	-	-	May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG)
MKMBIGCO_01671	1.86e-64	-	-	-	-	-	-	-	-
MKMBIGCO_01672	0.0	lytB	-	-	D	-	-	-	Stage II sporulation protein
MKMBIGCO_01673	0.0	lytC	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	n-acetylmuramoyl-L-alanine amidase
MKMBIGCO_01674	4.22e-151	tuaA	-	-	M	-	-	-	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MKMBIGCO_01675	0.0	tuaB	-	-	S	ko:K03328,ko:K16694,ko:K16695	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_01676	7.54e-284	tuaC	-	GT4	GM	ko:K16697	-	ko00000,ko01000,ko01003	Teichuronic acid
MKMBIGCO_01677	9.32e-317	tuaD	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MKMBIGCO_01678	0.0	tuaE	-	-	M	ko:K16705	-	ko00000	Teichuronic acid biosynthesis protein
MKMBIGCO_01679	3.49e-148	tuaF	-	-	M	ko:K16706	-	ko00000	protein involved in exopolysaccharide biosynthesis
MKMBIGCO_01680	2.82e-185	tuaG	-	GT2	M	ko:K16698	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
MKMBIGCO_01681	5.02e-298	tuaH	-	-	M	ko:K16699	-	ko00000,ko01000,ko01003	Teichuronic acid biosynthesis glycosyltransferase tuaH
MKMBIGCO_01682	3.12e-233	tagO	2.7.8.33, 2.7.8.35	-	M	ko:K02851	-	ko00000,ko01000,ko01003,ko01005	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase
MKMBIGCO_01683	2.21e-229	yvhJ	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01684	3.43e-154	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	Domain of unknown function (DUF1949)
MKMBIGCO_01685	1.4e-246	degS	2.7.13.3	-	T	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase
MKMBIGCO_01686	7.16e-163	degU	-	-	KT	ko:K02479,ko:K07692	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_01687	8.81e-204	degV	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_01688	0.0	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MKMBIGCO_01689	3.56e-57	comFB	-	-	S	ko:K02241	-	ko00000,ko00002,ko02044	Late competence development protein ComFB
MKMBIGCO_01690	6.79e-98	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Phosphoribosyl transferase domain
MKMBIGCO_01691	2.23e-97	yvyF	-	-	S	-	-	-	flagellar protein
MKMBIGCO_01692	6.14e-53	flgM	-	-	KNU	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	ko00000,ko00001,ko02035	Negative regulator of flagellin synthesis
MKMBIGCO_01693	2.2e-105	yvyG	-	-	NOU	-	-	-	FlgN protein
MKMBIGCO_01694	0.0	flgK	-	-	N	ko:K02396	ko02040,map02040	ko00000,ko00001,ko02035	flagellar hook-associated protein
MKMBIGCO_01695	1.4e-207	flgL	-	-	N	ko:K02397	ko02040,map02040	ko00000,ko00001,ko02035	Belongs to the bacterial flagellin family
MKMBIGCO_01696	2.8e-108	yviE	-	-	-	-	-	-	-
MKMBIGCO_01697	2.48e-96	fliW	-	-	S	ko:K13626	-	ko00000,ko02035	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MKMBIGCO_01698	2.67e-43	csrA	-	-	T	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	ko00000,ko00001,ko03019	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MKMBIGCO_01699	4.55e-153	hag	-	-	N	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	ko00000,ko00001,ko02035	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKMBIGCO_01700	0.0	fliD	-	-	N	ko:K02407	ko02040,map02040	ko00000,ko00001,ko02035	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MKMBIGCO_01701	5.79e-88	fliS	-	-	N	ko:K02422	ko02040,map02040	ko00000,ko00001,ko02035	flagellar protein FliS
MKMBIGCO_01702	3.08e-10	fliT	-	-	N	ko:K02423	ko02040,map02040	ko00000,ko00001,ko02035	bacterial-type flagellum organization
MKMBIGCO_01703	1.35e-89	-	-	-	-	-	-	-	-
MKMBIGCO_01704	3.94e-133	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKMBIGCO_01705	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
MKMBIGCO_01706	6.64e-233	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MKMBIGCO_01707	6.56e-190	yvjA	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_01708	3.08e-60	cccB	-	-	C	ko:K12263,ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
MKMBIGCO_01709	3.53e-158	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	cell division ATP-binding protein FtsE
MKMBIGCO_01710	8.56e-196	ftsX	-	-	D	ko:K09811	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation
MKMBIGCO_01711	4.04e-303	ywoF	-	-	P	-	-	-	Right handed beta helix region
MKMBIGCO_01712	0.0	ctpB	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
MKMBIGCO_01713	4.34e-67	swrA	-	-	S	-	-	-	Swarming motility protein
MKMBIGCO_01714	3.57e-281	minJ	-	-	O	-	-	-	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKMBIGCO_01715	1.98e-230	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
MKMBIGCO_01717	8.78e-34	-	-	-	Q	-	-	-	Thioesterase domain
MKMBIGCO_01718	1.66e-37	-	-	-	L	-	-	-	Transposase, Mutator family
MKMBIGCO_01719	9.55e-22	-	-	-	L	-	-	-	Transposase, Mutator family
MKMBIGCO_01720	4.48e-09	-	-	-	L	-	-	-	Transposase, Mutator family
MKMBIGCO_01721	3.42e-297	yvkA	-	-	P	-	-	-	-transporter
MKMBIGCO_01722	7.78e-143	yvkB	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01723	0.0	yvkC	2.7.9.2	-	GT	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphotransferase
MKMBIGCO_01724	2.59e-45	csbA	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_01725	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
MKMBIGCO_01726	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
MKMBIGCO_01727	8.07e-44	yvkN	-	-	-	-	-	-	-
MKMBIGCO_01728	4.87e-66	yvlA	-	-	-	-	-	-	-
MKMBIGCO_01729	9.16e-218	yvlB	-	-	S	-	-	-	Putative adhesin
MKMBIGCO_01730	8.1e-36	yvlC	-	-	KT	ko:K03973	-	ko00000,ko02048,ko03000	PspC domain
MKMBIGCO_01731	3.12e-65	yvlD	-	-	S	ko:K08972	-	ko00000	Membrane
MKMBIGCO_01732	0.0	yvnB	-	-	Q	-	-	-	Calcineurin-like phosphoesterase
MKMBIGCO_01733	1.73e-133	yxaF	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
MKMBIGCO_01734	4.29e-171	yvoA	-	-	K	ko:K03710	-	ko00000,ko03000	transcriptional
MKMBIGCO_01735	2.22e-172	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
MKMBIGCO_01736	7.52e-283	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MKMBIGCO_01737	3.62e-217	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MKMBIGCO_01738	8.74e-194	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MKMBIGCO_01739	1.35e-156	ppaX	3.6.1.1	-	S	ko:K06019	ko00190,map00190	ko00000,ko00001,ko01000	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool
MKMBIGCO_01740	8.08e-109	yvoF	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
MKMBIGCO_01741	8.4e-177	yvpB	-	-	NU	-	-	-	protein conserved in bacteria
MKMBIGCO_01742	2.45e-269	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MKMBIGCO_01743	1.76e-146	hisG	2.4.2.17	-	E	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
MKMBIGCO_01744	1.51e-296	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKMBIGCO_01745	3.35e-137	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
MKMBIGCO_01746	2.32e-146	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MKMBIGCO_01747	9.3e-167	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MKMBIGCO_01748	1.09e-173	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
MKMBIGCO_01749	4.7e-143	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	belongs to the PRA-CH family
MKMBIGCO_01750	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
MKMBIGCO_01751	3.3e-61	-	-	-	-	-	-	-	-
MKMBIGCO_01752	1.33e-156	mprA3	-	-	T	-	-	-	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_01753	1.85e-243	sasA	-	-	T	-	-	-	Histidine kinase
MKMBIGCO_01754	0.0	yvcD	-	-	S	-	-	-	COG0457 FOG TPR repeat
MKMBIGCO_01755	3.05e-203	spl	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	protein conserved in bacteria
MKMBIGCO_01756	3.13e-226	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
MKMBIGCO_01757	5.15e-113	yvcI	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
MKMBIGCO_01758	2.09e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
MKMBIGCO_01759	1.49e-224	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
MKMBIGCO_01760	1.04e-219	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
MKMBIGCO_01761	3.23e-49	crh	-	-	G	ko:K11184	-	ko00000	Phosphocarrier protein Chr
MKMBIGCO_01762	1.99e-183	yvcN	2.3.1.118	-	Q	ko:K00675	-	ko00000,ko01000	Belongs to the arylamine N-acetyltransferase family
MKMBIGCO_01765	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_01766	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_01767	0.0	-	-	-	Q	ko:K13612,ko:K13613	-	ko00000,ko01004,ko01008	Polyketide synthase of type I
MKMBIGCO_01768	0.0	-	1.6.5.5	-	C	ko:K00344	-	ko00000,ko01000	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MKMBIGCO_01769	1.98e-281	-	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MKMBIGCO_01770	1.45e-304	-	2.3.3.10	-	I	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01008	synthase
MKMBIGCO_01771	1.38e-174	-	-	-	I	ko:K15313	-	ko00000,ko01008	Belongs to the enoyl-CoA hydratase isomerase family
MKMBIGCO_01772	8.24e-185	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKMBIGCO_01773	3.63e-219	yqjP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MKMBIGCO_01774	2.39e-180	yqjQ	-	-	S	ko:K07124	-	ko00000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_01775	9.26e-317	dsdA	4.3.1.18	-	E	ko:K01753	ko00260,map00260	ko00000,ko00001,ko01000	Belongs to the serine threonine dehydratase family. DsdA subfamily
MKMBIGCO_01776	6.33e-227	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
MKMBIGCO_01777	7.67e-96	yqjT	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
MKMBIGCO_01779	1.18e-237	yueF	-	-	S	-	-	-	transporter activity
MKMBIGCO_01781	1.26e-73	-	-	-	S	-	-	-	YolD-like protein
MKMBIGCO_01782	7.74e-298	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKMBIGCO_01783	1.15e-114	yqjY	-	-	K	ko:K06977	-	ko00000	acetyltransferase
MKMBIGCO_01784	3.46e-80	yqjZ	-	-	S	-	-	-	enzyme involved in biosynthesis of extracellular polysaccharides
MKMBIGCO_01785	3.26e-220	yqkA	-	-	K	-	-	-	GrpB protein
MKMBIGCO_01786	5.4e-80	yqkB	-	-	S	-	-	-	Belongs to the HesB IscA family
MKMBIGCO_01787	7.88e-54	yqkC	-	-	S	-	-	-	Protein of unknown function (DUF2552)
MKMBIGCO_01788	5.57e-224	yqkD	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
MKMBIGCO_01789	5.53e-09	yqkE	-	-	S	-	-	-	Protein of unknown function (DUF3886)
MKMBIGCO_01790	8.51e-214	yqkF	-	-	C	-	-	-	oxidoreductases (related to aryl-alcohol dehydrogenases)
MKMBIGCO_01791	2.01e-10	-	-	-	S	-	-	-	Protein of unknown function (DUF3936)
MKMBIGCO_01792	1.04e-122	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
MKMBIGCO_01793	5.91e-280	yqxK	-	-	L	-	-	-	DNA helicase
MKMBIGCO_01794	4e-76	ansR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01795	1.3e-240	ansA	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	L-asparaginase
MKMBIGCO_01796	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Aspartate ammonia-lyase
MKMBIGCO_01797	1.19e-311	mleN	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
MKMBIGCO_01798	2.38e-309	mleA	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	malic enzyme
MKMBIGCO_01799	1.96e-30	-	-	-	-	-	-	-	-
MKMBIGCO_01800	7.29e-46	yqkK	-	-	-	-	-	-	-
MKMBIGCO_01802	1.01e-141	spoIIM	-	-	S	ko:K06384	-	ko00000	Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane
MKMBIGCO_01803	4.56e-104	fur	-	-	P	ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
MKMBIGCO_01804	9.51e-51	-	-	-	S	-	-	-	Protein of unknown function (DUF4227)
MKMBIGCO_01805	1.59e-213	xerD	-	-	L	ko:K04763	-	ko00000,ko03036	recombinase XerD
MKMBIGCO_01806	2.88e-293	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MKMBIGCO_01807	2.49e-189	punA	2.4.2.1, 2.4.2.28	-	F	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	ko00000,ko00001,ko00002,ko01000	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MKMBIGCO_01808	3.52e-273	dacF	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MKMBIGCO_01809	4e-76	spoIIAA	-	-	T	ko:K06378	-	ko00000	Belongs to the anti-sigma-factor antagonist family
MKMBIGCO_01810	4.77e-100	spoIIAB	2.7.11.1	-	F	ko:K06379	-	ko00000,ko01000	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition
MKMBIGCO_01811	6.81e-174	sigF	-	-	K	ko:K03091	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_01812	6.68e-143	spoVAA	-	-	S	ko:K06403	-	ko00000	Stage V sporulation protein AA
MKMBIGCO_01813	2.03e-78	spoVAB	-	-	S	ko:K06404	-	ko00000	Stage V sporulation protein AB
MKMBIGCO_01814	9.92e-104	spoVAC	-	-	S	ko:K06405	-	ko00000	stage V sporulation protein AC
MKMBIGCO_01815	5.53e-242	spoVAD	-	-	I	ko:K06406	-	ko00000	Stage V sporulation protein AD
MKMBIGCO_01816	2.15e-75	spoVAEB	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
MKMBIGCO_01817	7.55e-142	-	-	-	S	ko:K06407	-	ko00000	stage V sporulation protein
MKMBIGCO_01818	0.0	spoVAF	-	-	EG	ko:K06408	-	ko00000	Stage V sporulation protein AF
MKMBIGCO_01819	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
MKMBIGCO_01820	3.65e-198	ypuA	-	-	S	-	-	-	Secreted protein
MKMBIGCO_01821	4.12e-104	ppiB	5.2.1.8	-	O	ko:K01802,ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKMBIGCO_01822	5.79e-107	ccdC1	-	-	O	-	-	-	Protein of unknown function (DUF1453)
MKMBIGCO_01823	8.95e-129	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MKMBIGCO_01824	2.01e-70	ypuD	-	-	-	-	-	-	-
MKMBIGCO_01825	7.27e-266	ribD	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKMBIGCO_01826	3.97e-144	ribE	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin synthase
MKMBIGCO_01827	1.8e-291	ribBA	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKMBIGCO_01828	6.92e-106	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
MKMBIGCO_01829	2.74e-84	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MKMBIGCO_01830	4.02e-121	ypuF	-	-	S	ko:K09763	-	ko00000	Domain of unknown function (DUF309)
MKMBIGCO_01832	1.65e-163	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MKMBIGCO_01833	7.84e-133	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MKMBIGCO_01834	6.14e-122	ypuI	-	-	S	-	-	-	Protein of unknown function (DUF3907)
MKMBIGCO_01835	1.14e-275	dacB	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
MKMBIGCO_01836	5.33e-135	spmA	-	-	S	ko:K06373	-	ko00000	Spore maturation protein
MKMBIGCO_01837	8.99e-116	spmB	-	-	S	ko:K06374	-	ko00000	Spore maturation protein
MKMBIGCO_01838	1.49e-167	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
MKMBIGCO_01839	4.31e-128	resA	-	-	CO	-	-	-	Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c
MKMBIGCO_01840	0.0	resB	-	-	O	ko:K07399	-	ko00000	COG1333 ResB protein required for cytochrome c biosynthesis
MKMBIGCO_01841	6.24e-252	resC	-	-	O	-	-	-	'COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component'
MKMBIGCO_01842	9.77e-171	resD	-	-	T	ko:K07775	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_01843	0.0	resE	2.7.13.3	-	T	ko:K07651	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_01844	3.22e-135	sigX	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_01845	8.77e-244	rsiX	-	-	-	-	-	-	-
MKMBIGCO_01846	0.0	serA	1.1.1.399, 1.1.1.95	-	E	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKMBIGCO_01847	2.16e-122	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MKMBIGCO_01848	5.88e-55	fer	-	-	C	ko:K05337	-	ko00000	Ferredoxin
MKMBIGCO_01849	3.37e-250	ypbB	5.1.3.1	-	S	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	protein conserved in bacteria
MKMBIGCO_01850	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
MKMBIGCO_01851	1.4e-127	ypbD	-	-	S	ko:K07052	-	ko00000	metal-dependent membrane protease
MKMBIGCO_01852	1.59e-121	ypbE	-	-	M	-	-	-	Lysin motif
MKMBIGCO_01853	5.5e-111	ypbF	-	-	S	-	-	-	Protein of unknown function (DUF2663)
MKMBIGCO_01854	2.22e-187	ypbG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
MKMBIGCO_01855	3.35e-137	mecB	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MKMBIGCO_01856	1.81e-311	gudB	1.4.1.2	-	E	ko:K00260	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MKMBIGCO_01857	7.53e-239	ypdA	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	COG0492 Thioredoxin reductase
MKMBIGCO_01858	6.4e-156	prsW	-	-	S	-	-	-	Involved in the degradation of specific anti-sigma factors
MKMBIGCO_01859	2.09e-210	sleB	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Spore cortex-lytic enzyme
MKMBIGCO_01860	0.0	ypeB	-	-	H	ko:K06313	-	ko00000	sporulation protein
MKMBIGCO_01861	2.7e-76	ypfA	-	-	M	-	-	-	Flagellar protein YcgR
MKMBIGCO_01862	7.86e-18	-	-	-	S	-	-	-	Family of unknown function (DUF5359)
MKMBIGCO_01863	2.02e-146	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
MKMBIGCO_01864	8.14e-264	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
MKMBIGCO_01865	3.99e-236	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
MKMBIGCO_01866	1.87e-12	-	-	-	S	-	-	-	YpzI-like protein
MKMBIGCO_01867	8.44e-134	yphA	-	-	-	-	-	-	-
MKMBIGCO_01868	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
MKMBIGCO_01869	4.93e-244	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
MKMBIGCO_01870	3.25e-23	yphE	-	-	S	-	-	-	Protein of unknown function (DUF2768)
MKMBIGCO_01871	3.97e-172	yphF	-	-	-	-	-	-	-
MKMBIGCO_01872	0.0	spoIVA	-	-	S	ko:K06398	-	ko00000	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MKMBIGCO_01873	1.07e-57	hbs	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
MKMBIGCO_01874	6.27e-131	folE	3.5.4.16	-	H	ko:K01495	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase
MKMBIGCO_01875	6.23e-47	mtrB	-	-	K	ko:K06285	-	ko00000,ko03000	Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan
MKMBIGCO_01876	1.61e-176	hepS	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
MKMBIGCO_01877	7.76e-169	menG	2.1.1.163, 2.1.1.201	-	H	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)
MKMBIGCO_01878	2.29e-251	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
MKMBIGCO_01879	2.86e-102	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
MKMBIGCO_01880	3.4e-179	cheR	2.1.1.80	-	NT	ko:K00575	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko01000,ko02035	COG1352 Methylase of chemotaxis methyl-accepting proteins
MKMBIGCO_01881	9.75e-276	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MKMBIGCO_01882	1.06e-258	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MKMBIGCO_01883	2.93e-79	aroH	5.4.99.5	-	E	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis
MKMBIGCO_01884	0.0	trpE	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKMBIGCO_01885	5.32e-208	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKMBIGCO_01886	2.02e-168	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
MKMBIGCO_01887	1.68e-146	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
MKMBIGCO_01888	5.79e-289	trpB	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MKMBIGCO_01889	2.8e-187	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
MKMBIGCO_01890	1.5e-257	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKMBIGCO_01891	1.39e-257	tyrA	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	prephenate dehydrogenase
MKMBIGCO_01892	1.03e-303	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
MKMBIGCO_01893	2.15e-298	ypiA	-	-	S	-	-	-	COG0457 FOG TPR repeat
MKMBIGCO_01894	2.6e-129	ypiB	-	-	S	-	-	-	Belongs to the UPF0302 family
MKMBIGCO_01895	3.34e-101	ypiF	-	-	S	-	-	-	Protein of unknown function (DUF2487)
MKMBIGCO_01896	2.86e-127	qcrA	-	-	C	ko:K03886	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Menaquinol-cytochrome c reductase
MKMBIGCO_01897	8.76e-166	qcrB	-	-	C	ko:K03887	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	COG1290 Cytochrome b subunit of the bc complex
MKMBIGCO_01898	2.33e-190	qcrC	-	-	C	ko:K03888	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002	Menaquinol-cytochrome c reductase cytochrome b c subunit
MKMBIGCO_01899	2.17e-135	ypjA	-	-	S	-	-	-	membrane
MKMBIGCO_01900	1.96e-180	ypjB	-	-	S	-	-	-	sporulation protein
MKMBIGCO_01901	4.06e-289	-	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
MKMBIGCO_01902	4.31e-199	ypjC	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_01903	2.47e-74	ypjD	-	-	S	-	-	-	Nucleotide pyrophosphohydrolase
MKMBIGCO_01904	1.1e-188	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
MKMBIGCO_01905	6.19e-94	mgsA	4.2.3.3	-	G	ko:K01734	ko00640,ko01120,map00640,map01120	ko00000,ko00001,ko01000	methylglyoxal synthase
MKMBIGCO_01906	4.48e-170	bshB1	-	-	S	ko:K01463	-	ko00000,ko01000	proteins, LmbE homologs
MKMBIGCO_01907	2.55e-269	bshA	-	GT4	M	ko:K00754	-	ko00000,ko01000	N-acetyl-alpha-D-glucosaminyl L-malate synthase
MKMBIGCO_01908	7.21e-281	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MKMBIGCO_01909	5.22e-229	birA	6.3.4.15	-	K	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
MKMBIGCO_01910	8.63e-188	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
MKMBIGCO_01911	1.91e-200	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MKMBIGCO_01912	2.41e-84	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MKMBIGCO_01913	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
MKMBIGCO_01914	1.52e-32	ypmA	-	-	S	-	-	-	Protein of unknown function (DUF4264)
MKMBIGCO_01915	6.52e-103	ypmB	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_01916	5.7e-281	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MKMBIGCO_01917	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	asparaginyl-tRNA
MKMBIGCO_01918	3.42e-167	dnaD	-	-	L	ko:K02086	-	ko00000	DNA replication protein DnaD
MKMBIGCO_01919	1.7e-156	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKMBIGCO_01920	1.04e-118	ypoC	-	-	-	-	-	-	-
MKMBIGCO_01921	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MKMBIGCO_01922	7.27e-145	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
MKMBIGCO_01923	2e-239	yppC	-	-	S	-	-	-	Protein of unknown function (DUF2515)
MKMBIGCO_01924	0.000542	-	-	-	-	ko:K06430	-	ko00000	-
MKMBIGCO_01928	9.54e-81	yppG	-	-	S	-	-	-	YppG-like protein
MKMBIGCO_01929	7.23e-93	hspX	-	-	O	ko:K06335,ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MKMBIGCO_01930	9.93e-115	ypqE	-	-	G	ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	COG2190 Phosphotransferase system IIA components
MKMBIGCO_01931	0.0	yprA	-	-	L	ko:K06877	-	ko00000	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
MKMBIGCO_01932	1.85e-282	yprB	-	-	L	ko:K07502	-	ko00000	RNase_H superfamily
