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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
DIFFNHDI_00002	2.01e-48	-	-	-	T	-	-	-	pathogenesis
DIFFNHDI_00003	0.0	-	2.3.1.40, 6.2.1.20	-	IQ	ko:K05939	ko00071,ko00564,map00071,map00564	ko00000,ko00001,ko01000	AMP-binding enzyme
DIFFNHDI_00004	0.0	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
DIFFNHDI_00005	6.39e-71	-	-	-	-	-	-	-	-
DIFFNHDI_00008	2.23e-205	-	-	-	S	ko:K03453	-	ko00000	Bile acid
DIFFNHDI_00009	6.3e-291	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DIFFNHDI_00010	2.18e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
DIFFNHDI_00011	3.89e-209	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DIFFNHDI_00012	3.73e-176	-	-	-	-	-	-	-	-
DIFFNHDI_00014	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RQC
DIFFNHDI_00018	2.29e-229	-	-	-	S	-	-	-	mannose-ethanolamine phosphotransferase activity
DIFFNHDI_00020	7.16e-115	-	-	-	S	ko:K03748	-	ko00000	DUF218 domain
DIFFNHDI_00022	3.15e-103	-	-	-	J	-	-	-	YjgF/chorismate_mutase-like, putative endoribonuclease
DIFFNHDI_00023	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00024	3.01e-113	-	1.16.3.2	-	P	ko:K02217	-	ko00000,ko01000	Ferritin-like domain
DIFFNHDI_00026	4.98e-92	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
DIFFNHDI_00027	1.25e-307	-	4.2.1.20	-	E	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DIFFNHDI_00028	9.8e-232	-	2.7.1.221	-	S	ko:K07102	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Phosphotransferase enzyme family
DIFFNHDI_00029	0.0	-	-	-	T	-	-	-	Chase2 domain
DIFFNHDI_00030	2.34e-107	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
DIFFNHDI_00031	2.7e-113	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_00032	0.0	-	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit I
DIFFNHDI_00033	1.48e-245	-	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit II
DIFFNHDI_00034	0.0	-	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoglutarate dehydrogenase C-terminal
DIFFNHDI_00035	1.47e-229	-	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
DIFFNHDI_00036	8.04e-60	-	3.4.11.5	-	S	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	nucleotidyltransferase activity
DIFFNHDI_00037	5.53e-96	-	-	-	S	-	-	-	Nucleotidyltransferase substrate binding protein like
DIFFNHDI_00038	0.0	-	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
DIFFNHDI_00039	1.9e-312	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
DIFFNHDI_00040	3.85e-159	-	-	-	M	ko:K16079	-	ko00000,ko02000	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DIFFNHDI_00041	0.0	-	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
DIFFNHDI_00042	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
DIFFNHDI_00044	0.0	-	-	-	H	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
DIFFNHDI_00046	0.0	cobQ	-	-	H	-	-	-	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
DIFFNHDI_00047	9.28e-227	cobD	6.3.1.10	-	H	ko:K02227	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DIFFNHDI_00048	4.02e-239	cobT	2.4.2.21	-	H	ko:K00768	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DIFFNHDI_00049	6.59e-172	cobS	2.7.8.26	-	H	ko:K02233	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DIFFNHDI_00050	6.74e-207	-	-	-	G	-	-	-	myo-inosose-2 dehydratase activity
DIFFNHDI_00051	1.82e-126	cobU	2.7.1.156, 2.7.7.62, 6.3.5.10	-	H	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	cobinamide kinase activity
DIFFNHDI_00052	0.0	-	-	-	L	-	-	-	Type III restriction enzyme res subunit
DIFFNHDI_00053	0.0	-	3.1.21.4	-	L	ko:K01155	-	ko00000,ko01000,ko02048	Type III restriction enzyme res subunit
DIFFNHDI_00054	8.79e-263	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
DIFFNHDI_00058	3.61e-268	-	-	-	K	-	-	-	Periplasmic binding protein-like domain
DIFFNHDI_00059	8.21e-215	-	-	-	M	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
DIFFNHDI_00060	3.87e-301	-	2.7.1.11, 2.7.1.90	-	H	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
DIFFNHDI_00062	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_00063	0.0	rarA	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
DIFFNHDI_00064	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
DIFFNHDI_00065	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
DIFFNHDI_00066	7.15e-184	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
DIFFNHDI_00067	6.72e-268	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
DIFFNHDI_00068	0.0	-	4.1.1.19	-	E	ko:K01585	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
DIFFNHDI_00069	7.45e-301	-	4.1.1.96	-	E	ko:K13747	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Pyridoxal-dependent decarboxylase, C-terminal sheet domain
DIFFNHDI_00071	0.0	-	-	-	P	-	-	-	Sulfatase
DIFFNHDI_00072	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Leucyl-tRNA synthetase, Domain 2
DIFFNHDI_00073	1.1e-151	-	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribulose-phosphate 3 epimerase family
DIFFNHDI_00074	1.27e-220	-	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Phosphatidylserine decarboxylase
DIFFNHDI_00075	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
DIFFNHDI_00076	3.88e-140	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
DIFFNHDI_00077	2.34e-43	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S20
DIFFNHDI_00079	1.31e-289	-	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	LytB protein
DIFFNHDI_00080	8.69e-261	-	-	-	J	ko:K05541	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIFFNHDI_00081	4.88e-284	-	-	-	E	-	-	-	Transglutaminase-like superfamily
DIFFNHDI_00082	2.62e-202	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
DIFFNHDI_00083	2.91e-182	-	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
DIFFNHDI_00084	7.21e-203	folD	1.5.1.5, 3.5.4.9	-	H	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DIFFNHDI_00085	7.21e-183	-	-	-	S	ko:K09778	-	ko00000	Domain of unknown function (DUF374)
DIFFNHDI_00086	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00087	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
DIFFNHDI_00088	0.0	-	-	-	G	-	-	-	Alpha amylase, catalytic domain
DIFFNHDI_00089	0.0	-	2.7.7.19	-	J	ko:K00970	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Poly A polymerase head domain
DIFFNHDI_00090	3.39e-311	-	-	-	O	-	-	-	peroxiredoxin activity
DIFFNHDI_00091	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
DIFFNHDI_00092	0.0	-	3.6.4.13	-	L	ko:K03579	-	ko00000,ko01000	ATP-dependent helicase C-terminal
DIFFNHDI_00093	3.14e-213	-	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Cytidylyltransferase family
DIFFNHDI_00095	0.0	-	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	tail specific protease
DIFFNHDI_00096	0.0	-	-	-	E	-	-	-	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DIFFNHDI_00099	3.72e-187	-	3.4.13.22	-	M	ko:K08641	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-ala-D-ala dipeptidase
DIFFNHDI_00100	0.0	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
DIFFNHDI_00101	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
DIFFNHDI_00102	0.0	-	-	-	-	ko:K07403	-	ko00000	-
DIFFNHDI_00103	0.0	-	2.8.4.4	-	J	ko:K14441	-	ko00000,ko01000,ko03009	Uncharacterized protein family UPF0004
DIFFNHDI_00105	0.0	-	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
DIFFNHDI_00106	0.0	pmp21	-	-	T	-	-	-	pathogenesis
DIFFNHDI_00107	7.24e-205	-	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase (PrmA)
DIFFNHDI_00108	1.07e-141	-	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Lumazine binding domain
DIFFNHDI_00109	0.0	-	-	-	P	-	-	-	Putative Na+/H+ antiporter
DIFFNHDI_00110	0.0	-	-	-	G	-	-	-	Polysaccharide deacetylase
DIFFNHDI_00112	4.39e-307	nuoD	1.6.5.3	-	C	ko:K00333	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_00113	2.88e-142	-	1.6.5.3	-	C	ko:K00334	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Thioredoxin-like [2Fe-2S] ferredoxin
DIFFNHDI_00114	0.0	-	1.6.5.3	-	C	ko:K00335	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
DIFFNHDI_00115	0.0	-	1.6.5.3	-	C	ko:K00336	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
DIFFNHDI_00116	1.04e-309	nuoH	1.6.5.3	-	C	ko:K00337	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DIFFNHDI_00117	1.8e-124	nuoI	1.6.5.3	-	C	ko:K00338	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_00118	4.41e-156	-	1.6.5.3	-	C	ko:K00339	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone/plastoquinone oxidoreductase chain 6
DIFFNHDI_00119	6.01e-61	nuoK	1.6.5.3	-	C	ko:K00340	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_00120	0.0	-	1.6.5.3	-	CP	ko:K00341	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
DIFFNHDI_00121	0.0	-	1.6.5.3	-	C	ko:K00342	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Proton-conducting membrane transporter
DIFFNHDI_00122	9.04e-317	nuoN	1.6.5.3	-	C	ko:K00343	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_00123	8.93e-219	-	-	-	E	-	-	-	Domain of unknown function (DUF3472)
DIFFNHDI_00125	7.43e-107	-	-	-	-	-	-	-	-
DIFFNHDI_00126	2.39e-126	-	-	-	S	-	-	-	Pfam:DUF59
DIFFNHDI_00127	0.0	-	5.2.1.8	-	O	ko:K03770	-	ko00000,ko01000,ko03110	PPIC-type PPIASE domain
DIFFNHDI_00128	0.0	-	-	-	E	ko:K03305	-	ko00000	POT family
DIFFNHDI_00129	1.07e-238	-	2.5.1.90	-	H	ko:K02523	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Polyprenyl synthetase
DIFFNHDI_00130	3.77e-288	larC	4.99.1.12	-	S	ko:K09121	-	ko00000,ko01000	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DIFFNHDI_00131	1.39e-190	-	-	-	L	ko:K06864	-	ko00000	tRNA processing
DIFFNHDI_00132	4.2e-171	-	-	-	S	ko:K06898	-	ko00000	AIR carboxylase
DIFFNHDI_00133	0.0	-	-	-	S	-	-	-	Glycosyl hydrolase-like 10
DIFFNHDI_00134	2.89e-156	-	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Iron/manganese superoxide dismutases, alpha-hairpin domain
DIFFNHDI_00135	1.21e-269	-	-	-	IM	-	-	-	Cytidylyltransferase-like
DIFFNHDI_00136	0.0	murJ	-	-	S	ko:K03980	-	ko00000,ko01011,ko02000	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
DIFFNHDI_00137	3.86e-281	-	2.6.1.1	-	E	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
DIFFNHDI_00138	2.83e-110	-	-	-	S	-	-	-	Control of competence regulator ComK, YlbF/YmcA
DIFFNHDI_00139	4.22e-244	-	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIFFNHDI_00140	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
DIFFNHDI_00141	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein E, N-terminal domain
DIFFNHDI_00142	7.26e-285	-	-	-	NU	ko:K02653	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein F
DIFFNHDI_00143	1.34e-07	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
DIFFNHDI_00144	4.12e-225	-	-	-	M	-	-	-	Glycosyl transferase family 2
DIFFNHDI_00145	1.71e-201	-	-	-	S	-	-	-	Glycosyltransferase like family 2
DIFFNHDI_00146	1.3e-104	-	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	NDK
DIFFNHDI_00147	2.16e-188	-	-	-	-	-	-	-	-
DIFFNHDI_00148	1.34e-135	-	5.4.99.20	-	J	ko:K06181	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
DIFFNHDI_00149	4.3e-44	-	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	RNA polymerase activity
DIFFNHDI_00150	1.92e-102	smpB	-	-	O	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
DIFFNHDI_00151	4.12e-139	-	-	-	L	-	-	-	RNase_H superfamily
DIFFNHDI_00152	3.86e-112	-	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
DIFFNHDI_00154	4.28e-274	-	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Citrate synthase, C-terminal domain
DIFFNHDI_00155	3.97e-152	-	-	-	O	-	-	-	Glycoprotease family
DIFFNHDI_00156	1.79e-213	-	-	-	-	-	-	-	-
DIFFNHDI_00159	2.89e-123	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	6-O-methylguanine DNA methyltransferase, DNA binding domain
DIFFNHDI_00161	1.94e-289	-	-	-	C	-	-	-	Iron-containing alcohol dehydrogenase
DIFFNHDI_00162	0.0	-	-	-	S	-	-	-	Alpha-2-macroglobulin family
DIFFNHDI_00163	3.57e-190	dpnC	3.1.21.4	-	L	ko:K01155	-	ko00000,ko01000,ko02048	Dam-replacing family
DIFFNHDI_00164	3.07e-211	MA20_36650	-	-	EG	-	-	-	spore germination
DIFFNHDI_00165	0.0	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
DIFFNHDI_00166	0.0	-	-	-	L	-	-	-	UvrD/REP helicase N-terminal domain
DIFFNHDI_00169	0.0	-	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	Peptidase family M50
DIFFNHDI_00170	6.05e-222	-	-	-	L	-	-	-	Transposase zinc-ribbon domain
DIFFNHDI_00171	1.79e-77	-	-	-	M	-	-	-	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DIFFNHDI_00177	5.25e-79	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DIFFNHDI_00178	2.91e-38	-	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L35
DIFFNHDI_00179	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
DIFFNHDI_00183	7.13e-276	-	-	-	G	-	-	-	Major Facilitator Superfamily
DIFFNHDI_00184	5.49e-85	nuoA	1.6.5.3	-	C	ko:K00330	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_00186	1.32e-195	supH	-	-	Q	-	-	-	phosphatase activity
DIFFNHDI_00187	0.0	legA	3.5.1.2	-	G	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	response to abiotic stimulus
DIFFNHDI_00188	0.0	-	-	-	EG	-	-	-	BNR repeat-like domain
DIFFNHDI_00189	4.49e-187	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
DIFFNHDI_00191	1.15e-188	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
DIFFNHDI_00192	0.0	-	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
DIFFNHDI_00193	1.06e-188	-	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	4Fe-4S single cluster domain
DIFFNHDI_00194	0.0	-	2.3.1.241	-	M	ko:K02517	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Glycosyltransferase family 9 (heptosyltransferase)
DIFFNHDI_00195	1.08e-63	-	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L36
DIFFNHDI_00196	1.6e-293	-	2.3.1.31	-	E	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko01000	alpha/beta hydrolase fold
DIFFNHDI_00197	2.25e-91	-	-	-	O	-	-	-	response to oxidative stress
DIFFNHDI_00198	0.0	-	-	-	T	-	-	-	pathogenesis
DIFFNHDI_00200	1.29e-186	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
DIFFNHDI_00201	2.54e-287	-	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DIFFNHDI_00202	1.7e-154	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	N-(5'phosphoribosyl)anthranilate (PRA) isomerase
DIFFNHDI_00203	9.26e-175	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
DIFFNHDI_00204	0.0	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DIFFNHDI_00205	0.0	-	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Anthranilate synthase component I, N terminal region
DIFFNHDI_00209	0.0	hppA	3.6.1.1	-	C	ko:K15987	ko00190,map00190	ko00000,ko00001,ko01000	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane
DIFFNHDI_00210	4.06e-244	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
DIFFNHDI_00211	3.43e-183	-	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
DIFFNHDI_00212	5.15e-247	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
DIFFNHDI_00213	1.83e-188	-	-	-	-	-	-	-	-
DIFFNHDI_00214	2.01e-157	-	-	-	NU	ko:K02457,ko:K08084	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	protein transport across the cell outer membrane
DIFFNHDI_00216	3.33e-242	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
DIFFNHDI_00217	6.91e-165	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70 region 2
DIFFNHDI_00218	0.0	-	-	-	KT	-	-	-	Sigma factor PP2C-like phosphatases
DIFFNHDI_00219	2.8e-295	-	-	-	EGP	-	-	-	Major facilitator Superfamily
DIFFNHDI_00220	0.0	-	-	-	M	-	-	-	Peptidase M60-like family
DIFFNHDI_00221	1.8e-215	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
DIFFNHDI_00222	3.2e-305	-	-	-	M	-	-	-	OmpA family
DIFFNHDI_00223	1.21e-268	-	-	-	E	-	-	-	serine-type peptidase activity
DIFFNHDI_00224	3.06e-286	-	-	-	S	ko:K11720	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
DIFFNHDI_00225	1.63e-169	-	-	-	S	-	-	-	HAD-hyrolase-like
DIFFNHDI_00227	1.54e-217	-	2.3.1.39	-	I	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Acyl transferase domain
DIFFNHDI_00228	4.19e-87	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
DIFFNHDI_00229	2.95e-262	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DIFFNHDI_00230	2.38e-258	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Possible lysine decarboxylase
DIFFNHDI_00231	1.62e-278	-	3.4.23.43	-	NOU	ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type IV leader peptidase family
DIFFNHDI_00233	0.0	secD	-	-	U	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIFFNHDI_00234	1.96e-226	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
DIFFNHDI_00235	9.03e-173	-	-	-	T	-	-	-	Outer membrane lipoprotein-sorting protein
DIFFNHDI_00236	3.17e-166	-	-	-	S	ko:K05810	-	ko00000,ko01000	Multi-copper polyphenol oxidoreductase laccase
DIFFNHDI_00237	1.12e-217	-	-	-	-	-	-	-	-
DIFFNHDI_00239	5.46e-170	-	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Type I 3-dehydroquinase
DIFFNHDI_00240	3.1e-217	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
DIFFNHDI_00243	3.09e-208	-	-	-	J	ko:K01894	-	ko00000,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), catalytic domain
DIFFNHDI_00244	0.0	-	-	-	P	-	-	-	Citrate transporter
DIFFNHDI_00245	4.39e-145	-	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase homologues.
DIFFNHDI_00246	4.1e-193	-	-	-	S	-	-	-	Domain of unknown function (DUF1732)
DIFFNHDI_00247	0.0	-	2.6.1.66	-	E	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_00250	2.92e-233	-	-	-	CO	-	-	-	Protein of unknown function, DUF255
DIFFNHDI_00251	6.18e-173	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	transporter
DIFFNHDI_00252	2.58e-256	-	-	-	L	-	-	-	Membrane
DIFFNHDI_00253	2.21e-254	-	2.7.1.11, 2.7.1.90	-	G	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Phosphofructokinase
DIFFNHDI_00254	3.37e-224	-	-	-	M	-	-	-	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_00257	2.97e-210	-	1.1.1.262	-	H	ko:K00097	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal phosphate biosynthetic protein PdxA
DIFFNHDI_00258	1.56e-60	-	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S6
DIFFNHDI_00259	1.31e-147	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DIFFNHDI_00260	1.48e-141	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Imidazoleglycerol-phosphate dehydratase
DIFFNHDI_00262	5.05e-131	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DIFFNHDI_00263	4.58e-220	prs	2.7.6.1	-	EF	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DIFFNHDI_00264	1.19e-229	-	-	-	C	-	-	-	Transmembrane exosortase (Exosortase_EpsH)
DIFFNHDI_00265	1.06e-174	-	-	-	S	-	-	-	Protein of unknown function (DUF3485)
DIFFNHDI_00266	5.95e-167	pks6	-	-	Q	-	-	-	amino acid activation for nonribosomal peptide biosynthetic process
DIFFNHDI_00267	6.29e-151	-	-	-	-	-	-	-	-
DIFFNHDI_00268	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
DIFFNHDI_00269	0.0	-	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Peptidase S24-like
DIFFNHDI_00270	2.91e-228	-	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Squalene/phytoene synthase
DIFFNHDI_00271	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
DIFFNHDI_00272	2.96e-242	-	3.1.3.18	-	F	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
DIFFNHDI_00273	4.47e-174	-	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
DIFFNHDI_00274	9.85e-262	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
DIFFNHDI_00275	1.72e-116	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DIFFNHDI_00276	3.65e-60	-	-	-	S	ko:K09131	-	ko00000	DUF167
DIFFNHDI_00277	4.5e-176	-	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidine biosynthesis protein
DIFFNHDI_00279	7.06e-249	-	-	-	-	-	-	-	-
DIFFNHDI_00280	1.14e-126	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
DIFFNHDI_00281	4e-147	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
DIFFNHDI_00282	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	ATPases associated with a variety of cellular activities
DIFFNHDI_00284	7.7e-31	-	-	-	S	ko:K07126	-	ko00000	Sel1-like repeats.
