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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
HOLOBFIM_00001	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HOLOBFIM_00002	1.02e-260	dnaN	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
HOLOBFIM_00004	4.07e-43	yaaA	-	-	S	ko:K14761	-	ko00000,ko03009	S4 domain protein YaaA
HOLOBFIM_00005	9.09e-260	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HOLOBFIM_00006	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOLOBFIM_00007	0.0	gyrA	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOLOBFIM_00008	5.22e-163	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HOLOBFIM_00009	5.2e-98	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HOLOBFIM_00010	1.12e-64	rpsF	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Binds together with S18 to 16S ribosomal RNA
HOLOBFIM_00011	1.54e-114	ssb	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
HOLOBFIM_00012	3.26e-48	rpsR	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOLOBFIM_00013	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit I
HOLOBFIM_00014	3.29e-228	-	-	-	C	-	-	-	Cytochrome bd terminal oxidase subunit II
HOLOBFIM_00015	1.21e-48	-	-	-	-	-	-	-	-
HOLOBFIM_00016	6.62e-136	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_00018	5.26e-183	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_00021	6.44e-173	p40	-	-	D	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	CHAP domain
HOLOBFIM_00022	0.0	ylbB	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HOLOBFIM_00023	1.76e-165	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00024	1.13e-125	-	-	-	K	-	-	-	transcriptional regulator
HOLOBFIM_00025	4.35e-197	-	-	-	G	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_00026	4.92e-65	-	-	-	-	-	-	-	-
HOLOBFIM_00029	0.0	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HOLOBFIM_00030	1.38e-158	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HOLOBFIM_00031	6.68e-131	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_00033	9.98e-56	-	-	-	-	-	-	-	-
HOLOBFIM_00034	8.19e-212	-	-	-	P	-	-	-	CorA-like Mg2+ transporter protein
HOLOBFIM_00035	3.84e-145	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_00037	2.37e-306	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HOLOBFIM_00039	0.0	pepD	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HOLOBFIM_00040	6.62e-143	-	-	-	S	-	-	-	Membrane
HOLOBFIM_00041	1.14e-128	-	-	-	-	-	-	-	-
HOLOBFIM_00042	7.6e-91	-	-	-	-	-	-	-	-
HOLOBFIM_00043	0.0	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HOLOBFIM_00044	3.4e-24	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HOLOBFIM_00045	3.13e-23	ybfG	-	-	M	-	-	-	peptidoglycan-binding domain-containing protein
HOLOBFIM_00046	7.62e-157	azlC	-	-	E	-	-	-	branched-chain amino acid
HOLOBFIM_00047	7.44e-66	azlD	-	-	S	-	-	-	Branched-chain amino acid transport protein (AzlD)
HOLOBFIM_00049	2.66e-35	-	-	-	-	-	-	-	-
HOLOBFIM_00050	1.85e-147	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_00051	3e-32	-	-	-	-	-	-	-	-
HOLOBFIM_00052	3.5e-13	-	-	-	-	-	-	-	-
HOLOBFIM_00053	1.07e-183	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_00054	6.9e-150	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HOLOBFIM_00055	4.29e-160	kdgR	-	-	K	-	-	-	FCD domain
HOLOBFIM_00057	2.84e-73	ps105	-	-	-	-	-	-	-
HOLOBFIM_00058	1.04e-204	-	-	-	K	-	-	-	Transcriptional activator, Rgg GadR MutR family
HOLOBFIM_00059	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC-type multidrug transport system, ATPase and permease components
HOLOBFIM_00060	1.27e-305	-	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_00061	1.84e-65	-	-	-	K	-	-	-	TRANSCRIPTIONal
HOLOBFIM_00062	0.0	ydgH	-	-	S	ko:K06994	-	ko00000	MMPL family
HOLOBFIM_00063	2.34e-140	-	-	-	K	ko:K22106	-	ko00000,ko03000	Tetracycline repressor, C-terminal all-alpha domain
HOLOBFIM_00065	3.93e-142	opuCD	-	-	P	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_00066	3.55e-222	opuCC	-	-	M	ko:K05845	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HOLOBFIM_00067	2.28e-136	opuCB	-	-	E	ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_00068	9.93e-285	opuCA	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00069	0.000666	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_00071	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	P-type ATPase
HOLOBFIM_00072	3.61e-46	copZ	-	-	P	-	-	-	Heavy-metal-associated domain
HOLOBFIM_00073	1.11e-126	dpsB	-	-	P	-	-	-	Belongs to the Dps family
HOLOBFIM_00074	7.13e-149	flp	-	-	K	ko:K21562	-	ko00000,ko03000	helix_turn_helix, cAMP Regulatory protein
HOLOBFIM_00075	4.62e-181	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
HOLOBFIM_00076	1.01e-292	trpB	4.2.1.20, 5.3.1.24	-	E	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HOLOBFIM_00077	1.07e-131	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpF family
HOLOBFIM_00078	7.66e-178	trpC	4.1.1.48, 5.3.1.24	-	E	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TrpC family
HOLOBFIM_00079	3.97e-232	trpD	2.4.2.18, 4.1.3.27	-	F	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOLOBFIM_00080	1.11e-262	-	-	-	-	-	-	-	-
HOLOBFIM_00081	0.0	-	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_00082	1.48e-139	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_00084	7.29e-157	-	-	-	-	-	-	-	-
HOLOBFIM_00087	1.82e-178	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
HOLOBFIM_00088	2.45e-215	dapA	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOLOBFIM_00089	1.06e-280	hipO	3.5.1.47	-	E	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate
HOLOBFIM_00090	4.4e-116	dapH	2.3.1.117, 2.3.1.89	-	E	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate
HOLOBFIM_00091	0.0	lysA	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
HOLOBFIM_00092	0.0	lysC	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HOLOBFIM_00093	5.96e-240	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HOLOBFIM_00094	9.26e-248	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOLOBFIM_00095	8.13e-82	-	-	-	-	-	-	-	-
HOLOBFIM_00096	1.35e-97	-	-	-	L	-	-	-	NUDIX domain
HOLOBFIM_00097	5.52e-185	-	-	-	EG	-	-	-	EamA-like transporter family
HOLOBFIM_00098	3.87e-115	-	-	-	S	-	-	-	Phospholipase A2
HOLOBFIM_00100	0.0	yybT	-	-	T	-	-	-	signaling protein consisting of a modified GGDEF domain and a DHH domain
HOLOBFIM_00101	1.35e-97	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HOLOBFIM_00102	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_00103	0.0	dnaB	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	Participates in initiation and elongation during chromosome replication
HOLOBFIM_00104	7.71e-276	-	-	-	-	-	-	-	-
HOLOBFIM_00105	0.0	pts32BC	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_00106	1.01e-165	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HOLOBFIM_00107	1.65e-152	yleF	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HOLOBFIM_00108	9.64e-317	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOLOBFIM_00109	0.0	cadA	3.6.3.3, 3.6.3.5	-	P	ko:K01534	-	ko00000,ko01000	P-type ATPase
HOLOBFIM_00110	4.34e-75	cadC5	-	-	K	ko:K21903	-	ko00000,ko03000	helix_turn_helix, Arsenical Resistance Operon Repressor
HOLOBFIM_00111	0.0	-	3.6.3.6	-	P	ko:K01535	ko00190,map00190	ko00000,ko00001,ko01000	Cation transporter/ATPase, N-terminus
HOLOBFIM_00112	7.26e-208	lysR5	-	-	K	-	-	-	LysR substrate binding domain
HOLOBFIM_00113	1.69e-256	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_00114	1.91e-46	-	-	-	S	-	-	-	Phospholipase_D-nuclease N-terminal
HOLOBFIM_00115	2.26e-215	yxlF	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_00116	6.26e-169	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
HOLOBFIM_00117	0.0	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Ribonucleoside-triphosphate reductase
HOLOBFIM_00119	1.1e-130	-	-	-	K	-	-	-	Bacteriophage CI repressor helix-turn-helix domain
HOLOBFIM_00120	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_00121	1.5e-181	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
HOLOBFIM_00122	0.0	yvdP	-	-	C	-	-	-	COG0277 FAD FMN-containing dehydrogenases
HOLOBFIM_00123	3.06e-16	-	-	-	-	-	-	-	-
HOLOBFIM_00124	4.62e-12	-	-	-	-	-	-	-	-
HOLOBFIM_00125	2.66e-57	-	-	-	S	-	-	-	Protein of unknown function (DUF2089)
HOLOBFIM_00126	1.57e-235	yveB	-	-	I	-	-	-	PAP2 superfamily
HOLOBFIM_00127	2.25e-267	mccF	-	-	V	-	-	-	LD-carboxypeptidase
HOLOBFIM_00128	6.55e-57	-	-	-	-	-	-	-	-
HOLOBFIM_00129	2.61e-261	ddl	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
HOLOBFIM_00130	3.37e-115	adaB	2.1.1.63	-	L	ko:K00567,ko:K10778,ko:K13531	-	ko00000,ko01000,ko03000,ko03400	Methyltransferase
HOLOBFIM_00131	1.17e-245	ldhD3	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOLOBFIM_00132	6.75e-57	-	-	-	-	-	-	-	-
HOLOBFIM_00133	6.94e-106	-	-	-	K	-	-	-	Transcriptional regulator
HOLOBFIM_00134	5.79e-207	-	1.6.5.5	-	C	ko:K00344	-	ko00000,ko01000	alcohol dehydrogenase
HOLOBFIM_00135	3.79e-71	-	-	-	S	ko:K08987	-	ko00000	Protein of unknown function (DUF1304)
HOLOBFIM_00136	1.7e-72	-	-	-	S	-	-	-	Protein of unknown function (DUF1516)
HOLOBFIM_00137	0.0	XK27_07275	-	-	S	ko:K06901	-	ko00000,ko02000	permease
HOLOBFIM_00138	1.2e-61	-	-	-	S	ko:K09004	-	ko00000	DsrE/DsrF-like family
HOLOBFIM_00139	2.04e-228	mhqA	-	-	E	ko:K15975	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HOLOBFIM_00140	2.32e-39	-	-	-	-	-	-	-	-
HOLOBFIM_00141	1.04e-134	yoaA	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOLOBFIM_00142	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_00144	2.34e-166	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_00145	2.04e-171	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_00146	2.43e-242	ynjC	-	-	S	-	-	-	Cell surface protein
HOLOBFIM_00148	0.0	-	-	-	L	-	-	-	Mga helix-turn-helix domain
HOLOBFIM_00149	3.74e-219	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
HOLOBFIM_00150	1.1e-76	-	-	-	-	-	-	-	-
HOLOBFIM_00151	0.0	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HOLOBFIM_00152	1.07e-282	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOLOBFIM_00153	2.74e-203	pphA	3.1.3.16	-	T	ko:K07313	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HOLOBFIM_00154	6.39e-177	-	-	-	L	ko:K07457	-	ko00000	Base excision DNA repair protein, HhH-GPD family
HOLOBFIM_00155	4.22e-60	-	-	-	S	-	-	-	Thiamine-binding protein
HOLOBFIM_00156	0.0	yhgE	-	-	V	ko:K01421	-	ko00000	domain protein
HOLOBFIM_00157	9.63e-130	yobS	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_00158	0.0	bmr3	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_00160	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HOLOBFIM_00161	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HOLOBFIM_00162	1.16e-130	-	-	-	-	-	-	-	-
HOLOBFIM_00163	3.66e-67	-	-	-	-	-	-	-	-
HOLOBFIM_00164	8.34e-93	-	-	-	-	-	-	-	-
HOLOBFIM_00165	4.91e-115	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_00166	1.91e-56	-	-	-	-	-	-	-	-
HOLOBFIM_00167	1.39e-101	-	-	-	S	-	-	-	NUDIX domain
HOLOBFIM_00168	8.98e-275	-	-	-	S	-	-	-	nuclear-transcribed mRNA catabolic process, no-go decay
HOLOBFIM_00169	1.94e-284	-	-	-	V	-	-	-	ABC transporter transmembrane region
HOLOBFIM_00170	1.78e-141	ywdE	-	-	K	ko:K20375	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
HOLOBFIM_00171	0.0	fnq20	-	-	S	-	-	-	FAD-NAD(P)-binding
HOLOBFIM_00172	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
HOLOBFIM_00173	6.18e-150	-	-	-	-	-	-	-	-
HOLOBFIM_00174	2.55e-288	-	-	-	S	ko:K06872	-	ko00000	TPM domain
HOLOBFIM_00175	3.56e-177	yunE	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
HOLOBFIM_00176	6.45e-74	ywjH	-	-	S	-	-	-	Protein of unknown function (DUF1634)
HOLOBFIM_00177	1.47e-07	-	-	-	-	-	-	-	-
HOLOBFIM_00178	1.47e-116	-	-	-	-	-	-	-	-
HOLOBFIM_00179	4.85e-65	-	-	-	-	-	-	-	-
HOLOBFIM_00180	1.63e-109	-	-	-	C	-	-	-	Flavodoxin
HOLOBFIM_00181	5.54e-50	-	-	-	-	-	-	-	-
HOLOBFIM_00182	2.82e-36	-	-	-	-	-	-	-	-
HOLOBFIM_00183	2.86e-219	-	1.1.1.26	-	CH	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOLOBFIM_00184	2.27e-94	-	-	-	S	ko:K07006	-	ko00000	Pyridoxamine 5'-phosphate oxidase
HOLOBFIM_00185	4.95e-53	-	-	-	S	-	-	-	Transglycosylase associated protein
HOLOBFIM_00186	1.16e-112	-	-	-	S	-	-	-	Protein conserved in bacteria
HOLOBFIM_00187	4.15e-34	-	-	-	-	-	-	-	-
HOLOBFIM_00188	8.12e-90	asp23	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HOLOBFIM_00189	1.97e-92	asp2	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HOLOBFIM_00190	2.66e-147	-	-	-	S	-	-	-	Protein of unknown function (DUF969)
HOLOBFIM_00191	1.42e-195	-	-	-	S	-	-	-	Protein of unknown function (DUF979)
HOLOBFIM_00192	6.93e-154	pcp	3.4.19.3	-	O	ko:K01304	-	ko00000,ko01000,ko01002	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HOLOBFIM_00193	1.02e-137	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
HOLOBFIM_00194	1.35e-164	cobQ	-	-	S	ko:K07009	-	ko00000	glutamine amidotransferase
HOLOBFIM_00195	4.01e-87	-	-	-	-	-	-	-	-
HOLOBFIM_00196	2.27e-167	rsmG	2.1.1.170	-	J	ko:K03501	-	ko00000,ko01000,ko03009,ko03036	Specifically methylates the N7 position of a guanine in 16S rRNA
HOLOBFIM_00197	3.25e-187	noc	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HOLOBFIM_00198	1.49e-177	soj	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	Sporulation initiation inhibitor
HOLOBFIM_00199	1.11e-201	spo0J	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	Belongs to the ParB family
HOLOBFIM_00200	3.26e-40	yyzM	-	-	S	-	-	-	Bacterial protein of unknown function (DUF951)
HOLOBFIM_00201	9.76e-237	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
HOLOBFIM_00202	7.12e-169	-	-	-	S	-	-	-	Protein of unknown function (DUF1129)
HOLOBFIM_00203	0.0	guaB	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HOLOBFIM_00204	1.14e-153	-	-	-	-	-	-	-	-
HOLOBFIM_00205	1.68e-156	vanR	-	-	K	-	-	-	response regulator
HOLOBFIM_00206	2.81e-278	hpk31	-	-	T	-	-	-	Histidine kinase
HOLOBFIM_00207	2.75e-303	dacA	3.4.16.4	-	M	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	Belongs to the peptidase S11 family
HOLOBFIM_00208	1.02e-103	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HOLOBFIM_00209	0.0	murE	6.3.2.13, 6.3.2.7	-	M	ko:K01928,ko:K05362	ko00300,ko00550,ko01100,map00300,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HOLOBFIM_00210	3.16e-181	racD	5.1.1.13	-	G	ko:K01779	ko00250,ko01054,map00250,map01054	ko00000,ko00001,ko01000	Belongs to the aspartate glutamate racemases family
HOLOBFIM_00211	1.36e-209	yvgN	-	-	C	-	-	-	Aldo keto reductase
HOLOBFIM_00212	1.27e-186	gntR	-	-	K	-	-	-	rpiR family
HOLOBFIM_00213	2.98e-216	gntZ	1.1.1.343, 1.1.1.44	-	G	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Dehydrogenase
HOLOBFIM_00214	0.0	gntK	2.7.1.12	-	G	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko01000	Belongs to the FGGY kinase family
HOLOBFIM_00215	6.55e-270	gntP	-	-	EG	ko:K03299	-	ko00000,ko02000	Gluconate
HOLOBFIM_00216	3.74e-75	-	-	-	-	-	-	-	-
HOLOBFIM_00217	5.86e-167	adcC	-	-	P	ko:K02074,ko:K09817,ko:K11710	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HOLOBFIM_00218	9.9e-172	znuB	-	-	U	ko:K02075,ko:K09816	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
HOLOBFIM_00219	1.42e-209	prpA3	3.1.3.16	-	T	ko:K01090	-	ko00000,ko01000	Calcineurin-like phosphoesterase superfamily domain
HOLOBFIM_00220	3.73e-206	glxR	1.1.1.31	-	I	ko:K00020	ko00280,ko01100,map00280,map01100	ko00000,ko00001,ko01000	Dehydrogenase
HOLOBFIM_00221	0.0	pepF	-	-	E	ko:K08602	-	ko00000,ko01000,ko01002	oligoendopeptidase F
HOLOBFIM_00222	1.39e-239	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HOLOBFIM_00223	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HOLOBFIM_00224	3.46e-103	-	-	-	T	-	-	-	Sh3 type 3 domain protein
HOLOBFIM_00225	7.68e-174	glcR	-	-	K	ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
HOLOBFIM_00226	9.44e-188	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HOLOBFIM_00227	1.8e-173	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
HOLOBFIM_00228	4.42e-54	-	-	-	-	-	-	-	-
HOLOBFIM_00229	8.49e-138	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
HOLOBFIM_00230	2.78e-222	draG	-	-	O	-	-	-	ADP-ribosylglycohydrolase
HOLOBFIM_00231	0.0	-	-	-	S	-	-	-	ABC transporter
HOLOBFIM_00232	1.69e-174	ypaC	-	-	Q	-	-	-	Methyltransferase domain
HOLOBFIM_00233	1.45e-46	-	-	-	-	-	-	-	-
HOLOBFIM_00234	5.19e-90	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HOLOBFIM_00236	4.3e-71	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HOLOBFIM_00237	2.56e-175	-	-	-	S	-	-	-	Putative threonine/serine exporter
HOLOBFIM_00238	2.51e-98	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HOLOBFIM_00239	3.96e-274	livJ	-	-	E	ko:K01999	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Receptor family ligand binding region
HOLOBFIM_00240	1.04e-191	livH	-	-	U	ko:K01997	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
HOLOBFIM_00241	1.1e-182	livM	-	-	E	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid transport system / permease component
HOLOBFIM_00242	7.09e-179	livG	-	-	E	ko:K01995	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Branched-chain amino acid ATP-binding cassette transporter
HOLOBFIM_00243	1.16e-159	livF	-	-	E	ko:K01996	ko02010,ko02024,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_00244	6.23e-213	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HOLOBFIM_00245	4.56e-303	pts14C	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_00246	4.1e-152	-	-	-	G	-	-	-	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HOLOBFIM_00247	1.01e-149	deoC	4.1.2.4	-	F	ko:K01619	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HOLOBFIM_00248	3.24e-293	deoB	5.4.2.7	-	G	ko:K01839	ko00030,ko00230,map00030,map00230	ko00000,ko00001,ko01000	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HOLOBFIM_00249	3.82e-167	deoD	2.4.2.1	-	F	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Purine nucleoside phosphorylase
HOLOBFIM_00250	1.58e-210	p75	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC P60 family protein
HOLOBFIM_00253	0.0	nox	1.6.3.4	-	C	ko:K17869	-	ko00000,ko01000	NADH oxidase
HOLOBFIM_00254	1.85e-205	-	-	-	-	-	-	-	-
HOLOBFIM_00255	6.85e-155	-	-	-	-	-	-	-	-
HOLOBFIM_00256	0.0	uvrB3	3.1.12.1	-	KL	ko:K07464	-	ko00000,ko01000,ko02048	DEAD_2
HOLOBFIM_00257	3.49e-307	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HOLOBFIM_00258	5.21e-109	-	-	-	-	-	-	-	-
HOLOBFIM_00259	0.0	strH	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Gram-positive signal peptide protein, YSIRK family
HOLOBFIM_00260	9.12e-249	manA	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	mannose-6-phosphate isomerase
HOLOBFIM_00261	5.43e-167	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HOLOBFIM_00262	1.63e-280	agaS	-	-	G	ko:K02082	-	ko00000,ko01000	SIS domain
HOLOBFIM_00263	2.26e-288	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HOLOBFIM_00264	0.0	bgaC	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
HOLOBFIM_00265	5.61e-108	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00266	4.68e-206	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00267	3.66e-187	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_00268	2.72e-85	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00269	2.09e-177	lacC	2.7.1.144	-	F	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HOLOBFIM_00270	3.51e-182	srlD	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	KR domain
HOLOBFIM_00271	4.19e-300	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_00273	2.36e-86	-	2.7.1.200, 2.7.1.204	-	G	ko:K02773,ko:K20112	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00274	1.58e-60	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00275	1.65e-179	-	-	-	-	-	-	-	-
HOLOBFIM_00276	3.76e-287	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2325)
HOLOBFIM_00277	9.16e-244	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
HOLOBFIM_00278	1.55e-251	-	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HOLOBFIM_00279	0.0	-	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_00280	2.96e-78	-	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00281	1.18e-67	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HOLOBFIM_00282	4.94e-241	-	-	-	E	-	-	-	M42 glutamyl aminopeptidase
HOLOBFIM_00283	0.0	-	-	-	GKT	ko:K03491	-	ko00000,ko03000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00284	2.02e-308	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
HOLOBFIM_00285	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HOLOBFIM_00286	1.2e-153	-	-	-	S	ko:K03824	-	ko00000,ko01000	Acetyltransferase (GNAT) family
HOLOBFIM_00288	4.57e-123	-	-	-	S	ko:K16925	-	ko00000,ko00002,ko02000	ABC-type cobalt transport system, permease component
HOLOBFIM_00289	2.12e-308	-	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HOLOBFIM_00290	1.17e-136	ykoC	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
HOLOBFIM_00291	1.39e-165	tenA	3.5.99.2	-	K	ko:K03707	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03000	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HOLOBFIM_00292	5.72e-104	thiW	-	-	S	-	-	-	Thiamine-precursor transporter protein (ThiW)
HOLOBFIM_00293	1.01e-192	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HOLOBFIM_00294	6.07e-138	thiE	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
HOLOBFIM_00295	7.39e-188	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HOLOBFIM_00296	0.0	-	-	-	E	-	-	-	Amino acid permease
HOLOBFIM_00297	1.36e-44	-	-	-	-	-	-	-	-
HOLOBFIM_00298	4.9e-239	rbsR	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HOLOBFIM_00299	3.13e-86	rbsD	5.4.99.62	-	G	ko:K06726	ko02010,map02010	ko00000,ko00001,ko01000	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
HOLOBFIM_00300	0.0	rbsA	3.6.3.17	-	G	ko:K10441	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HOLOBFIM_00301	4.84e-198	rbsC	-	-	U	ko:K10440	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HOLOBFIM_00302	2.84e-214	rbsB	-	-	G	ko:K10439	ko02010,ko02030,map02010,map02030	ko00000,ko00001,ko00002,ko02000	Periplasmic binding protein domain
HOLOBFIM_00303	1.1e-206	rbsK	2.7.1.15	-	H	ko:K00852	ko00030,map00030	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOLOBFIM_00304	0.0	pbpC	-	-	M	ko:K21467	-	ko00000,ko01011	NTF2-like N-terminal transpeptidase domain
HOLOBFIM_00305	1.63e-298	-	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_00306	6.3e-95	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
HOLOBFIM_00307	8.73e-131	-	-	-	-	-	-	-	-
HOLOBFIM_00308	9.68e-29	-	-	-	-	-	-	-	-
HOLOBFIM_00309	2.25e-82	-	-	-	-	-	-	-	-
HOLOBFIM_00310	1.14e-79	-	-	-	-	-	-	-	-
HOLOBFIM_00311	0.0	frdC	1.3.5.1, 1.3.5.4	-	C	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	ko00000,ko00001,ko00002,ko01000	HI0933-like protein
HOLOBFIM_00312	1.64e-250	-	-	-	GKT	-	-	-	transcriptional antiterminator
HOLOBFIM_00313	4.1e-67	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00314	5.62e-292	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_00315	5.04e-90	-	-	-	-	-	-	-	-
HOLOBFIM_00316	6.47e-208	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_00317	2.61e-148	-	-	-	S	-	-	-	Zeta toxin
HOLOBFIM_00318	3.2e-203	-	-	-	K	-	-	-	Sugar-specific transcriptional regulator TrmB
HOLOBFIM_00319	9.64e-191	-	-	-	S	-	-	-	Sulfite exporter TauE/SafE
HOLOBFIM_00320	1.18e-228	-	4.3.1.12	-	E	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	ko00000,ko00001,ko01000	Ornithine cyclodeaminase/mu-crystallin family
HOLOBFIM_00321	9.1e-190	-	3.1.1.24	-	S	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Alpha/beta hydrolase family
HOLOBFIM_00323	6.22e-286	-	-	-	M	-	-	-	Domain of unknown function (DUF5011)
HOLOBFIM_00324	9.65e-91	-	-	-	S	ko:K07006	-	ko00000	Pyridoxamine 5'-phosphate oxidase
HOLOBFIM_00325	5.11e-93	yqeB	-	-	S	-	-	-	Pyrimidine dimer DNA glycosylase
HOLOBFIM_00326	1.23e-193	bla1	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase
HOLOBFIM_00327	2.12e-108	-	-	-	-	-	-	-	-
HOLOBFIM_00328	7.42e-230	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HOLOBFIM_00329	1.22e-181	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00330	4.97e-166	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_00331	4.69e-284	-	-	-	P	-	-	-	Type I phosphodiesterase / nucleotide pyrophosphatase
HOLOBFIM_00332	2.47e-214	pkn1	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
HOLOBFIM_00333	2.44e-169	-	-	-	S	ko:K07090	-	ko00000	Sulfite exporter TauE/SafE
HOLOBFIM_00334	2.25e-236	ydeM3	-	-	C	ko:K06871	-	ko00000	Iron-sulfur cluster-binding domain
HOLOBFIM_00335	8.52e-203	estA	-	CE1	S	ko:K03930	-	ko00000,ko01000	Putative esterase
HOLOBFIM_00336	1.23e-193	-	-	-	G	ko:K02796,ko:K17467	ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HOLOBFIM_00337	2.28e-172	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00338	1.12e-116	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00339	8.5e-91	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00340	0.0	-	-	-	K	ko:K19505	-	ko00000,ko03000	Sigma-54 interaction domain
HOLOBFIM_00341	3.69e-301	rpoN	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	Sigma-54 factor, core binding domain
HOLOBFIM_00342	0.0	-	-	-	K	ko:K02538	-	ko00000,ko03000	PRD domain
HOLOBFIM_00343	9.03e-103	ptsN	2.7.1.194, 2.7.1.200, 2.7.1.202, 2.7.1.204	-	G	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K03491,ko:K11201,ko:K20112	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOLOBFIM_00344	7.37e-223	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_00345	8.68e-106	-	2.7.1.202	-	G	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00346	1.08e-63	-	2.7.1.202	-	G	ko:K02769	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00347	1.42e-219	-	-	-	G	ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	Phosphotransferase System
HOLOBFIM_00348	1.44e-230	-	-	-	G	-	-	-	Domain of unknown function (DUF4432)
HOLOBFIM_00349	1.15e-172	-	5.3.1.15	-	S	ko:K09988	ko00040,map00040	ko00000,ko00001,ko01000	Pfam:DUF1498
HOLOBFIM_00350	0.0	xylB	2.7.1.17, 2.7.1.53	-	G	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the FGGY kinase family
HOLOBFIM_00351	1.21e-98	-	-	-	G	ko:K11201	-	ko00000,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00352	0.0	pts31BC	-	-	G	ko:K11202,ko:K11203	-	ko00000,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00353	2.7e-291	malY	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
HOLOBFIM_00354	0.0	-	-	-	G	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00355	0.0	-	-	-	K	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00356	4.92e-203	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_00357	0.0	-	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_00358	1.5e-187	-	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	Enoyl-(Acyl carrier protein) reductase
HOLOBFIM_00359	5.33e-98	-	2.7.1.191, 2.7.1.203	-	G	ko:K02793,ko:K17464	ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00360	4.91e-110	-	2.7.1.203	-	G	ko:K17465	ko00030,ko01120,ko02060,map00030,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00361	5.6e-170	-	-	-	G	ko:K17466	ko00030,ko01120,ko02060,map00030,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00362	5.44e-198	-	-	-	G	ko:K02796,ko:K17467	ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HOLOBFIM_00363	1.83e-279	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
HOLOBFIM_00364	3.51e-145	dhaL	2.7.1.121, 2.7.1.28, 2.7.1.29, 4.6.1.15	-	S	ko:K00863,ko:K05879	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	ko00000,ko00001,ko00002,ko01000	Dak2
HOLOBFIM_00365	7.21e-237	-	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
HOLOBFIM_00366	5.39e-152	hxlA	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
HOLOBFIM_00367	5.82e-130	hxlB	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	sugar phosphate isomerase involved in capsule formation
HOLOBFIM_00368	5.41e-171	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HOLOBFIM_00369	4.08e-311	-	-	-	E	ko:K19956	ko00051,map00051	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
HOLOBFIM_00370	3.25e-224	-	-	-	K	-	-	-	sugar-binding domain protein
HOLOBFIM_00371	5.02e-186	srlD2	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	NAD dependent epimerase/dehydratase family
HOLOBFIM_00372	1.24e-89	-	2.7.1.206	-	G	ko:K02812	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00373	4.08e-112	-	2.7.1.206	-	G	ko:K02813	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00374	3.93e-184	-	-	-	U	ko:K02746,ko:K02795,ko:K02814	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00375	8.69e-195	manZ	-	-	G	ko:K02796,ko:K02815	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HOLOBFIM_00376	3.33e-211	kbaY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_00377	0.0	sdcS	-	-	P	ko:K14445	-	ko00000,ko02000	transporter
HOLOBFIM_00378	3.72e-300	-	-	-	C	-	-	-	FAD dependent oxidoreductase
HOLOBFIM_00379	8.42e-204	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
HOLOBFIM_00380	4.54e-205	XK27_10120	-	-	K	-	-	-	S-adenosyl-l-methionine hydroxide adenosyltransferase
HOLOBFIM_00381	1.05e-127	-	-	-	S	ko:K16924	-	ko00000,ko00002,ko02000	UPF0397 protein
HOLOBFIM_00382	0.0	ykoD	-	-	P	ko:K16786,ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00383	1.62e-191	cbiQ	-	-	P	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt transport
HOLOBFIM_00384	1.71e-246	menC	4.2.1.113	-	H	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
HOLOBFIM_00385	1.5e-263	-	-	-	G	-	-	-	Major Facilitator Superfamily
HOLOBFIM_00386	1.87e-256	-	-	-	E	-	-	-	Peptidase family M20/M25/M40
HOLOBFIM_00387	2.79e-126	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
HOLOBFIM_00388	0.0	ebgA	3.2.1.23	-	G	ko:K01190,ko:K12111	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