MKMBIGCO_01934	9.36e-48	cotD	-	-	S	ko:K06327	-	ko00000	Inner spore coat protein D
MKMBIGCO_01935	5.42e-128	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
MKMBIGCO_01936	5.52e-61	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
MKMBIGCO_01937	1.29e-273	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
MKMBIGCO_01938	6.91e-31	-	-	-	S	-	-	-	YpzG-like protein
MKMBIGCO_01940	0.0	ypvA	3.6.4.12	-	KL	ko:K03722	-	ko00000,ko01000,ko03400	COG1199 Rad3-related DNA helicases
MKMBIGCO_01941	0.0	ypwA	3.4.17.19	-	E	ko:K01299	-	ko00000,ko01000,ko01002	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MKMBIGCO_01942	8.16e-129	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
MKMBIGCO_01943	3.57e-298	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine
MKMBIGCO_01944	3.13e-176	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
MKMBIGCO_01945	1.63e-18	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MKMBIGCO_01946	6.12e-08	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
MKMBIGCO_01947	1.27e-43	-	-	-	-	-	-	-	-
MKMBIGCO_01948	2.33e-91	-	-	-	S	-	-	-	DNA binding
MKMBIGCO_01949	1.19e-112	-	-	-	-	-	-	-	-
MKMBIGCO_01953	5.31e-126	-	-	-	-	-	-	-	-
MKMBIGCO_01954	1.21e-78	pi112	-	-	L	-	-	-	PDDEXK-like domain of unknown function (DUF3799)
MKMBIGCO_01956	5.91e-100	yqaL	-	-	L	-	-	-	DnaD domain protein
MKMBIGCO_01957	1.11e-149	yqaM	-	-	L	-	-	-	IstB-like ATP binding protein
MKMBIGCO_01959	4.37e-76	rusA	-	-	L	-	-	-	Endodeoxyribonuclease RusA
MKMBIGCO_01961	1.85e-29	yqaO	-	-	S	-	-	-	Phage-like element PBSX protein XtrA
MKMBIGCO_01963	2.29e-07	-	-	-	-	-	-	-	-
MKMBIGCO_01965	3.03e-88	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MKMBIGCO_01969	2.95e-23	-	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_01972	4.94e-100	-	-	-	L	-	-	-	phage terminase small subunit
MKMBIGCO_01973	0.0	-	-	-	S	-	-	-	Terminase
MKMBIGCO_01974	2.47e-216	-	-	-	S	-	-	-	Phage portal protein
MKMBIGCO_01975	9.69e-105	-	-	-	S	-	-	-	peptidase activity
MKMBIGCO_01976	2.38e-200	-	-	-	S	-	-	-	capsid protein
MKMBIGCO_01977	2.8e-34	-	-	-	-	-	-	-	-
MKMBIGCO_01978	4.88e-51	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
MKMBIGCO_01979	6.9e-55	-	-	-	S	-	-	-	Phage head-tail joining protein
MKMBIGCO_01980	3.27e-64	-	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
MKMBIGCO_01982	1.39e-104	-	-	-	S	-	-	-	Phage tail tube protein
MKMBIGCO_01983	6.81e-06	-	-	-	-	-	-	-	-
MKMBIGCO_01984	0.0	-	-	-	D	-	-	-	phage tail tape measure protein
MKMBIGCO_01985	2.92e-129	-	-	-	S	-	-	-	Phage tail protein
MKMBIGCO_01986	9.28e-288	acm2	3.2.1.17	-	NU	ko:K01185	-	ko00000,ko01000	Prophage endopeptidase tail
MKMBIGCO_01987	0.0	-	-	-	S	-	-	-	Peptidase_G2, IMC autoproteolytic cleavage domain
MKMBIGCO_01988	2.99e-120	-	-	-	-	-	-	-	-
MKMBIGCO_01989	0.000763	-	-	-	-	-	-	-	-
MKMBIGCO_01990	4.85e-07	-	-	-	S	-	-	-	Phage uncharacterised protein (Phage_XkdX)
MKMBIGCO_01991	6.18e-74	-	-	-	S	-	-	-	Pfam:Phage_holin_4_1
MKMBIGCO_01992	1.72e-86	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	Ami_2
MKMBIGCO_01995	1.11e-104	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
MKMBIGCO_01997	1.94e-37	-	-	-	K	-	-	-	Helix-turn-helix domain
MKMBIGCO_01998	5.22e-91	-	-	-	S	-	-	-	Protein of unknown function (DUF3800)
MKMBIGCO_01999	4.67e-07	-	-	-	-	-	-	-	-
MKMBIGCO_02000	1.04e-128	yrdC	-	-	Q	-	-	-	Isochorismatase family
MKMBIGCO_02001	2.73e-42	ydfR	-	-	S	-	-	-	Protein of unknown function (DUF421)
MKMBIGCO_02002	1.78e-29	ydfR	-	-	S	-	-	-	Protein of unknown function (DUF421)
MKMBIGCO_02003	1.95e-07	-	-	-	S	-	-	-	Bacillus cereus group antimicrobial protein
MKMBIGCO_02004	1.17e-65	MGMT	-	-	L	ko:K07443	-	ko00000	6-O-methylguanine DNA methyltransferase, DNA binding domain
MKMBIGCO_02005	7.21e-136	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_02006	1.35e-263	bcsA	-	-	Q	ko:K16167	-	ko00000,ko01008	Naringenin-chalcone synthase
MKMBIGCO_02007	1.26e-117	ypbQ	-	-	S	ko:K16168	-	ko00000,ko01008	protein conserved in bacteria
MKMBIGCO_02008	0.0	ypbR	-	-	S	-	-	-	Dynamin family
MKMBIGCO_02009	1.17e-51	ypbS	-	-	S	-	-	-	Protein of unknown function (DUF2533)
MKMBIGCO_02010	2.44e-10	-	-	-	-	-	-	-	-
MKMBIGCO_02011	3.19e-208	ypcP	-	-	L	-	-	-	5'3' exonuclease
MKMBIGCO_02013	2.47e-88	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease
MKMBIGCO_02014	9.33e-153	ypdP	-	-	S	ko:K09125	-	ko00000	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MKMBIGCO_02015	8.39e-159	ypeP	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	COG0328 Ribonuclease HI
MKMBIGCO_02016	6.59e-40	ypeQ	-	-	S	-	-	-	Zinc-finger
MKMBIGCO_02017	1.13e-49	-	-	-	S	-	-	-	Protein of unknown function (DUF2564)
MKMBIGCO_02018	5.19e-17	degR	-	-	-	-	-	-	-
MKMBIGCO_02019	5.12e-42	cspD	-	-	K	ko:K03704	-	ko00000,ko03000	Cold-shock protein
MKMBIGCO_02020	9e-276	ugtP	2.4.1.315	GT28	M	ko:K03429	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)
MKMBIGCO_02021	2.3e-227	metAA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKMBIGCO_02022	1.08e-110	bsaA	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
MKMBIGCO_02023	3.97e-129	yagB	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
MKMBIGCO_02024	3.51e-200	ypgR	-	-	C	-	-	-	COG0694 Thioredoxin-like proteins and domains
MKMBIGCO_02025	0.0	ilvD	4.2.1.9	-	E	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the IlvD Edd family
MKMBIGCO_02026	4.8e-99	yphP	-	-	S	-	-	-	Belongs to the UPF0403 family
MKMBIGCO_02027	4.25e-173	ypiP	-	-	AJ	-	-	-	Putative SAM-dependent methyltransferase
MKMBIGCO_02028	9.2e-148	ypjP	-	-	S	-	-	-	YpjP-like protein
MKMBIGCO_02029	5.11e-203	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MKMBIGCO_02030	1.43e-115	dfrA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MKMBIGCO_02031	1.92e-147	ypkP	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MKMBIGCO_02032	5.24e-143	yplQ	-	-	S	ko:K11068	-	ko00000,ko02042	protein, Hemolysin III
MKMBIGCO_02033	1.59e-221	yplP	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_02034	8.57e-309	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MKMBIGCO_02035	5.02e-52	ypmP	-	-	S	-	-	-	Protein of unknown function (DUF2535)
MKMBIGCO_02036	5.97e-136	ypmQ	-	-	S	ko:K07152	-	ko00000,ko03029	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems
MKMBIGCO_02037	1.67e-172	ypmR	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
MKMBIGCO_02038	6.53e-125	ypmS	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02039	3.35e-89	ypoP	-	-	K	-	-	-	transcriptional
MKMBIGCO_02040	1.2e-133	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07304,ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKMBIGCO_02041	4.61e-106	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
MKMBIGCO_02042	1.98e-133	-	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MKMBIGCO_02043	0.0	yokA	-	-	L	-	-	-	Recombinase
MKMBIGCO_02046	2.03e-107	yokF	3.1.31.1	-	L	ko:K01174	-	ko00000,ko01000	RNA catabolic process
MKMBIGCO_02047	1.88e-112	-	-	-	G	-	-	-	SMI1-KNR4 cell-wall
MKMBIGCO_02048	0.0	-	-	-	L	ko:K21487	-	ko00000,ko01000,ko02048	A nuclease of the HNH/ENDO VII superfamily with conserved LHH
MKMBIGCO_02049	3.88e-68	-	-	-	S	ko:K21488	-	ko00000,ko02048	SMI1-KNR4 cell-wall
MKMBIGCO_02050	1.23e-113	yokK	-	-	S	-	-	-	SMI1 / KNR4 family
MKMBIGCO_02051	2.68e-39	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_02055	1.35e-96	-	-	-	S	-	-	-	amine dehydrogenase activity
MKMBIGCO_02056	8.57e-63	-	-	-	S	-	-	-	amine dehydrogenase activity
MKMBIGCO_02058	9.46e-226	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MKMBIGCO_02059	8.71e-23	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MKMBIGCO_02060	1.3e-99	yoqH	-	-	M	-	-	-	LysM domain
MKMBIGCO_02064	8.25e-29	ligB	6.5.1.1, 6.5.1.6, 6.5.1.7	-	L	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	ko00000,ko00001,ko01000,ko03032,ko03400	ATP-dependent DNA ligase
MKMBIGCO_02065	5.37e-101	-	-	-	-	-	-	-	-
MKMBIGCO_02071	3.54e-95	-	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MKMBIGCO_02072	7.47e-281	phy	3.1.3.8	-	I	ko:K01083	ko00562,map00562	ko00000,ko00001,ko01000	Myo-inositol-hexaphosphate 3-phosphohydrolase
MKMBIGCO_02073	1.21e-219	cgeB	-	-	S	ko:K06320	-	ko00000	Spore maturation protein
MKMBIGCO_02074	1.22e-87	cgeA	-	-	-	ko:K06319	-	ko00000	-
MKMBIGCO_02075	7.84e-61	cgeC	-	-	-	ko:K06321	-	ko00000	-
MKMBIGCO_02076	1.26e-306	cgeD	-	-	M	ko:K06322	-	ko00000	maturation of the outermost layer of the spore
MKMBIGCO_02077	3.3e-184	yiiD	-	-	K	ko:K06323	-	ko00000	acetyltransferase
MKMBIGCO_02079	8.35e-84	-	-	-	L	-	-	-	Bacterial transcription activator, effector binding domain
MKMBIGCO_02080	4.63e-310	yodT	-	-	H	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKMBIGCO_02081	9.76e-161	atoD	2.8.3.8, 2.8.3.9	-	I	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MKMBIGCO_02082	4.64e-160	atoA	2.8.3.8, 2.8.3.9	-	I	ko:K01035	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	ko00000,ko00001,ko01000	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit
MKMBIGCO_02083	0.0	yodQ	3.5.1.16, 3.5.1.18	-	E	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetylornithine deacetylase
MKMBIGCO_02084	1.71e-204	yodP	2.3.1.264	-	K	ko:K21935	-	ko00000,ko01000	Acetyltransferase (GNAT) family
MKMBIGCO_02085	0.0	kamA	5.4.3.2	-	E	ko:K01843	ko00310,map00310	ko00000,ko00001,ko01000	lysine 2,3-aminomutase
MKMBIGCO_02086	2.83e-62	yokU	-	-	S	-	-	-	YokU-like protein, putative antitoxin
MKMBIGCO_02087	2.02e-47	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
MKMBIGCO_02088	6.07e-37	-	-	-	E	-	-	-	lactoylglutathione lyase activity
MKMBIGCO_02089	1.9e-161	yodN	-	-	-	-	-	-	-
MKMBIGCO_02091	9.77e-34	yozD	-	-	S	-	-	-	YozD-like protein
MKMBIGCO_02092	1.76e-132	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
MKMBIGCO_02093	1.16e-72	yodL	-	-	S	-	-	-	YodL-like
MKMBIGCO_02095	1.05e-161	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
MKMBIGCO_02096	4.49e-192	yodJ	3.4.17.14	-	M	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-alanyl-D-alanine carboxypeptidase
MKMBIGCO_02097	2.5e-32	yodI	-	-	-	-	-	-	-
MKMBIGCO_02098	1.02e-164	yodH	-	-	Q	-	-	-	Methyltransferase
MKMBIGCO_02099	0.0	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
MKMBIGCO_02100	3.53e-169	yydK	-	-	K	ko:K03489	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02101	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MKMBIGCO_02102	0.0	-	3.2.1.45	GH30	M	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	ko00000,ko00001,ko01000	Glycosyl hydrolase family 30 beta sandwich domain
MKMBIGCO_02103	0.0	yodF	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKMBIGCO_02104	1.97e-28	-	-	-	S	-	-	-	Protein of unknown function (DUF3311)
MKMBIGCO_02105	2.2e-221	yodE	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MKMBIGCO_02106	2.84e-139	yahD	-	-	S	ko:K06999	-	ko00000	Carboxylesterase
MKMBIGCO_02107	1.35e-138	yodC	-	-	C	-	-	-	nitroreductase
MKMBIGCO_02108	2.42e-74	yodB	-	-	K	-	-	-	transcriptional
MKMBIGCO_02109	1.86e-90	yoaQ	-	-	S	-	-	-	Evidence 4 Homologs of previously reported genes of
MKMBIGCO_02110	2.13e-88	iolK	-	-	S	-	-	-	tautomerase
MKMBIGCO_02112	4.68e-104	yozR	-	-	S	-	-	-	COG0071 Molecular chaperone (small heat shock protein)
MKMBIGCO_02113	5.73e-208	rarD	-	-	S	ko:K05786	-	ko00000,ko02000	-transporter
MKMBIGCO_02114	1.05e-30	-	-	-	-	-	-	-	-
MKMBIGCO_02115	3.3e-79	yojF	-	-	S	-	-	-	Protein of unknown function (DUF1806)
MKMBIGCO_02116	9.11e-162	yojG	-	-	S	ko:K22135	-	ko00000,ko01000	deacetylase
MKMBIGCO_02117	5.03e-194	-	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MKMBIGCO_02118	7.01e-303	norM	-	-	V	ko:K03327	-	ko00000,ko02000	Multidrug efflux pump
MKMBIGCO_02120	4.69e-144	dacB	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MKMBIGCO_02121	1.11e-283	-	-	-	CG	-	-	-	UDP-glucoronosyl and UDP-glucosyl transferase
MKMBIGCO_02122	8.28e-291	-	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MKMBIGCO_02123	1.04e-141	sodC	1.15.1.1	-	P	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MKMBIGCO_02124	4.2e-209	yojN	-	-	S	ko:K04748	-	ko00000	ATPase family associated with various cellular activities (AAA)
MKMBIGCO_02125	0.0	yojO	-	-	P	-	-	-	Von Willebrand factor
MKMBIGCO_02126	0.0	odhA	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
MKMBIGCO_02127	7.41e-263	odhB	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
MKMBIGCO_02128	7.15e-177	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
MKMBIGCO_02129	7.77e-214	yocS	-	-	S	ko:K03453	-	ko00000	-transporter
MKMBIGCO_02130	5.92e-298	yocR	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MKMBIGCO_02131	1.59e-210	sodF	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Superoxide dismutase
MKMBIGCO_02132	0.0	sqhC	4.2.1.137	-	I	ko:K18115	-	ko00000,ko01000	COG1657 Squalene cyclase
MKMBIGCO_02133	0.0	dhaS	1.2.1.3, 1.2.1.39	-	C	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MKMBIGCO_02134	1.35e-42	yozC	-	-	-	-	-	-	-
MKMBIGCO_02136	5.32e-75	yozO	-	-	S	-	-	-	Bacterial PH domain
MKMBIGCO_02137	6.36e-50	yocN	-	-	-	-	-	-	-
MKMBIGCO_02138	9.63e-60	yozN	-	-	-	-	-	-	-
MKMBIGCO_02139	2.29e-116	yocM	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
MKMBIGCO_02141	2.71e-13	yocL	-	-	-	-	-	-	-
MKMBIGCO_02142	2.23e-79	yocK	-	-	T	-	-	-	general stress protein
MKMBIGCO_02144	2.32e-144	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKMBIGCO_02145	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	DNA helicase
MKMBIGCO_02146	2.62e-159	yocH	-	-	M	-	-	-	COG1388 FOG LysM repeat
MKMBIGCO_02148	6.44e-239	yocD	3.4.17.13	-	V	ko:K01297	-	ko00000,ko01000,ko01002,ko01011	peptidase S66
MKMBIGCO_02149	3.78e-122	yocC	-	-	-	-	-	-	-
MKMBIGCO_02150	2.38e-179	-	-	-	J	-	-	-	Protein required for attachment to host cells
MKMBIGCO_02151	1.33e-117	yozB	-	-	S	ko:K08976	-	ko00000	membrane
MKMBIGCO_02152	1.19e-157	yocA	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MKMBIGCO_02153	2.58e-71	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	transcriptional
MKMBIGCO_02154	1.57e-118	yobW	-	-	-	-	-	-	-
MKMBIGCO_02155	9.42e-173	yobT	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MKMBIGCO_02156	1.92e-119	yobS	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_02157	1.45e-170	yobQ	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
MKMBIGCO_02158	2.12e-70	csaA	-	-	J	ko:K06878	-	ko00000	tRNA-binding protein
MKMBIGCO_02159	7.06e-80	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
MKMBIGCO_02160	4.97e-168	ykvO	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
MKMBIGCO_02161	1.99e-58	-	-	-	-	-	-	-	-
MKMBIGCO_02162	6.1e-124	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_02163	0.0	yoaE	-	-	C	-	-	-	belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MKMBIGCO_02164	1.8e-247	yoaD	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKMBIGCO_02165	0.0	lsrK	2.7.1.189	-	G	ko:K11216	ko02024,map02024	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
MKMBIGCO_02166	4.46e-261	yoaB	-	-	EGP	-	-	-	the major facilitator superfamily
MKMBIGCO_02167	7.62e-170	yoxB	-	-	-	-	-	-	-
MKMBIGCO_02168	3.16e-52	-	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MKMBIGCO_02169	2.43e-157	fabG	1.1.1.100	-	S	ko:K00059,ko:K07124	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_02170	8.08e-79	rtp	-	-	K	-	-	-	Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat
MKMBIGCO_02171	3.42e-181	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKMBIGCO_02172	2.31e-258	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MKMBIGCO_02173	6.93e-204	gltC	-	-	K	ko:K09681	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02174	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	glutamate synthase
MKMBIGCO_02175	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
MKMBIGCO_02176	2.22e-233	yogA	-	-	C	ko:K13955	-	ko00000	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases
MKMBIGCO_02177	3.54e-197	gltR1	-	-	K	ko:K21959	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02178	3.18e-07	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MKMBIGCO_02179	3.29e-67	-	-	-	K	-	-	-	Helix-turn-helix domain
MKMBIGCO_02180	9.26e-254	-	-	-	EGP	ko:K08164	-	ko00000,ko02000	-transporter
MKMBIGCO_02181	0.0	ggt	2.3.2.2, 3.4.19.13	-	E	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	ko00000,ko00001,ko01000,ko01002	gamma-glutamyltransferase
MKMBIGCO_02182	6.69e-47	yoeD	-	-	G	-	-	-	Helix-turn-helix domain
MKMBIGCO_02183	3.97e-125	-	-	-	L	-	-	-	Integrase
MKMBIGCO_02185	5.86e-122	yoeB	-	-	S	-	-	-	IseA DL-endopeptidase inhibitor
MKMBIGCO_02186	1.75e-310	yoeA	-	-	V	-	-	-	MATE efflux family protein
MKMBIGCO_02187	1.52e-236	yoxA	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
MKMBIGCO_02188	0.0	dacC	3.4.16.4	-	M	ko:K07259	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
MKMBIGCO_02208	1.17e-49	-	-	-	C	-	-	-	Na+/H+ antiporter family
MKMBIGCO_02209	3.42e-167	ygaJ	3.4.13.21	-	E	ko:K05995	-	ko00000,ko01000,ko01002	Belongs to the peptidase S51 family
MKMBIGCO_02210	0.0	thiC	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MKMBIGCO_02211	0.0	ygaK	-	-	C	-	-	-	Berberine and berberine like
MKMBIGCO_02213	1.91e-292	oppA5	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	PFAM extracellular solute-binding protein family 5
MKMBIGCO_02214	8.51e-188	-	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MKMBIGCO_02215	8.8e-162	-	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_02216	3.14e-169	oppD3	-	-	P	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02217	9.42e-168	oppF9	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02218	0.0	katA	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	serves to protect cells from the toxic effects of hydrogen peroxide
MKMBIGCO_02219	8.69e-230	-	-	-	S	ko:K07045	-	ko00000	Amidohydrolase
MKMBIGCO_02220	4.31e-178	ssuB	-	-	P	ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component
MKMBIGCO_02221	5.85e-228	ssuA	-	-	M	ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Sulfonate ABC transporter
MKMBIGCO_02222	3.93e-184	ssuC	-	-	P	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MKMBIGCO_02223	1.74e-272	ssuD	1.14.14.28, 1.14.14.5	-	C	ko:K04091,ko:K20938	ko00920,map00920	ko00000,ko00001,ko01000	Catalyzes the desulfonation of aliphatic sulfonates
MKMBIGCO_02224	1.18e-55	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MKMBIGCO_02225	7.46e-106	ygaO	-	-	-	-	-	-	-
MKMBIGCO_02226	9.41e-32	-	-	-	K	ko:K07729	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02228	2.7e-138	yhzB	-	-	S	-	-	-	B3/4 domain
MKMBIGCO_02229	1.64e-284	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKMBIGCO_02230	1.64e-222	yhbB	-	-	S	-	-	-	Putative amidase domain
MKMBIGCO_02231	4.84e-112	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
MKMBIGCO_02232	1.14e-139	yhbD	-	-	K	-	-	-	Protein of unknown function (DUF4004)
MKMBIGCO_02233	3.25e-84	yhbE	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
MKMBIGCO_02234	3.13e-91	yhbF	-	-	M	-	-	-	COG1664 Integral membrane protein CcmA involved in cell shape determination
MKMBIGCO_02235	1.23e-07	-	-	-	-	-	-	-	-
MKMBIGCO_02236	0.0	prkA	-	-	T	ko:K07180	-	ko00000	Ser protein kinase
MKMBIGCO_02237	5.45e-279	yhbH	-	-	S	ko:K09786	-	ko00000	Belongs to the UPF0229 family
MKMBIGCO_02238	4.15e-98	yhbI	-	-	K	ko:K15973	-	ko00000,ko03000	DNA-binding transcription factor activity
MKMBIGCO_02239	1.54e-132	yhbJ	-	-	V	-	-	-	COG1566 Multidrug resistance efflux pump
MKMBIGCO_02240	0.0	yhcA	-	-	EGP	ko:K03446	-	ko00000,ko00002,ko02000	the major facilitator superfamily
MKMBIGCO_02241	9.09e-129	wrbA	1.6.5.2	-	S	ko:K03809	ko00130,ko01110,map00130,map01110	ko00000,ko00001,ko01000	NADPH-dependent FMN reductase
MKMBIGCO_02242	1.41e-72	yhcC	-	-	-	-	-	-	-
MKMBIGCO_02243	9.36e-66	-	-	-	-	-	-	-	-
MKMBIGCO_02244	1.35e-80	yhcF	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02245	2.32e-158	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_02246	9.59e-215	yhcH	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_02247	1.29e-208	yhcI	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
MKMBIGCO_02248	7.28e-42	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
MKMBIGCO_02249	1.09e-185	metQ_3	-	-	M	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
MKMBIGCO_02250	5.01e-235	yhcK	2.7.7.65	-	T	ko:K18967	-	ko00000,ko01000,ko02000	COG2199 FOG GGDEF domain
MKMBIGCO_02251	1e-305	tcyP	-	-	U	ko:K06956	-	ko00000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MKMBIGCO_02252	1.96e-77	yhcM	-	-	-	-	-	-	-
MKMBIGCO_02253	2.69e-122	yhcN	-	-	S	-	-	-	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MKMBIGCO_02254	1.68e-206	yhcP	-	-	-	-	-	-	-
MKMBIGCO_02255	7.38e-150	yhcQ	-	-	M	-	-	-	Spore coat protein
MKMBIGCO_02256	0.0	yhcR	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01081,ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
MKMBIGCO_02257	2.63e-136	yhcS	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	COG3764 Sortase (surface protein transpeptidase)
MKMBIGCO_02258	1.79e-213	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
MKMBIGCO_02259	1.88e-92	yhcU	-	-	S	-	-	-	Family of unknown function (DUF5365)
MKMBIGCO_02260	3.54e-90	yhcV	-	-	S	-	-	-	COG0517 FOG CBS domain
MKMBIGCO_02261	1.39e-160	yhcW	-	-	S	ko:K07025	-	ko00000	hydrolase
MKMBIGCO_02262	0.0	yhcX	-	-	K	-	-	-	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
MKMBIGCO_02263	0.0	yhxA	-	-	E	-	-	-	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKMBIGCO_02264	8.57e-134	glpP	-	-	K	ko:K02443	-	ko00000,ko03000	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MKMBIGCO_02265	2.32e-198	glpF	-	-	G	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
MKMBIGCO_02266	0.0	glpK	2.7.1.30	-	C	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MKMBIGCO_02267	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MKMBIGCO_02268	0.0	pgcA	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase
MKMBIGCO_02269	1.45e-87	yhcY	2.7.13.3	-	T	ko:K02480	-	ko00000,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_02270	9.04e-48	yhcZ	-	-	K	ko:K02479	-	ko00000,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_02271	4.84e-116	yhdA	1.7.1.6	-	S	ko:K03206	-	ko00000,ko01000	NADPH-dependent FMN reductase
