Read a JSON File

ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
KOFIEAFP_00006	5.12e-50	-	-	-	S	-	-	-	AAA domain
KOFIEAFP_00013	3.6e-73	-	-	-	KT	-	-	-	Peptidase S24-like
KOFIEAFP_00014	3.15e-123	-	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	C-5 cytosine-specific DNA methylase
KOFIEAFP_00015	7.73e-134	-	-	-	V	-	-	-	Protein of unknown function DUF262
KOFIEAFP_00016	1.07e-37	-	-	-	-	-	-	-	-
KOFIEAFP_00019	2.78e-06	-	-	-	L	-	-	-	Protein of unknown function (DUF1524)
KOFIEAFP_00023	2.98e-71	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
KOFIEAFP_00025	3.15e-103	-	-	-	J	-	-	-	YjgF/chorismate_mutase-like, putative endoribonuclease
KOFIEAFP_00026	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00027	2.46e-113	-	1.16.3.2	-	P	ko:K02217	-	ko00000,ko01000	Ferritin-like domain
KOFIEAFP_00029	4.98e-92	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
KOFIEAFP_00030	1.25e-307	-	4.2.1.20	-	E	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KOFIEAFP_00031	1.69e-232	-	2.7.1.221	-	S	ko:K07102	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Phosphotransferase enzyme family
KOFIEAFP_00032	0.0	-	-	-	T	-	-	-	Chase2 domain
KOFIEAFP_00033	2.34e-107	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
KOFIEAFP_00034	2.7e-113	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_00035	0.0	-	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit I
KOFIEAFP_00036	1.72e-244	-	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit II
KOFIEAFP_00037	0.0	-	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoglutarate dehydrogenase C-terminal
KOFIEAFP_00038	5.35e-232	-	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
KOFIEAFP_00039	4.66e-59	-	3.4.11.5	-	S	ko:K01259	ko00330,map00330	ko00000,ko00001,ko01000,ko01002	nucleotidyltransferase activity
KOFIEAFP_00040	1.31e-94	-	-	-	S	-	-	-	Nucleotidyltransferase substrate binding protein like
KOFIEAFP_00041	0.0	-	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
KOFIEAFP_00042	9.45e-317	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
KOFIEAFP_00043	6.65e-160	-	-	-	M	ko:K16079	-	ko00000,ko02000	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KOFIEAFP_00045	0.0	-	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
KOFIEAFP_00046	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
KOFIEAFP_00047	0.0	-	-	-	H	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
KOFIEAFP_00048	0.0	cobQ	-	-	H	-	-	-	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
KOFIEAFP_00049	1.11e-237	cobD	6.3.1.10	-	H	ko:K02227	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KOFIEAFP_00050	1.99e-239	cobT	2.4.2.21	-	H	ko:K00768	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KOFIEAFP_00051	1.62e-172	cobS	2.7.8.26	-	H	ko:K02233	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KOFIEAFP_00052	5.75e-207	-	-	-	G	-	-	-	myo-inosose-2 dehydratase activity
KOFIEAFP_00053	4.46e-127	cobU	2.7.1.156, 2.7.7.62, 6.3.5.10	-	H	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	cobinamide kinase activity
KOFIEAFP_00057	2.18e-269	-	-	-	K	-	-	-	Periplasmic binding protein-like domain
KOFIEAFP_00058	4.99e-214	-	-	-	M	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
KOFIEAFP_00059	3.87e-301	-	2.7.1.11, 2.7.1.90	-	H	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
KOFIEAFP_00061	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_00062	0.0	rarA	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
KOFIEAFP_00063	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
KOFIEAFP_00064	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
KOFIEAFP_00065	1.88e-161	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
KOFIEAFP_00066	1.65e-268	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
KOFIEAFP_00067	0.0	-	4.1.1.19	-	E	ko:K01585	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
KOFIEAFP_00068	5.03e-299	-	4.1.1.96	-	E	ko:K13747	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Pyridoxal-dependent decarboxylase, C-terminal sheet domain
KOFIEAFP_00070	0.0	-	-	-	P	-	-	-	Sulfatase
KOFIEAFP_00071	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Leucyl-tRNA synthetase, Domain 2
KOFIEAFP_00072	2.22e-151	-	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribulose-phosphate 3 epimerase family
KOFIEAFP_00073	3.25e-223	-	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Phosphatidylserine decarboxylase
KOFIEAFP_00076	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
KOFIEAFP_00077	3.88e-140	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
KOFIEAFP_00078	2.34e-43	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S20
KOFIEAFP_00080	1.31e-289	-	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	LytB protein
KOFIEAFP_00081	8.69e-261	-	-	-	J	ko:K05541	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KOFIEAFP_00082	2.94e-285	-	-	-	E	-	-	-	Transglutaminase-like superfamily
KOFIEAFP_00083	1.58e-203	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
KOFIEAFP_00084	1.18e-181	-	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
KOFIEAFP_00085	7.21e-203	folD	1.5.1.5, 3.5.4.9	-	H	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KOFIEAFP_00086	7.21e-183	-	-	-	S	ko:K09778	-	ko00000	Domain of unknown function (DUF374)
KOFIEAFP_00087	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00088	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
KOFIEAFP_00089	0.0	-	-	-	G	-	-	-	Alpha amylase, catalytic domain
KOFIEAFP_00090	0.0	-	2.7.7.19	-	J	ko:K00970	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Poly A polymerase head domain
KOFIEAFP_00091	4.13e-312	-	-	-	O	-	-	-	peroxiredoxin activity
KOFIEAFP_00092	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
KOFIEAFP_00093	0.0	-	3.6.4.13	-	L	ko:K03579	-	ko00000,ko01000	ATP-dependent helicase C-terminal
KOFIEAFP_00094	8.06e-216	-	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Cytidylyltransferase family
KOFIEAFP_00095	0.0	-	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	tail specific protease
KOFIEAFP_00096	0.0	-	-	-	E	-	-	-	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KOFIEAFP_00099	1.52e-186	-	3.4.13.22	-	M	ko:K08641	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-ala-D-ala dipeptidase
KOFIEAFP_00100	0.0	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
KOFIEAFP_00101	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
KOFIEAFP_00102	0.0	-	-	-	-	ko:K07403	-	ko00000	-
KOFIEAFP_00103	0.0	-	2.8.4.4	-	J	ko:K14441	-	ko00000,ko01000,ko03009	Uncharacterized protein family UPF0004
KOFIEAFP_00105	0.0	-	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
KOFIEAFP_00106	0.0	pmp21	-	-	T	-	-	-	pathogenesis
KOFIEAFP_00107	1.71e-203	-	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase (PrmA)
KOFIEAFP_00108	1.03e-139	-	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Lumazine binding domain
KOFIEAFP_00109	0.0	-	-	-	P	-	-	-	Putative Na+/H+ antiporter
KOFIEAFP_00110	0.0	-	-	-	G	-	-	-	Polysaccharide deacetylase
KOFIEAFP_00112	3.6e-306	nuoD	1.6.5.3	-	C	ko:K00333	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_00113	2.88e-142	-	1.6.5.3	-	C	ko:K00334	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Thioredoxin-like [2Fe-2S] ferredoxin
KOFIEAFP_00114	0.0	-	1.6.5.3	-	C	ko:K00335	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
KOFIEAFP_00115	0.0	-	1.6.5.3	-	C	ko:K00336	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
KOFIEAFP_00116	2.11e-309	nuoH	1.6.5.3	-	C	ko:K00337	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KOFIEAFP_00117	1.8e-124	nuoI	1.6.5.3	-	C	ko:K00338	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_00118	6.53e-158	-	1.6.5.3	-	C	ko:K00339	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone/plastoquinone oxidoreductase chain 6
KOFIEAFP_00119	6.01e-61	nuoK	1.6.5.3	-	C	ko:K00340	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_00120	0.0	-	1.6.5.3	-	CP	ko:K00341	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
KOFIEAFP_00121	0.0	-	1.6.5.3	-	C	ko:K00342	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Proton-conducting membrane transporter
KOFIEAFP_00122	9.04e-317	nuoN	1.6.5.3	-	C	ko:K00343	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_00123	2.19e-219	-	-	-	E	-	-	-	Domain of unknown function (DUF3472)
KOFIEAFP_00125	2.59e-107	-	-	-	-	-	-	-	-
KOFIEAFP_00126	2.39e-126	-	-	-	S	-	-	-	Pfam:DUF59
KOFIEAFP_00127	0.0	-	5.2.1.8	-	O	ko:K03770	-	ko00000,ko01000,ko03110	PPIC-type PPIASE domain
KOFIEAFP_00128	0.0	-	-	-	E	ko:K03305	-	ko00000	POT family
KOFIEAFP_00129	1.07e-238	-	2.5.1.90	-	H	ko:K02523	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Polyprenyl synthetase
KOFIEAFP_00130	3.23e-289	larC	4.99.1.12	-	S	ko:K09121	-	ko00000,ko01000	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KOFIEAFP_00131	1.97e-190	-	-	-	L	ko:K06864	-	ko00000	tRNA processing
KOFIEAFP_00132	1.47e-171	-	-	-	S	ko:K06898	-	ko00000	AIR carboxylase
KOFIEAFP_00133	0.0	-	-	-	S	-	-	-	Glycosyl hydrolase-like 10
KOFIEAFP_00134	1.74e-157	-	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Iron/manganese superoxide dismutases, alpha-hairpin domain
KOFIEAFP_00135	1.26e-271	-	-	-	IM	-	-	-	Cytidylyltransferase-like
KOFIEAFP_00136	0.0	murJ	-	-	S	ko:K03980	-	ko00000,ko01011,ko02000	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
KOFIEAFP_00137	1.1e-280	-	2.6.1.1	-	E	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
KOFIEAFP_00138	2.83e-110	-	-	-	S	-	-	-	Control of competence regulator ComK, YlbF/YmcA
KOFIEAFP_00139	6e-244	-	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KOFIEAFP_00140	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
KOFIEAFP_00141	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein E, N-terminal domain
KOFIEAFP_00142	4.02e-282	-	-	-	NU	ko:K02653	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein F
KOFIEAFP_00144	3.38e-224	-	-	-	M	-	-	-	Glycosyl transferase family 2
KOFIEAFP_00145	8.2e-209	-	-	-	S	-	-	-	Glycosyltransferase like family 2
KOFIEAFP_00146	1.3e-104	-	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	NDK
KOFIEAFP_00147	4.59e-217	-	-	-	-	-	-	-	-
KOFIEAFP_00148	3.51e-136	-	5.4.99.20	-	J	ko:K06181	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
KOFIEAFP_00149	1.5e-44	-	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	RNA polymerase activity
KOFIEAFP_00150	6.68e-103	smpB	-	-	O	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
KOFIEAFP_00151	4.12e-139	-	-	-	L	-	-	-	RNase_H superfamily
KOFIEAFP_00152	3.86e-112	-	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
KOFIEAFP_00154	4.28e-274	-	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Citrate synthase, C-terminal domain
KOFIEAFP_00155	1.39e-152	-	-	-	O	-	-	-	Glycoprotease family
KOFIEAFP_00156	1.79e-213	-	-	-	-	-	-	-	-
KOFIEAFP_00159	2.89e-123	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	6-O-methylguanine DNA methyltransferase, DNA binding domain
KOFIEAFP_00161	2.26e-288	-	-	-	C	-	-	-	Iron-containing alcohol dehydrogenase
KOFIEAFP_00162	0.0	-	-	-	S	-	-	-	Alpha-2-macroglobulin family
KOFIEAFP_00163	2.51e-66	-	-	-	P	-	-	-	T5orf172
KOFIEAFP_00164	9.54e-261	-	-	-	L	-	-	-	Type III restriction enzyme res subunit
KOFIEAFP_00165	2.29e-278	yeeA	-	-	V	-	-	-	DNA modification
KOFIEAFP_00166	4.03e-69	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
KOFIEAFP_00167	3.07e-211	MA20_36650	-	-	EG	-	-	-	spore germination
KOFIEAFP_00168	0.0	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
KOFIEAFP_00169	0.0	-	-	-	L	-	-	-	UvrD/REP helicase N-terminal domain
KOFIEAFP_00172	0.0	-	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	Peptidase family M50
KOFIEAFP_00173	6.39e-80	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KOFIEAFP_00174	2.91e-38	-	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L35
KOFIEAFP_00175	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
KOFIEAFP_00179	6.25e-07	-	-	-	KLT	-	-	-	Lanthionine synthetase C-like protein
KOFIEAFP_00180	9.05e-44	-	-	-	S	-	-	-	von Willebrand factor type A domain
KOFIEAFP_00181	1.98e-19	-	2.7.11.1	-	KLT	ko:K12132	-	ko00000,ko01000,ko01001	serine threonine protein kinase
KOFIEAFP_00186	8.12e-25	-	-	-	-	-	-	-	-
KOFIEAFP_00188	2.23e-61	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
KOFIEAFP_00189	6.61e-180	-	2.1.1.37	-	H	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	C-5 cytosine-specific DNA methylase
KOFIEAFP_00190	6.8e-208	-	-	-	T	-	-	-	Histidine kinase
KOFIEAFP_00191	5.21e-50	-	-	-	KT	-	-	-	RESPONSE REGULATOR receiver
KOFIEAFP_00192	9.52e-58	vsr	-	-	L	ko:K07458	-	ko00000,ko01000,ko03400	May nick specific sequences that contain T G mispairs resulting from m5C-deamination
KOFIEAFP_00193	6.34e-46	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.96
KOFIEAFP_00198	1.65e-66	ps305	-	-	S	-	-	-	Protein of unknown function (Hypoth_ymh)
KOFIEAFP_00199	1.31e-168	-	-	-	S	-	-	-	Pfam:HipA_N
KOFIEAFP_00200	8.52e-37	-	-	-	K	-	-	-	sequence-specific DNA binding
KOFIEAFP_00202	3.28e-05	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
KOFIEAFP_00203	7.13e-276	-	-	-	G	-	-	-	Major Facilitator Superfamily
KOFIEAFP_00204	5.49e-85	nuoA	1.6.5.3	-	C	ko:K00330	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_00206	3.79e-195	supH	-	-	Q	-	-	-	phosphatase activity
KOFIEAFP_00207	0.0	legA	3.5.1.2	-	G	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	response to abiotic stimulus
KOFIEAFP_00208	0.0	-	-	-	EG	-	-	-	BNR repeat-like domain
KOFIEAFP_00209	1.1e-187	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
KOFIEAFP_00210	8.08e-189	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
KOFIEAFP_00211	0.0	-	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
KOFIEAFP_00212	2.72e-191	-	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	4Fe-4S single cluster domain
KOFIEAFP_00213	0.0	-	2.3.1.241	-	M	ko:K02517	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Glycosyltransferase family 9 (heptosyltransferase)
KOFIEAFP_00214	1.08e-63	-	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L36
KOFIEAFP_00215	4.15e-287	-	2.3.1.31	-	E	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko01000	alpha/beta hydrolase fold
KOFIEAFP_00218	3.97e-07	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
KOFIEAFP_00219	1.26e-13	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
KOFIEAFP_00221	6.2e-89	-	-	-	O	-	-	-	response to oxidative stress
KOFIEAFP_00222	0.0	-	-	-	T	-	-	-	pathogenesis
KOFIEAFP_00224	1.57e-187	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
KOFIEAFP_00225	5.12e-287	-	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KOFIEAFP_00226	1.7e-154	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	N-(5'phosphoribosyl)anthranilate (PRA) isomerase
KOFIEAFP_00227	1.95e-176	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
KOFIEAFP_00228	0.0	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KOFIEAFP_00229	0.0	-	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Anthranilate synthase component I, N terminal region
KOFIEAFP_00233	0.0	hppA	3.6.1.1	-	C	ko:K15987	ko00190,map00190	ko00000,ko00001,ko01000	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane
KOFIEAFP_00234	4.06e-244	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
KOFIEAFP_00235	8.42e-184	-	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
KOFIEAFP_00236	2.55e-247	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
KOFIEAFP_00237	1.83e-188	-	-	-	-	-	-	-	-
KOFIEAFP_00238	3.26e-173	-	-	-	NU	ko:K02457,ko:K08084	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	protein transport across the cell outer membrane
KOFIEAFP_00239	2.85e-243	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
KOFIEAFP_00240	6.91e-165	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70 region 2
KOFIEAFP_00241	0.0	-	-	-	KT	-	-	-	Sigma factor PP2C-like phosphatases
KOFIEAFP_00242	8.03e-295	-	-	-	EGP	-	-	-	Major facilitator Superfamily
KOFIEAFP_00243	0.0	-	-	-	M	-	-	-	Peptidase M60-like family
KOFIEAFP_00244	1.8e-215	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
KOFIEAFP_00245	1.66e-307	-	-	-	M	-	-	-	OmpA family
KOFIEAFP_00246	3.63e-270	-	-	-	E	-	-	-	serine-type peptidase activity
KOFIEAFP_00247	3.06e-286	-	-	-	S	ko:K11720	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
KOFIEAFP_00248	4.01e-170	-	-	-	S	-	-	-	HAD-hyrolase-like
KOFIEAFP_00250	1.54e-217	-	2.3.1.39	-	I	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Acyl transferase domain
KOFIEAFP_00251	4.19e-87	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
KOFIEAFP_00252	1.64e-261	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KOFIEAFP_00253	1.61e-256	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Possible lysine decarboxylase
KOFIEAFP_00254	3.26e-278	-	3.4.23.43	-	NOU	ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type IV leader peptidase family
KOFIEAFP_00256	0.0	secD	-	-	U	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KOFIEAFP_00257	4.82e-227	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
KOFIEAFP_00258	7.74e-174	-	-	-	T	-	-	-	Outer membrane lipoprotein-sorting protein
KOFIEAFP_00259	3.17e-166	-	-	-	S	ko:K05810	-	ko00000,ko01000	Multi-copper polyphenol oxidoreductase laccase
KOFIEAFP_00260	1.12e-217	-	-	-	-	-	-	-	-
KOFIEAFP_00262	5.46e-170	-	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Type I 3-dehydroquinase
KOFIEAFP_00263	4.4e-217	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
KOFIEAFP_00266	7.58e-209	-	-	-	J	ko:K01894	-	ko00000,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), catalytic domain
KOFIEAFP_00267	0.0	-	-	-	P	-	-	-	Citrate transporter
KOFIEAFP_00268	1.79e-144	-	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase homologues.