DIFFNHDI_00285	1.44e-110	-	-	-	S	-	-	-	Putative zinc- or iron-chelating domain
DIFFNHDI_00286	3.21e-306	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DIFFNHDI_00287	2.9e-253	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Semialdehyde dehydrogenase, NAD binding domain
DIFFNHDI_00289	0.0	-	-	-	ET	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
DIFFNHDI_00290	8.78e-167	-	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
DIFFNHDI_00291	4.37e-124	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	adenylate kinase activity
DIFFNHDI_00292	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_00293	3.05e-169	-	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
DIFFNHDI_00294	2.51e-191	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
DIFFNHDI_00295	2.94e-155	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
DIFFNHDI_00296	0.0	-	-	-	M	ko:K04744	-	ko00000,ko02000	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DIFFNHDI_00297	0.0	-	-	-	M	-	-	-	NPCBM/NEW2 domain
DIFFNHDI_00298	0.0	-	-	-	G	-	-	-	Glycogen debranching enzyme
DIFFNHDI_00299	1.83e-231	-	1.1.1.37	-	C	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible oxidation of malate to oxaloacetate
DIFFNHDI_00300	0.0	-	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	UDP binding domain
DIFFNHDI_00304	1.33e-100	-	-	-	MP	-	-	-	regulation of cell-substrate adhesion
DIFFNHDI_00308	2.59e-75	-	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
DIFFNHDI_00309	1.16e-241	tilS	6.3.4.19	-	D	ko:K04075	-	ko00000,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
DIFFNHDI_00310	1.4e-259	-	2.3.1.8	-	C	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphate acetyl/butaryl transferase
DIFFNHDI_00311	5.56e-214	-	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	PHP domain
DIFFNHDI_00313	3e-254	-	-	-	S	-	-	-	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
DIFFNHDI_00314	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
DIFFNHDI_00315	2.29e-296	-	-	-	-	-	-	-	-
DIFFNHDI_00316	0.0	-	-	-	L	-	-	-	TRCF
DIFFNHDI_00317	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
DIFFNHDI_00318	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	myo-inosose-2 dehydratase activity
DIFFNHDI_00319	3.67e-236	-	-	-	-	-	-	-	-
DIFFNHDI_00320	3.33e-285	pgk	2.7.2.3	-	G	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglycerate kinase
DIFFNHDI_00321	1.67e-249	-	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
DIFFNHDI_00322	4.46e-148	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
DIFFNHDI_00324	9.65e-133	-	-	-	M	-	-	-	Polysaccharide biosynthesis/export protein
DIFFNHDI_00325	0.0	-	-	-	D	-	-	-	Chain length determinant protein
DIFFNHDI_00326	8.04e-298	-	-	-	-	-	-	-	-
DIFFNHDI_00330	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
DIFFNHDI_00331	5.31e-99	-	-	-	S	-	-	-	peptidase
DIFFNHDI_00332	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
DIFFNHDI_00333	2.2e-61	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DIFFNHDI_00334	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	MreB/Mbl protein
DIFFNHDI_00335	0.0	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
DIFFNHDI_00336	1.14e-279	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
DIFFNHDI_00337	5.1e-241	-	-	-	O	ko:K04655	-	ko00000	AIR synthase related protein, N-terminal domain
DIFFNHDI_00338	1.11e-261	-	-	-	O	ko:K04654	-	ko00000	Hydrogenase formation hypA family
DIFFNHDI_00339	2.74e-50	-	-	-	O	ko:K04653	-	ko00000	HupF/HypC family
DIFFNHDI_00340	0.0	-	-	-	O	ko:K04656	-	ko00000	HypF finger
DIFFNHDI_00341	1.44e-175	hypB	-	-	KO	ko:K04652	-	ko00000,ko03110	CobW/HypB/UreG, nucleotide-binding domain
DIFFNHDI_00342	7.37e-311	-	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Histidyl-tRNA synthetase
DIFFNHDI_00343	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DIFFNHDI_00347	6.65e-261	-	2.3.1.47	-	H	ko:K00652	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_00348	2.33e-281	-	-	-	IQ	-	-	-	Beta-ketoacyl synthase, C-terminal domain
DIFFNHDI_00349	0.0	-	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	thiolester hydrolase activity
DIFFNHDI_00350	3.91e-289	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
DIFFNHDI_00351	5.44e-147	-	-	-	IQ	-	-	-	RmlD substrate binding domain
DIFFNHDI_00352	0.0	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GcpE protein
DIFFNHDI_00353	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
DIFFNHDI_00354	1.51e-198	-	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DIFFNHDI_00355	4.03e-120	-	-	-	-	-	-	-	-
DIFFNHDI_00356	3.85e-194	-	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	CDP-alcohol phosphatidyltransferase
DIFFNHDI_00357	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIFFNHDI_00358	1.37e-227	-	-	-	M	ko:K01993	-	ko00000	HlyD family secretion protein
DIFFNHDI_00359	0.0	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_00360	1.03e-243	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
DIFFNHDI_00361	7.57e-247	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
DIFFNHDI_00368	6.7e-301	nupG	-	-	G	ko:K03289,ko:K03301,ko:K08218,ko:K11537	ko01501,map01501	ko00000,ko00001,ko00002,ko02000	Major facilitator Superfamily
DIFFNHDI_00369	4.16e-259	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIFFNHDI_00370	1.98e-109	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07305,ko:K12267	-	ko00000,ko01000	peptide-methionine (R)-S-oxide reductase activity
DIFFNHDI_00371	3.9e-306	-	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
DIFFNHDI_00373	5.12e-145	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DIFFNHDI_00374	2.37e-46	-	-	-	J	-	-	-	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DIFFNHDI_00375	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00376	0.0	-	-	-	S	-	-	-	Sodium:neurotransmitter symporter family
DIFFNHDI_00377	3.6e-152	-	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
DIFFNHDI_00378	5.98e-211	-	-	-	M	-	-	-	Mechanosensitive ion channel
DIFFNHDI_00379	4.62e-165	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Amino acid kinase family
DIFFNHDI_00380	2.53e-120	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
DIFFNHDI_00381	9.17e-70	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
DIFFNHDI_00396	0.0	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
DIFFNHDI_00397	0.0	-	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
DIFFNHDI_00399	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl tRNA synthetase N terminal dom
DIFFNHDI_00401	1.87e-215	-	-	-	K	-	-	-	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
DIFFNHDI_00402	1.73e-123	paiA	-	-	K	-	-	-	acetyltransferase
DIFFNHDI_00403	5.44e-232	-	-	-	CO	-	-	-	Redoxin
DIFFNHDI_00404	1.12e-83	-	-	-	K	ko:K07343	-	ko00000	positive regulation of type IV pilus biogenesis
DIFFNHDI_00405	2.11e-173	-	6.3.5.11, 6.3.5.9	-	V	ko:K02224,ko:K18554	ko00860,ko01100,ko01120,map00860,map01100,map01120	br01600,ko00000,ko00001,ko01000,ko01504	Chloramphenicol phosphotransferase-like protein
DIFFNHDI_00407	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
DIFFNHDI_00408	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
DIFFNHDI_00409	5e-252	-	2.3.1.1	-	E	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetyltransferase (GNAT) family
DIFFNHDI_00411	2.05e-42	-	-	-	S	-	-	-	Phage terminase large subunit (GpA)
DIFFNHDI_00414	1.05e-19	-	-	-	OU	-	-	-	Belongs to the peptidase S14 family
DIFFNHDI_00431	1.76e-130	-	-	-	S	-	-	-	Glycosyl hydrolase 108
DIFFNHDI_00433	3.8e-80	-	-	-	S	-	-	-	Bacteriophage head to tail connecting protein
DIFFNHDI_00437	6.03e-292	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_00438	2.07e-195	-	-	-	KT	-	-	-	Peptidase S24-like
DIFFNHDI_00440	2.66e-140	-	-	-	M	-	-	-	polygalacturonase activity
DIFFNHDI_00441	1.39e-301	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_00442	3.45e-239	-	1.2.7.3	-	-	ko:K00176,ko:K07138	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	br01601,ko00000,ko00001,ko00002,ko01000	-
DIFFNHDI_00443	1.3e-205	-	-	-	S	-	-	-	Aldo/keto reductase family
DIFFNHDI_00444	2.97e-268	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
DIFFNHDI_00445	4.24e-270	-	-	-	C	-	-	-	Aldo/keto reductase family
DIFFNHDI_00446	8.47e-264	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
DIFFNHDI_00447	9.98e-129	-	-	-	C	-	-	-	FMN binding
DIFFNHDI_00448	7.2e-103	-	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
DIFFNHDI_00449	1.11e-188	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Cupin domain
DIFFNHDI_00450	4.8e-128	-	-	-	S	-	-	-	Flavodoxin-like fold
DIFFNHDI_00451	7.97e-113	-	-	-	K	ko:K13640	-	ko00000,ko03000	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DIFFNHDI_00452	1.65e-102	-	-	-	G	-	-	-	single-species biofilm formation
DIFFNHDI_00453	0.0	-	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
DIFFNHDI_00454	0.0	-	-	-	V	-	-	-	Polysaccharide biosynthesis C-terminal domain
DIFFNHDI_00456	0.0	-	-	-	G	-	-	-	Glycosyl hydrolase family 20, domain 2
DIFFNHDI_00457	1.11e-239	-	4.2.1.113	-	M	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Mandelate Racemase Muconate Lactonizing
DIFFNHDI_00458	3.06e-216	-	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
DIFFNHDI_00459	0.0	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	RNA cap guanine-N2 methyltransferase
DIFFNHDI_00460	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00461	4.7e-57	-	-	-	S	ko:K06960	-	ko00000	KH domain
DIFFNHDI_00462	6.71e-285	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
DIFFNHDI_00463	2.45e-216	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
DIFFNHDI_00466	2.05e-173	-	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	FtsJ-like methyltransferase
DIFFNHDI_00468	1.84e-171	-	-	-	S	ko:K06911	-	ko00000	Pirin
DIFFNHDI_00469	0.0	-	-	-	M	-	-	-	AsmA-like C-terminal region
DIFFNHDI_00471	1.03e-201	-	-	-	G	-	-	-	Class II Aldolase and Adducin N-terminal domain
DIFFNHDI_00472	0.0	-	2.7.1.51	-	G	ko:K00879	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
DIFFNHDI_00474	0.0	fucI	5.3.1.25, 5.3.1.3	-	G	ko:K01818	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Converts the aldose L-fucose into the corresponding ketose L-fuculose
DIFFNHDI_00475	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
DIFFNHDI_00476	1.12e-121	-	-	-	-	-	-	-	-
DIFFNHDI_00477	0.0	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	N-terminal domain of BNR-repeat neuraminidase
DIFFNHDI_00478	2.06e-133	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
DIFFNHDI_00479	7.29e-60	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	negative regulation of transcription, DNA-templated
DIFFNHDI_00480	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
DIFFNHDI_00481	0.0	-	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	ThiC-associated domain
DIFFNHDI_00482	2.19e-220	ytpP	2.7.1.180, 5.3.4.1	-	CO	ko:K01829,ko:K03671,ko:K03734,ko:K06196	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko02000,ko03110	cell redox homeostasis
DIFFNHDI_00483	1.3e-139	-	-	-	K	-	-	-	ECF sigma factor
DIFFNHDI_00485	4.78e-222	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
DIFFNHDI_00486	3.06e-232	-	-	-	O	-	-	-	Parallel beta-helix repeats
DIFFNHDI_00487	0.0	-	3.1.5.1	-	F	ko:K01129	ko00230,map00230	ko00000,ko00001,ko01000	Phosphohydrolase-associated domain
DIFFNHDI_00488	1.95e-284	-	-	-	Q	-	-	-	Multicopper oxidase
DIFFNHDI_00489	1.16e-209	-	-	-	EG	-	-	-	EamA-like transporter family
DIFFNHDI_00491	2.2e-274	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIFFNHDI_00492	6.48e-244	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
DIFFNHDI_00493	9.42e-232	-	-	-	EP	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
DIFFNHDI_00494	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
DIFFNHDI_00495	0.0	-	-	-	P	ko:K13895	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_00496	0.0	-	-	-	EP	ko:K13894	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_00497	1.4e-185	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
DIFFNHDI_00498	1.35e-207	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_00499	9.98e-223	-	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Ketopantoate reductase PanE/ApbA C terminal
DIFFNHDI_00500	0.0	fhs	6.3.4.3	-	H	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Formate--tetrahydrofolate ligase
DIFFNHDI_00501	5.77e-145	-	-	-	S	ko:K09974	-	ko00000	Domain of unknown function (DUF1287)
DIFFNHDI_00502	8.95e-316	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
DIFFNHDI_00503	3.77e-118	-	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
DIFFNHDI_00504	2.52e-281	-	5.4.99.22	-	M	ko:K06178	-	ko00000,ko01000,ko03009	translation initiation factor activity
DIFFNHDI_00505	1.27e-133	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
DIFFNHDI_00506	7.4e-93	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
DIFFNHDI_00507	8.02e-130	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
DIFFNHDI_00508	8.59e-293	-	3.2.1.1	GH57	G	ko:K07405	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolase family 57
DIFFNHDI_00509	1.25e-315	-	-	-	G	-	-	-	Glycosyl transferase 4-like domain
DIFFNHDI_00510	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 31
DIFFNHDI_00511	6.05e-250	-	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	chorismate binding enzyme
DIFFNHDI_00512	3.89e-313	-	-	-	C	ko:K00185	-	ko00000	Polysulphide reductase, NrfD
DIFFNHDI_00514	7.47e-156	-	-	-	C	-	-	-	Cytochrome c
DIFFNHDI_00515	4.3e-296	-	-	-	P	-	-	-	ABC-type Zn2 transport system, periplasmic component surface adhesin
DIFFNHDI_00516	0.0	-	-	-	C	-	-	-	Cytochrome c
DIFFNHDI_00518	1.38e-60	-	-	-	E	ko:K07032	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
DIFFNHDI_00519	1.13e-270	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
DIFFNHDI_00520	6.74e-307	-	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate/isopropylmalate dehydrogenase
DIFFNHDI_00521	1.05e-160	-	-	-	S	-	-	-	Protein of unknown function (DUF4230)
DIFFNHDI_00522	2.48e-62	-	-	-	S	-	-	-	Protein of unknown function (DUF1232)
DIFFNHDI_00523	0.0	-	-	-	J	-	-	-	Beta-Casp domain
DIFFNHDI_00524	4.02e-144	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DIFFNHDI_00525	1.02e-159	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Queuosine biosynthesis protein QueC
DIFFNHDI_00526	1.78e-97	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	QueF-like protein
DIFFNHDI_00527	0.0	kefA	-	-	M	ko:K05802,ko:K22051	-	ko00000,ko02000	cellular water homeostasis
DIFFNHDI_00528	0.0	gltX	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DIFFNHDI_00529	7.46e-238	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DIFFNHDI_00530	1.44e-191	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Bacitracin resistance protein BacA
DIFFNHDI_00533	1.05e-84	-	-	-	S	ko:K06940	-	ko00000	Putative zinc- or iron-chelating domain
DIFFNHDI_00534	4.68e-315	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
DIFFNHDI_00536	1.65e-303	-	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
DIFFNHDI_00537	1.33e-52	-	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
DIFFNHDI_00538	4.17e-260	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DIFFNHDI_00540	8.29e-100	cysJ	1.8.1.2	-	C	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	hydroxylamine reductase activity
DIFFNHDI_00542	5.74e-200	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
DIFFNHDI_00543	1.06e-169	BT0174	-	-	C	ko:K04488	-	ko00000	iron-sulfur transferase activity
DIFFNHDI_00544	2.08e-240	BT0173	-	-	S	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_00546	7.78e-269	-	2.1.1.72	-	H	ko:K07318	-	ko00000,ko01000,ko02048	PFAM D12 class N6 adenine-specific DNA methyltransferase
DIFFNHDI_00547	6.72e-210	-	-	-	L	ko:K04763	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
DIFFNHDI_00552	3.48e-274	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Iron-containing alcohol dehydrogenase
DIFFNHDI_00553	6.02e-78	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIFFNHDI_00554	2.49e-229	-	-	-	G	-	-	-	pfkB family carbohydrate kinase
DIFFNHDI_00555	0.0	fabZ	3.5.1.108, 4.2.1.59	-	IM	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
DIFFNHDI_00556	4.66e-230	-	2.7.7.13	-	JM	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
DIFFNHDI_00557	4.47e-176	-	-	-	S	-	-	-	Phosphodiester glycosidase
DIFFNHDI_00558	0.0	-	-	GT2	M	ko:K03820	-	ko00000,ko01000	Carbon-nitrogen hydrolase
DIFFNHDI_00559	1.33e-51	-	-	-	C	-	-	-	4Fe-4S single cluster domain of Ferredoxin I
DIFFNHDI_00560	1.12e-103	-	-	-	S	-	-	-	Protein of unknown function (DUF721)
DIFFNHDI_00561	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
DIFFNHDI_00562	2.52e-237	-	-	-	S	-	-	-	Acyltransferase family
DIFFNHDI_00563	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
DIFFNHDI_00564	2.69e-185	ccs1	-	-	O	ko:K07399	-	ko00000	cytochrome c biogenesis protein
DIFFNHDI_00565	2.42e-209	fatB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion transport
DIFFNHDI_00566	1.06e-180	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
DIFFNHDI_00567	1.23e-228	fatC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
DIFFNHDI_00568	4.39e-219	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
DIFFNHDI_00569	2.43e-264	-	-	-	J	-	-	-	Endoribonuclease L-PSP
DIFFNHDI_00570	0.0	-	-	-	C	-	-	-	Di-haem oxidoreductase, putative peroxidase
DIFFNHDI_00571	7.56e-246	-	-	-	S	-	-	-	Imelysin
DIFFNHDI_00572	6.48e-142	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
DIFFNHDI_00574	1.82e-125	-	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Phosphoribosyl transferase domain
DIFFNHDI_00575	0.0	-	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	Helix-hairpin-helix class 2 (Pol1 family) motifs
DIFFNHDI_00576	1.37e-249	-	-	-	M	-	-	-	HlyD family secretion protein
DIFFNHDI_00577	1.78e-102	MA20_05485	-	-	S	-	-	-	Putative bacterial sensory transduction regulator
DIFFNHDI_00578	0.0	-	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminus
DIFFNHDI_00579	1.46e-302	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
DIFFNHDI_00580	0.0	-	-	-	D	-	-	-	Tetratricopeptide repeat
DIFFNHDI_00581	1.47e-193	-	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
DIFFNHDI_00582	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00583	6.55e-222	-	4.1.3.3	-	EM	ko:K01639	ko00520,map00520	ko00000,ko00001,ko01000	Dihydrodipicolinate synthetase family
DIFFNHDI_00584	6.68e-314	-	5.1.3.8	-	G	ko:K01787	ko00520,map00520	ko00000,ko00001,ko01000	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
DIFFNHDI_00585	0.0	-	-	-	S	-	-	-	Protein of unknown function DUF262
DIFFNHDI_00586	5.32e-148	-	4.1.3.38	-	E	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	branched-chain-amino-acid transaminase activity
DIFFNHDI_00587	1.04e-246	pabB	2.6.1.85, 4.1.3.27, 4.1.3.38	-	EH	ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DIFFNHDI_00588	2.09e-150	-	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Peptidase C26
DIFFNHDI_00589	4.49e-269	-	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
DIFFNHDI_00591	2.5e-170	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
DIFFNHDI_00592	2.11e-118	-	-	-	T	ko:K07005	-	ko00000	pyridoxamine 5'-phosphate
DIFFNHDI_00593	7.17e-172	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Glutamine amidotransferase class-I
DIFFNHDI_00595	2.87e-112	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Cys-tRNA(Pro) hydrolase activity
DIFFNHDI_00596	0.0	mmyX	5.3.1.12	-	F	ko:K01812,ko:K07149,ko:K16139	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000,ko02000	Psort location Cytoplasmic, score
DIFFNHDI_00597	6.74e-106	-	-	-	-	-	-	-	-
DIFFNHDI_00600	4.37e-147	-	-	-	Q	-	-	-	PA14
DIFFNHDI_00602	0.0	-	2.1.1.13	-	E	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	B12 binding domain
DIFFNHDI_00603	1.66e-171	-	-	-	S	-	-	-	Putative threonine/serine exporter
DIFFNHDI_00604	1.45e-102	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
DIFFNHDI_00605	2.9e-315	-	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system DNA methylase K03427
DIFFNHDI_00606	2.53e-81	-	3.1.21.3	-	L	ko:K01154	-	ko00000,ko01000,ko02048	type I restriction modification DNA specificity domain
DIFFNHDI_00607	2.19e-10	-	3.1.21.3	-	L	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
DIFFNHDI_00608	0.0	-	-	-	CO	-	-	-	Thioredoxin-like
DIFFNHDI_00613	3.35e-116	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DIFFNHDI_00614	0.0	-	-	-	S	ko:K07037	-	ko00000	7TM receptor with intracellular HD hydrolase
DIFFNHDI_00615	1.22e-246	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
DIFFNHDI_00616	2.73e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
DIFFNHDI_00617	4.98e-117	-	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
DIFFNHDI_00618	1.16e-78	-	-	-	FG	ko:K02503	-	ko00000,ko04147	HIT domain