HOLOBFIM_00389	0.0	-	-	-	E	-	-	-	Amino Acid
HOLOBFIM_00390	3.06e-304	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
HOLOBFIM_00391	1.07e-181	-	-	-	K	-	-	-	helix_turn_helix, arabinose operon control protein
HOLOBFIM_00392	1.88e-63	-	-	-	-	-	-	-	-
HOLOBFIM_00393	0.0	-	-	-	K	-	-	-	Sigma-54 interaction domain
HOLOBFIM_00394	6.79e-95	-	-	-	G	ko:K02744	ko00052,ko02060,map00052,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00395	2.66e-117	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00396	5.53e-196	levC	-	-	M	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00397	2.15e-199	levD	-	-	G	ko:K02771	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_00398	9.35e-74	-	-	-	-	-	-	-	-
HOLOBFIM_00399	0.0	-	3.2.1.65	GH32	G	ko:K01212	ko00500,map00500	ko00000,ko00001,ko01000	Glycosyl hydrolases family 32
HOLOBFIM_00401	6.93e-161	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HOLOBFIM_00402	4.79e-173	-	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
HOLOBFIM_00403	5.04e-147	-	4.1.2.43	-	G	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
HOLOBFIM_00404	4.73e-125	-	5.3.1.27	-	M	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	SIS domain
HOLOBFIM_00405	0.0	-	2.7.1.197	-	G	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00406	1.81e-273	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
HOLOBFIM_00407	7.03e-246	-	1.5.1.28	-	C	ko:K04940	-	ko00000,ko01000	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
HOLOBFIM_00408	1.18e-171	yxeO	-	-	E	ko:K16960,ko:K16963	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter
HOLOBFIM_00409	1.15e-204	-	-	-	ET	ko:K16957	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
HOLOBFIM_00410	1.74e-146	ytmL	-	-	P	ko:K16958,ko:K16959	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_00411	6.03e-150	-	-	-	P	ko:K16958	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_00412	4.55e-304	proP	-	-	EGP	ko:K03761,ko:K03762	-	ko00000,ko02000	Sugar (and other) transporter
HOLOBFIM_00414	1.33e-17	-	-	-	S	-	-	-	YvrJ protein family
HOLOBFIM_00415	3.19e-182	-	-	-	M	-	-	-	hydrolase, family 25
HOLOBFIM_00416	1.68e-170	ypiA	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HOLOBFIM_00417	2.63e-86	-	-	-	C	-	-	-	Flavodoxin
HOLOBFIM_00418	6.61e-19	-	-	-	C	-	-	-	Flavodoxin
HOLOBFIM_00419	1.26e-112	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_00420	5.44e-236	yxeA	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter permease
HOLOBFIM_00421	8.27e-153	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00422	0.0	npr	1.11.1.1	-	C	ko:K05910	-	ko00000,ko01000	NADH oxidase
HOLOBFIM_00423	7.51e-194	-	-	-	S	-	-	-	hydrolase
HOLOBFIM_00424	1.49e-58	-	-	-	S	ko:K19157	-	ko00000,ko01000,ko02048	Bacterial toxin of type II toxin-antitoxin system, YafQ
HOLOBFIM_00425	6.67e-237	-	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HOLOBFIM_00426	1.48e-109	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_00427	2.18e-177	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_00428	7.9e-196	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_00429	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
HOLOBFIM_00430	8.75e-90	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00431	0.0	malL	3.2.1.10	GH13	G	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HOLOBFIM_00432	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HOLOBFIM_00433	0.0	-	-	-	V	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HOLOBFIM_00435	0.0	pip	-	-	V	ko:K01421	-	ko00000	domain protein
HOLOBFIM_00436	0.0	-	-	-	GK	-	-	-	helix_turn_helix, arabinose operon control protein
HOLOBFIM_00437	2.26e-242	-	-	-	G	-	-	-	Major Facilitator Superfamily
HOLOBFIM_00438	0.0	-	-	-	S	ko:K12941	-	ko00000,ko01002	Peptidase dimerisation domain
HOLOBFIM_00439	1.83e-199	metQ1	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HOLOBFIM_00440	5.84e-253	-	3.5.1.24	-	M	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	ko00000,ko00001,ko01000	Linear amide C-N hydrolases, choloylglycine hydrolase family
HOLOBFIM_00441	1.75e-105	-	-	-	-	-	-	-	-
HOLOBFIM_00442	0.0	l1n	4.2.1.53	-	S	ko:K10254	-	ko00000,ko01000	Myosin-crossreactive antigen
HOLOBFIM_00443	7.24e-23	-	-	-	-	-	-	-	-
HOLOBFIM_00444	2.03e-130	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_00445	2.1e-78	dhaM	2.7.1.121	-	S	ko:K05881	ko00561,map00561	ko00000,ko00001,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_00446	6.75e-132	dhaL	2.7.1.121	-	S	ko:K05879	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak2
HOLOBFIM_00447	1.03e-242	dhaK	2.7.1.121	-	G	ko:K05878	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Dak1 domain
HOLOBFIM_00448	5.87e-99	-	-	-	O	-	-	-	OsmC-like protein
HOLOBFIM_00449	0.0	-	-	-	L	-	-	-	Exonuclease
HOLOBFIM_00450	3.49e-63	yczG	-	-	K	-	-	-	Helix-turn-helix domain
HOLOBFIM_00451	1.28e-258	yceJ	-	-	EGP	ko:K08221	-	ko00000,ko02000	transporter
HOLOBFIM_00452	4.89e-139	ydfF	-	-	K	-	-	-	Transcriptional
HOLOBFIM_00453	2.77e-139	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HOLOBFIM_00454	5.36e-215	fba	4.1.2.13, 4.1.2.29	-	G	ko:K01624,ko:K03339	ko00010,ko00030,ko00051,ko00562,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-1,6-bisphosphate aldolase, class II
HOLOBFIM_00455	0.0	cidC	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HOLOBFIM_00456	5.8e-248	pbpE	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_00457	3.81e-191	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HOLOBFIM_00458	3.17e-185	-	-	-	H	-	-	-	Protein of unknown function (DUF1698)
HOLOBFIM_00459	4.68e-183	puuD	-	-	S	ko:K07010	-	ko00000,ko01002	peptidase C26
HOLOBFIM_00460	0.0	-	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	Glutamine synthetase, catalytic domain
HOLOBFIM_00461	4.16e-283	-	-	-	S	ko:K07045	-	ko00000	Amidohydrolase
HOLOBFIM_00462	0.0	-	-	-	E	-	-	-	Amino acid permease
HOLOBFIM_00463	9.74e-98	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HOLOBFIM_00464	9.19e-209	-	-	-	S	-	-	-	reductase
HOLOBFIM_00465	0.0	-	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HOLOBFIM_00466	6.23e-133	tnpR1	-	-	L	-	-	-	Resolvase, N terminal domain
HOLOBFIM_00467	0.0	yvcC	-	-	M	-	-	-	Cna protein B-type domain
HOLOBFIM_00468	4.1e-162	-	-	-	M	-	-	-	domain protein
HOLOBFIM_00469	1.25e-236	-	-	-	M	-	-	-	LPXTG cell wall anchor motif
HOLOBFIM_00470	9.06e-258	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HOLOBFIM_00471	6.78e-164	XK27_12140	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_00472	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HOLOBFIM_00473	1.05e-161	-	-	-	K	ko:K20488	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
HOLOBFIM_00474	9.88e-251	-	2.7.13.3	-	T	ko:K20487	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HOLOBFIM_00475	7.96e-180	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
HOLOBFIM_00476	4.21e-266	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HOLOBFIM_00477	1.14e-117	-	-	-	-	-	-	-	-
HOLOBFIM_00478	0.0	prtP	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HOLOBFIM_00479	0.0	prtP	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HOLOBFIM_00480	0.0	pepN	3.4.11.2	-	E	ko:K01256	ko00480,ko01100,map00480,map01100	ko00000,ko00001,ko01000,ko01002	aminopeptidase
HOLOBFIM_00481	0.0	ycaM	-	-	E	-	-	-	amino acid
HOLOBFIM_00482	1.66e-117	-	-	-	S	ko:K08996	-	ko00000	Protein of unknown function (DUF1440)
HOLOBFIM_00483	4.74e-211	-	-	-	K	-	-	-	Transcriptional regulator, LysR family
HOLOBFIM_00484	1.56e-204	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
HOLOBFIM_00485	7.27e-180	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HOLOBFIM_00486	2.17e-211	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOLOBFIM_00487	6.33e-275	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HOLOBFIM_00488	5.17e-65	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOLOBFIM_00489	2.61e-136	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOLOBFIM_00490	2.74e-206	metA	2.3.1.46	-	E	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Transfers an acetyl group from acetyl-CoA to
HOLOBFIM_00491	2.2e-222	cysK	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the cysteine synthase cystathionine beta- synthase family
HOLOBFIM_00492	2.14e-24	-	-	-	-	-	-	-	-
HOLOBFIM_00494	2.56e-272	mccB	4.4.1.1, 4.4.1.2, 4.4.1.8	-	E	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	cystathionine
HOLOBFIM_00495	6.84e-186	tcyA	-	-	ET	ko:K02424	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko02035	Belongs to the bacterial solute-binding protein 3 family
HOLOBFIM_00496	1.42e-157	tcyB	-	-	E	ko:K10009	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_00497	3.47e-45	-	-	-	-	-	-	-	-
HOLOBFIM_00498	0.0	brnQ	-	-	U	ko:K03311	-	ko00000	Component of the transport system for branched-chain amino acids
HOLOBFIM_00499	1.14e-151	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_00500	1.73e-225	-	-	-	S	-	-	-	Cell surface protein
HOLOBFIM_00501	1.78e-58	-	-	-	-	-	-	-	-
HOLOBFIM_00502	7.09e-244	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
HOLOBFIM_00503	1.66e-154	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_00504	7.85e-141	-	-	-	N	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_00505	0.0	-	-	-	S	-	-	-	Leucine-rich repeat (LRR) protein
HOLOBFIM_00506	6.94e-225	yicL	-	-	EG	-	-	-	EamA-like transporter family
HOLOBFIM_00507	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_00508	4.3e-186	CcmA5	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_00509	4.07e-114	-	-	-	S	-	-	-	ECF-type riboflavin transporter, S component
HOLOBFIM_00510	8.69e-191	pdxK	2.7.1.35	-	H	ko:K00868	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko01000	Phosphomethylpyrimidine kinase
HOLOBFIM_00511	3.21e-210	metF	1.5.1.20	-	C	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
HOLOBFIM_00512	0.0	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOLOBFIM_00513	0.0	XK27_09600	-	-	V	ko:K06147,ko:K18891	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00514	0.0	-	-	-	V	ko:K06147,ko:K18892	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_00515	3.34e-286	oxlT	-	-	P	ko:K08177	-	ko00000,ko02000	Major Facilitator Superfamily
HOLOBFIM_00516	5.43e-167	treR	-	-	K	ko:K03486	-	ko00000,ko03000	UTRA
HOLOBFIM_00517	0.0	treC	3.2.1.93	GH13	G	ko:K01226	ko00500,map00500	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HOLOBFIM_00518	0.0	treB	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_00519	1.51e-283	sstT	-	-	U	ko:K07862	-	ko00000,ko02000	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HOLOBFIM_00520	0.0	-	-	-	E	ko:K03294	-	ko00000	Amino Acid
HOLOBFIM_00521	1.13e-221	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	lactate/malate dehydrogenase, alpha/beta C-terminal domain
HOLOBFIM_00522	0.0	gdhA	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Belongs to the Glu Leu Phe Val dehydrogenases family
HOLOBFIM_00523	3.08e-43	cspA	-	-	K	ko:K03704	-	ko00000,ko03000	'Cold-shock' DNA-binding domain
HOLOBFIM_00524	1.72e-88	-	-	-	-	-	-	-	-
HOLOBFIM_00525	1.37e-99	-	-	-	O	-	-	-	OsmC-like protein
HOLOBFIM_00526	0.0	yjcA	-	-	S	ko:K19350	ko02010,map02010	ko00000,ko00001,ko01504,ko02000	ABC transporter
HOLOBFIM_00527	2.73e-147	ylbE	-	-	GM	-	-	-	NAD(P)H-binding
HOLOBFIM_00528	1.3e-200	-	-	-	S	-	-	-	Aldo/keto reductase family
HOLOBFIM_00529	9.04e-317	yifK	-	-	E	ko:K03293	-	ko00000	Amino acid permease
HOLOBFIM_00530	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF3800)
HOLOBFIM_00531	0.0	nhaK	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HOLOBFIM_00532	5.49e-78	-	-	-	S	-	-	-	Protein of unknown function (DUF3021)
HOLOBFIM_00533	3.44e-95	-	-	-	K	-	-	-	LytTr DNA-binding domain
HOLOBFIM_00534	2.19e-191	-	-	-	V	ko:K11051	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-2 type transporter
HOLOBFIM_00535	3.89e-210	-	-	-	V	ko:K01990,ko:K11050	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_00536	5.05e-187	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HOLOBFIM_00537	3.16e-158	cah	4.2.1.1	-	P	ko:K01674	ko00910,map00910	ko00000,ko00001,ko01000	Eukaryotic-type carbonic anhydrase
HOLOBFIM_00538	1.06e-69	ybjQ	-	-	S	-	-	-	Belongs to the UPF0145 family
HOLOBFIM_00539	2.92e-203	-	-	-	C	-	-	-	nadph quinone reductase
HOLOBFIM_00540	3.8e-316	amt	-	-	P	ko:K03320	-	ko00000,ko02000	ammonium transporter
HOLOBFIM_00541	3.26e-226	ywbN	-	-	P	ko:K07223,ko:K16301	-	ko00000,ko01000,ko02000	Peroxidase
HOLOBFIM_00542	2.22e-154	yqgG	-	-	S	ko:K07507	-	ko00000,ko02000	MgtC family
HOLOBFIM_00543	1.98e-147	endA	-	-	F	ko:K15051	-	ko00000	DNA RNA non-specific endonuclease
HOLOBFIM_00544	1.03e-22	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
HOLOBFIM_00548	2.24e-32	-	-	-	-	-	-	-	-
HOLOBFIM_00550	8.43e-17	mesE	-	-	M	ko:K12293,ko:K20345	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	Transport protein ComB
HOLOBFIM_00553	3.21e-05	-	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Psort location CytoplasmicMembrane, score
HOLOBFIM_00554	6.33e-157	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	proteolysis
HOLOBFIM_00555	0.0	ykpA	-	-	S	-	-	-	ABC transporter, ATP-binding protein
HOLOBFIM_00556	0.0	-	-	-	L	-	-	-	ATPase domain of DNA mismatch repair MUTS family
HOLOBFIM_00557	2.99e-144	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
HOLOBFIM_00558	3.84e-170	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HOLOBFIM_00559	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
HOLOBFIM_00560	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOLOBFIM_00561	6.49e-176	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HOLOBFIM_00562	4.69e-282	galK	2.7.1.6	-	F	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HOLOBFIM_00563	4.24e-247	galE	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family
HOLOBFIM_00564	0.0	galT	2.7.7.12	-	G	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	ko00000,ko00001,ko00002,ko01000	UDP-glucose--hexose-1-phosphate uridylyltransferase
HOLOBFIM_00565	6.88e-218	msmR	-	-	K	ko:K02529	-	ko00000,ko03000	Transcriptional regulator
HOLOBFIM_00566	2.81e-234	galM	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the interconversion of alpha and beta anomers of maltose
HOLOBFIM_00569	2.36e-111	-	2.7.1.204	-	G	ko:K20112	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_00570	2.68e-67	-	2.7.1.204	-	G	ko:K20113	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_00571	0.0	gatC	-	-	G	ko:K20114	ko02060,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_00572	9.83e-37	-	-	-	-	-	-	-	-
HOLOBFIM_00573	2.22e-160	-	-	-	S	-	-	-	Domain of unknown function (DUF4867)
HOLOBFIM_00574	4.29e-226	lacC	2.7.1.144	-	H	ko:K00917	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HOLOBFIM_00575	1.03e-239	lacD	4.1.2.40	-	G	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	ko00000,ko00001,ko01000	Belongs to the aldolase LacD family
HOLOBFIM_00576	4.53e-122	lacB	5.3.1.26	-	G	ko:K01819	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Ribose/Galactose Isomerase
HOLOBFIM_00577	1.25e-96	lacA	5.3.1.26	-	G	ko:K01819	ko00052,ko01100,map00052,map01100	ko00000,ko00001,ko01000	Ribose/Galactose Isomerase
HOLOBFIM_00578	2.79e-179	-	-	-	K	ko:K02530	-	ko00000,ko03000	DeoR C terminal sensor domain
HOLOBFIM_00579	3.73e-150	-	-	-	S	-	-	-	HAD hydrolase, family IA, variant
HOLOBFIM_00580	3.23e-270	sbcD	-	-	L	ko:K03547	-	ko00000,ko03400	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
HOLOBFIM_00581	0.0	sbcC	-	-	L	ko:K03546	-	ko00000,ko03400	Putative exonuclease SbcCD, C subunit
HOLOBFIM_00582	6.8e-21	-	-	-	-	-	-	-	-
HOLOBFIM_00584	7.42e-112	hsp1	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HOLOBFIM_00586	1.87e-271	mutY	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	A G-specific adenine glycosylase
HOLOBFIM_00587	2.23e-191	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HOLOBFIM_00588	4.31e-156	yrkL	-	-	S	-	-	-	Flavodoxin-like fold
HOLOBFIM_00590	2.6e-113	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HOLOBFIM_00591	1.92e-153	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
HOLOBFIM_00592	9.5e-199	thiD	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
HOLOBFIM_00593	3.35e-252	-	-	-	-	-	-	-	-
HOLOBFIM_00595	1.39e-149	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
HOLOBFIM_00596	0.0	bglB	3.2.1.21, 3.2.1.52	GH3	G	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	ko00000,ko00001,ko00002,ko01000	hydrolase, family 3
HOLOBFIM_00597	3.73e-214	XK27_00670	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter substrate binding protein
HOLOBFIM_00598	2.07e-213	XK27_00670	-	-	S	ko:K01989,ko:K05832	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_00599	4.81e-208	WQ51_06230	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HOLOBFIM_00600	3.37e-180	-	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00601	2.37e-222	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Zinc-binding dehydrogenase
HOLOBFIM_00602	0.0	pacL3	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
HOLOBFIM_00603	8.07e-233	ykcC	-	GT2	M	ko:K20534	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferase family 2
HOLOBFIM_00604	0.0	ykcB	-	-	M	-	-	-	Dolichyl-phosphate-mannose-protein mannosyltransferase
HOLOBFIM_00605	3.08e-93	-	-	-	S	-	-	-	GtrA-like protein
HOLOBFIM_00606	3.91e-159	ciaR	-	-	K	ko:K14983	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
HOLOBFIM_00607	1.74e-308	ciaH	2.7.13.3	-	T	ko:K14982	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
HOLOBFIM_00608	2.42e-88	-	-	-	S	-	-	-	Belongs to the HesB IscA family
HOLOBFIM_00609	0.0	-	-	-	QT	-	-	-	PucR C-terminal helix-turn-helix domain
HOLOBFIM_00610	6.47e-208	-	-	-	S	-	-	-	KR domain
HOLOBFIM_00611	2.43e-205	adc	4.1.1.4	-	Q	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	ko00000,ko00001,ko00002,ko01000	Acetoacetate decarboxylase (ADC)
HOLOBFIM_00612	1.45e-157	ydgI	-	-	C	-	-	-	Nitroreductase family
HOLOBFIM_00613	1.84e-262	lldD	1.13.12.4	-	C	ko:K00467	ko00620,map00620	ko00000,ko00001,ko01000	IMP dehydrogenase / GMP reductase domain
HOLOBFIM_00616	1.53e-243	-	-	-	K	-	-	-	DNA-binding helix-turn-helix protein
HOLOBFIM_00617	1.17e-77	-	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HOLOBFIM_00618	2.7e-62	ygbF	-	-	S	-	-	-	Sugar efflux transporter for intercellular exchange
HOLOBFIM_00619	4.91e-55	-	-	-	-	-	-	-	-
HOLOBFIM_00620	4.75e-244	-	1.1.1.1, 1.6.5.5	-	C	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
HOLOBFIM_00622	1.32e-71	-	-	-	-	-	-	-	-
HOLOBFIM_00623	1.79e-104	-	-	-	-	-	-	-	-
HOLOBFIM_00624	5.77e-267	XK27_05220	-	-	S	-	-	-	AI-2E family transporter
HOLOBFIM_00625	1.58e-33	-	-	-	-	-	-	-	-
HOLOBFIM_00626	9.86e-146	lexA	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HOLOBFIM_00627	8.86e-60	-	-	-	-	-	-	-	-
HOLOBFIM_00628	8.47e-214	mleP2	-	-	S	ko:K07088	-	ko00000	Transporter, auxin efflux carrier (AEC) family protein
HOLOBFIM_00629	2.92e-116	-	-	-	S	-	-	-	Flavin reductase like domain
HOLOBFIM_00630	1.7e-91	-	-	-	-	-	-	-	-
HOLOBFIM_00631	1.09e-129	fthC	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HOLOBFIM_00632	1.7e-81	yeaO	-	-	S	-	-	-	Protein of unknown function, DUF488
HOLOBFIM_00633	2.2e-223	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HOLOBFIM_00634	2.93e-202	mleR	-	-	K	-	-	-	LysR family
HOLOBFIM_00635	0.0	mleS	1.1.1.38, 4.1.1.101	-	C	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme
HOLOBFIM_00636	3.58e-217	mleP	-	-	S	ko:K07088	-	ko00000	Sodium Bile acid symporter family
HOLOBFIM_00637	8.23e-117	tpx	1.11.1.15	-	O	ko:K11065	-	ko00000,ko01000	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HOLOBFIM_00638	1.08e-111	-	-	-	C	-	-	-	FMN binding
HOLOBFIM_00639	0.0	pepF	-	-	E	-	-	-	Oligopeptidase F
HOLOBFIM_00640	6.41e-77	-	-	-	-	-	-	-	-
HOLOBFIM_00641	1.55e-169	-	-	-	IQ	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HOLOBFIM_00642	4.06e-107	ndk	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	Belongs to the NDK family
HOLOBFIM_00643	0.0	yfgQ	-	-	P	ko:K12952	-	ko00000,ko01000	E1-E2 ATPase
HOLOBFIM_00644	4.48e-230	-	3.4.11.5	-	I	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	carboxylic ester hydrolase activity
HOLOBFIM_00645	1.69e-58	-	-	-	-	-	-	-	-
HOLOBFIM_00646	1.4e-121	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOLOBFIM_00647	1.14e-255	napA	-	-	P	-	-	-	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
HOLOBFIM_00648	7.46e-157	XK27_05175	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	haloacid dehalogenase-like hydrolase
HOLOBFIM_00649	2.24e-101	-	-	-	K	-	-	-	Transcriptional regulator
HOLOBFIM_00650	2.4e-231	ybcH	-	-	D	ko:K06889	-	ko00000	Alpha beta
HOLOBFIM_00651	1.56e-108	nrdI	-	-	F	ko:K03647	-	ko00000	Belongs to the NrdI family
HOLOBFIM_00652	2.52e-199	dkgB	-	-	S	-	-	-	reductase
HOLOBFIM_00653	4.76e-201	-	-	-	-	-	-	-	-
HOLOBFIM_00654	1.02e-197	-	-	-	S	-	-	-	Alpha beta hydrolase
HOLOBFIM_00655	3.16e-151	yviA	-	-	S	-	-	-	Protein of unknown function (DUF421)
HOLOBFIM_00656	4.49e-97	-	-	-	S	-	-	-	Protein of unknown function (DUF3290)
HOLOBFIM_00657	5.92e-284	metE	2.1.1.14	-	E	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	methionine synthase, vitamin-B12 independent
HOLOBFIM_00658	1.69e-112	luxS	4.4.1.21	-	H	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	ko00000,ko00001,ko00002,ko01000	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
HOLOBFIM_00659	1.3e-136	yjbF	-	-	S	-	-	-	SNARE associated Golgi protein
HOLOBFIM_00660	2.95e-133	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
HOLOBFIM_00661	4.54e-241	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
HOLOBFIM_00662	7.52e-263	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HOLOBFIM_00663	3.46e-289	tgt	2.4.2.29	-	F	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
HOLOBFIM_00664	4.49e-88	yajC	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HOLOBFIM_00665	0.0	adhE	1.1.1.1, 1.2.1.10	-	C	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	belongs to the iron- containing alcohol dehydrogenase family
HOLOBFIM_00666	2.06e-150	mntR	-	-	K	ko:K03709	-	ko00000,ko03000	Helix-turn-helix diphteria tox regulatory element
HOLOBFIM_00667	0.0	zwf	1.1.1.363, 1.1.1.49	-	G	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HOLOBFIM_00668	1.71e-262	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOLOBFIM_00669	6.53e-307	ytoI	-	-	K	-	-	-	DRTGG domain
HOLOBFIM_00670	1.75e-228	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HOLOBFIM_00671	0.0	cshB	3.6.4.13	-	JKL	ko:K05592,ko:K18692	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures
HOLOBFIM_00672	5.18e-222	-	-	-	-	-	-	-	-
HOLOBFIM_00673	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOLOBFIM_00675	1.99e-57	yrzL	-	-	S	-	-	-	Belongs to the UPF0297 family
HOLOBFIM_00676	2.67e-96	yrrK	-	-	J	ko:K07447	-	ko00000,ko01000	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOLOBFIM_00677	1.3e-69	yrzB	-	-	S	-	-	-	Belongs to the UPF0473 family
HOLOBFIM_00678	2.84e-48	-	-	-	D	ko:K09888	-	ko00000,ko03036	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HOLOBFIM_00679	1.89e-119	cvpA	-	-	S	-	-	-	Colicin V production protein
HOLOBFIM_00680	0.0	mutS2	-	-	L	ko:K07456	ko03430,map03430	ko00000,ko00001,ko03400	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
HOLOBFIM_00681	3.64e-70	trxA	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Belongs to the thioredoxin family
HOLOBFIM_00682	1.04e-27	dltX	-	-	S	-	-	-	D-Ala-teichoic acid biosynthesis protein
HOLOBFIM_00683	0.0	dltA	6.1.1.13	-	H	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HOLOBFIM_00684	9.86e-304	dltB	-	-	M	ko:K03739	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	MBOAT, membrane-bound O-acyltransferase family
HOLOBFIM_00685	6.97e-49	dltC	6.1.1.13	-	J	ko:K14188	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall
HOLOBFIM_00686	2.89e-312	dltD	-	-	M	ko:K03740	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01504	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HOLOBFIM_00687	6.77e-111	yslB	-	-	S	-	-	-	Protein of unknown function (DUF2507)
HOLOBFIM_00688	0.0	murI	3.6.1.66, 5.1.1.3	-	M	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100	ko00000,ko00001,ko01000,ko01011	Provides the (R)-glutamate required for cell wall biosynthesis
HOLOBFIM_00689	1.64e-125	ysnB	-	-	S	ko:K07095	-	ko00000	Phosphoesterase
HOLOBFIM_00690	1.9e-175	gla	-	-	U	ko:K02440	-	ko00000,ko02000	Major intrinsic protein
HOLOBFIM_00691	9.32e-112	ykuL	-	-	S	-	-	-	CBS domain
HOLOBFIM_00692	2.4e-201	-	-	-	S	ko:K08974	-	ko00000	Domain of unknown function (DUF368)
HOLOBFIM_00693	1.38e-197	ykuT	-	-	M	ko:K16052,ko:K22044	-	ko00000,ko02000	mechanosensitive ion channel
HOLOBFIM_00694	2.12e-46	ytxG	-	-	S	-	-	-	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HOLOBFIM_00695	4.84e-114	ytxH	-	-	S	-	-	-	YtxH-like protein
HOLOBFIM_00696	7.49e-117	yrxA	-	-	S	ko:K07105	-	ko00000	3H domain
HOLOBFIM_00697	2.2e-274	pepQ	3.4.13.9	-	E	ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HOLOBFIM_00698	3.03e-232	ccpA	-	-	K	ko:K02529	-	ko00000,ko03000	catabolite control protein A
HOLOBFIM_00699	0.0	pbp1B	2.4.1.129	GT51	M	ko:K03693,ko:K12551	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Penicillin binding protein transpeptidase domain
HOLOBFIM_00700	1.06e-163	yfnB	3.8.1.2	-	S	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	ko00000,ko00001,ko01000	HAD-hyrolase-like
HOLOBFIM_00701	3.4e-176	birA	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor
HOLOBFIM_00702	0.0	pepV	3.5.1.18	-	E	ko:K01270,ko:K01274,ko:K01439	ko00300,ko00480,ko01100,ko01120,ko01230,map00300,map00480,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000,ko01002	dipeptidase PepV
HOLOBFIM_00703	0.0	glpQ	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	Glycerophosphoryl diester phosphodiesterase family
HOLOBFIM_00704	9.98e-73	-	-	-	-	-	-	-	-
HOLOBFIM_00705	8.45e-241	yibE	-	-	S	-	-	-	overlaps another CDS with the same product name
HOLOBFIM_00706	3.27e-151	yibF	-	-	S	-	-	-	overlaps another CDS with the same product name
HOLOBFIM_00707	2.04e-145	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HOLOBFIM_00708	0.0	yunD	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the 5'-nucleotidase family
HOLOBFIM_00709	2.93e-150	yutD	-	-	S	-	-	-	Protein of unknown function (DUF1027)
HOLOBFIM_00710	1.1e-185	nagD	3.1.3.41	-	G	ko:K01101	ko00627,ko01120,map00627,map01120	ko00000,ko00001,ko01000	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro
HOLOBFIM_00711	2.62e-145	-	-	-	S	-	-	-	Protein of unknown function (DUF1461)
HOLOBFIM_00712	8.69e-149	dedA	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
HOLOBFIM_00713	2.26e-115	pgpA	3.1.3.27	-	I	ko:K01095	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phosphatidylglycerophosphatase A
HOLOBFIM_00714	1.35e-237	yumC	1.18.1.2, 1.19.1.1	-	C	ko:K21567	-	ko00000,ko01000	Ferredoxin--NADP reductase
HOLOBFIM_00715	2.99e-140	ppiB	5.2.1.8	-	G	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOLOBFIM_00716	1.17e-82	yugI	-	-	J	ko:K07570	-	ko00000	general stress protein
HOLOBFIM_00717	1.45e-46	-	-	-	-	-	-	-	-
HOLOBFIM_00718	5.19e-90	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HOLOBFIM_00746	8.3e-123	sigH	-	-	K	ko:K03088,ko:K03091,ko:K12296	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko03000,ko03021	DNA-templated transcription, initiation
HOLOBFIM_00747	0.0	ybeC	-	-	E	-	-	-	amino acid
HOLOBFIM_00748	1.09e-294	pimB	2.4.1.337	GT4	M	ko:K19002	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HOLOBFIM_00749	1.13e-252	cpoA	2.4.1.208	GT4	M	ko:K13677,ko:K13678	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000,ko01003	Glycosyltransferase, group 1 family protein
HOLOBFIM_00750	1.58e-220	mprF	-	-	I	ko:K07027	-	ko00000,ko02000	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HOLOBFIM_00752	8.08e-280	araT	-	-	E	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HOLOBFIM_00753	1.52e-57	ykuJ	-	-	S	-	-	-	Protein of unknown function (DUF1797)
HOLOBFIM_00754	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HOLOBFIM_00755	8.92e-105	perR	-	-	P	ko:K03711,ko:K09825	-	ko00000,ko03000	Belongs to the Fur family
HOLOBFIM_00756	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_00757	1.45e-46	-	-	-	-	-	-	-	-
HOLOBFIM_00758	5.19e-90	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HOLOBFIM_00763	4.87e-92	-	-	-	-	-	-	-	-
HOLOBFIM_00764	7.89e-268	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOLOBFIM_00765	0.0	mdr	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_00766	4.66e-105	-	-	-	K	-	-	-	MerR HTH family regulatory protein
HOLOBFIM_00767	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HOLOBFIM_00768	7.54e-155	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HOLOBFIM_00769	2.89e-152	yodM	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Acid phosphatase homologues
HOLOBFIM_00770	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Belongs to the class-I aminoacyl-tRNA synthetase family
HOLOBFIM_00771	0.0	ytgP	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HOLOBFIM_00772	9.39e-167	rsuA	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HOLOBFIM_00773	1.58e-45	yhcC	-	-	S	ko:K07069	-	ko00000	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HOLOBFIM_00774	3.93e-182	nnrD	4.2.1.136, 5.1.99.6	-	H	ko:K17758,ko:K17759	-	ko00000,ko01000	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HOLOBFIM_00775	2.18e-122	-	-	-	F	-	-	-	NUDIX domain
HOLOBFIM_00777	1.46e-226	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HOLOBFIM_00781	1.7e-122	-	-	-	V	-	-	-	Type I restriction
HOLOBFIM_00782	2.1e-13	-	-	-	M	-	-	-	Host cell surface-exposed lipoprotein
HOLOBFIM_00783	2.39e-24	-	-	-	E	-	-	-	Zn peptidase