KOFIEAFP_00269	3.01e-195	-	-	-	S	-	-	-	Domain of unknown function (DUF1732)
KOFIEAFP_00270	0.0	-	2.6.1.66	-	E	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_00273	1.29e-236	-	-	-	CO	-	-	-	Protein of unknown function, DUF255
KOFIEAFP_00274	6.18e-173	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	transporter
KOFIEAFP_00275	4.82e-220	-	-	-	L	-	-	-	Membrane
KOFIEAFP_00276	3.82e-255	-	2.7.1.11, 2.7.1.90	-	G	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Phosphofructokinase
KOFIEAFP_00277	3.37e-224	-	-	-	M	-	-	-	D-alanyl-D-alanine carboxypeptidase
KOFIEAFP_00280	4.4e-212	-	1.1.1.262	-	H	ko:K00097	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal phosphate biosynthetic protein PdxA
KOFIEAFP_00281	1.56e-60	-	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S6
KOFIEAFP_00282	1.53e-146	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KOFIEAFP_00283	1.48e-141	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Imidazoleglycerol-phosphate dehydratase
KOFIEAFP_00285	1.24e-131	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KOFIEAFP_00286	4.58e-220	prs	2.7.6.1	-	EF	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KOFIEAFP_00287	5.89e-230	-	-	-	C	-	-	-	Transmembrane exosortase (Exosortase_EpsH)
KOFIEAFP_00288	1.51e-174	-	-	-	S	-	-	-	Protein of unknown function (DUF3485)
KOFIEAFP_00289	5.95e-167	pks6	-	-	Q	-	-	-	amino acid activation for nonribosomal peptide biosynthetic process
KOFIEAFP_00290	6.29e-151	-	-	-	-	-	-	-	-
KOFIEAFP_00291	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
KOFIEAFP_00292	0.0	-	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Peptidase S24-like
KOFIEAFP_00293	1.02e-228	-	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Squalene/phytoene synthase
KOFIEAFP_00294	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
KOFIEAFP_00295	2.96e-242	-	3.1.3.18	-	F	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
KOFIEAFP_00296	3.68e-173	-	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
KOFIEAFP_00297	1.2e-262	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
KOFIEAFP_00298	4.23e-117	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KOFIEAFP_00299	3.65e-60	-	-	-	S	ko:K09131	-	ko00000	DUF167
KOFIEAFP_00300	4.5e-176	-	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidine biosynthesis protein
KOFIEAFP_00302	7.06e-249	-	-	-	-	-	-	-	-
KOFIEAFP_00303	1.14e-126	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
KOFIEAFP_00304	4e-147	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
KOFIEAFP_00305	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	ATPases associated with a variety of cellular activities
KOFIEAFP_00307	7.7e-31	-	-	-	S	ko:K07126	-	ko00000	Sel1-like repeats.
KOFIEAFP_00308	5.86e-110	-	-	-	S	-	-	-	Putative zinc- or iron-chelating domain
KOFIEAFP_00309	3.75e-305	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KOFIEAFP_00310	5.85e-253	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Semialdehyde dehydrogenase, NAD binding domain
KOFIEAFP_00312	0.0	-	-	-	ET	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
KOFIEAFP_00313	8.78e-167	-	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
KOFIEAFP_00314	4.37e-124	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	adenylate kinase activity
KOFIEAFP_00315	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00316	3.17e-171	-	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
KOFIEAFP_00317	1.07e-192	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
KOFIEAFP_00318	8.43e-155	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
KOFIEAFP_00319	0.0	-	-	-	M	ko:K04744	-	ko00000,ko02000	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KOFIEAFP_00320	0.0	-	-	-	M	-	-	-	NPCBM/NEW2 domain
KOFIEAFP_00321	0.0	-	-	-	G	-	-	-	Glycogen debranching enzyme
KOFIEAFP_00322	7.43e-231	-	1.1.1.37	-	C	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible oxidation of malate to oxaloacetate
KOFIEAFP_00323	0.0	-	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	UDP binding domain
KOFIEAFP_00327	1.55e-99	-	-	-	MP	-	-	-	regulation of cell-substrate adhesion
KOFIEAFP_00331	2.59e-75	-	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
KOFIEAFP_00332	4.05e-242	tilS	6.3.4.19	-	D	ko:K04075	-	ko00000,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
KOFIEAFP_00333	1.4e-259	-	2.3.1.8	-	C	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphate acetyl/butaryl transferase
KOFIEAFP_00334	5.56e-214	-	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	PHP domain
KOFIEAFP_00336	2.11e-254	-	-	-	S	-	-	-	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
KOFIEAFP_00337	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
KOFIEAFP_00338	2.46e-291	-	-	-	-	-	-	-	-
KOFIEAFP_00339	0.0	-	-	-	L	-	-	-	TRCF
KOFIEAFP_00340	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
KOFIEAFP_00341	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	myo-inosose-2 dehydratase activity
KOFIEAFP_00342	3.82e-236	-	-	-	-	-	-	-	-
KOFIEAFP_00343	5.52e-284	pgk	2.7.2.3	-	G	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglycerate kinase
KOFIEAFP_00344	1.67e-249	-	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
KOFIEAFP_00345	1.09e-148	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
KOFIEAFP_00347	2.63e-142	-	-	-	M	-	-	-	Polysaccharide biosynthesis/export protein
KOFIEAFP_00348	0.0	-	-	-	D	-	-	-	Chain length determinant protein
KOFIEAFP_00349	3.27e-297	-	-	-	-	-	-	-	-
KOFIEAFP_00353	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
KOFIEAFP_00354	7.54e-99	-	-	-	S	-	-	-	peptidase
KOFIEAFP_00355	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
KOFIEAFP_00356	2.2e-61	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KOFIEAFP_00357	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	MreB/Mbl protein
KOFIEAFP_00358	0.0	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
KOFIEAFP_00359	4.65e-279	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
KOFIEAFP_00360	1.71e-239	-	-	-	O	ko:K04655	-	ko00000	AIR synthase related protein, N-terminal domain
KOFIEAFP_00361	7.79e-262	-	-	-	O	ko:K04654	-	ko00000	Hydrogenase formation hypA family
KOFIEAFP_00362	2.74e-50	-	-	-	O	ko:K04653	-	ko00000	HupF/HypC family
KOFIEAFP_00363	0.0	-	-	-	O	ko:K04656	-	ko00000	HypF finger
KOFIEAFP_00364	1.44e-175	hypB	-	-	KO	ko:K04652	-	ko00000,ko03110	CobW/HypB/UreG, nucleotide-binding domain
KOFIEAFP_00365	3e-310	-	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Histidyl-tRNA synthetase
KOFIEAFP_00366	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KOFIEAFP_00370	9.87e-263	-	2.3.1.47	-	H	ko:K00652	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_00371	4.02e-282	-	-	-	IQ	-	-	-	Beta-ketoacyl synthase, C-terminal domain
KOFIEAFP_00372	0.0	-	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	thiolester hydrolase activity
KOFIEAFP_00373	4.38e-286	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
KOFIEAFP_00374	1.34e-147	-	-	-	IQ	-	-	-	RmlD substrate binding domain
KOFIEAFP_00375	0.0	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GcpE protein
KOFIEAFP_00376	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
KOFIEAFP_00377	8.75e-198	-	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KOFIEAFP_00378	4.03e-120	-	-	-	-	-	-	-	-
KOFIEAFP_00379	3.85e-194	-	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	CDP-alcohol phosphatidyltransferase
KOFIEAFP_00380	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KOFIEAFP_00381	5.59e-227	-	-	-	M	ko:K01993	-	ko00000	HlyD family secretion protein
KOFIEAFP_00382	0.0	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00383	1.03e-243	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
KOFIEAFP_00384	4.19e-244	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
KOFIEAFP_00387	6.7e-301	nupG	-	-	G	ko:K03289,ko:K03301,ko:K08218,ko:K11537	ko01501,map01501	ko00000,ko00001,ko00002,ko02000	Major facilitator Superfamily
KOFIEAFP_00388	5.91e-259	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KOFIEAFP_00389	4.86e-110	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07305,ko:K12267	-	ko00000,ko01000	peptide-methionine (R)-S-oxide reductase activity
KOFIEAFP_00390	3.9e-306	-	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
KOFIEAFP_00392	3.08e-146	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KOFIEAFP_00393	2.37e-46	-	-	-	J	-	-	-	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KOFIEAFP_00394	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00395	0.0	-	-	-	S	-	-	-	Sodium:neurotransmitter symporter family
KOFIEAFP_00396	3.6e-152	-	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
KOFIEAFP_00397	1.45e-208	-	-	-	M	-	-	-	Mechanosensitive ion channel
KOFIEAFP_00398	4.62e-165	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Amino acid kinase family
KOFIEAFP_00399	2.53e-120	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
KOFIEAFP_00400	9.17e-70	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
KOFIEAFP_00401	1.7e-101	-	-	-	K	-	-	-	DNA-binding transcription factor activity
KOFIEAFP_00402	3.03e-231	-	-	-	J	-	-	-	Belongs to the universal ribosomal protein uS2 family
KOFIEAFP_00403	3.54e-229	-	-	-	L	-	-	-	Elongator protein 3, MiaB family, Radical SAM
KOFIEAFP_00404	4.72e-153	-	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
KOFIEAFP_00405	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
KOFIEAFP_00407	7.65e-101	-	-	-	M	ko:K06077	-	ko00000	Glycine zipper 2TM domain
KOFIEAFP_00408	6.15e-234	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Converts alpha-aldose to the beta-anomer
KOFIEAFP_00409	2.57e-140	-	-	-	P	ko:K02039	-	ko00000	PhoU domain
KOFIEAFP_00410	1.29e-185	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
KOFIEAFP_00411	1.51e-221	-	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	PBP superfamily domain
KOFIEAFP_00412	0.0	pstC	-	-	P	ko:K02037,ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_00413	0.0	-	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_00414	4.85e-185	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
KOFIEAFP_00415	1.33e-151	phoU	-	-	P	ko:K02039	-	ko00000	negative regulation of phosphate transmembrane transport
KOFIEAFP_00417	6.9e-282	-	-	-	J	-	-	-	PFAM Endoribonuclease L-PSP
KOFIEAFP_00418	0.0	-	-	-	C	-	-	-	cytochrome C peroxidase
KOFIEAFP_00419	0.0	-	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
KOFIEAFP_00420	1.13e-12	-	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	Arginase family
KOFIEAFP_00421	7.27e-290	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase family U32
KOFIEAFP_00422	2.66e-147	-	-	-	C	-	-	-	lactate oxidation
KOFIEAFP_00423	0.0	-	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	DNA Topoisomerase IV
KOFIEAFP_00424	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KOFIEAFP_00425	0.0	-	-	-	CO	-	-	-	Thioredoxin-like
KOFIEAFP_00430	1.37e-115	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KOFIEAFP_00431	0.0	-	-	-	S	ko:K07037	-	ko00000	7TM receptor with intracellular HD hydrolase
KOFIEAFP_00432	1.22e-246	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
KOFIEAFP_00433	2.73e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
KOFIEAFP_00434	2.03e-116	-	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
KOFIEAFP_00435	6.98e-80	-	-	-	FG	ko:K02503	-	ko00000,ko04147	HIT domain
KOFIEAFP_00436	8.48e-242	-	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
KOFIEAFP_00437	1.33e-129	aroK	2.7.1.71	-	E	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KOFIEAFP_00438	9.56e-51	-	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S16
KOFIEAFP_00441	1.31e-214	-	-	-	L	ko:K03733	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
KOFIEAFP_00442	4.58e-186	-	-	-	DTZ	-	-	-	EF-hand, calcium binding motif
KOFIEAFP_00443	5.64e-66	-	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit
KOFIEAFP_00444	1.39e-282	tgt	2.4.2.29	-	J	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
KOFIEAFP_00445	1.42e-149	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Putative methyltransferase
KOFIEAFP_00446	4.32e-174	-	-	-	F	-	-	-	NUDIX domain
KOFIEAFP_00447	2.43e-126	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
KOFIEAFP_00448	2.33e-205	-	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
KOFIEAFP_00449	1.9e-62	-	-	-	L	-	-	-	bacterial (prokaryotic) histone like domain
KOFIEAFP_00455	1.43e-142	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
KOFIEAFP_00456	5.23e-171	-	2.5.1.39	-	H	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KOFIEAFP_00457	3.33e-254	-	5.2.1.8	-	O	ko:K03771	-	ko00000,ko01000,ko03110	SurA N-terminal domain
KOFIEAFP_00458	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Domain of unknown function (DUF4982)
KOFIEAFP_00459	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
KOFIEAFP_00460	3.74e-204	-	-	-	-	-	-	-	-
KOFIEAFP_00461	6.79e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KOFIEAFP_00462	2.19e-56	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KOFIEAFP_00463	2.36e-34	-	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L29 protein
KOFIEAFP_00464	3.42e-97	-	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KOFIEAFP_00465	4.27e-155	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KOFIEAFP_00466	4.97e-70	-	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
KOFIEAFP_00467	4.05e-152	-	-	-	-	-	-	-	-
KOFIEAFP_00468	1.05e-58	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KOFIEAFP_00469	1.85e-203	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KOFIEAFP_00470	8.72e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
KOFIEAFP_00471	9.43e-132	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L4/L1 family
KOFIEAFP_00472	1.35e-149	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KOFIEAFP_00473	3.67e-65	-	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S10p/S20e
KOFIEAFP_00474	0.0	-	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KOFIEAFP_00475	2.91e-104	-	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S7p/S5e
KOFIEAFP_00476	4.16e-85	-	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S12/S23
KOFIEAFP_00477	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	BPG-independent PGAM N-terminus (iPGM_N)
KOFIEAFP_00478	3.37e-97	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase superfamily
KOFIEAFP_00479	7.39e-274	-	-	-	T	-	-	-	PAS domain
KOFIEAFP_00480	0.0	-	-	-	T	-	-	-	Bacterial regulatory protein, Fis family
KOFIEAFP_00481	0.0	-	-	-	O	-	-	-	C-terminal four TMM region of protein-O-mannosyltransferase
KOFIEAFP_00482	3.08e-52	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease VII activity
KOFIEAFP_00483	0.0	dxs	2.2.1.7	-	HI	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KOFIEAFP_00484	3.99e-183	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00485	1.1e-125	-	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Recombination protein O N terminal
KOFIEAFP_00486	9.67e-251	-	-	-	S	ko:K07091	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
KOFIEAFP_00487	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal
KOFIEAFP_00488	1.24e-230	-	-	-	EP	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
KOFIEAFP_00489	7.54e-156	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	Chloramphenicol acetyltransferase
KOFIEAFP_00491	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
KOFIEAFP_00492	5.19e-170	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00493	0.0	-	-	-	P	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
KOFIEAFP_00494	1.3e-207	-	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydrogenase
KOFIEAFP_00496	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
KOFIEAFP_00497	3.42e-111	-	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	Cytidine and deoxycytidylate deaminase zinc-binding region
KOFIEAFP_00499	1.86e-94	-	-	-	O	-	-	-	OsmC-like protein
KOFIEAFP_00500	0.0	-	-	-	CO	-	-	-	Disulphide bond corrector protein DsbC
KOFIEAFP_00501	3.99e-176	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
KOFIEAFP_00502	2.75e-142	-	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Exonuclease
KOFIEAFP_00503	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KOFIEAFP_00504	4.69e-79	rsfS	-	-	S	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
KOFIEAFP_00505	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KOFIEAFP_00507	1.29e-257	-	-	-	S	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
KOFIEAFP_00508	4.36e-200	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Enoyl-CoA hydratase/isomerase
KOFIEAFP_00511	2.63e-302	-	-	-	MU	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	efflux transmembrane transporter activity
KOFIEAFP_00516	9.85e-147	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
KOFIEAFP_00519	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
KOFIEAFP_00520	8.38e-98	-	-	-	-	-	-	-	-
KOFIEAFP_00521	3.14e-192	-	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
KOFIEAFP_00522	0.0	-	-	-	S	-	-	-	Fungal chitosanase of glycosyl hydrolase group 75
KOFIEAFP_00523	2.77e-220	-	2.5.1.21	-	I	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01006	Squalene/phytoene synthase
KOFIEAFP_00524	0.0	-	-	-	KT	ko:K02584	ko02020,map02020	ko00000,ko00001,ko03000	Bacterial regulatory protein, Fis family
KOFIEAFP_00525	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
KOFIEAFP_00527	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_00529	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00530	0.0	-	4.1.1.15	-	E	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase conserved domain
KOFIEAFP_00531	2.12e-141	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
KOFIEAFP_00532	0.0	-	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase alpha chain like domain
KOFIEAFP_00533	4.25e-238	pyrD	1.3.5.2	-	F	ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroorotate dehydrogenase
KOFIEAFP_00534	4.52e-154	-	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Thiamine monophosphate synthase