DIFFNHDI_00619	6.97e-241	-	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
DIFFNHDI_00620	1.55e-128	aroK	2.7.1.71	-	E	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DIFFNHDI_00621	9.56e-51	-	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S16
DIFFNHDI_00623	1.03e-14	-	-	-	E	-	-	-	LysE type translocator
DIFFNHDI_00624	1.31e-214	-	-	-	L	ko:K03733	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
DIFFNHDI_00625	6.5e-186	-	-	-	DTZ	-	-	-	EF-hand, calcium binding motif
DIFFNHDI_00626	5.64e-66	-	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit
DIFFNHDI_00627	1.39e-282	tgt	2.4.2.29	-	J	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
DIFFNHDI_00628	1.42e-149	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Putative methyltransferase
DIFFNHDI_00629	4.32e-174	-	-	-	F	-	-	-	NUDIX domain
DIFFNHDI_00630	5.96e-127	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
DIFFNHDI_00631	1.71e-207	-	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
DIFFNHDI_00632	1.9e-62	-	-	-	L	-	-	-	bacterial (prokaryotic) histone like domain
DIFFNHDI_00638	1.67e-141	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
DIFFNHDI_00639	3.02e-170	-	2.5.1.39	-	H	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DIFFNHDI_00640	3.33e-254	-	5.2.1.8	-	O	ko:K03771	-	ko00000,ko01000,ko03110	SurA N-terminal domain
DIFFNHDI_00641	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Domain of unknown function (DUF4982)
DIFFNHDI_00642	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
DIFFNHDI_00643	6.2e-203	-	-	-	-	-	-	-	-
DIFFNHDI_00644	6.79e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DIFFNHDI_00645	2.19e-56	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DIFFNHDI_00646	2.36e-34	-	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L29 protein
DIFFNHDI_00647	3.42e-97	-	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DIFFNHDI_00648	5.2e-156	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DIFFNHDI_00649	4.97e-70	-	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
DIFFNHDI_00650	4.05e-152	-	-	-	-	-	-	-	-
DIFFNHDI_00651	1.05e-58	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DIFFNHDI_00652	1.85e-203	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DIFFNHDI_00653	8.72e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
DIFFNHDI_00654	1.9e-131	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L4/L1 family
DIFFNHDI_00655	3.86e-149	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DIFFNHDI_00656	3.67e-65	-	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S10p/S20e
DIFFNHDI_00657	0.0	-	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DIFFNHDI_00658	2.91e-104	-	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S7p/S5e
DIFFNHDI_00659	4.16e-85	-	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S12/S23
DIFFNHDI_00660	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	BPG-independent PGAM N-terminus (iPGM_N)
DIFFNHDI_00661	3.37e-97	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase superfamily
DIFFNHDI_00662	1.82e-274	-	-	-	T	-	-	-	PAS domain
DIFFNHDI_00663	0.0	-	-	-	T	-	-	-	Bacterial regulatory protein, Fis family
DIFFNHDI_00664	0.0	-	-	-	O	-	-	-	C-terminal four TMM region of protein-O-mannosyltransferase
DIFFNHDI_00665	3.08e-52	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease VII activity
DIFFNHDI_00666	0.0	dxs	2.2.1.7	-	HI	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DIFFNHDI_00667	3.99e-183	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_00668	2.31e-127	-	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Recombination protein O N terminal
DIFFNHDI_00669	9.67e-251	-	-	-	S	ko:K07091	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
DIFFNHDI_00670	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal
DIFFNHDI_00671	2.05e-229	-	-	-	EP	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
DIFFNHDI_00672	3.07e-155	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	Chloramphenicol acetyltransferase
DIFFNHDI_00674	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
DIFFNHDI_00675	4.97e-168	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_00676	0.0	-	-	-	P	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
DIFFNHDI_00677	2.52e-205	-	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydrogenase
DIFFNHDI_00679	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
DIFFNHDI_00680	3.42e-111	-	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	Cytidine and deoxycytidylate deaminase zinc-binding region
DIFFNHDI_00682	1.86e-94	-	-	-	O	-	-	-	OsmC-like protein
DIFFNHDI_00683	0.0	-	-	-	CO	-	-	-	Disulphide bond corrector protein DsbC
DIFFNHDI_00684	1.14e-175	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
DIFFNHDI_00685	7.58e-140	-	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Exonuclease
DIFFNHDI_00686	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DIFFNHDI_00687	4.69e-79	rsfS	-	-	S	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
DIFFNHDI_00688	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIFFNHDI_00690	6.38e-258	-	-	-	S	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
DIFFNHDI_00691	4.36e-200	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Enoyl-CoA hydratase/isomerase
DIFFNHDI_00694	1.85e-302	-	-	-	MU	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	efflux transmembrane transporter activity
DIFFNHDI_00698	9.85e-147	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
DIFFNHDI_00701	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
DIFFNHDI_00702	8.38e-98	-	-	-	-	-	-	-	-
DIFFNHDI_00703	3.14e-192	-	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
DIFFNHDI_00704	0.0	-	-	-	S	-	-	-	Fungal chitosanase of glycosyl hydrolase group 75
DIFFNHDI_00705	9.68e-221	-	2.5.1.21	-	I	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01006	Squalene/phytoene synthase
DIFFNHDI_00706	0.0	-	-	-	KT	ko:K02584	ko02020,map02020	ko00000,ko00001,ko03000	Bacterial regulatory protein, Fis family
DIFFNHDI_00707	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
DIFFNHDI_00709	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_00711	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00712	0.0	-	4.1.1.15	-	E	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase conserved domain
DIFFNHDI_00713	5.21e-142	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
DIFFNHDI_00714	0.0	-	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase alpha chain like domain
DIFFNHDI_00715	4.25e-238	pyrD	1.3.5.2	-	F	ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroorotate dehydrogenase
DIFFNHDI_00716	4.7e-156	-	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Thiamine monophosphate synthase
DIFFNHDI_00717	1.1e-159	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
DIFFNHDI_00718	1.63e-164	-	-	-	CO	-	-	-	Thioredoxin-like
DIFFNHDI_00719	0.0	-	-	-	C	-	-	-	Cytochrome c554 and c-prime
DIFFNHDI_00720	3.4e-311	-	-	-	S	-	-	-	PFAM CBS domain containing protein
DIFFNHDI_00721	9.05e-313	tlyC	-	-	S	ko:K03699	-	ko00000,ko02042	PFAM CBS domain containing protein
DIFFNHDI_00722	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
DIFFNHDI_00723	3.01e-49	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal_S15
DIFFNHDI_00724	2.32e-151	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
DIFFNHDI_00725	2.46e-215	-	-	-	D	ko:K19234,ko:K19236	ko01503,map01503	ko00000,ko00001,ko01002,ko01011	ErfK ybiS ycfS ynhG family protein
DIFFNHDI_00726	0.0	-	-	-	S	-	-	-	Terminase
DIFFNHDI_00729	7.54e-201	-	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
DIFFNHDI_00730	1.04e-144	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DIFFNHDI_00731	9.86e-168	-	-	-	M	-	-	-	Peptidase family M23
DIFFNHDI_00732	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	PFAM coagulation factor 5 8 type domain protein
DIFFNHDI_00734	1.33e-174	-	-	-	NU	-	-	-	Prepilin-type N-terminal cleavage methylation domain
DIFFNHDI_00735	1.16e-178	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DIFFNHDI_00736	0.0	-	-	-	S	-	-	-	Type I phosphodiesterase / nucleotide pyrophosphatase
DIFFNHDI_00737	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
DIFFNHDI_00738	6.94e-153	-	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	AAA domain
DIFFNHDI_00740	4.86e-201	-	-	-	S	-	-	-	DisA bacterial checkpoint controller nucleotide-binding
DIFFNHDI_00741	6.25e-144	-	-	-	-	-	-	-	-
DIFFNHDI_00742	6.38e-151	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_00743	3.42e-196	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DIFFNHDI_00744	1.48e-120	-	-	-	M	ko:K06142	-	ko00000	Outer membrane protein (OmpH-like)
DIFFNHDI_00745	5.68e-188	lpxD	2.3.1.191	-	M	ko:K02536	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIFFNHDI_00746	1.2e-196	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_00747	5.69e-190	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_00748	6.06e-251	-	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	NMT1/THI5 like
DIFFNHDI_00750	4.48e-223	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
DIFFNHDI_00751	6.23e-118	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Polynucleotide kinase 3 phosphatase
DIFFNHDI_00752	8.25e-131	-	5.3.1.28	-	G	ko:K03271	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
DIFFNHDI_00753	0.0	-	2.7.1.167, 2.7.7.70	-	M	ko:K03272	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	pfkB family carbohydrate kinase
DIFFNHDI_00754	1.06e-44	-	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S21
DIFFNHDI_00755	1.05e-311	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
DIFFNHDI_00756	5.67e-258	-	-	-	S	-	-	-	ankyrin repeats
DIFFNHDI_00757	0.0	-	-	-	EGP	-	-	-	Sugar (and other) transporter
DIFFNHDI_00758	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00759	0.0	glnS	6.1.1.18	-	J	ko:K01886	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), anti-codon binding domain
DIFFNHDI_00760	9.59e-288	-	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase II
DIFFNHDI_00761	8.55e-104	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
DIFFNHDI_00762	8.13e-206	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIFFNHDI_00763	1.1e-197	-	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SRP54-type protein, GTPase domain
DIFFNHDI_00764	6.16e-261	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Elongator protein 3, MiaB family, Radical SAM
DIFFNHDI_00765	0.0	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
DIFFNHDI_00766	1.6e-182	-	-	-	U	ko:K20276	ko02024,map02024	ko00000,ko00001	domain, Protein
DIFFNHDI_00767	5.7e-153	-	-	-	O	-	-	-	methyltransferase activity
DIFFNHDI_00768	7.21e-290	-	3.5.1.42	-	S	ko:K03742	ko00760,map00760	ko00000,ko00001,ko01000	Competence-damaged protein
DIFFNHDI_00769	0.0	-	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Pyruvate kinase, barrel domain
DIFFNHDI_00770	4.37e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
DIFFNHDI_00774	4.02e-191	-	-	-	E	-	-	-	haloacid dehalogenase-like hydrolase
DIFFNHDI_00775	4.36e-142	-	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S4/S9 N-terminal domain
DIFFNHDI_00776	2.11e-121	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DIFFNHDI_00777	1.11e-79	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DIFFNHDI_00778	1.59e-269	-	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Domain of unknown function (DUF1730)
DIFFNHDI_00779	1.18e-224	-	-	-	M	ko:K07276	-	ko00000	Mitochondrial fission ELM1
DIFFNHDI_00780	1.21e-268	-	-	-	M	-	-	-	Glycosyl transferase 4-like
DIFFNHDI_00781	6.26e-269	-	-	-	LU	ko:K04096	-	ko00000	DNA recombination-mediator protein A
DIFFNHDI_00782	9.59e-216	-	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_00783	1.11e-261	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
DIFFNHDI_00784	2.85e-267	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Aminomethyltransferase folate-binding domain
DIFFNHDI_00785	6.67e-86	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
DIFFNHDI_00786	0.0	gcvP	1.4.4.2	-	E	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DIFFNHDI_00788	6.18e-150	-	-	-	L	-	-	-	Membrane
DIFFNHDI_00789	0.0	-	-	-	P	ko:K01138	-	ko00000,ko01000	PA14 domain
DIFFNHDI_00790	0.0	-	3.6.4.13	-	L	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DbpA RNA binding domain
DIFFNHDI_00791	1.02e-174	-	-	-	-	-	-	-	-
DIFFNHDI_00792	0.0	-	3.1.1.53	-	E	ko:K05970	-	ko00000,ko01000	Carbohydrate esterase, sialic acid-specific acetylesterase
DIFFNHDI_00793	9.94e-243	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
DIFFNHDI_00794	5.94e-235	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
DIFFNHDI_00795	3.78e-248	-	-	-	M	-	-	-	Glycosyl transferase, family 2
DIFFNHDI_00796	1.27e-207	MA20_42350	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	Glycosyl transferase, family 2
DIFFNHDI_00797	1.83e-282	-	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	FAD binding domain
DIFFNHDI_00798	9.5e-239	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIFFNHDI_00799	3.4e-243	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
DIFFNHDI_00803	1.7e-13	-	-	-	K	-	-	-	Restriction-modification system regulatory protein
DIFFNHDI_00809	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
DIFFNHDI_00810	0.0	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	BNR/Asp-box repeat
DIFFNHDI_00811	8.38e-276	-	-	-	K	-	-	-	Periplasmic binding protein-like domain
DIFFNHDI_00812	0.0	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	exo-alpha-(2->6)-sialidase activity
DIFFNHDI_00814	2.28e-79	-	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
DIFFNHDI_00815	0.0	-	6.3.5.1	-	H	ko:K01950	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	NAD synthase
DIFFNHDI_00816	7.18e-182	-	-	-	Q	-	-	-	methyltransferase activity
DIFFNHDI_00818	3.15e-137	-	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	Serine/threonine phosphatases, family 2C, catalytic domain
DIFFNHDI_00819	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
DIFFNHDI_00820	6.13e-194	-	-	-	-	-	-	-	-
DIFFNHDI_00821	4.91e-121	-	3.2.2.28	-	L	ko:K03649	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	G/U mismatch-specific uracil-DNA glycosylase activity
DIFFNHDI_00822	3.12e-224	-	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
DIFFNHDI_00823	2.88e-116	hisI	3.5.4.19	-	E	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Phosphoribosyl-AMP cyclohydrolase
DIFFNHDI_00824	1.18e-170	-	-	-	S	ko:K05807	-	ko00000,ko02000	Outer membrane lipoprotein
DIFFNHDI_00825	7.51e-116	-	-	-	S	-	-	-	Lipopolysaccharide-assembly
DIFFNHDI_00826	4.14e-164	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Tetrapyrrole (Corrin/Porphyrin) Methylases
DIFFNHDI_00827	3.23e-182	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
DIFFNHDI_00828	2.72e-18	-	-	-	-	-	-	-	-
DIFFNHDI_00829	0.0	-	-	-	P	ko:K07221	-	ko00000,ko02000	Phosphate-selective porin O and P
DIFFNHDI_00830	3.86e-162	rnc	3.1.26.3	-	K	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
DIFFNHDI_00831	1.53e-120	actI	1.5.1.36	-	S	ko:K00484	ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220	ko00000,ko00001,ko01000	FMN binding
DIFFNHDI_00832	1.57e-259	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DIFFNHDI_00833	8.17e-147	-	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Phosphate acyltransferases
DIFFNHDI_00834	2.3e-142	-	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Cytidylate kinase
DIFFNHDI_00835	0.0	-	-	-	I	-	-	-	Acetyltransferase (GNAT) domain
DIFFNHDI_00836	1.21e-209	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DIFFNHDI_00837	4.34e-202	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
DIFFNHDI_00838	0.0	-	-	-	GK	-	-	-	carbohydrate kinase activity
DIFFNHDI_00839	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
DIFFNHDI_00841	2.66e-290	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIFFNHDI_00842	3.36e-130	-	-	-	D	ko:K06287	-	ko00000	Maf-like protein
DIFFNHDI_00843	0.0	-	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
DIFFNHDI_00845	0.0	-	-	-	T	-	-	-	pathogenesis
DIFFNHDI_00846	5.39e-136	-	-	-	F	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
DIFFNHDI_00847	8.36e-174	-	-	-	S	-	-	-	peptidoglycan biosynthetic process
DIFFNHDI_00848	6.18e-205	-	1.4.1.16	-	S	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
DIFFNHDI_00850	0.000103	-	-	-	S	-	-	-	Entericidin EcnA/B family
DIFFNHDI_00851	1.99e-233	-	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	prohibitin homologues
DIFFNHDI_00852	2.13e-118	-	-	-	-	-	-	-	-
DIFFNHDI_00853	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
DIFFNHDI_00854	2.22e-298	lpxK	2.7.1.130	-	M	ko:K00912	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
DIFFNHDI_00855	1.94e-140	-	-	-	S	ko:K07164	-	ko00000	C4-type zinc ribbon domain
DIFFNHDI_00856	2.24e-264	-	3.1.13.5	-	J	ko:K03684	-	ko00000,ko01000,ko03016	3'-5' exonuclease
DIFFNHDI_00857	3.03e-74	-	-	-	-	-	-	-	-
DIFFNHDI_00858	1.97e-189	-	3.6.1.66	-	S	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	MazG nucleotide pyrophosphohydrolase domain
DIFFNHDI_00859	2.92e-70	-	-	-	-	-	-	-	-
DIFFNHDI_00860	2.51e-182	-	-	-	S	-	-	-	competence protein
DIFFNHDI_00861	6.79e-100	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
DIFFNHDI_00864	0.0	-	3.1.6.1	-	P	ko:K01130	ko00140,ko00600,map00140,map00600	ko00000,ko00001,ko01000	Sulfatase
DIFFNHDI_00865	2.63e-143	-	-	-	-	-	-	-	-
DIFFNHDI_00866	1.06e-163	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
DIFFNHDI_00867	4.82e-178	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
DIFFNHDI_00868	2.6e-298	-	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	16S rRNA methyltransferase RsmB/F
DIFFNHDI_00869	9.36e-114	-	3.1.6.8	-	P	ko:K01134	ko00600,ko04142,map00600,map04142	ko00000,ko00001,ko01000	COG3119 Arylsulfatase A
DIFFNHDI_00870	2.9e-316	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Arginosuccinate synthase
DIFFNHDI_00872	2.79e-54	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DIFFNHDI_00873	8.43e-59	-	-	-	S	-	-	-	Zinc ribbon domain
DIFFNHDI_00874	4.77e-310	-	-	-	S	-	-	-	PFAM CBS domain containing protein
DIFFNHDI_00875	2.51e-151	-	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
DIFFNHDI_00876	4.83e-82	-	-	-	L	ko:K07460	-	ko00000	Uncharacterised protein family UPF0102
DIFFNHDI_00878	1.67e-177	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
DIFFNHDI_00879	3.4e-229	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
DIFFNHDI_00880	1.39e-157	-	-	-	S	-	-	-	3D domain
DIFFNHDI_00881	2.15e-151	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DIFFNHDI_00882	9.91e-171	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
DIFFNHDI_00883	1.65e-113	aglS	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
DIFFNHDI_00884	4.52e-101	exbD2	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
DIFFNHDI_00886	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_00887	5.47e-195	-	-	-	-	-	-	-	-
DIFFNHDI_00888	8.99e-277	-	-	-	K	-	-	-	sequence-specific DNA binding
DIFFNHDI_00889	0.0	-	-	-	J	ko:K08301	-	ko00000,ko01000,ko03009,ko03019	Ribonuclease E/G family
DIFFNHDI_00890	5.06e-236	-	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Actin
DIFFNHDI_00891	0.0	lacZ_17	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
DIFFNHDI_00893	2.24e-263	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
DIFFNHDI_00895	7.5e-177	-	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	CobB/CobQ-like glutamine amidotransferase domain
DIFFNHDI_00896	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
DIFFNHDI_00897	2.26e-115	-	-	-	-	-	-	-	-
DIFFNHDI_00898	1.89e-166	-	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	SAICAR synthetase
DIFFNHDI_00899	0.0	-	-	-	K	-	-	-	Transcription elongation factor, N-terminal
DIFFNHDI_00900	0.0	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DIFFNHDI_00901	1.05e-180	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DIFFNHDI_00902	6.75e-305	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DIFFNHDI_00903	1.34e-201	-	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase, N-terminal
DIFFNHDI_00904	1.06e-109	-	-	-	S	ko:K15977	-	ko00000	DoxX
DIFFNHDI_00905	2.76e-292	-	4.2.1.129, 5.4.99.17	-	I	ko:K06045	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
DIFFNHDI_00906	4.7e-193	-	-	-	-	-	-	-	-
DIFFNHDI_00907	1.18e-224	-	5.3.1.13	-	M	ko:K06041	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
DIFFNHDI_00908	9.39e-183	-	-	-	H	-	-	-	ThiF family
DIFFNHDI_00909	3.67e-126	-	-	-	U	-	-	-	response to pH
DIFFNHDI_00910	2.89e-223	-	-	-	-	-	-	-	-
DIFFNHDI_00911	4.09e-218	-	-	-	I	-	-	-	alpha/beta hydrolase fold
DIFFNHDI_00913	0.0	-	-	-	G	-	-	-	Raffinose synthase or seed imbibition protein Sip1
DIFFNHDI_00914	3.11e-271	-	-	-	S	-	-	-	COGs COG4299 conserved