HOLOBFIM_00784	7.64e-56	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_00786	1.37e-148	-	-	-	S	-	-	-	ORF6N domain
HOLOBFIM_00788	3.8e-56	-	-	-	S	-	-	-	Domain of unknown function (DUF1883)
HOLOBFIM_00795	7.15e-175	-	-	-	L	-	-	-	Helix-turn-helix domain
HOLOBFIM_00796	4.68e-195	pi346	-	-	L	ko:K02315	-	ko00000,ko03032	IstB-like ATP binding protein
HOLOBFIM_00798	1.1e-93	-	-	-	-	-	-	-	-
HOLOBFIM_00799	3.95e-168	-	-	-	-	-	-	-	-
HOLOBFIM_00802	1.46e-68	-	-	-	-	-	-	-	-
HOLOBFIM_00803	4e-60	-	-	-	-	-	-	-	-
HOLOBFIM_00804	1.81e-19	-	-	-	-	-	-	-	-
HOLOBFIM_00805	8.06e-280	-	-	-	S	-	-	-	GcrA cell cycle regulator
HOLOBFIM_00806	8.57e-66	-	-	-	-	-	-	-	-
HOLOBFIM_00808	3.59e-91	-	-	-	L	-	-	-	HNH nucleases
HOLOBFIM_00809	4.9e-100	-	-	-	S	-	-	-	Phage terminase, small subunit
HOLOBFIM_00810	0.0	-	-	-	S	-	-	-	Phage Terminase
HOLOBFIM_00812	4.02e-300	-	-	-	S	-	-	-	Phage portal protein
HOLOBFIM_00813	3.31e-149	-	-	-	S	-	-	-	peptidase activity
HOLOBFIM_00814	8.47e-264	-	-	-	S	-	-	-	peptidase activity
HOLOBFIM_00815	3.42e-36	-	-	-	S	-	-	-	peptidase activity
HOLOBFIM_00816	2.93e-34	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HOLOBFIM_00817	2.28e-51	-	-	-	S	-	-	-	Phage head-tail joining protein
HOLOBFIM_00818	4.48e-85	-	-	-	S	-	-	-	exonuclease activity
HOLOBFIM_00819	2.65e-38	-	-	-	-	-	-	-	-
HOLOBFIM_00820	1.19e-93	-	-	-	S	-	-	-	Pfam:Phage_TTP_1
HOLOBFIM_00821	2.72e-27	-	-	-	-	-	-	-	-
HOLOBFIM_00822	0.0	-	-	-	S	-	-	-	peptidoglycan catabolic process
HOLOBFIM_00823	3.84e-174	-	-	-	S	-	-	-	Phage tail protein
HOLOBFIM_00824	1.46e-201	-	-	-	S	-	-	-	cellulase activity
HOLOBFIM_00825	2.94e-16	-	-	-	-	-	-	-	-
HOLOBFIM_00827	2.17e-58	-	-	-	-	-	-	-	-
HOLOBFIM_00828	4.47e-81	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
HOLOBFIM_00829	2.21e-106	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HOLOBFIM_00831	0.0	tagE2	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HOLOBFIM_00832	0.0	tagE3	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HOLOBFIM_00833	9.78e-112	gpo	1.11.1.9	-	O	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	ko00000,ko00001,ko01000	Belongs to the glutathione peroxidase family
HOLOBFIM_00836	1.05e-296	patB	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase, class I
HOLOBFIM_00837	0.0	cpdA	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HOLOBFIM_00838	5.05e-52	XK27_08630	-	-	T	ko:K07166	-	ko00000	Belongs to the UPF0237 family
HOLOBFIM_00839	3.93e-312	XK27_08635	-	-	S	ko:K09157	-	ko00000	UPF0210 protein
HOLOBFIM_00840	1.21e-272	coiA	-	-	S	ko:K06198	-	ko00000	Competence protein
HOLOBFIM_00841	3.71e-147	yjbH	-	-	Q	-	-	-	Thioredoxin
HOLOBFIM_00842	7.28e-138	-	-	-	S	-	-	-	CYTH
HOLOBFIM_00843	1.19e-158	yjbM	2.7.6.5	-	S	ko:K07816	ko00230,map00230	ko00000,ko00001,ko01000	RelA SpoT domain protein
HOLOBFIM_00844	1.05e-193	nadK	2.7.1.23	-	F	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HOLOBFIM_00845	2.88e-218	yjbO	5.4.99.23	-	G	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HOLOBFIM_00846	9.8e-259	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HOLOBFIM_00847	1.51e-146	cutC	-	-	P	ko:K06201	-	ko00000	Participates in the control of copper homeostasis
HOLOBFIM_00848	1.09e-183	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
HOLOBFIM_00849	9.35e-254	pgl	3.1.1.31	-	G	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Lactonase, 7-bladed beta-propeller
HOLOBFIM_00850	8.13e-82	srlB	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
HOLOBFIM_00851	4.12e-56	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOLOBFIM_00852	4.94e-245	guaC	1.7.1.7	-	F	ko:K00364	ko00230,map00230	ko00000,ko00001,ko01000	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
HOLOBFIM_00853	1.94e-219	corA	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
HOLOBFIM_00854	3.44e-200	rrmA	2.1.1.187	-	H	ko:K00563,ko:K10947	-	ko00000,ko01000,ko03000,ko03009	Methyltransferase
HOLOBFIM_00855	3.21e-125	cspR	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
HOLOBFIM_00856	4.04e-94	-	-	-	S	-	-	-	Protein of unknown function (DUF1149)
HOLOBFIM_00857	0.0	ftsK	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HOLOBFIM_00858	2.12e-292	ymfF	-	-	S	-	-	-	Peptidase M16 inactive domain protein
HOLOBFIM_00859	3.78e-307	ymfH	-	-	S	-	-	-	Peptidase M16
HOLOBFIM_00860	3.01e-166	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HOLOBFIM_00861	1.15e-169	ymfM	-	-	S	ko:K15539	-	ko00000	Helix-turn-helix domain
HOLOBFIM_00862	9.93e-136	pgsA	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOLOBFIM_00863	1.05e-293	cinA	3.5.1.42	-	S	ko:K03742,ko:K03743	ko00760,map00760	ko00000,ko00001,ko01000	Belongs to the CinA family
HOLOBFIM_00864	8.81e-242	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOLOBFIM_00865	7.95e-317	rny	-	-	S	ko:K18682	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Endoribonuclease that initiates mRNA decay
HOLOBFIM_00866	4.86e-150	yvyE	3.4.13.9	-	S	ko:K01271	-	ko00000,ko01000,ko01002	YigZ family
HOLOBFIM_00867	5.49e-300	comFA	-	-	L	ko:K02240	-	ko00000,ko00002,ko02044	Helicase C-terminal domain protein
HOLOBFIM_00868	2.49e-103	comFC	-	-	S	ko:K02242	-	ko00000,ko00002,ko02044	Competence protein
HOLOBFIM_00869	3.24e-126	hpf	-	-	J	ko:K05808	-	ko00000,ko03009	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOLOBFIM_00870	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
HOLOBFIM_00871	8.69e-239	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HOLOBFIM_00872	1.28e-160	ftsE	-	-	D	ko:K09812	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03036	ABC transporter
HOLOBFIM_00874	3.16e-258	minJ	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
HOLOBFIM_00875	1.83e-168	phoP	-	-	K	ko:K07658	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HOLOBFIM_00876	0.0	phoR	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HOLOBFIM_00877	1.76e-196	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HOLOBFIM_00878	4.48e-205	pstC	-	-	P	ko:K02037	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	probably responsible for the translocation of the substrate across the membrane
HOLOBFIM_00879	1.06e-201	pstA	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphate transport system permease protein PstA
HOLOBFIM_00880	1.57e-192	pstB2	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HOLOBFIM_00881	3.54e-180	pstB1	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
HOLOBFIM_00882	3.82e-156	phoU	-	-	P	ko:K02039	-	ko00000	Plays a role in the regulation of phosphate uptake
HOLOBFIM_00883	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_00884	0.0	yvlB	-	-	S	-	-	-	Putative adhesin
HOLOBFIM_00885	5.23e-50	-	-	-	-	-	-	-	-
HOLOBFIM_00886	3.07e-50	yvlD	-	-	S	ko:K08972	-	ko00000	Mycobacterial 4 TMS phage holin, superfamily IV
HOLOBFIM_00887	8.27e-223	hprK	-	-	F	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HOLOBFIM_00888	7.94e-202	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HOLOBFIM_00889	6.29e-250	gpsA	1.1.1.94	-	I	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	Glycerol-3-phosphate dehydrogenase
HOLOBFIM_00890	7.1e-227	trxB	1.8.1.9	-	C	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
HOLOBFIM_00891	0.0	pgm	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain
HOLOBFIM_00892	1.51e-148	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HOLOBFIM_00893	1.27e-219	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
HOLOBFIM_00894	2.43e-117	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_00895	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HOLOBFIM_00896	1.99e-153	yfbR	-	-	S	ko:K07023	-	ko00000	HD containing hydrolase-like enzyme
HOLOBFIM_00897	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
HOLOBFIM_00898	0.0	uvrA	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
HOLOBFIM_00899	2.56e-111	-	-	-	S	-	-	-	Short repeat of unknown function (DUF308)
HOLOBFIM_00900	8.53e-213	yvcJ	-	-	S	ko:K06958	-	ko00000,ko03019	Displays ATPase and GTPase activities
HOLOBFIM_00901	1.22e-247	yvcK	-	-	S	-	-	-	Required for morphogenesis under gluconeogenic growth conditions
HOLOBFIM_00902	9.63e-220	whiA	-	-	K	ko:K09762	-	ko00000	May be required for sporulation
HOLOBFIM_00903	3.19e-105	ohrR	-	-	K	ko:K18906	-	ko00000,ko00002,ko01504,ko03000	helix_turn_helix multiple antibiotic resistance protein
HOLOBFIM_00904	5.97e-132	clpP	3.4.21.92	-	O	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
HOLOBFIM_00906	3.11e-29	-	-	-	M	-	-	-	Host cell surface-exposed lipoprotein
HOLOBFIM_00908	5.52e-241	cggR	-	-	K	ko:K05311	-	ko00000,ko03000	Putative sugar-binding domain
HOLOBFIM_00909	2.1e-247	gap	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
HOLOBFIM_00910	2.16e-282	pgk	2.7.2.3	-	F	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the phosphoglycerate kinase family
HOLOBFIM_00911	2.81e-180	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
HOLOBFIM_00912	2.05e-313	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HOLOBFIM_00913	2.69e-232	mdt(A)	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
HOLOBFIM_00914	3.37e-38	mdt(A)	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
HOLOBFIM_00915	2.21e-62	-	-	-	-	-	-	-	-
HOLOBFIM_00916	0.0	eriC	-	-	P	ko:K03281	-	ko00000	chloride
HOLOBFIM_00917	5.04e-43	secG	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase
HOLOBFIM_00918	1.34e-179	est	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	Serine aminopeptidase, S33
HOLOBFIM_00919	0.0	rnr	-	-	J	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
HOLOBFIM_00920	4.47e-108	smpB	-	-	J	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
HOLOBFIM_00921	1.89e-227	yvdE	-	-	K	-	-	-	helix_turn _helix lactose operon repressor
HOLOBFIM_00922	3.06e-297	malA1	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
HOLOBFIM_00923	3.25e-93	malA1	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
HOLOBFIM_00924	0.0	nplT	3.2.1.133, 3.2.1.135, 3.2.1.54	GH13	G	ko:K01208	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HOLOBFIM_00925	0.0	mapA	2.4.1.8	GH65	G	ko:K00691	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	hydrolase, family 65, central catalytic
HOLOBFIM_00926	2.02e-154	-	5.4.2.6	-	S	ko:K01838	ko00500,map00500	ko00000,ko00001,ko01000	Haloacid dehalogenase-like hydrolase
HOLOBFIM_00927	5.02e-20	msmX	-	-	P	ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_00928	9.45e-23	-	-	-	-	-	-	-	-
HOLOBFIM_00929	1.13e-32	-	-	-	K	ko:K07729	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
HOLOBFIM_00930	3.08e-307	YSH1	-	-	S	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Metallo-beta-lactamase superfamily
HOLOBFIM_00931	8.67e-312	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HOLOBFIM_00932	1.1e-188	malF	-	-	G	ko:K02026	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_00933	7.01e-213	-	-	-	P	ko:K02025	-	ko00000,ko00002,ko02000	ABC-type sugar transport systems, permease components
HOLOBFIM_00934	8.83e-248	malK	-	-	P	ko:K10112,ko:K17240	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_00935	3.63e-136	-	-	-	K	ko:K06977	-	ko00000	Acetyltransferase (GNAT) domain
HOLOBFIM_00936	7.57e-119	-	-	-	-	-	-	-	-
HOLOBFIM_00937	4e-203	ycsE	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_00938	8.4e-166	ung	3.2.2.27	-	L	ko:K03648	ko03410,ko05340,map03410,map05340	ko00000,ko00001,ko01000,ko03400	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOLOBFIM_00939	1.75e-227	pta	2.3.1.8, 3.6.3.21	-	C	ko:K00625,ko:K02028	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000,ko02000	phosphate acetyltransferase
HOLOBFIM_00940	1.57e-106	ydiB	-	-	O	ko:K06925	-	ko00000,ko03016	Hydrolase, P-loop family
HOLOBFIM_00941	4.05e-18	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_00942	1.21e-209	ysdB	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_00943	1.8e-275	ysdA	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_00944	8.04e-129	dnaQ	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HOLOBFIM_00945	6.69e-193	exoA	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease III
HOLOBFIM_00946	1.59e-211	murB	1.3.1.98	-	M	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation
HOLOBFIM_00947	0.0	yvgP	-	-	P	ko:K03316	-	ko00000	Sodium proton antiporter
HOLOBFIM_00948	1.97e-124	-	-	-	K	-	-	-	Cupin domain
HOLOBFIM_00949	9.1e-263	potA	3.6.3.30, 3.6.3.31	-	P	ko:K02010,ko:K11072	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
HOLOBFIM_00950	1.44e-189	potB	-	-	P	ko:K11071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_00951	2.88e-187	potC	-	-	P	ko:K11070	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_00952	3.46e-266	potD	-	-	P	ko:K11069	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_00954	0.0	pacL	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
HOLOBFIM_00955	1.82e-144	-	-	-	K	-	-	-	Transcriptional regulator
HOLOBFIM_00956	1.62e-241	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_00957	1.09e-169	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HOLOBFIM_00958	3.82e-195	dacA	2.7.7.85	-	S	ko:K18672	-	ko00000,ko01000	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HOLOBFIM_00959	6.7e-216	ybbR	-	-	S	-	-	-	YbbR-like protein
HOLOBFIM_00960	0.0	glmM	5.4.2.10	-	G	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko01000	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOLOBFIM_00961	0.0	glmS	2.6.1.16	-	M	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	ko00000,ko00001,ko01000,ko01002	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
HOLOBFIM_00963	0.0	pepF2	-	-	E	-	-	-	Oligopeptidase F
HOLOBFIM_00964	3.35e-106	-	-	-	S	-	-	-	VanZ like family
HOLOBFIM_00965	5.85e-169	yebC	-	-	K	-	-	-	Transcriptional regulatory protein
HOLOBFIM_00966	8.14e-195	comGA	-	-	NU	ko:K02243	-	ko00000,ko00002,ko02044	Type II IV secretion system protein
HOLOBFIM_00967	3.22e-218	comGB	-	-	NU	ko:K02244	-	ko00000,ko00002,ko02044	type II secretion system
HOLOBFIM_00968	1e-35	-	-	-	-	ko:K02245	-	ko00000,ko00002,ko02044	-
HOLOBFIM_00970	3.85e-31	-	-	-	-	-	-	-	-
HOLOBFIM_00971	1.42e-24	-	-	-	-	ko:K02248	-	ko00000,ko00002,ko02044	-
HOLOBFIM_00973	3.06e-238	ytxK	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
HOLOBFIM_00974	2.1e-81	-	-	-	-	-	-	-	-
HOLOBFIM_00975	0.0	cycA	-	-	E	ko:K03293,ko:K11737	-	ko00000,ko02000	Amino acid permease
HOLOBFIM_00976	7.51e-191	arbV	-	-	I	-	-	-	Phosphate acyltransferases
HOLOBFIM_00977	8.22e-212	arbx	-	-	M	-	-	-	Glycosyl transferase family 8
HOLOBFIM_00978	5.46e-232	arbY	-	-	M	-	-	-	family 8
HOLOBFIM_00979	9.24e-214	arbZ	-	-	I	-	-	-	Phosphate acyltransferases
HOLOBFIM_00980	0.0	rafA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
HOLOBFIM_00983	9.31e-93	-	-	-	S	-	-	-	SdpI/YhfL protein family
HOLOBFIM_00984	1.02e-173	yclJ	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
HOLOBFIM_00985	0.0	yclK	-	-	T	-	-	-	Histidine kinase
HOLOBFIM_00986	4.67e-97	-	-	-	S	-	-	-	acetyltransferase
HOLOBFIM_00987	7.39e-20	-	-	-	-	-	-	-	-
HOLOBFIM_00988	7.36e-94	pheB	5.4.99.5	-	S	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the UPF0735 family
HOLOBFIM_00989	1.53e-88	-	-	-	-	-	-	-	-
HOLOBFIM_00990	8.56e-74	-	-	-	-	-	-	-	-
HOLOBFIM_00991	0.0	polYB	2.7.7.7	-	L	ko:K02346,ko:K03502	-	ko00000,ko01000,ko03400	Belongs to the DNA polymerase type-Y family
HOLOBFIM_00993	1.78e-266	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
HOLOBFIM_00994	5.83e-179	-	3.1.1.5	-	E	ko:K10804	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	GDSL-like Lipase/Acylhydrolase
HOLOBFIM_00995	5.65e-46	-	-	-	S	-	-	-	Bacterial protein of unknown function (DUF898)
HOLOBFIM_00997	0.0	pcrA	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase
HOLOBFIM_00998	0.0	ligA	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOLOBFIM_00999	4.26e-271	camS	-	-	S	-	-	-	sex pheromone
HOLOBFIM_01000	3.61e-61	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOLOBFIM_01001	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
HOLOBFIM_01002	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOLOBFIM_01003	4.97e-248	dagK	2.7.1.107	-	G	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko01000	Lipid kinase
HOLOBFIM_01004	0.0	rumA_2	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOLOBFIM_01005	6.51e-281	yttB	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_01006	8.81e-191	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_01007	1.21e-210	-	-	-	S	-	-	-	Polyphosphate nucleotide phosphotransferase, PPK2 family
HOLOBFIM_01008	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HOLOBFIM_01009	0.0	-	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_01010	5.98e-105	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
HOLOBFIM_01011	2.87e-213	yitS	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HOLOBFIM_01012	3.38e-166	hflC	-	-	O	ko:K04087	-	ko00000,ko00002,ko01000	prohibitin homologues
HOLOBFIM_01013	1.24e-39	-	-	-	-	-	-	-	-
HOLOBFIM_01014	1.02e-179	-	-	-	M	ko:K07273	-	ko00000	Glycosyl hydrolases family 25
HOLOBFIM_01015	9.39e-80	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HOLOBFIM_01016	1.9e-79	-	-	-	S	-	-	-	Domain of unknown function (DUF4828)
HOLOBFIM_01017	1.55e-226	mocA	-	-	S	-	-	-	Oxidoreductase
HOLOBFIM_01018	2.09e-303	yfmL	-	-	L	-	-	-	DEAD DEAH box helicase
HOLOBFIM_01019	2.76e-74	chbA	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOLOBFIM_01020	4.49e-93	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HOLOBFIM_01022	4.16e-07	-	-	-	-	-	-	-	-
HOLOBFIM_01023	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HOLOBFIM_01025	3.32e-305	pepS	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	Thermophilic metalloprotease (M29)
HOLOBFIM_01026	2.96e-144	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_01028	0.0	-	-	-	S	ko:K13730	ko05100,map05100	ko00000,ko00001	Uncharacterized protein conserved in bacteria (DUF2252)
HOLOBFIM_01029	9.73e-230	rbn	-	-	S	ko:K07058	-	ko00000	Belongs to the UPF0761 family
HOLOBFIM_01030	1.24e-103	fld	-	-	C	ko:K03839	-	ko00000	Flavodoxin
HOLOBFIM_01031	1.16e-204	map	3.4.11.18	-	E	ko:K01265	-	ko00000,ko01000,ko01002	Methionine Aminopeptidase
HOLOBFIM_01032	5.25e-259	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HOLOBFIM_01034	1.02e-20	-	-	-	-	-	-	-	-
HOLOBFIM_01035	4.45e-253	mvaK2	2.7.4.2	-	I	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	phosphomevalonate kinase
HOLOBFIM_01036	4.58e-217	galU	2.7.7.9	-	M	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP-glucose-1-phosphate uridylyltransferase
HOLOBFIM_01038	8.71e-59	-	-	-	L	ko:K07483	-	ko00000	4.5 Transposon and IS
HOLOBFIM_01039	7.23e-200	-	-	-	L	ko:K07497	-	ko00000	4.5 Transposon and IS
HOLOBFIM_01041	7.23e-200	-	-	-	L	ko:K07497	-	ko00000	4.5 Transposon and IS
HOLOBFIM_01042	8.71e-59	-	-	-	L	ko:K07483	-	ko00000	4.5 Transposon and IS
HOLOBFIM_01043	2.61e-94	-	-	-	S	-	-	-	Cell surface protein
HOLOBFIM_01045	0.0	-	-	-	N	-	-	-	domain, Protein
HOLOBFIM_01046	0.0	-	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HOLOBFIM_01047	0.0	bglH	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_01048	7.14e-191	licT2	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
HOLOBFIM_01049	0.0	-	-	-	S	-	-	-	Bacterial membrane protein YfhO
HOLOBFIM_01050	0.0	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HOLOBFIM_01051	3.35e-217	yfdH	-	GT2	M	ko:K12999	-	ko00000,ko01000,ko01003,ko01005	Glycosyltransferase, group 2 family protein
HOLOBFIM_01052	2.1e-133	-	-	-	-	-	-	-	-
HOLOBFIM_01053	8.49e-217	yqjA	-	-	S	-	-	-	Putative aromatic acid exporter C-terminal domain
HOLOBFIM_01054	6.22e-43	cspC	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HOLOBFIM_01055	3.95e-108	yvbK	-	-	K	-	-	-	GNAT family
HOLOBFIM_01056	1.45e-149	acmA	3.2.1.17, 3.2.1.96	-	NU	ko:K01185,ko:K01227	ko00511,map00511	ko00000,ko00001,ko01000	mannosyl-glycoprotein
HOLOBFIM_01057	5.35e-133	xpt	2.4.2.22	-	F	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis
HOLOBFIM_01058	1.47e-301	pbuX	-	-	F	ko:K03458,ko:K16169	-	ko00000,ko02000	xanthine permease
HOLOBFIM_01059	1.15e-261	purK2	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HOLOBFIM_01060	9.74e-315	purB	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOLOBFIM_01061	7.65e-136	-	-	-	-	-	-	-	-
HOLOBFIM_01062	6.04e-137	-	-	-	-	-	-	-	-
HOLOBFIM_01063	0.0	ltaS	2.7.8.20	-	M	ko:K19005	ko00561,ko01100,map00561,map01100	ko00000,ko00001,ko01000	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
HOLOBFIM_01064	3.74e-142	vanZ	-	-	V	-	-	-	VanZ like family
HOLOBFIM_01065	4.66e-196	glcU	-	-	U	ko:K05340	-	ko00000,ko02000	sugar transport
HOLOBFIM_01066	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the GPI family
HOLOBFIM_01067	6.08e-179	-	-	-	S	-	-	-	Domain of unknown function DUF1829
HOLOBFIM_01068	6.86e-60	ycnE	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
HOLOBFIM_01070	6.34e-193	-	-	-	F	ko:K15051	-	ko00000	DNA/RNA non-specific endonuclease
HOLOBFIM_01071	2.73e-71	-	-	-	S	-	-	-	Pfam Transposase IS66
HOLOBFIM_01072	1.87e-292	-	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	Glycosyl transferases group 1
HOLOBFIM_01073	3.64e-219	ysjB	-	-	S	ko:K03810	-	ko00000	Oxidoreductase family, NAD-binding Rossmann fold
HOLOBFIM_01074	2.32e-109	guaD	-	-	FJ	-	-	-	MafB19-like deaminase
HOLOBFIM_01077	8.59e-103	tspO	-	-	T	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	ko00000,ko00001,ko02000	TspO/MBR family
HOLOBFIM_01078	1.53e-19	-	-	-	-	-	-	-	-
HOLOBFIM_01079	4.42e-271	yttB	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_01080	1.03e-63	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_01081	7.59e-48	-	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_01082	0.0	pepD2	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HOLOBFIM_01085	4.1e-163	pgm7	-	-	G	-	-	-	Phosphoglycerate mutase family
HOLOBFIM_01086	2.61e-154	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_01087	0.0	ycfI	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01088	0.0	yfiC	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HOLOBFIM_01089	2.13e-180	-	-	-	S	-	-	-	NADPH-dependent FMN reductase
HOLOBFIM_01090	2.26e-209	catE	1.13.11.2	-	S	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	glyoxalase
HOLOBFIM_01091	8.75e-250	ampC	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_01092	0.0	murE2	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Domain of unknown function (DUF1727)
HOLOBFIM_01093	4.41e-143	tdk	2.7.1.21	-	F	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	thymidine kinase
HOLOBFIM_01094	8.62e-252	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOLOBFIM_01095	5.46e-195	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
HOLOBFIM_01096	1.99e-237	ywlC	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
HOLOBFIM_01097	4.49e-298	glyA	2.1.2.1	-	E	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOLOBFIM_01098	7.2e-144	upp	2.4.2.9	-	F	ko:K00761	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HOLOBFIM_01099	1.23e-162	atpB	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	it plays a direct role in the translocation of protons across the membrane
HOLOBFIM_01100	2.57e-37	atpE	-	-	C	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOLOBFIM_01101	1.13e-83	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOLOBFIM_01102	2.28e-115	atpH	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOLOBFIM_01103	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HOLOBFIM_01104	1.92e-211	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOLOBFIM_01105	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOLOBFIM_01106	1.88e-91	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
HOLOBFIM_01107	8.38e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF1146)
HOLOBFIM_01108	4.12e-228	mbl	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Cell shape determining protein MreB Mrl
HOLOBFIM_01109	1.37e-26	-	-	-	S	-	-	-	DNA-directed RNA polymerase subunit beta
HOLOBFIM_01110	1.14e-72	ytjA	-	-	S	ko:K08998	-	ko00000	Could be involved in insertion of integral membrane proteins into the membrane
HOLOBFIM_01111	8.37e-42	-	-	-	S	-	-	-	Protein of unknown function (DUF2969)
HOLOBFIM_01112	1.41e-285	rodA	-	-	D	ko:K05837	-	ko00000,ko03036	Belongs to the SEDS family
HOLOBFIM_01113	4.19e-65	gcsH2	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	glycine cleavage
HOLOBFIM_01114	8.94e-267	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HOLOBFIM_01115	1.88e-186	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HOLOBFIM_01116	8.04e-192	-	-	-	P	ko:K02073	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the nlpA lipoprotein family
HOLOBFIM_01117	2.09e-243	metN	-	-	P	ko:K02071	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOLOBFIM_01118	7.6e-149	metI	-	-	P	ko:K02072	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01119	4.15e-184	sufC	-	-	O	ko:K09013	-	ko00000,ko02000	FeS assembly ATPase SufC
HOLOBFIM_01120	2.73e-243	sufD	-	-	O	ko:K07033,ko:K09015	-	ko00000	FeS assembly protein SufD
HOLOBFIM_01121	1.03e-281	sufS	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOLOBFIM_01122	2.01e-102	nifU	-	-	C	ko:K04488	-	ko00000	SUF system FeS assembly protein, NifU family
HOLOBFIM_01123	0.0	sufB	-	-	O	ko:K07033,ko:K09014	-	ko00000	assembly protein SufB
HOLOBFIM_01124	4.73e-31	-	-	-	-	-	-	-	-
HOLOBFIM_01125	9.85e-88	-	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HOLOBFIM_01126	3.03e-231	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
HOLOBFIM_01127	1.06e-149	yhfA	-	-	S	-	-	-	HAD hydrolase, family IA, variant 3
HOLOBFIM_01128	2.7e-200	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_01129	2.86e-108	uspA	-	-	T	-	-	-	universal stress protein
HOLOBFIM_01130	1.65e-52	-	-	-	-	-	-	-	-
HOLOBFIM_01131	6.77e-306	rarA	-	-	L	ko:K07478	-	ko00000	recombination factor protein RarA
HOLOBFIM_01132	0.0	gshAB	6.3.2.2	-	H	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the glutamate--cysteine ligase type 1 family
HOLOBFIM_01133	2.76e-99	XK27_05190	-	-	S	-	-	-	Protein of unknown function (DUF1694)
HOLOBFIM_01134	7e-142	yktB	-	-	S	-	-	-	Belongs to the UPF0637 family
HOLOBFIM_01135	1.02e-158	sdaAB	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase beta chain
HOLOBFIM_01136	4.62e-193	sdaAA	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	L-serine dehydratase, iron-sulfur-dependent, alpha subunit
HOLOBFIM_01137	5.43e-157	-	-	-	G	-	-	-	alpha-ribazole phosphatase activity
HOLOBFIM_01138	3.44e-198	mrsA1	1.8.4.11	-	O	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOLOBFIM_01139	1.17e-218	-	-	-	IQ	-	-	-	NAD dependent epimerase/dehydratase family
HOLOBFIM_01140	2.93e-178	pnuC	-	-	H	ko:K03811	-	ko00000,ko02000	nicotinamide mononucleotide transporter
HOLOBFIM_01141	2.05e-173	-	-	-	F	-	-	-	deoxynucleoside kinase
HOLOBFIM_01142	8.16e-203	hisK	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidinol phosphatase and related hydrolases of the PHP family
HOLOBFIM_01143	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HOLOBFIM_01144	1.19e-200	-	-	-	T	-	-	-	GHKL domain
HOLOBFIM_01145	4.47e-155	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HOLOBFIM_01146	1.17e-217	bcrA	-	-	V	ko:K01990,ko:K19309	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HOLOBFIM_01147	1.8e-142	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_01148	3.86e-203	-	-	-	K	-	-	-	Transcriptional regulator
HOLOBFIM_01149	9.11e-101	yphH	-	-	S	-	-	-	Cupin domain
HOLOBFIM_01150	1.07e-72	yphJ	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	decarboxylase
HOLOBFIM_01151	6.15e-146	-	-	-	GM	-	-	-	NAD(P)H-binding
HOLOBFIM_01152	1.12e-53	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HOLOBFIM_01153	1.93e-157	gst	2.5.1.18	-	O	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	ko00000,ko00001,ko01000,ko02000	Glutathione S-transferase, C-terminal domain
HOLOBFIM_01154	4.54e-118	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
HOLOBFIM_01155	9.28e-218	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01156	3.03e-115	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01157	7.56e-160	-	-	-	T	-	-	-	Histidine kinase
HOLOBFIM_01158	2.65e-110	-	-	-	K	ko:K07720	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, arabinose operon control protein
HOLOBFIM_01159	3.72e-194	-	-	-	P	ko:K02012	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HOLOBFIM_01160	8.48e-197	fbpC	3.6.3.30	-	P	ko:K02010	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	TOBE domain
HOLOBFIM_01161	1.17e-313	sfuB	-	-	P	ko:K02011	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_01162	9.8e-198	degV	-	-	S	-	-	-	Uncharacterised protein, DegV family COG1307
HOLOBFIM_01163	2.7e-131	desR	-	-	K	ko:K02479,ko:K07693	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
HOLOBFIM_01164	2.23e-193	desK	2.7.13.3	-	T	ko:K07778	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HOLOBFIM_01165	1.58e-121	XK27_09830	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 type transporter
HOLOBFIM_01166	9.97e-157	yvfR	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_01167	1.57e-267	-	-	-	-	-	-	-	-
HOLOBFIM_01168	2.54e-87	-	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HOLOBFIM_01169	2.23e-62	-	-	-	S	-	-	-	Protein of unknown function (DUF2568)
HOLOBFIM_01170	0.0	tex	-	-	K	ko:K06959	-	ko00000	Tex-like protein N-terminal domain protein
HOLOBFIM_01171	8.53e-88	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
HOLOBFIM_01172	0.0	-	-	-	L	-	-	-	AAA domain
HOLOBFIM_01173	5.31e-143	rpsD	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOLOBFIM_01174	7.1e-111	yebR	1.8.4.14	-	T	ko:K08968	ko00270,map00270	ko00000,ko00001,ko01000	GAF domain-containing protein