KOFIEAFP_00535	3.69e-158	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
KOFIEAFP_00536	1.39e-165	-	-	-	CO	-	-	-	Thioredoxin-like
KOFIEAFP_00537	0.0	-	-	-	C	-	-	-	Cytochrome c554 and c-prime
KOFIEAFP_00538	1.09e-307	-	-	-	S	-	-	-	PFAM CBS domain containing protein
KOFIEAFP_00539	9.05e-313	tlyC	-	-	S	ko:K03699	-	ko00000,ko02042	PFAM CBS domain containing protein
KOFIEAFP_00540	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
KOFIEAFP_00541	3.01e-49	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal_S15
KOFIEAFP_00542	2.32e-151	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
KOFIEAFP_00543	1.7e-178	-	-	-	D	ko:K19234,ko:K19236	ko01503,map01503	ko00000,ko00001,ko01002,ko01011	ErfK ybiS ycfS ynhG family protein
KOFIEAFP_00544	0.0	-	-	-	S	-	-	-	Terminase
KOFIEAFP_00547	3.07e-200	-	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
KOFIEAFP_00548	8.59e-144	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KOFIEAFP_00549	9.86e-168	-	-	-	M	-	-	-	Peptidase family M23
KOFIEAFP_00550	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	PFAM coagulation factor 5 8 type domain protein
KOFIEAFP_00552	1.33e-174	-	-	-	NU	-	-	-	Prepilin-type N-terminal cleavage methylation domain
KOFIEAFP_00554	1.8e-181	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KOFIEAFP_00555	0.0	-	-	-	S	-	-	-	Type I phosphodiesterase / nucleotide pyrophosphatase
KOFIEAFP_00556	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
KOFIEAFP_00557	1.7e-153	-	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	AAA domain
KOFIEAFP_00559	8.41e-202	-	-	-	S	-	-	-	DisA bacterial checkpoint controller nucleotide-binding
KOFIEAFP_00560	5.14e-143	-	-	-	-	-	-	-	-
KOFIEAFP_00561	6.38e-151	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00562	1.39e-195	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KOFIEAFP_00563	1.48e-120	-	-	-	M	ko:K06142	-	ko00000	Outer membrane protein (OmpH-like)
KOFIEAFP_00564	5.68e-188	lpxD	2.3.1.191	-	M	ko:K02536	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KOFIEAFP_00565	1.4e-195	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_00566	1.34e-188	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00567	1.01e-249	-	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	NMT1/THI5 like
KOFIEAFP_00569	7.06e-222	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
KOFIEAFP_00570	6.23e-118	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Polynucleotide kinase 3 phosphatase
KOFIEAFP_00571	6.51e-128	-	5.3.1.28	-	G	ko:K03271	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
KOFIEAFP_00572	0.0	-	2.7.1.167, 2.7.7.70	-	M	ko:K03272	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	pfkB family carbohydrate kinase
KOFIEAFP_00573	1.06e-44	-	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S21
KOFIEAFP_00574	1.05e-311	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
KOFIEAFP_00575	1.63e-257	-	-	-	S	-	-	-	ankyrin repeats
KOFIEAFP_00576	0.0	-	-	-	EGP	-	-	-	Sugar (and other) transporter
KOFIEAFP_00577	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00578	0.0	glnS	6.1.1.18	-	J	ko:K01886	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), anti-codon binding domain
KOFIEAFP_00579	9.59e-288	-	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase II
KOFIEAFP_00580	7.32e-105	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
KOFIEAFP_00581	1.15e-205	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KOFIEAFP_00582	1.1e-197	-	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SRP54-type protein, GTPase domain
KOFIEAFP_00583	1.07e-261	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Elongator protein 3, MiaB family, Radical SAM
KOFIEAFP_00584	0.0	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
KOFIEAFP_00585	1.31e-181	-	-	-	U	ko:K20276	ko02024,map02024	ko00000,ko00001	domain, Protein
KOFIEAFP_00586	6.87e-153	-	-	-	O	-	-	-	methyltransferase activity
KOFIEAFP_00587	5.92e-289	-	3.5.1.42	-	S	ko:K03742	ko00760,map00760	ko00000,ko00001,ko01000	Competence-damaged protein
KOFIEAFP_00588	0.0	-	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Pyruvate kinase, barrel domain
KOFIEAFP_00589	1.07e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
KOFIEAFP_00593	4.89e-192	-	-	-	E	-	-	-	haloacid dehalogenase-like hydrolase
KOFIEAFP_00594	7.24e-141	-	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S4/S9 N-terminal domain
KOFIEAFP_00595	2.11e-121	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KOFIEAFP_00596	1.11e-79	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KOFIEAFP_00597	3.9e-270	-	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Domain of unknown function (DUF1730)
KOFIEAFP_00598	1.18e-224	-	-	-	M	ko:K07276	-	ko00000	Mitochondrial fission ELM1
KOFIEAFP_00599	6.01e-269	-	-	-	M	-	-	-	Glycosyl transferase 4-like
KOFIEAFP_00600	1.21e-266	-	-	-	LU	ko:K04096	-	ko00000	DNA recombination-mediator protein A
KOFIEAFP_00601	1.42e-217	-	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
KOFIEAFP_00602	5.5e-262	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
KOFIEAFP_00603	2.44e-268	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Aminomethyltransferase folate-binding domain
KOFIEAFP_00604	6.67e-86	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
KOFIEAFP_00605	0.0	gcvP	1.4.4.2	-	E	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KOFIEAFP_00607	2.16e-150	-	-	-	L	-	-	-	Membrane
KOFIEAFP_00608	0.0	-	-	-	P	ko:K01138	-	ko00000,ko01000	PA14 domain
KOFIEAFP_00609	0.0	-	3.6.4.13	-	L	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DbpA RNA binding domain
KOFIEAFP_00610	1.07e-176	-	-	-	-	-	-	-	-
KOFIEAFP_00611	0.0	-	3.1.1.53	-	E	ko:K05970	-	ko00000,ko01000	Carbohydrate esterase, sialic acid-specific acetylesterase
KOFIEAFP_00612	1.72e-243	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
KOFIEAFP_00613	1.84e-105	-	-	-	S	ko:K15977	-	ko00000	DoxX
KOFIEAFP_00614	4.07e-246	-	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR synthase related protein, N-terminal domain
KOFIEAFP_00615	0.0	-	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KOFIEAFP_00616	1.26e-139	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
KOFIEAFP_00618	2.34e-208	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
KOFIEAFP_00619	1.31e-81	-	-	-	DJ	-	-	-	Addiction module toxin, RelE StbE family
KOFIEAFP_00620	8.37e-126	-	4.1.1.36	-	H	ko:K01598	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Flavoprotein
KOFIEAFP_00622	2.31e-259	-	-	-	M	-	-	-	Peptidase family M23
KOFIEAFP_00623	0.0	-	-	-	S	-	-	-	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KOFIEAFP_00624	0.0	-	-	-	L	-	-	-	Polyphosphate kinase 2 (PPK2)
KOFIEAFP_00625	2.48e-173	-	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
KOFIEAFP_00626	1.6e-103	-	-	-	K	ko:K03826	-	ko00000,ko01000	acetyltransferase
KOFIEAFP_00627	3.95e-278	-	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class-V
KOFIEAFP_00628	9.69e-157	-	6.3.2.5	-	H	ko:K21977	ko00770,map00770	ko00000,ko00001,ko00002,ko01000	DNA / pantothenate metabolism flavoprotein
KOFIEAFP_00629	2.37e-272	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
KOFIEAFP_00630	2.31e-233	-	-	-	S	-	-	-	Aspartyl protease
KOFIEAFP_00631	9.66e-309	-	2.4.99.12, 2.4.99.13, 2.4.99.14, 2.4.99.15	GT30	M	ko:K02527	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)
KOFIEAFP_00632	3.35e-131	-	-	-	L	-	-	-	Conserved hypothetical protein 95
KOFIEAFP_00633	1.36e-175	-	-	-	-	-	-	-	-
KOFIEAFP_00635	1.49e-224	-	-	-	S	-	-	-	Polyphosphate kinase 2 (PPK2)
KOFIEAFP_00636	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00637	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
KOFIEAFP_00639	6.18e-199	-	-	-	S	ko:K06889	-	ko00000	alpha beta
KOFIEAFP_00640	5.76e-107	-	-	-	S	ko:K06925	-	ko00000,ko03016	Threonylcarbamoyl adenosine biosynthesis protein TsaE
KOFIEAFP_00641	5.31e-64	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal prokaryotic L21 protein
KOFIEAFP_00642	2.14e-57	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L27 protein
KOFIEAFP_00643	6.78e-100	-	-	-	P	ko:K09825	-	ko00000,ko03000	Ferric uptake regulator family
KOFIEAFP_00644	1.02e-178	-	-	-	O	ko:K09013	-	ko00000,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00645	0.0	-	-	-	O	ko:K09014	-	ko00000	Uncharacterized protein family (UPF0051)
KOFIEAFP_00646	2.9e-293	-	-	-	O	ko:K09015	-	ko00000	Uncharacterized protein family (UPF0051)
KOFIEAFP_00647	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
KOFIEAFP_00648	0.0	-	-	-	P	-	-	-	Sulfatase
KOFIEAFP_00649	1.77e-234	-	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Biotin and Thiamin Synthesis associated domain
KOFIEAFP_00650	0.0	-	2.6.1.62	-	H	ko:K00833	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
KOFIEAFP_00651	6.28e-136	-	-	-	F	-	-	-	Bacteriocin-protection, YdeI or OmpD-Associated
KOFIEAFP_00654	3.2e-76	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
KOFIEAFP_00655	1.08e-73	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
KOFIEAFP_00656	5.15e-218	-	-	-	M	-	-	-	Glycosyl transferase family 2
KOFIEAFP_00657	2.09e-115	flmH	2.3.1.57	-	J	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOFIEAFP_00658	1.96e-287	-	2.6.1.59	-	M	ko:K02805	-	ko00000,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
KOFIEAFP_00659	1.89e-278	-	-	-	S	-	-	-	COGs COG4299 conserved
KOFIEAFP_00660	2.34e-123	sprT	-	-	K	-	-	-	SprT-like family
KOFIEAFP_00661	3.38e-140	-	-	-	-	-	-	-	-
KOFIEAFP_00662	1.24e-90	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
KOFIEAFP_00663	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KOFIEAFP_00664	4.5e-201	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KOFIEAFP_00665	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KOFIEAFP_00666	6.46e-86	-	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase delta (OSCP) subunit
KOFIEAFP_00667	4.38e-78	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase B/B' CF(0)
KOFIEAFP_00668	1.65e-11	-	-	-	S	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	PFAM H transporting two-sector ATPase C subunit
KOFIEAFP_00669	6.27e-219	-	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	ATP synthase A chain
KOFIEAFP_00670	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00671	0.0	-	3.4.16.4	-	M	ko:K05515	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein dimerisation domain
KOFIEAFP_00672	3.16e-127	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_00673	3.11e-271	-	-	-	S	-	-	-	COGs COG4299 conserved
KOFIEAFP_00674	0.0	-	-	-	G	-	-	-	Raffinose synthase or seed imbibition protein Sip1
KOFIEAFP_00676	1.67e-217	-	-	-	I	-	-	-	alpha/beta hydrolase fold
KOFIEAFP_00677	1.01e-223	-	-	-	-	-	-	-	-
KOFIEAFP_00678	3.67e-126	-	-	-	U	-	-	-	response to pH
KOFIEAFP_00679	9.39e-183	-	-	-	H	-	-	-	ThiF family
KOFIEAFP_00680	1.18e-224	-	5.3.1.13	-	M	ko:K06041	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
KOFIEAFP_00681	9.48e-193	-	-	-	-	-	-	-	-
KOFIEAFP_00682	7.92e-292	-	4.2.1.129, 5.4.99.17	-	I	ko:K06045	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
KOFIEAFP_00683	1.06e-109	-	-	-	S	ko:K15977	-	ko00000	DoxX
KOFIEAFP_00684	1.34e-201	-	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase, N-terminal
KOFIEAFP_00685	5.79e-306	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KOFIEAFP_00686	1.71e-179	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KOFIEAFP_00687	0.0	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KOFIEAFP_00688	0.0	-	-	-	K	-	-	-	Transcription elongation factor, N-terminal
KOFIEAFP_00689	1.89e-166	-	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	SAICAR synthetase
KOFIEAFP_00690	5.55e-116	-	-	-	-	-	-	-	-
KOFIEAFP_00691	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
KOFIEAFP_00692	6.16e-176	-	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	CobB/CobQ-like glutamine amidotransferase domain
KOFIEAFP_00694	2.24e-263	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
KOFIEAFP_00696	0.0	lacZ_17	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
KOFIEAFP_00697	5.06e-236	-	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Actin
KOFIEAFP_00698	0.0	-	-	-	J	ko:K08301	-	ko00000,ko01000,ko03009,ko03019	Ribonuclease E/G family
KOFIEAFP_00699	8.99e-277	-	-	-	K	-	-	-	sequence-specific DNA binding
KOFIEAFP_00700	3.31e-196	-	-	-	-	-	-	-	-
KOFIEAFP_00701	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00702	4.52e-101	exbD2	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
KOFIEAFP_00703	1.65e-113	aglS	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
KOFIEAFP_00704	9.91e-171	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
KOFIEAFP_00705	1.45e-149	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KOFIEAFP_00706	3.56e-147	-	-	-	S	-	-	-	3D domain
KOFIEAFP_00707	1.38e-228	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
KOFIEAFP_00708	1.6e-175	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
KOFIEAFP_00710	4.83e-82	-	-	-	L	ko:K07460	-	ko00000	Uncharacterised protein family UPF0102
KOFIEAFP_00711	2.51e-151	-	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
KOFIEAFP_00712	1.94e-309	-	-	-	S	-	-	-	PFAM CBS domain containing protein
KOFIEAFP_00713	8.43e-59	-	-	-	S	-	-	-	Zinc ribbon domain
KOFIEAFP_00714	2.79e-54	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KOFIEAFP_00716	2.9e-316	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Arginosuccinate synthase
KOFIEAFP_00717	2.35e-114	-	3.1.6.8	-	P	ko:K01134	ko00600,ko04142,map00600,map04142	ko00000,ko00001,ko01000	COG3119 Arylsulfatase A
KOFIEAFP_00718	1.11e-299	-	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	16S rRNA methyltransferase RsmB/F
KOFIEAFP_00719	4.82e-178	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
KOFIEAFP_00720	1.29e-164	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
KOFIEAFP_00721	1.3e-143	-	-	-	-	-	-	-	-
KOFIEAFP_00722	0.0	-	3.1.6.1	-	P	ko:K01130	ko00140,ko00600,map00140,map00600	ko00000,ko00001,ko01000	Sulfatase
KOFIEAFP_00725	1.67e-100	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
KOFIEAFP_00726	8.39e-181	-	-	-	S	-	-	-	competence protein
KOFIEAFP_00727	2.92e-70	-	-	-	-	-	-	-	-
KOFIEAFP_00728	4.15e-191	-	3.6.1.66	-	S	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	MazG nucleotide pyrophosphohydrolase domain
KOFIEAFP_00729	3.68e-75	-	-	-	-	-	-	-	-
KOFIEAFP_00730	1.3e-263	-	3.1.13.5	-	J	ko:K03684	-	ko00000,ko01000,ko03016	3'-5' exonuclease
KOFIEAFP_00731	4.56e-139	-	-	-	S	ko:K07164	-	ko00000	C4-type zinc ribbon domain
KOFIEAFP_00732	2.22e-298	lpxK	2.7.1.130	-	M	ko:K00912	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
KOFIEAFP_00733	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
KOFIEAFP_00734	2.13e-118	-	-	-	-	-	-	-	-
KOFIEAFP_00735	3.46e-234	-	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	prohibitin homologues
KOFIEAFP_00736	0.000103	-	-	-	S	-	-	-	Entericidin EcnA/B family
KOFIEAFP_00738	1.07e-205	-	1.4.1.16	-	S	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
KOFIEAFP_00740	6.15e-140	-	-	-	Q	-	-	-	PA14
KOFIEAFP_00743	1.12e-104	-	-	-	-	-	-	-	-
KOFIEAFP_00744	0.0	mmyX	5.3.1.12	-	F	ko:K01812,ko:K07149,ko:K16139	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000,ko02000	Psort location Cytoplasmic, score
KOFIEAFP_00745	2.87e-112	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Cys-tRNA(Pro) hydrolase activity
KOFIEAFP_00746	2.5e-172	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Glutamine amidotransferase class-I
KOFIEAFP_00747	3e-118	-	-	-	T	ko:K07005	-	ko00000	pyridoxamine 5'-phosphate
KOFIEAFP_00748	2.5e-170	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
KOFIEAFP_00749	3.69e-268	-	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
KOFIEAFP_00750	8.49e-150	-	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Peptidase C26
KOFIEAFP_00751	1.21e-245	pabB	2.6.1.85, 4.1.3.27, 4.1.3.38	-	EH	ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KOFIEAFP_00752	8.83e-147	-	4.1.3.38	-	E	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	branched-chain-amino-acid transaminase activity
KOFIEAFP_00753	0.0	-	-	-	S	-	-	-	Protein of unknown function DUF262
KOFIEAFP_00754	1.64e-314	-	5.1.3.8	-	G	ko:K01787	ko00520,map00520	ko00000,ko00001,ko01000	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
KOFIEAFP_00755	1.38e-223	-	4.1.3.3	-	EM	ko:K01639	ko00520,map00520	ko00000,ko00001,ko01000	Dihydrodipicolinate synthetase family
KOFIEAFP_00756	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00757	9.24e-197	-	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
KOFIEAFP_00758	0.0	-	-	-	D	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00759	7.25e-303	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
KOFIEAFP_00760	0.0	-	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminus
KOFIEAFP_00761	2.52e-102	MA20_05485	-	-	S	-	-	-	Putative bacterial sensory transduction regulator
KOFIEAFP_00762	3.22e-248	-	-	-	M	-	-	-	HlyD family secretion protein
KOFIEAFP_00763	0.0	-	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	Helix-hairpin-helix class 2 (Pol1 family) motifs
KOFIEAFP_00764	7.42e-125	-	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Phosphoribosyl transferase domain
KOFIEAFP_00766	1.93e-143	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
KOFIEAFP_00767	2.64e-246	-	-	-	S	-	-	-	Imelysin
KOFIEAFP_00768	0.0	-	-	-	C	-	-	-	Di-haem oxidoreductase, putative peroxidase
KOFIEAFP_00769	8.48e-265	-	-	-	J	-	-	-	Endoribonuclease L-PSP
KOFIEAFP_00770	4.39e-219	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
KOFIEAFP_00771	1.23e-228	fatC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
KOFIEAFP_00772	1.5e-180	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
KOFIEAFP_00773	1.2e-209	fatB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion transport
KOFIEAFP_00774	5.88e-154	ccs1	-	-	O	ko:K07399	-	ko00000	cytochrome c biogenesis protein
KOFIEAFP_00775	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
KOFIEAFP_00776	1.58e-240	-	-	-	S	-	-	-	Acyltransferase family