DIFFNHDI_00915	5.1e-153	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_00916	0.0	-	3.4.16.4	-	M	ko:K05515	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein dimerisation domain
DIFFNHDI_00917	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00918	6.27e-219	-	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	ATP synthase A chain
DIFFNHDI_00919	1.65e-11	-	-	-	S	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	PFAM H transporting two-sector ATPase C subunit
DIFFNHDI_00920	4.38e-78	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase B/B' CF(0)
DIFFNHDI_00921	6.46e-86	-	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase delta (OSCP) subunit
DIFFNHDI_00922	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DIFFNHDI_00923	4.5e-201	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DIFFNHDI_00924	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DIFFNHDI_00925	1.24e-90	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
DIFFNHDI_00926	1.38e-139	-	-	-	-	-	-	-	-
DIFFNHDI_00927	8.17e-124	sprT	-	-	K	-	-	-	SprT-like family
DIFFNHDI_00928	4.27e-275	-	-	-	S	-	-	-	COGs COG4299 conserved
DIFFNHDI_00929	7.67e-285	-	2.6.1.59	-	M	ko:K02805	-	ko00000,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
DIFFNHDI_00930	4.94e-114	flmH	2.3.1.57	-	J	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIFFNHDI_00931	7.63e-220	-	-	-	M	-	-	-	Glycosyl transferase family 2
DIFFNHDI_00932	1.08e-73	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
DIFFNHDI_00933	1.85e-75	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
DIFFNHDI_00936	0.0	-	2.6.1.62	-	H	ko:K00833	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
DIFFNHDI_00937	2.93e-233	-	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Biotin and Thiamin Synthesis associated domain
DIFFNHDI_00938	0.0	-	-	-	P	-	-	-	Sulfatase
DIFFNHDI_00939	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
DIFFNHDI_00940	2.6e-296	-	-	-	O	ko:K09015	-	ko00000	Uncharacterized protein family (UPF0051)
DIFFNHDI_00941	0.0	-	-	-	O	ko:K09014	-	ko00000	Uncharacterized protein family (UPF0051)
DIFFNHDI_00942	8.34e-178	-	-	-	O	ko:K09013	-	ko00000,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_00943	6.78e-100	-	-	-	P	ko:K09825	-	ko00000,ko03000	Ferric uptake regulator family
DIFFNHDI_00944	2.14e-57	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L27 protein
DIFFNHDI_00945	1.93e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal prokaryotic L21 protein
DIFFNHDI_00946	1.65e-106	-	-	-	S	ko:K06925	-	ko00000,ko03016	Threonylcarbamoyl adenosine biosynthesis protein TsaE
DIFFNHDI_00947	1.07e-199	-	-	-	S	ko:K06889	-	ko00000	alpha beta
DIFFNHDI_00949	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
DIFFNHDI_00950	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_00951	2.58e-225	-	-	-	S	-	-	-	Polyphosphate kinase 2 (PPK2)
DIFFNHDI_00953	1.36e-175	-	-	-	-	-	-	-	-
DIFFNHDI_00954	3.35e-131	-	-	-	L	-	-	-	Conserved hypothetical protein 95
DIFFNHDI_00955	1.18e-309	-	2.4.99.12, 2.4.99.13, 2.4.99.14, 2.4.99.15	GT30	M	ko:K02527	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)
DIFFNHDI_00956	9.68e-226	-	-	-	S	-	-	-	Aspartyl protease
DIFFNHDI_00957	1.67e-272	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
DIFFNHDI_00958	2.4e-160	-	6.3.2.5	-	H	ko:K21977	ko00770,map00770	ko00000,ko00001,ko00002,ko01000	DNA / pantothenate metabolism flavoprotein
DIFFNHDI_00959	9.7e-279	-	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class-V
DIFFNHDI_00960	1.94e-104	-	-	-	K	ko:K03826	-	ko00000,ko01000	acetyltransferase
DIFFNHDI_00961	2.48e-173	-	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
DIFFNHDI_00962	0.0	-	-	-	L	-	-	-	Polyphosphate kinase 2 (PPK2)
DIFFNHDI_00963	0.0	-	-	-	S	-	-	-	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DIFFNHDI_00964	2.31e-259	-	-	-	M	-	-	-	Peptidase family M23
DIFFNHDI_00966	8.37e-126	-	4.1.1.36	-	H	ko:K01598	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Flavoprotein
DIFFNHDI_00967	1.31e-81	-	-	-	DJ	-	-	-	Addiction module toxin, RelE StbE family
DIFFNHDI_00968	2.34e-208	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
DIFFNHDI_00970	1.26e-139	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
DIFFNHDI_00971	0.0	-	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DIFFNHDI_00972	4.75e-245	-	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR synthase related protein, N-terminal domain
DIFFNHDI_00973	1.84e-105	-	-	-	S	ko:K15977	-	ko00000	DoxX
DIFFNHDI_00974	7.7e-126	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_00976	4.14e-67	-	-	-	M	-	-	-	self proteolysis
DIFFNHDI_00977	1.24e-39	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_00979	2.1e-103	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_00984	2.42e-54	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_00986	1.13e-110	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_00992	5.46e-22	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	HMGL-like
DIFFNHDI_00993	0.0	-	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
DIFFNHDI_00994	0.0	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
DIFFNHDI_00995	4.14e-229	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Zinc-uptake complex component A periplasmic
DIFFNHDI_00996	2.47e-101	-	-	-	-	-	-	-	-
DIFFNHDI_00997	2.15e-192	-	-	-	P	ko:K09820	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
DIFFNHDI_00998	6.95e-183	-	-	-	P	ko:K09819	-	ko00000,ko00002,ko02000	FecCD transport family
DIFFNHDI_00999	5.46e-126	-	-	-	S	ko:K19411	-	ko00000	UvrB/uvrC motif
DIFFNHDI_01000	2.26e-243	-	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	ATP:guanido phosphotransferase, C-terminal catalytic domain
DIFFNHDI_01001	0.0	-	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	C-terminal, D2-small domain, of ClpB protein
DIFFNHDI_01002	0.0	-	3.2.1.50	-	G	ko:K01205	ko00531,ko01100,ko04142,map00531,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha-L-fucosidase
DIFFNHDI_01003	1.93e-63	-	-	-	P	ko:K03972	-	ko00000	Rhodanese Homology Domain
DIFFNHDI_01004	2.1e-201	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
DIFFNHDI_01005	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	HMGL-like
DIFFNHDI_01006	1.28e-223	-	-	-	CO	-	-	-	amine dehydrogenase activity
DIFFNHDI_01007	8.39e-89	-	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
DIFFNHDI_01008	2.05e-163	-	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
DIFFNHDI_01009	7.55e-206	-	-	-	GM	-	-	-	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DIFFNHDI_01010	2.41e-232	-	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (W and Y)
DIFFNHDI_01011	1.56e-103	-	-	-	T	-	-	-	Universal stress protein family
DIFFNHDI_01012	1.45e-190	-	-	-	S	ko:K09769	-	ko00000	YmdB-like protein
DIFFNHDI_01013	4.13e-184	-	-	-	H	ko:K22132	-	ko00000,ko03016	ThiF family
DIFFNHDI_01014	9.9e-121	-	-	-	-	-	-	-	-
DIFFNHDI_01016	1.12e-229	-	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
DIFFNHDI_01017	3.22e-124	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
DIFFNHDI_01018	3.77e-289	kbl	2.3.1.29	-	E	ko:K00639	ko00260,map00260	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_01019	0.0	-	-	-	KLT	-	-	-	Sulfatase-modifying factor enzyme 1
DIFFNHDI_01020	1.06e-182	-	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	AAA domain
DIFFNHDI_01021	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
DIFFNHDI_01030	1.5e-30	-	-	-	M	-	-	-	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_01048	2.62e-21	-	-	-	OU	-	-	-	Serine dehydrogenase proteinase
DIFFNHDI_01053	4.01e-71	-	-	-	S	-	-	-	Phage terminase large subunit (GpA)
DIFFNHDI_01055	7.88e-98	-	-	-	D	-	-	-	Filamentation induced by cAMP protein fic
DIFFNHDI_01066	1.04e-54	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	thiamine diphosphate biosynthetic process
DIFFNHDI_01067	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DIFFNHDI_01068	0.0	-	-	-	M	ko:K02847,ko:K13009,ko:K16705	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	-O-antigen
DIFFNHDI_01069	8.67e-85	-	-	-	S	-	-	-	Protein of unknown function, DUF488
DIFFNHDI_01070	3.43e-234	-	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Porphobilinogen deaminase, dipyromethane cofactor binding domain
DIFFNHDI_01071	1.07e-240	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Glutamyl-tRNAGlu reductase, N-terminal domain
DIFFNHDI_01072	1.02e-178	-	-	-	S	-	-	-	Cytochrome C assembly protein
DIFFNHDI_01073	3.84e-189	folE2	3.5.4.16	-	S	ko:K09007	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Type I GTP cyclohydrolase folE2
DIFFNHDI_01074	8.46e-50	-	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S18
DIFFNHDI_01075	5.67e-33	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L33
DIFFNHDI_01076	1.46e-118	-	-	-	T	-	-	-	Prokaryotic dksA/traR C4-type zinc finger
DIFFNHDI_01077	5.9e-232	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
DIFFNHDI_01078	2.86e-245	sun	2.1.1.176, 2.1.1.178	-	J	ko:K03500,ko:K11392	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DIFFNHDI_01079	1.79e-122	-	-	-	S	ko:K07095	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
DIFFNHDI_01080	2.34e-97	nudI	3.6.1.55	-	F	ko:K03574,ko:K12944	-	ko00000,ko01000,ko03400	GDP-mannose mannosyl hydrolase activity
DIFFNHDI_01082	2.88e-283	-	-	-	M	ko:K02005	-	ko00000	HlyD family secretion protein
DIFFNHDI_01083	2.12e-162	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_01084	2.69e-310	-	-	-	V	-	-	-	MacB-like periplasmic core domain
DIFFNHDI_01085	8.19e-316	-	-	-	MU	-	-	-	Outer membrane efflux protein
DIFFNHDI_01086	1.57e-284	-	-	-	V	-	-	-	Beta-lactamase
DIFFNHDI_01087	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIFFNHDI_01088	6.02e-283	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIFFNHDI_01089	1.02e-94	-	-	-	K	-	-	-	DNA-binding transcription factor activity
DIFFNHDI_01090	2.51e-167	-	-	-	S	-	-	-	Uncharacterised protein family UPF0066
DIFFNHDI_01091	1.37e-306	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydro-orotase-like
DIFFNHDI_01092	1.55e-222	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
DIFFNHDI_01093	1.15e-122	-	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Phosphoribosyl transferase domain
DIFFNHDI_01094	3.73e-90	-	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR carboxylase
DIFFNHDI_01096	0.0	-	-	-	H	ko:K07137	-	ko00000	5-formyltetrahydrofolate cyclo-ligase activity
DIFFNHDI_01097	6.45e-268	-	3.5.3.12	-	E	ko:K10536	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Porphyromonas-type peptidyl-arginine deiminase
DIFFNHDI_01098	2.11e-89	-	-	-	-	-	-	-	-
DIFFNHDI_01099	0.0	rseP	3.4.21.116	-	M	ko:K06399,ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	metalloendopeptidase activity
DIFFNHDI_01100	1.7e-297	-	-	-	S	-	-	-	AI-2E family transporter
DIFFNHDI_01101	0.0	-	-	-	P	-	-	-	Domain of unknown function
DIFFNHDI_01103	2.25e-111	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
DIFFNHDI_01104	1.93e-313	-	-	-	G	-	-	-	cellulose 1,4-beta-cellobiosidase activity
DIFFNHDI_01105	4.02e-188	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
DIFFNHDI_01107	1.83e-74	-	-	-	-	-	-	-	-
DIFFNHDI_01108	0.0	-	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	DNA Topoisomerase IV
DIFFNHDI_01110	1.63e-135	-	-	-	S	-	-	-	Glycosyl hydrolase 108
DIFFNHDI_01113	1.24e-200	-	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	ParB-like nuclease domain
DIFFNHDI_01114	5.07e-235	-	-	-	S	-	-	-	Peptidase family M28
DIFFNHDI_01115	0.0	-	-	-	M	-	-	-	Aerotolerance regulator N-terminal
DIFFNHDI_01116	0.0	-	-	-	S	-	-	-	Large extracellular alpha-helical protein
DIFFNHDI_01119	1.11e-235	-	-	-	S	ko:K14347	-	ko00000,ko02000,ko04147	SBF-like CPA transporter family (DUF4137)
DIFFNHDI_01120	2.02e-278	-	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	tRNA synthetases class I (W and Y)
DIFFNHDI_01122	1.74e-85	-	-	-	S	ko:K09922	-	ko00000	Putative member of DMT superfamily (DUF486)
DIFFNHDI_01123	4.4e-211	-	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
DIFFNHDI_01124	1.6e-217	-	-	-	EP	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_01125	0.0	-	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
DIFFNHDI_01126	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
DIFFNHDI_01127	1.53e-219	-	-	-	O	-	-	-	Thioredoxin-like domain
DIFFNHDI_01128	4.57e-311	-	1.5.1.7	-	E	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Saccharopine dehydrogenase C-terminal domain
DIFFNHDI_01129	1.75e-235	-	-	-	S	ko:K01128	-	ko00000,ko01000	acid phosphatase activity
DIFFNHDI_01133	0.0	-	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Tubulin/FtsZ family, GTPase domain
DIFFNHDI_01134	3.38e-294	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
DIFFNHDI_01135	1.72e-147	-	-	-	M	-	-	-	NLP P60 protein
DIFFNHDI_01136	0.0	-	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
DIFFNHDI_01137	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
DIFFNHDI_01138	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
DIFFNHDI_01139	0.0	-	-	-	H	-	-	-	NAD synthase
DIFFNHDI_01140	7.86e-174	-	-	-	Q	ko:K02066	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Permease MlaE
DIFFNHDI_01141	4.3e-190	-	-	-	Q	ko:K02065	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_01142	1.33e-231	-	-	-	Q	ko:K02067	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MlaD protein
DIFFNHDI_01143	2.69e-38	-	-	-	T	-	-	-	ribosome binding
DIFFNHDI_01146	5.1e-265	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
DIFFNHDI_01147	9.11e-261	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
DIFFNHDI_01148	2.88e-249	ppiD	5.2.1.8	-	O	ko:K03769,ko:K03770,ko:K03771,ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl cis-trans isomerase activity
DIFFNHDI_01150	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01151	2.4e-180	kdsB	2.7.7.38	-	M	ko:K00979	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DIFFNHDI_01152	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
DIFFNHDI_01153	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
DIFFNHDI_01154	1.85e-30	-	-	-	-	-	-	-	-
DIFFNHDI_01155	0.0	-	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	C-terminal, D2-small domain, of ClpB protein
DIFFNHDI_01157	1.29e-230	-	-	-	K	-	-	-	DNA-binding transcription factor activity
DIFFNHDI_01159	1.05e-15	-	-	-	M	-	-	-	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DIFFNHDI_01160	2.16e-36	-	-	-	S	-	-	-	conserved domain
DIFFNHDI_01161	1.6e-92	-	-	-	L	-	-	-	IMG reference gene
DIFFNHDI_01162	7.36e-56	-	-	-	S	-	-	-	PFAM Cupin 2 conserved barrel domain protein
DIFFNHDI_01163	6.76e-131	-	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DIFFNHDI_01164	0.0	-	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DIFFNHDI_01165	0.0	-	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DIFFNHDI_01167	2.4e-167	-	-	-	T	ko:K07667	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
DIFFNHDI_01168	0.0	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
DIFFNHDI_01170	2.66e-06	-	-	-	-	-	-	-	-
DIFFNHDI_01171	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
DIFFNHDI_01172	1.78e-266	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2219)
DIFFNHDI_01173	4.37e-203	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
DIFFNHDI_01174	2.63e-84	-	-	-	M	-	-	-	Lysin motif
DIFFNHDI_01175	3.05e-180	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_01176	0.0	-	-	-	V	-	-	-	MatE
DIFFNHDI_01177	7.09e-251	-	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	adenosylhomocysteinase activity
DIFFNHDI_01179	1.02e-258	-	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
DIFFNHDI_01181	9.86e-158	-	-	-	M	-	-	-	Bacterial transferase hexapeptide (six repeats)
DIFFNHDI_01182	9.16e-266	-	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	RibD C-terminal domain
DIFFNHDI_01183	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
DIFFNHDI_01184	4.27e-273	-	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
DIFFNHDI_01185	0.0	-	-	-	O	-	-	-	Trypsin
DIFFNHDI_01186	1.18e-109	-	2.2.1.6	-	E	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	ACT domain
DIFFNHDI_01187	0.0	-	3.6.4.13	-	L	ko:K03578	-	ko00000,ko01000	Oligonucleotide/oligosaccharide-binding (OB)-fold
DIFFNHDI_01188	3.52e-161	-	-	-	P	ko:K03499	-	ko00000,ko02000	TrkA-N domain
DIFFNHDI_01189	0.0	-	-	-	P	-	-	-	Cation transport protein
DIFFNHDI_01191	3.14e-179	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
DIFFNHDI_01192	0.0	-	-	-	G	-	-	-	Domain of unknown function (DUF4091)
DIFFNHDI_01193	3.2e-70	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
DIFFNHDI_01194	1.32e-101	manC	-	-	S	-	-	-	Cupin domain
DIFFNHDI_01195	0.0	-	1.2.7.1	-	C	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DIFFNHDI_01197	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
DIFFNHDI_01198	1.02e-187	pppL	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	protein serine/threonine phosphatase activity
DIFFNHDI_01199	4.34e-152	-	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Glycerol-3-phosphate acyltransferase
DIFFNHDI_01200	8.08e-236	gpsA	1.1.1.94	-	C	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
DIFFNHDI_01201	8.62e-102	-	-	-	-	-	-	-	-
DIFFNHDI_01203	1.71e-264	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
DIFFNHDI_01204	1.32e-313	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
DIFFNHDI_01205	0.0	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
DIFFNHDI_01206	5.93e-05	-	-	-	-	-	-	-	-
DIFFNHDI_01207	0.0	-	-	-	O	ko:K07391	-	ko00000	Magnesium chelatase, subunit ChlI C-terminal
DIFFNHDI_01208	1.21e-210	-	-	-	S	-	-	-	Rhomboid family
DIFFNHDI_01209	2.63e-269	-	-	-	E	-	-	-	FAD dependent oxidoreductase
DIFFNHDI_01210	2.64e-267	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
DIFFNHDI_01213	0.0	-	-	-	S	-	-	-	Phosphoadenosine phosphosulfate reductase
DIFFNHDI_01214	3.45e-121	-	-	-	K	-	-	-	ParB domain protein nuclease
DIFFNHDI_01217	9.25e-106	-	-	-	L	-	-	-	Staphylococcal nuclease homologues
DIFFNHDI_01218	6.84e-248	-	-	-	M	-	-	-	Alginate lyase
DIFFNHDI_01219	3.1e-207	-	-	-	IQ	-	-	-	KR domain
DIFFNHDI_01222	7.17e-104	yciA	-	-	I	ko:K10806	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	acyl-coa hydrolase
DIFFNHDI_01223	9.75e-316	hsrA	-	-	EGP	-	-	-	Major facilitator Superfamily
DIFFNHDI_01224	1.41e-289	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_01225	5.6e-241	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
DIFFNHDI_01226	4.57e-181	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
DIFFNHDI_01227	0.0	-	3.2.1.23	-	G	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
DIFFNHDI_01228	8.77e-158	-	-	-	C	-	-	-	Nitroreductase family
DIFFNHDI_01229	0.0	-	-	-	E	-	-	-	Transglutaminase-like
DIFFNHDI_01230	5.58e-110	-	-	-	S	-	-	-	Bacterial transferase hexapeptide (six repeats)
DIFFNHDI_01231	6.56e-112	-	-	-	S	ko:K08999	-	ko00000	Bifunctional nuclease
DIFFNHDI_01233	0.0	-	-	-	P	-	-	-	Citrate transporter
DIFFNHDI_01235	2.8e-258	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
DIFFNHDI_01236	0.0	-	-	-	I	-	-	-	Acyltransferase family
DIFFNHDI_01237	2.57e-253	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
DIFFNHDI_01238	5.02e-310	-	-	-	M	-	-	-	Glycosyl transferases group 1
DIFFNHDI_01239	1.03e-204	-	-	-	-	-	-	-	-
DIFFNHDI_01240	2.74e-288	-	-	-	M	-	-	-	Glycosyltransferase like family 2
DIFFNHDI_01241	2.26e-245	-	5.1.3.20	-	M	ko:K03274	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	3-beta hydroxysteroid dehydrogenase/isomerase family
DIFFNHDI_01242	5.48e-235	-	-	GT9	M	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	ADP-heptose-lipopolysaccharide heptosyltransferase activity
DIFFNHDI_01243	6.79e-249	-	-	-	S	-	-	-	Glycosyltransferase like family 2
DIFFNHDI_01244	9.15e-244	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
DIFFNHDI_01245	1.03e-207	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
DIFFNHDI_01247	2.08e-241	-	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
DIFFNHDI_01248	9.36e-171	truB	5.4.99.25	-	J	ko:K03177	-	ko00000,ko01000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DIFFNHDI_01249	5.8e-219	-	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin kinase
DIFFNHDI_01250	9e-65	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DIFFNHDI_01251	3.86e-76	-	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase SecG subunit
DIFFNHDI_01252	3.3e-151	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
DIFFNHDI_01253	6.87e-256	-	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DIFFNHDI_01254	3.17e-129	-	-	-	-	-	-	-	-
DIFFNHDI_01255	1.02e-232	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
DIFFNHDI_01256	2.08e-62	-	-	-	S	-	-	-	OST-HTH/LOTUS domain
DIFFNHDI_01257	6.43e-153	ppaX_1	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
DIFFNHDI_01258	6.45e-138	-	-	-	S	-	-	-	Maltose acetyltransferase