HOLOBFIM_01175	0.0	ezrA	-	-	D	ko:K06286	-	ko00000,ko03036	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HOLOBFIM_01176	3.53e-271	iscS2	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HOLOBFIM_01177	9.99e-288	thiI	2.8.1.4	-	H	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOLOBFIM_01178	1.24e-148	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HOLOBFIM_01179	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
HOLOBFIM_01180	7.32e-307	folC	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the folylpolyglutamate synthase family
HOLOBFIM_01181	1.98e-148	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
HOLOBFIM_01182	1.97e-152	radC	-	-	L	ko:K03630	-	ko00000	DNA repair protein
HOLOBFIM_01183	4.82e-229	mreB	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	cell shape determining protein MreB
HOLOBFIM_01184	1.88e-191	mreC	-	-	M	ko:K03570	-	ko00000,ko03036	Involved in formation and maintenance of cell shape
HOLOBFIM_01185	1.23e-112	mreD	-	-	M	ko:K03571	-	ko00000,ko03036	rod shape-determining protein MreD
HOLOBFIM_01186	2.69e-148	minC	-	-	D	ko:K03610	-	ko00000,ko03036,ko04812	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
HOLOBFIM_01187	8.63e-182	minD	-	-	D	ko:K03609	-	ko00000,ko03036,ko04812	Belongs to the ParA family
HOLOBFIM_01188	4.79e-142	yecS_2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01189	3.29e-146	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter
HOLOBFIM_01190	2.32e-193	aatB	-	-	ET	ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter substrate-binding protein
HOLOBFIM_01191	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOLOBFIM_01192	7.11e-60	-	-	-	-	-	-	-	-
HOLOBFIM_01193	1.61e-101	mraZ	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
HOLOBFIM_01194	6.77e-219	rsmH	2.1.1.199	-	J	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
HOLOBFIM_01195	1.6e-68	ftsL	-	-	D	-	-	-	cell division protein FtsL
HOLOBFIM_01196	0.0	pbpX	-	-	M	ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HOLOBFIM_01197	1.33e-230	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HOLOBFIM_01198	0.0	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HOLOBFIM_01199	4e-259	murG	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HOLOBFIM_01200	3.57e-201	divIB	-	-	D	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex
HOLOBFIM_01201	1.44e-311	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
HOLOBFIM_01202	3.25e-291	ftsZ	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HOLOBFIM_01203	7.24e-102	sepF	-	-	D	ko:K09772	-	ko00000,ko03036	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA
HOLOBFIM_01204	5.58e-60	ylmG	-	-	S	ko:K02221	-	ko00000,ko02044	integral membrane protein
HOLOBFIM_01205	2.81e-184	ylmH	-	-	S	-	-	-	S4 domain protein
HOLOBFIM_01206	3.27e-117	divIVA	-	-	D	ko:K04074	-	ko00000,ko03036	DivIVA protein
HOLOBFIM_01207	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HOLOBFIM_01208	4.62e-48	cspB	-	-	K	ko:K03704	-	ko00000,ko03000	Cold shock protein
HOLOBFIM_01209	5.93e-207	pstS	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	Phosphate
HOLOBFIM_01210	0.0	ydiC1	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_01211	7.29e-270	yaaN	-	-	P	-	-	-	Toxic anion resistance protein (TelA)
HOLOBFIM_01212	9.37e-150	-	-	-	S	-	-	-	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HOLOBFIM_01213	5.24e-124	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	ADP-ribose pyrophosphatase
HOLOBFIM_01214	1.42e-39	-	-	-	-	-	-	-	-
HOLOBFIM_01215	1.95e-159	mtnN	3.2.2.9	-	E	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOLOBFIM_01216	2.81e-278	iscS	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class V
HOLOBFIM_01217	2.45e-75	XK27_04120	-	-	S	-	-	-	Putative amino acid metabolism
HOLOBFIM_01218	0.0	uvrA2	-	-	L	-	-	-	ABC transporter
HOLOBFIM_01219	1.01e-304	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
HOLOBFIM_01221	4.69e-159	pgm6	-	-	G	-	-	-	phosphoglycerate mutase
HOLOBFIM_01222	1.62e-151	-	-	-	S	-	-	-	repeat protein
HOLOBFIM_01223	0.0	recD2	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
HOLOBFIM_01224	2.86e-312	-	-	-	S	-	-	-	Sterol carrier protein domain
HOLOBFIM_01225	1.15e-232	ytlR	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HOLOBFIM_01226	0.0	rnjA	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HOLOBFIM_01227	2.02e-43	ykzG	-	-	S	-	-	-	Belongs to the UPF0356 family
HOLOBFIM_01228	1.11e-95	-	-	-	-	-	-	-	-
HOLOBFIM_01229	1.73e-63	-	-	-	-	-	-	-	-
HOLOBFIM_01230	4.82e-132	def	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
HOLOBFIM_01231	3.42e-110	-	-	-	S	-	-	-	E1-E2 ATPase
HOLOBFIM_01232	1.42e-267	pdhA	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
HOLOBFIM_01233	1.15e-232	pdhB	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, C-terminal domain protein
HOLOBFIM_01234	0.0	pdhC	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
HOLOBFIM_01235	0.0	pdhD	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Dehydrogenase
HOLOBFIM_01236	1.24e-201	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	L-malate dehydrogenase activity
HOLOBFIM_01237	6.15e-62	yktA	-	-	S	-	-	-	Belongs to the UPF0223 family
HOLOBFIM_01238	3.56e-189	suhB	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the inositol monophosphatase superfamily
HOLOBFIM_01239	0.0	typA	-	-	T	ko:K06207	-	ko00000	GTP-binding protein TypA
HOLOBFIM_01240	4.76e-269	ftsW	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Belongs to the SEDS family
HOLOBFIM_01241	0.0	pyc	6.4.1.1	-	C	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HOLOBFIM_01242	8.46e-84	ylbG	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2129)
HOLOBFIM_01243	9.93e-130	rsmD	2.1.1.171	-	L	ko:K08316	-	ko00000,ko01000,ko03009	RNA methyltransferase, RsmD family
HOLOBFIM_01244	4.38e-113	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOLOBFIM_01245	1.82e-233	lon	-	-	T	ko:K07177	ko02024,map02024	ko00000,ko00001,ko01002	Belongs to the peptidase S16 family
HOLOBFIM_01246	1.73e-146	comEA	-	-	L	ko:K02237	-	ko00000,ko00002,ko02044	Competence protein ComEA
HOLOBFIM_01247	0.0	comEC	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein ComEC
HOLOBFIM_01248	5.08e-222	holA	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III delta subunit
HOLOBFIM_01249	1.44e-47	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 16S ribosomal RNA
HOLOBFIM_01250	5e-57	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HOLOBFIM_01251	4.12e-64	-	-	-	-	-	-	-	-
HOLOBFIM_01252	0.0	rnjB	-	-	J	ko:K12574	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HOLOBFIM_01253	1.93e-213	-	-	-	S	-	-	-	Tetratricopeptide repeat
HOLOBFIM_01254	4.73e-286	tuf	-	-	J	ko:K02358,ko:K15771	ko02010,map02010	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOLOBFIM_01255	0.0	yknV	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter
HOLOBFIM_01256	9.55e-288	tig	-	-	D	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
HOLOBFIM_01257	1.19e-296	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HOLOBFIM_01258	2.74e-138	engB	-	-	D	ko:K03978	-	ko00000,ko03036	Necessary for normal cell division and for the maintenance of normal septation
HOLOBFIM_01259	2.28e-63	-	-	-	S	-	-	-	mazG nucleotide pyrophosphohydrolase
HOLOBFIM_01260	3.33e-28	-	-	-	-	-	-	-	-
HOLOBFIM_01261	0.0	glnPH2	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01262	1.89e-172	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01263	0.0	uvrC	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
HOLOBFIM_01264	0.0	fruA	2.7.1.202	-	GT	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase System
HOLOBFIM_01265	2.76e-218	pfkB	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	Belongs to the carbohydrate kinase PfkB family. LacC subfamily
HOLOBFIM_01266	2.78e-170	fruR	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
HOLOBFIM_01267	3.37e-309	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOLOBFIM_01268	0.0	oatA	-	-	I	-	-	-	Acyltransferase
HOLOBFIM_01269	2.71e-233	rnz	3.1.26.11	-	J	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
HOLOBFIM_01270	1.83e-183	yqjQ	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
HOLOBFIM_01271	4.1e-64	-	-	-	S	-	-	-	Lipopolysaccharide assembly protein A domain
HOLOBFIM_01272	0.0	clpB	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HOLOBFIM_01273	1.35e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
HOLOBFIM_01274	6.3e-123	-	-	-	K	-	-	-	Domain of unknown function (DUF1836)
HOLOBFIM_01275	0.0	ycjM	3.1.3.5, 3.1.3.6, 3.1.4.16	-	F	ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	5'-nucleotidase, C-terminal domain
HOLOBFIM_01276	2.47e-184	-	-	-	-	-	-	-	-
HOLOBFIM_01277	8.1e-36	-	-	-	S	-	-	-	Protein of unknown function (DUF2929)
HOLOBFIM_01278	0.0	dnaE	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase
HOLOBFIM_01279	2.21e-227	pfkA	2.7.1.11	-	F	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
HOLOBFIM_01280	0.0	pyk	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Belongs to the pyruvate kinase family
HOLOBFIM_01281	4.31e-95	ytwI	-	-	S	-	-	-	Protein of unknown function (DUF441)
HOLOBFIM_01282	3.45e-206	yitL	-	-	S	ko:K00243	-	ko00000	S1 domain
HOLOBFIM_01283	2.34e-209	xerD	-	-	D	ko:K04763	-	ko00000,ko03036	recombinase XerD
HOLOBFIM_01284	1.59e-88	ribT	-	-	K	ko:K02859	-	ko00000	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
HOLOBFIM_01285	1.07e-159	scpA	-	-	D	ko:K05896	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HOLOBFIM_01286	8.74e-139	scpB	-	-	D	ko:K06024	-	ko00000,ko03036	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HOLOBFIM_01287	6.35e-175	rluB	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	Belongs to the pseudouridine synthase RsuA family
HOLOBFIM_01288	4.35e-123	ribU	-	-	U	-	-	-	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HOLOBFIM_01289	1.16e-60	fer	-	-	C	ko:K05337	-	ko00000	4Fe-4S single cluster domain of Ferredoxin I
HOLOBFIM_01290	3.4e-230	-	-	-	S	-	-	-	Helix-turn-helix domain
HOLOBFIM_01291	0.0	recQ	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	ATP-dependent DNA helicase RecQ
HOLOBFIM_01292	1.68e-104	-	-	-	M	-	-	-	Lysin motif
HOLOBFIM_01293	2.04e-149	cmk	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the cytidylate kinase family. Type 1 subfamily
HOLOBFIM_01294	1.72e-303	rpsA	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S1
HOLOBFIM_01295	7.41e-312	der	-	-	S	ko:K03977	-	ko00000,ko03009	GTPase that plays an essential role in the late steps of ribosome biogenesis
HOLOBFIM_01296	1.2e-54	hup	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
HOLOBFIM_01297	1.25e-301	XK27_05225	-	-	S	-	-	-	Tetratricopeptide repeat protein
HOLOBFIM_01298	8.71e-200	ypjC	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOLOBFIM_01299	6.19e-283	cca	2.7.7.72	-	J	ko:K00974	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HOLOBFIM_01300	2.95e-110	-	-	-	-	-	-	-	-
HOLOBFIM_01301	0.0	yfmR	-	-	S	ko:K15738	-	ko00000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01302	6.7e-241	thyA	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HOLOBFIM_01303	4.09e-116	folA	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HOLOBFIM_01304	1.83e-148	hlyIII	-	-	S	ko:K11068	-	ko00000,ko02042	protein, hemolysin III
HOLOBFIM_01305	4.9e-190	WQ51_01275	-	-	S	-	-	-	EDD domain protein, DegV family
HOLOBFIM_01306	2.41e-196	XK27_03630	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
HOLOBFIM_01307	3.18e-147	ypmS	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2140)
HOLOBFIM_01308	6.11e-111	msrA	1.8.4.11	-	C	ko:K07304	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOLOBFIM_01309	1.03e-54	yozE	-	-	S	-	-	-	Belongs to the UPF0346 family
HOLOBFIM_01310	9.98e-315	ctpA	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	Belongs to the peptidase S41A family
HOLOBFIM_01311	8.99e-64	-	-	-	K	-	-	-	Helix-turn-helix domain
HOLOBFIM_01312	1.46e-204	rbgA	-	-	S	ko:K14540	-	ko00000,ko03009	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HOLOBFIM_01313	2.31e-178	rnhB	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOLOBFIM_01314	1.82e-186	dprA	-	-	LU	ko:K04096	-	ko00000	DNA protecting protein DprA
HOLOBFIM_01315	0.0	topA	5.99.1.2	-	L	ko:K03168	-	ko00000,ko01000,ko03032,ko03400	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HOLOBFIM_01316	0.0	trmFO	2.1.1.74	-	J	ko:K04094	-	ko00000,ko01000,ko03016,ko03036	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HOLOBFIM_01317	6.77e-216	xerC	-	-	D	ko:K03733,ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family. XerC subfamily
HOLOBFIM_01318	2.06e-119	hslV	3.4.25.2	-	O	ko:K01419	-	ko00000,ko01000,ko01002	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HOLOBFIM_01319	0.0	hslU	-	-	O	ko:K03667	-	ko00000,ko03110	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HOLOBFIM_01320	1.27e-217	lacX	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Aldose 1-epimerase
HOLOBFIM_01321	6.92e-141	plsY	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
HOLOBFIM_01322	0.0	parE	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HOLOBFIM_01323	0.0	parC	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
HOLOBFIM_01324	0.0	pflB	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
HOLOBFIM_01325	2.56e-217	pflA	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOLOBFIM_01326	2.6e-232	-	-	-	K	-	-	-	LysR substrate binding domain
HOLOBFIM_01327	5.59e-221	ppaC	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	inorganic pyrophosphatase
HOLOBFIM_01328	3.33e-266	xerS	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
HOLOBFIM_01329	7.18e-79	-	-	-	-	-	-	-	-
HOLOBFIM_01330	0.0	XK27_05700	-	-	V	ko:K02004,ko:K19084	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	FtsX-like permease family
HOLOBFIM_01331	1.09e-175	XK27_05695	-	-	V	ko:K02003,ko:K19083	ko02010,ko02020,map02010,map02020	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01332	1.65e-217	kinG	-	-	T	-	-	-	Histidine kinase-like ATPases
HOLOBFIM_01333	1.96e-156	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
HOLOBFIM_01334	1.3e-241	-	-	-	EGP	ko:K08217	-	br01600,ko00000,ko01504,ko02000	Transmembrane secretion effector
HOLOBFIM_01335	1.44e-62	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01336	1.73e-93	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01337	2.92e-144	-	-	-	C	-	-	-	Nitroreductase family
HOLOBFIM_01338	2.07e-261	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOLOBFIM_01339	6.09e-70	hisE	3.6.1.31	-	E	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	phosphoribosyl-ATP diphosphatase activity
HOLOBFIM_01340	1.01e-77	hisI	3.5.4.19, 3.6.1.31	-	E	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HOLOBFIM_01341	1.42e-169	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
HOLOBFIM_01342	3.23e-159	hisA	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HOLOBFIM_01343	4.02e-145	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOLOBFIM_01344	3.22e-135	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	imidazoleglycerol-phosphate dehydratase
HOLOBFIM_01345	2.79e-293	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOLOBFIM_01346	3.41e-143	hisG	2.4.2.17	-	F	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
HOLOBFIM_01347	4.47e-277	hisZ	-	-	E	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HOLOBFIM_01348	2.42e-261	hisC	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOLOBFIM_01349	2.36e-129	-	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	Belongs to the Nudix hydrolase family
HOLOBFIM_01350	2.95e-205	-	-	-	S	-	-	-	EDD domain protein, DegV family
HOLOBFIM_01351	0.0	FbpA	-	-	K	-	-	-	Fibronectin-binding protein
HOLOBFIM_01352	8.55e-67	-	-	-	S	-	-	-	MazG-like family
HOLOBFIM_01353	8.21e-250	pfoS/R	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
HOLOBFIM_01354	3.53e-226	panE	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HOLOBFIM_01355	3.16e-281	bfmBB	2.3.1.12, 2.3.1.168	-	C	ko:K00627,ko:K09699	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
HOLOBFIM_01356	8.73e-234	bfmBAB	1.2.4.4	-	C	ko:K00167,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
HOLOBFIM_01357	9.14e-239	bfmBAA	1.2.4.4	-	C	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
HOLOBFIM_01358	0.0	bfmBC	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
HOLOBFIM_01359	2.14e-259	buk	2.7.2.7	-	C	ko:K00929	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	Acetokinase family
HOLOBFIM_01360	1.01e-189	ptb	2.3.1.19	-	C	ko:K00634	ko00650,ko01100,map00650,map01100	ko00000,ko00001,ko01000	Phosphate acetyl/butaryl transferase
HOLOBFIM_01361	8.37e-145	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOLOBFIM_01362	3.64e-161	pyrF	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
HOLOBFIM_01363	2.13e-197	pyrD	1.3.1.14, 1.3.98.1	-	F	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
HOLOBFIM_01364	0.0	carB	6.3.5.5	-	F	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase
HOLOBFIM_01365	5.32e-267	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase glutamine chain
HOLOBFIM_01366	1.26e-305	pyrC	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
HOLOBFIM_01367	7.64e-229	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Belongs to the ATCase OTCase family
HOLOBFIM_01368	1.64e-299	pyrP	-	-	F	ko:K02824	-	ko00000,ko02000	Permease
HOLOBFIM_01369	1.05e-125	pyrR	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HOLOBFIM_01370	2.99e-221	rluD	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HOLOBFIM_01371	2.41e-106	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HOLOBFIM_01372	0.0	fhs	6.3.4.3	-	F	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the formate--tetrahydrofolate ligase family
HOLOBFIM_01373	1.21e-60	-	-	-	S	-	-	-	Family of unknown function (DUF5322)
HOLOBFIM_01374	2.37e-91	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HI
HOLOBFIM_01375	2.09e-143	XK27_02070	-	-	S	ko:K07078	-	ko00000	Nitroreductase family
HOLOBFIM_01376	0.0	cls	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOLOBFIM_01377	3.85e-63	-	-	-	-	-	-	-	-
HOLOBFIM_01378	0.0	-	-	-	S	-	-	-	Mga helix-turn-helix domain
HOLOBFIM_01379	8.72e-52	nrdH	-	-	O	ko:K06191	-	ko00000	Glutaredoxin
HOLOBFIM_01380	0.0	nrdE	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOLOBFIM_01381	8.83e-242	nrdF	1.17.4.1	-	F	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOLOBFIM_01382	3.31e-207	lysR	-	-	K	-	-	-	Transcriptional regulator
HOLOBFIM_01383	0.0	pepO	-	-	O	ko:K07386	-	ko00000,ko01000,ko01002	Peptidase family M13
HOLOBFIM_01384	1e-248	lplA	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Lipoate-protein ligase
HOLOBFIM_01385	8.85e-47	-	-	-	-	-	-	-	-
HOLOBFIM_01386	3e-221	serA	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
HOLOBFIM_01387	2.31e-278	ypsC	-	-	L	ko:K07444	-	ko00000,ko01000	Belongs to the methyltransferase superfamily
HOLOBFIM_01389	7.09e-88	gpsB	-	-	D	-	-	-	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation
HOLOBFIM_01390	9.29e-138	ypsA	-	-	S	-	-	-	Belongs to the UPF0398 family
HOLOBFIM_01391	5.12e-157	recU	-	-	L	ko:K03700	-	ko00000,ko03400	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation
HOLOBFIM_01392	0.0	ponA	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein 1A
HOLOBFIM_01393	5.94e-111	comEB	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	ComE operon protein 2
HOLOBFIM_01394	7.61e-148	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HOLOBFIM_01395	3.19e-146	dnaD	-	-	L	ko:K02086	-	ko00000	DnaD domain protein
HOLOBFIM_01396	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Asparaginyl-tRNA synthetase
HOLOBFIM_01397	1.15e-279	aspB	2.6.1.1, 2.6.1.14	-	E	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase
HOLOBFIM_01398	3.5e-112	ypmB	-	-	S	-	-	-	Protein conserved in bacteria
HOLOBFIM_01400	0.0	dinG	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	helicase involved in DNA repair and perhaps also replication
HOLOBFIM_01401	0.0	addA	3.6.4.12	-	L	ko:K16898	-	ko00000,ko01000,ko03400	ATP-dependent helicase nuclease subunit A
HOLOBFIM_01402	0.0	rexB	3.6.4.12	-	L	ko:K16899	-	ko00000,ko01000,ko03400	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' - 3' nuclease activity
HOLOBFIM_01403	5.33e-215	mvk	2.7.1.36	-	I	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	ko00000,ko00001,ko00002,ko01000	mevalonate kinase
HOLOBFIM_01404	5.43e-231	mvaD	4.1.1.33	-	I	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	diphosphomevalonate decarboxylase
HOLOBFIM_01405	1.53e-242	fni	5.3.3.2	-	C	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)
HOLOBFIM_01406	0.0	rsmF	-	-	J	-	-	-	NOL1 NOP2 sun family protein
HOLOBFIM_01407	1.32e-223	-	-	-	-	-	-	-	-
HOLOBFIM_01408	1.24e-181	-	-	-	-	-	-	-	-
HOLOBFIM_01409	2.32e-79	yitW	-	-	S	-	-	-	Iron-sulfur cluster assembly protein
HOLOBFIM_01410	2.03e-35	dmpI	5.3.2.6	-	G	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	ko00000,ko00001,ko00002,ko01000	Belongs to the 4-oxalocrotonate tautomerase family
HOLOBFIM_01411	1.4e-191	yqfO	-	-	S	-	-	-	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HOLOBFIM_01412	1.14e-160	trmK	2.1.1.217	-	S	ko:K06967	-	ko00000,ko01000,ko03016	SAM-dependent methyltransferase
HOLOBFIM_01413	9.19e-249	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
HOLOBFIM_01414	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
HOLOBFIM_01415	0.0	glyS	6.1.1.14	-	J	ko:K01879	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Glycyl-tRNA synthetase beta subunit
HOLOBFIM_01416	3.65e-220	glyQ	6.1.1.14	-	J	ko:K01878	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	glycyl-tRNA synthetase alpha subunit
HOLOBFIM_01417	8.67e-55	-	-	-	-	-	-	-	-
HOLOBFIM_01418	3.64e-70	-	-	-	-	-	-	-	-
HOLOBFIM_01419	2.87e-181	recO	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Involved in DNA repair and RecF pathway recombination
HOLOBFIM_01420	2.76e-216	era	-	-	S	ko:K03595	-	ko00000,ko03009,ko03029	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOLOBFIM_01421	1.38e-84	cdd	3.5.4.5	-	F	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
HOLOBFIM_01422	6.78e-82	dgkA	2.7.1.107, 2.7.1.66	-	M	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	ko00000,ko00001,ko01000	Diacylglycerol kinase
HOLOBFIM_01423	1.03e-106	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOLOBFIM_01424	8.02e-230	phoH	-	-	T	ko:K06217	-	ko00000	phosphate starvation-inducible protein PhoH
HOLOBFIM_01426	1.81e-88	yqeY	-	-	S	ko:K09117	-	ko00000	YqeY-like protein
HOLOBFIM_01427	3.98e-29	rpsU	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bS21 family
HOLOBFIM_01428	8.44e-199	yqfL	2.7.11.33, 2.7.4.28	-	F	ko:K09773	-	ko00000,ko01000	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
HOLOBFIM_01429	4.99e-210	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HOLOBFIM_01430	3.1e-216	yitT	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOLOBFIM_01431	8.83e-107	msrB	1.8.4.12	-	O	ko:K07305	-	ko00000,ko01000	peptide methionine sulfoxide reductase
HOLOBFIM_01432	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
HOLOBFIM_01433	1.32e-310	hisS	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	histidyl-tRNA synthetase
HOLOBFIM_01434	4.56e-47	XK27_04345	3.6.1.1	-	C	ko:K01507	ko00190,map00190	ko00000,ko00001,ko01000	Inorganic pyrophosphatase
HOLOBFIM_01435	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_01436	3.99e-200	-	-	-	V	-	-	-	ABC transporter
HOLOBFIM_01437	2.36e-109	-	-	-	FG	-	-	-	adenosine 5'-monophosphoramidase activity
HOLOBFIM_01438	2.31e-313	lytH	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	N-acetylmuramoyl-L-alanine amidase
HOLOBFIM_01439	1.35e-150	-	-	-	J	-	-	-	HAD-hyrolase-like
HOLOBFIM_01440	1.31e-98	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
HOLOBFIM_01441	0.0	relA	2.7.6.5	-	KT	ko:K00951	ko00230,map00230	ko00000,ko00001,ko01000	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOLOBFIM_01442	5.49e-58	-	-	-	-	-	-	-	-
HOLOBFIM_01443	3.13e-170	rsmE	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
HOLOBFIM_01444	1.17e-220	prmA	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase
HOLOBFIM_01445	1.42e-112	XK27_03960	-	-	S	-	-	-	Protein of unknown function (DUF3013)
HOLOBFIM_01446	4.23e-142	-	3.2.2.21	-	L	ko:K03652	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Belongs to the DNA glycosylase MPG family
HOLOBFIM_01447	2.23e-50	-	-	-	-	-	-	-	-
HOLOBFIM_01448	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_01449	8.05e-88	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HOLOBFIM_01450	6.1e-27	-	-	-	-	-	-	-	-
HOLOBFIM_01451	2.45e-64	-	-	-	-	-	-	-	-
HOLOBFIM_01454	1.13e-153	mocA	-	-	S	-	-	-	Oxidoreductase
HOLOBFIM_01455	0.0	tagE	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon
HOLOBFIM_01456	1.36e-313	-	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	Glycosyl transferases group 1
HOLOBFIM_01459	4.34e-194	-	2.4.1.9, 3.4.24.40	GH68	M	ko:K01406,ko:K20811	ko00500,ko01503,map00500,map01503	ko00000,ko00001,ko01000,ko01002	domain protein
HOLOBFIM_01460	0.000822	-	-	-	M	-	-	-	Domain of unknown function (DUF5011)
HOLOBFIM_01461	5.23e-309	-	-	-	-	-	-	-	-
HOLOBFIM_01462	1.48e-97	-	-	-	-	-	-	-	-
HOLOBFIM_01463	7e-123	-	-	-	-	-	-	-	-
HOLOBFIM_01464	5.9e-190	hutG	3.5.3.8	-	E	ko:K01479	ko00340,ko01100,map00340,map01100	ko00000,ko00001,ko00002,ko01000	N-formylglutamate amidohydrolase
HOLOBFIM_01465	6.77e-71	XK27_08430	-	-	S	-	-	-	Staphylococcal protein of unknown function (DUF960)
HOLOBFIM_01466	2.01e-118	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOLOBFIM_01467	2.82e-122	apt	2.4.2.7	-	F	ko:K00759	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko01000,ko04147	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOLOBFIM_01468	0.0	recJ	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	Single-stranded-DNA-specific exonuclease RecJ
HOLOBFIM_01469	8.85e-76	-	-	-	-	-	-	-	-
HOLOBFIM_01470	5.87e-109	-	-	-	S	-	-	-	ASCH
HOLOBFIM_01471	5.36e-33	-	-	-	-	-	-	-	-
HOLOBFIM_01472	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
HOLOBFIM_01473	6.07e-64	-	-	-	K	ko:K20373	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
HOLOBFIM_01475	3.28e-167	-	-	-	V	-	-	-	ABC transporter transmembrane region
HOLOBFIM_01476	9.45e-261	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
HOLOBFIM_01477	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Heat shock 70 kDa protein
HOLOBFIM_01478	3.18e-127	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOLOBFIM_01479	1.6e-246	hrcA	-	-	K	ko:K03705	-	ko00000,ko03000	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
HOLOBFIM_01480	8.81e-288	hemN	-	-	H	-	-	-	Involved in the biosynthesis of porphyrin-containing compound
HOLOBFIM_01481	6.32e-225	ribF	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Belongs to the ribF family
HOLOBFIM_01482	2.83e-213	truB	5.4.99.25	-	J	ko:K03177,ko:K03483	-	ko00000,ko01000,ko03000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HOLOBFIM_01483	2.58e-182	terC	-	-	P	-	-	-	Integral membrane protein TerC family
HOLOBFIM_01484	1.27e-76	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HOLOBFIM_01485	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HOLOBFIM_01486	1.29e-60	ylxQ	-	-	J	-	-	-	ribosomal protein
HOLOBFIM_01487	1.13e-59	ylxR	-	-	K	ko:K07742	-	ko00000	Protein of unknown function (DUF448)
HOLOBFIM_01488	1.68e-276	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	Participates in both transcription termination and antitermination
HOLOBFIM_01489	1.33e-110	rimP	-	-	J	ko:K09748	-	ko00000,ko03009	Required for maturation of 30S ribosomal subunits
HOLOBFIM_01490	0.0	polC	2.7.7.7	-	L	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HOLOBFIM_01491	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
HOLOBFIM_01492	4.99e-292	rseP	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	zinc metalloprotease
HOLOBFIM_01493	1.27e-177	cdsA	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Belongs to the CDS family
HOLOBFIM_01494	5.24e-180	uppS	2.5.1.31	-	H	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOLOBFIM_01495	4.96e-121	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
HOLOBFIM_01496	5.86e-167	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible phosphorylation of UMP to UDP
HOLOBFIM_01497	1.63e-200	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HOLOBFIM_01498	1.18e-182	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS2 family
HOLOBFIM_01499	5.38e-61	yazA	-	-	L	ko:K07461	-	ko00000	GIY-YIG catalytic domain protein
HOLOBFIM_01500	2.05e-168	yabB	2.1.1.223	-	L	ko:K07461,ko:K15460	-	ko00000,ko01000,ko03016	Methyltransferase small domain
HOLOBFIM_01501	1.71e-159	plsC	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Acyltransferase
HOLOBFIM_01502	3.91e-292	yhdG	-	-	E	ko:K03294	-	ko00000	Amino Acid
HOLOBFIM_01503	4.28e-181	yejC	-	-	S	-	-	-	Protein of unknown function (DUF1003)
HOLOBFIM_01504	0.0	mdlB	-	-	V	ko:K06147,ko:K18890	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_01505	0.0	mdlA	-	-	V	ko:K06148,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_01506	1.39e-40	yneF	-	-	S	ko:K09976	-	ko00000	UPF0154 protein
HOLOBFIM_01507	2.84e-48	ynzC	-	-	S	-	-	-	UPF0291 protein
HOLOBFIM_01508	3.28e-28	-	-	-	-	-	-	-	-
HOLOBFIM_01509	2e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
HOLOBFIM_01510	3.56e-185	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	Belongs to the RNA methyltransferase TrmD family
HOLOBFIM_01511	1.03e-118	rimM	-	-	J	ko:K02860	-	ko00000,ko03009	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOLOBFIM_01512	1.55e-51	ylqC	-	-	S	ko:K06960	-	ko00000	Belongs to the UPF0109 family
HOLOBFIM_01513	2.97e-59	rpsP	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bS16 family