KOFIEAFP_00777	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
KOFIEAFP_00778	1.12e-103	-	-	-	S	-	-	-	Protein of unknown function (DUF721)
KOFIEAFP_00779	1.33e-51	-	-	-	C	-	-	-	4Fe-4S single cluster domain of Ferredoxin I
KOFIEAFP_00780	0.0	-	-	GT2	M	ko:K03820	-	ko00000,ko01000	Carbon-nitrogen hydrolase
KOFIEAFP_00781	4.47e-176	-	-	-	S	-	-	-	Phosphodiester glycosidase
KOFIEAFP_00782	1.9e-229	-	2.7.7.13	-	JM	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
KOFIEAFP_00783	9.49e-317	fabZ	3.5.1.108, 4.2.1.59	-	IM	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
KOFIEAFP_00784	1.2e-226	-	-	-	G	-	-	-	pfkB family carbohydrate kinase
KOFIEAFP_00785	2.45e-77	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KOFIEAFP_00786	4.24e-275	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Iron-containing alcohol dehydrogenase
KOFIEAFP_00792	6.72e-210	-	-	-	L	ko:K04763	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
KOFIEAFP_00793	3.92e-271	-	2.1.1.72	-	H	ko:K07318	-	ko00000,ko01000,ko02048	PFAM D12 class N6 adenine-specific DNA methyltransferase
KOFIEAFP_00795	2.08e-240	BT0173	-	-	S	-	-	-	Psort location Cytoplasmic, score
KOFIEAFP_00796	5.27e-170	BT0174	-	-	C	ko:K04488	-	ko00000	iron-sulfur transferase activity
KOFIEAFP_00797	2.84e-200	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
KOFIEAFP_00799	8.29e-100	cysJ	1.8.1.2	-	C	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	hydroxylamine reductase activity
KOFIEAFP_00801	1.25e-261	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KOFIEAFP_00802	1.33e-52	-	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
KOFIEAFP_00803	1.65e-303	-	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
KOFIEAFP_00805	4.68e-315	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
KOFIEAFP_00806	1.28e-85	-	-	-	S	ko:K06940	-	ko00000	Putative zinc- or iron-chelating domain
KOFIEAFP_00809	5.03e-192	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Bacitracin resistance protein BacA
KOFIEAFP_00810	7.46e-238	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KOFIEAFP_00811	0.0	gltX	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KOFIEAFP_00812	0.0	kefA	-	-	M	ko:K05802,ko:K22051	-	ko00000,ko02000	cellular water homeostasis
KOFIEAFP_00813	1.78e-97	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	QueF-like protein
KOFIEAFP_00814	1.02e-159	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Queuosine biosynthesis protein QueC
KOFIEAFP_00815	9.88e-145	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KOFIEAFP_00816	0.0	-	-	-	J	-	-	-	Beta-Casp domain
KOFIEAFP_00817	1.23e-62	-	-	-	S	-	-	-	Protein of unknown function (DUF1232)
KOFIEAFP_00818	8.67e-160	-	-	-	S	-	-	-	Protein of unknown function (DUF4230)
KOFIEAFP_00819	3.9e-306	-	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate/isopropylmalate dehydrogenase
KOFIEAFP_00820	2.09e-266	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
KOFIEAFP_00821	2.04e-62	-	-	-	E	ko:K07032	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
KOFIEAFP_00823	0.0	-	-	-	C	-	-	-	Cytochrome c
KOFIEAFP_00824	4.49e-298	-	-	-	P	-	-	-	ABC-type Zn2 transport system, periplasmic component surface adhesin
KOFIEAFP_00825	3.17e-157	-	-	-	C	-	-	-	Cytochrome c
KOFIEAFP_00827	1.65e-314	-	-	-	C	ko:K00185	-	ko00000	Polysulphide reductase, NrfD
KOFIEAFP_00828	6.05e-250	-	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	chorismate binding enzyme
KOFIEAFP_00829	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 31
KOFIEAFP_00830	1.25e-315	-	-	-	G	-	-	-	Glycosyl transferase 4-like domain
KOFIEAFP_00831	8.59e-293	-	3.2.1.1	GH57	G	ko:K07405	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolase family 57
KOFIEAFP_00832	8.02e-130	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
KOFIEAFP_00833	2.12e-92	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
KOFIEAFP_00834	2.29e-136	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
KOFIEAFP_00835	2.25e-284	-	5.4.99.22	-	M	ko:K06178	-	ko00000,ko01000,ko03009	translation initiation factor activity
KOFIEAFP_00836	3.77e-118	-	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
KOFIEAFP_00837	1e-314	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
KOFIEAFP_00838	1.66e-144	-	-	-	S	ko:K09974	-	ko00000	Domain of unknown function (DUF1287)
KOFIEAFP_00839	0.0	fhs	6.3.4.3	-	H	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Formate--tetrahydrofolate ligase
KOFIEAFP_00840	1.65e-221	-	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Ketopantoate reductase PanE/ApbA C terminal
KOFIEAFP_00841	1.65e-208	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00842	1.4e-185	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
KOFIEAFP_00843	0.0	-	-	-	EP	ko:K13894	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_00844	0.0	-	-	-	P	ko:K13895	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_00845	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
KOFIEAFP_00846	9.42e-232	-	-	-	EP	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
KOFIEAFP_00847	6.48e-244	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
KOFIEAFP_00848	2.2e-274	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KOFIEAFP_00850	2.84e-210	-	-	-	EG	-	-	-	EamA-like transporter family
KOFIEAFP_00851	1.11e-283	-	-	-	Q	-	-	-	Multicopper oxidase
KOFIEAFP_00852	0.0	-	3.1.5.1	-	F	ko:K01129	ko00230,map00230	ko00000,ko00001,ko01000	Phosphohydrolase-associated domain
KOFIEAFP_00853	1e-228	-	-	-	O	-	-	-	Parallel beta-helix repeats
KOFIEAFP_00854	4.78e-222	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
KOFIEAFP_00856	1.07e-138	-	-	-	K	-	-	-	ECF sigma factor
KOFIEAFP_00857	1.32e-221	ytpP	2.7.1.180, 5.3.4.1	-	CO	ko:K01829,ko:K03671,ko:K03734,ko:K06196	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko02000,ko03110	cell redox homeostasis
KOFIEAFP_00858	0.0	-	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	ThiC-associated domain
KOFIEAFP_00859	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
KOFIEAFP_00860	7.29e-60	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	negative regulation of transcription, DNA-templated
KOFIEAFP_00861	3.97e-27	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
KOFIEAFP_00862	2.34e-134	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
KOFIEAFP_00863	0.0	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	N-terminal domain of BNR-repeat neuraminidase
KOFIEAFP_00864	4.55e-121	-	-	-	-	-	-	-	-
KOFIEAFP_00865	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
KOFIEAFP_00866	0.0	fucI	5.3.1.25, 5.3.1.3	-	G	ko:K01818	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KOFIEAFP_00867	0.0	-	2.7.1.51	-	G	ko:K00879	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
KOFIEAFP_00868	1.2e-200	-	-	-	G	-	-	-	Class II Aldolase and Adducin N-terminal domain
KOFIEAFP_00870	0.0	-	-	-	M	-	-	-	AsmA-like C-terminal region
KOFIEAFP_00871	1.84e-171	-	-	-	S	ko:K06911	-	ko00000	Pirin
KOFIEAFP_00873	2.05e-173	-	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	FtsJ-like methyltransferase
KOFIEAFP_00877	4.95e-216	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
KOFIEAFP_00878	6.71e-285	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
KOFIEAFP_00879	4.7e-57	-	-	-	S	ko:K06960	-	ko00000	KH domain
KOFIEAFP_00880	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_00881	0.0	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	RNA cap guanine-N2 methyltransferase
KOFIEAFP_00882	2.41e-213	-	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
KOFIEAFP_00883	3.32e-241	-	4.2.1.113	-	M	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Mandelate Racemase Muconate Lactonizing
KOFIEAFP_00884	0.0	-	-	-	G	-	-	-	Glycosyl hydrolase family 20, domain 2
KOFIEAFP_00886	0.0	-	-	-	V	-	-	-	Polysaccharide biosynthesis C-terminal domain
KOFIEAFP_00887	0.0	-	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
KOFIEAFP_00888	1.65e-102	-	-	-	G	-	-	-	single-species biofilm formation
KOFIEAFP_00889	7.97e-113	-	-	-	K	ko:K13640	-	ko00000,ko03000	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KOFIEAFP_00890	2.12e-131	-	-	-	S	-	-	-	Flavodoxin-like fold
KOFIEAFP_00891	3.98e-250	-	4.1.1.52	-	S	ko:K22213	-	ko00000,ko01000	Amidohydrolase
KOFIEAFP_00892	3.15e-229	tas	1.1.1.65	-	C	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	ko00000,ko00001,ko01000	Aldo Keto reductase
KOFIEAFP_00893	1.84e-187	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Cupin domain
KOFIEAFP_00894	4.49e-97	-	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
KOFIEAFP_00895	9.98e-129	-	-	-	C	-	-	-	FMN binding
KOFIEAFP_00896	4.2e-264	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
KOFIEAFP_00897	1.8e-271	-	-	-	C	-	-	-	Aldo/keto reductase family
KOFIEAFP_00898	2.97e-268	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
KOFIEAFP_00899	6.73e-208	-	-	-	S	-	-	-	Aldo/keto reductase family
KOFIEAFP_00900	2.33e-237	-	1.2.7.3	-	-	ko:K00176,ko:K07138	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	br01601,ko00000,ko00001,ko00002,ko01000	-
KOFIEAFP_00901	2.06e-303	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_00902	2.29e-141	-	-	-	M	-	-	-	polygalacturonase activity
KOFIEAFP_00904	2.07e-195	-	-	-	KT	-	-	-	Peptidase S24-like
KOFIEAFP_00905	6.03e-292	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_00908	5.63e-177	-	-	-	O	-	-	-	Trypsin
KOFIEAFP_00909	3.31e-239	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
KOFIEAFP_00910	6.2e-203	-	-	-	-	-	-	-	-
KOFIEAFP_00911	0.0	-	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
KOFIEAFP_00912	1.85e-282	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_00915	2.63e-10	-	-	-	-	-	-	-	-
KOFIEAFP_00917	2.36e-61	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KOFIEAFP_00918	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
KOFIEAFP_00919	1.01e-227	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
KOFIEAFP_00920	4.38e-211	-	-	-	S	-	-	-	Protein of unknown function DUF58
KOFIEAFP_00921	2.12e-129	-	-	-	-	-	-	-	-
KOFIEAFP_00922	2.3e-229	-	-	-	S	-	-	-	Protein of unknown function (DUF1194)
KOFIEAFP_00924	2.21e-41	-	-	-	S	ko:K07114	-	ko00000,ko02000	von Willebrand factor (vWF) type A domain
KOFIEAFP_00925	0.0	-	-	-	S	-	-	-	Oxygen tolerance
KOFIEAFP_00926	1.36e-204	yeaE	-	-	S	-	-	-	aldo-keto reductase (NADP) activity
KOFIEAFP_00927	0.0	-	6.1.1.14	-	J	ko:K01880	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Anticodon binding domain
KOFIEAFP_00928	8.72e-155	-	-	-	S	-	-	-	DUF218 domain
KOFIEAFP_00929	9.2e-208	-	-	-	S	-	-	-	CAAX protease self-immunity
KOFIEAFP_00930	3.2e-286	-	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Cys/Met metabolism PLP-dependent enzyme
KOFIEAFP_00931	8.26e-106	-	-	-	K	-	-	-	Lrp/AsnC ligand binding domain
KOFIEAFP_00932	0.0	-	-	-	L	-	-	-	SNF2 family N-terminal domain
KOFIEAFP_00933	8.46e-84	-	-	-	P	ko:K06195	-	ko00000	ApaG domain
KOFIEAFP_00934	7.47e-203	-	-	-	-	-	-	-	-
KOFIEAFP_00935	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
KOFIEAFP_00936	1.05e-192	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_00937	1.88e-135	-	-	-	K	ko:K07735	-	ko00000,ko03000	Uncharacterized ACR, COG1678
KOFIEAFP_00938	5.04e-164	-	-	-	S	ko:K06997	-	ko00000	Alanine racemase, N-terminal domain
KOFIEAFP_00939	0.0	-	-	-	S	-	-	-	50S ribosome-binding GTPase
KOFIEAFP_00940	1.17e-138	-	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	5-formyltetrahydrofolate cyclo-ligase family
KOFIEAFP_00941	8.83e-209	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_00942	0.0	-	-	-	E	-	-	-	Peptidase dimerisation domain
KOFIEAFP_00943	3.12e-223	hprK	-	-	T	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
KOFIEAFP_00944	8.72e-53	-	-	-	G	ko:K11189	-	ko00000,ko02000	PTS HPr component phosphorylation site
KOFIEAFP_00945	0.0	-	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KOFIEAFP_00946	0.0	-	-	-	P	-	-	-	Sulfatase
KOFIEAFP_00947	2.33e-223	-	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KOFIEAFP_00948	5.06e-94	-	-	-	S	ko:K02426	-	ko00000	Fe-S metabolism associated domain
KOFIEAFP_00950	0.0	-	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha amylase, C-terminal all-beta domain
KOFIEAFP_00951	1.69e-261	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
KOFIEAFP_00952	0.0	cobD	2.6.1.9, 2.7.7.74, 4.1.1.81	-	M	ko:K00817,ko:K04720,ko:K07281	ko00340,ko00350,ko00360,ko00400,ko00401,ko00562,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00562,map00860,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	nucleotidyl transferase
KOFIEAFP_00953	7.52e-266	odh	1.5.1.28	-	I	ko:K04940	-	ko00000,ko01000	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KOFIEAFP_00954	0.0	-	2.7.7.15	-	H	ko:K00968	ko00440,ko00564,ko01100,ko05231,map00440,map00564,map01100,map05231	ko00000,ko00001,ko00002,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
KOFIEAFP_00955	1.79e-226	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
KOFIEAFP_00956	3.44e-132	-	-	-	S	-	-	-	protein trimerization
KOFIEAFP_00958	4.51e-184	-	2.1.1.144, 2.1.1.197	-	FG	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	trans-aconitate 2-methyltransferase activity
KOFIEAFP_00959	0.0	-	2.7.7.9	-	G	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP--glucose-1-phosphate uridylyltransferase
KOFIEAFP_00960	3.94e-122	-	-	-	-	-	-	-	-
KOFIEAFP_00961	1.12e-63	-	-	-	J	-	-	-	RF-1 domain
KOFIEAFP_00962	1.79e-122	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KOFIEAFP_00963	4.48e-277	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
KOFIEAFP_00964	9.45e-300	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
KOFIEAFP_00965	1.19e-41	-	-	-	K	-	-	-	-acetyltransferase
KOFIEAFP_00966	1.15e-146	-	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KOFIEAFP_00967	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KOFIEAFP_00969	4.89e-237	-	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Delta-aminolevulinic acid dehydratase
KOFIEAFP_00971	2.04e-160	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
KOFIEAFP_00972	0.0	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
KOFIEAFP_00973	5.99e-231	-	4.1.1.35	-	M	ko:K08678	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko00002,ko01000	3-beta hydroxysteroid dehydrogenase/isomerase family
KOFIEAFP_00974	2.06e-181	-	-	-	I	-	-	-	Acyl-ACP thioesterase
KOFIEAFP_00977	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
KOFIEAFP_00978	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
KOFIEAFP_00979	0.0	-	-	-	D	-	-	-	nuclear chromosome segregation
KOFIEAFP_00980	2.94e-131	-	-	-	-	-	-	-	-
KOFIEAFP_00981	1.17e-245	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
KOFIEAFP_00984	1.8e-180	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyrroline-5-carboxylate reductase dimerisation
KOFIEAFP_00985	2.82e-160	-	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
KOFIEAFP_00986	5.51e-211	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
KOFIEAFP_00987	6.59e-227	-	-	-	S	-	-	-	Protein conserved in bacteria
KOFIEAFP_00988	2.01e-34	-	-	-	KLT	-	-	-	Tyrosine-protein kinase, subgroup, catalytic domain
KOFIEAFP_00989	0.0	-	4.1.99.1	-	E	ko:K01667	ko00380,map00380	ko00000,ko00001,ko01000	Beta-eliminating lyase
KOFIEAFP_00990	6.76e-143	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
KOFIEAFP_00991	2.04e-254	-	-	-	S	-	-	-	Domain of unknown function (DUF4105)
KOFIEAFP_00992	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	B3/4 domain
KOFIEAFP_00993	2.34e-240	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Aminoacyl tRNA synthetase class II, N-terminal domain
KOFIEAFP_00994	2.85e-286	-	-	-	P	ko:K03449	-	ko00000,ko02000	Major Facilitator Superfamily
KOFIEAFP_00995	1.72e-82	ykgB	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score 9.46
KOFIEAFP_00996	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
KOFIEAFP_00997	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Hsp90 protein
KOFIEAFP_00999	2.31e-74	-	-	-	L	-	-	-	Membrane
KOFIEAFP_01002	7.75e-258	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
KOFIEAFP_01003	5.59e-273	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KOFIEAFP_01004	9.25e-103	-	-	-	K	-	-	-	Transcriptional regulator
KOFIEAFP_01005	7.1e-311	-	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
KOFIEAFP_01006	3.21e-215	-	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
KOFIEAFP_01007	3.42e-135	thiE	2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17	-	H	ko:K00788,ko:K03147,ko:K14153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
KOFIEAFP_01008	1.29e-170	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KOFIEAFP_01009	4.27e-117	gepA	-	-	K	-	-	-	Phage-associated protein
KOFIEAFP_01011	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_01012	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_01013	4.91e-241	-	-	-	E	ko:K07588	-	ko00000,ko01000	ArgK protein
KOFIEAFP_01014	1.82e-112	-	-	-	F	ko:K08311	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	NUDIX domain
KOFIEAFP_01015	0.0	sepA	-	-	Q	-	-	-	COG2015, Alkyl sulfatase and related hydrolases
KOFIEAFP_01016	1.99e-121	-	-	-	-	-	-	-	-
KOFIEAFP_01017	1.71e-110	ruvC	3.1.22.4	-	L	ko:K01159	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KOFIEAFP_01018	4.25e-291	-	-	-	L	-	-	-	helicase superfamily c-terminal domain
KOFIEAFP_01019	8.17e-159	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
KOFIEAFP_01020	1.07e-241	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase
KOFIEAFP_01022	1.69e-107	-	-	-	K	-	-	-	DNA-binding transcription factor activity
KOFIEAFP_01023	2.43e-263	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Biotin-lipoyl like
KOFIEAFP_01024	0.0	-	-	-	V	-	-	-	AcrB/AcrD/AcrF family
KOFIEAFP_01025	4.13e-114	-	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Dihydrofolate reductase
KOFIEAFP_01026	5.77e-208	-	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Thymidylate synthase
KOFIEAFP_01027	0.0	-	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phospholipase D. Active site motifs.