DIFFNHDI_01259	0.0	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	GMP synthase C terminal domain
DIFFNHDI_01260	0.0	-	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	IMP dehydrogenase / GMP reductase domain
DIFFNHDI_01261	3.5e-121	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
DIFFNHDI_01262	0.0	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_01265	4.88e-265	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
DIFFNHDI_01266	1.89e-255	-	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
DIFFNHDI_01267	2.84e-286	-	-	-	S	-	-	-	Phosphotransferase enzyme family
DIFFNHDI_01268	3.23e-253	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DIFFNHDI_01270	7.86e-138	-	-	-	T	-	-	-	histone H2A K63-linked ubiquitination
DIFFNHDI_01271	1.56e-127	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIFFNHDI_01272	5.11e-222	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
DIFFNHDI_01273	3.48e-213	-	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIFFNHDI_01274	0.0	-	-	-	T	ko:K06207	-	ko00000	Elongation factor G C-terminus
DIFFNHDI_01275	7.64e-235	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
DIFFNHDI_01276	2.39e-314	-	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
DIFFNHDI_01277	6.62e-257	-	-	-	S	ko:K11744	-	ko00000	AI-2E family transporter
DIFFNHDI_01278	3.28e-155	gph	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
DIFFNHDI_01279	3.27e-294	-	-	-	E	-	-	-	Amino acid permease
DIFFNHDI_01280	4.07e-173	-	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Thiazole biosynthesis protein ThiG
DIFFNHDI_01282	1.79e-201	-	-	-	S	-	-	-	SigmaW regulon antibacterial
DIFFNHDI_01283	1.93e-242	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DIFFNHDI_01285	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
DIFFNHDI_01286	0.0	-	-	-	P	-	-	-	Dimerisation domain of Zinc Transporter
DIFFNHDI_01287	1.67e-172	-	-	-	K	-	-	-	Transcriptional regulator
DIFFNHDI_01288	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIFFNHDI_01289	6.66e-167	-	4.3.99.3	-	O	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
DIFFNHDI_01290	2.2e-173	-	2.7.13.3	-	Q	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Transposase
DIFFNHDI_01291	0.0	-	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
DIFFNHDI_01292	2.56e-312	-	-	-	S	-	-	-	Protein of unknown function (DUF1015)
DIFFNHDI_01293	7.38e-252	-	-	-	E	-	-	-	Aminotransferase class-V
DIFFNHDI_01294	5.45e-234	-	-	-	S	-	-	-	Conserved hypothetical protein 698
DIFFNHDI_01295	1.12e-214	-	-	-	K	-	-	-	LysR substrate binding domain
DIFFNHDI_01298	1.4e-287	-	3.2.1.23	-	M	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
DIFFNHDI_01299	6.01e-295	-	3.2.1.23	-	M	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
DIFFNHDI_01300	0.0	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
DIFFNHDI_01301	8.42e-302	-	4.2.1.129, 5.4.99.17, 5.5.1.16	-	I	ko:K06045,ko:K17811	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
DIFFNHDI_01302	9.82e-262	-	-	-	M	ko:K02022	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIFFNHDI_01303	1.1e-160	-	-	-	S	-	-	-	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DIFFNHDI_01305	5.12e-71	-	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Thioredoxin-like domain
DIFFNHDI_01306	5.48e-296	-	-	-	-	-	-	-	-
DIFFNHDI_01307	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
DIFFNHDI_01309	0.0	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
DIFFNHDI_01311	1.04e-109	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DIFFNHDI_01312	8.76e-126	-	-	-	-	-	-	-	-
DIFFNHDI_01313	0.0	-	-	-	U	ko:K03321	-	ko00000,ko02000	Sulfate permease family
DIFFNHDI_01314	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Argininosuccinate lyase C-terminal
DIFFNHDI_01315	1.45e-162	-	-	-	S	-	-	-	SWIM zinc finger
DIFFNHDI_01316	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01317	1.73e-307	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
DIFFNHDI_01318	1.47e-204	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DIFFNHDI_01319	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
DIFFNHDI_01320	3.29e-258	-	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
DIFFNHDI_01321	0.0	-	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein
DIFFNHDI_01322	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIFFNHDI_01323	3.31e-303	-	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	tRNA (Uracil-5-)-methyltransferase
DIFFNHDI_01326	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01327	7.36e-55	himA	-	-	L	ko:K03530,ko:K04764,ko:K05788	-	ko00000,ko03032,ko03036,ko03400	regulation of translation
DIFFNHDI_01328	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Glycosyl hydrolase family 36 N-terminal domain
DIFFNHDI_01329	0.0	-	-	-	P	ko:K07085	-	ko00000	Predicted Permease Membrane Region
DIFFNHDI_01330	2.68e-110	-	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
DIFFNHDI_01331	0.0	-	-	-	T	-	-	-	Histidine kinase
DIFFNHDI_01332	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
DIFFNHDI_01333	1.07e-188	-	1.97.1.4	-	O	ko:K04069	-	ko00000,ko01000	Radical SAM superfamily
DIFFNHDI_01334	3.8e-43	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	CTP reductase activity
DIFFNHDI_01335	0.0	-	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Anaerobic ribonucleoside-triphosphate reductase
DIFFNHDI_01336	0.0	-	-	-	M	-	-	-	Glycosyl Hydrolase Family 88
DIFFNHDI_01337	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF1705)
DIFFNHDI_01339	1.96e-121	ngr	-	-	C	-	-	-	Rubrerythrin
DIFFNHDI_01342	8.88e-268	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
DIFFNHDI_01343	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_01344	4.06e-287	-	-	-	EGP	-	-	-	Major facilitator Superfamily
DIFFNHDI_01345	2.05e-277	-	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Alkaline phosphatase homologues
DIFFNHDI_01346	3.06e-85	-	-	-	M	ko:K03282	-	ko00000,ko02000	Large-conductance mechanosensitive channel, MscL
DIFFNHDI_01347	1.95e-312	-	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
DIFFNHDI_01348	1.2e-105	-	-	-	S	-	-	-	ACT domain protein
DIFFNHDI_01349	9.29e-132	-	-	-	J	ko:K02356	-	ko00000,ko03012	Elongation factor P (EF-P) OB domain
DIFFNHDI_01350	1.16e-244	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
DIFFNHDI_01351	0.0	-	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
DIFFNHDI_01352	0.0	-	-	-	L	ko:K03631	-	ko00000,ko03400	RecF/RecN/SMC N terminal domain
DIFFNHDI_01353	3.05e-189	-	3.1.4.55	-	S	ko:K06167	ko00440,map00440	ko00000,ko00001,ko01000	Metallo-beta-lactamase superfamily
DIFFNHDI_01354	5.06e-192	-	-	-	M	-	-	-	Glycosyl transferase WecB/TagA/CpsF family
DIFFNHDI_01355	2.28e-170	yyaQ	-	-	V	-	-	-	Protein conserved in bacteria
DIFFNHDI_01356	4.67e-91	-	-	-	-	-	-	-	-
DIFFNHDI_01359	4.72e-206	-	-	-	S	ko:K09949	-	ko00000	Protein of unknown function (DUF1009)
DIFFNHDI_01360	1.63e-298	-	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
DIFFNHDI_01361	9.47e-236	-	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
DIFFNHDI_01362	1.13e-221	-	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
DIFFNHDI_01363	2.52e-197	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DIFFNHDI_01364	1e-242	-	-	-	M	ko:K18094	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	Biotin-lipoyl like
DIFFNHDI_01365	0.0	-	-	-	V	ko:K18095	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	AcrB/AcrD/AcrF family
DIFFNHDI_01366	0.0	-	-	-	S	-	-	-	pathogenesis
DIFFNHDI_01367	2.1e-99	-	-	-	S	-	-	-	peptidase
DIFFNHDI_01368	5.18e-172	-	-	-	S	ko:K06973	-	ko00000	Putative neutral zinc metallopeptidase
DIFFNHDI_01369	2.24e-101	-	-	-	S	-	-	-	peptidase
DIFFNHDI_01370	0.0	-	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase HemD
DIFFNHDI_01371	4.53e-100	-	-	-	-	-	-	-	-
DIFFNHDI_01372	0.0	-	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Bacterial DNA topoisomeraes I ATP-binding domain
DIFFNHDI_01376	8.8e-169	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
DIFFNHDI_01377	0.0	-	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
DIFFNHDI_01378	2.57e-133	-	-	-	D	-	-	-	ErfK ybiS ycfS ynhG family protein
DIFFNHDI_01380	2.51e-284	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIFFNHDI_01382	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
DIFFNHDI_01383	3.36e-271	-	-	-	S	-	-	-	tRNA-splicing ligase RtcB
DIFFNHDI_01384	4.55e-213	-	-	-	K	-	-	-	LysR substrate binding domain
DIFFNHDI_01385	3.53e-295	-	-	-	EGP	-	-	-	Major facilitator Superfamily
DIFFNHDI_01387	7.1e-130	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
DIFFNHDI_01388	6.52e-75	-	-	-	L	-	-	-	Cupin 2, conserved barrel domain protein
DIFFNHDI_01389	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
DIFFNHDI_01391	0.0	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Collagenase
DIFFNHDI_01392	1.53e-286	-	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Mur ligase middle domain
DIFFNHDI_01394	0.0	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
DIFFNHDI_01395	0.0	-	2.7.11.1	-	L	ko:K08282	-	ko00000,ko01000	SNF2 Helicase protein
DIFFNHDI_01396	0.0	-	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Calcineurin-like phosphoesterase
DIFFNHDI_01397	1.77e-124	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
DIFFNHDI_01398	4.9e-207	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DIFFNHDI_01399	1.53e-47	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S L24/mitochondrial 39S L24
DIFFNHDI_01400	5.36e-138	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DIFFNHDI_01401	4.08e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DIFFNHDI_01402	2.25e-105	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DIFFNHDI_01403	2.38e-74	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DIFFNHDI_01404	3.38e-102	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DIFFNHDI_01405	6.42e-101	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
DIFFNHDI_01407	0.0	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
DIFFNHDI_01408	6.41e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
DIFFNHDI_01409	1.29e-192	map	3.4.11.18	-	J	ko:K01265	-	ko00000,ko01000,ko01002	Metallopeptidase family M24
DIFFNHDI_01410	8.13e-264	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_01411	0.0	-	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	Ppx/GppA phosphatase family
DIFFNHDI_01412	0.0	-	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Polyphosphate kinase middle domain
DIFFNHDI_01413	1.24e-282	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
DIFFNHDI_01415	8.96e-274	-	-	GT2	S	ko:K19427	-	ko00000,ko01000	PFAM glycosyl transferase family 2
DIFFNHDI_01416	3.06e-226	-	-	-	S	-	-	-	Glycosyl transferase family 11
DIFFNHDI_01417	4.88e-263	-	-	-	S	-	-	-	Glycosyltransferase like family 2
DIFFNHDI_01418	3.37e-292	-	-	-	-	-	-	-	-
DIFFNHDI_01419	6.2e-265	-	-	-	S	-	-	-	PFAM glycosyl transferase family 2
DIFFNHDI_01420	3.93e-128	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
DIFFNHDI_01421	1.38e-230	-	-	-	C	-	-	-	e3 binding domain
DIFFNHDI_01422	4.34e-284	-	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DIFFNHDI_01423	4.05e-135	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIFFNHDI_01424	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
DIFFNHDI_01425	0.0	-	-	-	T	-	-	-	5TM C-terminal transporter carbon starvation CstA
DIFFNHDI_01426	9.44e-159	-	-	-	-	-	-	-	-
DIFFNHDI_01427	0.0	-	-	-	P	-	-	-	PA14 domain
DIFFNHDI_01428	3.87e-80	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DIFFNHDI_01429	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DIFFNHDI_01430	5.58e-289	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	NusA-like KH domain
DIFFNHDI_01431	3.73e-195	-	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease/Exonuclease/phosphatase family
DIFFNHDI_01432	1.72e-144	-	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DIFFNHDI_01433	2.47e-134	-	-	-	J	-	-	-	Putative rRNA methylase
DIFFNHDI_01434	2.83e-204	-	-	-	S	-	-	-	Domain of unknown function (DUF362)
DIFFNHDI_01435	0.0	-	-	-	C	-	-	-	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein
DIFFNHDI_01436	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
DIFFNHDI_01438	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01439	1.02e-184	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_01440	7.33e-143	-	-	-	S	-	-	-	RNA recognition motif
DIFFNHDI_01441	0.0	-	-	-	M	-	-	-	Bacterial sugar transferase
DIFFNHDI_01442	8.88e-284	-	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Galactokinase galactose-binding signature
DIFFNHDI_01443	0.0	-	-	-	S	ko:K03307	-	ko00000	Sodium:solute symporter family
DIFFNHDI_01445	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
DIFFNHDI_01446	3.02e-227	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DIFFNHDI_01447	6.81e-273	-	-	-	M	-	-	-	Monogalactosyldiacylglycerol (MGDG) synthase
DIFFNHDI_01448	7.16e-174	coaX	2.7.1.33	-	K	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Type III pantothenate kinase
DIFFNHDI_01449	8.56e-45	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Phosphopantetheine attachment site
DIFFNHDI_01450	3.5e-132	-	-	-	-	-	-	-	-
DIFFNHDI_01451	5.19e-178	-	-	-	S	-	-	-	Lysin motif
DIFFNHDI_01452	1.07e-98	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
DIFFNHDI_01453	2.93e-39	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_01455	7.66e-106	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_01456	1.38e-205	-	-	-	M	-	-	-	self proteolysis
DIFFNHDI_01459	1.19e-21	-	-	-	M	-	-	-	self proteolysis
DIFFNHDI_01464	0.0	-	-	-	M	-	-	-	pathogenesis
DIFFNHDI_01466	1.3e-265	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
DIFFNHDI_01472	4.6e-149	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_01475	2.94e-31	-	-	-	K	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_01476	1.11e-60	-	-	-	S	-	-	-	Nucleotidyl transferase AbiEii toxin, Type IV TA system
DIFFNHDI_01477	4.74e-07	-	-	-	KLT	-	-	-	Lanthionine synthetase C-like protein
DIFFNHDI_01478	8.51e-46	-	-	-	S	-	-	-	von Willebrand factor type A domain
DIFFNHDI_01479	2.23e-127	-	-	-	S	-	-	-	Virulence protein RhuM family
DIFFNHDI_01480	2.7e-60	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
DIFFNHDI_01484	9.42e-07	-	-	-	S	-	-	-	TM2 domain
DIFFNHDI_01487	4.43e-39	-	-	-	-	-	-	-	-
DIFFNHDI_01488	5.53e-96	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
DIFFNHDI_01489	1.23e-206	-	2.1.1.72	-	L	ko:K03427	-	ko00000,ko01000,ko02048	Putative RNA methylase family UPF0020
DIFFNHDI_01490	2.43e-101	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
DIFFNHDI_01491	2.59e-301	-	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	COG COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
DIFFNHDI_01492	3.62e-108	-	-	-	S	-	-	-	Meiotically up-regulated gene 113
DIFFNHDI_01493	1.19e-47	-	-	-	S	-	-	-	Domain of unknown function (DUF932)
DIFFNHDI_01500	0.0	-	-	-	P	-	-	-	Cation transport protein
DIFFNHDI_01501	2.48e-300	-	-	-	V	ko:K03327	-	ko00000,ko02000	drug transmembrane transporter activity
DIFFNHDI_01502	1.83e-120	-	-	-	-	-	-	-	-
DIFFNHDI_01503	9.86e-54	-	-	-	-	-	-	-	-
DIFFNHDI_01504	7.2e-103	-	-	-	-	-	-	-	-
DIFFNHDI_01505	0.0	-	2.1.1.182	-	IJ	ko:K02528	-	ko00000,ko01000,ko03009	Ribosomal RNA adenine dimethylases
DIFFNHDI_01506	1.26e-247	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
DIFFNHDI_01507	0.0	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
DIFFNHDI_01508	6.39e-119	-	-	-	T	-	-	-	STAS domain
DIFFNHDI_01509	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF2851)
DIFFNHDI_01510	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
DIFFNHDI_01511	3.09e-290	-	-	-	-	-	-	-	-
DIFFNHDI_01512	0.0	-	-	-	M	-	-	-	Sulfatase
DIFFNHDI_01513	6.68e-286	-	4.1.99.19	-	H	ko:K03150	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Biotin and Thiamin Synthesis associated domain
DIFFNHDI_01514	6.59e-205	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
DIFFNHDI_01515	4.71e-267	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
DIFFNHDI_01516	0.0	-	-	-	T	-	-	-	pathogenesis
DIFFNHDI_01517	0.0	-	4.2.1.9	-	EG	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Dehydratase family
DIFFNHDI_01518	6.89e-168	-	-	-	T	ko:K07657	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
DIFFNHDI_01519	5.8e-289	-	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
DIFFNHDI_01520	2.09e-10	-	-	-	S	-	-	-	Mitochondrial domain of unknown function (DUF1713)
DIFFNHDI_01521	1.11e-206	hisG	2.4.2.17	-	E	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	ATP phosphoribosyltransferase
DIFFNHDI_01522	2.04e-314	-	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Aminopeptidase P, N-terminal domain
DIFFNHDI_01523	5.68e-155	-	-	-	S	-	-	-	Protein of unknown function (DUF3313)
DIFFNHDI_01524	2.93e-260	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DIFFNHDI_01525	9.39e-256	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
DIFFNHDI_01526	2.8e-169	-	-	-	-	-	-	-	-
DIFFNHDI_01527	0.0	-	-	-	NU	-	-	-	Type IV pilus assembly protein PilM;
DIFFNHDI_01528	6.11e-208	-	-	-	-	-	-	-	-
DIFFNHDI_01529	2.27e-245	-	-	-	-	-	-	-	-
DIFFNHDI_01530	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
DIFFNHDI_01531	1.85e-142	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIFFNHDI_01532	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIFFNHDI_01533	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
DIFFNHDI_01534	1.65e-240	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
DIFFNHDI_01535	1.1e-131	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
DIFFNHDI_01536	5.44e-229	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DIFFNHDI_01537	0.0	-	1.11.1.5	-	P	ko:K00428	-	ko00000,ko01000	Di-haem cytochrome c peroxidase
DIFFNHDI_01538	2.48e-40	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
DIFFNHDI_01539	4.02e-48	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
DIFFNHDI_01540	0.0	-	-	-	P	ko:K04759	-	ko00000,ko02000	Ferrous iron transport protein B C terminus
DIFFNHDI_01543	2.83e-303	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
DIFFNHDI_01545	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
DIFFNHDI_01546	4.92e-90	-	-	-	K	-	-	-	Helix-turn-helix diphteria tox regulatory element
DIFFNHDI_01547	4.56e-206	-	3.1.1.53	-	L	ko:K03547,ko:K05970	-	ko00000,ko01000,ko03400	3'-5' exonuclease activity
DIFFNHDI_01548	2.86e-133	-	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	SpoU rRNA Methylase family
DIFFNHDI_01549	0.0	-	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
DIFFNHDI_01550	9.76e-258	-	-	-	S	-	-	-	Glycoside-hydrolase family GH114
DIFFNHDI_01551	8.72e-301	-	-	-	M	-	-	-	Glycosyl transferases group 1
DIFFNHDI_01553	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RecQ zinc-binding
DIFFNHDI_01554	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
DIFFNHDI_01555	8.66e-227	-	-	-	-	-	-	-	-
DIFFNHDI_01556	1.97e-316	-	-	-	H	-	-	-	Flavin containing amine oxidoreductase
DIFFNHDI_01557	8.88e-247	-	-	-	-	-	-	-	-
DIFFNHDI_01558	3.5e-249	rgpB	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
DIFFNHDI_01559	0.0	ahcY	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DIFFNHDI_01560	3.77e-291	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DIFFNHDI_01561	3.9e-214	-	-	-	KQ	-	-	-	Hypothetical methyltransferase
DIFFNHDI_01564	0.0	-	-	-	E	-	-	-	PFAM major facilitator superfamily MFS_1
DIFFNHDI_01565	3.17e-206	-	-	-	G	ko:K06867,ko:K07001	-	ko00000	response to abiotic stimulus
DIFFNHDI_01567	1.01e-293	-	-	-	MU	ko:K15725	-	ko00000,ko02000	efflux transmembrane transporter activity
DIFFNHDI_01568	1.96e-297	czcB	-	-	M	ko:K15727	-	ko00000,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIFFNHDI_01569	0.0	-	-	-	P	ko:K07239	-	ko00000	AcrB/AcrD/AcrF family
DIFFNHDI_01570	3.44e-146	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
DIFFNHDI_01572	2.38e-169	-	-	-	CO	-	-	-	Protein conserved in bacteria
DIFFNHDI_01573	2.6e-231	-	1.5.1.20	-	E	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
DIFFNHDI_01574	4.84e-155	-	1.14.11.27	-	P	ko:K10277	-	ko00000,ko01000,ko03036	peptidyl-arginine hydroxylation
DIFFNHDI_01575	0.0	-	-	-	M	ko:K07277	-	ko00000,ko02000,ko03029	Surface antigen
DIFFNHDI_01576	8.38e-282	tig	-	-	O	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
DIFFNHDI_01577	2.5e-153	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
DIFFNHDI_01578	0.0	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DIFFNHDI_01579	3.39e-254	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DIFFNHDI_01581	9.94e-287	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DIFFNHDI_01583	3.61e-46	-	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SecE/Sec61-gamma subunits of protein translocation complex
DIFFNHDI_01584	6.29e-135	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.