HOLOBFIM_01514	2.16e-303	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HOLOBFIM_01515	1.26e-75	ylxM	-	-	S	ko:K09787	-	ko00000	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HOLOBFIM_01516	7.91e-70	-	-	-	-	-	-	-	-
HOLOBFIM_01517	1.06e-231	ftsY	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HOLOBFIM_01518	0.0	smc	-	-	D	ko:K03529	-	ko00000,ko03036	Required for chromosome condensation and partitioning
HOLOBFIM_01519	8.02e-161	rnc	3.1.26.3	-	J	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
HOLOBFIM_01520	0.0	oppA1	-	-	E	ko:K02035	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HOLOBFIM_01521	1.16e-193	oppC	-	-	EP	ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_01522	3.2e-216	oppB	-	-	P	ko:K02033,ko:K02034	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01523	1.62e-228	oppF	-	-	P	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_01524	4.24e-247	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_01525	3.21e-49	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOLOBFIM_01526	5.5e-239	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
HOLOBFIM_01527	0.0	recG	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HOLOBFIM_01528	0.0	yloV	-	-	S	ko:K07030	-	ko00000	DAK2 domain fusion protein YloV
HOLOBFIM_01529	5.83e-75	yloU	-	-	S	-	-	-	Asp23 family, cell envelope-related function
HOLOBFIM_01530	2.29e-36	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL28 family
HOLOBFIM_01531	3.72e-166	thiN	2.7.6.2	-	H	ko:K00949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	thiamine pyrophosphokinase
HOLOBFIM_01532	2.41e-150	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HOLOBFIM_01533	1.38e-221	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
HOLOBFIM_01534	0.0	prkC	2.7.11.1	-	KLT	ko:K08884,ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
HOLOBFIM_01535	5.22e-174	stp	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	phosphatase
HOLOBFIM_01536	0.0	sun	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HOLOBFIM_01537	3.95e-225	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOLOBFIM_01538	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HOLOBFIM_01539	5.63e-275	coaBC	4.1.1.36, 6.3.2.5	-	H	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HOLOBFIM_01540	1.77e-47	rpoZ	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
HOLOBFIM_01541	2.95e-147	gmk	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Essential for recycling GMP and indirectly, cGMP
HOLOBFIM_01542	5.76e-118	-	-	-	S	ko:K07001	-	ko00000	Patatin-like phospholipase
HOLOBFIM_01543	2.71e-66	-	-	-	-	-	-	-	-
HOLOBFIM_01545	0.0	recN	-	-	L	ko:K03631	-	ko00000,ko03400	May be involved in recombinational repair of damaged DNA
HOLOBFIM_01546	2.42e-95	argR2	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HOLOBFIM_01547	8.09e-197	rrmJ	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	Ribosomal RNA large subunit methyltransferase J
HOLOBFIM_01548	1.28e-189	ispA	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HOLOBFIM_01549	1.42e-43	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HOLOBFIM_01550	1.56e-295	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
HOLOBFIM_01551	1.05e-191	folD	1.5.1.5, 3.5.4.9	-	F	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOLOBFIM_01552	2.34e-88	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOLOBFIM_01553	9.44e-99	WQ51_04310	-	-	S	ko:K10947	-	ko00000,ko03000	Asp23 family, cell envelope-related function
HOLOBFIM_01554	6.06e-132	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOLOBFIM_01556	3.55e-258	pepP	3.4.11.9, 3.4.13.9	-	E	ko:K01262,ko:K01271	-	ko00000,ko01000,ko01002	Creatinase/Prolidase N-terminal domain
HOLOBFIM_01557	3.12e-61	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL27 family
HOLOBFIM_01558	1.77e-74	ysxB	-	-	J	ko:K07584	-	ko00000	Cysteine protease Prp
HOLOBFIM_01559	5.83e-67	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to 23S rRNA in the presence of protein L20
HOLOBFIM_01560	1.17e-16	-	-	-	-	-	-	-	-
HOLOBFIM_01563	0.0	pepX	3.4.14.11	-	E	ko:K01281	-	ko00000,ko01000,ko01002	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
HOLOBFIM_01564	0.0	glnA	6.3.1.2	-	E	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
HOLOBFIM_01565	1.32e-80	glnR	-	-	K	ko:K03713,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000,ko03000	Transcriptional regulator
HOLOBFIM_01566	0.0	speA	4.1.1.17, 4.1.1.18, 4.1.1.19	-	E	ko:K01581,ko:K01582,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Orn/Lys/Arg decarboxylase, C-terminal domain
HOLOBFIM_01567	1.65e-304	ynbB	-	-	P	-	-	-	aluminum resistance
HOLOBFIM_01568	2.57e-221	miaA	2.5.1.75	-	F	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HOLOBFIM_01569	3.33e-35	WQ51_02665	-	-	S	-	-	-	Protein of unknown function (DUF3042)
HOLOBFIM_01570	1.93e-96	yqhL	-	-	P	-	-	-	Rhodanese-like protein
HOLOBFIM_01571	1.13e-228	glcK	2.7.1.2	-	G	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Glucokinase
HOLOBFIM_01572	6.79e-55	yqgQ	-	-	S	-	-	-	Bacterial protein of unknown function (DUF910)
HOLOBFIM_01573	5.43e-157	gluP	3.4.21.105	-	S	ko:K19225	-	ko00000,ko01000,ko01002	Peptidase, S54 family
HOLOBFIM_01574	0.0	pbp2b	-	-	M	ko:K00687,ko:K12553,ko:K21465,ko:K21466	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein
HOLOBFIM_01575	0.0	-	-	-	S	-	-	-	Bacterial membrane protein YfhO
HOLOBFIM_01576	6.83e-69	yneR	-	-	S	-	-	-	Belongs to the HesB IscA family
HOLOBFIM_01577	8.32e-149	vraR	-	-	K	ko:K07694,ko:K11618	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	helix_turn_helix, Lux Regulon
HOLOBFIM_01578	1.81e-229	vraS	2.7.13.3	-	T	ko:K07681,ko:K11617	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HOLOBFIM_01579	1.82e-163	yvqF	-	-	S	ko:K11622	ko02020,map02020	ko00000,ko00001	Cell wall-active antibiotics response 4TMS YvqF
HOLOBFIM_01580	1.05e-101	greA	-	-	K	ko:K03624	-	ko00000,ko03021	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
HOLOBFIM_01581	3.43e-148	udk	2.7.1.48	-	F	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko01000	Cytidine monophosphokinase
HOLOBFIM_01582	4.99e-263	mltG	-	-	S	ko:K07082	-	ko00000	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOLOBFIM_01583	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HOLOBFIM_01584	3.55e-259	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HOLOBFIM_01585	1.2e-87	yodB	-	-	K	-	-	-	Transcriptional regulator, HxlR family
HOLOBFIM_01586	3.09e-122	XK27_09705	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HOLOBFIM_01587	9.01e-178	spoU	-	-	J	ko:K03437	-	ko00000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOLOBFIM_01588	4.17e-60	acyP	3.6.1.7	-	C	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	ko00000,ko00001,ko01000	Belongs to the acylphosphatase family
HOLOBFIM_01589	2.58e-228	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HOLOBFIM_01590	0.0	arlS	2.7.13.3	-	T	ko:K18940	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HOLOBFIM_01591	1.01e-157	csrR	-	-	K	-	-	-	response regulator
HOLOBFIM_01592	0.0	gnd	1.1.1.343, 1.1.1.44	-	H	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HOLOBFIM_01593	6.97e-53	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
HOLOBFIM_01594	1.09e-127	ylbN	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
HOLOBFIM_01595	3.92e-269	ylbM	-	-	S	-	-	-	Belongs to the UPF0348 family
HOLOBFIM_01596	4.66e-176	yccK	-	-	Q	-	-	-	ubiE/COQ5 methyltransferase family
HOLOBFIM_01597	1.18e-78	rsfS	-	-	J	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
HOLOBFIM_01598	3.21e-142	yqeK	-	-	H	-	-	-	Hydrolase, HD family
HOLOBFIM_01599	2.72e-157	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOLOBFIM_01600	3.95e-65	yhbY	-	-	J	ko:K07574	-	ko00000,ko03009	RNA-binding protein
HOLOBFIM_01601	1.43e-260	yqeH	-	-	S	ko:K06948	-	ko00000,ko03009	Ribosome biogenesis GTPase YqeH
HOLOBFIM_01602	6.63e-127	yqeG	-	-	S	ko:K07015	-	ko00000	HAD phosphatase, family IIIA
HOLOBFIM_01603	1.13e-219	ykcA	-	-	E	-	-	-	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HOLOBFIM_01604	1.12e-242	mhqA_2	-	-	E	ko:K15975	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HOLOBFIM_01605	2.14e-157	mhqD	-	-	S	ko:K06999	-	ko00000	Dienelactone hydrolase family
HOLOBFIM_01606	4.31e-231	-	-	-	C	-	-	-	Alcohol dehydrogenase GroES-like domain
HOLOBFIM_01607	1.17e-129	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Belongs to the LOG family
HOLOBFIM_01608	1.02e-74	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HOLOBFIM_01609	1.13e-36	rpmI	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL35 family
HOLOBFIM_01610	7.46e-101	infC	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HOLOBFIM_01611	2.31e-165	-	-	-	S	-	-	-	SseB protein N-terminal domain
HOLOBFIM_01612	5.3e-70	-	-	-	-	-	-	-	-
HOLOBFIM_01613	4.97e-132	yrgI	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Histidine phosphatase superfamily (branch 1)
HOLOBFIM_01614	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOLOBFIM_01616	1.02e-180	dnaI	-	-	L	ko:K11144	-	ko00000,ko03032	Primosomal protein DnaI
HOLOBFIM_01617	1.04e-303	dnaB	-	-	L	ko:K03346	-	ko00000,ko03032	replication initiation and membrane attachment
HOLOBFIM_01618	4.15e-103	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOLOBFIM_01619	4.68e-131	coaE	2.7.1.24	-	F	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HOLOBFIM_01620	2.52e-203	fpg	3.2.2.23, 4.2.99.18	-	L	ko:K10563	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
HOLOBFIM_01621	0.0	polA	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOLOBFIM_01622	4.93e-153	ybhL	-	-	S	ko:K06890	-	ko00000	Inhibitor of apoptosis-promoting Bax1
HOLOBFIM_01623	0.0	murC	6.3.2.8	-	M	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Belongs to the MurCDEF family
HOLOBFIM_01624	0.0	sftA	-	-	D	ko:K03466	-	ko00000,ko03036	Belongs to the FtsK SpoIIIE SftA family
HOLOBFIM_01625	3.17e-149	XK27_10290	-	-	J	ko:K06878	-	ko00000	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
HOLOBFIM_01626	5.32e-73	ytpP	-	-	CO	-	-	-	Thioredoxin
HOLOBFIM_01627	5.99e-06	-	-	-	S	-	-	-	Small secreted protein
HOLOBFIM_01628	8.13e-157	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
HOLOBFIM_01629	1.51e-187	ytmP	-	-	M	-	-	-	Choline/ethanolamine kinase
HOLOBFIM_01630	2.38e-274	ecsB	-	-	U	ko:K01992	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_01631	2.4e-172	ecsA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01632	1.67e-99	hit	-	-	FG	ko:K02503	-	ko00000,ko04147	histidine triad
HOLOBFIM_01633	5.77e-81	-	-	-	S	-	-	-	YtxH-like protein
HOLOBFIM_01634	5.26e-205	prsA	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HOLOBFIM_01635	8.42e-232	yhaM	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
HOLOBFIM_01636	1.03e-72	-	-	-	S	-	-	-	Control of competence regulator ComK, YlbF/YmcA
HOLOBFIM_01637	0.0	pbp2A	2.4.1.129, 3.4.16.4	GT51	M	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	penicillin-binding protein
HOLOBFIM_01638	8.75e-197	rluA	5.4.99.23, 5.4.99.28, 5.4.99.29	-	J	ko:K06177,ko:K06180	-	ko00000,ko01000,ko03009,ko03016	Responsible for synthesis of pseudouridine from uracil
HOLOBFIM_01639	3.31e-98	argR1	-	-	K	ko:K03402	-	ko00000,ko03000	Regulates arginine biosynthesis genes
HOLOBFIM_01640	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl-tRNA synthetase
HOLOBFIM_01642	1.97e-88	-	-	-	-	-	-	-	-
HOLOBFIM_01643	1.93e-30	-	-	-	-	-	-	-	-
HOLOBFIM_01644	2.12e-226	pyrD	1.3.5.2, 1.3.98.1	-	F	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of dihydroorotate to orotate
HOLOBFIM_01645	9.29e-294	glpQ4	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	phosphodiesterase
HOLOBFIM_01646	1.31e-98	glpQ4	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	phosphodiesterase
HOLOBFIM_01647	1.44e-157	mecA	-	-	NOT	ko:K16511	-	ko00000	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HOLOBFIM_01648	1.13e-89	spxA	-	-	K	ko:K16509	-	ko00000	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress
HOLOBFIM_01649	3.28e-176	yhfI	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
HOLOBFIM_01650	7.88e-121	traP	1.14.99.57, 6.2.1.3	-	S	ko:K01897,ko:K21481	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	heme oxygenase (decyclizing) activity
HOLOBFIM_01651	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter (permease)
HOLOBFIM_01652	1.14e-177	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_01653	1.57e-159	rrp1	-	-	K	ko:K02483	-	ko00000,ko02022	response regulator
HOLOBFIM_01654	9.13e-262	-	-	-	T	ko:K19168	-	ko00000,ko02048	His Kinase A (phosphoacceptor) domain
HOLOBFIM_01655	1.54e-141	nrdG	1.97.1.4	-	O	ko:K04068	-	ko00000,ko01000	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOLOBFIM_01656	0.0	copB	3.6.3.3, 3.6.3.4, 3.6.3.5	-	P	ko:K01533,ko:K01534	-	ko00000,ko01000	P-type ATPase
HOLOBFIM_01657	1.17e-100	copR	-	-	K	ko:K02171	ko01501,map01501	ko00000,ko00001,ko00002,ko01504,ko03000	Copper transport repressor CopY TcrY
HOLOBFIM_01658	1.06e-297	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the GARS family
HOLOBFIM_01659	0.0	purH	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	Bifunctional purine biosynthesis protein PurH
HOLOBFIM_01660	5.35e-127	purN	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HOLOBFIM_01661	1.63e-233	purM	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylformylglycinamidine cyclo-ligase
HOLOBFIM_01662	0.0	purF	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HOLOBFIM_01663	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOLOBFIM_01664	2.06e-166	purQ	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOLOBFIM_01665	8.48e-55	purS	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOLOBFIM_01666	1.9e-171	purC	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the SAICAR synthetase family
HOLOBFIM_01667	2.03e-272	purK	6.3.4.18	-	F	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HOLOBFIM_01668	2.66e-102	purE	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HOLOBFIM_01669	2.24e-134	thiT	-	-	S	ko:K16789	-	ko00000,ko02000	Thiamine transporter protein (Thia_YuaJ)
HOLOBFIM_01670	0.0	iolT	-	-	EGP	ko:K06609	-	ko00000,ko02000	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family
HOLOBFIM_01671	0.0	ptsI	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOLOBFIM_01672	1.02e-51	ptsH	-	-	G	ko:K11189	-	ko00000,ko02000	phosphocarrier protein HPR
HOLOBFIM_01673	3.88e-38	-	-	-	-	-	-	-	-
HOLOBFIM_01674	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	Belongs to the ClpA ClpB family
HOLOBFIM_01675	3.36e-61	XK27_09445	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HOLOBFIM_01677	0.0	prfC	-	-	J	ko:K02837	-	ko00000,ko03012	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HOLOBFIM_01678	1.44e-311	hlyX	-	-	S	ko:K03699	-	ko00000,ko02042	Transporter associated domain
HOLOBFIM_01679	4.17e-262	yueF	-	-	S	-	-	-	AI-2E family transporter
HOLOBFIM_01680	4.61e-97	yjcF	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01681	1.58e-122	-	-	-	-	-	-	-	-
HOLOBFIM_01682	1.1e-134	ygaC	-	-	J	ko:K07586	-	ko00000	Belongs to the UPF0374 family
HOLOBFIM_01683	3.96e-182	recX	-	-	S	ko:K03565	-	ko00000,ko03400	Regulatory protein RecX
HOLOBFIM_01684	0.0	frvR	-	-	K	ko:K02538,ko:K03483,ko:K09685,ko:K18531	-	ko00000,ko03000	transcriptional antiterminator
HOLOBFIM_01685	1.85e-82	-	-	-	-	-	-	-	-
HOLOBFIM_01686	0.0	rumA_1	2.1.1.190, 2.1.1.35	-	J	ko:K00557,ko:K03215	-	ko00000,ko01000,ko03009,ko03016	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOLOBFIM_01687	1.97e-102	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
HOLOBFIM_01688	2.13e-172	-	-	-	K	ko:K03489	-	ko00000,ko03000	UTRA
HOLOBFIM_01689	0.0	bglA	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HOLOBFIM_01690	0.0	celD	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_01691	2.36e-111	-	-	-	-	-	-	-	-
HOLOBFIM_01692	7.89e-66	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HOLOBFIM_01693	6.27e-67	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_01694	0.0	poxL	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HOLOBFIM_01695	1.44e-276	mvaS	2.3.3.10	-	I	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Hydroxymethylglutaryl-CoA synthase
HOLOBFIM_01696	1.28e-264	mvaA	1.1.1.88, 2.3.1.9	-	C	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the HMG-CoA reductase family
HOLOBFIM_01697	4.04e-265	atoB	1.1.1.88, 2.3.1.9	-	I	ko:K00054,ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the thiolase family
HOLOBFIM_01698	7.23e-66	-	-	-	-	-	-	-	-
HOLOBFIM_01699	1.65e-205	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
HOLOBFIM_01700	3e-132	-	-	-	V	ko:K07448	-	ko00000,ko02048	Restriction endonuclease
HOLOBFIM_01701	2.25e-201	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	converts alpha-aldose to the beta-anomer
HOLOBFIM_01702	1.27e-270	-	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	succinyl-diaminopimelate desuccinylase
HOLOBFIM_01703	4.33e-132	-	-	-	S	-	-	-	ECF transporter, substrate-specific component
HOLOBFIM_01705	1.4e-105	-	-	-	K	-	-	-	Acetyltransferase GNAT Family
HOLOBFIM_01706	2.74e-110	ydcK	-	-	S	ko:K03095	-	ko00000	Belongs to the SprT family
HOLOBFIM_01707	2.36e-167	XK27_08845	-	-	S	ko:K05833	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01708	3.3e-187	XK27_08840	-	-	U	ko:K05832	-	ko00000,ko00002,ko02000	Belongs to the binding-protein-dependent transport system permease family
HOLOBFIM_01709	1.43e-197	XK27_08835	-	-	S	ko:K01989	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_01710	1.17e-95	-	-	-	-	-	-	-	-
HOLOBFIM_01711	0.0	pacL	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HOLOBFIM_01712	4.84e-278	-	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_01713	2.51e-195	nadE	6.3.1.5	-	F	ko:K01916	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
HOLOBFIM_01714	1.11e-280	-	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_01715	0.0	pncB	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HOLOBFIM_01716	1.62e-161	yvoA_2	-	-	K	ko:K03710	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
HOLOBFIM_01717	7.45e-280	nagA	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HOLOBFIM_01718	2.27e-177	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOLOBFIM_01719	0.0	yuxL	3.4.19.1	-	E	ko:K01303	-	ko00000,ko01000,ko01002	Prolyl oligopeptidase family
HOLOBFIM_01722	1.41e-201	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HOLOBFIM_01723	0.0	dtpT	-	-	U	ko:K03305	-	ko00000	amino acid peptide transporter
HOLOBFIM_01724	0.0	-	-	-	V	ko:K02003,ko:K02004	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01725	1.71e-87	-	-	-	-	-	-	-	-
HOLOBFIM_01726	6.13e-100	-	-	-	S	-	-	-	function, without similarity to other proteins
HOLOBFIM_01727	0.0	-	-	-	G	-	-	-	MFS/sugar transport protein
HOLOBFIM_01728	9.2e-293	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
HOLOBFIM_01729	8.15e-77	-	-	-	-	-	-	-	-
HOLOBFIM_01730	0.0	pckA	4.1.1.49	-	C	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Phosphoenolpyruvate carboxykinase
HOLOBFIM_01731	6.28e-25	-	-	-	S	-	-	-	Virus attachment protein p12 family
HOLOBFIM_01732	0.0	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
HOLOBFIM_01733	4.14e-91	-	-	-	P	ko:K04758	-	ko00000,ko02000	FeoA
HOLOBFIM_01734	2.02e-168	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
HOLOBFIM_01736	2.17e-279	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HOLOBFIM_01737	3.29e-83	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
HOLOBFIM_01738	8.49e-56	-	-	-	-	-	-	-	-
HOLOBFIM_01741	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_01742	1.88e-239	-	-	-	S	-	-	-	Phage tail protein
HOLOBFIM_01743	0.0	-	-	-	L	-	-	-	Phage tail tape measure protein TP901
HOLOBFIM_01744	2.41e-29	-	-	-	S	-	-	-	Phage tail assembly chaperone proteins, TAC
HOLOBFIM_01745	5.04e-131	-	-	-	S	-	-	-	Phage tail tube protein
HOLOBFIM_01746	1.86e-77	-	-	-	S	-	-	-	Protein of unknown function (DUF806)
HOLOBFIM_01747	9.06e-88	-	-	-	S	-	-	-	exonuclease activity
HOLOBFIM_01748	3.23e-68	-	-	-	S	-	-	-	Phage head-tail joining protein
HOLOBFIM_01750	1.13e-139	-	-	-	S	-	-	-	Phage capsid family
HOLOBFIM_01751	1.3e-78	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S14 family
HOLOBFIM_01752	1.23e-122	-	-	-	S	-	-	-	Phage portal protein
HOLOBFIM_01754	0.0	-	-	-	S	-	-	-	Phage Terminase
HOLOBFIM_01755	1.44e-49	-	-	-	L	-	-	-	Phage terminase, small subunit
HOLOBFIM_01756	1.26e-44	-	-	-	L	-	-	-	HNH nucleases
HOLOBFIM_01759	4.71e-54	-	-	-	-	-	-	-	-
HOLOBFIM_01760	7.05e-65	-	-	-	-	-	-	-	-
HOLOBFIM_01761	2.48e-276	-	-	-	S	-	-	-	GcrA cell cycle regulator
HOLOBFIM_01764	8.98e-16	-	-	-	-	-	-	-	-
HOLOBFIM_01766	6.09e-92	-	-	-	-	-	-	-	-
HOLOBFIM_01772	2.82e-196	pi346	-	-	L	ko:K02315	-	ko00000,ko03032	IstB-like ATP binding protein
HOLOBFIM_01773	3.25e-128	-	-	-	L	-	-	-	Helix-turn-helix domain
HOLOBFIM_01777	1.21e-06	-	-	-	S	-	-	-	Domain of unknown function (DUF771)
HOLOBFIM_01778	4.61e-57	-	-	-	S	-	-	-	Domain of unknown function (DUF1883)
HOLOBFIM_01779	1.76e-116	-	-	-	-	-	-	-	-
HOLOBFIM_01781	1.55e-170	-	-	-	S	-	-	-	ORF6N domain
HOLOBFIM_01785	9.08e-71	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_01786	6.75e-92	-	-	-	E	-	-	-	Zn peptidase
HOLOBFIM_01787	1.24e-139	-	-	-	P	ko:K10716	-	ko00000,ko02000	Ion transport protein
HOLOBFIM_01790	1.48e-27	-	-	-	-	-	-	-	-
HOLOBFIM_01791	6.33e-17	-	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HOLOBFIM_01793	1.02e-224	int3	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HOLOBFIM_01796	4.34e-151	-	-	-	S	ko:K07118	-	ko00000	NAD(P)H-binding
HOLOBFIM_01797	8.14e-79	-	-	-	S	-	-	-	MucBP domain
HOLOBFIM_01798	9.73e-109	-	-	-	-	-	-	-	-
HOLOBFIM_01801	5.19e-90	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HOLOBFIM_01804	1.45e-46	-	-	-	-	-	-	-	-
HOLOBFIM_01805	1.89e-294	serS	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOLOBFIM_01806	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HOLOBFIM_01807	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HOLOBFIM_01808	0.0	lysP	-	-	E	ko:K03293,ko:K11733	-	ko00000,ko02000	amino acid
HOLOBFIM_01810	2.4e-169	budA	4.1.1.5	-	Q	ko:K01575	ko00650,ko00660,map00650,map00660	ko00000,ko00001,ko01000	Alpha-acetolactate decarboxylase
HOLOBFIM_01811	0.0	alsS	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the TPP enzyme family
HOLOBFIM_01812	4.81e-127	-	-	-	-	-	-	-	-
HOLOBFIM_01813	8.44e-128	yjcK	2.3.1.128	-	J	ko:K03790	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HOLOBFIM_01814	1.12e-244	-	-	-	S	-	-	-	Protein of unknown function C-terminal (DUF3324)
HOLOBFIM_01815	3.26e-113	-	-	-	-	-	-	-	-
HOLOBFIM_01816	1.43e-25	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL33 family
HOLOBFIM_01817	3.46e-149	sodA	1.15.1.1	-	C	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HOLOBFIM_01818	1.73e-202	yjbO	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
HOLOBFIM_01819	1.25e-201	-	-	-	I	-	-	-	alpha/beta hydrolase fold
HOLOBFIM_01820	4.56e-41	-	-	-	-	-	-	-	-
HOLOBFIM_01821	2.13e-96	-	-	-	-	-	-	-	-
HOLOBFIM_01822	1.63e-198	citG	2.4.2.52	-	H	ko:K05966	ko02020,map02020	ko00000,ko00001,ko01000	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
HOLOBFIM_01823	4.14e-163	citR	-	-	K	-	-	-	FCD
HOLOBFIM_01824	0.0	oadA	4.1.1.3	-	C	ko:K01571	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Conserved carboxylase domain
HOLOBFIM_01825	4.76e-119	citX	2.7.7.61	-	HI	ko:K05964	ko02020,map02020	ko00000,ko00001,ko01000	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HOLOBFIM_01826	0.0	citF	2.8.3.10	-	H	ko:K01643	ko02020,map02020	ko00000,ko00001,ko01000	Citrate (pro-3S)-lyase alpha chain
HOLOBFIM_01827	7.46e-201	citE	4.1.3.34	-	G	ko:K01644	ko02020,map02020	ko00000,ko00001,ko01000	Belongs to the HpcH HpaI aldolase family
HOLOBFIM_01828	3.41e-65	citD	-	-	C	ko:K01646	ko02020,map02020	ko00000,ko00001	Covalent carrier of the coenzyme of citrate lyase
HOLOBFIM_01829	5.81e-226	citC	6.2.1.22	-	H	ko:K01910	ko02020,map02020	ko00000,ko00001,ko01000	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HOLOBFIM_01830	3.26e-07	-	-	-	-	-	-	-	-
HOLOBFIM_01831	1.13e-250	oadB	4.1.1.3	-	C	ko:K01572	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Na+-transporting oxaloacetate decarboxylase beta subunit
HOLOBFIM_01832	3.45e-62	oadG	-	-	I	-	-	-	Biotin-requiring enzyme
HOLOBFIM_01833	3.17e-71	-	-	-	-	-	-	-	-
HOLOBFIM_01834	4.1e-307	citM	-	-	C	ko:K03300	-	ko00000	Citrate transporter
HOLOBFIM_01835	3.61e-55	-	-	-	-	-	-	-	-
HOLOBFIM_01836	5.19e-133	kptA	-	-	J	ko:K07559	-	ko00000,ko01000,ko03016	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HOLOBFIM_01837	3.76e-108	-	-	-	K	-	-	-	GNAT family
HOLOBFIM_01838	6.38e-136	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	NADP oxidoreductase coenzyme F420-dependent
HOLOBFIM_01839	1.13e-75	padR	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HOLOBFIM_01840	5.7e-112	ORF00048	-	-	-	-	-	-	-
HOLOBFIM_01841	7.41e-176	nfrA	1.5.1.38	-	C	ko:K19285	ko00740,ko01100,map00740,map01100	ko00000,ko00001,ko01000	nitroreductase
HOLOBFIM_01842	3.34e-215	ybhF_1	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_01843	0.0	-	-	-	M	ko:K01992	-	ko00000,ko00002,ko02000	Exporter of polyketide antibiotics
HOLOBFIM_01844	9.83e-148	-	-	-	K	ko:K09017	-	ko00000,ko03000	Transcriptional regulator
HOLOBFIM_01845	0.0	-	-	-	EGP	-	-	-	Major Facilitator
HOLOBFIM_01846	1.65e-160	-	-	-	S	ko:K07090	-	ko00000	membrane transporter protein
HOLOBFIM_01847	1.06e-233	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_01848	4.73e-209	-	-	-	S	-	-	-	Alpha beta hydrolase
HOLOBFIM_01849	8.13e-82	lexA	-	-	K	ko:K07979	-	ko00000,ko03000	Transcriptional regulator, GntR family
HOLOBFIM_01850	1.6e-161	yhcG	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_01851	1.32e-15	-	-	-	-	-	-	-	-
HOLOBFIM_01852	5.01e-129	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HOLOBFIM_01853	8.12e-205	-	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
HOLOBFIM_01854	1.69e-255	-	-	-	P	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
HOLOBFIM_01856	6.82e-226	-	-	-	EP	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOLOBFIM_01857	1.71e-214	-	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_01858	0.0	-	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
HOLOBFIM_01859	2.7e-161	-	-	-	S	-	-	-	DJ-1/PfpI family
HOLOBFIM_01860	2.12e-70	-	-	-	K	-	-	-	Transcriptional
HOLOBFIM_01861	1.07e-48	-	-	-	-	-	-	-	-
HOLOBFIM_01862	0.0	-	-	-	V	-	-	-	ABC transporter transmembrane region
HOLOBFIM_01863	0.0	-	-	-	V	ko:K06147,ko:K06148,ko:K11085,ko:K18889	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter transmembrane region
HOLOBFIM_01865	3.24e-89	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HOLOBFIM_01866	7.96e-20	-	2.7.1.39	-	S	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Phosphotransferase enzyme family
HOLOBFIM_01867	0.0	-	-	-	M	-	-	-	LysM domain
HOLOBFIM_01868	1.95e-172	zmp3	-	-	O	-	-	-	Zinc-dependent metalloprotease
HOLOBFIM_01869	5.59e-173	-	-	-	K	-	-	-	DeoR C terminal sensor domain
HOLOBFIM_01871	1.39e-123	yjdB	-	-	S	-	-	-	Domain of unknown function (DUF4767)
HOLOBFIM_01874	3.15e-112	-	-	-	K	-	-	-	IrrE N-terminal-like domain
HOLOBFIM_01876	0.0	guaA	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the synthesis of GMP from XMP
HOLOBFIM_01877	8.03e-229	coaA	2.7.1.33	-	F	ko:K00867	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Pantothenic acid kinase
HOLOBFIM_01879	1.13e-54	-	-	-	-	-	-	-	-
HOLOBFIM_01880	0.0	pepDA	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HOLOBFIM_01881	1.68e-108	ykhA	3.1.2.20	-	I	ko:K01073	-	ko00000,ko01000	Thioesterase superfamily
HOLOBFIM_01882	0.0	helD	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	DNA helicase
HOLOBFIM_01884	2.14e-29	-	-	-	-	-	-	-	-
HOLOBFIM_01885	0.0	yjbQ	-	-	P	ko:K03455,ko:K03499	-	ko00000,ko02000	TrkA C-terminal domain protein
HOLOBFIM_01886	1.97e-230	pepR	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HOLOBFIM_01887	2.61e-105	yjhE	-	-	S	-	-	-	Phage tail protein
HOLOBFIM_01888	1.55e-307	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HOLOBFIM_01889	2.73e-238	hemH	4.99.1.1, 4.99.1.9	-	H	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the ferrous insertion into protoporphyrin IX
HOLOBFIM_01890	4.03e-164	gpm2	-	-	G	-	-	-	Phosphoglycerate mutase family
HOLOBFIM_01891	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HOLOBFIM_01892	2.68e-174	cysA	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01893	0.0	-	-	-	E	-	-	-	Amino Acid
HOLOBFIM_01894	2.01e-210	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HOLOBFIM_01895	4.57e-304	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HOLOBFIM_01896	5.05e-167	nodB3	-	-	G	-	-	-	Polysaccharide deacetylase
HOLOBFIM_01897	2.73e-34	-	-	-	S	-	-	-	Acyltransferase family
HOLOBFIM_01898	5.76e-60	-	-	-	M	-	-	-	NLP P60 protein
HOLOBFIM_01899	1.37e-138	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HOLOBFIM_01900	1.43e-73	-	-	-	M	-	-	-	O-Antigen ligase
HOLOBFIM_01901	4.05e-98	-	-	-	M	-	-	-	Glycosyl transferases group 1
HOLOBFIM_01902	1.23e-185	cps2I	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HOLOBFIM_01903	3.16e-123	-	-	-	M	-	-	-	group 2 family protein
HOLOBFIM_01904	1.06e-154	-	4.2.1.46	-	GM	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Male sterility protein
HOLOBFIM_01905	6.19e-132	-	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
HOLOBFIM_01906	5.14e-147	licD3	-	-	M	ko:K07271	-	ko00000,ko01000	LicD family
HOLOBFIM_01907	7.04e-106	wcaA	-	-	M	-	-	-	Glycosyl transferase family 2
HOLOBFIM_01908	2.37e-250	cps2E	-	-	M	-	-	-	Bacterial sugar transferase
HOLOBFIM_01910	8.61e-72	-	-	-	S	-	-	-	ErfK ybiS ycfS ynhG family protein
HOLOBFIM_01911	1.22e-64	-	-	-	-	-	-	-	-