KOFIEAFP_01028	0.0	-	4.1.1.3	-	C	ko:K01571	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	HMGL-like
KOFIEAFP_01030	0.0	-	-	-	V	ko:K03327	-	ko00000,ko02000	MatE
KOFIEAFP_01031	6.11e-256	-	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Iron-sulfur cluster assembly protein
KOFIEAFP_01032	6.78e-42	-	-	-	S	-	-	-	PurA ssDNA and RNA-binding protein
KOFIEAFP_01034	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	LeuA allosteric (dimerisation) domain
KOFIEAFP_01035	0.0	prlC	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
KOFIEAFP_01036	2.24e-282	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOFIEAFP_01037	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOFIEAFP_01038	0.0	-	-	-	MU	ko:K18139	ko01501,ko02024,map01501,map02024	ko00000,ko00001,ko00002,ko01504,ko02000	Outer membrane efflux protein
KOFIEAFP_01041	0.0	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
KOFIEAFP_01042	1.59e-150	-	-	-	-	-	-	-	-
KOFIEAFP_01044	1.34e-109	ptsN	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOFIEAFP_01045	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
KOFIEAFP_01047	0.000131	-	-	-	S	-	-	-	Protein of unknown function (DUF2971)
KOFIEAFP_01048	7.09e-253	-	-	-	L	-	-	-	Transposase IS200 like
KOFIEAFP_01049	0.0	-	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
KOFIEAFP_01051	9.61e-269	-	2.4.1.182	GT19	M	ko:K00748	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KOFIEAFP_01052	3.89e-149	dedA	-	-	S	-	-	-	FtsZ-dependent cytokinesis
KOFIEAFP_01053	6.7e-119	-	-	-	S	-	-	-	nitrogen fixation
KOFIEAFP_01054	1.01e-74	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KOFIEAFP_01055	8.68e-76	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KOFIEAFP_01056	1.08e-113	-	-	-	CO	-	-	-	cell redox homeostasis
KOFIEAFP_01058	7.09e-179	-	-	-	-	-	-	-	-
KOFIEAFP_01060	0.0	-	-	-	S	-	-	-	Bacteriophage head to tail connecting protein
KOFIEAFP_01062	3.45e-145	-	-	-	-	-	-	-	-
KOFIEAFP_01063	6.96e-64	-	-	-	K	-	-	-	DNA-binding transcription factor activity
KOFIEAFP_01065	5.87e-32	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KOFIEAFP_01066	4.79e-118	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KOFIEAFP_01067	4.91e-59	cas4	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	crispr-associated protein cas4
KOFIEAFP_01068	7.7e-84	cas3	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	DEAD-like helicases superfamily
KOFIEAFP_01069	1.21e-107	-	-	-	S	ko:K19119	-	ko00000,ko02048	CRISPR-associated protein (Cas_Cas5)
KOFIEAFP_01070	3.26e-134	csd1	3.5.1.28	-	M	ko:K01447,ko:K17733,ko:K19117	-	ko00000,ko01000,ko01002,ko01011,ko02048	N-Acetylmuramoyl-L-alanine amidase
KOFIEAFP_01071	1.07e-116	csd2	-	-	L	ko:K19118	-	ko00000,ko02048	CRISPR-associated protein, Csd2 family
KOFIEAFP_01089	2.37e-70	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Belongs to the N(4) N(6)-methyltransferase family
KOFIEAFP_01096	2.82e-79	-	-	-	S	-	-	-	Mu-like prophage FluMu protein gp28
KOFIEAFP_01115	2.28e-285	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
KOFIEAFP_01116	0.0	-	1.2.1.88, 1.5.5.2	-	CE	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko03000	Proline dehydrogenase
KOFIEAFP_01118	1.01e-45	-	-	-	S	-	-	-	R3H domain
KOFIEAFP_01119	0.0	-	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	Catalase
KOFIEAFP_01121	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
KOFIEAFP_01122	1.08e-136	rbr	-	-	C	-	-	-	Rubrerythrin
KOFIEAFP_01123	1.79e-143	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOFIEAFP_01125	0.0	-	-	-	D	ko:K03466	-	ko00000,ko03036	Ftsk_gamma
KOFIEAFP_01126	1.96e-180	-	-	-	M	ko:K01991	ko02026,map02026	ko00000,ko00001,ko02000	polysaccharide export
KOFIEAFP_01127	0.0	gumC	-	-	DM	ko:K16554	ko05111,map05111	ko00000,ko00001,ko02000	PFAM lipopolysaccharide biosynthesis protein
KOFIEAFP_01128	9.48e-165	-	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	protein tyrosine phosphatase activity
KOFIEAFP_01129	6.88e-176	-	-	-	M	-	-	-	Bacterial sugar transferase
KOFIEAFP_01130	4e-188	wbyL	-	GT2	M	ko:K13002	-	ko00000,ko01000,ko01003,ko01005	transferase activity, transferring glycosyl groups
KOFIEAFP_01131	1.47e-292	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
KOFIEAFP_01132	8.15e-285	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
KOFIEAFP_01133	1.42e-293	gtf1	2.4.1.52	GT4	M	ko:K00712	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
KOFIEAFP_01134	2.43e-241	-	-	-	-	-	-	-	-
KOFIEAFP_01135	3.06e-262	-	-	-	M	ko:K02847,ko:K13009	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	-O-antigen
KOFIEAFP_01136	1.52e-201	-	-	-	S	-	-	-	Glycosyl transferase family 11
KOFIEAFP_01137	5.61e-251	-	-	-	M	-	-	-	Glycosyl transferases group 1
KOFIEAFP_01138	2.42e-284	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
KOFIEAFP_01139	5.77e-289	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
KOFIEAFP_01140	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_01141	2.67e-113	-	-	-	S	ko:K03818	-	ko00000,ko01000	maltose O-acetyltransferase activity
KOFIEAFP_01142	4.4e-213	-	-	-	M	-	-	-	PFAM glycosyl transferase family 2
KOFIEAFP_01143	7e-243	-	-	-	M	-	-	-	Glycosyl transferase, family 2
KOFIEAFP_01144	1.04e-288	-	-	-	C	-	-	-	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_01145	0.0	-	-	-	S	-	-	-	polysaccharide biosynthetic process
KOFIEAFP_01146	1.21e-243	-	-	-	C	-	-	-	Nitroreductase family
KOFIEAFP_01147	0.0	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_01149	4.34e-284	-	-	-	S	-	-	-	very-long-chain-acyl-CoA dehydrogenase activity
KOFIEAFP_01150	2.93e-93	-	5.1.3.29	-	G	ko:K02431	-	ko00000,ko01000	RbsD / FucU transport protein family
KOFIEAFP_01151	1.1e-302	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_01152	0.0	-	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
KOFIEAFP_01153	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KOFIEAFP_01156	2.57e-315	-	1.1.1.40	-	C	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Malic enzyme, NAD binding domain
KOFIEAFP_01157	0.0	-	-	-	I	ko:K06889,ko:K09914	-	ko00000	PFAM Prenyltransferase squalene oxidase
KOFIEAFP_01158	6.91e-230	exsH	3.2.1.178, 3.2.1.18, 3.2.1.52	GH16,GH20,GH33	G	ko:K01186,ko:K12373,ko:K20830	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	xyloglucan:xyloglucosyl transferase activity
KOFIEAFP_01159	3.55e-257	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Glycosyl hydrolase family 3 N terminal domain
KOFIEAFP_01160	2.76e-129	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KOFIEAFP_01161	3.19e-159	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_01162	0.0	yidC	-	-	O	ko:K03217,ko:K06872	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	serine-type endopeptidase activity
KOFIEAFP_01163	5.56e-269	-	-	-	H	-	-	-	Elongator protein 3, MiaB family, Radical SAM
KOFIEAFP_01165	2.56e-309	-	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Seryl-tRNA synthetase N-terminal domain
KOFIEAFP_01166	5.79e-274	-	-	-	E	-	-	-	Alcohol dehydrogenase GroES-like domain
KOFIEAFP_01168	1.42e-215	-	3.5.1.53	-	K	ko:K12251	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
KOFIEAFP_01169	1.33e-231	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
KOFIEAFP_01170	1.86e-214	-	-	-	S	-	-	-	Protein of unknown function DUF58
KOFIEAFP_01171	2.63e-135	-	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	Peptidyl-tRNA hydrolase
KOFIEAFP_01172	0.0	-	-	-	M	-	-	-	Transglycosylase
KOFIEAFP_01173	0.0	-	3.4.24.3	-	NU	ko:K01387	-	ko00000,ko01000,ko01002,ko02042	translation initiation factor activity
KOFIEAFP_01174	0.0	-	-	-	H	-	-	-	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KOFIEAFP_01175	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KOFIEAFP_01177	0.0	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
KOFIEAFP_01178	2.95e-299	-	1.12.99.6	-	C	ko:K06282	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	NiFe/NiFeSe hydrogenase small subunit C-terminal
KOFIEAFP_01179	0.0	-	1.12.99.6	-	C	ko:K06281	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nickel-dependent hydrogenase
KOFIEAFP_01180	6.23e-288	hyaC	-	-	C	ko:K03620	ko02020,map02020	ko00000,ko00001	Prokaryotic cytochrome b561
KOFIEAFP_01181	3.4e-126	-	-	-	C	ko:K03605	-	ko00000,ko01000,ko01002	Hydrogenase maturation protease
KOFIEAFP_01182	2.09e-76	-	-	-	C	ko:K04651	-	ko00000,ko03110	Hydrogenase/urease nickel incorporation, metallochaperone, hypA
KOFIEAFP_01184	1.37e-86	-	-	-	S	ko:K09940	-	ko00000	Domain of unknown function (DUF4870)
KOFIEAFP_01185	6.15e-180	-	-	-	M	-	-	-	NLP P60 protein
KOFIEAFP_01186	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycosyl hydrolase family 20, domain 2
KOFIEAFP_01187	8.43e-155	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
KOFIEAFP_01188	1.7e-260	-	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_01192	2.57e-251	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_01194	1.9e-256	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Iron-containing alcohol dehydrogenase
KOFIEAFP_01196	1.21e-301	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
KOFIEAFP_01197	5.94e-178	-	-	-	C	-	-	-	Cytochrome c7 and related cytochrome c
KOFIEAFP_01198	0.0	-	-	-	C	ko:K00184	-	ko00000	4Fe-4S dicluster domain
KOFIEAFP_01200	0.0	-	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	RecG wedge domain
KOFIEAFP_01201	4.89e-167	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
KOFIEAFP_01202	0.0	pckG	4.1.1.32	-	C	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
KOFIEAFP_01204	7.44e-84	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	4'-phosphopantetheinyl transferase superfamily
KOFIEAFP_01205	5.64e-173	pdxJ	2.6.99.2	-	H	ko:K03474	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KOFIEAFP_01206	0.0	-	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	AICARFT/IMPCHase bienzyme
KOFIEAFP_01207	7.49e-95	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L9, N-terminal domain
KOFIEAFP_01208	1.05e-226	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
KOFIEAFP_01209	3.2e-209	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
KOFIEAFP_01210	2.13e-18	-	-	-	S	-	-	-	Lipocalin-like
KOFIEAFP_01212	8.77e-239	cbiM	-	-	P	ko:K02007,ko:K02009,ko:K16915	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt ion transport
KOFIEAFP_01213	3.84e-192	cbiQ	-	-	P	ko:K02007,ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transmembrane transporter activity
KOFIEAFP_01214	4.82e-179	cbiO	-	-	P	ko:K02006,ko:K02008,ko:K16784,ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPase activity
KOFIEAFP_01215	0.0	-	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	HELICc2
KOFIEAFP_01217	4.94e-210	ispE	2.7.1.148	-	I	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GHMP kinases N terminal domain
KOFIEAFP_01218	0.0	-	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	TopoisomeraseII
KOFIEAFP_01219	1.06e-173	-	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KOFIEAFP_01220	1.39e-258	-	2.7.7.13	-	M	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
KOFIEAFP_01221	2.13e-96	-	-	-	L	ko:K07447	-	ko00000,ko01000	Likely ribonuclease with RNase H fold.