MKMBIGCO_02272	6.98e-53	yhdB	-	-	S	-	-	-	YhdB-like protein
MKMBIGCO_02273	1.46e-71	yhdC	-	-	S	-	-	-	Protein of unknown function (DUF3889)
MKMBIGCO_02274	3.32e-294	lytF	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MKMBIGCO_02275	7.66e-96	nsrR	-	-	K	ko:K13771	ko05132,map05132	ko00000,ko00001,ko03000	Transcriptional regulator
MKMBIGCO_02276	0.0	ygxB	-	-	M	-	-	-	Conserved TM helix
MKMBIGCO_02277	0.0	spoVR	-	-	S	ko:K06415	-	ko00000	Stage V sporulation protein R
MKMBIGCO_02278	0.0	phoB	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Belongs to the alkaline phosphatase family
MKMBIGCO_02279	3.98e-171	lytE	-	CBM50	M	ko:K19220,ko:K19223,ko:K19224	-	ko00000,ko01000,ko01002,ko01011	COG1388 FOG LysM repeat
MKMBIGCO_02280	1.16e-208	citR	-	-	K	ko:K19242	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02281	6.67e-261	citA	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MKMBIGCO_02282	2.15e-203	yhdF	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_02283	1.78e-316	yhdG	-	-	E	ko:K03294	-	ko00000	amino acid
MKMBIGCO_02284	2.8e-265	yhdH	-	-	S	ko:K03308	-	ko00000	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
MKMBIGCO_02285	8.62e-59	yhdK	-	-	S	-	-	-	Sigma-M inhibitor protein
MKMBIGCO_02286	1.69e-257	yhdL	-	-	S	-	-	-	Sigma factor regulator N-terminal
MKMBIGCO_02287	4.6e-113	sigM	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_02288	8.84e-140	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
MKMBIGCO_02289	3.94e-307	yhdP	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MKMBIGCO_02290	1.97e-92	cueR	-	-	K	ko:K11923	-	ko00000,ko03000	transcriptional
MKMBIGCO_02291	2.01e-286	yhdR	2.6.1.1	-	E	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
MKMBIGCO_02292	4.51e-300	-	2.3.1.179	-	I	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MKMBIGCO_02293	0.0	yhdT	-	-	P	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MKMBIGCO_02294	2.48e-71	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKMBIGCO_02295	4.54e-72	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKMBIGCO_02296	2.89e-162	yhdW	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
MKMBIGCO_02297	1.45e-08	yhdX	-	-	S	-	-	-	Uncharacterized protein YhdX
MKMBIGCO_02298	1.91e-261	yhdY	-	-	M	ko:K16052	-	ko00000,ko02000	Mechanosensitive ion channel
MKMBIGCO_02299	1.19e-179	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form
MKMBIGCO_02300	4.69e-199	nodB1	-	-	G	-	-	-	deacetylase
MKMBIGCO_02301	5.67e-196	dat	2.6.1.21	-	E	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	ko00000,ko00001,ko01000,ko01007	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
MKMBIGCO_02302	1e-113	pksA	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_02303	8.96e-123	ymcC	-	-	S	-	-	-	Membrane
MKMBIGCO_02304	7.15e-110	-	-	-	T	-	-	-	universal stress protein
MKMBIGCO_02306	0.0	yheI	-	-	V	ko:K18216,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MKMBIGCO_02307	0.0	yheH	-	-	V	ko:K18217,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko01504,ko02000	COG1132 ABC-type multidrug transport system, ATPase and permease components
MKMBIGCO_02308	1.11e-141	yheG	-	-	GM	-	-	-	NAD(P)H-binding
MKMBIGCO_02310	3.3e-39	sspB	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
MKMBIGCO_02311	2.12e-49	yheE	-	-	S	-	-	-	Family of unknown function (DUF5342)
MKMBIGCO_02312	0.0	yheD	-	-	HJ	-	-	-	YheC/D like ATP-grasp
MKMBIGCO_02313	4.41e-272	yheC	-	-	HJ	-	-	-	YheC/D like ATP-grasp
MKMBIGCO_02314	3.19e-263	yheB	-	-	S	-	-	-	Belongs to the UPF0754 family
MKMBIGCO_02315	3.3e-70	yheA	-	-	S	-	-	-	Belongs to the UPF0342 family
MKMBIGCO_02316	9.66e-256	yhaZ	-	-	L	-	-	-	DNA alkylation repair enzyme
MKMBIGCO_02317	9.87e-204	yhaX	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
MKMBIGCO_02318	0.0	hemZ	-	-	H	-	-	-	coproporphyrinogen III oxidase
MKMBIGCO_02319	2.89e-316	-	1.14.13.59	-	Q	ko:K03897	ko00310,ko01120,map00310,map01120	ko00000,ko00001,ko01000	L-lysine 6-monooxygenase (NADPH-requiring)
MKMBIGCO_02320	8.13e-266	yhaU	-	-	P	ko:K03455	-	ko00000	COG0475 Kef-type K transport systems, membrane components
MKMBIGCO_02321	8.88e-112	-	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
MKMBIGCO_02323	4.11e-175	yhaR	-	-	I	-	-	-	enoyl-CoA hydratase
MKMBIGCO_02324	7.01e-20	-	-	-	S	-	-	-	YhzD-like protein
MKMBIGCO_02325	5.34e-213	yhaQ	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_02326	2.05e-278	yhaP	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	COG1668 ABC-type Na efflux pump, permease component
MKMBIGCO_02327	8.71e-299	yhaO	-	-	L	ko:K03547	-	ko00000,ko03400	DNA repair exonuclease
MKMBIGCO_02328	0.0	yhaN	-	-	L	-	-	-	AAA domain
MKMBIGCO_02329	2.48e-226	yhaM	-	-	L	ko:K03698	-	ko00000,ko01000,ko03019	Shows a 3'-5' exoribonuclease activity
MKMBIGCO_02330	5.79e-43	yhaL	-	-	S	-	-	-	Sporulation protein YhaL
MKMBIGCO_02331	1.53e-184	prsA	5.2.1.8	-	M	ko:K01802,ko:K07533	-	ko00000,ko01000,ko03110	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
MKMBIGCO_02332	1.29e-123	yhaK	-	-	S	-	-	-	Putative zincin peptidase
MKMBIGCO_02333	1.2e-72	yhaI	-	-	S	-	-	-	Protein of unknown function (DUF1878)
MKMBIGCO_02334	8.17e-147	hpr	-	-	K	ko:K09682	-	ko00000,ko03000	Negative regulator of protease production and sporulation
MKMBIGCO_02335	4.74e-55	yhaH	-	-	S	-	-	-	YtxH-like protein
MKMBIGCO_02336	2.55e-24	-	-	-	-	-	-	-	-
MKMBIGCO_02337	8.25e-100	trpP	-	-	S	-	-	-	Tryptophan transporter TrpP
MKMBIGCO_02338	1.69e-258	serC	2.6.1.52	-	E	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MKMBIGCO_02339	8.27e-105	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
MKMBIGCO_02340	7.42e-174	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	transporter (ATP-binding protein)
MKMBIGCO_02341	9.11e-281	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
MKMBIGCO_02342	3.38e-159	ecsC	-	-	S	-	-	-	EcsC protein family
MKMBIGCO_02343	9.88e-283	yhaA	-	-	E	ko:K01436	-	ko00000,ko01000,ko01002	COG1473 Metal-dependent amidase aminoacylase carboxypeptidase
MKMBIGCO_02344	1.39e-311	yhfA	-	-	C	-	-	-	membrane
MKMBIGCO_02345	3.1e-117	traP	1.14.99.57	-	S	ko:K21481	-	ko00000,ko01000	enzyme involved in biosynthesis of extracellular polysaccharides
MKMBIGCO_02346	0.0	pbpF	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
MKMBIGCO_02347	2.99e-258	hemE	4.1.1.37	-	H	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MKMBIGCO_02348	1.29e-231	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
MKMBIGCO_02349	0.0	hemY	1.3.3.15, 1.3.3.4	-	H	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MKMBIGCO_02350	3.1e-131	yhgD	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02351	0.0	yhgE	-	-	S	ko:K01421	-	ko00000	YhgE Pip N-terminal domain protein
MKMBIGCO_02352	2.41e-234	fabHB	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKMBIGCO_02354	8.97e-252	yhfE	-	-	G	-	-	-	peptidase M42
MKMBIGCO_02355	3.43e-282	gltT	-	-	C	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	ko00000,ko00001,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MKMBIGCO_02357	8.09e-181	yhfI	-	-	S	-	-	-	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
MKMBIGCO_02358	1.85e-241	lplJ	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
MKMBIGCO_02359	5.81e-139	yhfK	-	-	GM	-	-	-	NmrA-like family
MKMBIGCO_02360	0.0	yhfL	6.2.1.3	-	IQ	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
MKMBIGCO_02361	7.96e-85	yhfM	-	-	-	-	-	-	-
MKMBIGCO_02362	1.24e-298	yhfN	-	-	O	-	-	-	Peptidase M48
MKMBIGCO_02363	1.84e-260	aprE	3.4.21.62	-	O	ko:K01342,ko:K13277	ko02024,map02024	ko00000,ko00001,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
MKMBIGCO_02364	4.24e-191	-	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4594 ABC-type Fe3 -citrate transport system, periplasmic component
MKMBIGCO_02365	1.73e-133	yhfR	5.4.2.12	-	G	ko:K15634,ko:K15640	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the phosphoglycerate mutase family
MKMBIGCO_02366	5.84e-252	yhfS	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
MKMBIGCO_02367	0.0	vraA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	AMP-binding enzyme C-terminal domain
MKMBIGCO_02368	7.56e-116	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
MKMBIGCO_02369	3.24e-276	hemAT	-	-	NT	ko:K06595	-	ko00000,ko02035	chemotaxis protein
MKMBIGCO_02370	0.0	yhfW	-	-	CE	-	-	-	COG0665 Glycine D-amino acid oxidases (deaminating)
MKMBIGCO_02371	1.35e-204	yhxC	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_02372	3.87e-42	yhzC	-	-	S	-	-	-	IDEAL
MKMBIGCO_02373	1.09e-141	comK	-	-	K	ko:K02250	ko02024,map02024	ko00000,ko00001,ko02044,ko03000	Competence transcription factor
MKMBIGCO_02374	9.09e-67	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
MKMBIGCO_02375	9.96e-82	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
MKMBIGCO_02376	1.49e-161	yrpD	-	-	S	-	-	-	Domain of unknown function, YrpD
MKMBIGCO_02377	1.23e-57	yhjA	-	-	S	-	-	-	Excalibur calcium-binding domain
MKMBIGCO_02378	7.56e-63	-	-	-	S	-	-	-	Belongs to the UPF0145 family
MKMBIGCO_02379	0.0	yhjB	-	-	E	ko:K03307	-	ko00000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKMBIGCO_02380	5.59e-37	yhjC	-	-	S	-	-	-	Protein of unknown function (DUF3311)
MKMBIGCO_02381	4.12e-79	yhjD	-	-	-	-	-	-	-
MKMBIGCO_02382	5.48e-143	yhjE	-	-	S	-	-	-	SNARE associated Golgi protein
MKMBIGCO_02383	3.32e-119	spsB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
MKMBIGCO_02384	0.0	yhjG	-	-	CH	-	-	-	FAD binding domain
MKMBIGCO_02385	5.71e-121	yhjH	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_02386	1.99e-261	yhjN	-	-	S	ko:K07120	-	ko00000	membrane
MKMBIGCO_02387	1.78e-266	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_02388	3.71e-140	-	-	-	K	-	-	-	QacR-like protein, C-terminal region
MKMBIGCO_02389	3.6e-122	yhjR	-	-	S	-	-	-	Rubrerythrin
MKMBIGCO_02390	1.07e-152	ydfS	-	-	S	-	-	-	Protein of unknown function (DUF421)
MKMBIGCO_02391	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	ATP-dependent helicase deoxyribonuclease subunit B
MKMBIGCO_02392	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
MKMBIGCO_02393	3.31e-283	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
MKMBIGCO_02394	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	COG0419 ATPase involved in DNA repair
MKMBIGCO_02395	7.58e-67	yisB	-	-	V	-	-	-	COG1403 Restriction endonuclease
MKMBIGCO_02396	6.66e-43	gerPF	-	-	S	ko:K06299,ko:K06304	-	ko00000	Spore germination protein gerPA/gerPF
MKMBIGCO_02397	1.61e-84	gerPE	-	-	S	ko:K06303	-	ko00000	Spore germination protein GerPE
MKMBIGCO_02398	3e-33	gerPD	-	-	S	ko:K06302	-	ko00000	Spore germination protein
MKMBIGCO_02399	8.51e-109	gerPC	-	-	S	ko:K06301	-	ko00000	Spore germination protein
MKMBIGCO_02400	3.82e-47	gerPB	-	-	S	ko:K06300	-	ko00000	cell differentiation
MKMBIGCO_02401	1.28e-45	gerPA	-	-	S	ko:K06299	-	ko00000	Spore germination protein
MKMBIGCO_02402	1.03e-11	yisI	-	-	S	-	-	-	Spo0E like sporulation regulatory protein
MKMBIGCO_02403	1.04e-216	yisK	-	-	Q	-	-	-	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
MKMBIGCO_02404	6.36e-78	yisL	-	-	S	-	-	-	UPF0344 protein
MKMBIGCO_02405	1.07e-123	yisN	-	-	S	-	-	-	Protein of unknown function (DUF2777)
MKMBIGCO_02406	0.0	asnO	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
MKMBIGCO_02407	7.37e-169	crtM	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	phytoene
MKMBIGCO_02408	2.14e-312	yisQ	-	-	V	-	-	-	Mate efflux family protein
MKMBIGCO_02409	1.35e-205	yisR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_02410	2.46e-182	rbsR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	helix_turn _helix lactose operon repressor
MKMBIGCO_02411	9.41e-195	yisS	1.1.1.18, 1.1.1.369, 1.1.1.370	-	S	ko:K00010,ko:K16043	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	ko00000,ko00001,ko01000	Oxidoreductase family, C-terminal alpha/beta domain
MKMBIGCO_02412	1.08e-107	yisT	-	-	S	-	-	-	DinB family
MKMBIGCO_02413	2.62e-109	yisX	-	-	S	-	-	-	Pentapeptide repeats (9 copies)
MKMBIGCO_02414	5.16e-104	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_02415	0.0	yitJ	1.5.1.20, 2.1.1.10	-	E	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine
MKMBIGCO_02416	3.69e-78	yitK	-	-	S	ko:K09767	-	ko00000	Belongs to the UPF0234 family
MKMBIGCO_02417	4.36e-204	yitL	-	-	S	ko:K00243	-	ko00000	protein conserved in bacteria
MKMBIGCO_02418	4.04e-217	-	-	-	S	ko:K07335	-	ko00000	ABC transporter substrate-binding protein PnrA-like
MKMBIGCO_02419	2.77e-137	yvaQ	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
MKMBIGCO_02421	5.06e-199	yitS	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02422	6.56e-189	yitT	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_02423	8.76e-104	ipi	-	-	S	-	-	-	Intracellular proteinase inhibitor
MKMBIGCO_02424	1.5e-36	-	-	-	S	-	-	-	Protein of unknown function (DUF3813)
MKMBIGCO_02425	1.49e-11	-	-	-	-	-	-	-	-
MKMBIGCO_02426	2.42e-195	-	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
MKMBIGCO_02427	1.06e-186	yitV	-	-	S	ko:K06889	-	ko00000	COG1073 Hydrolases of the alpha beta superfamily
MKMBIGCO_02428	3.26e-68	yitW	-	-	S	-	-	-	metal-sulfur cluster biosynthetic enzyme
MKMBIGCO_02429	1.7e-94	fosB	-	-	H	ko:K11210,ko:K21252	-	ko00000,ko01000,ko01504	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
MKMBIGCO_02430	0.0	yitY	-	-	C	-	-	-	D-arabinono-1,4-lactone oxidase
MKMBIGCO_02431	1.18e-121	yitZ	-	-	G	-	-	-	Major Facilitator Superfamily
MKMBIGCO_02432	1.23e-253	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MKMBIGCO_02433	2.99e-289	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MKMBIGCO_02434	5.17e-175	argB	2.7.2.8	-	F	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKMBIGCO_02435	3.81e-275	argD	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	acetylornithine aminotransferase
MKMBIGCO_02436	1.34e-256	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
MKMBIGCO_02437	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase ammonia chain
MKMBIGCO_02438	1.13e-222	argF	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MKMBIGCO_02439	7.21e-39	yjzC	-	-	S	-	-	-	YjzC-like protein
MKMBIGCO_02440	1.06e-32	yjzD	-	-	S	-	-	-	Protein of unknown function (DUF2929)
MKMBIGCO_02441	5.47e-179	yjaU	-	-	I	-	-	-	carboxylic ester hydrolase activity
MKMBIGCO_02442	1.32e-131	yjaV	-	-	-	-	-	-	-
MKMBIGCO_02443	2.22e-211	med	-	-	S	ko:K05519,ko:K07335	-	ko00000,ko03000	Transcriptional activator protein med
MKMBIGCO_02444	6.46e-37	comZ	-	-	S	ko:K02254	-	ko00000,ko02044	ComZ
MKMBIGCO_02445	8.09e-44	yjzB	-	-	-	-	-	-	-
MKMBIGCO_02446	7.63e-220	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKMBIGCO_02447	3.86e-300	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
MKMBIGCO_02448	1.84e-190	yjaZ	-	-	O	-	-	-	Zn-dependent protease
MKMBIGCO_02449	6.88e-231	appD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02450	1.03e-237	appF	-	-	E	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02451	0.0	appA	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0747 ABC-type dipeptide transport system, periplasmic component
MKMBIGCO_02452	1.16e-216	appB	-	-	P	ko:K02033	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_02453	9.66e-198	appC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_02454	1.52e-188	yjbA	-	-	S	-	-	-	Belongs to the UPF0736 family
MKMBIGCO_02455	1.45e-233	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Tryptophanyl-tRNA synthetase
MKMBIGCO_02456	0.0	oppA	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MKMBIGCO_02457	2.53e-213	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_02458	5.09e-210	oppC	-	-	EP	ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKMBIGCO_02459	1.5e-256	oppD	-	-	P	ko:K02031,ko:K15583,ko:K16202	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02460	1.22e-217	oppF	-	-	E	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02461	2.88e-294	-	-	-	S	-	-	-	Putative glycosyl hydrolase domain
MKMBIGCO_02462	7.3e-131	yjbC	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MKMBIGCO_02463	2.47e-88	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
MKMBIGCO_02464	5.59e-141	yjbE	-	-	P	-	-	-	Integral membrane protein TerC family
MKMBIGCO_02465	9.78e-150	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC
MKMBIGCO_02466	2.49e-276	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
MKMBIGCO_02467	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
MKMBIGCO_02468	3.14e-27	-	-	-	-	-	-	-	-
MKMBIGCO_02469	6.05e-220	yjbH	-	-	Q	-	-	-	dithiol-disulfide isomerase involved in polyketide biosynthesis
MKMBIGCO_02470	1.22e-93	yjbI	-	-	S	ko:K06886	-	ko00000	Bacterial-like globin
MKMBIGCO_02471	2.99e-150	yjbJ	-	-	M	-	-	-	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
MKMBIGCO_02472	3.9e-123	yjbK	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02473	6.79e-79	yjbL	-	-	S	-	-	-	Belongs to the UPF0738 family
MKMBIGCO_02474	9.01e-139	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	GTP pyrophosphokinase
MKMBIGCO_02475	2.07e-194	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKMBIGCO_02476	1.42e-212	rluD	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
MKMBIGCO_02477	5.06e-182	prpE	3.1.3.16, 3.6.1.41	-	T	ko:K01090,ko:K01525	ko00230,map00230	ko00000,ko00001,ko01000	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP
MKMBIGCO_02478	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
MKMBIGCO_02479	2.71e-175	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MKMBIGCO_02480	4.68e-138	tenI	5.3.99.10	-	H	ko:K10810	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Transcriptional regulator TenI
MKMBIGCO_02481	3.75e-267	thiO	1.4.3.19, 1.4.5.1	-	E	ko:K00285,ko:K03153	ko00360,ko00730,ko01100,map00360,map00730,map01100	ko00000,ko00001,ko01000	Glycine oxidase
MKMBIGCO_02482	4.53e-41	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	Thiamine biosynthesis
MKMBIGCO_02483	7.36e-173	thiG	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
MKMBIGCO_02484	2.07e-236	thiF	2.7.7.73, 2.7.7.80	-	H	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
MKMBIGCO_02485	3.03e-189	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
MKMBIGCO_02486	6.85e-180	fabI	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl- acyl-carrier-protein reductase NADH
MKMBIGCO_02487	6.53e-123	yjbX	-	-	S	-	-	-	Spore coat protein
MKMBIGCO_02488	2.1e-108	cotZ	-	-	S	ko:K06344	-	ko00000	Spore coat protein
MKMBIGCO_02489	4.28e-121	cotY	-	-	S	ko:K06343	-	ko00000	Spore coat protein Z
MKMBIGCO_02490	2.61e-100	cotX	-	-	S	ko:K06342	-	ko00000	Spore Coat Protein X and V domain
MKMBIGCO_02491	8.38e-36	cotW	-	-	-	ko:K06341	-	ko00000	-
MKMBIGCO_02492	2.67e-68	cotV	-	-	S	ko:K06340	-	ko00000	Spore Coat Protein X and V domain
MKMBIGCO_02493	2.05e-73	yjcA	-	-	S	-	-	-	Protein of unknown function (DUF1360)
MKMBIGCO_02497	2.57e-51	spoVIF	-	-	S	-	-	-	Stage VI sporulation protein F
MKMBIGCO_02498	0.0	yjcD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MKMBIGCO_02499	5e-48	-	-	-	-	-	-	-	-
MKMBIGCO_02500	3.99e-179	blm	3.5.2.6	-	S	ko:K17837	ko01501,map01501	ko00000,ko00001,ko01000	Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family
MKMBIGCO_02501	5.35e-159	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MKMBIGCO_02502	4.81e-169	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
MKMBIGCO_02503	1.76e-47	-	-	-	K	-	-	-	SpoVT / AbrB like domain
MKMBIGCO_02505	1.18e-94	yjcF	-	-	S	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MKMBIGCO_02506	2.43e-121	yjcG	-	-	J	-	-	-	Belongs to the 2H phosphoesterase superfamily. YjcG family
MKMBIGCO_02507	1.43e-163	yjcH	-	-	P	ko:K07214	-	ko00000	COG2382 Enterochelin esterase and related enzymes
MKMBIGCO_02508	8.87e-268	metB	2.5.1.48	-	E	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MKMBIGCO_02509	1.15e-279	metC	4.4.1.8	-	E	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MKMBIGCO_02511	2.2e-39	-	-	-	-	-	-	-	-
MKMBIGCO_02512	7.58e-107	-	-	-	-	-	-	-	-
MKMBIGCO_02513	6.63e-224	-	-	-	S	-	-	-	Bacterial EndoU nuclease
MKMBIGCO_02514	5.61e-121	-	-	-	-	-	-	-	-
MKMBIGCO_02516	8.05e-166	-	-	-	-	-	-	-	-
MKMBIGCO_02517	4.36e-05	ywlA	-	-	S	-	-	-	Uncharacterised protein family (UPF0715)
MKMBIGCO_02521	3.14e-76	-	-	-	E	-	-	-	Glyoxalase-like domain
MKMBIGCO_02522	1.11e-208	penP	3.5.2.6	-	V	ko:K17836,ko:K18766	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	beta-lactamase
MKMBIGCO_02523	1.81e-60	yjcS	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
MKMBIGCO_02524	0.0	yfjF	-	-	EGP	-	-	-	Belongs to the major facilitator superfamily
MKMBIGCO_02525	4.3e-106	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_02526	4.29e-278	yvfO	3.2.1.89	-	G	ko:K01224	-	ko00000,ko01000	arabinogalactan
MKMBIGCO_02527	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
MKMBIGCO_02528	2.34e-239	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKMBIGCO_02529	2.58e-275	galK	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MKMBIGCO_02530	0.0	lacE	2.7.1.207	-	G	ko:K02761,ko:K02787,ko:K02788	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
MKMBIGCO_02531	5.16e-66	celC	2.7.1.196, 2.7.1.205, 2.7.1.207	-	G	ko:K02759,ko:K02786	ko00052,ko00500,ko01100,ko02060,map00052,map00500,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_02532	0.0	lacG	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MKMBIGCO_02533	1.19e-178	yulB	-	-	K	ko:K02530	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MKMBIGCO_02534	1.1e-156	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
MKMBIGCO_02535	2.03e-190	-	-	-	N	-	-	-	Kelch motif
MKMBIGCO_02537	2.48e-136	-	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC SapB transporter
MKMBIGCO_02539	3.85e-31	yjfB	-	-	S	-	-	-	Putative motility protein
MKMBIGCO_02540	2.76e-86	yjgA	-	-	T	-	-	-	Protein of unknown function (DUF2809)
MKMBIGCO_02541	1.94e-129	yjgB	-	-	S	-	-	-	Domain of unknown function (DUF4309)
MKMBIGCO_02542	0.0	-	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase, alpha subunit
MKMBIGCO_02543	2.2e-117	yjgD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MKMBIGCO_02544	2.45e-286	yjiB	1.14.14.46	-	C	ko:K15468,ko:K16593	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	Cytochrome P450