DIFFNHDI_01585	2.58e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DIFFNHDI_01586	1.74e-156	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
DIFFNHDI_01587	9.92e-110	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DIFFNHDI_01588	3.69e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
DIFFNHDI_01590	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DIFFNHDI_01592	1.02e-203	dapA	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
DIFFNHDI_01593	4.14e-175	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate reductase, N-terminus
DIFFNHDI_01594	4.21e-121	-	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
DIFFNHDI_01595	4.13e-183	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
DIFFNHDI_01596	5.03e-229	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
DIFFNHDI_01597	7.29e-211	-	-	-	M	-	-	-	Peptidase family M23
DIFFNHDI_01607	3.2e-21	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_01610	4.19e-82	recT	-	-	L	ko:K07455	-	ko00000,ko03400	COG3723 Recombinational DNA repair protein (RecE pathway)
DIFFNHDI_01611	4.32e-06	Z012_11975	-	-	M	-	-	-	protein involved in exopolysaccharide biosynthesis
DIFFNHDI_01612	4.52e-18	-	-	-	L	-	-	-	YqaJ-like viral recombinase domain
DIFFNHDI_01620	8.39e-34	-	-	-	EH	-	-	-	sulfate reduction
DIFFNHDI_01621	4.47e-63	-	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	PFAM D12 class N6 adenine-specific DNA methyltransferase
DIFFNHDI_01624	1.59e-43	-	-	-	KL	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_01625	8.93e-141	-	-	-	K	ko:K12055	-	ko00000,ko02044	chromosome segregation
DIFFNHDI_01629	2.06e-240	-	-	-	S	-	-	-	Phage terminase large subunit (GpA)
DIFFNHDI_01631	1.12e-159	-	-	-	S	-	-	-	Phage portal protein, lambda family
DIFFNHDI_01632	3.83e-96	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Clp protease
DIFFNHDI_01633	2.69e-84	-	-	-	S	-	-	-	Phage major capsid protein E
DIFFNHDI_01635	1.05e-16	-	-	-	-	-	-	-	-
DIFFNHDI_01637	4.11e-203	-	-	-	S	ko:K06907	-	ko00000	COG3497 Phage tail sheath protein FI
DIFFNHDI_01641	8.61e-60	-	-	-	M	-	-	-	tail tape measure protein
DIFFNHDI_01642	4.95e-18	-	-	-	S	-	-	-	Phage Tail Protein X
DIFFNHDI_01643	5.85e-62	-	-	-	S	ko:K06905	-	ko00000	COG3500 Phage protein D
DIFFNHDI_01646	1.08e-12	-	-	-	-	-	-	-	-
DIFFNHDI_01647	1.36e-67	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.87
DIFFNHDI_01648	5.77e-40	-	-	-	S	-	-	-	Phage tail protein (Tail_P2_I)
DIFFNHDI_01649	1.5e-07	-	-	-	D	-	-	-	nuclear chromosome segregation
DIFFNHDI_01653	8.59e-127	-	-	-	S	-	-	-	Glycosyl hydrolase 108
DIFFNHDI_01654	2.78e-22	-	-	-	S	-	-	-	phage Tail Collar
DIFFNHDI_01657	1.23e-110	-	-	-	S	-	-	-	Acetyltransferase (GNAT) family
DIFFNHDI_01658	1.26e-136	-	-	-	C	-	-	-	Nitroreductase family
DIFFNHDI_01660	0.0	-	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
DIFFNHDI_01661	1.66e-87	-	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
DIFFNHDI_01662	8.8e-239	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DIFFNHDI_01663	8.07e-174	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	tRNA (Guanine-1)-methyltransferase
DIFFNHDI_01664	2.05e-28	-	-	-	-	-	-	-	-
DIFFNHDI_01665	1.21e-238	-	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
DIFFNHDI_01666	3.94e-243	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
DIFFNHDI_01667	8.48e-56	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
DIFFNHDI_01668	0.0	-	-	-	J	ko:K07576	-	ko00000	Beta-Casp domain
DIFFNHDI_01669	1.55e-83	-	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	ArsC family
DIFFNHDI_01670	8.34e-180	-	-	-	P	ko:K10716	-	ko00000,ko02000	domain protein
DIFFNHDI_01671	0.0	-	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Carbohydrate phosphorylase
DIFFNHDI_01672	1.68e-257	tdh	1.1.1.103	-	E	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
DIFFNHDI_01673	2.31e-162	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
DIFFNHDI_01675	1.62e-184	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
DIFFNHDI_01676	3.92e-115	-	-	-	-	-	-	-	-
DIFFNHDI_01680	0.0	-	-	-	L	-	-	-	DNA restriction-modification system
DIFFNHDI_01683	7.23e-164	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
DIFFNHDI_01685	1.23e-177	-	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
DIFFNHDI_01687	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
DIFFNHDI_01688	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIFFNHDI_01689	2.76e-267	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIFFNHDI_01690	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
DIFFNHDI_01692	0.0	-	-	-	G	-	-	-	alpha-galactosidase
DIFFNHDI_01695	0.0	poxB	1.2.3.3, 1.2.5.1	-	EH	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Thiamine pyrophosphate enzyme, central domain
DIFFNHDI_01696	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DIFFNHDI_01697	9.11e-182	-	-	-	L	ko:K10800	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	uracil-dna glycosylase
DIFFNHDI_01698	1.13e-228	-	2.7.1.11	-	G	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Phosphofructokinase
DIFFNHDI_01699	7.56e-271	-	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Male sterility protein
DIFFNHDI_01700	9.14e-204	-	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DIFFNHDI_01702	0.0	-	-	-	C	-	-	-	Acetyl-CoA hydrolase/transferase C-terminal domain
DIFFNHDI_01703	9.48e-192	-	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Biotin/lipoate A/B protein ligase family
DIFFNHDI_01704	0.0	-	4.1.1.3	-	C	ko:K01572	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Na+-transporting oxaloacetate decarboxylase beta subunit
DIFFNHDI_01705	1.39e-54	-	-	-	I	-	-	-	PFAM biotin lipoyl attachment domain-containing protein
DIFFNHDI_01707	0.0	-	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Carboxyl transferase domain
DIFFNHDI_01708	4.12e-100	-	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Glyoxalase-like domain
DIFFNHDI_01709	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_01710	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
DIFFNHDI_01712	0.000232	-	2.7.11.1, 2.7.11.17	-	T	ko:K08794,ko:K13412,ko:K17530	ko04626,ko04921,ko04925,ko05145,map04626,map04921,map04925,map05145	ko00000,ko00001,ko01000,ko01001	protein serine/threonine kinase activity
DIFFNHDI_01713	0.0	-	-	-	S	-	-	-	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DIFFNHDI_01714	1.34e-298	-	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DIFFNHDI_01715	3.13e-114	-	-	-	P	-	-	-	Rhodanese-like domain
DIFFNHDI_01716	1.19e-152	-	-	-	S	-	-	-	Protein of unknown function (DUF1573)
DIFFNHDI_01717	1.76e-186	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase (SPase) II
DIFFNHDI_01718	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIFFNHDI_01719	1e-248	-	-	-	I	-	-	-	alpha/beta hydrolase fold
DIFFNHDI_01720	9.38e-260	-	-	-	S	-	-	-	Peptidase family M28
DIFFNHDI_01721	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
DIFFNHDI_01722	5.62e-57	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
DIFFNHDI_01723	2.27e-90	-	-	-	S	ko:K09793	-	ko00000	Protein of unknown function (DUF456)
DIFFNHDI_01724	2.45e-205	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
DIFFNHDI_01725	0.0	-	-	-	M	ko:K09808	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MacB-like periplasmic core domain
DIFFNHDI_01726	3.74e-208	-	-	-	S	-	-	-	RDD family
DIFFNHDI_01727	1.25e-132	-	2.3.1.129	-	M	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	ko00000,ko00001,ko00002,ko01000,ko01005	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIFFNHDI_01728	1.4e-171	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
DIFFNHDI_01729	5.99e-286	-	-	-	S	ko:K09760	-	ko00000	RmuC family
DIFFNHDI_01730	0.0	-	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Transglycosylase
DIFFNHDI_01731	1.35e-240	-	-	-	O	-	-	-	Trypsin-like peptidase domain
DIFFNHDI_01732	5.88e-277	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
DIFFNHDI_01734	3.53e-255	-	-	-	S	-	-	-	Putative S-adenosyl-L-methionine-dependent methyltransferase
DIFFNHDI_01735	1.38e-226	-	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate synthetase A protein
DIFFNHDI_01736	1.26e-301	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DIFFNHDI_01737	0.0	-	3.2.1.52	GH20	G	ko:K01207,ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko01501,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map01501,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_01739	5.32e-108	-	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	6-pyruvoyl tetrahydropterin synthase
DIFFNHDI_01741	0.0	-	4.2.1.2	-	C	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible hydration of fumarate to (S)- malate
DIFFNHDI_01742	2.57e-251	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_01743	0.0	secD	-	-	U	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIFFNHDI_01747	5.93e-261	-	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_01748	8.43e-155	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
DIFFNHDI_01749	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycosyl hydrolase family 20, domain 2
DIFFNHDI_01750	1.76e-179	-	-	-	M	-	-	-	NLP P60 protein
DIFFNHDI_01751	6.77e-87	-	-	-	S	ko:K09940	-	ko00000	Domain of unknown function (DUF4870)
DIFFNHDI_01753	4.94e-75	-	-	-	C	ko:K04651	-	ko00000,ko03110	Hydrogenase/urease nickel incorporation, metallochaperone, hypA
DIFFNHDI_01754	3.4e-126	-	-	-	C	ko:K03605	-	ko00000,ko01000,ko01002	Hydrogenase maturation protease
DIFFNHDI_01755	6.49e-290	hyaC	-	-	C	ko:K03620	ko02020,map02020	ko00000,ko00001	Prokaryotic cytochrome b561
DIFFNHDI_01756	0.0	-	1.12.99.6	-	C	ko:K06281	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nickel-dependent hydrogenase
DIFFNHDI_01757	6.94e-298	-	1.12.99.6	-	C	ko:K06282	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	NiFe/NiFeSe hydrogenase small subunit C-terminal
DIFFNHDI_01758	0.0	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
DIFFNHDI_01760	9.83e-317	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DIFFNHDI_01761	0.0	-	-	-	H	-	-	-	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DIFFNHDI_01762	0.0	-	3.4.24.3	-	NU	ko:K01387	-	ko00000,ko01000,ko01002,ko02042	translation initiation factor activity
DIFFNHDI_01763	0.0	-	-	-	M	-	-	-	Transglycosylase
DIFFNHDI_01764	2.63e-135	-	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	Peptidyl-tRNA hydrolase
DIFFNHDI_01765	4.58e-215	-	-	-	S	-	-	-	Protein of unknown function DUF58
DIFFNHDI_01766	3.82e-231	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
DIFFNHDI_01767	2.46e-216	-	3.5.1.53	-	K	ko:K12251	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
DIFFNHDI_01769	2.36e-273	-	-	-	E	-	-	-	Alcohol dehydrogenase GroES-like domain
DIFFNHDI_01770	2.56e-309	-	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Seryl-tRNA synthetase N-terminal domain
DIFFNHDI_01772	1.47e-19	-	-	-	H	-	-	-	Elongator protein 3, MiaB family, Radical SAM
DIFFNHDI_01777	1.08e-266	-	-	-	H	-	-	-	Elongator protein 3, MiaB family, Radical SAM
DIFFNHDI_01778	0.0	yidC	-	-	O	ko:K03217,ko:K06872	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	serine-type endopeptidase activity
DIFFNHDI_01779	3.06e-157	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_01780	2.76e-129	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DIFFNHDI_01781	1.02e-256	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Glycosyl hydrolase family 3 N terminal domain
DIFFNHDI_01782	4.86e-230	exsH	3.2.1.178, 3.2.1.18, 3.2.1.52	GH16,GH20,GH33	G	ko:K01186,ko:K12373,ko:K20830	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	xyloglucan:xyloglucosyl transferase activity
DIFFNHDI_01783	0.0	-	-	-	I	ko:K06889,ko:K09914	-	ko00000	PFAM Prenyltransferase squalene oxidase
DIFFNHDI_01784	4.24e-314	-	1.1.1.40	-	C	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Malic enzyme, NAD binding domain
DIFFNHDI_01787	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DIFFNHDI_01788	0.0	-	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
DIFFNHDI_01789	2.14e-300	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
DIFFNHDI_01790	1.19e-92	-	5.1.3.29	-	G	ko:K02431	-	ko00000,ko01000	RbsD / FucU transport protein family
DIFFNHDI_01791	6.17e-284	-	-	-	S	-	-	-	very-long-chain-acyl-CoA dehydrogenase activity
DIFFNHDI_01793	0.0	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_01794	3.82e-231	-	-	-	C	-	-	-	Nitroreductase family
DIFFNHDI_01795	0.0	-	-	-	S	-	-	-	polysaccharide biosynthetic process
DIFFNHDI_01796	3.13e-123	-	-	-	C	-	-	-	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_01797	1.55e-39	-	-	-	M	-	-	-	Glycosyltransferase, group 2 family protein
DIFFNHDI_01798	6.17e-237	-	-	-	M	-	-	-	Glycosyl transferase, family 2
DIFFNHDI_01799	3.34e-208	-	-	-	M	-	-	-	PFAM glycosyl transferase family 2
DIFFNHDI_01800	2.67e-113	-	-	-	S	ko:K03818	-	ko00000,ko01000	maltose O-acetyltransferase activity
DIFFNHDI_01801	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01802	3.29e-279	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
DIFFNHDI_01803	5.24e-279	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
DIFFNHDI_01804	1.32e-249	-	-	-	M	-	-	-	Glycosyl transferases group 1
DIFFNHDI_01805	2.42e-198	-	-	-	S	-	-	-	Glycosyl transferase family 11
DIFFNHDI_01806	9.16e-264	-	-	-	M	ko:K02847,ko:K13009	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	-O-antigen
DIFFNHDI_01807	1.71e-241	-	-	-	-	-	-	-	-
DIFFNHDI_01808	9.22e-290	gtf1	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
DIFFNHDI_01809	8.15e-285	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
DIFFNHDI_01810	3.33e-289	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
DIFFNHDI_01811	1.77e-191	wbyL	-	GT2	M	ko:K13002	-	ko00000,ko01000,ko01003,ko01005	transferase activity, transferring glycosyl groups
DIFFNHDI_01812	6.88e-176	-	-	-	M	-	-	-	Bacterial sugar transferase
DIFFNHDI_01813	9.48e-165	-	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	protein tyrosine phosphatase activity
DIFFNHDI_01814	0.0	gumC	-	-	DM	ko:K16554	ko05111,map05111	ko00000,ko00001,ko02000	PFAM lipopolysaccharide biosynthesis protein
DIFFNHDI_01815	5.68e-180	-	-	-	M	ko:K01991	ko02026,map02026	ko00000,ko00001,ko02000	polysaccharide export
DIFFNHDI_01816	0.0	-	-	-	D	ko:K03466	-	ko00000,ko03036	Ftsk_gamma
DIFFNHDI_01818	7.6e-145	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIFFNHDI_01819	1.08e-136	rbr	-	-	C	-	-	-	Rubrerythrin
DIFFNHDI_01820	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
DIFFNHDI_01822	0.0	-	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	Catalase
DIFFNHDI_01823	1.01e-45	-	-	-	S	-	-	-	R3H domain
DIFFNHDI_01825	0.0	-	1.2.1.88, 1.5.5.2	-	CE	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko03000	Proline dehydrogenase
DIFFNHDI_01826	7.62e-284	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
DIFFNHDI_01827	2.92e-123	-	-	-	L	ko:K19118	-	ko00000,ko02048	CRISPR-associated protein Cas7
DIFFNHDI_01828	5.48e-134	csd1	3.5.1.28	-	M	ko:K01447,ko:K17733,ko:K19117	-	ko00000,ko01000,ko01002,ko01011,ko02048	N-Acetylmuramoyl-L-alanine amidase
DIFFNHDI_01829	1.71e-111	cas5d	-	-	S	ko:K19119	-	ko00000,ko02048	TIGRFAM CRISPR-associated protein Cas5
DIFFNHDI_01830	3.53e-133	-	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	DEAD-like helicases superfamily
DIFFNHDI_01831	2.22e-65	-	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	Domain of unknown function DUF83
DIFFNHDI_01832	2.12e-141	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DIFFNHDI_01833	2.15e-34	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DIFFNHDI_01836	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
DIFFNHDI_01838	0.0	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
DIFFNHDI_01839	2.52e-281	-	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
DIFFNHDI_01840	1.12e-116	agmK	1.8.1.8	-	O	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko03110	belongs to the thioredoxin family
DIFFNHDI_01841	2.72e-181	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
DIFFNHDI_01843	0.0	-	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
DIFFNHDI_01844	2.18e-218	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DIFFNHDI_01845	5.88e-259	-	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	endonuclease III
DIFFNHDI_01846	4.25e-144	aat	2.3.2.6	-	O	ko:K00684	-	ko00000,ko01000	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DIFFNHDI_01847	0.0	-	2.7.9.1	-	G	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Pyruvate phosphate dikinase, PEP/pyruvate binding domain
DIFFNHDI_01848	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglucose isomerase
DIFFNHDI_01849	3.86e-261	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
DIFFNHDI_01850	4.45e-225	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
DIFFNHDI_01852	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
DIFFNHDI_01853	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
DIFFNHDI_01854	0.0	-	-	-	D	-	-	-	nuclear chromosome segregation
DIFFNHDI_01855	2.94e-131	-	-	-	-	-	-	-	-
DIFFNHDI_01856	2.75e-244	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
DIFFNHDI_01859	8.93e-181	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyrroline-5-carboxylate reductase dimerisation
DIFFNHDI_01860	4.69e-159	-	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
DIFFNHDI_01861	5.51e-211	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIFFNHDI_01862	6.59e-227	-	-	-	S	-	-	-	Protein conserved in bacteria
DIFFNHDI_01863	2.01e-34	-	-	-	KLT	-	-	-	Tyrosine-protein kinase, subgroup, catalytic domain
DIFFNHDI_01864	0.0	-	4.1.99.1	-	E	ko:K01667	ko00380,map00380	ko00000,ko00001,ko01000	Beta-eliminating lyase
DIFFNHDI_01865	6.76e-143	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
DIFFNHDI_01866	1.75e-255	-	-	-	S	-	-	-	Domain of unknown function (DUF4105)
DIFFNHDI_01867	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	B3/4 domain
DIFFNHDI_01868	6.99e-242	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Aminoacyl tRNA synthetase class II, N-terminal domain
DIFFNHDI_01869	1.11e-283	-	-	-	P	ko:K03449	-	ko00000,ko02000	Major Facilitator Superfamily
DIFFNHDI_01870	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
DIFFNHDI_01871	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Hsp90 protein
DIFFNHDI_01872	6.67e-172	-	-	-	P	ko:K10716	-	ko00000,ko02000	domain protein
DIFFNHDI_01873	1.95e-273	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIFFNHDI_01874	9.25e-103	-	-	-	K	-	-	-	Transcriptional regulator
DIFFNHDI_01875	8.64e-312	-	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
DIFFNHDI_01876	9.2e-215	-	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
DIFFNHDI_01877	8.4e-136	thiE	2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17	-	H	ko:K00788,ko:K03147,ko:K14153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
DIFFNHDI_01878	1.15e-173	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DIFFNHDI_01879	4.27e-117	gepA	-	-	K	-	-	-	Phage-associated protein
DIFFNHDI_01881	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_01882	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_01883	1.21e-241	-	-	-	E	ko:K07588	-	ko00000,ko01000	ArgK protein
DIFFNHDI_01884	1.82e-112	-	-	-	F	ko:K08311	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	NUDIX domain
DIFFNHDI_01885	0.0	sepA	-	-	Q	-	-	-	COG2015, Alkyl sulfatase and related hydrolases
DIFFNHDI_01886	4.02e-121	-	-	-	-	-	-	-	-
DIFFNHDI_01887	1.71e-110	ruvC	3.1.22.4	-	L	ko:K01159	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DIFFNHDI_01888	1.48e-291	-	-	-	L	-	-	-	helicase superfamily c-terminal domain
DIFFNHDI_01889	1.16e-158	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
DIFFNHDI_01890	8.82e-241	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase
DIFFNHDI_01892	1.69e-107	-	-	-	K	-	-	-	DNA-binding transcription factor activity
DIFFNHDI_01893	4.2e-264	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Biotin-lipoyl like
DIFFNHDI_01894	0.0	-	-	-	V	-	-	-	AcrB/AcrD/AcrF family
DIFFNHDI_01895	8.33e-114	-	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Dihydrofolate reductase
DIFFNHDI_01896	5.77e-208	-	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Thymidylate synthase
DIFFNHDI_01897	0.0	-	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phospholipase D. Active site motifs.