KOFIEAFP_01222	9.07e-234	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
KOFIEAFP_01224	1.45e-55	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L28 family
KOFIEAFP_01225	1.04e-49	-	-	-	-	-	-	-	-
KOFIEAFP_01226	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Alpha galactosidase A
KOFIEAFP_01227	1.84e-221	-	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
KOFIEAFP_01228	0.0	-	-	-	E	-	-	-	Aminotransferase class I and II
KOFIEAFP_01229	4.6e-305	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
KOFIEAFP_01230	1.04e-78	divIC	-	-	D	ko:K05589,ko:K13052	-	ko00000,ko03036	cell cycle
KOFIEAFP_01232	0.0	-	-	-	P	-	-	-	Sulfatase
KOFIEAFP_01234	9.64e-153	-	-	-	K	-	-	-	Transcriptional regulator
KOFIEAFP_01235	5.9e-189	-	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_01236	1.35e-236	-	1.1.1.86	-	E	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KOFIEAFP_01237	8.5e-121	-	-	-	M	ko:K03098	-	ko00000,ko04147	Lipocalin-like domain
KOFIEAFP_01238	2.05e-191	-	-	-	S	ko:K07071	-	ko00000	Domain of unknown function (DUF1731)
KOFIEAFP_01239	5.75e-202	-	-	-	O	-	-	-	stress-induced mitochondrial fusion
KOFIEAFP_01241	4.01e-240	-	-	-	E	-	-	-	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOFIEAFP_01243	4.24e-296	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
KOFIEAFP_01244	1.37e-233	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
KOFIEAFP_01245	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_01246	4.2e-240	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
KOFIEAFP_01247	0.0	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
KOFIEAFP_01248	1.11e-205	-	-	-	S	-	-	-	Protein of unknown function DUF58
KOFIEAFP_01249	0.0	-	-	-	S	-	-	-	Aerotolerance regulator N-terminal
KOFIEAFP_01250	0.0	-	-	-	S	-	-	-	von Willebrand factor type A domain
KOFIEAFP_01251	5.94e-292	-	-	-	-	-	-	-	-
KOFIEAFP_01252	1.21e-260	-	4.1.2.48	-	E	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Beta-eliminating lyase
KOFIEAFP_01253	3.42e-83	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KOFIEAFP_01254	1.7e-281	-	-	-	C	-	-	-	Aldo/keto reductase family
KOFIEAFP_01255	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
KOFIEAFP_01256	2.74e-138	-	-	-	K	ko:K03088	-	ko00000,ko03021	DNA-templated transcription, initiation
KOFIEAFP_01257	2.43e-204	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
KOFIEAFP_01259	7.8e-237	-	2.7.11.1	-	T	ko:K08884,ko:K12132,ko:K20333	ko02024,map02024	ko00000,ko00001,ko01000,ko01001	PFAM Formylglycine-generating sulfatase enzyme
KOFIEAFP_01260	3.88e-263	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
KOFIEAFP_01261	2.54e-132	kdpC	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KOFIEAFP_01262	0.0	kdpB	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KOFIEAFP_01263	0.0	kdpA	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KOFIEAFP_01264	9.24e-26	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01268	1.92e-155	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01271	4.96e-120	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01274	0.0	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01275	0.0	-	-	-	M	-	-	-	pathogenesis
KOFIEAFP_01277	3.72e-265	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
KOFIEAFP_01283	2.56e-146	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
KOFIEAFP_01286	0.0	-	-	-	P	-	-	-	Cation transport protein
KOFIEAFP_01287	1.01e-299	-	-	-	V	ko:K03327	-	ko00000,ko02000	drug transmembrane transporter activity
KOFIEAFP_01288	7.82e-122	-	-	-	-	-	-	-	-
KOFIEAFP_01289	9.86e-54	-	-	-	-	-	-	-	-
KOFIEAFP_01290	2.82e-100	-	-	-	-	-	-	-	-
KOFIEAFP_01291	0.0	-	2.1.1.182	-	IJ	ko:K02528	-	ko00000,ko01000,ko03009	Ribosomal RNA adenine dimethylases
KOFIEAFP_01292	5.15e-247	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
KOFIEAFP_01293	0.0	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
KOFIEAFP_01294	0.0	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
KOFIEAFP_01295	6.39e-119	-	-	-	T	-	-	-	STAS domain
KOFIEAFP_01296	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF2851)
KOFIEAFP_01297	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
KOFIEAFP_01298	7.58e-291	-	-	-	-	-	-	-	-
KOFIEAFP_01299	0.0	-	-	-	M	-	-	-	Sulfatase
KOFIEAFP_01300	3.93e-280	-	4.1.99.19	-	H	ko:K03150	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Biotin and Thiamin Synthesis associated domain
KOFIEAFP_01301	2.3e-205	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
KOFIEAFP_01302	1.64e-267	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
KOFIEAFP_01303	0.0	-	-	-	T	-	-	-	pathogenesis
KOFIEAFP_01304	0.0	-	4.2.1.9	-	EG	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Dehydratase family
KOFIEAFP_01305	6.89e-168	-	-	-	T	ko:K07657	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
KOFIEAFP_01306	5.8e-289	-	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
KOFIEAFP_01307	2.09e-10	-	-	-	S	-	-	-	Mitochondrial domain of unknown function (DUF1713)
KOFIEAFP_01308	1.11e-206	hisG	2.4.2.17	-	E	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	ATP phosphoribosyltransferase
KOFIEAFP_01309	2.04e-314	-	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Aminopeptidase P, N-terminal domain
KOFIEAFP_01310	4.67e-154	-	-	-	S	-	-	-	Protein of unknown function (DUF3313)
KOFIEAFP_01311	5.91e-260	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KOFIEAFP_01312	7.71e-255	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
KOFIEAFP_01313	2.8e-169	-	-	-	-	-	-	-	-
KOFIEAFP_01314	0.0	-	-	-	NU	-	-	-	Type IV pilus assembly protein PilM;
KOFIEAFP_01315	1.06e-208	-	-	-	-	-	-	-	-
KOFIEAFP_01316	2.27e-245	-	-	-	-	-	-	-	-
KOFIEAFP_01317	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
KOFIEAFP_01318	7.55e-142	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KOFIEAFP_01319	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KOFIEAFP_01320	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
KOFIEAFP_01321	1.65e-240	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
KOFIEAFP_01322	1.1e-131	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
KOFIEAFP_01323	1.28e-227	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KOFIEAFP_01324	0.0	-	1.11.1.5	-	P	ko:K00428	-	ko00000,ko01000	Di-haem cytochrome c peroxidase
KOFIEAFP_01325	2.48e-40	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
KOFIEAFP_01326	1.15e-47	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
KOFIEAFP_01327	0.0	-	-	-	P	ko:K04759	-	ko00000,ko02000	Ferrous iron transport protein B C terminus
KOFIEAFP_01330	2.83e-303	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
KOFIEAFP_01332	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
KOFIEAFP_01333	9.94e-90	-	-	-	K	-	-	-	Helix-turn-helix diphteria tox regulatory element
KOFIEAFP_01334	1.25e-203	-	3.1.1.53	-	L	ko:K03547,ko:K05970	-	ko00000,ko01000,ko03400	3'-5' exonuclease activity
KOFIEAFP_01335	7.03e-134	-	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	SpoU rRNA Methylase family
KOFIEAFP_01336	0.0	-	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
KOFIEAFP_01337	9.76e-258	-	-	-	S	-	-	-	Glycoside-hydrolase family GH114
KOFIEAFP_01338	7.79e-304	-	-	-	M	-	-	-	Glycosyl transferases group 1
KOFIEAFP_01340	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RecQ zinc-binding
KOFIEAFP_01341	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
KOFIEAFP_01342	8.66e-227	-	-	-	-	-	-	-	-
KOFIEAFP_01343	0.0	-	-	-	H	-	-	-	Flavin containing amine oxidoreductase
KOFIEAFP_01344	2.18e-247	-	-	-	-	-	-	-	-
KOFIEAFP_01345	8.24e-248	rgpB	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
KOFIEAFP_01346	0.0	ahcY	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KOFIEAFP_01347	3.77e-291	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KOFIEAFP_01348	1.36e-214	-	-	-	KQ	-	-	-	Hypothetical methyltransferase
KOFIEAFP_01351	0.0	-	-	-	E	-	-	-	PFAM major facilitator superfamily MFS_1
KOFIEAFP_01352	3.17e-206	-	-	-	G	ko:K06867,ko:K07001	-	ko00000	response to abiotic stimulus
KOFIEAFP_01354	3.03e-295	-	-	-	MU	ko:K15725	-	ko00000,ko02000	efflux transmembrane transporter activity
KOFIEAFP_01355	1.96e-297	czcB	-	-	M	ko:K15727	-	ko00000,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOFIEAFP_01356	0.0	-	-	-	P	ko:K07239	-	ko00000	AcrB/AcrD/AcrF family
KOFIEAFP_01357	1.7e-146	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
KOFIEAFP_01359	3.95e-168	-	-	-	CO	-	-	-	Protein conserved in bacteria
KOFIEAFP_01360	2.6e-231	-	1.5.1.20	-	E	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
KOFIEAFP_01361	3.01e-153	-	1.14.11.27	-	P	ko:K10277	-	ko00000,ko01000,ko03036	peptidyl-arginine hydroxylation
KOFIEAFP_01362	0.0	-	-	-	M	ko:K07277	-	ko00000,ko02000,ko03029	Surface antigen
KOFIEAFP_01363	8.38e-282	tig	-	-	O	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
KOFIEAFP_01364	2.5e-153	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
KOFIEAFP_01365	0.0	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KOFIEAFP_01366	2.49e-256	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KOFIEAFP_01368	9.94e-287	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KOFIEAFP_01370	3.61e-46	-	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SecE/Sec61-gamma subunits of protein translocation complex
KOFIEAFP_01371	6.29e-135	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.
KOFIEAFP_01372	2.58e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KOFIEAFP_01373	1.74e-156	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
KOFIEAFP_01374	9.92e-110	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KOFIEAFP_01375	1.06e-63	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
KOFIEAFP_01377	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KOFIEAFP_01378	6.21e-39	-	-	-	-	-	-	-	-
KOFIEAFP_01379	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
KOFIEAFP_01381	9.83e-235	-	-	-	CO	-	-	-	Thioredoxin-like
KOFIEAFP_01382	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
KOFIEAFP_01383	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_01384	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
KOFIEAFP_01385	1.6e-75	-	-	-	G	-	-	-	Cupin 2, conserved barrel domain protein
KOFIEAFP_01386	5.74e-211	ybfH	-	-	EG	-	-	-	spore germination
KOFIEAFP_01387	9.28e-139	-	-	-	-	-	-	-	-
KOFIEAFP_01388	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
KOFIEAFP_01389	6.01e-120	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KOFIEAFP_01390	5.26e-188	-	-	-	O	ko:K04083	-	ko00000,ko03110	Hsp33 protein
KOFIEAFP_01393	2.41e-232	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
KOFIEAFP_01397	1.97e-128	-	-	-	U	ko:K05595	-	ko00000,ko02000	MarC family integral membrane protein
KOFIEAFP_01398	1.46e-178	-	4.2.99.20	-	I	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Alpha/beta hydrolase family
KOFIEAFP_01399	1.46e-75	-	-	-	S	ko:K09954	-	ko00000	Putative quorum-sensing-regulated virulence factor
KOFIEAFP_01401	1.24e-51	-	-	-	-	-	-	-	-
KOFIEAFP_01402	8.46e-133	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
KOFIEAFP_01403	3.25e-183	-	-	-	-	-	-	-	-
KOFIEAFP_01404	1.23e-172	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
KOFIEAFP_01405	1.88e-111	-	-	-	KT	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
KOFIEAFP_01406	7.68e-310	-	-	-	C	-	-	-	4 iron, 4 sulfur cluster binding
KOFIEAFP_01407	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
KOFIEAFP_01408	4.62e-223	-	-	-	K	-	-	-	Transcriptional regulator
KOFIEAFP_01409	4.25e-178	-	-	-	C	-	-	-	aldo keto reductase
KOFIEAFP_01410	5.2e-135	-	-	-	S	-	-	-	Alpha/beta hydrolase family
KOFIEAFP_01411	3.02e-277	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
KOFIEAFP_01412	3.93e-308	-	-	-	C	-	-	-	Carboxymuconolactone decarboxylase family
KOFIEAFP_01413	1.2e-158	-	-	-	IQ	-	-	-	Short chain dehydrogenase
KOFIEAFP_01414	8.88e-149	corC_1	-	-	P	ko:K03699	-	ko00000,ko02042	Psort location CytoplasmicMembrane, score
KOFIEAFP_01416	4.21e-137	-	-	-	J	ko:K05808	-	ko00000,ko03009	Sigma 54 modulation/S30EA ribosomal protein C terminus
KOFIEAFP_01418	2.17e-08	-	-	-	M	-	-	-	major outer membrane lipoprotein
KOFIEAFP_01419	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
KOFIEAFP_01421	2.57e-170	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	KR domain
KOFIEAFP_01422	3.88e-308	-	-	-	C	-	-	-	Sulfatase-modifying factor enzyme 1
KOFIEAFP_01423	1.13e-15	-	-	-	S	ko:K03824	-	ko00000,ko01000	PFAM GCN5-related N-acetyltransferase
KOFIEAFP_01424	1.31e-40	-	-	-	K	-	-	-	Acetyltransferase (GNAT) family
KOFIEAFP_01425	1.15e-05	-	-	-	-	-	-	-	-
KOFIEAFP_01426	4.52e-262	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
KOFIEAFP_01427	4.91e-315	mnmE	-	-	J	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KOFIEAFP_01428	3.95e-13	-	-	-	S	-	-	-	Mac 1
KOFIEAFP_01429	2.82e-154	-	-	-	S	-	-	-	UPF0126 domain
KOFIEAFP_01430	5.27e-189	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
KOFIEAFP_01431	4.54e-105	-	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
KOFIEAFP_01432	0.0	rsmH	2.1.1.199	-	M	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
KOFIEAFP_01434	0.0	-	3.4.16.4	-	M	ko:K03587	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011,ko03036	Penicillin-binding Protein dimerisation domain
KOFIEAFP_01435	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KOFIEAFP_01436	0.0	-	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Mur ligase middle domain
KOFIEAFP_01437	1.99e-261	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KOFIEAFP_01438	1.45e-314	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KOFIEAFP_01439	1e-160	mltD	-	CBM50	M	ko:K08307,ko:K12204,ko:K19224	-	ko00000,ko01000,ko01002,ko01011,ko02044	LysM domain
KOFIEAFP_01440	1.33e-277	-	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Cell cycle protein
KOFIEAFP_01441	5.55e-267	-	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KOFIEAFP_01442	0.0	murB	-	-	M	-	-	-	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
KOFIEAFP_01443	1.44e-228	ddl	6.3.2.4	-	M	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	D-ala D-ala ligase N-terminus
KOFIEAFP_01444	1.8e-216	-	-	-	M	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	POTRA domain, FtsQ-type
KOFIEAFP_01445	1.15e-238	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KOFIEAFP_01446	6.69e-239	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
KOFIEAFP_01447	2.91e-140	-	2.3.1.181	-	H	ko:K03801	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
KOFIEAFP_01448	0.0	-	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase family (aconitate hydratase)
KOFIEAFP_01449	1.53e-146	-	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
KOFIEAFP_01450	4.99e-274	-	-	-	-	-	-	-	-
KOFIEAFP_01451	0.0	-	-	-	O	-	-	-	Trypsin
KOFIEAFP_01452	0.0	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
KOFIEAFP_01453	6.43e-284	-	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	3-dehydroquinate synthase
KOFIEAFP_01455	2.65e-174	-	-	-	E	-	-	-	ATPases associated with a variety of cellular activities
KOFIEAFP_01456	2.05e-198	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KOFIEAFP_01457	5.88e-163	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S2
KOFIEAFP_01458	3.62e-173	cbiX	4.99.1.3	-	S	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	sirohydrochlorin cobaltochelatase activity
KOFIEAFP_01459	6.68e-198	-	2.5.1.55	-	M	ko:K01627	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	DAHP synthetase I family
KOFIEAFP_01462	6.31e-171	-	-	-	S	ko:K06861	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_01463	6.55e-221	-	-	-	E	-	-	-	Phosphoserine phosphatase
KOFIEAFP_01464	0.0	-	6.3.2.45	-	M	ko:K02558	-	ko00000,ko01000	Mur ligase family, catalytic domain
KOFIEAFP_01465	7.64e-307	-	-	-	M	-	-	-	OmpA family
KOFIEAFP_01466	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
KOFIEAFP_01467	2.27e-86	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
KOFIEAFP_01468	3.34e-117	ywrF	-	-	S	-	-	-	FMN binding
KOFIEAFP_01469	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
KOFIEAFP_01470	0.0	-	-	-	T	-	-	-	pathogenesis
KOFIEAFP_01472	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
KOFIEAFP_01473	5.48e-296	-	-	-	-	-	-	-	-
KOFIEAFP_01474	5.12e-71	-	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Thioredoxin-like domain
KOFIEAFP_01476	5.24e-159	-	-	-	S	-	-	-	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KOFIEAFP_01477	2.64e-255	-	-	-	M	ko:K02022	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOFIEAFP_01478	8.42e-302	-	4.2.1.129, 5.4.99.17, 5.5.1.16	-	I	ko:K06045,ko:K17811	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
KOFIEAFP_01479	0.0	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
KOFIEAFP_01480	4.25e-144	-	3.2.1.23	-	M	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
KOFIEAFP_01483	1.31e-213	-	-	-	K	-	-	-	LysR substrate binding domain
KOFIEAFP_01484	5.45e-234	-	-	-	S	-	-	-	Conserved hypothetical protein 698
KOFIEAFP_01485	7.38e-252	-	-	-	E	-	-	-	Aminotransferase class-V
KOFIEAFP_01486	1.48e-311	-	-	-	S	-	-	-	Protein of unknown function (DUF1015)
KOFIEAFP_01487	0.0	-	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
KOFIEAFP_01488	2.69e-181	-	2.7.13.3	-	Q	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Transposase
KOFIEAFP_01489	2.32e-167	-	4.3.99.3	-	O	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
KOFIEAFP_01490	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KOFIEAFP_01491	5.84e-173	-	-	-	K	-	-	-	Transcriptional regulator
KOFIEAFP_01492	0.0	-	-	-	P	-	-	-	Dimerisation domain of Zinc Transporter
KOFIEAFP_01493	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
KOFIEAFP_01495	3.89e-242	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KOFIEAFP_01496	1.79e-201	-	-	-	S	-	-	-	SigmaW regulon antibacterial
KOFIEAFP_01498	4.54e-173	-	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Thiazole biosynthesis protein ThiG
KOFIEAFP_01499	5.41e-293	-	-	-	E	-	-	-	Amino acid permease
KOFIEAFP_01500	1.98e-156	gph	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
KOFIEAFP_01501	6.62e-257	-	-	-	S	ko:K11744	-	ko00000	AI-2E family transporter
KOFIEAFP_01502	1.62e-312	-	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
KOFIEAFP_01503	1.32e-235	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
KOFIEAFP_01504	0.0	-	-	-	T	ko:K06207	-	ko00000	Elongation factor G C-terminus
KOFIEAFP_01505	4.07e-212	-	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KOFIEAFP_01506	5.11e-222	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
KOFIEAFP_01507	6.6e-129	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KOFIEAFP_01508	1.59e-137	-	-	-	T	-	-	-	histone H2A K63-linked ubiquitination