MKMBIGCO_02545	1.83e-280	yjiC	-	-	CG	-	-	-	COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
MKMBIGCO_02546	1.73e-40	-	-	-	-	-	-	-	-
MKMBIGCO_02547	2.65e-183	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
MKMBIGCO_02548	1.45e-158	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	transport system, permease component
MKMBIGCO_02549	8.84e-166	yjkB	-	-	P	ko:K02068	-	ko00000,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_02550	1.38e-225	yjlA	-	-	EG	-	-	-	Putative multidrug resistance efflux transporter
MKMBIGCO_02551	1.12e-114	yjlB	-	-	S	-	-	-	Cupin domain
MKMBIGCO_02552	1.7e-87	yjlC	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MKMBIGCO_02553	1.76e-279	yjlD	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MKMBIGCO_02554	0.0	uxaC	5.3.1.12	-	G	ko:K01812	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	glucuronate isomerase
MKMBIGCO_02555	0.0	-	-	-	G	ko:K03292	-	ko00000	symporter YjmB
MKMBIGCO_02556	9.79e-233	exuR	-	-	K	ko:K02529	-	ko00000,ko03000	transcriptional
MKMBIGCO_02557	0.0	uxaB	1.1.1.58	-	G	ko:K00041	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	tagaturonate reductase activity
MKMBIGCO_02558	0.0	uxaA	4.2.1.7	-	G	ko:K01685	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000	Altronate
MKMBIGCO_02559	2.6e-112	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
MKMBIGCO_02560	1.05e-168	-	-	-	T	-	-	-	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
MKMBIGCO_02561	6.68e-20	-	-	-	V	ko:K01990,ko:K20459	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_02563	7.56e-166	yjnA	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MKMBIGCO_02564	1.19e-102	yjoA	-	-	S	-	-	-	DinB family
MKMBIGCO_02565	1.55e-274	rapA	-	-	S	ko:K06359,ko:K06360,ko:K06367	ko02024,map02024	ko00000,ko00001,ko01000	Response regulator aspartate phosphatase
MKMBIGCO_02567	1.84e-213	xlyB	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
MKMBIGCO_02568	2.73e-80	yjqA	-	-	S	-	-	-	Bacterial PH domain
MKMBIGCO_02569	7.55e-142	yjqB	-	-	S	-	-	-	phage-related replication protein
MKMBIGCO_02571	7.61e-144	xkdA	-	-	E	-	-	-	IrrE N-terminal-like domain
MKMBIGCO_02572	6.52e-75	xre	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MKMBIGCO_02574	1.15e-191	xkdC	-	-	L	-	-	-	Bacterial dnaA protein
MKMBIGCO_02578	1.02e-108	xpf	-	-	K	ko:K03088	-	ko00000,ko03021	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
MKMBIGCO_02579	2.9e-141	xtmA	-	-	L	ko:K07474	-	ko00000	phage terminase small subunit
MKMBIGCO_02580	8.55e-264	xtmB	-	-	S	ko:K06909	-	ko00000	phage terminase, large subunit
MKMBIGCO_02581	7.29e-303	xkdE3	-	-	S	-	-	-	portal protein
MKMBIGCO_02582	5.26e-118	xkdF3	-	-	L	-	-	-	Putative phage serine protease XkdF
MKMBIGCO_02583	2.9e-203	xkdG	-	-	S	-	-	-	Phage capsid family
MKMBIGCO_02584	2.53e-60	yqbG	-	-	S	-	-	-	Protein of unknown function (DUF3199)
MKMBIGCO_02585	1.17e-55	-	-	-	S	-	-	-	Domain of unknown function (DUF3599)
MKMBIGCO_02586	4.86e-77	xkdI	-	-	S	-	-	-	Bacteriophage HK97-gp10, putative tail-component
MKMBIGCO_02587	4.99e-73	xkdJ	-	-	-	-	-	-	-
MKMBIGCO_02588	3.86e-21	-	-	-	-	-	-	-	-
MKMBIGCO_02589	3.28e-287	xkdK	-	-	S	-	-	-	Phage tail sheath C-terminal domain
MKMBIGCO_02590	8.21e-97	xkdM	-	-	S	-	-	-	Phage tail tube protein
MKMBIGCO_02591	7.28e-96	-	-	-	S	-	-	-	Phage XkdN-like tail assembly chaperone protein, TAC
MKMBIGCO_02592	4.33e-27	-	-	-	-	-	-	-	-
MKMBIGCO_02595	0.0	ilvB	2.2.1.6	-	E	ko:K01652,ko:K16787	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
MKMBIGCO_02596	2.06e-109	ilvN	2.2.1.6	-	E	ko:K01653,ko:K16785	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Acetolactate synthase
MKMBIGCO_02597	2.75e-244	ilvC	1.1.1.86	-	EH	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MKMBIGCO_02598	0.0	leuA	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKMBIGCO_02599	1.23e-254	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
MKMBIGCO_02600	0.0	leuC	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MKMBIGCO_02601	3.1e-149	leuD	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MKMBIGCO_02602	2.25e-239	ysoA	-	-	H	-	-	-	Tetratricopeptide repeat
MKMBIGCO_02603	2.18e-287	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
MKMBIGCO_02604	3.83e-295	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MKMBIGCO_02605	0.0	lonB	3.4.21.53	-	LO	ko:K04076	-	ko00000,ko01000,ko01002	Belongs to the peptidase S16 family
MKMBIGCO_02606	0.0	lon	3.4.21.53	-	O	ko:K01338	ko04112,map04112	ko00000,ko00001,ko01000,ko01002	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MKMBIGCO_02607	3.1e-138	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
MKMBIGCO_02608	3.93e-114	ysxD	-	-	-	-	-	-	-
MKMBIGCO_02609	1.24e-314	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MKMBIGCO_02610	2.19e-185	hemX	-	-	O	ko:K02497	-	ko00000	cytochrome C
MKMBIGCO_02611	1.05e-222	hemC	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
MKMBIGCO_02612	6.6e-181	hemD	4.2.1.75	-	H	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase
MKMBIGCO_02613	1.02e-235	hemB	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the ALAD family
MKMBIGCO_02614	4.63e-312	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Glutamate-1-semialdehyde aminotransferase
MKMBIGCO_02615	1.36e-299	spoVID	-	-	M	ko:K06417	-	ko00000	stage VI sporulation protein D
MKMBIGCO_02616	6.33e-250	ysxE	-	-	S	-	-	-	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MKMBIGCO_02617	1.53e-35	-	-	-	-	-	-	-	-
MKMBIGCO_02618	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
MKMBIGCO_02619	2.09e-304	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
MKMBIGCO_02620	4.26e-170	comC	3.4.23.43	-	NOU	ko:K02236,ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
MKMBIGCO_02621	4.22e-207	spoIIB	-	-	S	ko:K06380	-	ko00000	Sporulation related domain
MKMBIGCO_02622	5.35e-127	maf	-	-	D	ko:K06287	-	ko00000	septum formation protein Maf
MKMBIGCO_02623	7.15e-164	radC	-	-	E	ko:K03630	-	ko00000	Belongs to the UPF0758 family
MKMBIGCO_02624	1.06e-234	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Rod shape-determining protein MreB
MKMBIGCO_02625	2.51e-201	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
MKMBIGCO_02626	1.76e-110	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	shape-determining protein
MKMBIGCO_02627	6.85e-155	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
MKMBIGCO_02628	1.61e-183	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
MKMBIGCO_02629	1.39e-188	spoIVFA	-	-	M	ko:K06401	-	ko00000	COG0739 Membrane proteins related to metalloendopeptidases
MKMBIGCO_02630	5.1e-206	spoIVFB	-	-	S	ko:K06402	-	ko00000,ko01000,ko01002	Stage IV sporulation protein
MKMBIGCO_02631	1.28e-65	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
MKMBIGCO_02632	1.42e-74	ysxB	-	-	J	ko:K07584	-	ko00000	ribosomal protein
MKMBIGCO_02633	7.74e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
MKMBIGCO_02634	3.5e-138	spo0B	-	-	T	ko:K06375	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko01000	Sporulation initiation phospho-transferase B, C-terminal
MKMBIGCO_02635	2.37e-309	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MKMBIGCO_02636	5.94e-95	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
MKMBIGCO_02637	8.16e-206	pheA	4.2.1.51	-	E	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydratase
MKMBIGCO_02638	1.18e-121	yrxA	-	-	S	ko:K07105	-	ko00000	small molecule binding protein (contains 3H domain)
MKMBIGCO_02639	6.4e-282	nifS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MKMBIGCO_02640	0.0	nadB	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of L-aspartate to iminoaspartate
MKMBIGCO_02641	4.13e-193	nadC	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NadC ModD family
MKMBIGCO_02642	2.02e-270	nadA	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MKMBIGCO_02643	2.57e-248	safA	-	-	M	ko:K06370	-	ko00000	spore coat assembly protein SafA
MKMBIGCO_02644	2.21e-61	-	-	-	S	ko:K06345	-	ko00000	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
MKMBIGCO_02646	1.03e-121	bofC	-	-	S	ko:K06318	-	ko00000	BofC C-terminal domain
MKMBIGCO_02647	8.13e-137	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
MKMBIGCO_02648	3.57e-236	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
MKMBIGCO_02649	2.8e-28	yrzS	-	-	S	-	-	-	Protein of unknown function (DUF2905)
MKMBIGCO_02650	5.79e-246	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MKMBIGCO_02651	8.2e-293	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
MKMBIGCO_02652	1.03e-50	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit YajC
MKMBIGCO_02653	9.08e-81	yrzE	-	-	S	-	-	-	Protein of unknown function (DUF3792)
MKMBIGCO_02654	2.03e-143	yrbG	-	-	S	-	-	-	membrane
MKMBIGCO_02655	0.0	spoVB	-	-	S	ko:K06409	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_02656	4.04e-67	yrzD	-	-	S	-	-	-	Post-transcriptional regulator
MKMBIGCO_02657	0.0	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKMBIGCO_02658	8.88e-112	trkA1	-	-	P	ko:K07228	-	ko00000	regulatory, ligand-binding protein related to C-terminal domains of K channels
MKMBIGCO_02659	7.78e-63	yrvD	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
MKMBIGCO_02660	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
MKMBIGCO_02661	5.1e-118	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKMBIGCO_02662	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKMBIGCO_02663	5.78e-97	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
MKMBIGCO_02664	0.0	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	COG3103 SH3 domain protein
MKMBIGCO_02667	1e-308	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
MKMBIGCO_02668	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MKMBIGCO_02669	1.96e-177	yrvM	-	-	H	ko:K22132	-	ko00000,ko03016	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
MKMBIGCO_02670	3.74e-303	rarA	-	-	L	ko:K07478	-	ko00000	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
MKMBIGCO_02671	9.19e-84	cymR	-	-	K	ko:K17472	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_02672	2.98e-269	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MKMBIGCO_02673	5.04e-282	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
MKMBIGCO_02674	1.12e-23	yrrB	-	-	S	-	-	-	COG0457 FOG TPR repeat
MKMBIGCO_02675	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
MKMBIGCO_02676	1.69e-105	yrrD	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02677	8.4e-42	yrzR	-	-	-	-	-	-	-
MKMBIGCO_02678	6.52e-13	-	-	-	S	-	-	-	Protein of unknown function (DUF3918)
MKMBIGCO_02679	3.1e-138	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MKMBIGCO_02680	3.24e-139	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MKMBIGCO_02681	1.82e-188	glnH	-	-	ET	ko:K09969,ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MKMBIGCO_02682	3.66e-167	glnQ	-	-	E	ko:K09972,ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MKMBIGCO_02683	4.47e-235	yrrI	-	-	S	-	-	-	AI-2E family transporter
MKMBIGCO_02684	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MKMBIGCO_02685	1.29e-54	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
MKMBIGCO_02686	2.72e-93	yrrK	-	-	L	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKMBIGCO_02687	7.2e-61	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
MKMBIGCO_02688	4.48e-256	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKMBIGCO_02689	2.22e-151	yrrM	2.1.1.104	-	S	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	ko00000,ko00001,ko00002,ko01000	O-methyltransferase
MKMBIGCO_02690	6.3e-222	yrrN	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase U32
MKMBIGCO_02691	1.09e-311	yrrO	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	COG0826 Collagenase and related proteases
MKMBIGCO_02692	2.61e-147	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
MKMBIGCO_02693	1.62e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
MKMBIGCO_02694	0.0	pbpI	-	-	M	ko:K21468	-	ko00000,ko01011	Penicillin-binding Protein
MKMBIGCO_02695	3.56e-124	yrrS	-	-	S	-	-	-	Protein of unknown function (DUF1510)
MKMBIGCO_02696	1.78e-38	yrzA	-	-	S	-	-	-	Protein of unknown function (DUF2536)
MKMBIGCO_02697	1.35e-150	yrrT	-	-	Q	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Could be a S-adenosyl-L-methionine-dependent methyltransferase
MKMBIGCO_02698	5.64e-161	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKMBIGCO_02699	1.61e-218	mccA	2.5.1.134, 2.5.1.47	-	E	ko:K01738,ko:K17216	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Cysteine synthase
MKMBIGCO_02700	7.59e-268	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
MKMBIGCO_02701	5.51e-46	yrhC	-	-	S	-	-	-	YrhC-like protein
MKMBIGCO_02702	4.76e-106	yrhD	-	-	S	-	-	-	Protein of unknown function (DUF1641)
MKMBIGCO_02703	0.0	yrhE	1.17.1.9	-	C	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	ko00000,ko00001,ko01000	formate dehydrogenase, alpha subunit
MKMBIGCO_02704	1.48e-78	yrhF	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2294)
MKMBIGCO_02705	3.96e-183	yrhG	-	-	P	ko:K21993	-	ko00000,ko02000	Formate nitrite
MKMBIGCO_02706	2.37e-07	-	-	-	S	-	-	-	Probable sporulation protein (Bac_small_yrzI)
MKMBIGCO_02707	2.12e-119	yrhH	-	-	Q	-	-	-	methyltransferase
MKMBIGCO_02708	4.77e-130	-	-	-	K	ko:K22106	-	ko00000,ko03000	Tetracycline repressor, C-terminal all-alpha domain
MKMBIGCO_02709	0.0	yrhJ	1.14.14.1, 1.6.2.4	-	C	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	ko00000,ko00001,ko00199,ko01000	Belongs to the cytochrome P450 family
MKMBIGCO_02710	2.18e-269	yybF1	-	-	EGP	ko:K08224	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_02711	5.33e-211	yybE	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_02712	5.18e-104	ebsC	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKMBIGCO_02713	1.36e-228	romA	-	-	S	-	-	-	Beta-lactamase superfamily domain
MKMBIGCO_02714	0.0	manR	-	-	GKT	ko:K02538,ko:K03491	-	ko00000,ko03000	transcriptional antiterminator
MKMBIGCO_02715	0.0	manP	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_02716	7.78e-235	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
MKMBIGCO_02717	1.18e-167	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
MKMBIGCO_02718	2.29e-184	supH	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
MKMBIGCO_02719	3.82e-186	supH	-	-	S	-	-	-	hydrolase
MKMBIGCO_02720	1.37e-120	-	-	-	S	-	-	-	DinB family
MKMBIGCO_02721	1.01e-103	-	-	-	K	ko:K19273	-	ko00000,ko01000,ko01504	Acetyltransferase (GNAT) domain
MKMBIGCO_02722	2.53e-278	tetL	-	-	EGP	ko:K08168	-	ko00000,ko00002,ko01504,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_02723	8.13e-05	-	-	-	K	-	-	-	acetyltransferase
MKMBIGCO_02724	2.93e-123	yqaC	-	-	F	-	-	-	adenylate kinase activity
MKMBIGCO_02725	1.6e-188	ydeE	-	-	K	ko:K13653	-	ko00000,ko03000	AraC family transcriptional regulator
MKMBIGCO_02726	3.85e-120	-	-	-	K	-	-	-	Transcriptional regulator PadR-like family
MKMBIGCO_02727	2.16e-203	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
MKMBIGCO_02728	6.78e-160	sigK	-	-	K	ko:K03091	-	ko00000,ko03021	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKMBIGCO_02729	3.73e-269	-	-	-	EGP	-	-	-	Transmembrane secretion effector
MKMBIGCO_02730	6.87e-137	yqeD	-	-	S	-	-	-	SNARE associated Golgi protein
MKMBIGCO_02731	2.23e-178	pdaC	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
MKMBIGCO_02732	1.2e-176	yqeF	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
MKMBIGCO_02734	3.19e-122	yqeG	-	-	S	ko:K07015	-	ko00000	hydrolase of the HAD superfamily
MKMBIGCO_02735	4.59e-271	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	In Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
MKMBIGCO_02736	1.7e-200	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MKMBIGCO_02737	1.81e-60	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein containing KH domain, possibly ribosomal protein
MKMBIGCO_02738	6.82e-139	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MKMBIGCO_02739	5.26e-132	yqeK	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
MKMBIGCO_02740	9.39e-80	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
MKMBIGCO_02741	4.86e-178	yqeM	-	-	Q	-	-	-	Methyltransferase
MKMBIGCO_02742	4.85e-192	comER	-	-	E	ko:K02239	-	ko00000,ko00002,ko02044	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKMBIGCO_02743	1.69e-135	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	COG1555 DNA uptake protein and related DNA-binding proteins
MKMBIGCO_02744	3.79e-136	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
MKMBIGCO_02745	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
MKMBIGCO_02746	7.42e-232	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
MKMBIGCO_02747	1.91e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
MKMBIGCO_02748	1.02e-259	gpr	3.4.24.78	-	C	ko:K06012	-	ko00000,ko01000,ko01002	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MKMBIGCO_02749	2.5e-277	spoIIP	-	-	M	ko:K06385	-	ko00000	stage II sporulation protein P
MKMBIGCO_02750	3.5e-70	yqxA	-	-	S	-	-	-	Protein of unknown function (DUF3679)
MKMBIGCO_02751	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
MKMBIGCO_02752	7.65e-272	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
MKMBIGCO_02753	2.73e-240	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
MKMBIGCO_02754	5.18e-110	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MKMBIGCO_02755	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
MKMBIGCO_02756	4.93e-266	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
MKMBIGCO_02757	6.31e-223	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Methylates ribosomal protein L11
MKMBIGCO_02758	1.44e-180	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
MKMBIGCO_02759	0.0	yqeV	2.8.4.5	-	J	ko:K18707	-	ko00000,ko01000,ko03016	ribosomal protein S12 methylthiotransferase
MKMBIGCO_02760	9.26e-200	yqeW	-	-	P	ko:K03324	-	ko00000,ko02000	COG1283 Na phosphate symporter
MKMBIGCO_02761	1.03e-26	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
MKMBIGCO_02762	6.44e-90	yqeY	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
MKMBIGCO_02763	1.34e-295	yqeZ	-	-	O	ko:K07403	-	ko00000	COG1030 Membrane-bound serine protease (ClpP class)
MKMBIGCO_02764	1.3e-174	yqfA	-	-	S	-	-	-	UPF0365 protein
MKMBIGCO_02765	2.85e-82	yqfB	-	-	-	-	-	-	-
MKMBIGCO_02766	3.57e-61	yqfC	-	-	S	-	-	-	sporulation protein YqfC
MKMBIGCO_02767	3.72e-282	yqfD	-	-	S	ko:K06438	-	ko00000	Stage IV sporulation
MKMBIGCO_02768	7.08e-224	phoH	-	-	T	ko:K06217	-	ko00000	Phosphate starvation-inducible protein PhoH
MKMBIGCO_02769	0.0	yqfF	-	-	S	ko:K07037	-	ko00000	membrane-associated HD superfamily hydrolase
MKMBIGCO_02770	1.44e-104	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MKMBIGCO_02771	5.28e-83	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
MKMBIGCO_02772	1.92e-92	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
MKMBIGCO_02773	8.2e-214	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKMBIGCO_02774	6e-24	-	-	-	S	-	-	-	YqzL-like protein
MKMBIGCO_02775	5.05e-185	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
MKMBIGCO_02776	5.19e-223	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
MKMBIGCO_02777	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
MKMBIGCO_02778	5.89e-145	ccpN	-	-	K	-	-	-	CBS domain
MKMBIGCO_02779	5.46e-192	yqfL	2.7.11.33, 2.7.4.28	-	S	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
MKMBIGCO_02780	1.36e-112	yqxD	-	-	S	ko:K09768	-	ko00000	Belongs to the UPF0178 family
MKMBIGCO_02781	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
MKMBIGCO_02782	3.97e-255	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
MKMBIGCO_02783	1.95e-82	cccA	-	-	C	ko:K13300	-	ko00000	COG2010 Cytochrome c, mono- and diheme variants
MKMBIGCO_02784	1.21e-161	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
MKMBIGCO_02785	2.54e-267	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MKMBIGCO_02786	5.01e-226	ispH	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MKMBIGCO_02787	1.95e-87	yqfQ	-	-	S	-	-	-	YqfQ-like protein
MKMBIGCO_02788	1.05e-308	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
MKMBIGCO_02789	7.01e-213	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MKMBIGCO_02790	8.63e-49	yqfT	-	-	S	-	-	-	Protein of unknown function (DUF2624)
MKMBIGCO_02791	6.35e-198	yqfU	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2179)
MKMBIGCO_02792	2.25e-100	zur	-	-	P	ko:K02076	-	ko00000,ko03000	Belongs to the Fur family
MKMBIGCO_02793	5.81e-142	yqfW	-	-	S	ko:K05967	-	ko00000	Belongs to the 5'(3')-deoxyribonucleotidase family
MKMBIGCO_02794	3.34e-80	yqfX	-	-	S	-	-	-	membrane
MKMBIGCO_02795	1.97e-256	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MKMBIGCO_02796	3.05e-63	yqfZ	-	-	M	ko:K06417	-	ko00000	LysM domain
MKMBIGCO_02797	2.44e-164	yqgB	-	-	S	-	-	-	Protein of unknown function (DUF1189)
MKMBIGCO_02798	2.27e-98	yqgC	-	-	S	ko:K09793	-	ko00000	protein conserved in bacteria
MKMBIGCO_02799	1.72e-147	sodA	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	radicals which are normally produced within the cells and which are toxic to biological systems
MKMBIGCO_02800	9.63e-289	yqgE	-	-	EGP	ko:K08222	-	ko00000,ko02000	Major facilitator superfamily
MKMBIGCO_02801	0.0	pbpA	-	-	M	ko:K21465,ko:K21466	ko00550,map00550	ko00000,ko00001,ko01011	penicillin-binding protein
MKMBIGCO_02802	9.5e-208	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
MKMBIGCO_02803	2.48e-203	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
MKMBIGCO_02804	3.26e-196	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease
MKMBIGCO_02805	4.62e-183	pstBA	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MKMBIGCO_02806	2.32e-188	pstB	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
MKMBIGCO_02807	1.02e-98	yqzC	-	-	S	-	-	-	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKMBIGCO_02808	3.42e-68	yqzD	-	-	-	-	-	-	-
MKMBIGCO_02809	6.25e-29	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