HOLOBFIM_01912	3.77e-12	-	-	-	I	-	-	-	Acyltransferase family
HOLOBFIM_01913	6.49e-124	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOLOBFIM_01914	1.8e-110	-	-	-	S	-	-	-	Bacterial membrane protein, YfhO
HOLOBFIM_01915	1.58e-125	-	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_01916	1.45e-190	cps2D	5.1.3.2, 5.1.3.25	-	M	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
HOLOBFIM_01917	6.51e-141	glnP	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01918	1.44e-141	glnM	-	-	P	ko:K10040	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_01919	2.05e-189	glnH	-	-	ET	ko:K10039	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter substrate-binding protein
HOLOBFIM_01920	6.35e-174	glnQ	-	-	E	ko:K10041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_01921	1.89e-228	-	-	-	-	-	-	-	-
HOLOBFIM_01923	3.91e-109	zur	-	-	P	ko:K02076,ko:K03711	-	ko00000,ko03000	Belongs to the Fur family
HOLOBFIM_01924	9.35e-15	-	-	-	-	-	-	-	-
HOLOBFIM_01925	7.28e-144	gmk2	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase
HOLOBFIM_01926	9.94e-90	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_01927	2.08e-187	spl	-	-	M	ko:K21471	-	ko00000,ko01000,ko01002,ko01011	NlpC/P60 family
HOLOBFIM_01928	1.55e-312	tyrS	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOLOBFIM_01929	1.32e-221	yeaB	-	-	P	-	-	-	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HOLOBFIM_01930	5.83e-73	-	-	-	K	-	-	-	helix_turn_helix, Arsenical Resistance Operon Repressor
HOLOBFIM_01931	1.27e-221	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HOLOBFIM_01932	0.0	malZ	3.2.1.20, 3.2.1.41	CBM48,GH13,GH31	G	ko:K01187,ko:K01200	ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 13 family
HOLOBFIM_01933	0.0	glgP	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
HOLOBFIM_01934	0.0	glgA	2.4.1.21	GT5	F	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000,ko01003	Synthesizes alpha-1,4-glucan chains using ADP-glucose
HOLOBFIM_01935	1.39e-279	glgD	2.7.7.27	-	G	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
HOLOBFIM_01936	1.18e-255	glgC	2.7.7.27	-	H	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	ko00000,ko00001,ko00002,ko01000	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HOLOBFIM_01937	0.0	glgB	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HOLOBFIM_01938	8.73e-262	ilvE	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Branched-chain amino acid aminotransferase
HOLOBFIM_01939	6.74e-134	-	-	-	M	-	-	-	Sortase family
HOLOBFIM_01940	9.32e-187	-	-	-	S	-	-	-	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOLOBFIM_01941	0.0	fbp	3.1.3.11	-	G	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	phosphatase activity
HOLOBFIM_01942	1.94e-86	spx2	-	-	P	ko:K16509	-	ko00000	ArsC family
HOLOBFIM_01943	0.0	clpE	-	-	O	ko:K03697,ko:K04086	-	ko00000,ko03110	associated with various cellular activities
HOLOBFIM_01944	7.54e-204	rfbD	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
HOLOBFIM_01945	2.05e-259	rfbB	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
HOLOBFIM_01946	7.36e-139	rfbC	5.1.3.13	-	M	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
HOLOBFIM_01947	1.71e-205	rfbA	2.7.7.24	-	H	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HOLOBFIM_01948	3.29e-185	ywqE	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	PHP domain protein
HOLOBFIM_01949	3.07e-189	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HOLOBFIM_01950	1.44e-48	tnpA1	-	-	L	-	-	-	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein
HOLOBFIM_01951	2.23e-203	-	-	-	L	-	-	-	Transposase DDE domain
HOLOBFIM_01952	2.52e-236	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_01953	2.62e-97	rfbP	-	-	M	ko:K13012,ko:K19428	-	ko00000,ko01000,ko01005	Bacterial sugar transferase
HOLOBFIM_01954	3.9e-23	-	-	-	M	-	-	-	Glycosyltransferase like family 2
HOLOBFIM_01955	2.41e-74	wefC	-	-	M	-	-	-	Stealth protein CR2, conserved region 2
HOLOBFIM_01956	1.16e-28	rfbF	-	GT2	V	ko:K12990	ko02024,ko02025,map02024,map02025	ko00000,ko00001,ko01000,ko01003,ko01005	Glycosyl transferase, family 2
HOLOBFIM_01957	2.97e-127	cps2I	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
HOLOBFIM_01958	9.98e-50	cps1B	-	GT2,GT4	M	ko:K20444	-	ko00000,ko01000,ko01005,ko02000	transferase activity, transferring glycosyl groups
HOLOBFIM_01960	1.3e-37	-	-	-	M	-	-	-	Glycosyl transferases group 1
HOLOBFIM_01961	4.89e-39	-	-	-	S	-	-	-	Glycosyl transferase family 2
HOLOBFIM_01962	5.55e-138	ywqD	-	-	D	-	-	-	Capsular exopolysaccharide family
HOLOBFIM_01963	1.83e-146	epsB	-	-	M	-	-	-	biosynthesis protein
HOLOBFIM_01964	1.5e-169	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
HOLOBFIM_01965	4.2e-106	ccl	-	-	S	-	-	-	QueT transporter
HOLOBFIM_01966	4.62e-163	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
HOLOBFIM_01967	2.1e-49	XK27_01315	-	-	S	-	-	-	Protein of unknown function (DUF2829)
HOLOBFIM_01968	6.56e-64	-	-	-	K	-	-	-	sequence-specific DNA binding
HOLOBFIM_01969	6.17e-151	gpm5	-	-	G	-	-	-	Phosphoglycerate mutase family
HOLOBFIM_01970	2.59e-229	oppF	-	-	P	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_01971	4.99e-251	oppD	-	-	P	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_01972	3.01e-227	oppC	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOLOBFIM_01973	1.4e-208	oppB	-	-	P	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOLOBFIM_01974	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HOLOBFIM_01975	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HOLOBFIM_01976	4.1e-130	efp	-	-	J	ko:K02356	-	ko00000,ko03012	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOLOBFIM_01977	3.29e-171	lutC	-	-	S	ko:K00782	-	ko00000	LUD domain
HOLOBFIM_01978	0.0	lutB	-	-	C	ko:K18929	-	ko00000	4Fe-4S dicluster domain
HOLOBFIM_01979	1.7e-190	lutA	-	-	C	ko:K18928	-	ko00000	Cysteine-rich domain
HOLOBFIM_01980	2.39e-109	-	-	-	-	-	-	-	-
HOLOBFIM_01981	1.09e-68	-	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase system cellobiose-specific component IIA
HOLOBFIM_01982	2.54e-268	ybhE	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HOLOBFIM_01983	1.62e-90	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HOLOBFIM_01985	0.0	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_01986	0.0	galA	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	alpha-galactosidase
HOLOBFIM_01987	7.42e-174	XK27_08125	-	-	S	ko:K09861	-	ko00000	Belongs to the UPF0246 family
HOLOBFIM_01988	2.49e-177	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2087)
HOLOBFIM_01989	0.0	-	3.1.11.5	-	L	ko:K03581	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Helix-hairpin-helix containing domain
HOLOBFIM_01990	3.57e-102	-	-	-	-	-	-	-	-
HOLOBFIM_01991	1.07e-75	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_01992	3.96e-185	frlD1	2.7.1.218	-	G	ko:K10710	-	ko00000,ko01000	pfkB family carbohydrate kinase
HOLOBFIM_01993	0.0	hyuA	-	-	EQ	-	-	-	Hydantoinase/oxoprolinase N-terminal region
HOLOBFIM_01994	1.52e-262	-	-	-	S	ko:K09703	-	ko00000	Protein of unknown function (DUF917)
HOLOBFIM_01995	1.14e-278	-	-	-	F	ko:K10974	-	ko00000,ko02000	Permease for cytosine/purines, uracil, thiamine, allantoin
HOLOBFIM_01996	5.3e-173	-	-	-	-	-	-	-	-
HOLOBFIM_01997	4.65e-75	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HOLOBFIM_01998	7.09e-223	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HOLOBFIM_01999	3.47e-95	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
HOLOBFIM_02000	2.24e-251	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
HOLOBFIM_02001	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
HOLOBFIM_02002	1.57e-98	-	-	-	-	-	-	-	-
HOLOBFIM_02003	7.06e-271	-	-	-	-	-	-	-	-
HOLOBFIM_02004	0.0	pts26BCA	2.7.1.211	-	G	ko:K02808,ko:K02809,ko:K02810	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_02005	0.0	malL	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HOLOBFIM_02006	1.75e-231	purR2	-	-	K	ko:K02529	-	ko00000,ko03000	Periplasmic binding proteins and sugar binding domain of LacI family
HOLOBFIM_02007	0.0	scrB	3.2.1.26	GH32	G	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	invertase
HOLOBFIM_02008	9.94e-210	-	-	-	GM	-	-	-	NmrA-like family
HOLOBFIM_02009	3.95e-297	cfa	2.1.1.79	-	M	ko:K00574	-	ko00000,ko01000	cyclopropane-fatty-acyl-phospholipid synthase
HOLOBFIM_02010	3.41e-184	accA	2.1.3.15, 6.4.1.2	-	I	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	alpha subunit
HOLOBFIM_02011	4.15e-192	accD	2.1.3.15, 6.4.1.2	-	I	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOLOBFIM_02012	0.0	accC	6.3.4.14, 6.4.1.2	-	I	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002,ko01000	Acetyl-CoA carboxylase biotin carboxylase subunit
HOLOBFIM_02013	3.23e-98	fabZ	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
HOLOBFIM_02014	8.8e-93	accB	-	-	I	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	ko00000,ko00001,ko00002	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
HOLOBFIM_02015	4.03e-283	fabF	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
HOLOBFIM_02016	8.26e-164	fabG	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	reductase
HOLOBFIM_02017	2.32e-207	fabD	2.3.1.39	-	I	ko:K00645,ko:K15327,ko:K15329	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	Malonyl CoA-acyl carrier protein transacylase
HOLOBFIM_02018	4.56e-220	fabK	1.3.1.9	-	S	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Nitronate monooxygenase
HOLOBFIM_02019	1.38e-45	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOLOBFIM_02020	5.62e-226	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOLOBFIM_02021	2.44e-99	-	-	-	K	-	-	-	Winged helix DNA-binding domain
HOLOBFIM_02022	6.79e-95	-	4.2.1.59	-	I	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	FabA-like domain
HOLOBFIM_02024	1.47e-245	-	-	-	E	-	-	-	Alpha/beta hydrolase family
HOLOBFIM_02025	5.57e-290	-	-	-	C	-	-	-	Iron-containing alcohol dehydrogenase
HOLOBFIM_02026	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_02027	2.84e-63	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2316)
HOLOBFIM_02028	2.84e-88	-	-	-	K	ko:K18909	-	ko00000,ko00002,ko01504,ko03000	MarR family
HOLOBFIM_02029	5.76e-14	tcaA	-	-	S	ko:K21463	-	ko00000	response to antibiotic
HOLOBFIM_02030	2.67e-211	-	-	-	S	-	-	-	Putative esterase
HOLOBFIM_02031	2.04e-253	-	-	-	-	-	-	-	-
HOLOBFIM_02032	7.6e-115	-	-	-	K	-	-	-	Transcriptional regulator, MarR family
HOLOBFIM_02033	0.0	lmrA	3.6.3.44	-	V	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	ABC transporter
HOLOBFIM_02034	6.6e-106	-	-	-	F	-	-	-	NUDIX domain
HOLOBFIM_02035	1.91e-167	gpmA	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HOLOBFIM_02036	9.57e-30	-	-	-	-	-	-	-	-
HOLOBFIM_02037	2.4e-200	-	-	-	S	-	-	-	zinc-ribbon domain
HOLOBFIM_02038	1.7e-261	pbpX	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_02039	4.01e-240	ydbI	-	-	K	-	-	-	AI-2E family transporter
HOLOBFIM_02040	3.54e-165	srtA	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HOLOBFIM_02041	1.41e-85	gtcA2	-	-	S	-	-	-	Teichoic acid glycosylation protein
HOLOBFIM_02042	3.1e-218	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
HOLOBFIM_02043	0.0	-	1.2.3.3	-	EH	ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Belongs to the TPP enzyme family
HOLOBFIM_02044	3.51e-216	gbuC	-	-	E	ko:K02001,ko:K02002	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HOLOBFIM_02045	5.82e-189	gbuB	-	-	E	ko:K02001	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	glycine betaine
HOLOBFIM_02046	7.54e-284	gbuA	3.6.3.32	-	E	ko:K02000	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	glycine betaine
HOLOBFIM_02047	1.39e-176	sfsA	-	-	S	ko:K06206	-	ko00000	Belongs to the SfsA family
HOLOBFIM_02048	2.6e-96	usp1	-	-	T	-	-	-	Universal stress protein family
HOLOBFIM_02049	0.0	yxbA	6.3.1.12	-	S	ko:K17810	-	ko00000,ko01000	ATP-grasp enzyme
HOLOBFIM_02050	6.35e-195	thrB	2.7.1.39	-	F	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
HOLOBFIM_02051	0.0	thrC	4.2.3.1	-	E	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Threonine synthase
HOLOBFIM_02052	1.13e-290	hom	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	homoserine dehydrogenase
HOLOBFIM_02053	0.0	-	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the aspartokinase family
HOLOBFIM_02054	1.52e-268	floL	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	SPFH domain / Band 7 family
HOLOBFIM_02055	4.4e-50	-	-	-	-	-	-	-	-
HOLOBFIM_02056	1.23e-221	pfoSR	-	-	S	ko:K07035	-	ko00000	Phosphotransferase system, EIIC
HOLOBFIM_02057	7.14e-226	ldhD	1.1.1.28	-	CH	ko:K03778	ko00620,ko01120,map00620,map01120	ko00000,ko00001,ko01000	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOLOBFIM_02058	5.66e-278	aspC	2.6.1.57	-	E	ko:K00832,ko:K00841	ko00270,ko00300,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase
HOLOBFIM_02059	9.93e-65	-	-	-	-	-	-	-	-
HOLOBFIM_02060	2.21e-164	WQ51_05710	-	-	S	-	-	-	Mitochondrial biogenesis AIM24
HOLOBFIM_02061	1.62e-93	-	-	-	FG	ko:K02503	-	ko00000,ko04147	Scavenger mRNA decapping enzyme C-term binding
HOLOBFIM_02062	0.0	asnB	6.3.5.4	-	E	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	ko00000,ko00001,ko01000,ko01002	Asparagine synthase
HOLOBFIM_02063	1.33e-259	-	-	-	S	-	-	-	Calcineurin-like phosphoesterase
HOLOBFIM_02064	4.15e-204	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HOLOBFIM_02065	5.4e-225	hepT	2.5.1.30	-	H	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HOLOBFIM_02066	1.92e-283	ackA	2.7.2.1	-	F	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOLOBFIM_02067	9.96e-212	ysdB	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	abc transporter atp-binding protein
HOLOBFIM_02068	1.62e-234	ysdA	-	-	CP	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_02069	6.81e-86	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
HOLOBFIM_02070	9.19e-209	CcmA	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_02071	3.68e-144	-	-	-	I	-	-	-	ABC-2 family transporter protein
HOLOBFIM_02072	2.4e-186	gdh	1.1.1.47	-	IQ	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	ko00000,ko00001,ko01000	reductase
HOLOBFIM_02073	2.4e-256	ald1	1.4.1.1	-	C	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	ko00000,ko00001,ko01000	Belongs to the AlaDH PNT family
HOLOBFIM_02074	1.51e-238	ilvA	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HOLOBFIM_02075	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
HOLOBFIM_02076	8.34e-83	-	-	-	S	-	-	-	Coenzyme PQQ synthesis protein D (PqqD)
HOLOBFIM_02077	0.0	pepD3	-	-	E	ko:K08659	-	ko00000,ko01000,ko01002	Dipeptidase
HOLOBFIM_02078	0.0	gshR3	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
HOLOBFIM_02079	8.81e-316	lmrB	-	-	U	ko:K18926	-	ko00000,ko00002,ko02000	Belongs to the major facilitator superfamily
HOLOBFIM_02080	8.23e-126	-	-	-	K	ko:K18939	-	ko00000,ko00002,ko03000	Bacterial regulatory proteins, tetR family
HOLOBFIM_02081	0.0	bglH	3.2.1.86	GT1	G	ko:K01223	ko00010,ko00500,map00010,map00500	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HOLOBFIM_02082	0.0	bglP	-	-	G	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system
HOLOBFIM_02083	1.69e-198	bglG4	-	-	K	ko:K03488	-	ko00000,ko03000	CAT RNA binding domain
HOLOBFIM_02084	0.0	msbA9	-	-	V	ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HOLOBFIM_02085	0.0	cydD1	-	-	CO	ko:K06147,ko:K06148	-	ko00000,ko02000	ABC transporter transmembrane region
HOLOBFIM_02086	2.59e-97	-	-	-	S	-	-	-	NusG domain II
HOLOBFIM_02087	4.73e-209	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
HOLOBFIM_02088	1.68e-183	-	-	-	-	-	-	-	-
HOLOBFIM_02089	2.57e-193	-	-	-	S	-	-	-	Membrane
HOLOBFIM_02090	3.69e-67	-	-	-	S	-	-	-	Membrane
HOLOBFIM_02091	1.12e-82	-	-	-	S	-	-	-	Protein of unknown function (DUF1093)
HOLOBFIM_02092	1.84e-65	-	-	-	-	-	-	-	-
HOLOBFIM_02093	0.0	cydD	-	-	CO	ko:K16012	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HOLOBFIM_02094	0.0	cydC	-	-	CO	ko:K16013	ko02010,map02010	ko00000,ko00001,ko02000	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD
HOLOBFIM_02095	2.5e-233	cydB	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome d ubiquinol oxidase subunit II
HOLOBFIM_02096	0.0	cydA	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	ubiquinol oxidase
HOLOBFIM_02098	2.35e-303	pdp	2.4.2.2	-	F	ko:K00756	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	pyrimidine-nucleoside phosphorylase
HOLOBFIM_02099	3.09e-244	add	3.5.4.2, 3.5.4.4	-	F	ko:K01488,ko:K02029,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOLOBFIM_02100	6.98e-53	-	-	-	-	-	-	-	-
HOLOBFIM_02101	1.22e-112	-	-	-	-	-	-	-	-
HOLOBFIM_02102	6.71e-34	-	-	-	-	-	-	-	-
HOLOBFIM_02103	3.46e-213	-	-	-	EG	-	-	-	EamA-like transporter family
HOLOBFIM_02104	2.96e-145	tag	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	glycosylase
HOLOBFIM_02105	9.59e-101	usp5	-	-	T	-	-	-	universal stress protein
HOLOBFIM_02106	3.25e-74	-	-	-	K	-	-	-	Helix-turn-helix domain
HOLOBFIM_02107	1.29e-186	ptp3	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HOLOBFIM_02108	3.87e-286	queG	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Domain of unknown function (DUF1730)
HOLOBFIM_02109	1.54e-84	-	-	-	-	-	-	-	-
HOLOBFIM_02110	7.09e-113	bioY	-	-	S	ko:K03523	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	BioY family
HOLOBFIM_02111	5.77e-93	adhR	-	-	K	-	-	-	helix_turn_helix, mercury resistance
HOLOBFIM_02112	4.13e-34	-	-	-	C	-	-	-	Flavodoxin
HOLOBFIM_02113	3.13e-252	adh2	1.1.1.1	-	E	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	alcohol dehydrogenase
HOLOBFIM_02114	5.55e-148	-	-	-	GM	-	-	-	NmrA-like family
HOLOBFIM_02116	2.29e-131	-	-	-	Q	-	-	-	methyltransferase
HOLOBFIM_02117	8.39e-136	-	-	-	T	-	-	-	Sh3 type 3 domain protein
HOLOBFIM_02118	2.34e-152	-	-	-	F	-	-	-	glutamine amidotransferase
HOLOBFIM_02119	2.13e-173	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2263)
HOLOBFIM_02120	0.0	yhdP	-	-	S	-	-	-	Transporter associated domain
HOLOBFIM_02121	0.0	ycnB	-	-	U	-	-	-	Belongs to the major facilitator superfamily
HOLOBFIM_02122	8.38e-80	-	-	-	S	-	-	-	Domain of unknown function (DUF4811)
HOLOBFIM_02123	2.04e-129	maf	-	-	D	ko:K06287	-	ko00000	nucleoside-triphosphate diphosphatase activity
HOLOBFIM_02124	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HOLOBFIM_02125	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HOLOBFIM_02126	0.0	ydaO	-	-	E	-	-	-	amino acid
HOLOBFIM_02127	5.32e-75	-	-	-	S	-	-	-	Domain of unknown function (DUF1827)
HOLOBFIM_02128	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
HOLOBFIM_02129	1.7e-59	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HOLOBFIM_02130	6.1e-143	ydiL	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_02131	1.01e-251	brpA	-	-	K	-	-	-	Cell envelope-like function transcriptional attenuator common domain protein
HOLOBFIM_02132	3.29e-236	-	-	-	-	-	-	-	-
HOLOBFIM_02133	3.43e-203	-	-	-	V	ko:K01990,ko:K16921	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_02134	4.97e-81	ytrA	-	-	K	ko:K07979	-	ko00000,ko03000	helix_turn_helix gluconate operon transcriptional repressor
HOLOBFIM_02135	1.1e-151	rex	-	-	K	ko:K01926	-	ko00000,ko03000	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HOLOBFIM_02136	0.0	ydiF	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter, ATP-binding protein
HOLOBFIM_02137	3.12e-68	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02138	2.44e-242	tsaD	2.3.1.234	-	J	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOLOBFIM_02139	8.44e-130	rimI	2.3.1.128	-	K	ko:K03789	-	ko00000,ko01000,ko03009	Ribosomal-protein-alanine acetyltransferase
HOLOBFIM_02140	3.82e-168	yeaZ	2.3.1.234	-	O	ko:K01409,ko:K14742	-	ko00000,ko01000,ko03016	Universal bacterial protein YeaZ
HOLOBFIM_02141	1.46e-96	-	-	-	-	-	-	-	-
HOLOBFIM_02142	2.42e-117	-	-	-	T	-	-	-	ECF transporter, substrate-specific component
HOLOBFIM_02143	6.13e-232	ansB	3.5.1.1	-	EJ	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	Asparaginase
HOLOBFIM_02144	3.86e-185	fat	3.1.2.21	-	I	ko:K01071	ko00061,ko01100,map00061,map01100	ko00000,ko00001,ko01000,ko01004	Acyl-ACP thioesterase
HOLOBFIM_02145	1.74e-191	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HOLOBFIM_02146	7.92e-76	yabA	-	-	L	-	-	-	Involved in initiation control of chromosome replication
HOLOBFIM_02147	2.28e-223	holB	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III
HOLOBFIM_02148	1.14e-69	yaaQ	-	-	S	-	-	-	Cyclic-di-AMP receptor
HOLOBFIM_02149	1.45e-150	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HOLOBFIM_02150	2.95e-46	-	-	-	S	-	-	-	Protein of unknown function (DUF2508)
HOLOBFIM_02151	1.26e-139	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOLOBFIM_02152	7e-49	yaaK	-	-	S	ko:K09747	-	ko00000	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HOLOBFIM_02153	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HOLOBFIM_02154	4.38e-118	tadA	3.5.4.33	-	F	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
HOLOBFIM_02155	9.05e-67	-	-	-	-	-	-	-	-
HOLOBFIM_02156	2.35e-139	rsmC	2.1.1.172	-	J	ko:K00564	-	ko00000,ko01000,ko03009	Methyltransferase
HOLOBFIM_02157	0.0	mprF	2.3.2.3	-	S	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	ko00000,ko00001,ko00002,ko01000,ko01504	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HOLOBFIM_02158	1.15e-59	-	-	-	-	-	-	-	-
HOLOBFIM_02159	8.64e-225	ccpB	-	-	K	-	-	-	lacI family
HOLOBFIM_02160	0.0	prtB	3.4.21.96	-	O	ko:K01361	-	ko00000,ko01000,ko01002,ko03110	Belongs to the peptidase S8 family
HOLOBFIM_02161	6.92e-205	-	5.2.1.8	-	M	ko:K07533	-	ko00000,ko01000,ko03110	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins
HOLOBFIM_02162	2.21e-274	-	-	-	M	-	-	-	Glycosyl hydrolases family 25
HOLOBFIM_02163	2.07e-86	-	-	-	S	-	-	-	Bacteriophage holin of superfamily 6 (Holin_LLH)
HOLOBFIM_02165	3.47e-83	-	-	-	-	-	-	-	-
HOLOBFIM_02167	1.01e-94	-	-	-	S	-	-	-	Domain of unknown function (DUF2479)
HOLOBFIM_02168	2.19e-255	-	-	-	S	-	-	-	peptidoglycan catabolic process
HOLOBFIM_02169	8.83e-113	-	-	-	S	-	-	-	Phage tail protein
HOLOBFIM_02170	3.5e-144	-	-	-	S	-	-	-	Phage-related minor tail protein
HOLOBFIM_02173	1.75e-114	-	-	-	S	-	-	-	Phage major tail protein 2
HOLOBFIM_02175	3.45e-22	-	-	-	S	-	-	-	exonuclease activity
HOLOBFIM_02177	1.14e-41	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HOLOBFIM_02178	5.52e-187	-	-	-	-	-	-	-	-
HOLOBFIM_02179	1.94e-138	-	-	-	-	-	-	-	-
HOLOBFIM_02180	2.14e-40	-	-	-	S	-	-	-	aminoacyl-tRNA ligase activity
HOLOBFIM_02181	5.13e-35	-	-	-	-	-	-	-	-
HOLOBFIM_02184	2.9e-78	-	-	-	S	-	-	-	Phage Mu protein F like protein
HOLOBFIM_02185	1.5e-221	-	-	-	S	-	-	-	Phage portal protein, SPP1 Gp6-like
HOLOBFIM_02186	1.05e-221	-	-	-	S	-	-	-	Phage terminase large subunit
HOLOBFIM_02187	5.3e-73	-	-	-	L	ko:K07474	-	ko00000	Terminase small subunit
HOLOBFIM_02189	8.06e-280	-	-	-	S	-	-	-	GcrA cell cycle regulator
HOLOBFIM_02190	1.49e-92	-	-	-	-	-	-	-	-
HOLOBFIM_02196	2.8e-28	-	-	-	-	-	-	-	-
HOLOBFIM_02199	3.64e-40	-	-	-	S	-	-	-	Protein of unknown function (DUF1642)
HOLOBFIM_02202	1.14e-73	-	-	-	S	-	-	-	Protein of unknown function (DUF1064)
HOLOBFIM_02203	2.83e-89	-	-	-	-	-	-	-	-
HOLOBFIM_02206	1.71e-160	-	-	-	L	ko:K02315	-	ko00000,ko03032	IstB-like ATP binding protein
HOLOBFIM_02207	4.51e-63	-	-	-	L	-	-	-	Domain of unknown function (DUF4373)
HOLOBFIM_02208	1.04e-172	pi112	-	-	L	-	-	-	PDDEXK-like domain of unknown function (DUF3799)
HOLOBFIM_02209	6.58e-180	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
HOLOBFIM_02212	8.48e-22	-	-	-	-	-	-	-	-
HOLOBFIM_02216	3.67e-14	-	-	-	S	ko:K09946	-	ko00000	Domain of unknown function (DUF1508)
HOLOBFIM_02218	1.52e-09	-	-	-	K	-	-	-	sequence-specific DNA binding
HOLOBFIM_02219	2.99e-71	-	-	-	K	-	-	-	Helix-turn-helix domain
HOLOBFIM_02220	1.15e-97	-	-	-	E	-	-	-	Zn peptidase
HOLOBFIM_02221	5.11e-149	-	-	-	S	-	-	-	Domain of Unknown Function with PDB structure (DUF3862)
HOLOBFIM_02222	1.58e-126	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HOLOBFIM_02223	1.37e-74	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
HOLOBFIM_02224	7.23e-108	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOLOBFIM_02225	1.92e-283	mdtG	-	-	EGP	ko:K08161	-	ko00000,ko02000	Transporter, major facilitator family protein
HOLOBFIM_02226	1.93e-196	-	-	-	K	-	-	-	acetyltransferase
HOLOBFIM_02227	2.83e-86	-	-	-	-	-	-	-	-
HOLOBFIM_02228	3.41e-277	yceI	-	-	G	ko:K08369	-	ko00000,ko02000	Sugar (and other) transporter
HOLOBFIM_02229	0.0	gabD	1.2.1.16, 1.2.1.20, 1.2.1.79	-	C	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Belongs to the aldehyde dehydrogenase family
HOLOBFIM_02230	1.89e-158	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
HOLOBFIM_02231	6.87e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HOLOBFIM_02232	0.0	mgtA	3.6.3.2	-	P	ko:K01531	-	ko00000,ko01000	COG0474 Cation transport ATPase
HOLOBFIM_02234	2.52e-129	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
HOLOBFIM_02235	2.3e-181	nylA	3.5.1.4	-	J	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	ko00000,ko00001,ko01000	Belongs to the amidase family
HOLOBFIM_02236	2.86e-85	frataxin	-	-	S	ko:K05937	-	ko00000	Domain of unknown function (DU1801)
HOLOBFIM_02237	9.15e-122	yvqK	2.5.1.17	-	S	ko:K00798	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Cobalamin adenosyltransferase
HOLOBFIM_02238	7.87e-125	-	-	-	S	ko:K16927	-	ko00000,ko00002,ko02000	ECF transporter, substrate-specific component
HOLOBFIM_02239	1.76e-82	-	-	-	S	-	-	-	Domain of unknown function (DUF4430)
HOLOBFIM_02240	0.0	rtpR	1.17.4.2	-	F	ko:K00527	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	ribonucleoside-triphosphate reductase activity
HOLOBFIM_02241	7.61e-102	-	-	-	F	-	-	-	Nucleoside 2-deoxyribosyltransferase
HOLOBFIM_02242	9.91e-205	-	-	-	S	-	-	-	Alpha/beta hydrolase of unknown function (DUF915)
HOLOBFIM_02243	2.29e-130	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	Participates in transcription elongation, termination and antitermination
HOLOBFIM_02244	2.09e-30	secE	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
HOLOBFIM_02245	7.59e-219	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	1,4-dihydroxy-2-naphthoate
HOLOBFIM_02246	1.16e-214	menA	2.5.1.74	-	M	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
HOLOBFIM_02247	2.57e-251	apbE	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
HOLOBFIM_02248	6.86e-187	cad	-	-	S	ko:K20379	ko02024,map02024	ko00000,ko00001	FMN_bind
HOLOBFIM_02249	0.0	ndh	1.6.99.3	-	C	ko:K03885	ko00190,map00190	ko00000,ko00001,ko01000	NADH dehydrogenase
HOLOBFIM_02250	3.92e-104	-	-	-	S	-	-	-	NusG domain II
HOLOBFIM_02251	1.03e-127	hepA	2.5.1.30	-	S	ko:K00805	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Heptaprenyl diphosphate synthase component I
HOLOBFIM_02252	1.05e-228	hepT	2.5.1.30, 2.5.1.83	-	H	ko:K00805,ko:K21275	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Belongs to the FPP GGPP synthase family
HOLOBFIM_02254	1.33e-157	-	1.5.1.40	-	S	ko:K06988	-	ko00000,ko01000	Rossmann-like domain
HOLOBFIM_02255	1.22e-247	XK27_00915	-	-	C	-	-	-	Luciferase-like monooxygenase
HOLOBFIM_02256	1.65e-153	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_02257	1.3e-220	-	-	-	-	-	-	-	-
HOLOBFIM_02258	2.23e-186	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HOLOBFIM_02260	5.04e-127	yacP	-	-	S	ko:K06962	-	ko00000	YacP-like NYN domain
HOLOBFIM_02261	2.58e-180	trmH	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOLOBFIM_02262	4.83e-98	mrnC	-	-	J	ko:K11145	-	ko00000,ko01000,ko03009	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HOLOBFIM_02263	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HOLOBFIM_02264	0.0	loxD	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
HOLOBFIM_02265	1.53e-138	-	-	-	-	-	-	-	-
HOLOBFIM_02267	0.0	gltX	6.1.1.24	-	J	ko:K09698	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOLOBFIM_02268	8.13e-238	XK27_10475	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
HOLOBFIM_02269	2.59e-153	rpiA1	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
HOLOBFIM_02270	1.73e-182	-	-	-	K	-	-	-	SIS domain
HOLOBFIM_02271	2.26e-146	yhfC	-	-	S	-	-	-	Putative membrane peptidase family (DUF2324)
HOLOBFIM_02272	6.8e-227	-	-	-	S	-	-	-	Membrane
HOLOBFIM_02273	5.31e-82	-	-	-	K	-	-	-	helix_turn_helix gluconate operon transcriptional repressor
HOLOBFIM_02274	8.57e-289	inlJ	-	-	M	-	-	-	MucBP domain
HOLOBFIM_02275	6.47e-169	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_02276	4.17e-204	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_02277	7.21e-156	-	-	-	K	-	-	-	sequence-specific DNA binding
HOLOBFIM_02278	5.49e-261	yacL	-	-	S	-	-	-	domain protein
HOLOBFIM_02279	0.0	radA	-	-	O	ko:K04485	-	ko00000,ko03400	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HOLOBFIM_02280	3.99e-129	dut	3.6.1.23	-	F	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	dUTPase
HOLOBFIM_02281	1e-66	yjdJ	-	-	S	ko:K06975	-	ko00000	GCN5-related N-acetyl-transferase
HOLOBFIM_02282	5.93e-93	-	-	-	S	-	-	-	Protein of unknown function (DUF805)
HOLOBFIM_02283	0.0	pepE	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	aminopeptidase
HOLOBFIM_02284	0.0	pepC	3.4.22.40	-	E	ko:K01372	-	ko00000,ko01000,ko01002	Peptidase C1-like family
HOLOBFIM_02285	6.05e-251	-	-	-	-	ko:K01992	-	ko00000,ko00002,ko02000	-
HOLOBFIM_02286	2.13e-276	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_02287	1.17e-213	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_02288	0.0	kup	-	-	P	ko:K03549	-	ko00000,ko02000	Transport of potassium into the cell
HOLOBFIM_02289	0.0	ppdK	2.7.9.1	-	G	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Belongs to the PEP-utilizing enzyme family
HOLOBFIM_02290	8.84e-120	ccpN	-	-	K	-	-	-	Domain in cystathionine beta-synthase and other proteins.