KOFIEAFP_01510	3.23e-253	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KOFIEAFP_01511	2.84e-286	-	-	-	S	-	-	-	Phosphotransferase enzyme family
KOFIEAFP_01512	4.45e-254	-	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
KOFIEAFP_01513	4.18e-266	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
KOFIEAFP_01518	5.36e-146	-	-	-	C	-	-	-	e3 binding domain
KOFIEAFP_01519	3.93e-128	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
KOFIEAFP_01520	3.2e-267	-	-	-	S	-	-	-	PFAM glycosyl transferase family 2
KOFIEAFP_01521	7.39e-296	-	-	-	-	-	-	-	-
KOFIEAFP_01522	2.94e-264	-	-	-	S	-	-	-	Glycosyltransferase like family 2
KOFIEAFP_01523	3.06e-226	-	-	-	S	-	-	-	Glycosyl transferase family 11
KOFIEAFP_01524	1.89e-275	-	-	GT2	S	ko:K19427	-	ko00000,ko01000	PFAM glycosyl transferase family 2
KOFIEAFP_01526	8.71e-283	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
KOFIEAFP_01527	0.0	-	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Polyphosphate kinase middle domain
KOFIEAFP_01528	0.0	-	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	Ppx/GppA phosphatase family
KOFIEAFP_01529	2.72e-262	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_01530	1.29e-192	map	3.4.11.18	-	J	ko:K01265	-	ko00000,ko01000,ko01002	Metallopeptidase family M24
KOFIEAFP_01531	6.41e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
KOFIEAFP_01532	0.0	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
KOFIEAFP_01534	6.42e-101	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
KOFIEAFP_01535	3.38e-102	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KOFIEAFP_01536	2.38e-74	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KOFIEAFP_01537	2.25e-105	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KOFIEAFP_01538	4.08e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KOFIEAFP_01539	5.36e-138	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KOFIEAFP_01540	1.53e-47	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S L24/mitochondrial 39S L24
KOFIEAFP_01541	4.9e-207	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KOFIEAFP_01542	1.77e-124	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
KOFIEAFP_01543	0.0	-	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Calcineurin-like phosphoesterase
KOFIEAFP_01544	0.0	-	2.7.11.1	-	L	ko:K08282	-	ko00000,ko01000	SNF2 Helicase protein
KOFIEAFP_01545	0.0	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
KOFIEAFP_01547	1.53e-286	-	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Mur ligase middle domain
KOFIEAFP_01548	0.0	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Collagenase
KOFIEAFP_01550	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
KOFIEAFP_01551	7.63e-74	-	-	-	L	-	-	-	Cupin 2, conserved barrel domain protein
KOFIEAFP_01552	7.1e-130	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
KOFIEAFP_01554	1.01e-294	-	-	-	EGP	-	-	-	Major facilitator Superfamily
KOFIEAFP_01555	4.75e-215	-	-	-	K	-	-	-	LysR substrate binding domain
KOFIEAFP_01556	1.17e-271	-	-	-	S	-	-	-	tRNA-splicing ligase RtcB
KOFIEAFP_01557	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
KOFIEAFP_01560	2.93e-283	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KOFIEAFP_01562	2.57e-133	-	-	-	D	-	-	-	ErfK ybiS ycfS ynhG family protein
KOFIEAFP_01563	0.0	-	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
KOFIEAFP_01564	8.8e-169	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
KOFIEAFP_01568	0.0	-	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Bacterial DNA topoisomeraes I ATP-binding domain
KOFIEAFP_01569	9.54e-102	-	-	-	-	-	-	-	-
KOFIEAFP_01570	0.0	-	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase HemD
KOFIEAFP_01571	6.42e-101	-	-	-	S	-	-	-	peptidase
KOFIEAFP_01572	5.18e-172	-	-	-	S	ko:K06973	-	ko00000	Putative neutral zinc metallopeptidase
KOFIEAFP_01573	2.1e-99	-	-	-	S	-	-	-	peptidase
KOFIEAFP_01574	0.0	-	-	-	S	-	-	-	pathogenesis
KOFIEAFP_01575	0.0	-	-	-	V	ko:K18095	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	AcrB/AcrD/AcrF family
KOFIEAFP_01576	1e-242	-	-	-	M	ko:K18094	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	Biotin-lipoyl like
KOFIEAFP_01577	1.23e-143	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KOFIEAFP_01578	1.66e-39	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KOFIEAFP_01579	1.13e-221	-	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
KOFIEAFP_01580	9.47e-236	-	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
KOFIEAFP_01581	1.63e-298	-	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
KOFIEAFP_01582	4.72e-206	-	-	-	S	ko:K09949	-	ko00000	Protein of unknown function (DUF1009)
KOFIEAFP_01585	1.34e-90	-	-	-	-	-	-	-	-
KOFIEAFP_01586	2.14e-171	yyaQ	-	-	V	-	-	-	Protein conserved in bacteria
KOFIEAFP_01587	1.76e-192	-	-	-	M	-	-	-	Glycosyl transferase WecB/TagA/CpsF family
KOFIEAFP_01588	3.71e-190	-	3.1.4.55	-	S	ko:K06167	ko00440,map00440	ko00000,ko00001,ko01000	Metallo-beta-lactamase superfamily
KOFIEAFP_01589	0.0	-	-	-	L	ko:K03631	-	ko00000,ko03400	RecF/RecN/SMC N terminal domain
KOFIEAFP_01590	0.0	-	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
KOFIEAFP_01591	1.16e-244	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
KOFIEAFP_01592	9.29e-132	-	-	-	J	ko:K02356	-	ko00000,ko03012	Elongation factor P (EF-P) OB domain
KOFIEAFP_01593	1.2e-105	-	-	-	S	-	-	-	ACT domain protein
KOFIEAFP_01594	4.8e-313	-	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
KOFIEAFP_01595	3.06e-85	-	-	-	M	ko:K03282	-	ko00000,ko02000	Large-conductance mechanosensitive channel, MscL
KOFIEAFP_01596	1.44e-277	-	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Alkaline phosphatase homologues
KOFIEAFP_01597	4.06e-287	-	-	-	EGP	-	-	-	Major facilitator Superfamily
KOFIEAFP_01598	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_01599	8.88e-268	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
KOFIEAFP_01601	1.96e-121	ngr	-	-	C	-	-	-	Rubrerythrin
KOFIEAFP_01603	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF1705)
KOFIEAFP_01604	0.0	-	-	-	M	-	-	-	Glycosyl Hydrolase Family 88
KOFIEAFP_01605	0.0	-	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Anaerobic ribonucleoside-triphosphate reductase
KOFIEAFP_01606	3.8e-43	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	CTP reductase activity
KOFIEAFP_01607	1.07e-188	-	1.97.1.4	-	O	ko:K04069	-	ko00000,ko01000	Radical SAM superfamily
KOFIEAFP_01608	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
KOFIEAFP_01609	0.0	-	-	-	T	-	-	-	Histidine kinase
KOFIEAFP_01610	4.64e-111	-	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
KOFIEAFP_01611	0.0	-	-	-	P	ko:K07085	-	ko00000	Predicted Permease Membrane Region
KOFIEAFP_01612	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Glycosyl hydrolase family 36 N-terminal domain
KOFIEAFP_01613	2.56e-55	himA	-	-	L	ko:K03530,ko:K04764,ko:K05788	-	ko00000,ko03032,ko03036,ko03400	regulation of translation
KOFIEAFP_01614	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_01615	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
KOFIEAFP_01616	2.42e-188	-	-	-	V	-	-	-	AAA domain
KOFIEAFP_01617	9.03e-95	-	3.1.21.3	-	L	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
KOFIEAFP_01618	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	COG0286 Type I restriction-modification system methyltransferase subunit
KOFIEAFP_01621	3.31e-303	-	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	tRNA (Uracil-5-)-methyltransferase
KOFIEAFP_01622	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KOFIEAFP_01623	0.0	-	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein
KOFIEAFP_01624	3.29e-258	-	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
KOFIEAFP_01625	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
KOFIEAFP_01626	1.47e-204	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KOFIEAFP_01627	1.22e-307	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
KOFIEAFP_01628	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_01629	3.7e-165	-	-	-	S	-	-	-	SWIM zinc finger
KOFIEAFP_01630	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Argininosuccinate lyase C-terminal
KOFIEAFP_01631	0.0	-	-	-	U	ko:K03321	-	ko00000,ko02000	Sulfate permease family
KOFIEAFP_01632	8.76e-126	-	-	-	-	-	-	-	-
KOFIEAFP_01633	1.04e-109	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KOFIEAFP_01635	0.0	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
KOFIEAFP_01639	5.66e-19	leuA	2.3.3.13, 2.3.3.14	-	H	ko:K01649,ko:K02594	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KOFIEAFP_01640	0.0	-	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
KOFIEAFP_01641	0.0	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
KOFIEAFP_01642	5.64e-227	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Zinc-uptake complex component A periplasmic
KOFIEAFP_01643	3.38e-99	-	-	-	-	-	-	-	-
KOFIEAFP_01644	1.25e-191	-	-	-	P	ko:K09820	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
KOFIEAFP_01645	3.84e-180	-	-	-	P	ko:K09819	-	ko00000,ko00002,ko02000	FecCD transport family
KOFIEAFP_01646	5.46e-126	-	-	-	S	ko:K19411	-	ko00000	UvrB/uvrC motif
KOFIEAFP_01647	8.21e-246	-	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	ATP:guanido phosphotransferase, C-terminal catalytic domain
KOFIEAFP_01648	0.0	-	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	C-terminal, D2-small domain, of ClpB protein
KOFIEAFP_01649	0.0	-	3.2.1.50	-	G	ko:K01205	ko00531,ko01100,ko04142,map00531,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha-L-fucosidase
KOFIEAFP_01650	7.02e-75	-	-	-	P	ko:K03972	-	ko00000	Rhodanese Homology Domain
KOFIEAFP_01651	4.41e-203	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
KOFIEAFP_01652	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	HMGL-like
KOFIEAFP_01653	6.32e-224	-	-	-	CO	-	-	-	amine dehydrogenase activity
KOFIEAFP_01654	8.39e-89	-	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
KOFIEAFP_01655	1.06e-165	-	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
KOFIEAFP_01656	2.53e-204	-	-	-	GM	-	-	-	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KOFIEAFP_01657	1.02e-233	-	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (W and Y)
KOFIEAFP_01658	1.56e-103	-	-	-	T	-	-	-	Universal stress protein family
KOFIEAFP_01659	8.38e-190	-	-	-	S	ko:K09769	-	ko00000	YmdB-like protein
KOFIEAFP_01660	2.91e-184	-	-	-	H	ko:K22132	-	ko00000,ko03016	ThiF family
KOFIEAFP_01661	9.9e-121	-	-	-	-	-	-	-	-
KOFIEAFP_01663	1.17e-231	-	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
KOFIEAFP_01664	3.09e-122	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
KOFIEAFP_01665	3.77e-289	kbl	2.3.1.29	-	E	ko:K00639	ko00260,map00260	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
KOFIEAFP_01666	0.0	-	-	-	KLT	-	-	-	Sulfatase-modifying factor enzyme 1
KOFIEAFP_01667	1.06e-182	-	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	AAA domain
KOFIEAFP_01668	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
KOFIEAFP_01675	1.04e-54	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	thiamine diphosphate biosynthetic process
KOFIEAFP_01676	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KOFIEAFP_01677	0.0	-	-	-	M	ko:K02847,ko:K13009,ko:K16705	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	-O-antigen
KOFIEAFP_01678	8.67e-85	-	-	-	S	-	-	-	Protein of unknown function, DUF488
KOFIEAFP_01679	2.07e-235	-	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Porphobilinogen deaminase, dipyromethane cofactor binding domain
KOFIEAFP_01680	4.9e-241	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Glutamyl-tRNAGlu reductase, N-terminal domain
KOFIEAFP_01681	5.87e-178	-	-	-	S	-	-	-	Cytochrome C assembly protein
KOFIEAFP_01682	3.84e-189	folE2	3.5.4.16	-	S	ko:K09007	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Type I GTP cyclohydrolase folE2
KOFIEAFP_01683	4.52e-49	-	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S18
KOFIEAFP_01684	5.67e-33	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L33
KOFIEAFP_01685	1.46e-118	-	-	-	T	-	-	-	Prokaryotic dksA/traR C4-type zinc finger
KOFIEAFP_01686	5.9e-232	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
KOFIEAFP_01687	2.86e-245	sun	2.1.1.176, 2.1.1.178	-	J	ko:K03500,ko:K11392	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KOFIEAFP_01688	4.56e-125	-	-	-	S	ko:K07095	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
KOFIEAFP_01689	5.75e-98	nudI	3.6.1.55	-	F	ko:K03574,ko:K12944	-	ko00000,ko01000,ko03400	GDP-mannose mannosyl hydrolase activity
KOFIEAFP_01691	3.51e-284	-	-	-	M	ko:K02005	-	ko00000	HlyD family secretion protein
KOFIEAFP_01692	2.12e-162	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_01693	3.42e-313	-	-	-	V	-	-	-	MacB-like periplasmic core domain
KOFIEAFP_01694	9.1e-317	-	-	-	MU	-	-	-	Outer membrane efflux protein
KOFIEAFP_01695	4.7e-286	-	-	-	V	-	-	-	Beta-lactamase
KOFIEAFP_01696	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOFIEAFP_01697	1.04e-283	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOFIEAFP_01698	8.35e-94	-	-	-	K	-	-	-	DNA-binding transcription factor activity
KOFIEAFP_01699	4.86e-163	-	-	-	S	-	-	-	Uncharacterised protein family UPF0066
KOFIEAFP_01700	5.56e-306	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydro-orotase-like
KOFIEAFP_01701	1.55e-222	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
KOFIEAFP_01702	1.15e-122	-	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Phosphoribosyl transferase domain
KOFIEAFP_01703	1.52e-89	-	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR carboxylase
KOFIEAFP_01705	0.0	-	-	-	H	ko:K07137	-	ko00000	5-formyltetrahydrofolate cyclo-ligase activity
KOFIEAFP_01706	2.16e-266	-	3.5.3.12	-	E	ko:K10536	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Porphyromonas-type peptidyl-arginine deiminase
KOFIEAFP_01707	2.11e-89	-	-	-	-	-	-	-	-
KOFIEAFP_01708	0.0	rseP	3.4.21.116	-	M	ko:K06399,ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	metalloendopeptidase activity
KOFIEAFP_01709	3.9e-303	-	-	-	S	-	-	-	AI-2E family transporter
KOFIEAFP_01710	0.0	-	-	-	P	-	-	-	Domain of unknown function
KOFIEAFP_01712	8.19e-81	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
KOFIEAFP_01713	7.87e-313	-	-	-	G	-	-	-	cellulose 1,4-beta-cellobiosidase activity
KOFIEAFP_01714	1.91e-186	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
KOFIEAFP_01716	1.83e-74	-	-	-	-	-	-	-	-
KOFIEAFP_01717	0.0	-	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	DNA Topoisomerase IV
KOFIEAFP_01719	1.34e-134	-	-	-	S	-	-	-	Glycosyl hydrolase 108
KOFIEAFP_01722	1.83e-202	-	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	ParB-like nuclease domain
KOFIEAFP_01723	8.76e-236	-	-	-	S	-	-	-	Peptidase family M28
KOFIEAFP_01724	0.0	-	-	-	M	-	-	-	Aerotolerance regulator N-terminal
KOFIEAFP_01725	0.0	-	-	-	S	-	-	-	Large extracellular alpha-helical protein
KOFIEAFP_01728	9.48e-237	-	-	-	S	ko:K14347	-	ko00000,ko02000,ko04147	SBF-like CPA transporter family (DUF4137)
KOFIEAFP_01729	9.2e-273	-	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	tRNA synthetases class I (W and Y)
KOFIEAFP_01730	1.01e-84	-	-	-	S	ko:K09922	-	ko00000	Putative member of DMT superfamily (DUF486)
KOFIEAFP_01731	1.32e-212	-	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
KOFIEAFP_01732	2.27e-217	-	-	-	EP	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
KOFIEAFP_01733	0.0	-	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
KOFIEAFP_01734	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
KOFIEAFP_01735	1.53e-219	-	-	-	O	-	-	-	Thioredoxin-like domain
KOFIEAFP_01736	1.86e-310	-	1.5.1.7	-	E	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Saccharopine dehydrogenase C-terminal domain
KOFIEAFP_01737	7.11e-235	-	-	-	S	ko:K01128	-	ko00000,ko01000	acid phosphatase activity
KOFIEAFP_01740	0.0	-	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Tubulin/FtsZ family, GTPase domain
KOFIEAFP_01741	3.38e-294	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
KOFIEAFP_01742	1.72e-147	-	-	-	M	-	-	-	NLP P60 protein
KOFIEAFP_01743	0.0	-	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
KOFIEAFP_01744	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
KOFIEAFP_01745	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
KOFIEAFP_01746	0.0	-	-	-	H	-	-	-	NAD synthase
KOFIEAFP_01747	2.58e-168	-	-	-	Q	ko:K02066	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Permease MlaE
KOFIEAFP_01748	4.3e-190	-	-	-	Q	ko:K02065	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
KOFIEAFP_01749	1.82e-229	-	-	-	Q	ko:K02067	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MlaD protein
KOFIEAFP_01750	2.69e-38	-	-	-	T	-	-	-	ribosome binding
KOFIEAFP_01761	6.15e-10	-	-	-	L	ko:K07455	-	ko00000,ko03400	RecT family
KOFIEAFP_01763	2.99e-29	-	-	-	-	-	-	-	-
KOFIEAFP_01766	1.72e-12	-	-	-	-	-	-	-	-
KOFIEAFP_01767	3.47e-70	-	-	-	Q	-	-	-	DNA (cytosine-5-)-methyltransferase activity
KOFIEAFP_01768	4.92e-27	-	-	-	-	-	-	-	-
KOFIEAFP_01773	5.18e-12	xtmB	-	-	S	ko:K06909	-	ko00000	DNA packaging
KOFIEAFP_01789	9.76e-17	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
KOFIEAFP_01796	1.09e-05	-	-	-	L	ko:K14059	-	ko00000	Belongs to the 'phage' integrase family
KOFIEAFP_01798	2.89e-308	-	-	-	E	ko:K03310	-	ko00000	Sodium:alanine symporter family
KOFIEAFP_01799	2.43e-95	-	-	-	K	-	-	-	-acetyltransferase
KOFIEAFP_01800	8.6e-222	-	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Glutaminase
KOFIEAFP_01801	0.0	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	amino acid
KOFIEAFP_01802	0.0	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01803	1.04e-240	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01806	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Prolyl-tRNA synthetase, C-terminal
KOFIEAFP_01807	2.04e-158	-	-	-	S	-	-	-	Peptidase family M50
KOFIEAFP_01809	6.79e-217	-	-	-	JM	-	-	-	Nucleotidyl transferase
KOFIEAFP_01810	2.88e-273	-	-	-	S	-	-	-	Phosphotransferase enzyme family
KOFIEAFP_01811	3.51e-223	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
KOFIEAFP_01813	0.0	-	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
KOFIEAFP_01814	5.87e-296	-	-	-	-	-	-	-	-
KOFIEAFP_01815	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_01816	1.03e-138	mntP	-	-	P	-	-	-	manganese ion transmembrane transporter activity
KOFIEAFP_01818	5.51e-193	-	-	-	S	-	-	-	Phenazine biosynthesis-like protein
KOFIEAFP_01819	2.83e-177	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
KOFIEAFP_01820	0.0	-	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	Sigma-54 factor, Activator interacting domain (AID)