DIFFNHDI_01898	0.0	-	4.1.1.3	-	C	ko:K01571	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	HMGL-like
DIFFNHDI_01900	0.0	-	-	-	V	ko:K03327	-	ko00000,ko02000	MatE
DIFFNHDI_01901	1.23e-255	-	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Iron-sulfur cluster assembly protein
DIFFNHDI_01902	6.78e-42	-	-	-	S	-	-	-	PurA ssDNA and RNA-binding protein
DIFFNHDI_01904	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	LeuA allosteric (dimerisation) domain
DIFFNHDI_01905	0.0	prlC	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
DIFFNHDI_01906	1.58e-282	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIFFNHDI_01907	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIFFNHDI_01908	0.0	-	-	-	MU	ko:K18139	ko01501,ko02024,map01501,map02024	ko00000,ko00001,ko00002,ko01504,ko02000	Outer membrane efflux protein
DIFFNHDI_01910	1.9e-256	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Iron-containing alcohol dehydrogenase
DIFFNHDI_01912	0.0	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
DIFFNHDI_01913	2.16e-180	-	-	-	C	-	-	-	Cytochrome c7 and related cytochrome c
DIFFNHDI_01914	0.0	-	-	-	C	ko:K00184	-	ko00000	4Fe-4S dicluster domain
DIFFNHDI_01916	0.0	-	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	RecG wedge domain
DIFFNHDI_01917	4.02e-166	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
DIFFNHDI_01918	0.0	pckG	4.1.1.32	-	C	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
DIFFNHDI_01920	9.05e-85	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	4'-phosphopantetheinyl transferase superfamily
DIFFNHDI_01921	5.64e-173	pdxJ	2.6.99.2	-	H	ko:K03474	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DIFFNHDI_01922	0.0	-	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	AICARFT/IMPCHase bienzyme
DIFFNHDI_01923	1.06e-94	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L9, N-terminal domain
DIFFNHDI_01924	1.81e-227	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
DIFFNHDI_01925	3.2e-209	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
DIFFNHDI_01926	5e-19	-	-	-	S	-	-	-	Lipocalin-like
DIFFNHDI_01928	8.77e-239	cbiM	-	-	P	ko:K02007,ko:K02009,ko:K16915	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt ion transport
DIFFNHDI_01929	2.82e-194	cbiQ	-	-	P	ko:K02007,ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transmembrane transporter activity
DIFFNHDI_01930	1.96e-178	cbiO	-	-	P	ko:K02006,ko:K02008,ko:K16784,ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPase activity
DIFFNHDI_01931	0.0	-	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	HELICc2
DIFFNHDI_01933	1.84e-206	ispE	2.7.1.148	-	I	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GHMP kinases N terminal domain
DIFFNHDI_01934	0.0	-	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	TopoisomeraseII
DIFFNHDI_01935	1.06e-173	-	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DIFFNHDI_01936	1.98e-258	-	2.7.7.13	-	M	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
DIFFNHDI_01937	2.13e-96	-	-	-	L	ko:K07447	-	ko00000,ko01000	Likely ribonuclease with RNase H fold.
DIFFNHDI_01938	9.07e-234	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
DIFFNHDI_01940	1.45e-55	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L28 family
DIFFNHDI_01941	1.04e-49	-	-	-	-	-	-	-	-
DIFFNHDI_01942	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Alpha galactosidase A
DIFFNHDI_01943	7.5e-221	-	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
DIFFNHDI_01944	0.0	-	-	-	E	-	-	-	Aminotransferase class I and II
DIFFNHDI_01945	4.6e-305	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
DIFFNHDI_01946	1.04e-78	divIC	-	-	D	ko:K05589,ko:K13052	-	ko00000,ko03036	cell cycle
DIFFNHDI_01947	0.0	-	-	-	P	-	-	-	Sulfatase
DIFFNHDI_01950	8.26e-154	-	-	-	K	-	-	-	Transcriptional regulator
DIFFNHDI_01951	7.18e-190	-	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_01952	1.35e-236	-	1.1.1.86	-	E	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIFFNHDI_01953	8.5e-121	-	-	-	M	ko:K03098	-	ko00000,ko04147	Lipocalin-like domain
DIFFNHDI_01954	2.34e-207	-	-	-	S	ko:K07071	-	ko00000	Domain of unknown function (DUF1731)
DIFFNHDI_01955	5.75e-202	-	-	-	O	-	-	-	stress-induced mitochondrial fusion
DIFFNHDI_01957	9.45e-239	-	-	-	E	-	-	-	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DIFFNHDI_01959	4.24e-296	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
DIFFNHDI_01960	1.49e-237	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
DIFFNHDI_01961	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_01962	1.78e-241	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
DIFFNHDI_01963	0.0	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIFFNHDI_01964	4.72e-207	-	-	-	S	-	-	-	Protein of unknown function DUF58
DIFFNHDI_01965	0.0	-	-	-	S	-	-	-	Aerotolerance regulator N-terminal
DIFFNHDI_01966	0.0	-	-	-	S	-	-	-	von Willebrand factor type A domain
DIFFNHDI_01967	1.78e-293	-	-	-	-	-	-	-	-
DIFFNHDI_01968	2e-259	-	4.1.2.48	-	E	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Beta-eliminating lyase
DIFFNHDI_01969	6.71e-90	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DIFFNHDI_01970	1.02e-282	-	-	-	C	-	-	-	Aldo/keto reductase family
DIFFNHDI_01971	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
DIFFNHDI_01972	6e-142	-	-	-	K	ko:K03088	-	ko00000,ko03021	DNA-templated transcription, initiation
DIFFNHDI_01973	7.19e-197	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
DIFFNHDI_01975	6.41e-236	-	2.7.11.1	-	T	ko:K08884,ko:K12132,ko:K20333	ko02024,map02024	ko00000,ko00001,ko01000,ko01001	PFAM Formylglycine-generating sulfatase enzyme
DIFFNHDI_01976	1.11e-262	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
DIFFNHDI_01978	2.54e-132	kdpC	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DIFFNHDI_01979	0.0	kdpB	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DIFFNHDI_01980	0.0	kdpA	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DIFFNHDI_01981	9.27e-75	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_01988	1.25e-87	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_01991	0.0	-	-	-	G	-	-	-	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
DIFFNHDI_01992	0.000651	-	-	-	-	-	-	-	-
DIFFNHDI_01993	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
DIFFNHDI_01994	5.46e-189	-	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
DIFFNHDI_01996	0.0	-	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	DHHA2
DIFFNHDI_01997	1.89e-253	-	-	-	N	ko:K18353	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01504	Endonuclease Exonuclease Phosphatase
DIFFNHDI_01998	8.25e-63	-	-	-	L	ko:K09747	-	ko00000	YbaB/EbfC DNA-binding family
DIFFNHDI_01999	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DIFFNHDI_02001	4.03e-174	-	-	-	D	-	-	-	Phage-related minor tail protein
DIFFNHDI_02003	1.69e-174	-	-	-	L	ko:K03630	-	ko00000	RadC-like JAB domain
DIFFNHDI_02004	0.0	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DIFFNHDI_02005	6.12e-40	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DIFFNHDI_02006	2.79e-97	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DIFFNHDI_02007	1.67e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S9/S16
DIFFNHDI_02008	1.27e-99	-	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Predicted SPOUT methyltransferase
DIFFNHDI_02009	0.0	-	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
DIFFNHDI_02010	6.34e-183	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
DIFFNHDI_02011	6.23e-97	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
DIFFNHDI_02012	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_02013	0.0	-	-	-	M	-	-	-	PFAM glycosyl transferase family 51
DIFFNHDI_02014	6.64e-185	-	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase family
DIFFNHDI_02015	1.93e-117	ispF	4.6.1.12	-	I	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
DIFFNHDI_02016	1.29e-181	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
DIFFNHDI_02017	3.4e-229	-	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphomannose isomerase type I
DIFFNHDI_02018	1.11e-236	-	-	-	-	-	-	-	-
DIFFNHDI_02019	8.01e-294	-	-	-	C	-	-	-	Na+/H+ antiporter family
DIFFNHDI_02020	1.31e-268	fcl	1.1.1.271	-	GM	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
DIFFNHDI_02021	6.96e-265	-	4.2.1.47	-	M	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DIFFNHDI_02022	3.11e-272	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase small chain, CPSase domain
DIFFNHDI_02023	0.0	-	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
DIFFNHDI_02024	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
DIFFNHDI_02025	0.0	-	1.4.1.13, 1.4.1.14	-	E	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	GXGXG motif
DIFFNHDI_02026	0.0	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
DIFFNHDI_02027	1.09e-59	-	-	-	S	ko:K08998	-	ko00000	Haemolytic
DIFFNHDI_02028	4.9e-76	-	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	Ribonuclease P
DIFFNHDI_02029	1.1e-34	-	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L34
DIFFNHDI_02030	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
DIFFNHDI_02031	0.0	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
DIFFNHDI_02032	0.0	-	-	-	G	-	-	-	Trehalase
DIFFNHDI_02033	2.45e-211	-	5.1.3.15	-	G	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Aldose 1-epimerase
DIFFNHDI_02034	3.45e-157	-	1.4.3.5	-	H	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
DIFFNHDI_02035	1.19e-199	-	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate phosphoribosyl transferase, N-terminal domain
DIFFNHDI_02036	2.63e-208	-	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Polyprenyl synthetase
DIFFNHDI_02037	9.55e-242	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DIFFNHDI_02039	1.11e-175	-	-	-	-	-	-	-	-
DIFFNHDI_02040	0.0	-	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase alpha chain
DIFFNHDI_02041	7.15e-221	-	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Pyridine nucleotide-disulphide oxidoreductase
DIFFNHDI_02042	2.11e-219	-	-	-	E	ko:K00612	-	ko00000,ko01000	lipolytic protein G-D-S-L family
DIFFNHDI_02043	1.14e-134	panZ	-	-	K	-	-	-	-acetyltransferase
DIFFNHDI_02049	1.2e-167	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
DIFFNHDI_02050	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
DIFFNHDI_02051	2.09e-207	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
DIFFNHDI_02052	2.46e-272	-	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	Thermophilic metalloprotease (M29)
DIFFNHDI_02053	4.4e-138	-	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DIFFNHDI_02054	3.01e-188	-	5.2.1.8	-	O	ko:K03773	-	ko00000,ko01000,ko03110	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
DIFFNHDI_02064	0.0	-	-	-	V	-	-	-	MatE
DIFFNHDI_02065	4.33e-161	menG	2.1.1.163, 2.1.1.201	-	Q	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	ubiE/COQ5 methyltransferase family
DIFFNHDI_02069	7.53e-201	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DIFFNHDI_02070	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DIFFNHDI_02071	1.3e-210	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
DIFFNHDI_02072	3.95e-252	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DIFFNHDI_02074	1.37e-306	-	-	-	E	ko:K03310	-	ko00000	Sodium:alanine symporter family
DIFFNHDI_02075	2.43e-95	-	-	-	K	-	-	-	-acetyltransferase
DIFFNHDI_02076	8.6e-222	-	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Glutaminase
DIFFNHDI_02077	0.0	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	amino acid
DIFFNHDI_02078	0.0	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_02079	2.79e-114	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_02082	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Prolyl-tRNA synthetase, C-terminal
DIFFNHDI_02083	2.04e-158	-	-	-	S	-	-	-	Peptidase family M50
DIFFNHDI_02085	2.27e-215	-	-	-	JM	-	-	-	Nucleotidyl transferase
DIFFNHDI_02086	8.25e-273	-	-	-	S	-	-	-	Phosphotransferase enzyme family
DIFFNHDI_02087	1.01e-222	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
DIFFNHDI_02089	0.0	-	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
DIFFNHDI_02090	5.87e-296	-	-	-	-	-	-	-	-
DIFFNHDI_02091	0.0	-	-	-	-	-	-	-	-
DIFFNHDI_02092	1.03e-138	mntP	-	-	P	-	-	-	manganese ion transmembrane transporter activity
DIFFNHDI_02094	4.17e-190	-	-	-	S	-	-	-	Phenazine biosynthesis-like protein
DIFFNHDI_02095	9.46e-176	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
DIFFNHDI_02096	0.0	-	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	Sigma-54 factor, Activator interacting domain (AID)
DIFFNHDI_02097	5.48e-273	ycaD	-	-	EGP	ko:K08219	-	ko00000,ko02000	Major facilitator Superfamily
DIFFNHDI_02098	4.27e-225	-	3.4.11.10, 3.4.11.6	-	DZ	ko:K19701	-	ko00000,ko01000,ko01002	aminopeptidase activity
DIFFNHDI_02099	1.16e-287	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
DIFFNHDI_02100	0.0	-	-	-	S	-	-	-	inositol 2-dehydrogenase activity
DIFFNHDI_02102	6.73e-286	-	3.6.4.13	-	L	ko:K11927	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	helicase superfamily c-terminal domain
DIFFNHDI_02104	3.6e-145	-	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	CDP-alcohol phosphatidyltransferase
DIFFNHDI_02105	0.0	-	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DIFFNHDI_02106	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
DIFFNHDI_02107	9.77e-278	-	4.2.1.51, 5.4.99.5	-	E	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase type II
DIFFNHDI_02108	3.72e-237	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
DIFFNHDI_02109	1.91e-191	-	-	-	S	-	-	-	NIF3 (NGG1p interacting factor 3)
DIFFNHDI_02110	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4340)
DIFFNHDI_02111	0.0	-	-	-	N	-	-	-	ABC-type uncharacterized transport system
DIFFNHDI_02112	1.01e-182	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
DIFFNHDI_02113	1.09e-223	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
DIFFNHDI_02114	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DIFFNHDI_02115	2.38e-133	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	nUDIX hydrolase
DIFFNHDI_02117	1.52e-40	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
DIFFNHDI_02118	2.16e-21	traC	-	-	P	-	-	-	DNA integration
DIFFNHDI_02119	1.49e-06	-	-	-	L	ko:K07505	-	ko00000	Primase C terminal 2 (PriCT-2)
DIFFNHDI_02120	8.98e-73	-	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
DIFFNHDI_02122	1.43e-09	-	2.1.1.37	-	H	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	C-5 cytosine-specific DNA methylase
DIFFNHDI_02123	6.4e-26	-	-	-	-	-	-	-	-
DIFFNHDI_02131	2.74e-06	-	-	-	-	-	-	-	-
DIFFNHDI_02133	1.09e-12	-	-	-	K	ko:K07726	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
DIFFNHDI_02134	5.83e-30	-	-	-	M	-	-	-	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_02138	8.51e-42	-	-	-	S	ko:K07114	-	ko00000,ko02000	von Willebrand factor (vWF) type A domain
DIFFNHDI_02139	0.0	-	-	-	S	-	-	-	Oxygen tolerance
DIFFNHDI_02140	1.16e-205	yeaE	-	-	S	-	-	-	aldo-keto reductase (NADP) activity
DIFFNHDI_02141	0.0	-	6.1.1.14	-	J	ko:K01880	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Anticodon binding domain
DIFFNHDI_02142	3.7e-156	-	-	-	S	-	-	-	DUF218 domain
DIFFNHDI_02143	1.93e-209	-	-	-	S	-	-	-	CAAX protease self-immunity
DIFFNHDI_02144	1.59e-286	-	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Cys/Met metabolism PLP-dependent enzyme
DIFFNHDI_02145	8.26e-106	-	-	-	K	-	-	-	Lrp/AsnC ligand binding domain
DIFFNHDI_02146	0.0	-	-	-	L	-	-	-	SNF2 family N-terminal domain
DIFFNHDI_02147	8.46e-84	-	-	-	P	ko:K06195	-	ko00000	ApaG domain
DIFFNHDI_02148	7.47e-203	-	-	-	-	-	-	-	-
DIFFNHDI_02149	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
DIFFNHDI_02150	6.07e-192	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
DIFFNHDI_02151	1.88e-135	-	-	-	K	ko:K07735	-	ko00000,ko03000	Uncharacterized ACR, COG1678
DIFFNHDI_02152	4.14e-163	-	-	-	S	ko:K06997	-	ko00000	Alanine racemase, N-terminal domain
DIFFNHDI_02153	0.0	-	-	-	S	-	-	-	50S ribosome-binding GTPase
DIFFNHDI_02154	1.36e-137	-	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	5-formyltetrahydrofolate cyclo-ligase family
DIFFNHDI_02155	8.83e-209	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_02156	0.0	-	-	-	E	-	-	-	Peptidase dimerisation domain
DIFFNHDI_02157	3.12e-223	hprK	-	-	T	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
DIFFNHDI_02158	8.72e-53	-	-	-	G	ko:K11189	-	ko00000,ko02000	PTS HPr component phosphorylation site
DIFFNHDI_02159	0.0	-	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DIFFNHDI_02160	0.0	-	-	-	P	-	-	-	Sulfatase
DIFFNHDI_02161	1.64e-223	-	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DIFFNHDI_02162	1.45e-93	-	-	-	S	ko:K02426	-	ko00000	Fe-S metabolism associated domain
DIFFNHDI_02164	0.0	-	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha amylase, C-terminal all-beta domain
DIFFNHDI_02165	4.15e-262	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
DIFFNHDI_02166	0.0	cobD	2.6.1.9, 2.7.7.74, 4.1.1.81	-	M	ko:K00817,ko:K04720,ko:K07281	ko00340,ko00350,ko00360,ko00400,ko00401,ko00562,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00562,map00860,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	nucleotidyl transferase
DIFFNHDI_02167	1.5e-95	-	4.3.1.12	-	E	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	ko00000,ko00001,ko01000	Ornithine cyclodeaminase/mu-crystallin family
DIFFNHDI_02168	0.0	-	2.7.7.15	-	H	ko:K00968	ko00440,ko00564,ko01100,ko05231,map00440,map00564,map01100,map05231	ko00000,ko00001,ko00002,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