MKMBIGCO_02810	6.07e-126	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKMBIGCO_02811	3.79e-11	yqgO	-	-	-	-	-	-	-
MKMBIGCO_02812	7.52e-301	nhaC	-	-	C	ko:K03315	-	ko00000,ko02000	Na H antiporter
MKMBIGCO_02813	1.51e-37	yqgQ	-	-	S	-	-	-	Protein conserved in bacteria
MKMBIGCO_02814	5.03e-229	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
MKMBIGCO_02815	3.14e-278	yqgT	3.4.19.11	-	E	ko:K01308	-	ko00000,ko01000,ko01002	Gamma-D-glutamyl-L-diamino acid endopeptidase
MKMBIGCO_02816	7.05e-252	yqgU	-	-	-	-	-	-	-
MKMBIGCO_02817	2.02e-63	dglA	-	-	S	-	-	-	Thiamine-binding protein
MKMBIGCO_02818	1.07e-28	yqgW	-	-	S	-	-	-	Protein of unknown function (DUF2759)
MKMBIGCO_02819	2.84e-156	yqgX	3.1.2.6	-	S	ko:K01069	ko00620,map00620	ko00000,ko00001,ko01000	COG0491 Zn-dependent hydrolases, including glyoxylases
MKMBIGCO_02820	4.19e-50	yqgY	-	-	S	-	-	-	Protein of unknown function (DUF2626)
MKMBIGCO_02821	1.15e-86	yqgZ	1.20.4.1	-	P	ko:K00537,ko:K16509	-	ko00000,ko01000	Belongs to the ArsC family
MKMBIGCO_02823	1.96e-188	yqhA	-	-	T	ko:K17763	-	ko00000,ko03021	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
MKMBIGCO_02824	7.58e-304	yqhB	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MKMBIGCO_02825	6.43e-239	yqxL	-	-	P	-	-	-	Mg2 transporter protein
MKMBIGCO_02826	3.84e-258	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKMBIGCO_02827	4.65e-233	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	COG1459 Type II secretory pathway, component PulF
MKMBIGCO_02828	4.46e-66	comGC	-	-	U	ko:K02245	-	ko00000,ko00002,ko02044	Required for transformation and DNA binding
MKMBIGCO_02829	5.36e-92	-	-	-	NU	ko:K02246,ko:K08084	-	ko00000,ko00002,ko02044	Tfp pilus assembly protein FimT
MKMBIGCO_02830	2.21e-26	comGE	-	-	-	ko:K02247	-	ko00000,ko00002,ko02044	-
MKMBIGCO_02831	1.82e-84	comGF	-	-	U	ko:K02248	-	ko00000,ko00002,ko02044	Putative Competence protein ComGF
MKMBIGCO_02832	9.51e-81	-	-	-	S	ko:K02249	-	ko00000,ko00002,ko02044	ComG operon protein 7
MKMBIGCO_02833	2e-36	yqzE	-	-	S	-	-	-	YqzE-like protein
MKMBIGCO_02834	1.97e-70	yqzG	-	-	S	-	-	-	Protein of unknown function (DUF3889)
MKMBIGCO_02835	5.44e-155	yqxM	-	-	-	ko:K19433	-	ko00000	-
MKMBIGCO_02836	8.95e-101	sipW	3.4.21.89	-	U	ko:K13280	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase
MKMBIGCO_02837	1.49e-180	tasA_1	-	-	S	ko:K06336	-	ko00000,ko01002	Cell division protein FtsN
MKMBIGCO_02838	2.75e-72	sinR	-	-	K	ko:K19449	-	ko00000,ko03000	transcriptional
MKMBIGCO_02839	2.31e-32	sinI	-	-	S	ko:K06372	-	ko00000	Anti-repressor SinI
MKMBIGCO_02840	1.52e-195	yqhG	-	-	S	-	-	-	Bacterial protein YqhG of unknown function
MKMBIGCO_02841	0.0	yqhH	-	-	L	-	-	-	COG0553 Superfamily II DNA RNA helicases, SNF2 family
MKMBIGCO_02842	9.52e-264	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine
MKMBIGCO_02843	0.0	gcvPA	1.4.4.2	-	E	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKMBIGCO_02844	0.0	gcvPB	1.4.4.2	-	E	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKMBIGCO_02845	3.18e-84	yqhL	-	-	P	-	-	-	COG0607 Rhodanese-related sulfurtransferase
MKMBIGCO_02846	1.3e-203	lipM	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation
MKMBIGCO_02847	5.64e-97	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon
MKMBIGCO_02848	2.85e-209	yqhO	-	-	S	ko:K07001	-	ko00000	esterase of the alpha-beta hydrolase superfamily
MKMBIGCO_02849	1.54e-82	yqhP	-	-	-	-	-	-	-
MKMBIGCO_02850	7.33e-221	yqhQ	-	-	S	-	-	-	Protein of unknown function (DUF1385)
MKMBIGCO_02851	1.82e-116	yqhR	-	-	S	-	-	-	Conserved membrane protein YqhR
MKMBIGCO_02852	6.04e-249	yqhT	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	COG0006 Xaa-Pro aminopeptidase
MKMBIGCO_02853	6.82e-128	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MKMBIGCO_02854	9.89e-50	yqhV	-	-	S	-	-	-	Protein of unknown function (DUF2619)
MKMBIGCO_02855	1.8e-220	spoIIIAA	-	-	S	ko:K06390	-	ko00000	stage III sporulation protein AA
MKMBIGCO_02856	9.44e-110	spoIIIAB	-	-	S	ko:K06391	-	ko00000	Stage III sporulation protein
MKMBIGCO_02857	1.63e-39	spoIIIAC	-	-	S	ko:K06392	-	ko00000	stage III sporulation protein AC
MKMBIGCO_02858	3.72e-55	spoIIIAD	-	-	S	ko:K06393	-	ko00000	Stage III sporulation protein AD
MKMBIGCO_02859	5.23e-261	spoIIIAE	-	-	S	ko:K06394	-	ko00000	stage III sporulation protein AE
MKMBIGCO_02860	1.05e-130	spoIIIAF	-	-	S	ko:K06395	-	ko00000	Stage III sporulation protein AF (Spore_III_AF)
MKMBIGCO_02861	3.34e-148	spoIIIAG	-	-	S	ko:K06396	-	ko00000	stage III sporulation protein AG
MKMBIGCO_02862	2.74e-94	spoIIIAH	-	-	S	ko:K06397	-	ko00000	SpoIIIAH-like protein
MKMBIGCO_02863	1.63e-86	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
MKMBIGCO_02864	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
MKMBIGCO_02865	1.36e-87	yqhY	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02866	2.58e-85	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKMBIGCO_02867	3.05e-200	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MKMBIGCO_02868	8.28e-310	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MKMBIGCO_02869	2.67e-52	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
MKMBIGCO_02870	6.4e-204	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
MKMBIGCO_02871	0.0	dxs	2.2.1.7	-	H	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MKMBIGCO_02872	2.06e-197	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	rRNA methylase
MKMBIGCO_02873	4.38e-102	argR	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
MKMBIGCO_02874	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
MKMBIGCO_02875	1.47e-302	spoIVB	3.4.21.116	-	M	ko:K06399	-	ko00000,ko01000,ko01002	Stage IV sporulation protein B
MKMBIGCO_02876	1.23e-186	spo0A	-	-	KT	ko:K07699	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process
MKMBIGCO_02877	1.13e-271	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKMBIGCO_02880	1.6e-272	yqiG	-	-	C	-	-	-	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
MKMBIGCO_02882	2.32e-145	-	-	-	K	-	-	-	Protein of unknown function (DUF1232)
MKMBIGCO_02883	1.96e-131	-	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MKMBIGCO_02885	1.97e-136	lytC_1	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Cell wall hydrolase autolysin
MKMBIGCO_02886	1.5e-172	yqiK	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
MKMBIGCO_02887	1.08e-269	mmgA	2.3.1.9	-	I	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
MKMBIGCO_02888	2.51e-199	mmgB	1.1.1.157	-	I	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	ko00000,ko00001,ko01000	Dehydrogenase
MKMBIGCO_02889	4.85e-258	mmgC	-	-	I	ko:K18244	-	ko00000,ko01000	acyl-CoA dehydrogenase
MKMBIGCO_02890	2.71e-258	mmgD	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MKMBIGCO_02891	0.0	prpD	4.2.1.79	-	S	ko:K01720	ko00640,map00640	ko00000,ko00001,ko01000	2-methylcitrate dehydratase
MKMBIGCO_02892	1.56e-202	prpB	4.1.3.30, 5.4.2.9	-	G	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MKMBIGCO_02893	6.25e-47	yqzF	-	-	S	-	-	-	Protein of unknown function (DUF2627)
MKMBIGCO_02894	0.0	bkdR	-	-	KT	-	-	-	Transcriptional regulator
MKMBIGCO_02895	2.27e-193	ptb	2.3.1.19	-	C	ko:K00634	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	phosphate butyryltransferase
MKMBIGCO_02896	1.58e-261	ldh	1.4.1.9	-	E	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
MKMBIGCO_02897	2.23e-259	buk	2.7.2.7	-	C	ko:K00929	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	Belongs to the acetokinase family
MKMBIGCO_02898	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
MKMBIGCO_02899	1.86e-220	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
MKMBIGCO_02900	1.7e-235	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
MKMBIGCO_02901	7.13e-276	bkdB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
MKMBIGCO_02902	1.42e-217	bmrU	-	-	I	-	-	-	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
MKMBIGCO_02903	1.68e-99	yqiW	-	-	S	-	-	-	Belongs to the UPF0403 family
MKMBIGCO_02904	1.37e-173	artP	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MKMBIGCO_02905	1.04e-141	artQ	-	-	E	ko:K02029	-	ko00000,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MKMBIGCO_02906	6.07e-165	artM	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MKMBIGCO_02907	3.22e-219	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
MKMBIGCO_02908	3.7e-123	yqjB	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02910	1.89e-95	mce	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	COG0346 Lactoylglutathione lyase and related lyases
MKMBIGCO_02911	0.0	yqjD	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
MKMBIGCO_02912	6.13e-258	yqjE	3.4.11.14, 3.4.11.4	-	E	ko:K01258,ko:K01263	-	ko00000,ko01000,ko01002	COG2195 Di- and tripeptidases
MKMBIGCO_02913	2.91e-191	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MKMBIGCO_02914	1.3e-34	yqzJ	-	-	-	-	-	-	-
MKMBIGCO_02915	1.35e-301	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKMBIGCO_02916	0.0	gnd	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MKMBIGCO_02917	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKMBIGCO_02918	3.23e-219	rnz	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
MKMBIGCO_02919	5.05e-186	yqjL	-	-	S	-	-	-	hydrolases or acyltransferases (alpha beta hydrolase superfamily)
MKMBIGCO_02920	9.28e-248	namA	1.6.99.1	-	C	ko:K00354	-	ko00000,ko01000	Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes
MKMBIGCO_02921	2.24e-66	-	-	-	S	-	-	-	GlpM protein
MKMBIGCO_02922	6.22e-209	-	-	-	K	-	-	-	LysR substrate binding domain
MKMBIGCO_02923	4.32e-122	nusG1	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
MKMBIGCO_02924	0.0	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	malonyl CoA-acyl carrier protein transacylase
MKMBIGCO_02927	3.73e-312	-	6.1.3.1, 6.2.1.3, 6.2.1.34	-	IQ	ko:K00666,ko:K01897,ko:K12508,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MKMBIGCO_02928	1.54e-165	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
MKMBIGCO_02929	9.07e-279	glcP1	-	-	G	ko:K08174	-	ko00000,ko02000	Major Facilitator Superfamily
MKMBIGCO_02930	5.18e-313	gabT	2.6.1.19	-	E	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKMBIGCO_02931	2.38e-225	suhB	3.1.3.25, 3.1.3.7	-	G	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	ko00000,ko00001,ko00002,ko01000,ko03016	inositol monophosphate 1-phosphatase activity
MKMBIGCO_02932	6.88e-257	-	1.1.1.14, 1.1.1.303, 1.1.1.4	-	E	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
MKMBIGCO_02933	2.74e-288	ybaR	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
MKMBIGCO_02934	2.09e-220	ybaS	-	-	S	-	-	-	Na -dependent transporter
MKMBIGCO_02935	6.15e-140	ybbA	-	-	S	ko:K07017	-	ko00000	Putative esterase
MKMBIGCO_02936	1.43e-229	feuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_02937	4.42e-226	feuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_02938	2.98e-220	feuA	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Iron-uptake system-binding protein
MKMBIGCO_02939	0.0	ybbB	-	-	K	ko:K21701	-	ko00000,ko03000	COG2207 AraC-type DNA-binding domain-containing proteins
MKMBIGCO_02940	1.06e-298	ybbC	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02941	0.0	ybbD	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Belongs to the glycosyl hydrolase 3 family
MKMBIGCO_02942	3.79e-310	ybbE	3.4.16.4	-	V	ko:K21469	ko00550,map00550	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the UPF0214 family
MKMBIGCO_02943	4.31e-312	ybbF	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
MKMBIGCO_02944	3.68e-205	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MKMBIGCO_02945	1.01e-109	ybbJ	-	-	J	-	-	-	acetyltransferase
MKMBIGCO_02946	3.89e-101	ybbK	-	-	S	-	-	-	Protein of unknown function (DUF523)
MKMBIGCO_02952	4.59e-127	sigW	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_02953	3.19e-151	rsiW	-	-	K	-	-	-	Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation
MKMBIGCO_02954	1.82e-187	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MKMBIGCO_02955	8.64e-299	ybbR	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_02956	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKMBIGCO_02957	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
MKMBIGCO_02958	6.13e-199	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
MKMBIGCO_02959	8.23e-138	-	-	-	S	-	-	-	ABC-2 family transporter protein
MKMBIGCO_02960	9.2e-126	ybdN	-	-	-	-	-	-	-
MKMBIGCO_02961	1.06e-165	ybdO	-	-	S	-	-	-	Domain of unknown function (DUF4885)
MKMBIGCO_02962	2.43e-205	dkgB	-	-	S	-	-	-	Aldo/keto reductase family
MKMBIGCO_02963	6.05e-135	yxaC	-	-	M	-	-	-	effector of murein hydrolase
MKMBIGCO_02964	2.32e-66	-	-	-	S	ko:K06518	-	ko00000,ko02000	LrgA family
MKMBIGCO_02965	5.62e-93	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_02966	0.0	ybxG	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_02967	2.51e-117	yfnB	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
MKMBIGCO_02968	7.94e-252	-	-	-	T	-	-	-	COG4585 Signal transduction histidine kinase
MKMBIGCO_02969	7.12e-142	yfiK	-	-	KT	ko:K02479	-	ko00000,ko02022	LuxR family transcriptional regulator
MKMBIGCO_02970	5.1e-213	yfiL	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
MKMBIGCO_02971	2.05e-259	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
MKMBIGCO_02972	1.64e-246	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
MKMBIGCO_02973	1.87e-32	-	-	-	-	-	-	-	-
MKMBIGCO_02974	6.33e-104	-	-	-	S	-	-	-	Domain of unknown function (DUF4879)
MKMBIGCO_02975	7.13e-52	csgA	-	-	S	-	-	-	Sigma-G-dependent sporulation-specific SASP protein
MKMBIGCO_02976	2.93e-143	yqeB	-	-	-	-	-	-	-
MKMBIGCO_02977	7.84e-55	ybyB	-	-	-	-	-	-	-
MKMBIGCO_02978	0.0	ybeC	-	-	E	-	-	-	amino acid
MKMBIGCO_02979	4.93e-212	glpQ	3.1.3.1, 3.1.4.46	-	C	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	glycerophosphoryl diester phosphodiesterase
MKMBIGCO_02980	0.0	glpT	-	-	G	ko:K02445	-	ko00000,ko02000	-transporter
MKMBIGCO_02981	4.08e-23	-	-	-	S	-	-	-	Protein of unknown function (DUF2651)
MKMBIGCO_02982	4.74e-266	yoaI	1.14.14.9	-	Q	ko:K00483	ko00350,ko01120,ko01220,map00350,map01120,map01220	ko00000,ko00001,ko01000	COG2368 Aromatic ring hydroxylase
MKMBIGCO_02984	0.0	ybfG	-	-	M	-	-	-	Domain of unknown function (DUF1906)
MKMBIGCO_02985	1.05e-46	-	-	-	-	-	-	-	-
MKMBIGCO_02986	1.69e-107	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
MKMBIGCO_02987	2.55e-247	ypjH	-	-	C	ko:K08317	-	ko00000,ko01000	COG0371 Glycerol dehydrogenase and related enzymes
MKMBIGCO_02988	6.53e-271	purT	2.1.2.2	-	F	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MKMBIGCO_02989	3.15e-120	pssA	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKMBIGCO_02990	4.26e-113	ybfM	-	-	S	-	-	-	SNARE associated Golgi protein
MKMBIGCO_02991	1.24e-193	psd	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
MKMBIGCO_02992	1.5e-55	ybfN	-	-	-	-	-	-	-
MKMBIGCO_02993	9.56e-244	ybfQ	-	-	S	ko:K07146	-	ko00000	Belongs to the UPF0176 family
MKMBIGCO_02994	6.75e-271	gltP	-	-	C	ko:K11102	-	ko00000,ko02000	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
MKMBIGCO_02995	1.44e-255	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
MKMBIGCO_02996	0.0	ybgF	-	-	E	ko:K02205,ko:K03293,ko:K16235,ko:K16236	-	ko00000,ko02000	amino acid
MKMBIGCO_02997	2.92e-230	mmuM	2.1.1.10	-	H	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	ko00000,ko00001,ko01000	homocysteine
MKMBIGCO_02998	0.0	agcS	-	-	E	ko:K03310,ko:K11626	ko02020,map02020	ko00000,ko00001	Sodium alanine symporter
MKMBIGCO_02999	3.06e-238	glsA	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Belongs to the glutaminase family
MKMBIGCO_03000	1.5e-270	glnJ	2.7.13.3	-	T	ko:K07717	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03001	4.77e-220	glnL	-	-	T	ko:K07719	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Regulator
MKMBIGCO_03002	2.39e-11	ycbJ	-	-	S	ko:K06979	-	br01600,ko00000,ko00002,ko01504	Macrolide 2'-phosphotransferase
MKMBIGCO_03003	1.03e-93	ycbJ	-	-	S	ko:K06979	-	br01600,ko00000,ko00002,ko01504	Macrolide 2'-phosphotransferase
MKMBIGCO_03004	2.81e-34	rtpA	-	-	K	-	-	-	Tryptophan RNA-binding attenuator protein inhibitory protein
MKMBIGCO_03005	7.1e-197	ydfM	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKMBIGCO_03006	1.57e-141	ydfN	-	-	C	ko:K15976	-	ko00000,ko01000	nitroreductase
MKMBIGCO_03007	1.24e-234	ydfO	-	-	E	ko:K15975	-	ko00000	COG0346 Lactoylglutathione lyase and related lyases
MKMBIGCO_03008	4.64e-83	ydfP	-	-	S	ko:K15977	-	ko00000	DoxX
MKMBIGCO_03009	5.37e-74	ydfQ	-	-	CO	-	-	-	Thioredoxin
MKMBIGCO_03010	1.63e-82	ycbP	-	-	S	-	-	-	Protein of unknown function (DUF2512)
MKMBIGCO_03011	1.75e-100	cwlJ	3.5.1.28	-	M	ko:K01449	-	ko00000,ko01000	Cell wall
MKMBIGCO_03012	0.0	phoD	3.1.3.1	-	P	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG3540 Phosphodiesterase alkaline phosphatase D
MKMBIGCO_03013	8.68e-36	tatAD	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
MKMBIGCO_03014	5.31e-155	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKMBIGCO_03015	1.91e-151	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MKMBIGCO_03016	1.84e-261	ycbU	-	-	E	-	-	-	Selenocysteine lyase
MKMBIGCO_03017	2.5e-313	lmrB	-	-	EGP	ko:K18926	-	ko00000,ko00002,ko02000	the major facilitator superfamily
MKMBIGCO_03018	6.03e-128	lmrA	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Transcriptional regulator
MKMBIGCO_03019	1.21e-248	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D
MKMBIGCO_03020	8.07e-148	lip	3.1.1.3	-	S	ko:K01046	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko00002,ko01000	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MKMBIGCO_03021	1.61e-250	yccF	-	-	K	ko:K07039	-	ko00000	SEC-C motif
MKMBIGCO_03022	7.3e-217	yccK	-	-	C	-	-	-	Aldo keto reductase
MKMBIGCO_03023	2.66e-225	ycdA	-	-	S	-	-	-	Domain of unknown function (DUF5105)
MKMBIGCO_03024	0.0	ycdB	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_03025	0.0	ycdC	-	-	K	ko:K03088	-	ko00000,ko03021	Belongs to the sigma-70 factor family. ECF subfamily
MKMBIGCO_03026	1.72e-119	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
MKMBIGCO_03027	2.86e-248	rapJ	-	-	S	ko:K06368	-	ko00000,ko01000	Response regulator aspartate phosphatase
MKMBIGCO_03028	4.28e-179	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
MKMBIGCO_03029	0.0	malL	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
MKMBIGCO_03030	7.35e-214	adcA	-	-	P	ko:K09815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
MKMBIGCO_03031	2.82e-170	adcC	-	-	P	ko:K02074,ko:K09817	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	'COG1121 ABC-type Mn Zn transport systems, ATPase component'
MKMBIGCO_03032	6.86e-174	adcB	-	-	P	ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1108 ABC-type Mn2 Zn2 transport systems, permease components
MKMBIGCO_03033	3.3e-235	yceB	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_03034	4.06e-140	yceC	3.5.4.33	-	T	ko:K11991	-	ko00000,ko01000,ko03016	proteins involved in stress response, homologs of TerZ and
MKMBIGCO_03035	7.32e-136	yceD	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
MKMBIGCO_03036	2.46e-138	yceE	-	-	T	ko:K05795	-	ko00000	proteins involved in stress response, homologs of TerZ and
MKMBIGCO_03037	2.12e-178	yceF	-	-	P	ko:K05794	-	ko00000	Protein of unknown function (DUF475)
MKMBIGCO_03038	0.0	yceG	-	-	S	-	-	-	Putative component of 'biosynthetic module'
MKMBIGCO_03039	1.12e-244	yceH	-	-	P	-	-	-	Belongs to the TelA family
MKMBIGCO_03040	3.52e-274	yceI	-	-	P	ko:K08369	-	ko00000,ko02000	Uncharacterised MFS-type transporter YbfB
MKMBIGCO_03041	7.71e-294	opuAA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
MKMBIGCO_03042	2.45e-185	opuAB	-	-	P	ko:K02001	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
MKMBIGCO_03043	1.16e-209	opuAC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
MKMBIGCO_03044	7.29e-267	amhX	-	-	S	ko:K14665	-	ko00000,ko01000,ko01002	amidohydrolase
MKMBIGCO_03045	1.48e-289	ycgA	-	-	S	-	-	-	Membrane
MKMBIGCO_03046	2.55e-105	ycgB	-	-	-	-	-	-	-
MKMBIGCO_03047	0.0	amyE	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	alpha-amylase
MKMBIGCO_03048	8.99e-226	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
MKMBIGCO_03049	0.0	mdr	-	-	EGP	-	-	-	the major facilitator superfamily
MKMBIGCO_03050	6.92e-101	ycgE	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_03051	3.57e-144	ycgF	-	-	E	-	-	-	Lysine exporter protein LysE YggA
MKMBIGCO_03052	1.71e-191	yqcI	-	-	S	ko:K09190	-	ko00000	YqcI/YcgG family
MKMBIGCO_03053	3.84e-313	ycgH	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_03054	3.22e-146	ycgI	-	-	S	ko:K09967	-	ko00000	Domain of unknown function (DUF1989)
MKMBIGCO_03055	1.29e-191	nadE	6.3.1.5	-	H	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
MKMBIGCO_03056	3.92e-06	-	-	-	S	-	-	-	Bacillus cereus group antimicrobial protein
MKMBIGCO_03057	2.74e-140	tmrB	-	-	S	-	-	-	AAA domain
MKMBIGCO_03058	2.22e-187	-	4.2.1.118	-	G	ko:K15652	ko00400,ko01110,ko01130,map00400,map01110,map01130	ko00000,ko00001,ko01000	Xylose isomerase-like TIM barrel
MKMBIGCO_03059	2.02e-289	-	-	-	G	ko:K08191,ko:K08194	-	ko00000,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_03060	1.01e-134	aroK	2.7.1.71	-	F	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MKMBIGCO_03061	8.08e-234	cah	3.1.1.41	-	Q	ko:K01060	ko00311,ko01130,map00311,map01130	ko00000,ko00001,ko01000	Acetyl xylan esterase (AXE1)
MKMBIGCO_03062	5.05e-188	ycgL	-	-	S	ko:K07074	-	ko00000	Predicted nucleotidyltransferase
MKMBIGCO_03063	1.12e-215	ycgM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
MKMBIGCO_03064	0.0	rocA	1.2.1.88	-	C	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family. RocA subfamily
MKMBIGCO_03065	1.1e-311	putP	-	-	E	ko:K11928	-	ko00000,ko02000	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKMBIGCO_03066	1.43e-290	ycgP	-	-	QT	-	-	-	COG2508 Regulator of polyketide synthase expression
MKMBIGCO_03067	1.93e-241	ycgT	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
MKMBIGCO_03068	0.0	nasF	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the precorrin methyltransferase family