HOLOBFIM_02291	1.19e-158	gpmA1	5.4.2.11	-	G	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HOLOBFIM_02292	4.71e-263	-	-	-	S	-	-	-	Bacterial low temperature requirement A protein (LtrA)
HOLOBFIM_02293	5.25e-61	-	-	-	-	-	-	-	-
HOLOBFIM_02294	2.84e-263	lctO	1.13.12.4	-	C	ko:K00467,ko:K10530	ko00620,map00620	ko00000,ko00001,ko01000	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
HOLOBFIM_02295	1.59e-28	yhjA	-	-	K	-	-	-	CsbD-like
HOLOBFIM_02297	1.5e-44	-	-	-	-	-	-	-	-
HOLOBFIM_02298	5.02e-52	-	-	-	-	-	-	-	-
HOLOBFIM_02299	8.53e-287	-	-	-	EGP	-	-	-	Transmembrane secretion effector
HOLOBFIM_02300	5.68e-280	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOLOBFIM_02301	1.05e-188	proB	2.7.2.11	-	F	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOLOBFIM_02303	2.57e-55	-	-	-	-	-	-	-	-
HOLOBFIM_02304	2.79e-295	-	-	-	S	-	-	-	Membrane
HOLOBFIM_02305	4.46e-189	-	3.4.22.70	-	M	ko:K07284	-	ko00000,ko01000,ko01002,ko01011	Sortase family
HOLOBFIM_02306	0.0	-	-	-	M	-	-	-	Cna protein B-type domain
HOLOBFIM_02307	2.47e-308	-	-	-	-	-	-	-	-
HOLOBFIM_02308	0.0	-	-	-	M	-	-	-	domain protein
HOLOBFIM_02309	1.05e-131	-	-	-	-	-	-	-	-
HOLOBFIM_02310	9.31e-294	-	-	-	N	ko:K09384	-	ko00000	Uncharacterized conserved protein (DUF2075)
HOLOBFIM_02311	5.7e-262	-	-	-	S	-	-	-	Protein of unknown function (DUF2974)
HOLOBFIM_02312	5.06e-144	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_02313	5.88e-72	padR	-	-	K	ko:K10947	-	ko00000,ko03000	Transcriptional regulator PadR-like family
HOLOBFIM_02314	6.77e-81	-	-	-	-	-	-	-	-
HOLOBFIM_02315	1.73e-175	-	-	-	-	-	-	-	-
HOLOBFIM_02316	6.69e-61	-	-	-	S	-	-	-	Enterocin A Immunity
HOLOBFIM_02317	7.18e-57	-	-	-	S	-	-	-	Enterocin A Immunity
HOLOBFIM_02318	2.45e-59	spiA	-	-	K	-	-	-	TRANSCRIPTIONal
HOLOBFIM_02319	0.0	-	-	-	S	-	-	-	Putative threonine/serine exporter
HOLOBFIM_02321	6.92e-81	-	-	-	-	-	-	-	-
HOLOBFIM_02322	2.29e-309	mesE	-	-	M	ko:K12293,ko:K20345	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko02000	Transport protein ComB
HOLOBFIM_02323	0.0	comA	-	-	V	ko:K06147,ko:K06148,ko:K12292,ko:K20344	ko02010,ko02020,ko02024,map02010,map02020,map02024	ko00000,ko00001,ko01000,ko02000	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
HOLOBFIM_02325	7.34e-174	-	2.7.13.3	-	T	ko:K02476,ko:K07706	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	protein histidine kinase activity
HOLOBFIM_02326	7.99e-184	plnD	-	-	K	ko:K07707	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HOLOBFIM_02328	1.49e-14	-	-	-	-	-	-	-	-
HOLOBFIM_02332	8.51e-183	-	-	-	S	-	-	-	CAAX protease self-immunity
HOLOBFIM_02334	5.62e-75	-	-	-	-	-	-	-	-
HOLOBFIM_02336	3.38e-72	-	-	-	S	-	-	-	Enterocin A Immunity
HOLOBFIM_02337	8.81e-135	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
HOLOBFIM_02341	9.77e-230	ydhF	-	-	S	-	-	-	Aldo keto reductase
HOLOBFIM_02342	3.51e-166	-	-	-	S	-	-	-	Belongs to the short-chain dehydrogenases reductases (SDR) family
HOLOBFIM_02343	3.36e-270	yqiG	-	-	C	-	-	-	Oxidoreductase
HOLOBFIM_02344	0.0	fumC	4.2.1.2	-	C	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	ko00000,ko00001,ko00002,ko01000	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
HOLOBFIM_02345	1.05e-171	-	-	-	-	-	-	-	-
HOLOBFIM_02346	6.42e-28	-	-	-	-	-	-	-	-
HOLOBFIM_02347	0.0	mntH	-	-	P	ko:K03322	-	ko00000,ko02000	H( )-stimulated, divalent metal cation uptake system
HOLOBFIM_02348	0.0	atp2C1	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	P-type ATPase
HOLOBFIM_02349	9.77e-74	-	-	-	-	-	-	-	-
HOLOBFIM_02350	4.42e-306	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HOLOBFIM_02351	0.0	sufI	-	-	Q	-	-	-	Multicopper oxidase
HOLOBFIM_02352	1.53e-35	-	-	-	-	-	-	-	-
HOLOBFIM_02353	2.22e-144	-	-	-	P	-	-	-	Cation efflux family
HOLOBFIM_02354	1.23e-69	czrA	-	-	K	ko:K22043	-	ko00000,ko03000	Transcriptional regulator, ArsR family
HOLOBFIM_02355	6.58e-226	mntA	-	-	P	ko:K19975,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HOLOBFIM_02356	5.89e-185	mtsB	-	-	U	ko:K19972,ko:K19976	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC 3 transport family
HOLOBFIM_02357	3.38e-170	-	3.6.3.35	-	P	ko:K19973	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
HOLOBFIM_02358	0.0	aldA	1.2.1.21, 1.2.1.22	-	C	ko:K07248	ko00620,ko00630,ko01120,map00620,map00630,map01120	ko00000,ko00001,ko01000	Belongs to the aldehyde dehydrogenase family
HOLOBFIM_02359	2.79e-54	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOLOBFIM_02360	2.26e-213	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HOLOBFIM_02361	1.15e-151	-	-	-	GM	-	-	-	NmrA-like family
HOLOBFIM_02362	6.65e-145	yjhB	3.6.1.13	-	F	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	NUDIX domain
HOLOBFIM_02363	2.87e-101	-	-	-	-	-	-	-	-
HOLOBFIM_02364	0.0	-	-	-	M	-	-	-	domain protein
HOLOBFIM_02365	1.03e-211	psaA	-	-	P	ko:K02077,ko:K11707	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Belongs to the bacterial solute-binding protein 9 family
HOLOBFIM_02366	2.1e-27	-	-	-	-	-	-	-	-
HOLOBFIM_02367	1.09e-95	-	-	-	-	-	-	-	-
HOLOBFIM_02369	3.56e-68	crcB	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLOBFIM_02370	7.54e-90	crcB1	-	-	U	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOLOBFIM_02373	1.06e-280	eno	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
HOLOBFIM_02374	2.87e-285	-	-	-	P	-	-	-	Cation transporter/ATPase, N-terminus
HOLOBFIM_02375	1.99e-212	phnD	-	-	P	ko:K02044	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Phosphonate ABC transporter
HOLOBFIM_02376	1.49e-178	phnC	3.6.3.28	-	P	ko:K02041	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HOLOBFIM_02377	1e-173	phnB	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_02378	2.69e-186	ptxC	-	-	P	ko:K02042	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_02379	1.22e-222	ssuA	-	-	P	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	NMT1-like family
HOLOBFIM_02380	0.0	-	6.2.1.48	-	IQ	ko:K02182	-	ko00000,ko01000	AMP-binding enzyme C-terminal domain
HOLOBFIM_02381	1.06e-296	-	-	-	I	-	-	-	Acyltransferase family
HOLOBFIM_02382	1.17e-154	ssuB	-	-	P	ko:K15555	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_02383	3.41e-191	ssuC	-	-	U	ko:K15554	ko00920,ko02010,map00920,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
HOLOBFIM_02384	3.1e-172	XK27_06950	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_02385	3.49e-172	XK27_06945	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
HOLOBFIM_02386	2.47e-169	-	-	-	S	ko:K01990	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_02387	1.6e-121	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
HOLOBFIM_02388	1.28e-12	-	-	-	S	-	-	-	Protein of unknown function (DUF2785)
HOLOBFIM_02389	8.78e-144	-	-	-	-	-	-	-	-
HOLOBFIM_02390	2.42e-70	-	-	-	-	-	-	-	-
HOLOBFIM_02391	8.98e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uS9 family
HOLOBFIM_02392	2.98e-104	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HOLOBFIM_02393	2.95e-140	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
HOLOBFIM_02394	1.06e-237	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	FtsX-like permease family
HOLOBFIM_02395	7.4e-164	lolD	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
HOLOBFIM_02396	1.5e-44	-	-	-	-	-	-	-	-
HOLOBFIM_02397	4.41e-169	tipA	-	-	K	-	-	-	TipAS antibiotic-recognition domain
HOLOBFIM_02398	1.39e-178	truA	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
HOLOBFIM_02399	9.32e-181	ecfT	-	-	U	ko:K16785	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HOLOBFIM_02400	1.92e-202	ecfA2	-	-	P	ko:K16787	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HOLOBFIM_02401	1.15e-197	ecfA1	-	-	P	ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HOLOBFIM_02402	9.02e-154	-	-	-	-	-	-	-	-
HOLOBFIM_02403	5.46e-81	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
HOLOBFIM_02404	1.26e-218	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLOBFIM_02405	3.82e-82	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOLOBFIM_02406	5.37e-76	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOLOBFIM_02407	6.38e-20	rpmJ	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL36 family
HOLOBFIM_02408	4.15e-46	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOLOBFIM_02409	1.29e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
HOLOBFIM_02410	2.01e-303	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
HOLOBFIM_02411	4.07e-92	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to the 23S rRNA
HOLOBFIM_02412	2.6e-33	rpmD	-	-	J	ko:K02907	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L30
HOLOBFIM_02413	5.74e-109	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HOLOBFIM_02414	1.62e-76	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HOLOBFIM_02415	2.61e-123	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOLOBFIM_02416	1.32e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HOLOBFIM_02417	8.67e-124	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOLOBFIM_02418	1.18e-66	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HOLOBFIM_02419	1.73e-77	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HOLOBFIM_02420	5.93e-55	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOLOBFIM_02421	3.55e-33	rpmC	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the universal ribosomal protein uL29 family
HOLOBFIM_02422	1.38e-98	rplP	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HOLOBFIM_02423	6.88e-152	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOLOBFIM_02424	4.5e-73	rplV	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOLOBFIM_02425	5.26e-63	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOLOBFIM_02426	7.23e-201	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HOLOBFIM_02427	1.02e-61	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
HOLOBFIM_02428	1.98e-140	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the polypeptide exit tunnel
HOLOBFIM_02429	4.01e-146	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOLOBFIM_02430	4.46e-66	rpsJ	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Involved in the binding of tRNA to the ribosomes
HOLOBFIM_02431	3.63e-90	psiE	-	-	S	ko:K13256	-	ko00000	Phosphate-starvation-inducible E
HOLOBFIM_02432	2.38e-138	ahpC	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
HOLOBFIM_02433	5.87e-256	-	-	-	K	-	-	-	WYL domain
HOLOBFIM_02434	0.0	fusA	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOLOBFIM_02435	2.06e-108	rpsG	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
HOLOBFIM_02436	1.11e-92	rpsL	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HOLOBFIM_02437	0.0	-	-	-	M	-	-	-	domain protein
HOLOBFIM_02438	8.99e-48	-	3.4.23.43	-	-	ko:K02236	-	ko00000,ko00002,ko01000,ko02044	-
HOLOBFIM_02439	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLOBFIM_02440	0.0	rpoB	2.7.7.6	-	K	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOLOBFIM_02441	0.0	clpC	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
HOLOBFIM_02442	4.32e-105	ctsR	-	-	K	ko:K03708	-	ko00000,ko03000	Belongs to the CtsR family
HOLOBFIM_02452	5.19e-90	-	-	-	S	-	-	-	COG NOG38524 non supervised orthologous group
HOLOBFIM_02455	1.45e-46	-	-	-	-	-	-	-	-
HOLOBFIM_02456	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-II aminoacyl-tRNA synthetase family
HOLOBFIM_02457	5.32e-242	dus	-	-	J	ko:K05540	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOLOBFIM_02458	5.11e-209	hslO	-	-	O	ko:K04083	-	ko00000,ko03110	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HOLOBFIM_02459	4.18e-206	-	-	-	S	-	-	-	WxL domain surface cell wall-binding
HOLOBFIM_02460	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOLOBFIM_02461	1.14e-124	hpt	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the purine pyrimidine phosphoribosyltransferase family
HOLOBFIM_02462	8.96e-309	tilS	2.4.2.8, 6.3.4.19	-	J	ko:K04075,ko:K15780	ko00230,ko01100,ko01110,map00230,map01100,map01110	ko00000,ko00001,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
HOLOBFIM_02463	1.17e-105	yabR	-	-	J	ko:K07571	-	ko00000	RNA binding
HOLOBFIM_02465	7.17e-87	divIC	-	-	D	ko:K05589,ko:K13052	-	ko00000,ko03036	cell cycle
HOLOBFIM_02466	1.99e-53	yabO	-	-	J	-	-	-	S4 domain protein
HOLOBFIM_02467	0.0	yabM	-	-	S	ko:K03328	-	ko00000	Polysaccharide biosynthesis protein
HOLOBFIM_02468	0.0	mfd	-	-	L	ko:K03723	ko03420,map03420	ko00000,ko00001,ko01000,ko03400	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HOLOBFIM_02469	4.28e-131	pth	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
HOLOBFIM_02470	5.04e-232	ldh	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily. LDH family
HOLOBFIM_02471	0.0	-	-	-	S	-	-	-	Putative peptidoglycan binding domain
HOLOBFIM_02472	1.34e-154	-	-	-	S	-	-	-	(CBS) domain
HOLOBFIM_02473	1.19e-168	yciB	-	-	M	-	-	-	ErfK YbiS YcfS YnhG
HOLOBFIM_02474	0.0	gltD	1.4.1.13, 1.4.1.14	-	E	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
HOLOBFIM_02475	0.0	gltA	1.4.1.13, 1.4.1.14, 1.4.7.1	-	E	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	GXGXG motif
HOLOBFIM_02476	3.28e-111	queT	-	-	S	-	-	-	QueT transporter
HOLOBFIM_02477	5.68e-83	ndoA	-	-	L	ko:K07171	-	ko00000,ko01000,ko02048	Toxic component of a toxin-antitoxin (TA) module
HOLOBFIM_02478	4.66e-44	-	-	-	-	-	-	-	-
HOLOBFIM_02479	6.59e-277	alr	5.1.1.1	-	E	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOLOBFIM_02480	2.63e-82	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
HOLOBFIM_02481	0.0	cshA	3.6.4.13	-	F	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity
HOLOBFIM_02482	0.0	murF	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
HOLOBFIM_02483	1.7e-187	-	-	-	-	-	-	-	-
HOLOBFIM_02484	9.73e-08	-	-	-	-	-	-	-	-
HOLOBFIM_02485	4.35e-159	-	-	-	S	-	-	-	Tetratricopeptide repeat
HOLOBFIM_02486	2.61e-163	-	-	-	-	-	-	-	-
HOLOBFIM_02487	2.29e-87	-	-	-	-	-	-	-	-
HOLOBFIM_02488	2.28e-57	rpmE2	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
HOLOBFIM_02489	9.48e-300	murA	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOLOBFIM_02490	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
HOLOBFIM_02491	3.42e-202	ybbB	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_02492	1.15e-111	rpoE	-	-	K	ko:K03048	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
HOLOBFIM_02493	3.48e-103	ywiB	-	-	S	-	-	-	Domain of unknown function (DUF1934)
HOLOBFIM_02494	3.3e-199	lipL	2.3.1.200, 2.3.1.204	-	H	ko:K16869,ko:K18821	-	ko00000,ko01000	biotin lipoate A B protein ligase
HOLOBFIM_02495	0.0	ywfO	-	-	S	ko:K06885	-	ko00000	HD domain protein
HOLOBFIM_02496	1.41e-103	mutT	3.6.1.55	-	L	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
HOLOBFIM_02497	2.14e-237	-	-	-	S	-	-	-	DUF218 domain
HOLOBFIM_02498	1.31e-77	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HOLOBFIM_02499	1.68e-104	-	-	-	E	-	-	-	glutamate:sodium symporter activity
HOLOBFIM_02500	1.54e-73	nudA	-	-	S	-	-	-	ASCH
HOLOBFIM_02501	5.49e-301	-	-	-	L	ko:K07485	-	ko00000	Transposase
HOLOBFIM_02502	2.2e-225	prs	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOLOBFIM_02503	3.29e-299	glmU	2.3.1.157, 2.7.7.23	-	M	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOLOBFIM_02504	1.21e-284	ysaA	-	-	V	-	-	-	RDD family
HOLOBFIM_02505	1.01e-193	purR	-	-	F	ko:K09685	-	ko00000,ko03000	pur operon repressor
HOLOBFIM_02506	1.29e-154	ybbL	-	-	S	ko:K02068	-	ko00000,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_02507	5.89e-158	ybbM	-	-	S	ko:K02069	-	ko00000,ko00002,ko02000	Uncharacterised protein family (UPF0014)
HOLOBFIM_02508	1.99e-205	czcD	-	-	P	ko:K16264	-	ko00000,ko02000	cation diffusion facilitator family transporter
HOLOBFIM_02509	6.63e-232	ispE	2.7.1.148	-	F	ko:K00919,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko02000	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HOLOBFIM_02510	4.13e-51	veg	-	-	S	-	-	-	Biofilm formation stimulator VEG
HOLOBFIM_02511	1.75e-203	ksgA	2.1.1.182	-	J	ko:K02528	-	ko00000,ko01000,ko03009	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
HOLOBFIM_02512	6.78e-130	rnmV	3.1.26.8	-	J	ko:K05985	-	ko00000,ko01000	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HOLOBFIM_02513	1.06e-188	tatD	-	-	L	ko:K03424	-	ko00000,ko01000	hydrolase, TatD family
HOLOBFIM_02514	7.36e-104	manR	2.7.1.194, 2.7.1.200, 2.7.1.202, 2.7.1.204	-	G	ko:K02538,ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K03491,ko:K11201,ko:K20112	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOLOBFIM_02515	1.35e-239	lacD	4.1.2.40	-	G	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	ko00000,ko00001,ko01000	Belongs to the aldolase LacD family
HOLOBFIM_02516	3e-221	yqhA	-	-	G	-	-	-	Aldose 1-epimerase
HOLOBFIM_02517	6.82e-159	-	-	-	T	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	LytTr DNA-binding domain
HOLOBFIM_02518	8.65e-201	-	-	-	T	-	-	-	GHKL domain
HOLOBFIM_02519	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HOLOBFIM_02520	0.0	-	-	-	V	ko:K06147	-	ko00000,ko02000	ABC transporter
HOLOBFIM_02521	0.0	metG	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOLOBFIM_02522	4.11e-223	pepI	3.4.11.5	-	E	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	Releases the N-terminal proline from various substrates
HOLOBFIM_02523	1.46e-196	yunF	-	-	F	-	-	-	Protein of unknown function DUF72
HOLOBFIM_02524	1.09e-118	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
HOLOBFIM_02525	4.42e-218	-	1.1.1.27	-	C	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	ko00000,ko00001,ko01000,ko04147	Belongs to the LDH MDH superfamily
HOLOBFIM_02526	9.14e-139	yiiE	-	-	S	-	-	-	Protein of unknown function (DUF1211)
HOLOBFIM_02527	5.67e-165	cobB	-	-	K	ko:K12410	-	ko00000,ko01000	Sir2 family
HOLOBFIM_02528	6.41e-24	-	-	-	-	-	-	-	-
HOLOBFIM_02529	5.59e-220	-	-	-	-	-	-	-	-
HOLOBFIM_02531	3.08e-123	yxkA	-	-	S	ko:K06910	-	ko00000	Phosphatidylethanolamine-binding protein
HOLOBFIM_02532	4.7e-50	-	-	-	-	-	-	-	-
HOLOBFIM_02533	2.01e-204	ypuA	-	-	S	-	-	-	Protein of unknown function (DUF1002)
HOLOBFIM_02534	2.57e-223	ppx	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HOLOBFIM_02535	0.0	ppk	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HOLOBFIM_02536	0.0	ppx3	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	exopolyphosphatase
HOLOBFIM_02537	1.43e-223	ydhF	-	-	S	-	-	-	Aldo keto reductase
HOLOBFIM_02538	2.42e-197	-	-	-	Q	-	-	-	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
HOLOBFIM_02539	2.76e-120	ywnH	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
HOLOBFIM_02540	5.58e-306	dinF	-	-	V	-	-	-	MatE
HOLOBFIM_02541	7.19e-157	-	-	-	S	ko:K06872	-	ko00000	TPM domain
HOLOBFIM_02542	1.4e-133	lemA	-	-	S	ko:K03744	-	ko00000	LemA family
HOLOBFIM_02543	1.48e-246	trpS	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Belongs to the class-I aminoacyl-tRNA synthetase family
HOLOBFIM_02544	3.5e-253	-	-	-	V	-	-	-	efflux transmembrane transporter activity
HOLOBFIM_02545	0.0	gshR	1.8.1.7	-	C	ko:K00383	ko00480,ko04918,map00480,map04918	ko00000,ko00001,ko01000	Glutathione reductase
HOLOBFIM_02546	2.47e-224	proV	-	-	E	ko:K05847	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_02547	0.0	choS	-	-	EM	ko:K05845,ko:K05846	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
HOLOBFIM_02549	0.0	-	-	-	L	-	-	-	DNA helicase
HOLOBFIM_02550	6.89e-194	rlrG	-	-	K	ko:K21900	-	ko00000,ko03000	Transcriptional regulator
HOLOBFIM_02551	1.32e-221	ydiA	-	-	P	ko:K11041	ko05150,map05150	ko00000,ko00001,ko02042	Voltage-dependent anion channel
HOLOBFIM_02552	1.15e-147	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
HOLOBFIM_02554	8.52e-148	yagB	-	-	S	ko:K06950	-	ko00000	Metal dependent phosphohydrolases with conserved 'HD' motif.