DIFFNHDI_02169	1.14e-229	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
DIFFNHDI_02170	1.45e-29	-	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	PFAM glycosyltransferase sugar-binding region containing DXD motif
DIFFNHDI_02171	9.89e-66	tagD	2.7.7.39	-	H	ko:K00980	ko00564,map00564	ko00000,ko00001,ko01000	Glycerol-3-phosphate cytidylyltransferase
DIFFNHDI_02172	2.46e-45	-	-	-	M	ko:K07271	-	ko00000,ko01000	LicD family
DIFFNHDI_02173	1.69e-127	-	-	-	S	-	-	-	protein trimerization
DIFFNHDI_02175	1.84e-183	-	2.1.1.144, 2.1.1.197	-	FG	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	trans-aconitate 2-methyltransferase activity
DIFFNHDI_02176	0.0	-	2.7.7.9	-	G	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP--glucose-1-phosphate uridylyltransferase
DIFFNHDI_02177	1.67e-123	-	-	-	-	-	-	-	-
DIFFNHDI_02178	3.09e-61	-	-	-	J	-	-	-	RF-1 domain
DIFFNHDI_02179	1.79e-122	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DIFFNHDI_02180	1.28e-276	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
DIFFNHDI_02181	4.43e-291	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
DIFFNHDI_02182	9.6e-79	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
DIFFNHDI_02183	6.63e-144	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
DIFFNHDI_02184	5.87e-163	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
DIFFNHDI_02185	8.71e-301	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
DIFFNHDI_02186	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
DIFFNHDI_02188	3.29e-146	-	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DIFFNHDI_02189	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIFFNHDI_02191	4.89e-237	-	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Delta-aminolevulinic acid dehydratase
DIFFNHDI_02193	2.04e-160	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
DIFFNHDI_02194	0.0	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
DIFFNHDI_02195	1.72e-230	-	4.1.1.35	-	M	ko:K08678	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko00002,ko01000	3-beta hydroxysteroid dehydrogenase/isomerase family
DIFFNHDI_02196	2.15e-183	-	-	-	I	-	-	-	Acyl-ACP thioesterase
DIFFNHDI_02197	0.0	-	-	-	T	-	-	-	pathogenesis
DIFFNHDI_02198	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
DIFFNHDI_02199	5.33e-114	ywrF	-	-	S	-	-	-	FMN binding
DIFFNHDI_02200	9.27e-86	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
DIFFNHDI_02201	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
DIFFNHDI_02202	3.11e-306	-	-	-	M	-	-	-	OmpA family
DIFFNHDI_02203	0.0	-	6.3.2.45	-	M	ko:K02558	-	ko00000,ko01000	Mur ligase family, catalytic domain
DIFFNHDI_02204	6.55e-221	-	-	-	E	-	-	-	Phosphoserine phosphatase
DIFFNHDI_02205	6.31e-171	-	-	-	S	ko:K06861	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
DIFFNHDI_02208	6.68e-198	-	2.5.1.55	-	M	ko:K01627	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	DAHP synthetase I family
DIFFNHDI_02209	9.04e-171	cbiX	4.99.1.3	-	S	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	sirohydrochlorin cobaltochelatase activity
DIFFNHDI_02210	5.88e-163	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S2
DIFFNHDI_02211	7.15e-199	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DIFFNHDI_02212	2.65e-174	-	-	-	E	-	-	-	ATPases associated with a variety of cellular activities
DIFFNHDI_02214	4.53e-284	-	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	3-dehydroquinate synthase
DIFFNHDI_02215	0.0	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
DIFFNHDI_02216	0.0	-	-	-	O	-	-	-	Trypsin
DIFFNHDI_02217	4.99e-274	-	-	-	-	-	-	-	-
DIFFNHDI_02218	1.53e-146	-	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
DIFFNHDI_02219	0.0	-	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase family (aconitate hydratase)
DIFFNHDI_02220	7.14e-141	-	2.3.1.181	-	H	ko:K03801	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
DIFFNHDI_02221	1.92e-238	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
DIFFNHDI_02222	1.15e-238	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DIFFNHDI_02223	1.8e-216	-	-	-	M	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	POTRA domain, FtsQ-type
DIFFNHDI_02224	4.13e-228	ddl	6.3.2.4	-	M	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	D-ala D-ala ligase N-terminus
DIFFNHDI_02225	0.0	murB	-	-	M	-	-	-	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
DIFFNHDI_02226	3.91e-267	-	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DIFFNHDI_02227	1.33e-277	-	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Cell cycle protein
DIFFNHDI_02228	8.21e-160	mltD	-	CBM50	M	ko:K08307,ko:K12204,ko:K19224	-	ko00000,ko01000,ko01002,ko01011,ko02044	LysM domain
DIFFNHDI_02229	2.48e-315	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DIFFNHDI_02230	8.1e-261	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIFFNHDI_02231	0.0	-	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Mur ligase middle domain
DIFFNHDI_02232	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIFFNHDI_02233	0.0	-	3.4.16.4	-	M	ko:K03587	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011,ko03036	Penicillin-binding Protein dimerisation domain
DIFFNHDI_02235	0.0	rsmH	2.1.1.199	-	M	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
DIFFNHDI_02236	4.54e-105	-	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
DIFFNHDI_02237	5.27e-189	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
DIFFNHDI_02238	2.82e-154	-	-	-	S	-	-	-	UPF0126 domain
DIFFNHDI_02239	3.95e-13	-	-	-	S	-	-	-	Mac 1
DIFFNHDI_02240	8.55e-193	-	-	-	B	-	-	-	positive regulation of histone acetylation
DIFFNHDI_02241	7.91e-305	mnmE	-	-	J	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DIFFNHDI_02242	2.72e-263	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
DIFFNHDI_02243	1.24e-195	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DIFFNHDI_02244	2.94e-184	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
DIFFNHDI_02245	4.96e-271	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
DIFFNHDI_02246	1.77e-142	-	-	-	S	-	-	-	Hexapeptide repeat of succinyl-transferase
DIFFNHDI_02247	6.03e-270	-	-	-	M	-	-	-	Glycosyl transferases group 1
DIFFNHDI_02248	2.21e-264	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
DIFFNHDI_02249	0.0	-	-	-	S	-	-	-	polysaccharide biosynthetic process
DIFFNHDI_02250	1.29e-187	-	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	2Fe-2S iron-sulfur cluster binding domain
DIFFNHDI_02251	0.0	-	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
DIFFNHDI_02252	4.83e-163	-	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	-
DIFFNHDI_02253	8.94e-56	-	-	-	-	-	-	-	-
DIFFNHDI_02254	1.43e-194	-	-	-	S	ko:K07051	-	ko00000	TatD related DNase
DIFFNHDI_02255	7.45e-49	XK27_09985	-	-	S	-	-	-	Protein of unknown function (DUF1232)
DIFFNHDI_02257	0.000576	-	-	-	-	-	-	-	-
DIFFNHDI_02259	1.6e-22	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
DIFFNHDI_02260	7.5e-306	-	-	-	C	-	-	-	Sulfatase-modifying factor enzyme 1
DIFFNHDI_02261	2.07e-169	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	KR domain
DIFFNHDI_02263	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
DIFFNHDI_02264	2.98e-08	-	-	-	M	-	-	-	major outer membrane lipoprotein
DIFFNHDI_02266	4.21e-137	-	-	-	J	ko:K05808	-	ko00000,ko03009	Sigma 54 modulation/S30EA ribosomal protein C terminus
DIFFNHDI_02268	1.55e-24	corC_1	-	-	P	ko:K03699	-	ko00000,ko02042	Transporter associated domain
DIFFNHDI_02269	2.41e-158	-	-	-	IQ	-	-	-	Short chain dehydrogenase
DIFFNHDI_02270	2.77e-308	-	-	-	C	-	-	-	Carboxymuconolactone decarboxylase family
DIFFNHDI_02271	2.9e-275	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
DIFFNHDI_02272	8.36e-186	-	-	-	S	-	-	-	Alpha/beta hydrolase family
DIFFNHDI_02273	6.03e-178	-	-	-	C	-	-	-	aldo keto reductase
DIFFNHDI_02274	1.05e-219	-	-	-	K	-	-	-	Transcriptional regulator
DIFFNHDI_02275	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
DIFFNHDI_02276	1.17e-304	-	-	-	C	-	-	-	4 iron, 4 sulfur cluster binding
DIFFNHDI_02277	1.88e-111	-	-	-	KT	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
DIFFNHDI_02278	2.59e-174	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
DIFFNHDI_02279	1.96e-184	-	-	-	-	-	-	-	-
DIFFNHDI_02280	8.46e-133	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
DIFFNHDI_02281	1.24e-51	-	-	-	-	-	-	-	-
DIFFNHDI_02283	1.46e-75	-	-	-	S	ko:K09954	-	ko00000	Putative quorum-sensing-regulated virulence factor
DIFFNHDI_02284	5.94e-178	-	4.2.99.20	-	I	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Alpha/beta hydrolase family
DIFFNHDI_02285	1.39e-128	-	-	-	U	ko:K05595	-	ko00000,ko02000	MarC family integral membrane protein
DIFFNHDI_02289	2.93e-233	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
DIFFNHDI_02292	7.48e-188	-	-	-	O	ko:K04083	-	ko00000,ko03110	Hsp33 protein
DIFFNHDI_02293	1.47e-120	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIFFNHDI_02294	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
DIFFNHDI_02295	6.7e-132	-	-	-	-	-	-	-	-
DIFFNHDI_02296	3.32e-210	ybfH	-	-	EG	-	-	-	spore germination
DIFFNHDI_02297	1.6e-75	-	-	-	G	-	-	-	Cupin 2, conserved barrel domain protein
DIFFNHDI_02298	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
DIFFNHDI_02299	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
DIFFNHDI_02300	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
DIFFNHDI_02301	9.83e-235	-	-	-	CO	-	-	-	Thioredoxin-like
DIFFNHDI_02303	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
DIFFNHDI_02304	6.21e-39	-	-	-	-	-	-	-	-
DIFFNHDI_02306	4.25e-160	-	-	-	S	-	-	-	Terminase
DIFFNHDI_02308	1.72e-41	-	-	-	-	-	-	-	-
DIFFNHDI_02314	1.54e-305	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
DIFFNHDI_02326	1.04e-65	-	-	-	KT	-	-	-	Peptidase S24-like
DIFFNHDI_02328	4.93e-64	-	-	-	F	-	-	-	acetyltransferase
DIFFNHDI_02329	4.71e-33	-	-	-	M	-	-	-	lytic transglycosylase activity
DIFFNHDI_02335	3.4e-178	-	-	-	O	-	-	-	Trypsin
DIFFNHDI_02336	3.31e-239	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
DIFFNHDI_02337	6.2e-203	-	-	-	-	-	-	-	-
DIFFNHDI_02338	0.0	-	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
DIFFNHDI_02339	2.74e-284	-	-	-	S	-	-	-	Tetratricopeptide repeat
DIFFNHDI_02341	2.63e-10	-	-	-	-	-	-	-	-
DIFFNHDI_02343	8.23e-62	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DIFFNHDI_02344	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
DIFFNHDI_02345	2.48e-228	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
DIFFNHDI_02346	1.26e-210	-	-	-	S	-	-	-	Protein of unknown function DUF58
DIFFNHDI_02347	8.06e-134	-	-	-	-	-	-	-	-
DIFFNHDI_02348	2.3e-229	-	-	-	S	-	-	-	Protein of unknown function (DUF1194)
DIFFNHDI_02362	2.51e-103	-	-	-	K	-	-	-	DNA-binding transcription factor activity
DIFFNHDI_02363	3.03e-231	-	-	-	J	-	-	-	Belongs to the universal ribosomal protein uS2 family
DIFFNHDI_02364	2.13e-230	-	-	-	L	-	-	-	Elongator protein 3, MiaB family, Radical SAM
DIFFNHDI_02365	4.72e-153	-	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
DIFFNHDI_02366	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
DIFFNHDI_02368	7.65e-101	-	-	-	M	ko:K06077	-	ko00000	Glycine zipper 2TM domain
DIFFNHDI_02369	6.15e-234	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Converts alpha-aldose to the beta-anomer
DIFFNHDI_02370	1.75e-139	-	-	-	P	ko:K02039	-	ko00000	PhoU domain
DIFFNHDI_02371	5.24e-185	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
DIFFNHDI_02372	1.51e-221	-	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	PBP superfamily domain
DIFFNHDI_02373	0.0	pstC	-	-	P	ko:K02037,ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_02374	0.0	-	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
DIFFNHDI_02375	8.04e-184	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
DIFFNHDI_02376	1.33e-151	phoU	-	-	P	ko:K02039	-	ko00000	negative regulation of phosphate transmembrane transport
DIFFNHDI_02378	6.9e-282	-	-	-	J	-	-	-	PFAM Endoribonuclease L-PSP
DIFFNHDI_02379	0.0	-	-	-	C	-	-	-	cytochrome C peroxidase
DIFFNHDI_02380	0.0	-	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
DIFFNHDI_02381	1e-20	-	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	COG0010 Arginase agmatinase formimionoglutamate hydrolase arginase family
DIFFNHDI_02382	1.02e-296	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase family U32
DIFFNHDI_02383	2.66e-147	-	-	-	C	-	-	-	lactate oxidation
DIFFNHDI_02384	0.0	-	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	DNA Topoisomerase IV
DIFFNHDI_02385	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIFFNHDI_02387	0.0	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
DIFFNHDI_02388	1.85e-149	-	-	-	-	-	-	-	-
DIFFNHDI_02391	1.34e-109	ptsN	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIFFNHDI_02392	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
DIFFNHDI_02393	2.47e-253	-	-	-	L	-	-	-	Transposase IS200 like
DIFFNHDI_02394	0.0	-	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
DIFFNHDI_02395	7.89e-268	-	2.4.1.182	GT19	M	ko:K00748	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIFFNHDI_02396	1.58e-148	dedA	-	-	S	-	-	-	FtsZ-dependent cytokinesis
DIFFNHDI_02397	1.3e-116	-	-	-	S	-	-	-	nitrogen fixation
DIFFNHDI_02398	6.22e-74	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DIFFNHDI_02399	1.04e-83	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DIFFNHDI_02400	1.26e-112	-	-	-	CO	-	-	-	cell redox homeostasis
DIFFNHDI_02402	1.5e-180	-	-	-	-	-	-	-	-
DIFFNHDI_02404	0.0	-	-	-	S	-	-	-	Bacteriophage head to tail connecting protein
DIFFNHDI_02406	2.33e-143	-	-	-	-	-	-	-	-
DIFFNHDI_02407	6.96e-64	-	-	-	K	-	-	-	DNA-binding transcription factor activity
DIFFNHDI_02410	1.69e-06	-	-	-	-	-	-	-	-
DIFFNHDI_02411	0.0	-	-	-	G	-	-	-	Glycosyl hydrolases family 18
DIFFNHDI_02412	0.0	-	-	-	S	ko:K07126,ko:K13582	ko04112,map04112	ko00000,ko00001	beta-lactamase activity
DIFFNHDI_02414	6.58e-276	-	6.2.1.26	-	IQ	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	AMP-binding enzyme
DIFFNHDI_02415	1.27e-70	-	-	-	K	-	-	-	ribonuclease III activity
DIFFNHDI_02416	1.55e-164	-	-	-	-	-	-	-	-
DIFFNHDI_02417	3.49e-139	nuoC	1.6.5.3	-	C	ko:K00332	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_02418	3.77e-138	nuoB	1.6.5.3	-	C	ko:K00331	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIFFNHDI_02422	5.17e-28	-	-	-	M	-	-	-	self proteolysis
DIFFNHDI_02428	1.55e-162	-	-	-	D	-	-	-	AAA domain
DIFFNHDI_02429	1.95e-81	-	-	-	S	-	-	-	AAA domain
DIFFNHDI_02431	2.78e-229	-	3.1.21.5	-	L	ko:K01156	-	ko00000,ko01000,ko02048	the current gene model (or a revised gene model) may contain a frame shift
DIFFNHDI_02432	7.97e-156	-	-	-	L	ko:K07505	-	ko00000	Primase C terminal 2 (PriCT-2)
DIFFNHDI_02433	4.05e-35	rusA	-	-	L	-	-	-	Endodeoxyribonuclease RusA
DIFFNHDI_02452	3.81e-81	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Belongs to the N(4) N(6)-methyltransferase family
DIFFNHDI_02456	4.52e-37	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
DIFFNHDI_02466	5.16e-70	-	-	-	M	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_02467	1.5e-215	-	-	-	L	-	-	-	Transposase
DIFFNHDI_02468	2.34e-104	-	-	-	S	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_02469	1.06e-24	-	-	-	D	ko:K19159	-	ko00000,ko02048	Antitoxin component of a toxin-antitoxin (TA) module
DIFFNHDI_02470	5.84e-28	-	-	-	S	ko:K19158	-	ko00000,ko01000,ko02048	addiction module toxin, Txe YoeB family
DIFFNHDI_02471	2.23e-28	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
DIFFNHDI_02474	4.56e-270	-	-	-	L	-	-	-	Transposase IS66 family
DIFFNHDI_02475	4.91e-53	-	-	-	-	-	-	-	-
DIFFNHDI_02476	9.68e-83	-	-	-	L	ko:K07484	-	ko00000	PFAM IS66 Orf2 like protein
DIFFNHDI_02478	6.93e-141	-	-	-	K	-	-	-	Fic/DOC family
DIFFNHDI_02479	1.36e-168	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
DIFFNHDI_02480	4.55e-15	-	-	-	-	-	-	-	-
DIFFNHDI_02481	4.7e-90	-	-	-	L	ko:K07484	-	ko00000	IS66 Orf2 like protein
DIFFNHDI_02482	0.0	-	-	-	L	ko:K07484	-	ko00000	Transposase IS66 family
DIFFNHDI_02483	7.1e-36	-	-	-	S	-	-	-	COG NOG20805 non supervised orthologous group
DIFFNHDI_02484	5.4e-81	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Belongs to the N(4) N(6)-methyltransferase family
DIFFNHDI_02486	9.06e-16	-	-	-	K	-	-	-	Helix-turn-helix XRE-family like proteins
DIFFNHDI_02487	4.7e-34	-	3.4.21.88	-	K	ko:K01356	-	ko00000,ko00002,ko01000,ko01002,ko03400	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DIFFNHDI_02488	7.03e-16	-	-	-	N	-	-	-	Periplasmic or secreted lipoprotein
DIFFNHDI_02489	3.34e-26	-	-	-	S	-	-	-	HicB_like antitoxin of bacterial toxin-antitoxin system
DIFFNHDI_02490	4.83e-25	-	-	-	K	-	-	-	Peptidase S24-like
DIFFNHDI_02498	6.58e-199	-	-	-	L	-	-	-	Psort location Cytoplasmic, score
DIFFNHDI_02500	1.27e-46	-	-	-	S	-	-	-	Domain of unknown function (DUF4315)
DIFFNHDI_02501	2.39e-199	-	-	-	L	-	-	-	Transposase
DIFFNHDI_02504	8.25e-105	-	-	-	U	ko:K01992,ko:K09690	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Transport permease protein
DIFFNHDI_02506	2.34e-201	-	-	-	L	-	-	-	Transposase DDE domain group 1
DIFFNHDI_02508	2.61e-125	-	-	-	-	-	-	-	-
DIFFNHDI_02512	4.46e-184	-	-	-	L	-	-	-	Bacterial dnaA protein
DIFFNHDI_02513	4.15e-209	-	-	-	L	-	-	-	PFAM integrase
DIFFNHDI_02516	8.68e-36	-	-	-	S	-	-	-	Transposon-encoded protein TnpW
DIFFNHDI_02517	2.45e-228	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
DIFFNHDI_02518	2.45e-91	-	-	-	L	-	-	-	Transposase