MKMBIGCO_03069	5.73e-73	nasE	1.7.1.15	-	P	ko:K00363	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite reductase
MKMBIGCO_03070	0.0	nasD	1.7.1.15	-	C	ko:K00362	ko00910,ko01120,map00910,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKMBIGCO_03071	3.21e-286	yciC	-	-	S	-	-	-	GTPases (G3E family)
MKMBIGCO_03072	1.02e-280	fdh	1.1.1.1, 1.1.1.284	-	E	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	ko00000,ko00001,ko01000	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
MKMBIGCO_03073	1.32e-94	yckC	-	-	S	-	-	-	membrane
MKMBIGCO_03074	1.46e-64	-	-	-	S	-	-	-	Protein of unknown function (DUF2680)
MKMBIGCO_03075	1.58e-13	yckE	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
MKMBIGCO_03076	1.27e-86	nin	-	-	S	-	-	-	Competence protein J (ComJ)
MKMBIGCO_03077	1.88e-101	nucA	-	-	M	-	-	-	Deoxyribonuclease NucA/NucB
MKMBIGCO_03078	1.54e-124	hxlB	5.3.1.27	-	G	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
MKMBIGCO_03079	1.05e-137	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	3-hexulose-6-phosphate synthase
MKMBIGCO_03080	1.38e-82	hxlR	-	-	K	-	-	-	transcriptional
MKMBIGCO_03081	0.0	srfAA	-	-	Q	ko:K15654,ko:K15655,ko:K16119	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_03082	0.0	srfAB	-	-	Q	ko:K15654,ko:K15655,ko:K16120	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_03083	0.0	srfAC	-	-	Q	ko:K15656,ko:K16121	ko01054,ko02024,map01054,map02024	ko00000,ko00001,ko01008	COG1020 Non-ribosomal peptide synthetase modules and related proteins
MKMBIGCO_03084	6.15e-180	srfAD	-	-	Q	ko:K15657	ko02024,map02024	ko00000,ko00001,ko01008	thioesterase
MKMBIGCO_03085	2.48e-315	-	-	-	E	-	-	-	Aminotransferase class I and II
MKMBIGCO_03086	5.28e-167	sfp	-	-	H	ko:K06133	ko00770,map00770	ko00000,ko00001,ko01000	Belongs to the P-Pant transferase superfamily
MKMBIGCO_03087	9.99e-141	yczE	-	-	S	ko:K07149	-	ko00000	membrane
MKMBIGCO_03088	3.95e-169	tcyC	-	-	E	ko:K10010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MKMBIGCO_03089	4.99e-154	tcyB	-	-	P	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MKMBIGCO_03090	2.8e-187	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
MKMBIGCO_03091	5.96e-206	yclA	-	-	K	ko:K21755	-	ko00000,ko03000	LysR substrate binding domain
MKMBIGCO_03092	1.4e-129	ubiX	2.5.1.129	-	H	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
MKMBIGCO_03093	0.0	yclC	4.1.1.61, 4.1.1.98	-	H	ko:K01612,ko:K03182,ko:K16874	ko00130,ko00365,ko00627,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map01100,map01110,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate
MKMBIGCO_03094	4.71e-51	-	4.1.1.61	-	S	ko:K21759	ko00627,ko01120,ko01220,map00627,map01120,map01220	ko00000,ko00001,ko01000	response to toxic substance
MKMBIGCO_03095	1.67e-100	yclD	-	-	-	-	-	-	-
MKMBIGCO_03096	0.0	dtpT	-	-	E	ko:K03305	-	ko00000	amino acid peptide transporter
MKMBIGCO_03097	0.0	yclG	-	-	M	-	-	-	Pectate lyase superfamily protein
MKMBIGCO_03099	0.0	gerKA	-	-	EG	ko:K06295	-	ko00000	Spore germination protein
MKMBIGCO_03100	2.31e-299	gerKC	-	-	S	ko:K06297	-	ko00000	spore germination
MKMBIGCO_03101	2.27e-249	gerKB	-	-	F	ko:K06296	-	ko00000,ko02000	Spore germination protein
MKMBIGCO_03102	0.0	yxeK	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_03103	6.05e-118	yxeL	-	-	K	-	-	-	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MKMBIGCO_03104	1.43e-179	yxeM	-	-	M	ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 3 family
MKMBIGCO_03105	2.11e-148	yxeN	-	-	P	ko:K10009,ko:K16962	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0765 ABC-type amino acid transport system, permease component
MKMBIGCO_03106	5.6e-170	yxeO	-	-	P	ko:K16960,ko:K16963	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03107	1.97e-276	yxeP	-	-	E	ko:K21613	-	ko00000,ko01000,ko01002	hydrolase activity
MKMBIGCO_03108	6.13e-313	yxeQ	-	-	S	-	-	-	MmgE/PrpD family
MKMBIGCO_03109	3.66e-155	yclH	-	-	P	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
MKMBIGCO_03110	1.74e-309	yclI	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease) YclI
MKMBIGCO_03111	3.04e-163	yclJ	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_03112	0.0	yclK	-	-	T	-	-	-	COG0642 Signal transduction histidine kinase
MKMBIGCO_03113	2.72e-98	rapA1	-	-	S	ko:K06359,ko:K06361	ko02024,map02024	ko00000,ko00001,ko01000	aspartate phosphatase
MKMBIGCO_03115	4.58e-316	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MKMBIGCO_03116	1.1e-210	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_03117	1.4e-212	yclO	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_03118	1.61e-175	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03119	3.24e-222	yclQ	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4607 ABC-type enterochelin transport system, periplasmic component
MKMBIGCO_03120	3.99e-313	ycnB	-	-	EGP	-	-	-	the major facilitator superfamily
MKMBIGCO_03121	1.23e-194	ycnC	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03122	1.38e-174	-	1.5.1.39	-	C	ko:K10678,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	ko00000,ko00001,ko01000	Nitroreductase family
MKMBIGCO_03123	1.97e-59	ycnE	-	-	S	-	-	-	Monooxygenase
MKMBIGCO_03124	3.92e-70	yczG	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MKMBIGCO_03125	0.0	gabR	-	-	K	ko:K00375	-	ko00000,ko03000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MKMBIGCO_03126	1.71e-284	gabT	2.6.1.19, 2.6.1.22	-	E	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKMBIGCO_03127	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively
MKMBIGCO_03128	8.27e-191	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	Glucose uptake
MKMBIGCO_03129	2.4e-186	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_03130	4.83e-130	ycnI	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_03131	0.0	ycnJ	-	-	P	ko:K14166	-	ko00000,ko02000	protein, homolog of Cu resistance protein CopC
MKMBIGCO_03132	4.98e-137	ycnK	-	-	K	ko:K21601	-	ko00000,ko03000	COG1349 Transcriptional regulators of sugar metabolism
MKMBIGCO_03133	9.6e-73	-	-	-	-	-	-	-	-
MKMBIGCO_03134	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG2213 Phosphotransferase system, mannitol-specific IIBC component
MKMBIGCO_03135	4.11e-95	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG4668 Mannitol fructose-specific phosphotransferase system, IIA domain
MKMBIGCO_03136	1.06e-259	mtlD	1.1.1.17	-	G	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	COG0246 Mannitol-1-phosphate altronate dehydrogenases
MKMBIGCO_03137	2.89e-87	ycsD	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
MKMBIGCO_03139	2.69e-177	ycsE	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
MKMBIGCO_03140	7.14e-180	ycsF	-	-	S	ko:K07160	-	ko00000	Belongs to the UPF0271 (lamB) family
MKMBIGCO_03141	2.54e-269	ycsG	-	-	P	-	-	-	COG1914 Mn2 and Fe2 transporters of the NRAMP family
MKMBIGCO_03142	1.15e-190	ycsI	-	-	S	-	-	-	Belongs to the D-glutamate cyclase family
MKMBIGCO_03143	6.36e-173	kipI	-	-	E	ko:K06351	-	ko00000	Allophanate hydrolase subunit 1
MKMBIGCO_03144	4.91e-240	kipA	-	-	E	ko:K06350	-	ko00000	Allophanate hydrolase subunit 2
MKMBIGCO_03145	4.65e-167	kipR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03146	3.86e-150	ycsK	-	-	E	-	-	-	anatomical structure formation involved in morphogenesis
MKMBIGCO_03148	5.95e-75	yczJ	-	-	S	-	-	-	biosynthesis
MKMBIGCO_03149	0.0	pbpC	3.4.16.4	-	M	ko:K02545,ko:K21467	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	Penicillin-binding Protein
MKMBIGCO_03150	3e-220	ycsN	-	-	S	-	-	-	Oxidoreductase
MKMBIGCO_03151	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	transcriptional regulator, MtlR
MKMBIGCO_03152	0.0	ydaB	-	-	IQ	-	-	-	acyl-CoA ligase
MKMBIGCO_03153	1.28e-205	ydaD	-	-	IQ	-	-	-	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_03154	3.91e-125	ydaE	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Cupin 2, conserved barrel domain protein
MKMBIGCO_03155	4.04e-149	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
MKMBIGCO_03156	1.83e-101	ydaG	-	-	S	-	-	-	general stress protein
MKMBIGCO_03157	7.59e-178	amj	-	-	U	-	-	-	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
MKMBIGCO_03158	6.54e-63	ydzA	-	-	EGP	-	-	-	Domain of unknown function (DUF3817)
MKMBIGCO_03159	3.25e-97	lrpC	-	-	K	ko:K03719	-	ko00000,ko03000,ko03036	Transcriptional regulator
MKMBIGCO_03160	0.0	topB	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKMBIGCO_03161	1.56e-255	ydaJ	-	-	M	-	-	-	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MKMBIGCO_03162	2.19e-188	ydaK	-	-	T	-	-	-	Diguanylate cyclase, GGDEF domain
MKMBIGCO_03163	0.0	ydaL	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2334)
MKMBIGCO_03164	2.63e-302	ydaM	-	-	M	-	-	-	Glycosyl transferase family group 2
MKMBIGCO_03165	0.0	ydaN	-	-	S	-	-	-	Bacterial cellulose synthase subunit
MKMBIGCO_03166	0.0	ydaO	-	-	E	-	-	-	amino acid
MKMBIGCO_03167	8.5e-95	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MKMBIGCO_03168	0.0	ydaP	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
MKMBIGCO_03169	1.68e-57	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	N-acetylmuramoyl-L-alanine amidase
MKMBIGCO_03170	1.26e-98	-	-	-	-	-	-	-	-
MKMBIGCO_03172	2.25e-265	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Histidine kinase
MKMBIGCO_03174	2.7e-19	-	-	-	-	-	-	-	-
MKMBIGCO_03176	4.89e-112	-	-	-	-	-	-	-	-
MKMBIGCO_03177	1.41e-128	-	-	-	-	-	-	-	-
MKMBIGCO_03178	7.18e-52	-	-	-	-	-	-	-	-
MKMBIGCO_03179	5.35e-288	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
MKMBIGCO_03181	1.95e-45	ydaT	-	-	-	-	-	-	-
MKMBIGCO_03182	4.08e-71	yvaE	-	-	P	ko:K03297	-	ko00000,ko02000	Small Multidrug Resistance protein
MKMBIGCO_03183	2.19e-181	ydbA	-	-	P	-	-	-	EcsC protein family
MKMBIGCO_03184	5.59e-17	res	-	-	L	-	-	-	Resolvase, N terminal domain
MKMBIGCO_03185	1.09e-65	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
MKMBIGCO_03186	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	Type I restriction-modification system
MKMBIGCO_03187	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
MKMBIGCO_03191	1.85e-115	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
MKMBIGCO_03192	4.55e-131	rdgB	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MKMBIGCO_03193	4.12e-170	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MKMBIGCO_03194	2.58e-254	gerM	-	-	S	ko:K06298	-	ko00000	COG5401 Spore germination protein
MKMBIGCO_03195	1.15e-196	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
MKMBIGCO_03196	1.08e-96	ysmB	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
MKMBIGCO_03197	6.32e-42	gerE	-	-	K	ko:K01994	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_03198	2.19e-100	ysmA	-	-	S	ko:K07107	-	ko00000,ko01000	thioesterase
MKMBIGCO_03199	4.34e-189	sdhB	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
MKMBIGCO_03200	0.0	sdhA	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	succinate dehydrogenase
MKMBIGCO_03201	2.73e-140	sdhC	-	-	C	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	succinate dehydrogenase
MKMBIGCO_03202	7.02e-103	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
MKMBIGCO_03203	1.01e-273	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
MKMBIGCO_03204	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
MKMBIGCO_03205	1.6e-69	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
MKMBIGCO_03206	0.0	xsa	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	Alpha-L-arabinofuranosidase C-terminus
MKMBIGCO_03207	1.43e-226	etfA	-	-	C	ko:K03522	-	ko00000,ko04147	Electron transfer flavoprotein
MKMBIGCO_03208	4.1e-176	etfB	-	-	C	ko:K03521	-	ko00000	Electron transfer flavoprotein
MKMBIGCO_03209	1.43e-177	fadB	4.2.1.17	-	I	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the enoyl-CoA hydratase isomerase family
MKMBIGCO_03210	1.78e-133	fadR	-	-	K	ko:K13770	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_03211	0.0	lcfA	6.2.1.3	-	IQ	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
MKMBIGCO_03212	4.82e-114	ywbB	-	-	S	-	-	-	Protein of unknown function (DUF2711)
MKMBIGCO_03213	3.09e-88	yshE	-	-	S	ko:K08989	-	ko00000	membrane
MKMBIGCO_03214	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
MKMBIGCO_03215	0.0	polX	-	-	L	ko:K02347	-	ko00000,ko03400	COG1796 DNA polymerase IV (family X)
MKMBIGCO_03216	1.42e-107	yshB	-	-	S	-	-	-	membrane protein, required for colicin V production
MKMBIGCO_03217	4.23e-54	zapA	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MKMBIGCO_03218	7.57e-216	rnhC	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKMBIGCO_03219	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MKMBIGCO_03220	2.19e-249	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MKMBIGCO_03221	4.63e-173	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKMBIGCO_03222	1.07e-43	sspI	-	-	S	ko:K06426	-	ko00000	Belongs to the SspI family
MKMBIGCO_03223	2.81e-258	cdaR_1	-	-	KT	ko:K02647	-	ko00000,ko03000	regulator
MKMBIGCO_03224	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD binding domain
MKMBIGCO_03225	0.0	glcF	-	-	C	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001	Glycolate oxidase
MKMBIGCO_03226	0.0	cstA	-	-	T	ko:K06200	-	ko00000	Carbon starvation protein
MKMBIGCO_03227	0.0	abfA	3.2.1.55	GH51	G	ko:K01209	ko00520,map00520	ko00000,ko00001,ko01000	alpha-L-arabinofuranosidase activity
MKMBIGCO_03228	1.18e-191	araQ	-	-	G	ko:K17236	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transport system permease
MKMBIGCO_03229	1.78e-214	araP	-	-	P	ko:K10189,ko:K10241,ko:K17235	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	PFAM binding-protein-dependent transport systems inner membrane component
MKMBIGCO_03230	0.0	araN	-	-	G	ko:K17234	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	carbohydrate transport
MKMBIGCO_03231	2.24e-283	araM	1.1.1.261	-	I	ko:K00096	ko00564,map00564	ko00000,ko00001,ko01000	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species
MKMBIGCO_03232	2.93e-179	araL	-	-	G	ko:K02101	-	ko00000	Haloacid dehalogenase-like hydrolase
MKMBIGCO_03233	3.43e-170	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
MKMBIGCO_03234	0.0	araB	2.7.1.16	-	C	ko:K00853	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Belongs to the ribulokinase family
MKMBIGCO_03235	0.0	araA	5.3.1.4	-	G	ko:K01804	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of L-arabinose to L-ribulose
MKMBIGCO_03236	8.14e-240	abnA	3.2.1.99	GH43	G	ko:K06113	-	ko00000,ko01000	Belongs to the glycosyl hydrolase 43 family
MKMBIGCO_03237	1.85e-263	ysdC	-	-	G	-	-	-	COG1363 Cellulase M and related proteins
MKMBIGCO_03238	3.13e-86	ysdB	-	-	S	-	-	-	Sigma-w pathway protein YsdB
MKMBIGCO_03239	5.44e-56	ysdA	-	-	S	-	-	-	Membrane
MKMBIGCO_03240	3.26e-76	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MKMBIGCO_03241	1.95e-37	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
MKMBIGCO_03242	1.79e-112	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MKMBIGCO_03243	2.09e-145	lrgB	-	-	M	ko:K05339	ko02020,map02020	ko00000,ko00001	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses
MKMBIGCO_03244	9.13e-66	-	-	-	S	ko:K05338	ko02020,map02020	ko00000,ko00001,ko02000	effector of murein hydrolase LrgA
MKMBIGCO_03245	4.27e-167	lytT	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG3279 Response regulator of the LytR AlgR family
MKMBIGCO_03246	0.0	lytS	2.7.13.3	-	T	ko:K07704	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03247	5.69e-191	ysaA	3.1.3.5, 3.8.1.2	-	S	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
MKMBIGCO_03248	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MKMBIGCO_03249	1.63e-196	ytxC	-	-	S	-	-	-	YtxC-like family
MKMBIGCO_03250	3.51e-137	ytxB	-	-	S	-	-	-	SNARE associated Golgi protein
MKMBIGCO_03251	2.87e-219	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
MKMBIGCO_03252	0.0	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	Membrane attachment protein
MKMBIGCO_03253	5.95e-106	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKMBIGCO_03254	1.82e-88	speH	4.1.1.50	-	E	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MKMBIGCO_03255	8.56e-247	gapB	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MKMBIGCO_03256	1.69e-89	ytcD	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03257	6.56e-258	ytbD	-	-	EGP	ko:K19577	-	ko00000,ko02000	-transporter
MKMBIGCO_03258	4.54e-205	ytbE	-	-	S	-	-	-	reductase
MKMBIGCO_03259	3.43e-127	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MKMBIGCO_03260	5.73e-138	ytaF	-	-	P	-	-	-	Probably functions as a manganese efflux pump
MKMBIGCO_03261	1.64e-201	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
MKMBIGCO_03262	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKMBIGCO_03263	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase
MKMBIGCO_03264	2.9e-167	phoP	-	-	T	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_03265	3.62e-218	mdh	1.1.1.27, 1.1.1.37	-	C	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible oxidation of malate to oxaloacetate
MKMBIGCO_03266	5.36e-308	icd	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	isocitrate
MKMBIGCO_03267	2.86e-268	citZ	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Belongs to the citrate synthase family
MKMBIGCO_03270	1.09e-254	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Aspartate phosphatase response regulator
MKMBIGCO_03271	7.64e-69	-	-	-	-	-	-	-	-
MKMBIGCO_03272	1.84e-81	yjdF3	-	-	S	-	-	-	Protein of unknown function (DUF2992)
MKMBIGCO_03273	5.65e-96	ytwI	-	-	S	-	-	-	membrane
MKMBIGCO_03274	4.05e-247	ytvI	-	-	S	-	-	-	sporulation integral membrane protein YtvI
MKMBIGCO_03275	2.41e-84	fxsA	-	-	S	ko:K07113	-	ko00000	COG3030 Protein affecting phage T7 exclusion by the F plasmid
MKMBIGCO_03276	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
MKMBIGCO_03277	1.14e-229	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
MKMBIGCO_03278	1.34e-231	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
MKMBIGCO_03279	3.59e-207	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MKMBIGCO_03280	2.45e-286	ytsJ	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
MKMBIGCO_03281	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
MKMBIGCO_03282	4.94e-75	ytrH	-	-	S	-	-	-	Sporulation protein YtrH
MKMBIGCO_03283	4.38e-113	ytrI	-	-	-	-	-	-	-
MKMBIGCO_03284	1e-31	-	-	-	-	-	-	-	-
MKMBIGCO_03285	2.14e-231	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	COG0618 Exopolyphosphatase-related proteins
MKMBIGCO_03286	3.57e-62	ytpI	-	-	S	-	-	-	YtpI-like protein
MKMBIGCO_03287	1.29e-301	ytoI	-	-	K	-	-	-	transcriptional regulator containing CBS domains
MKMBIGCO_03288	4.86e-165	ytkL	-	-	S	-	-	-	Belongs to the UPF0173 family
MKMBIGCO_03289	1.98e-182	ytkK	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_03291	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
MKMBIGCO_03292	3.03e-297	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
MKMBIGCO_03293	3.31e-114	moaB	2.7.7.75	-	H	ko:K03638	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000	May be involved in the biosynthesis of molybdopterin
MKMBIGCO_03294	1.57e-279	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKMBIGCO_03295	1.69e-231	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
MKMBIGCO_03296	1.12e-115	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MKMBIGCO_03297	4.77e-100	ytfJ	-	-	S	-	-	-	Sporulation protein YtfJ
MKMBIGCO_03298	1.26e-147	ytfI	-	-	S	-	-	-	Protein of unknown function (DUF2953)
MKMBIGCO_03299	2.77e-114	yteJ	-	-	S	-	-	-	RDD family
MKMBIGCO_03300	6.39e-235	sppA	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	signal peptide peptidase SppA
MKMBIGCO_03301	3.16e-194	nadK2	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKMBIGCO_03302	0.0	ytcJ	-	-	S	-	-	-	amidohydrolase
MKMBIGCO_03303	0.0	ytcI	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MKMBIGCO_03304	2.05e-42	sspB	-	-	S	ko:K06418,ko:K06419	-	ko00000	spore protein
MKMBIGCO_03305	4.05e-285	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKMBIGCO_03306	2.25e-265	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Cysteine desulfurase
MKMBIGCO_03307	1.32e-306	braB	-	-	E	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
MKMBIGCO_03308	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MKMBIGCO_03309	1.46e-196	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	COG1387 Histidinol phosphatase and related hydrolases of the PHP family
MKMBIGCO_03310	2.41e-141	yttP	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03311	2.04e-110	ytsP	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
MKMBIGCO_03312	0.0	ytrP	-	-	T	-	-	-	COG2199 FOG GGDEF domain
MKMBIGCO_03313	5.75e-141	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MKMBIGCO_03314	0.0	ywdH	1.2.1.3	-	C	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MKMBIGCO_03315	2.48e-130	yokH	-	-	G	-	-	-	SMI1 / KNR4 family
MKMBIGCO_03317	4.78e-66	-	-	-	-	-	-	-	-
MKMBIGCO_03320	1.18e-06	-	-	-	S	-	-	-	Phage-like element PBSX protein XtrA
MKMBIGCO_03321	6.07e-20	-	-	-	-	-	-	-	-
MKMBIGCO_03322	8.81e-39	dnaC	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
MKMBIGCO_03323	3.57e-281	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKMBIGCO_03325	1.93e-117	yfkM	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	protease
MKMBIGCO_03327	9.35e-174	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
MKMBIGCO_03328	3.93e-190	-	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKMBIGCO_03329	1.06e-188	-	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03330	9.98e-161	ygaZ	-	-	E	-	-	-	AzlC protein
MKMBIGCO_03331	2.07e-62	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
MKMBIGCO_03332	3.46e-303	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKMBIGCO_03333	0.0	acsA	6.2.1.1	-	I	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko01004	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
MKMBIGCO_03334	2.84e-155	acuA	-	-	K	ko:K04766	-	ko00000,ko01000	Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue
MKMBIGCO_03335	3.42e-149	acuB	-	-	S	ko:K04767	-	ko00000	Domain in cystathionine beta-synthase and other proteins.