HOLOBFIM_02555	6.41e-92	-	-	-	K	-	-	-	MarR family
HOLOBFIM_02556	0.0	uvrA3	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	excinuclease ABC
HOLOBFIM_02557	2.97e-244	yghZ	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo keto reductase family protein
HOLOBFIM_02558	3.79e-183	-	-	-	S	-	-	-	hydrolase
HOLOBFIM_02559	4.04e-79	-	-	-	-	-	-	-	-
HOLOBFIM_02560	1.99e-16	-	-	-	-	-	-	-	-
HOLOBFIM_02561	3.43e-138	-	-	-	S	-	-	-	Protein of unknown function (DUF1275)
HOLOBFIM_02562	7.43e-160	gpmB	-	-	G	ko:K15640	-	ko00000	Phosphoglycerate mutase family
HOLOBFIM_02563	4.88e-195	yitU	3.1.3.104	-	S	ko:K21064	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	hydrolase
HOLOBFIM_02564	3.01e-112	rnhA	3.1.26.4	-	L	ko:K03469	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOLOBFIM_02565	4.39e-213	-	-	-	K	-	-	-	LysR substrate binding domain
HOLOBFIM_02566	4.96e-290	-	-	-	EK	-	-	-	Aminotransferase, class I
HOLOBFIM_02567	1.59e-241	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOLOBFIM_02568	4.5e-99	ydfK	-	-	S	ko:K07150	-	ko00000	Protein of unknown function (DUF554)
HOLOBFIM_02569	5.24e-116	-	-	-	-	-	-	-	-
HOLOBFIM_02570	0.0	fruC	2.7.1.202	-	GT	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02571	4.43e-222	fruK-1	2.7.1.56	-	H	ko:K00882	ko00051,map00051	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
HOLOBFIM_02572	2.36e-167	rpl	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HOLOBFIM_02573	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOLOBFIM_02574	1.17e-33	-	-	-	T	-	-	-	PFAM SpoVT AbrB
HOLOBFIM_02576	2.73e-114	-	-	-	-	-	-	-	-
HOLOBFIM_02577	4.19e-286	dgoD	4.2.1.6, 4.2.1.8	-	M	ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Mandelate racemase muconate lactonizing enzyme
HOLOBFIM_02578	3.29e-313	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02579	2.9e-61	sgcB	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02580	1.02e-103	-	2.7.1.200	-	GT	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02581	5.89e-138	-	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HOLOBFIM_02582	0.0	-	-	-	G	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02583	5.54e-59	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIA subunit
HOLOBFIM_02584	5.16e-66	ptcB	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02585	0.0	bgl	3.2.1.21, 3.2.1.85, 3.2.1.86	GT1	G	ko:K01220,ko:K01223,ko:K05350	ko00010,ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00052,map00460,map00500,map00940,map01100,map01110	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 1 family
HOLOBFIM_02586	1.34e-198	ypbG	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
HOLOBFIM_02587	6.32e-311	-	-	-	S	ko:K09704	-	ko00000	Metal-independent alpha-mannosidase (GH125)
HOLOBFIM_02588	0.0	mngB	3.2.1.170	GH38	G	ko:K15524	-	ko00000,ko01000	Glycosyl hydrolases family 38 N-terminal domain
HOLOBFIM_02589	1.54e-307	-	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_02590	1.1e-172	-	-	-	K	ko:K03492	-	ko00000,ko03000	UbiC transcription regulator-associated domain protein
HOLOBFIM_02591	4.32e-175	-	4.1.2.17	-	G	ko:K01628	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Class II Aldolase and Adducin N-terminal domain
HOLOBFIM_02592	0.0	pts36C	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02593	5.31e-69	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02594	1.49e-107	pts36A	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02595	2.3e-186	rdrB	-	-	K	ko:K02444,ko:K22103	-	ko00000,ko03000	DeoR C terminal sensor domain
HOLOBFIM_02596	3.07e-204	-	-	-	J	-	-	-	Methyltransferase domain
HOLOBFIM_02597	0.0	-	3.2.1.10, 3.2.1.20	GH13,GH31	G	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain protein
HOLOBFIM_02599	1.15e-147	alkD	-	-	L	-	-	-	DNA alkylation repair enzyme
HOLOBFIM_02600	7.16e-163	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HOLOBFIM_02601	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOLOBFIM_02602	3.36e-219	ykoT	-	-	M	-	-	-	Glycosyl transferase family 2
HOLOBFIM_02603	2.13e-152	-	3.6.1.27	-	I	ko:K19302	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	phosphatase
HOLOBFIM_02604	4.65e-149	-	-	-	S	ko:K03975	-	ko00000	SNARE-like domain protein
HOLOBFIM_02605	9.8e-313	kinE	-	-	T	-	-	-	Histidine kinase
HOLOBFIM_02606	3.97e-162	llrE	-	-	K	-	-	-	Transcriptional regulatory protein, C terminal
HOLOBFIM_02607	0.0	-	3.2.1.122	GH4	G	ko:K01232	ko00500,map00500	ko00000,ko00001,ko01000	Family 4 glycosyl hydrolase C-terminal domain
HOLOBFIM_02608	0.0	-	2.7.1.199, 2.7.1.208	-	G	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphotransferase system, EIIB
HOLOBFIM_02609	0.0	hylB	4.2.2.1	PL8	N	ko:K01727	-	ko00000,ko01000	Polysaccharide lyase family 8, N terminal alpha-helical domain
HOLOBFIM_02610	0.0	-	-	-	-	-	-	-	-
HOLOBFIM_02612	1.35e-143	-	-	-	-	-	-	-	-
HOLOBFIM_02613	6.42e-112	-	-	-	-	-	-	-	-
HOLOBFIM_02614	1e-174	-	-	-	K	-	-	-	M protein trans-acting positive regulator
HOLOBFIM_02615	2.19e-152	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HOLOBFIM_02616	2.57e-109	ptbA	2.7.1.208	-	G	ko:K02755,ko:K02777,ko:K20107,ko:K20108	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
HOLOBFIM_02619	1.96e-86	-	-	-	S	-	-	-	Uncharacterised protein family UPF0047
HOLOBFIM_02620	4.52e-97	-	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Triose-phosphate isomerase
HOLOBFIM_02621	4.32e-123	gatY	4.1.2.13, 4.1.2.40	-	G	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_02622	1.57e-39	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphotransferase system, galactitol-specific IIB component
HOLOBFIM_02623	7.38e-204	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02624	3.29e-34	-	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)
HOLOBFIM_02626	1.39e-98	-	-	-	K	ko:K02538	-	ko00000,ko03000	PRD domain
HOLOBFIM_02627	5.9e-259	-	-	-	S	-	-	-	DUF218 domain
HOLOBFIM_02628	1.04e-141	-	4.1.2.17	-	G	ko:K01628	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Class II Aldolase and Adducin N-terminal domain
HOLOBFIM_02629	2.66e-214	-	1.1.1.14	-	E	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Alcohol dehydrogenase GroES-like domain
HOLOBFIM_02630	3.67e-244	-	-	-	G	ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02631	1.37e-43	-	2.7.1.200	-	G	ko:K02774	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	to PTS system, Galactitol-specific IIB component
HOLOBFIM_02632	2.29e-12	-	-	-	-	-	-	-	-
HOLOBFIM_02633	3.51e-55	-	2.7.1.200	-	G	ko:K02773	ko00052,ko01100,ko02060,map00052,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02634	2.1e-217	-	-	-	GKT	-	-	-	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02635	1.96e-155	pdxA	1.1.1.408, 1.1.1.409	-	H	ko:K22024	-	ko00000,ko01000	Belongs to the PdxA family
HOLOBFIM_02636	1.85e-109	-	2.7.1.219, 2.7.1.220	-	S	ko:K22129	-	ko00000,ko01000	Putative nucleotide-binding of sugar-metabolising enzyme
HOLOBFIM_02637	3.86e-132	kdgT	-	-	P	ko:K02526	-	ko00000,ko02000	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
HOLOBFIM_02638	1.13e-70	-	-	-	T	ko:K02667	ko02020,map02020	ko00000,ko00001,ko00002,ko02022,ko02035	phosphorelay signal transduction system
HOLOBFIM_02639	1.3e-86	kdsD	5.3.1.13	-	M	ko:K06041	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
HOLOBFIM_02640	8.2e-63	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02641	8.29e-44	-	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02642	1.77e-256	-	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02643	2.94e-122	-	4.3.3.7	-	E	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
HOLOBFIM_02644	5.38e-105	eda	4.1.2.14, 4.1.3.42	-	G	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	KDPG and KHG aldolase
HOLOBFIM_02645	1.33e-255	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02646	5.63e-177	-	4.1.2.14	-	S	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	ko00000,ko00001,ko00002,ko01000	KDGP aldolase
HOLOBFIM_02647	1.76e-259	selA	2.9.1.1	-	H	ko:K01042	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko01000	L-seryl-tRNA selenium transferase
HOLOBFIM_02648	2.47e-274	dho	3.5.2.3	-	S	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase family
HOLOBFIM_02649	3.79e-155	-	-	-	S	-	-	-	Domain of unknown function (DUF4310)
HOLOBFIM_02650	1.95e-175	-	-	-	S	-	-	-	Domain of unknown function (DUF4311)
HOLOBFIM_02651	1.1e-76	-	-	-	S	-	-	-	Domain of unknown function (DUF4312)
HOLOBFIM_02652	5.01e-80	-	-	-	S	-	-	-	Glycine-rich SFCGS
HOLOBFIM_02653	1.74e-72	-	-	-	S	-	-	-	PRD domain
HOLOBFIM_02654	0.0	-	-	-	K	-	-	-	Mga helix-turn-helix domain
HOLOBFIM_02655	8.74e-161	-	-	-	H	-	-	-	Pfam:Transaldolase
HOLOBFIM_02656	2.24e-84	-	2.7.1.198	-	G	ko:K02781	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system glucitol/sorbitol-specific IIA component
HOLOBFIM_02657	1.95e-250	srlE	2.7.1.198	-	G	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Sorbitol phosphotransferase enzyme II N-terminus
HOLOBFIM_02658	5.81e-131	srlA	-	-	G	ko:K02783	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko02000	PTS system enzyme II sorbitol-specific factor
HOLOBFIM_02659	2.63e-115	srlM1	-	-	K	-	-	-	Glucitol operon activator protein (GutM)
HOLOBFIM_02660	0.0	srlM	-	-	GKT	ko:K03491	-	ko00000,ko03000	Mga helix-turn-helix domain
HOLOBFIM_02661	4.13e-185	srlD2	1.1.1.140	-	IQ	ko:K00068	ko00051,map00051	ko00000,ko00001,ko01000	NAD dependent epimerase/dehydratase family
HOLOBFIM_02662	1.57e-177	araD	5.1.3.4	-	G	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
HOLOBFIM_02663	1.45e-193	-	-	-	S	-	-	-	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_02664	2.97e-210	sga	5.1.3.22	-	G	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Xylose isomerase-like TIM barrel
HOLOBFIM_02665	8.64e-178	-	-	-	K	-	-	-	DeoR C terminal sensor domain
HOLOBFIM_02666	5.26e-148	ulaD	4.1.1.85, 4.1.2.43	-	G	ko:K03078,ko:K08093	ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
HOLOBFIM_02667	3.36e-61	sgaB	2.7.1.194	-	G	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02668	0.0	sgaT	-	-	S	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sugar-specific permease component
HOLOBFIM_02669	4.89e-105	-	2.7.1.194	-	G	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
HOLOBFIM_02670	4.59e-275	ulaG	-	-	S	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Beta-lactamase superfamily domain
HOLOBFIM_02671	9.37e-159	rpiA	5.3.1.6	-	G	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HOLOBFIM_02672	2.58e-253	-	1.1.1.14	-	C	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	ko00000,ko00001,ko00002,ko01000	Zinc-binding dehydrogenase
HOLOBFIM_02673	6.04e-118	-	-	-	G	-	-	-	DeoC/LacD family aldolase
HOLOBFIM_02674	1.15e-154	rpe	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Belongs to the ribulose-phosphate 3-epimerase family
HOLOBFIM_02675	1.29e-201	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_02676	1.95e-172	-	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_02677	2.79e-107	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_02678	5.03e-95	-	2.7.1.191	-	G	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system fructose IIA component
HOLOBFIM_02679	1.77e-262	-	1.1.1.405	-	E	ko:K05352	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko01000	Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate
HOLOBFIM_02680	4.79e-173	-	-	-	K	-	-	-	DeoR C terminal sensor domain
HOLOBFIM_02681	0.0	xfp	4.1.2.22, 4.1.2.9	-	G	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	ko00000,ko00001,ko01000	Phosphoketolase
HOLOBFIM_02682	9.42e-203	-	-	-	GK	-	-	-	ROK family
HOLOBFIM_02683	7.44e-231	asnA2	3.5.1.1	-	E	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	ko00000,ko00001,ko01000	Asparaginase
HOLOBFIM_02684	0.0	-	-	-	E	-	-	-	Peptidase family M20/M25/M40
HOLOBFIM_02685	3.03e-169	-	-	-	K	ko:K03710	-	ko00000,ko03000	UTRA
HOLOBFIM_02686	0.0	-	4.1.1.12	-	E	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	ko00000,ko00001,ko01000	Aminotransferase
HOLOBFIM_02687	5.58e-271	-	-	-	EGP	-	-	-	Transporter, major facilitator family protein
HOLOBFIM_02688	5.93e-265	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
HOLOBFIM_02689	5.35e-113	-	-	-	M	ko:K03828	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HOLOBFIM_02690	2.99e-78	-	-	-	K	-	-	-	AAA domain
HOLOBFIM_02691	7.7e-105	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_02692	1.17e-117	yveA	-	-	Q	-	-	-	Isochorismatase family
HOLOBFIM_02693	4.83e-63	-	-	-	S	-	-	-	Zeta toxin
HOLOBFIM_02694	9.7e-164	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
HOLOBFIM_02695	9.26e-133	-	-	-	IQ	-	-	-	KR domain
HOLOBFIM_02696	9.11e-85	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_02697	4.09e-46	-	-	-	G	-	-	-	PTS system fructose IIA component
HOLOBFIM_02698	3.26e-311	-	-	-	G	-	-	-	PTS system sorbose-specific iic component
HOLOBFIM_02699	9.04e-191	-	-	-	E	-	-	-	Alcohol dehydrogenase GroES-like domain
HOLOBFIM_02700	3.93e-104	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HOLOBFIM_02701	7.48e-47	-	-	-	-	-	-	-	-
HOLOBFIM_02702	1.12e-74	ps105	-	-	-	-	-	-	-
HOLOBFIM_02704	1.27e-123	-	-	-	K	-	-	-	Helix-turn-helix domain
HOLOBFIM_02705	3.79e-155	glpQ1	3.1.4.46	-	C	ko:K01126	ko00564,map00564	ko00000,ko00001,ko01000	glycerophosphoryl diester phosphodiesterase
HOLOBFIM_02706	1.36e-91	arsC	1.20.4.1	-	T	ko:K03741	-	ko00000,ko01000	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOLOBFIM_02707	0.0	ugpB	-	-	G	ko:K05813	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding protein
HOLOBFIM_02708	2.92e-192	ugpE	-	-	G	ko:K05815	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_02709	1.3e-210	-	-	-	P	ko:K05814	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC-type sugar transport systems, permease components
HOLOBFIM_02710	7.33e-271	ugpC	3.6.3.20	-	E	ko:K05816,ko:K10112	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Belongs to the ABC transporter superfamily
HOLOBFIM_02711	0.0	nadC2	6.3.4.21	-	F	ko:K00763	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HOLOBFIM_02712	1.89e-139	pncA	-	-	Q	-	-	-	Isochorismatase family
HOLOBFIM_02713	5.44e-174	-	-	-	F	-	-	-	NUDIX domain
HOLOBFIM_02714	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
HOLOBFIM_02715	1.45e-187	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
HOLOBFIM_02716	7.56e-244	ykfB	5.1.1.20	-	M	ko:K19802	-	ko00000,ko01000	Belongs to the mandelate racemase muconate lactonizing enzyme family
HOLOBFIM_02717	6.28e-249	-	-	-	V	-	-	-	Beta-lactamase
HOLOBFIM_02718	4.1e-197	murQ	4.2.1.126	-	G	ko:K07106	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HOLOBFIM_02719	3.72e-210	-	-	-	K	-	-	-	Helix-turn-helix domain, rpiR family
HOLOBFIM_02720	1.67e-105	-	2.7.1.191	-	G	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_02721	1.56e-192	-	-	-	G	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system mannose/fructose/sorbose family IID component
HOLOBFIM_02722	8.76e-177	XK27_08455	-	-	G	ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system sorbose-specific iic component
HOLOBFIM_02723	3.04e-259	-	-	-	S	-	-	-	endonuclease exonuclease phosphatase family protein
HOLOBFIM_02724	1.79e-217	nrnA	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain protein
HOLOBFIM_02725	1.95e-133	-	-	-	Q	-	-	-	Methyltransferase
HOLOBFIM_02726	2.16e-68	sugE	-	-	U	ko:K11741	-	ko00000,ko02000	Multidrug resistance protein
HOLOBFIM_02727	5.44e-174	-	-	-	S	-	-	-	-acetyltransferase
HOLOBFIM_02728	4.76e-121	yfbM	-	-	K	-	-	-	FR47-like protein
HOLOBFIM_02729	1.4e-121	-	-	-	E	-	-	-	HAD-hyrolase-like
HOLOBFIM_02730	7.69e-232	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	nadph quinone reductase
HOLOBFIM_02731	1.33e-178	ptp1	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Tyrosine phosphatase family
HOLOBFIM_02732	9.48e-120	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_02733	7.83e-108	yiaC	-	-	K	ko:K03826	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HOLOBFIM_02734	1.34e-98	-	-	-	K	ko:K03830	-	ko00000,ko01000	Acetyltransferase (GNAT) domain
HOLOBFIM_02735	5.84e-105	rlmH	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HOLOBFIM_02736	6.32e-253	ysdE	-	-	P	-	-	-	Citrate transporter
HOLOBFIM_02737	6.13e-91	-	-	-	-	-	-	-	-
HOLOBFIM_02738	0.0	dapE	3.5.1.18	-	E	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	ko00000,ko00001,ko00002,ko01000	Peptidase dimerisation domain
HOLOBFIM_02739	0.0	oppA	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	ABC transporter, substratebinding protein
HOLOBFIM_02740	4.2e-134	-	-	-	-	-	-	-	-
HOLOBFIM_02741	0.0	cadA	-	-	P	-	-	-	P-type ATPase
HOLOBFIM_02742	1.8e-99	hsp3	-	-	O	ko:K13993	ko04141,map04141	ko00000,ko00001,ko03110	Belongs to the small heat shock protein (HSP20) family
HOLOBFIM_02743	2.35e-92	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HOLOBFIM_02744	1.7e-284	htrA	3.4.21.107	-	O	ko:K04771	ko01503,ko02020,map01503,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	serine protease
HOLOBFIM_02745	4.32e-196	vicX	3.1.26.11	-	S	ko:K00784	ko03013,map03013	ko00000,ko00001,ko01000,ko03016	domain protein
HOLOBFIM_02746	1.05e-182	yycI	-	-	S	-	-	-	YycH protein
HOLOBFIM_02747	0.0	yycH	-	-	S	-	-	-	YycH protein
HOLOBFIM_02748	0.0	vicK	2.7.13.3	-	T	ko:K07652	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Histidine kinase
HOLOBFIM_02749	3.03e-168	yycF	-	-	K	ko:K07668	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	response regulator
HOLOBFIM_02750	4.31e-157	-	1.11.1.10	-	S	ko:K00433	-	ko00000,ko01000	Alpha/beta hydrolase family
HOLOBFIM_02751	0.0	arpJ	-	-	P	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	ABC transporter permease
HOLOBFIM_02752	1.63e-298	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Belongs to the argininosuccinate synthase family. Type 1 subfamily
HOLOBFIM_02753	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	argininosuccinate lyase
HOLOBFIM_02754	7.93e-272	ybhE	-	-	S	ko:K09963	-	ko00000	Bacterial protein of unknown function (DUF871)
HOLOBFIM_02755	9.09e-97	-	-	-	S	-	-	-	Domain of unknown function (DUF3284)
HOLOBFIM_02756	1.76e-298	chbC	-	-	G	ko:K02761	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko02000	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_02757	1.97e-168	gntR	-	-	K	ko:K03489	-	ko00000,ko03000	UTRA
HOLOBFIM_02758	5.86e-68	pts20B	2.7.1.196, 2.7.1.205	-	G	ko:K02760	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02759	4.84e-71	celC	2.7.1.196, 2.7.1.205	-	G	ko:K02759	ko00500,ko02060,map00500,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose Cellobiose specific IIA subunit
HOLOBFIM_02760	3.54e-138	yokL3	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
HOLOBFIM_02761	1.06e-109	-	-	-	F	-	-	-	NUDIX domain
HOLOBFIM_02762	3.71e-117	-	-	-	S	-	-	-	AAA domain
HOLOBFIM_02763	3.32e-148	ycaC	-	-	Q	-	-	-	Isochorismatase family
HOLOBFIM_02764	0.0	-	-	-	EGP	-	-	-	Major Facilitator Superfamily
HOLOBFIM_02765	4.42e-271	yycB	-	-	P	ko:K03449	-	ko00000,ko02000	Transporter, major facilitator family protein
HOLOBFIM_02766	1.17e-217	iolS	-	-	C	ko:K06607	-	ko00000,ko01000	Aldo keto reductase
HOLOBFIM_02767	1.08e-84	manO	-	-	S	-	-	-	Domain of unknown function (DUF956)
HOLOBFIM_02768	2.45e-216	manN	-	-	G	ko:K02796,ko:K02815	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	system, mannose fructose sorbose family IID component
HOLOBFIM_02769	1.57e-171	manM	-	-	G	ko:K02746,ko:K02795,ko:K02814	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	ko00000,ko00001,ko00002,ko02000	PTS system
HOLOBFIM_02770	1.44e-230	manL	2.7.1.191, 2.7.1.202	-	G	ko:K02769,ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system sorbose subfamily IIB component
HOLOBFIM_02771	9.77e-279	-	-	-	EGP	-	-	-	Major facilitator Superfamily
HOLOBFIM_02773	8.86e-244	-	-	-	K	ko:K20373	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
HOLOBFIM_02774	1.96e-191	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
HOLOBFIM_02775	6.17e-204	ywdE	-	-	K	ko:K20375	ko02024,map02024	ko00000,ko00001,ko03000	Helix-turn-helix XRE-family like proteins
HOLOBFIM_02777	0.0	XK27_05795	-	-	P	ko:K17073,ko:K17074	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter permease
HOLOBFIM_02778	3.81e-172	glnQ	-	-	E	ko:K17076	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_02779	4.51e-41	-	-	-	-	-	-	-	-
HOLOBFIM_02780	1.65e-302	-	-	-	G	ko:K02027	-	ko00000,ko00002,ko02000	Bacterial extracellular solute-binding protein
HOLOBFIM_02781	1.33e-166	-	-	-	S	-	-	-	Protein of unknown function (DUF975)
HOLOBFIM_02782	5.96e-53	-	-	-	S	-	-	-	Iron-sulphur cluster biosynthesis
HOLOBFIM_02783	8.12e-69	-	-	-	-	-	-	-	-
HOLOBFIM_02784	8.68e-106	ydbS	-	-	S	ko:K09167	-	ko00000	Bacterial PH domain
HOLOBFIM_02785	0.0	ydbT	-	-	S	ko:K08981	-	ko00000	Bacterial PH domain
HOLOBFIM_02786	7.76e-186	-	-	-	S	-	-	-	AAA ATPase domain
HOLOBFIM_02787	4.58e-214	-	-	-	G	-	-	-	Phosphotransferase enzyme family
HOLOBFIM_02788	1.09e-170	glnQ	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
HOLOBFIM_02789	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_02790	0.0	glnP	-	-	P	ko:K02029,ko:K02030,ko:K10036	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ABC transporter
HOLOBFIM_02791	9.37e-129	ydaF	-	-	J	ko:K03817	-	ko00000,ko01000,ko03009	Acetyltransferase (GNAT) domain
HOLOBFIM_02792	2.22e-137	-	-	-	S	ko:K06384	-	ko00000	Stage II sporulation protein M
HOLOBFIM_02793	1.82e-182	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
HOLOBFIM_02794	1.06e-235	-	-	-	S	-	-	-	Protein of unknown function DUF58
HOLOBFIM_02795	0.0	yebA	-	-	E	-	-	-	Transglutaminase/protease-like homologues
HOLOBFIM_02796	3e-273	-	-	-	M	-	-	-	Glycosyl transferases group 1
HOLOBFIM_02797	1.34e-126	thgA3	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
HOLOBFIM_02798	4.23e-16	-	3.1.3.102, 3.1.3.104, 3.1.3.23	-	G	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_02799	4.31e-155	-	3.1.3.102, 3.1.3.104, 3.1.3.23	-	G	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Sucrose-6F-phosphate phosphohydrolase
HOLOBFIM_02800	0.0	aspA	4.3.1.1	-	E	ko:K01744	ko00250,ko01100,map00250,map01100	ko00000,ko00001,ko01000	Fumarase C C-terminus
HOLOBFIM_02801	6.79e-146	-	-	-	S	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
HOLOBFIM_02802	5.19e-62	yjdF3	-	-	S	-	-	-	Protein of unknown function (DUF2992)
HOLOBFIM_02803	3.65e-272	mae	1.1.1.38	-	C	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	ko00000,ko00001,ko01000	Malic enzyme, NAD binding domain
HOLOBFIM_02804	5.39e-292	malP	-	-	C	ko:K11616	ko02020,map02020	ko00000,ko00001	2-hydroxycarboxylate transporter family
HOLOBFIM_02805	0.0	dpiB	2.7.13.3	-	T	ko:K02476,ko:K11614	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Single cache domain 3
HOLOBFIM_02806	3.66e-156	malR	-	-	KT	ko:K02475,ko:K11615	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	cheY-homologous receiver domain
HOLOBFIM_02807	5.21e-193	-	-	-	I	-	-	-	NAD binding domain of 6-phosphogluconate dehydrogenase
HOLOBFIM_02808	1.79e-122	M1-431	-	-	S	-	-	-	Protein of unknown function (DUF1706)
HOLOBFIM_02809	5.28e-85	-	-	-	-	-	-	-	-
HOLOBFIM_02810	7.49e-283	yagE	-	-	E	-	-	-	Amino acid permease
HOLOBFIM_02811	4.08e-218	-	-	-	O	-	-	-	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HOLOBFIM_02812	1.51e-281	sip	-	-	L	-	-	-	Belongs to the 'phage' integrase family
HOLOBFIM_02815	2.23e-76	-	-	-	-	-	-	-	-
HOLOBFIM_02816	7.73e-18	-	-	-	-	-	-	-	-
HOLOBFIM_02818	2.6e-33	-	-	-	-	-	-	-	-
HOLOBFIM_02819	7.49e-197	-	-	-	L	-	-	-	Bifunctional DNA primase/polymerase, N-terminal
HOLOBFIM_02820	0.0	-	-	-	S	-	-	-	Virulence-associated protein E
HOLOBFIM_02824	2.26e-27	-	-	-	L	-	-	-	HNH endonuclease
HOLOBFIM_02825	6.04e-92	terS	-	-	L	-	-	-	Phage terminase, small subunit
HOLOBFIM_02826	0.0	terL	-	-	S	-	-	-	overlaps another CDS with the same product name
HOLOBFIM_02827	2.56e-30	-	-	-	-	-	-	-	-
HOLOBFIM_02828	5.01e-275	-	-	-	S	-	-	-	Phage portal protein
HOLOBFIM_02829	0.0	-	-	-	S	ko:K06904	-	ko00000	Phage capsid family
HOLOBFIM_02830	7.93e-60	-	-	-	S	-	-	-	Phage gp6-like head-tail connector protein
HOLOBFIM_02833	1.89e-22	-	-	-	-	-	-	-	-
HOLOBFIM_02834	1.4e-35	ytgB	-	-	S	-	-	-	Transglycosylase associated protein
HOLOBFIM_02835	5.11e-52	mscL	-	-	M	ko:K03282	-	ko00000,ko02000	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
HOLOBFIM_02837	1.87e-217	prs2	2.7.6.1	-	F	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOLOBFIM_02838	2.32e-233	-	-	-	D	ko:K06889	-	ko00000	Alpha beta
HOLOBFIM_02839	5.29e-239	lipA	-	-	I	-	-	-	Carboxylesterase family
HOLOBFIM_02840	1.68e-275	mtlD	1.1.1.17	-	C	ko:K00009	ko00051,map00051	ko00000,ko00001,ko01000	mannitol-1-phosphate 5-dehydrogenase activity
HOLOBFIM_02841	9.2e-101	mtlF	2.7.1.197	-	G	ko:K02798	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
HOLOBFIM_02842	0.0	mtlR	-	-	K	ko:K03483	-	ko00000,ko03000	Mga helix-turn-helix domain
HOLOBFIM_02843	0.0	mtlA	2.7.1.197	-	G	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	PTS system, Lactose/Cellobiose specific IIB subunit
HOLOBFIM_02844	2.09e-169	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
HOLOBFIM_02845	3.86e-192	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
HOLOBFIM_02846	5.93e-59	-	-	-	-	-	-	-	-
HOLOBFIM_02847	6.72e-19	-	-	-	-	-	-	-	-
HOLOBFIM_02848	1.51e-238	hlyD3	-	-	M	ko:K02005	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOLOBFIM_02849	8.32e-160	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ABC transporter
HOLOBFIM_02850	4.88e-263	yknZ	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
HOLOBFIM_02851	0.0	-	-	-	M	-	-	-	Leucine rich repeats (6 copies)
HOLOBFIM_02852	2.58e-254	ypjH	-	-	C	ko:K08317	-	ko00000,ko01000	dehydrogenase
HOLOBFIM_02853	1.27e-174	amd	-	-	E	-	-	-	Peptidase family M20/M25/M40
HOLOBFIM_02854	1.38e-75	amd	-	-	E	-	-	-	Peptidase family M20/M25/M40
HOLOBFIM_02855	2.98e-104	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
HOLOBFIM_02856	3.8e-175	labL	-	-	S	-	-	-	Putative threonine/serine exporter
HOLOBFIM_02858	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
HOLOBFIM_02859	0.0	mnmE	-	-	S	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HOLOBFIM_02860	1.42e-170	jag	-	-	S	ko:K06346	-	ko00000	R3H domain protein
HOLOBFIM_02861	4.53e-179	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HOLOBFIM_02862	2.99e-77	rnpA	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
HOLOBFIM_02863	3.26e-23	rpmH	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Belongs to the bacterial ribosomal protein bL34 family
HOLOBFIM_02864	1.55e-34	-	-	-	-	-	-	-	-
HOLOBFIM_02865	3.28e-148	pinR1	-	-	L	-	-	-	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed
HOLOBFIM_02866	1.1e-60	-	-	-	L	-	-	-	BRCA1 C Terminus (BRCT) domain
HOLOBFIM_02867	6.96e-118	-	-	-	-	-	-	-	-
HOLOBFIM_02868	1.87e-88	-	-	-	S	ko:K07006	-	ko00000	Pyridoxamine 5'-phosphate oxidase
HOLOBFIM_02869	0.0	-	-	-	M	-	-	-	Cna protein B-type domain
HOLOBFIM_02870	3.93e-219	-	-	-	L	-	-	-	Transposase and inactivated derivatives, IS30 family
HOLOBFIM_02871	1.91e-76	traI	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	This gene contains a nucleotide ambiguity which may be the result of a sequencing error
HOLOBFIM_02872	0.0	traA	-	-	L	-	-	-	MobA MobL family protein
HOLOBFIM_02873	6.89e-37	-	-	-	-	-	-	-	-
HOLOBFIM_02874	8.5e-55	-	-	-	-	-	-	-	-
HOLOBFIM_02875	8.77e-77	-	-	-	L	-	-	-	Putative transposase of IS4/5 family (DUF4096)
HOLOBFIM_02876	1.07e-87	-	-	-	L	-	-	-	Transposase DDE domain
HOLOBFIM_02877	2.55e-145	epsG	-	-	M	-	-	-	Glycosyltransferase like family 2
HOLOBFIM_02878	0.0	glpK	2.7.1.30	-	F	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	ko00000,ko00001,ko01000,ko04147	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOLOBFIM_02879	0.0	glpD	1.1.3.21, 1.1.5.3	-	C	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	C-terminal domain of alpha-glycerophosphate oxidase
HOLOBFIM_02880	2.82e-172	glpF	-	-	U	ko:K02440	-	ko00000,ko02000	Belongs to the MIP aquaporin (TC 1.A.8) family
HOLOBFIM_02881	1.22e-143	ung2	-	-	L	-	-	-	Uracil-DNA glycosylase
HOLOBFIM_02882	2.36e-87	-	-	-	L	-	-	-	ATPase domain of DNA mismatch repair MUTS family
HOLOBFIM_02883	7.52e-88	-	-	-	L	-	-	-	Transposase DDE domain
HOLOBFIM_02884	8.77e-77	-	-	-	L	-	-	-	Putative transposase of IS4/5 family (DUF4096)
HOLOBFIM_02885	3.31e-113	-	-	-	L	-	-	-	ATPase domain of DNA mismatch repair MUTS family
HOLOBFIM_02886	8.37e-108	-	-	-	L	-	-	-	Transposase DDE domain
HOLOBFIM_02888	2.61e-88	-	-	-	K	-	-	-	Primase C terminal 1 (PriCT-1)
HOLOBFIM_02889	3.01e-114	-	-	-	D	-	-	-	AAA domain
HOLOBFIM_02890	2.47e-105	-	-	-	L	-	-	-	Initiator Replication protein
HOLOBFIM_02892	1.55e-19	-	-	-	-	-	-	-	-
HOLOBFIM_02894	4.04e-07	-	-	-	-	-	-	-	-
HOLOBFIM_02897	3.29e-98	-	-	-	V	-	-	-	HNH endonuclease