MKMBIGCO_03336	9.2e-289	acuC	-	-	BQ	ko:K04768	-	ko00000	histone deacetylase
MKMBIGCO_03337	3.51e-154	ytxE	-	-	N	ko:K02557	ko02030,ko02040,map02030,map02040	ko00000,ko00001,ko02000,ko02035	Flagellar motor protein
MKMBIGCO_03338	5.2e-186	motP	-	-	N	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	ko00000,ko00001,ko02000,ko02035	flagellar motor
MKMBIGCO_03339	5.91e-235	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
MKMBIGCO_03340	1.54e-249	aroA	2.5.1.54, 5.4.99.5	-	E	ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate
MKMBIGCO_03341	5.67e-56	ytxJ	-	-	O	-	-	-	Protein of unknown function (DUF2847)
MKMBIGCO_03342	1.83e-30	ytxH	-	-	S	-	-	-	COG4980 Gas vesicle protein
MKMBIGCO_03343	5.38e-26	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MKMBIGCO_03344	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
MKMBIGCO_03345	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
MKMBIGCO_03346	2.08e-139	ytpR	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
MKMBIGCO_03347	1.69e-190	ytpQ	-	-	S	-	-	-	Belongs to the UPF0354 family
MKMBIGCO_03348	5.47e-76	ytpP	-	-	CO	-	-	-	Thioredoxin
MKMBIGCO_03349	3.91e-100	ytoQ	-	-	S	-	-	-	Nucleoside 2-deoxyribosyltransferase YtoQ
MKMBIGCO_03350	4.33e-260	pepA	3.4.11.7	-	G	ko:K01261,ko:K01269	-	ko00000,ko01000,ko01002	COG1363 Cellulase M and related proteins
MKMBIGCO_03351	9.96e-69	ytzB	-	-	S	-	-	-	small secreted protein
MKMBIGCO_03352	0.0	malS	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malate dehydrogenase
MKMBIGCO_03353	5.12e-207	ytnP	-	-	S	-	-	-	COG0491 Zn-dependent hydrolases, including glyoxylases
MKMBIGCO_03354	6.43e-160	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
MKMBIGCO_03355	3.88e-60	ytzH	-	-	S	-	-	-	YtzH-like protein
MKMBIGCO_03356	2.93e-199	ytmP	-	-	M	-	-	-	Phosphotransferase
MKMBIGCO_03357	1.61e-224	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
MKMBIGCO_03358	3.58e-212	ytlQ	-	-	-	-	-	-	-
MKMBIGCO_03359	6.34e-132	ytlP	3.1.4.58	-	J	ko:K01975	-	ko00000,ko01000,ko03016	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MKMBIGCO_03360	6.81e-222	ytkP	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
MKMBIGCO_03361	0.0	ytjP	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Dipeptidase
MKMBIGCO_03362	1.42e-288	pbuO	-	-	S	ko:K06901	-	ko00000,ko02000	permease
MKMBIGCO_03363	3.53e-276	ythQ	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	Bacterial ABC transporter protein EcsB
MKMBIGCO_03364	5.44e-165	ythP	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
MKMBIGCO_03365	4.46e-46	ytzE	-	-	K	-	-	-	COG1349 Transcriptional regulators of sugar metabolism
MKMBIGCO_03366	8.33e-167	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
MKMBIGCO_03367	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_03368	5.3e-299	ytfP	-	-	S	ko:K07007	-	ko00000	HI0933-like protein
MKMBIGCO_03369	0.0	opuD	-	-	M	ko:K05020	-	ko00000,ko02000	Belongs to the BCCT transporter (TC 2.A.15) family
MKMBIGCO_03370	2.14e-36	yteV	-	-	S	-	-	-	Sporulation protein Cse60
MKMBIGCO_03371	1.29e-237	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
MKMBIGCO_03372	4.42e-308	msmE	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
MKMBIGCO_03373	5.58e-218	-	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MKMBIGCO_03374	2.37e-183	amyC	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter (permease)
MKMBIGCO_03375	9.62e-317	melA	3.2.1.22	-	G	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase
MKMBIGCO_03376	1.98e-110	-	-	-	M	-	-	-	Acetyltransferase (GNAT) domain
MKMBIGCO_03377	6.05e-69	ytwF	-	-	P	-	-	-	Sulfurtransferase
MKMBIGCO_03378	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
MKMBIGCO_03379	7.19e-69	ytvB	-	-	S	-	-	-	Protein of unknown function (DUF4257)
MKMBIGCO_03380	1.32e-174	pfyP	-	-	T	-	-	-	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
MKMBIGCO_03381	6.76e-269	yttB	-	-	EGP	-	-	-	Major facilitator superfamily
MKMBIGCO_03382	1.47e-157	ywaF	-	-	S	-	-	-	Integral membrane protein
MKMBIGCO_03383	0.0	bceB	-	-	V	ko:K02004,ko:K11632,ko:K19080	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter (permease)
MKMBIGCO_03384	3.81e-173	bceA	-	-	V	ko:K02003,ko:K11631,ko:K19079	ko01503,ko02010,ko02020,ko05150,map01503,map02010,map02020,map05150	ko00000,ko00001,ko00002,ko01504,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03385	3.54e-221	bceS	2.7.13.3	-	T	ko:K11629,ko:K19077	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	His Kinase A (phosphoacceptor) domain
MKMBIGCO_03386	3.69e-166	graR	-	-	T	ko:K11630,ko:K19078	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01504,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_03387	3.9e-287	ytrF	-	-	V	ko:K02004,ko:K16918	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0577 ABC-type antimicrobial peptide transport system, permease component
MKMBIGCO_03388	3.01e-161	ytrE	-	-	V	ko:K16920	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03389	1.58e-201	-	-	-	-	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	-
MKMBIGCO_03390	1.19e-231	-	-	-	P	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MKMBIGCO_03391	7.78e-216	ytrC	-	-	S	ko:K16919	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MKMBIGCO_03392	1.03e-207	ytrB	-	-	P	ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03393	2.68e-87	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	GntR family transcriptional regulator
MKMBIGCO_03395	7.09e-53	ytzC	-	-	S	-	-	-	Protein of unknown function (DUF2524)
MKMBIGCO_03396	3.11e-247	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
MKMBIGCO_03397	0.0	-	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_03398	6.73e-244	ytqA	-	-	S	ko:K07139	-	ko00000	Fe-S oxidoreductase
MKMBIGCO_03399	1.26e-136	ytqB	-	-	J	-	-	-	Putative rRNA methylase
MKMBIGCO_03401	4.1e-182	-	3.1.4.46, 5.4.2.11	-	C	ko:K01126,ko:K01834	ko00010,ko00260,ko00564,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00564,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	glycerophosphoryl diester phosphodiesterase
MKMBIGCO_03402	2.02e-271	ytpB	4.2.3.130	-	S	ko:K16188	-	ko00000,ko01000	Tetraprenyl-beta-curcumene synthase
MKMBIGCO_03403	6.95e-194	ytpA	3.1.1.5	-	I	ko:K01048	ko00564,map00564	ko00000,ko00001,ko01000	Alpha beta hydrolase
MKMBIGCO_03404	8.19e-84	ytoA	-	-	S	-	-	-	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MKMBIGCO_03405	0.0	ytnA	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_03406	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
MKMBIGCO_03407	7.88e-287	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MKMBIGCO_03408	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MKMBIGCO_03409	2.85e-52	ytmB	-	-	S	-	-	-	Protein of unknown function (DUF2584)
MKMBIGCO_03410	7.79e-190	ytmA	-	-	E	-	-	-	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases
MKMBIGCO_03411	2.93e-235	ytlA	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
MKMBIGCO_03412	6.12e-184	ytlC	3.6.3.36	-	P	ko:K02049,ko:K10831,ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MKMBIGCO_03413	7.52e-174	ytlD	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component
MKMBIGCO_03414	1.01e-114	ytkD	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	Belongs to the Nudix hydrolase family
MKMBIGCO_03415	3.51e-79	ytkC	-	-	S	-	-	-	Bacteriophage holin family
MKMBIGCO_03416	3e-98	dps	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
MKMBIGCO_03418	4.95e-98	ytkA	-	-	S	-	-	-	YtkA-like
MKMBIGCO_03419	7.16e-114	luxS	4.4.1.21	-	T	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
MKMBIGCO_03420	6.93e-53	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
MKMBIGCO_03421	9.31e-137	ytiB	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
MKMBIGCO_03422	7.13e-56	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
MKMBIGCO_03423	4.48e-313	ythA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	oxidase, subunit
MKMBIGCO_03424	2.23e-236	ythB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
MKMBIGCO_03425	3.2e-33	-	-	-	S	-	-	-	Domain of Unknown Function (DUF1540)
MKMBIGCO_03426	1.17e-271	menC	4.2.1.113	-	H	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
MKMBIGCO_03427	0.0	menE	6.2.1.26	-	H	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
MKMBIGCO_03428	6.18e-199	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MKMBIGCO_03429	2.42e-197	menH	4.2.99.20	-	S	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
MKMBIGCO_03430	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MKMBIGCO_03431	0.0	menF	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
MKMBIGCO_03432	1.18e-166	yteA	-	-	T	-	-	-	COG1734 DnaK suppressor protein
MKMBIGCO_03433	7.42e-102	ytaB	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	membrane
MKMBIGCO_03453	2.93e-233	yvcT	1.1.1.215, 1.1.1.26, 1.1.1.79, 1.1.1.81	-	CH	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKMBIGCO_03454	4.41e-137	yvdA	4.2.1.1	-	P	ko:K01673	ko00910,map00910	ko00000,ko00001,ko01000	Reversible hydration of carbon dioxide
MKMBIGCO_03455	0.0	yvdB	-	-	P	ko:K03321	-	ko00000,ko02000	COG0659 Sulfate permease and related transporters (MFS superfamily)
MKMBIGCO_03456	1.3e-69	yvdC	-	-	S	-	-	-	MazG nucleotide pyrophosphohydrolase domain
MKMBIGCO_03457	3.78e-137	yvdD	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
MKMBIGCO_03459	0.0	-	-	-	EGP	-	-	-	Sugar (and other) transporter
MKMBIGCO_03460	3.21e-267	yraM	-	-	S	-	-	-	PrpF protein
MKMBIGCO_03461	3.34e-210	yraN	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03462	3.74e-136	clpP	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
MKMBIGCO_03463	3.17e-234	scrR	-	-	K	ko:K02529,ko:K03484	-	ko00000,ko03000	transcriptional
MKMBIGCO_03464	4.72e-284	rafB	-	-	P	ko:K02532	-	ko00000,ko02000	LacY proton/sugar symporter
MKMBIGCO_03465	0.0	cscA	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
MKMBIGCO_03467	1.31e-45	-	-	-	-	-	-	-	-
MKMBIGCO_03468	3.94e-125	-	-	-	I	-	-	-	Pfam Lipase (class 3)
MKMBIGCO_03469	2.86e-18	-	-	-	S	-	-	-	Protein of unknown function (DUF1433)
MKMBIGCO_03470	1.01e-120	padC	-	-	Q	ko:K13727	-	ko00000,ko01000	Phenolic acid decarboxylase
MKMBIGCO_03471	3.16e-118	paiA	2.3.1.57	-	K	ko:K22441	-	ko00000,ko01000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
MKMBIGCO_03472	1.06e-145	yyaS	-	-	S	ko:K07149	-	ko00000	Membrane
MKMBIGCO_03473	1.91e-125	ywjB	-	-	H	-	-	-	RibD C-terminal domain
MKMBIGCO_03475	0.0	pnbA	-	CE10	I	ko:K03929	-	ko00000,ko01000	Belongs to the type-B carboxylesterase lipase family
MKMBIGCO_03476	6.96e-100	-	-	-	K	ko:K19417	-	ko00000,ko03000	transcriptional
MKMBIGCO_03477	7.89e-154	epsA	-	-	M	ko:K19420	-	ko00000	biosynthesis protein
MKMBIGCO_03478	3.12e-151	ywqD	2.7.10.2	-	D	ko:K00903	-	ko00000,ko01000,ko01001	COG0489 ATPases involved in chromosome partitioning
MKMBIGCO_03479	0.0	capD	-	-	GM	ko:K19421	-	ko00000	Polysaccharide biosynthesis protein
MKMBIGCO_03480	3.53e-277	epsD	-	GT4	M	ko:K19422	-	ko00000,ko01000	Glycosyl transferase 4-like
MKMBIGCO_03481	3.2e-205	epsE	-	GT2	M	ko:K19423	-	ko00000,ko01000,ko01003	COG0463 Glycosyltransferases involved in cell wall biogenesis
MKMBIGCO_03482	2.88e-271	epsF	-	GT4	M	ko:K19424	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
MKMBIGCO_03483	6.95e-262	epsG	-	-	S	ko:K19419	-	ko00000,ko02000	EpsG family
MKMBIGCO_03484	1.41e-243	epsH	-	GT2	S	ko:K19425	-	ko00000,ko01000,ko01003	Glycosyltransferase like family 2
MKMBIGCO_03485	5.47e-259	epsI	-	-	GM	ko:K19426	-	ko00000,ko01000	pyruvyl transferase
MKMBIGCO_03486	4.97e-248	epsJ	-	GT2	S	ko:K19427	-	ko00000,ko01000	COG0463 Glycosyltransferases involved in cell wall biogenesis
MKMBIGCO_03487	0.0	epsK	-	-	S	ko:K19418	-	ko00000,ko02000	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
MKMBIGCO_03488	7.83e-140	epsL	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
MKMBIGCO_03489	6.24e-76	epsM	-	-	GM	ko:K19429	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
MKMBIGCO_03490	2.61e-280	epsN	-	-	E	ko:K19430	-	ko00000,ko01000	Belongs to the DegT DnrJ EryC1 family
MKMBIGCO_03491	3.71e-236	epsO	-	-	GM	ko:K19431	-	ko00000,ko01000	Exopolysaccharide biosynthesis protein
MKMBIGCO_03492	4.01e-44	yvfG	-	-	S	-	-	-	YvfG protein
MKMBIGCO_03493	5.15e-306	rpoN	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
MKMBIGCO_03494	0.0	lctP	-	-	C	ko:K03303	-	ko00000,ko02000	L-lactate permease
MKMBIGCO_03495	3.62e-155	yvfI	-	-	K	ko:K05799	-	ko00000,ko03000	COG2186 Transcriptional regulators
MKMBIGCO_03496	8.05e-278	-	-	-	EK	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	ko00000,ko00001,ko01000	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
MKMBIGCO_03497	2.14e-173	lutA	-	-	C	ko:K18928	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MKMBIGCO_03498	0.0	lutB	-	-	C	ko:K18929	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate
MKMBIGCO_03499	9.73e-171	lutC	-	-	S	ko:K00782	-	ko00000	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source
MKMBIGCO_03500	1.6e-289	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	COG2610 H gluconate symporter and related permeases
MKMBIGCO_03501	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
MKMBIGCO_03502	1.82e-193	gntR	-	-	K	-	-	-	RpiR family transcriptional regulator
MKMBIGCO_03504	9.5e-275	yvbW	-	-	E	ko:K03293	-	ko00000	COG1113 Gamma-aminobutyrate permease and related permeases
MKMBIGCO_03505	2.13e-202	yvbV	-	-	EG	-	-	-	EamA-like transporter family
MKMBIGCO_03506	1.51e-200	yvbU	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03508	7.57e-243	yvbT	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_03509	1.11e-260	araR	-	-	K	ko:K02103	-	ko00000,ko03000	transcriptional
MKMBIGCO_03510	0.0	araE	-	-	U	ko:K02100,ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
MKMBIGCO_03512	2.95e-240	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
MKMBIGCO_03513	2.83e-238	gapA	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
MKMBIGCO_03514	3.98e-277	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
MKMBIGCO_03515	2.58e-177	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
MKMBIGCO_03516	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of 2-phosphoglycerate and
MKMBIGCO_03517	9.69e-310	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
MKMBIGCO_03519	2.45e-252	lcnDR2	-	-	V	-	-	-	Lanthionine synthetase C-like protein
MKMBIGCO_03521	5.67e-225	lcnDR2	-	-	V	-	-	-	Lanthionine synthetase C-like protein
MKMBIGCO_03522	3.19e-239	lanT	-	-	V	ko:K06148,ko:K13409,ko:K20344,ko:K20386	ko02010,ko02024,ko04626,map02010,map02024,map04626	ko00000,ko00001,ko00002,ko02000,ko02044	Peptidase C39 family
MKMBIGCO_03525	4.52e-106	yvbK	-	-	K	-	-	-	acetyltransferase
MKMBIGCO_03526	0.0	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
MKMBIGCO_03527	1.21e-153	yvbI	-	-	M	-	-	-	Membrane
MKMBIGCO_03528	4.44e-134	yvbG	-	-	U	ko:K05595	-	ko00000,ko02000	UPF0056 membrane protein
MKMBIGCO_03529	2.38e-128	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
MKMBIGCO_03530	5.16e-270	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MKMBIGCO_03531	1.61e-144	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MKMBIGCO_03532	3.25e-222	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MKMBIGCO_03533	5.95e-139	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MKMBIGCO_03534	3.42e-124	-	-	-	K	ko:K22301	-	ko00000,ko03000	Belongs to the GbsR family
MKMBIGCO_03535	3.73e-264	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1125 ABC-type proline glycine betaine transport systems, ATPase components
MKMBIGCO_03536	3.4e-146	opuCB	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MKMBIGCO_03537	7.34e-219	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
MKMBIGCO_03538	1.21e-143	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1174 ABC-type proline glycine betaine transport systems, permease component
MKMBIGCO_03539	3.64e-160	spaF	-	-	V	ko:K01990,ko:K20459,ko:K20490	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03540	5.48e-154	spaE	-	-	S	ko:K20491	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MKMBIGCO_03541	5.53e-167	spaG	-	-	S	ko:K20492	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko00002,ko02000	ABC-2 family transporter protein
MKMBIGCO_03542	1.29e-156	spaR	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
MKMBIGCO_03543	0.0	spaK	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
MKMBIGCO_03544	2.97e-70	yvaP	-	-	K	-	-	-	transcriptional
MKMBIGCO_03545	3.52e-96	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	Cro/C1-type HTH DNA-binding domain
MKMBIGCO_03546	2.73e-92	yvaO	-	-	K	ko:K22299	-	ko00000,ko03000	transcriptional
MKMBIGCO_03547	1.64e-47	yvzC	-	-	K	-	-	-	transcriptional
MKMBIGCO_03548	4.58e-36	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit SecG
MKMBIGCO_03549	6.92e-183	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Carboxylesterase
MKMBIGCO_03550	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
MKMBIGCO_03551	4.85e-107	smpB	-	-	O	ko:K03664	-	ko00000	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MKMBIGCO_03553	1.2e-71	-	-	-	-	-	-	-	-
MKMBIGCO_03554	6.38e-61	yrdF	-	-	K	ko:K03623	-	ko00000	ribonuclease inhibitor
MKMBIGCO_03555	2.77e-180	yvaG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_03556	3.41e-207	ytlI	-	-	K	ko:K21960	-	ko00000,ko03000	LysR substrate binding domain
MKMBIGCO_03557	1.29e-129	ytmI	-	-	K	ko:K00680	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
MKMBIGCO_03558	2.3e-165	-	-	-	ET	ko:K16956,ko:K16957,ko:K16961	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
MKMBIGCO_03559	7.14e-188	tcyK	-	-	M	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
MKMBIGCO_03560	3.46e-155	ytmL	-	-	P	ko:K16958,ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MKMBIGCO_03561	2.36e-155	-	-	-	U	ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MKMBIGCO_03562	1.49e-179	tcyN	-	-	E	ko:K16960	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1126 ABC-type polar amino acid transport system, ATPase component
MKMBIGCO_03563	3.04e-233	ytmO	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_03564	1.01e-61	ytnI	-	-	O	-	-	-	COG0695 Glutaredoxin and related proteins
MKMBIGCO_03565	0.0	ytnJ	-	-	C	-	-	-	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKMBIGCO_03566	1.43e-153	azoR	-	-	I	ko:K01118	-	ko00000,ko01000	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKMBIGCO_03567	7.9e-246	yvaA	1.1.1.371	-	S	ko:K16044	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
MKMBIGCO_03568	2.81e-64	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	transcriptional
MKMBIGCO_03569	3.24e-40	-	-	-	P	ko:K07213	ko04978,map04978	ko00000,ko00001	Heavy-metal-associated domain
MKMBIGCO_03570	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	P-type ATPase
MKMBIGCO_03571	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	COG2217 Cation transport ATPase
MKMBIGCO_03572	8.75e-136	bdbD	-	-	O	-	-	-	Thioredoxin
MKMBIGCO_03573	3.05e-95	bdbC	-	-	O	ko:K03611	-	ko00000,ko03110	Required for disulfide bond formation in some proteins
MKMBIGCO_03574	1.34e-190	-	-	-	S	-	-	-	Metallo-peptidase family M12
MKMBIGCO_03575	2.48e-127	yvgT	-	-	S	-	-	-	membrane
MKMBIGCO_03576	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
MKMBIGCO_03577	0.0	cysJ	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKMBIGCO_03578	0.0	cysI	1.8.1.2, 1.8.7.1	-	P	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
MKMBIGCO_03579	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	COG0025 NhaP-type Na H and K H antiporters
MKMBIGCO_03580	1.32e-111	yvgO	-	-	-	-	-	-	-
MKMBIGCO_03581	1.77e-200	yvgN	-	-	S	-	-	-	reductase
MKMBIGCO_03582	1.49e-254	sagI	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	COG0842 ABC-type multidrug transport system, permease component
MKMBIGCO_03583	1.36e-246	sagH	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
MKMBIGCO_03584	1.94e-217	sagG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	COG1131 ABC-type multidrug transport system, ATPase component
MKMBIGCO_03585	4.77e-250	-	-	-	T	-	-	-	Histidine kinase
MKMBIGCO_03586	5.32e-147	yfiK	-	-	K	-	-	-	Regulator
MKMBIGCO_03587	5.72e-127	modB	-	-	P	ko:K02018	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG4149 ABC-type molybdate transport system, permease component
MKMBIGCO_03588	1.13e-177	modA	-	-	P	ko:K02020	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0725 ABC-type molybdate transport system, periplasmic component
MKMBIGCO_03589	1.11e-210	yvgK	-	-	P	ko:K07219	-	ko00000	COG1910 Periplasmic molybdate-binding protein domain
MKMBIGCO_03590	0.0	yvgJ	-	-	M	ko:K01138	-	ko00000,ko01000	Belongs to the LTA synthase family
MKMBIGCO_03591	1.01e-110	yvsG	-	-	S	ko:K07038	-	ko00000	LexA-binding, inner membrane-associated putative hydrolase
MKMBIGCO_03592	4.34e-19	-	-	-	S	ko:K06427	-	ko00000	Small spore protein J (Spore_SspJ)
MKMBIGCO_03593	0.0	yvsH	-	-	E	ko:K03294,ko:K03758	-	ko00000,ko02000	Arginine ornithine antiporter
MKMBIGCO_03594	5.06e-159	-	-	-	Q	-	-	-	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MKMBIGCO_03595	2.59e-227	fhuD	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
MKMBIGCO_03596	1.56e-236	fhuB	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_03597	4.58e-224	fhuG	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_03598	1.02e-188	fhuC	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MKMBIGCO_03599	8.03e-87	yvrL	-	-	S	-	-	-	Regulatory protein YrvL
MKMBIGCO_03600	2.1e-293	oxdC	4.1.1.2	-	G	ko:K01569	ko00630,ko01100,map00630,map01100	ko00000,ko00001,ko01000	Oxalate decarboxylase
MKMBIGCO_03601	1.88e-21	-	-	-	S	-	-	-	YvrJ protein family
MKMBIGCO_03602	1.31e-133	yvrI	-	-	K	ko:K03093	-	ko00000,ko03021	RNA polymerase
MKMBIGCO_03603	1.67e-50	-	-	-	-	-	-	-	-
MKMBIGCO_03604	2.7e-172	yvrH	-	-	T	ko:K02483	-	ko00000,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_03605	0.0	yvrG	-	-	T	-	-	-	Histidine kinase
MKMBIGCO_03606	3.11e-218	yvrE	-	-	G	ko:K14274	ko00040,map00040	ko00000,ko00001,ko01000	SMP-30/Gluconolaconase/LRE-like region
MKMBIGCO_03607	7.09e-180	yvrD	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_03608	6.72e-215	yvrC	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
MKMBIGCO_03609	2.55e-227	btuC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKMBIGCO_03610	5.27e-280	yvrA	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components
MKMBIGCO_03611	1.87e-132	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Adenosyltransferase
MKMBIGCO_03612	1.95e-289	yvqJ	-	-	EGP	-	-	-	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_03613	6.33e-66	liaI	-	-	S	ko:K11619	ko02020,map02020	ko00000,ko00001,ko00002	membrane
MKMBIGCO_03614	3.63e-129	liaH	-	-	KT	ko:K03969,ko:K11620	ko02020,map02020	ko00000,ko00001,ko00002	COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
MKMBIGCO_03615	5.11e-186	liaG	-	-	S	ko:K11621	ko02020,map02020	ko00000,ko00001	Putative adhesin
MKMBIGCO_03616	1.27e-163	-	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
MKMBIGCO_03617	3.48e-247	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03618	8.35e-139	vraR	-	-	KT	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_03619	1.07e-262	gerAC	-	-	S	ko:K06290,ko:K06293,ko:K06312	-	ko00000	Spore germination B3/ GerAC like, C-terminal
MKMBIGCO_03620	2.07e-242	gerAB	-	-	E	ko:K06289,ko:K06292	-	ko00000,ko02000	Spore germination protein
MKMBIGCO_03621	0.0	gerAA	-	-	EG	ko:K06288,ko:K06291,ko:K06310	-	ko00000	Spore germination protein
MKMBIGCO_03622	1.83e-33	-	-	-	S	-	-	-	Protein of unknown function (DUF3970)
MKMBIGCO_03623	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
MKMBIGCO_03624	7.31e-200	yuxN	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03625	4.63e-33	-	-	-	-	-	-	-	-
MKMBIGCO_03626	0.0	cssS	2.7.13.3	-	T	ko:K07650	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03627	3.17e-164	cssR	-	-	T	ko:K07770	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
MKMBIGCO_03628	4.4e-304	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKMBIGCO_03629	1.18e-102	dps2	-	-	P	ko:K04047	-	ko00000,ko03036	Belongs to the Dps family
MKMBIGCO_03630	2.91e-192	yusZ	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_03631	0.0	pepF2	-	-	E	-	-	-	COG1164 Oligoendopeptidase F
MKMBIGCO_03632	7.61e-60	-	-	-	S	-	-	-	YusW-like protein
MKMBIGCO_03633	5.24e-192	yusV	3.6.3.34	-	HP	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
MKMBIGCO_03634	2.15e-52	yusU	-	-	S	-	-	-	Protein of unknown function (DUF2573)
MKMBIGCO_03635	6.38e-236	apbA	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKMBIGCO_03636	5.88e-176	-	4.1.1.4	-	Q	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	ko00000,ko00001,ko00002,ko01000	Acetoacetate decarboxylase (ADC)
MKMBIGCO_03637	5.44e-200	-	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03638	0.0	yusP	-	-	P	-	-	-	Major facilitator superfamily
MKMBIGCO_03639	9.65e-92	yusO	-	-	K	-	-	-	Iron dependent repressor, N-terminal DNA binding domain
MKMBIGCO_03640	4.46e-72	yusN	-	-	M	-	-	-	Coat F domain
MKMBIGCO_03641	6.46e-58	-	-	-	-	-	-	-	-
MKMBIGCO_03642	3.46e-211	fadM	-	-	E	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000	Proline dehydrogenase
MKMBIGCO_03643	0.0	fadN	1.1.1.35	-	I	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	ko00000,ko00001,ko00002,ko01000	3-hydroxyacyl-CoA dehydrogenase
MKMBIGCO_03644	7.74e-278	fadA	2.3.1.16	-	I	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	ko00000,ko00001,ko00002,ko01000	Belongs to the thiolase family
MKMBIGCO_03645	0.0	fadE	1.3.8.1	-	I	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	ko00000,ko00001,ko01000	acyl-CoA dehydrogenase
MKMBIGCO_03646	7.13e-84	yusI	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	Belongs to the ArsC family
MKMBIGCO_03647	4.16e-85	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate
MKMBIGCO_03648	3.1e-55	yusG	-	-	S	-	-	-	Protein of unknown function (DUF2553)
MKMBIGCO_03649	2.17e-82	yusF	-	-	L	ko:K07476	-	ko00000	COG1658 Small primase-like proteins (Toprim domain)
MKMBIGCO_03650	1.64e-72	yusE	-	-	CO	-	-	-	Thioredoxin
MKMBIGCO_03651	5.28e-76	yusD	-	-	S	-	-	-	SCP-2 sterol transfer family
MKMBIGCO_03652	3.71e-237	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKMBIGCO_03653	2.08e-138	metI	-	-	P	ko:K02069,ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG2011 ABC-type metal ion transport system, permease component
MKMBIGCO_03654	9e-187	metQ	-	-	P	ko:K02072,ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the NlpA lipoprotein family
MKMBIGCO_03655	2.54e-84	yurZ	-	-	S	-	-	-	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MKMBIGCO_03656	3.82e-183	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
MKMBIGCO_03657	5.01e-311	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	assembly protein SufD
MKMBIGCO_03658	2.31e-298	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKMBIGCO_03659	8.89e-101	nifU	-	-	C	ko:K04488	-	ko00000	COG0822 NifU homolog involved in Fe-S cluster formation
MKMBIGCO_03660	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	FeS cluster assembly
MKMBIGCO_03661	1.25e-201	csn	3.2.1.132	-	M	ko:K01233	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan
MKMBIGCO_03662	1.44e-256	yurR	1.4.5.1	-	E	ko:K00285	ko00360,map00360	ko00000,ko00001,ko01000	COG0665 Glycine D-amino acid oxidases (deaminating)
MKMBIGCO_03663	3.33e-85	yurQ	-	-	L	-	-	-	COG0322 Nuclease subunit of the excinuclease complex
MKMBIGCO_03665	2.73e-211	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MKMBIGCO_03666	2.23e-75	frlB	-	-	M	ko:K10708	-	ko00000,ko01000	Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid
MKMBIGCO_03667	1.28e-313	yurO	-	-	G	ko:K10117	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG1653 ABC-type sugar transport system, periplasmic component
MKMBIGCO_03668	1.51e-202	yurN	-	-	G	ko:K10118	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
MKMBIGCO_03669	8.84e-210	-	-	-	P	ko:K10119	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	COG0395 ABC-type sugar transport system, permease component
MKMBIGCO_03670	1.78e-204	-	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
MKMBIGCO_03671	2.4e-172	frlR1	-	-	K	ko:K03710,ko:K10711	-	ko00000,ko03000	UTRA
MKMBIGCO_03672	7.51e-262	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
MKMBIGCO_03673	5.35e-213	bsn	-	-	L	-	-	-	Ribonuclease
MKMBIGCO_03674	1.9e-296	pucF	3.5.3.9	-	E	ko:K02083	ko00230,ko01120,map00230,map01120	ko00000,ko00001,ko01000,ko01002	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
MKMBIGCO_03675	1.99e-300	pucG	2.6.1.112, 2.6.1.44, 2.6.1.45, 2.6.1.51	-	E	ko:K00830,ko:K00839	ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	ko00000,ko00001,ko00002,ko01000,ko01007	COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase
MKMBIGCO_03676	1.23e-273	blt	-	-	EGP	ko:K08153	-	ko00000,ko00002,ko02000	COG0477 Permeases of the major facilitator superfamily
MKMBIGCO_03680	0.0	pucR	-	-	QT	ko:K09684	-	ko00000,ko03000	COG2508 Regulator of polyketide synthase expression
MKMBIGCO_03681	0.0	allB	3.5.2.5	-	F	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
MKMBIGCO_03682	1.45e-78	-	-	-	S	-	-	-	phosphoglycolate phosphatase activity
MKMBIGCO_03683	6.03e-216	yunF	-	-	S	-	-	-	Protein of unknown function DUF72
MKMBIGCO_03684	4.99e-185	yunE	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
MKMBIGCO_03685	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
MKMBIGCO_03686	7.89e-167	yunB	-	-	S	-	-	-	Sporulation protein YunB (Spo_YunB)
MKMBIGCO_03687	2.36e-250	lytH	-	-	M	ko:K21472	-	ko00000,ko01000,ko01002,ko01011	Peptidase, M23
MKMBIGCO_03688	3.92e-215	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKMBIGCO_03689	3.71e-62	yutD	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_03690	3e-93	yutE	-	-	S	-	-	-	Protein of unknown function DUF86
MKMBIGCO_03691	2.39e-179	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
MKMBIGCO_03692	1.5e-109	yutG	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	COG1267 Phosphatidylglycerophosphatase A and related proteins
MKMBIGCO_03693	4.25e-248	yutH	-	-	S	-	-	-	Spore coat protein
MKMBIGCO_03694	1.43e-308	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
MKMBIGCO_03695	2.3e-251	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKMBIGCO_03696	1.12e-215	thrB	2.7.1.39	-	E	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
MKMBIGCO_03697	0.0	yuxL	3.4.19.1	-	EU	ko:K01303	-	ko00000,ko01000,ko01002	peptidase
MKMBIGCO_03698	1.26e-47	yutI	-	-	O	-	-	-	COG0694 Thioredoxin-like proteins and domains
MKMBIGCO_03699	4.5e-71	yuzD	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_03700	1.71e-265	yutJ	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MKMBIGCO_03701	1.74e-52	yuzB	-	-	S	-	-	-	Belongs to the UPF0349 family
MKMBIGCO_03702	4.26e-273	yutK	-	-	F	ko:K03317	-	ko00000	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKMBIGCO_03703	3.2e-207	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MKMBIGCO_03704	1.38e-82	erpA	-	-	S	ko:K13628	-	ko00000,ko03016	Belongs to the HesB IscA family
MKMBIGCO_03705	4.28e-176	dltE	-	-	M	ko:K14189	-	ko00000,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_03706	3.36e-35	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
MKMBIGCO_03708	2.63e-44	-	-	-	S	-	-	-	Bacteriocin class IId cyclical uberolysin-like
MKMBIGCO_03710	1.08e-155	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
MKMBIGCO_03711	1.63e-90	-	-	-	CP	-	-	-	Membrane
MKMBIGCO_03712	5.68e-40	-	-	-	-	-	-	-	-
MKMBIGCO_03713	4.51e-235	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
MKMBIGCO_03715	1.03e-238	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	reductase
MKMBIGCO_03716	4.16e-301	yumB	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
MKMBIGCO_03717	8.54e-46	yuiB	-	-	S	-	-	-	Putative membrane protein
MKMBIGCO_03718	2.42e-153	yuiC	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_03719	7.09e-101	yuiD	-	-	S	ko:K09775	-	ko00000	protein conserved in bacteria
MKMBIGCO_03720	0.0	pepA	3.4.11.1	-	E	ko:K01255	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MKMBIGCO_03721	9.54e-275	yuiF	-	-	S	ko:K07084	-	ko00000,ko02000	antiporter
MKMBIGCO_03722	8.78e-130	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Biotin biosynthesis protein
MKMBIGCO_03723	4.59e-155	yuiH	-	-	S	-	-	-	Oxidoreductase molybdopterin binding domain
MKMBIGCO_03724	4.05e-208	eSD	-	-	S	ko:K07017	-	ko00000	Putative esterase
MKMBIGCO_03725	6.79e-169	dhbA	1.3.1.28	-	IQ	ko:K00216	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000	Belongs to the short-chain dehydrogenases reductases (SDR) family
MKMBIGCO_03726	2.94e-281	dhbC	5.4.4.2	-	HQ	ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Isochorismate synthase
MKMBIGCO_03727	0.0	entE	2.7.7.58, 6.3.2.14	-	Q	ko:K02363,ko:K04783	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	2,3-dihydroxybenzoate-AMP ligase
MKMBIGCO_03728	1.87e-218	dhbB	3.3.2.1, 6.3.2.14	-	Q	ko:K01252	ko01053,ko01110,ko01130,map01053,map01110,map01130	ko00000,ko00001,ko01000,ko01008	Isochorismatase family
MKMBIGCO_03729	0.0	dhbF	-	-	Q	ko:K04780	ko01053,map01053	ko00000,ko00001,ko01008	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
MKMBIGCO_03730	2.24e-45	mbtH	-	-	S	ko:K05375	ko00261,ko01130,map00261,map01130	ko00000,ko00001,ko00002	MbtH-like protein
MKMBIGCO_03731	1.7e-168	yukJ	-	-	S	-	-	-	Uncharacterized conserved protein (DUF2278)
MKMBIGCO_03732	6.65e-260	ald	1.4.1.1	-	E	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
MKMBIGCO_03733	2.11e-291	yukF	-	-	QT	-	-	-	Transcriptional regulator
MKMBIGCO_03734	5.85e-169	yueD	1.1.1.320	-	IQ	ko:K16216	-	ko00000,ko01000	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
MKMBIGCO_03735	2.23e-124	yueE	-	-	S	ko:K06950	-	ko00000	phosphohydrolase
MKMBIGCO_03736	1.98e-31	-	-	-	S	-	-	-	Protein of unknown function (DUF2642)
MKMBIGCO_03737	1.54e-237	yueF	-	-	S	-	-	-	transporter activity
MKMBIGCO_03738	9e-46	yueG	-	-	S	ko:K06299	-	ko00000	Spore germination protein gerPA/gerPF
MKMBIGCO_03739	5.46e-51	yueH	-	-	S	-	-	-	YueH-like protein
MKMBIGCO_03740	7.94e-90	yueI	-	-	S	-	-	-	Protein of unknown function (DUF1694)
MKMBIGCO_03741	8.02e-135	pncA	-	-	Q	ko:K16788	-	ko00000,ko02000	COG1335 Amidases related to nicotinamidase
MKMBIGCO_03742	0.0	pncB	6.3.4.21	-	H	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MKMBIGCO_03743	6.32e-294	yuxH	-	-	T	-	-	-	signal transduction protein containing EAL and modified HD-GYP domains
MKMBIGCO_03744	1.72e-66	yuzC	-	-	-	-	-	-	-
MKMBIGCO_03746	2.66e-11	-	-	-	S	-	-	-	DegQ (SacQ) family
MKMBIGCO_03747	5.19e-117	comQ	-	-	H	ko:K02251	ko02024,map02024	ko00000,ko00001,ko02044	Polyprenyl synthetase
MKMBIGCO_03749	0.0	comP	2.7.13.3	-	T	ko:K07680	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03750	8.07e-148	comA	-	-	K	ko:K07691	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
MKMBIGCO_03751	9.44e-82	yuxO	-	-	Q	-	-	-	protein, possibly involved in aromatic compounds catabolism
MKMBIGCO_03752	4.2e-79	mrpG	-	-	P	ko:K05571	-	ko00000,ko02000	COG1320 Multisubunit Na H antiporter, MnhG subunit
MKMBIGCO_03753	1.1e-51	mrpF	-	-	P	ko:K05570	-	ko00000,ko02000	Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MKMBIGCO_03754	9.67e-99	mrpE	-	-	P	ko:K05569	-	ko00000,ko02000	Subunit E of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MKMBIGCO_03755	0.0	mrpD	-	-	CP	ko:K05568	-	ko00000,ko02000	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MKMBIGCO_03756	1.47e-67	mrpC	-	-	P	ko:K05567	-	ko00000,ko02000	Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MKMBIGCO_03757	1.27e-89	mrpB	-	-	P	ko:K05566	-	ko00000,ko02000	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali
MKMBIGCO_03758	0.0	mrpA	-	-	CP	ko:K05565	-	ko00000,ko02000	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit
MKMBIGCO_03760	4.39e-218	yufQ	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MKMBIGCO_03761	3.86e-238	yufP	-	-	S	ko:K02057	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
MKMBIGCO_03762	0.0	yufO	3.6.3.17	-	S	ko:K02056	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
MKMBIGCO_03763	2.36e-248	tcsA	-	-	S	ko:K02058,ko:K07335	-	ko00000,ko00002,ko02000	ABC-type transport system, periplasmic component surface lipoprotein
MKMBIGCO_03764	5.63e-163	dcuR	-	-	T	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	COG4565 Response regulator of citrate malate metabolism
MKMBIGCO_03765	0.0	malK	2.7.13.3	-	T	ko:K11614,ko:K11637,ko:K11691	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Signal transduction histidine kinase regulating citrate malate metabolism
MKMBIGCO_03766	1.6e-101	yufK	-	-	S	-	-	-	Family of unknown function (DUF5366)
MKMBIGCO_03767	2.62e-95	yuxK	-	-	S	-	-	-	protein conserved in bacteria
MKMBIGCO_03768	0.0	pbpD	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555,ko:K18770	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin-binding Protein
MKMBIGCO_03769	2.25e-264	yuxJ	-	-	EGP	-	-	-	Major facilitator superfamily
MKMBIGCO_03770	2.64e-153	kapD	-	-	L	ko:K06348	-	ko00000	the KinA pathway to sporulation
MKMBIGCO_03771	3.28e-87	kapB	-	-	G	ko:K06347	ko02020,map02020	ko00000,ko00001	Kinase associated protein B
MKMBIGCO_03772	8.61e-291	kinB2	2.7.13.3	-	T	ko:K07697	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
MKMBIGCO_03773	6.16e-282	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
MKMBIGCO_03774	1.73e-54	yugE	-	-	S	-	-	-	Domain of unknown function (DUF1871)
MKMBIGCO_03775	4.71e-199	yugF	-	-	I	-	-	-	Hydrolase
MKMBIGCO_03776	3.75e-109	alaR	-	-	K	-	-	-	Transcriptional regulator
MKMBIGCO_03777	6.82e-266	yugH	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Aminotransferase
MKMBIGCO_03778	1.43e-82	yugI	-	-	J	ko:K07570,ko:K07571	-	ko00000	RNA binding protein (contains ribosomal protein S1 domain)
MKMBIGCO_03779	3.14e-46	yuzA	-	-	S	ko:K09779	-	ko00000	Domain of unknown function (DUF378)
MKMBIGCO_03780	9.52e-286	yugJ	-	-	C	ko:K19955	-	ko00000,ko01000	oxidoreductases, Fe-dependent alcohol dehydrogenase family
MKMBIGCO_03781	6.49e-290	yugK	-	-	C	ko:K19955	-	ko00000,ko01000	Dehydrogenase
MKMBIGCO_03782	2.51e-151	ycaC	-	-	Q	-	-	-	Isochorismatase family
MKMBIGCO_03783	1.38e-51	-	-	-	S	ko:K19784	-	ko00000	NADPH-dependent FMN reductase
MKMBIGCO_03784	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
MKMBIGCO_03786	1.17e-92	yugN	-	-	S	-	-	-	YugN-like family
MKMBIGCO_03787	2.8e-230	yugO	-	-	P	ko:K10716	-	ko00000,ko02000	COG1226 Kef-type K transport systems
MKMBIGCO_03788	3.47e-35	mstX	-	-	S	-	-	-	Membrane-integrating protein Mistic
MKMBIGCO_03789	3.06e-23	-	-	-	-	-	-	-	-
MKMBIGCO_03790	1.67e-150	yugP	-	-	S	ko:K06973	-	ko00000	Zn-dependent protease
MKMBIGCO_03791	4.67e-296	yugS	-	-	S	-	-	-	COG1253 Hemolysins and related proteins containing CBS domains
MKMBIGCO_03792	0.0	yugT	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	COG0366 Glycosidases
MKMBIGCO_03793	7.42e-96	yugU	-	-	S	-	-	-	Uncharacterised protein family UPF0047
MKMBIGCO_03794	1.41e-242	npd	1.13.12.16	-	S	ko:K00459	ko00910,map00910	ko00000,ko00001,ko01000	COG2070 Dioxygenases related to 2-nitropropane dioxygenase
MKMBIGCO_03795	9.36e-55	-	-	-	-	-	-	-	-
MKMBIGCO_03796	6.36e-179	tgl	2.3.2.13	-	H	ko:K00686	-	ko00000,ko01000	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links
MKMBIGCO_03797	4.4e-316	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MKMBIGCO_03798	0.0	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MKMBIGCO_03799	0.0	mcpA	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MKMBIGCO_03800	0.0	mcpB	-	-	NT	ko:K03406	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko02035	chemotaxis protein
MKMBIGCO_03801	5.71e-126	yraA	3.5.1.124	-	S	ko:K05520	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
MKMBIGCO_03802	2.24e-236	yulF	-	-	S	ko:K22230	ko00562,ko01120,map00562,map01120	ko00000,ko00001,ko01000	Oxidoreductase
MKMBIGCO_03803	4.05e-250	yubA	-	-	S	-	-	-	transporter activity
MKMBIGCO_03804	6.56e-187	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
MKMBIGCO_03808	4.26e-19	-	-	-	-	-	-	-	-
MKMBIGCO_03810	1.43e-175	-	-	-	S	ko:K06366	ko02024,map02024	ko00000,ko00001,ko01000	Aspartate phosphatase response regulator
MKMBIGCO_03814	3.74e-69	yjcN	-	-	-	-	-	-	-
MKMBIGCO_03815	8.44e-154	-	-	-	G	-	-	-	Cupin
MKMBIGCO_03816	2.15e-280	hmp	1.14.12.17, 1.18.1.3	-	C	ko:K05916,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132	ko00000,ko00001,ko00002,ko01000	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKMBIGCO_03817	8.63e-190	-	-	-	NU	-	-	-	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
MKMBIGCO_03818	1.76e-155	ktrA	-	-	P	ko:K03499	-	ko00000,ko02000	COG0569 K transport systems, NAD-binding component
MKMBIGCO_03819	3.37e-121	yuaB	-	-	-	-	-	-	-
MKMBIGCO_03820	1.67e-123	yuaC	-	-	K	ko:K22109	-	ko00000,ko03000	Belongs to the GbsR family
MKMBIGCO_03821	0.0	gbsA	1.2.1.8	-	C	ko:K00130	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
MKMBIGCO_03822	1.74e-290	gbsB	1.1.1.1	-	C	ko:K11440	ko00260,ko01100,map00260,map01100	ko00000,ko00001,ko00002,ko01000	alcohol dehydrogenase
MKMBIGCO_03823	6.79e-141	-	-	-	S	-	-	-	MOSC domain
MKMBIGCO_03824	1.66e-101	yuaE	-	-	S	-	-	-	DinB superfamily
MKMBIGCO_03825	5.61e-109	yuaF	-	-	OU	-	-	-	Membrane protein implicated in regulation of membrane protease activity
MKMBIGCO_03826	3.08e-277	yuaG	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	protein conserved in bacteria
MKMBIGCO_03827	1.99e-124	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter protein (Thia_YuaJ)