KOFIEAFP_01821	5.48e-273	ycaD	-	-	EGP	ko:K08219	-	ko00000,ko02000	Major facilitator Superfamily
KOFIEAFP_01822	2.03e-223	-	3.4.11.10, 3.4.11.6	-	DZ	ko:K19701	-	ko00000,ko01000,ko01002	aminopeptidase activity
KOFIEAFP_01823	1.71e-289	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
KOFIEAFP_01824	0.0	-	-	-	S	-	-	-	inositol 2-dehydrogenase activity
KOFIEAFP_01826	2.25e-284	-	3.6.4.13	-	L	ko:K11927	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	helicase superfamily c-terminal domain
KOFIEAFP_01828	3.6e-145	-	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	CDP-alcohol phosphatidyltransferase
KOFIEAFP_01829	0.0	-	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KOFIEAFP_01830	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
KOFIEAFP_01831	9.77e-278	-	4.2.1.51, 5.4.99.5	-	E	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase type II
KOFIEAFP_01832	3.72e-237	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
KOFIEAFP_01833	1.91e-191	-	-	-	S	-	-	-	NIF3 (NGG1p interacting factor 3)
KOFIEAFP_01834	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4340)
KOFIEAFP_01835	0.0	-	-	-	N	-	-	-	ABC-type uncharacterized transport system
KOFIEAFP_01836	2.49e-183	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
KOFIEAFP_01837	1.09e-223	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
KOFIEAFP_01838	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KOFIEAFP_01839	2.38e-133	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	nUDIX hydrolase
KOFIEAFP_01841	1.01e-251	-	2.3.1.1	-	E	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetyltransferase (GNAT) family
KOFIEAFP_01842	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
KOFIEAFP_01843	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
KOFIEAFP_01845	2.89e-174	-	6.3.5.11, 6.3.5.9	-	V	ko:K02224,ko:K18554	ko00860,ko01100,ko01120,map00860,map01100,map01120	br01600,ko00000,ko00001,ko01000,ko01504	Chloramphenicol phosphotransferase-like protein
KOFIEAFP_01846	9.54e-85	-	-	-	K	ko:K07343	-	ko00000	positive regulation of type IV pilus biogenesis
KOFIEAFP_01847	6.74e-225	-	-	-	CO	-	-	-	Redoxin
KOFIEAFP_01848	1.73e-123	paiA	-	-	K	-	-	-	acetyltransferase
KOFIEAFP_01849	1.54e-214	-	-	-	K	-	-	-	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
KOFIEAFP_01851	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl tRNA synthetase N terminal dom
KOFIEAFP_01854	0.0	-	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
KOFIEAFP_01855	0.0	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
KOFIEAFP_01856	2.1e-06	-	-	-	-	-	-	-	-
KOFIEAFP_01857	0.0	-	-	-	G	-	-	-	Glycosyl hydrolases family 18
KOFIEAFP_01858	0.0	-	-	-	S	ko:K07126,ko:K13582	ko04112,map04112	ko00000,ko00001	beta-lactamase activity
KOFIEAFP_01860	4.14e-279	-	6.2.1.26	-	IQ	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	AMP-binding enzyme
KOFIEAFP_01861	1.27e-70	-	-	-	K	-	-	-	ribonuclease III activity
KOFIEAFP_01862	1.09e-164	-	-	-	-	-	-	-	-
KOFIEAFP_01863	8.56e-140	nuoC	1.6.5.3	-	C	ko:K00332	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_01864	6.52e-139	nuoB	1.6.5.3	-	C	ko:K00331	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOFIEAFP_01868	5.21e-30	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
KOFIEAFP_01871	3.5e-121	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
KOFIEAFP_01872	0.0	-	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	IMP dehydrogenase / GMP reductase domain
KOFIEAFP_01873	0.0	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	GMP synthase C terminal domain
KOFIEAFP_01874	1.58e-138	-	-	-	S	-	-	-	Maltose acetyltransferase
KOFIEAFP_01875	2.62e-152	ppaX_1	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
KOFIEAFP_01876	1.41e-30	-	-	-	S	-	-	-	NYN domain
KOFIEAFP_01877	5.05e-233	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
KOFIEAFP_01878	2.14e-127	-	-	-	-	-	-	-	-
KOFIEAFP_01879	6.87e-256	-	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOFIEAFP_01881	1.15e-151	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
KOFIEAFP_01882	3.86e-76	-	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase SecG subunit
KOFIEAFP_01883	9e-65	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KOFIEAFP_01884	1.42e-219	-	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin kinase
KOFIEAFP_01885	9.36e-171	truB	5.4.99.25	-	J	ko:K03177	-	ko00000,ko01000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KOFIEAFP_01886	2.08e-241	-	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
KOFIEAFP_01888	8.85e-209	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
KOFIEAFP_01889	9.15e-244	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
KOFIEAFP_01890	7.08e-251	-	-	-	S	-	-	-	Glycosyltransferase like family 2
KOFIEAFP_01891	3.86e-235	-	-	GT9	M	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	ADP-heptose-lipopolysaccharide heptosyltransferase activity
KOFIEAFP_01892	2.26e-245	-	5.1.3.20	-	M	ko:K03274	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	3-beta hydroxysteroid dehydrogenase/isomerase family
KOFIEAFP_01893	2.74e-288	-	-	-	M	-	-	-	Glycosyltransferase like family 2
KOFIEAFP_01894	1.71e-203	-	-	-	-	-	-	-	-
KOFIEAFP_01895	3.5e-309	-	-	-	M	-	-	-	Glycosyl transferases group 1
KOFIEAFP_01896	1.05e-252	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
KOFIEAFP_01897	0.0	-	-	-	I	-	-	-	Acyltransferase family
KOFIEAFP_01898	2.8e-258	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
KOFIEAFP_01900	0.0	-	-	-	P	-	-	-	Citrate transporter
KOFIEAFP_01902	6.56e-112	-	-	-	S	ko:K08999	-	ko00000	Bifunctional nuclease
KOFIEAFP_01903	5.58e-110	-	-	-	S	-	-	-	Bacterial transferase hexapeptide (six repeats)
KOFIEAFP_01904	0.0	-	-	-	E	-	-	-	Transglutaminase-like
KOFIEAFP_01905	8.77e-158	-	-	-	C	-	-	-	Nitroreductase family
KOFIEAFP_01907	0.0	-	3.2.1.23	-	G	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
KOFIEAFP_01908	5.26e-180	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
KOFIEAFP_01909	1.69e-242	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
KOFIEAFP_01910	3.46e-290	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_01911	1.42e-315	hsrA	-	-	EGP	-	-	-	Major facilitator Superfamily
KOFIEAFP_01912	7.17e-104	yciA	-	-	I	ko:K10806	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	acyl-coa hydrolase
KOFIEAFP_01915	2.54e-206	-	-	-	IQ	-	-	-	KR domain
KOFIEAFP_01916	2.56e-243	-	-	-	M	-	-	-	Alginate lyase
KOFIEAFP_01917	1.95e-107	-	-	-	L	-	-	-	Staphylococcal nuclease homologues
KOFIEAFP_01920	3.45e-121	-	-	-	K	-	-	-	ParB domain protein nuclease
KOFIEAFP_01921	0.0	-	-	-	S	-	-	-	Phosphoadenosine phosphosulfate reductase
KOFIEAFP_01924	2.64e-267	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
KOFIEAFP_01925	1.07e-268	-	-	-	E	-	-	-	FAD dependent oxidoreductase
KOFIEAFP_01926	1.21e-210	-	-	-	S	-	-	-	Rhomboid family
KOFIEAFP_01927	0.0	-	-	-	O	ko:K07391	-	ko00000	Magnesium chelatase, subunit ChlI C-terminal
KOFIEAFP_01928	5.93e-05	-	-	-	-	-	-	-	-
KOFIEAFP_01929	0.0	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
KOFIEAFP_01930	1.32e-313	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
KOFIEAFP_01931	1.71e-264	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
KOFIEAFP_01933	8.62e-102	-	-	-	-	-	-	-	-
KOFIEAFP_01934	9.43e-235	gpsA	1.1.1.94	-	C	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
KOFIEAFP_01935	4.34e-152	-	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Glycerol-3-phosphate acyltransferase
KOFIEAFP_01936	1.02e-187	pppL	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	protein serine/threonine phosphatase activity
KOFIEAFP_01937	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
KOFIEAFP_01938	0.0	-	1.2.7.1	-	C	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KOFIEAFP_01940	1.32e-101	manC	-	-	S	-	-	-	Cupin domain
KOFIEAFP_01941	3.74e-69	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
KOFIEAFP_01942	0.0	-	-	-	G	-	-	-	Domain of unknown function (DUF4091)
KOFIEAFP_01943	1.05e-177	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
KOFIEAFP_01945	0.0	-	-	-	P	-	-	-	Cation transport protein
KOFIEAFP_01946	3.52e-161	-	-	-	P	ko:K03499	-	ko00000,ko02000	TrkA-N domain
KOFIEAFP_01947	0.0	-	3.6.4.13	-	L	ko:K03578	-	ko00000,ko01000	Oligonucleotide/oligosaccharide-binding (OB)-fold
KOFIEAFP_01948	1.18e-109	-	2.2.1.6	-	E	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	ACT domain
KOFIEAFP_01949	0.0	-	-	-	O	-	-	-	Trypsin
KOFIEAFP_01950	7.08e-272	-	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
KOFIEAFP_01951	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
KOFIEAFP_01953	5.3e-265	-	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	RibD C-terminal domain
KOFIEAFP_01954	4.01e-157	-	-	-	M	-	-	-	Bacterial transferase hexapeptide (six repeats)
KOFIEAFP_01956	1.02e-258	-	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
KOFIEAFP_01958	1.05e-252	-	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	adenosylhomocysteinase activity
KOFIEAFP_01959	0.0	-	-	-	V	-	-	-	MatE
KOFIEAFP_01960	3.05e-180	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_01961	2.63e-84	-	-	-	M	-	-	-	Lysin motif
KOFIEAFP_01962	4.37e-203	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
KOFIEAFP_01963	2.53e-266	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2219)
KOFIEAFP_01964	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
KOFIEAFP_01965	2.66e-06	-	-	-	-	-	-	-	-
KOFIEAFP_01967	0.0	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
KOFIEAFP_01968	2.4e-167	-	-	-	T	ko:K07667	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
KOFIEAFP_01970	0.0	-	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KOFIEAFP_01971	0.0	-	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KOFIEAFP_01972	6.76e-131	-	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KOFIEAFP_01973	2.5e-79	-	-	-	S	-	-	-	PFAM Cupin 2 conserved barrel domain protein
KOFIEAFP_01974	1.1e-231	-	-	-	K	-	-	-	DNA-binding transcription factor activity
KOFIEAFP_01976	0.0	-	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	C-terminal, D2-small domain, of ClpB protein
KOFIEAFP_01978	3.4e-276	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
KOFIEAFP_01979	1.35e-240	-	-	-	O	-	-	-	Trypsin-like peptidase domain
KOFIEAFP_01980	0.0	-	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Transglycosylase
KOFIEAFP_01981	3.47e-285	-	-	-	S	ko:K09760	-	ko00000	RmuC family
KOFIEAFP_01982	1.4e-171	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
KOFIEAFP_01983	1.25e-132	-	2.3.1.129	-	M	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	ko00000,ko00001,ko00002,ko01000,ko01005	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KOFIEAFP_01984	6.21e-207	-	-	-	S	-	-	-	RDD family
KOFIEAFP_01985	0.0	-	-	-	M	ko:K09808	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MacB-like periplasmic core domain
KOFIEAFP_01986	1.96e-209	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
KOFIEAFP_01987	6.5e-90	-	-	-	S	ko:K09793	-	ko00000	Protein of unknown function (DUF456)
KOFIEAFP_01988	9.7e-58	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
KOFIEAFP_01989	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
KOFIEAFP_01990	2.73e-09	-	-	-	S	-	-	-	Peptidase family M28
KOFIEAFP_01991	1.43e-248	-	-	-	I	-	-	-	alpha/beta hydrolase fold
KOFIEAFP_01992	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KOFIEAFP_01993	1.24e-186	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase (SPase) II
KOFIEAFP_01994	1.19e-152	-	-	-	S	-	-	-	Protein of unknown function (DUF1573)
KOFIEAFP_01995	3.13e-114	-	-	-	P	-	-	-	Rhodanese-like domain
KOFIEAFP_01996	1.34e-298	-	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KOFIEAFP_01997	0.0	-	-	-	S	-	-	-	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KOFIEAFP_01998	0.000231	-	2.7.11.1, 2.7.11.17	-	T	ko:K08794,ko:K13412,ko:K17530	ko04626,ko04921,ko04925,ko05145,map04626,map04921,map04925,map05145	ko00000,ko00001,ko01000,ko01001	protein serine/threonine kinase activity
KOFIEAFP_02000	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
KOFIEAFP_02001	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_02002	4.12e-100	-	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Glyoxalase-like domain
KOFIEAFP_02003	0.0	-	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Carboxyl transferase domain
KOFIEAFP_02005	1.97e-54	-	-	-	I	-	-	-	PFAM biotin lipoyl attachment domain-containing protein
KOFIEAFP_02006	0.0	-	4.1.1.3	-	C	ko:K01572	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Na+-transporting oxaloacetate decarboxylase beta subunit
KOFIEAFP_02007	1.35e-191	-	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Biotin/lipoate A/B protein ligase family
KOFIEAFP_02008	0.0	-	-	-	C	-	-	-	Acetyl-CoA hydrolase/transferase C-terminal domain
KOFIEAFP_02010	9.53e-206	-	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KOFIEAFP_02011	7.56e-271	-	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Male sterility protein
KOFIEAFP_02012	1.13e-228	-	2.7.1.11	-	G	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Phosphofructokinase
KOFIEAFP_02013	7.49e-181	-	-	-	L	ko:K10800	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	uracil-dna glycosylase
KOFIEAFP_02014	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KOFIEAFP_02015	0.0	poxB	1.2.3.3, 1.2.5.1	-	EH	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Thiamine pyrophosphate enzyme, central domain
KOFIEAFP_02019	6.38e-237	-	-	-	F	-	-	-	helicase superfamily c-terminal domain
KOFIEAFP_02020	2.96e-88	-	-	-	S	-	-	-	Domain of unknown function (DUF1837)
KOFIEAFP_02021	1.48e-67	-	-	-	S	-	-	-	Type II restriction endonuclease EcoO109I
KOFIEAFP_02022	1.93e-168	dcm	2.1.1.37	-	H	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
KOFIEAFP_02023	1.4e-27	-	-	-	K	-	-	-	Cro/C1-type HTH DNA-binding domain
KOFIEAFP_02024	5.93e-61	vsr	-	-	L	ko:K07458	-	ko00000,ko01000,ko03400	DNA mismatch endonuclease Vsr
KOFIEAFP_02025	1.05e-162	-	-	-	K	ko:K07727	-	ko00000,ko03000	addiction module antidote protein HigA
KOFIEAFP_02026	7.02e-27	-	-	-	D	-	-	-	Plasmid recombination enzyme
KOFIEAFP_02027	3.36e-40	-	-	-	L	-	-	-	Domain of unknown function (DUF4368)
KOFIEAFP_02028	0.0	-	-	-	G	-	-	-	alpha-galactosidase
KOFIEAFP_02030	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
KOFIEAFP_02031	3.93e-267	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOFIEAFP_02032	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOFIEAFP_02033	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
KOFIEAFP_02035	6.08e-178	-	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
KOFIEAFP_02037	3.59e-164	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
KOFIEAFP_02040	0.0	-	-	-	L	-	-	-	DNA restriction-modification system
KOFIEAFP_02043	3.92e-115	-	-	-	-	-	-	-	-
KOFIEAFP_02044	9e-182	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
KOFIEAFP_02046	1.34e-161	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
KOFIEAFP_02047	2.04e-258	tdh	1.1.1.103	-	E	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
KOFIEAFP_02048	0.0	-	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Carbohydrate phosphorylase
KOFIEAFP_02049	2.13e-182	-	-	-	P	ko:K10716	-	ko00000,ko02000	domain protein
KOFIEAFP_02050	1.55e-83	-	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	ArsC family
KOFIEAFP_02051	0.0	-	-	-	J	ko:K07576	-	ko00000	Beta-Casp domain
KOFIEAFP_02052	8.48e-56	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
KOFIEAFP_02053	1.6e-242	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
KOFIEAFP_02055	2.05e-28	-	-	-	-	-	-	-	-
KOFIEAFP_02056	8.07e-174	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	tRNA (Guanine-1)-methyltransferase
KOFIEAFP_02057	8.8e-239	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KOFIEAFP_02058	1.66e-87	-	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
KOFIEAFP_02059	0.0	-	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
KOFIEAFP_02060	2.54e-73	-	-	-	C	-	-	-	Nitroreductase family
KOFIEAFP_02061	7.13e-110	-	-	-	S	-	-	-	Acetyltransferase (GNAT) family
KOFIEAFP_02066	2.97e-210	-	-	-	M	-	-	-	Peptidase family M23
KOFIEAFP_02067	5.87e-228	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
KOFIEAFP_02068	4.13e-183	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
KOFIEAFP_02069	4.21e-121	-	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
KOFIEAFP_02070	4.14e-175	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate reductase, N-terminus
KOFIEAFP_02071	1.02e-203	dapA	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
KOFIEAFP_02073	0.0	-	-	-	G	-	-	-	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
KOFIEAFP_02074	0.000651	-	-	-	-	-	-	-	-
KOFIEAFP_02075	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
KOFIEAFP_02076	5.46e-189	-	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
KOFIEAFP_02078	0.0	-	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	DHHA2
KOFIEAFP_02079	1.89e-253	-	-	-	N	ko:K18353	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01504	Endonuclease Exonuclease Phosphatase
KOFIEAFP_02080	8.25e-63	-	-	-	L	ko:K09747	-	ko00000	YbaB/EbfC DNA-binding family
KOFIEAFP_02081	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KOFIEAFP_02083	4.03e-174	-	-	-	D	-	-	-	Phage-related minor tail protein
KOFIEAFP_02085	1.69e-174	-	-	-	L	ko:K03630	-	ko00000	RadC-like JAB domain
KOFIEAFP_02086	0.0	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KOFIEAFP_02087	6.12e-40	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KOFIEAFP_02088	2.79e-97	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KOFIEAFP_02089	1.67e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S9/S16
KOFIEAFP_02090	1.27e-99	-	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Predicted SPOUT methyltransferase
KOFIEAFP_02091	0.0	-	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
KOFIEAFP_02092	6.34e-183	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
KOFIEAFP_02093	1.08e-97	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
KOFIEAFP_02094	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
KOFIEAFP_02095	0.0	-	-	-	M	-	-	-	PFAM glycosyl transferase family 51
KOFIEAFP_02096	4.01e-186	-	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase family
KOFIEAFP_02097	1.93e-117	ispF	4.6.1.12	-	I	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
KOFIEAFP_02098	1.29e-181	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
KOFIEAFP_02099	1.39e-228	-	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphomannose isomerase type I
KOFIEAFP_02100	1.11e-236	-	-	-	-	-	-	-	-
KOFIEAFP_02101	4.84e-295	-	-	-	C	-	-	-	Na+/H+ antiporter family
KOFIEAFP_02102	1.03e-265	fcl	1.1.1.271	-	GM	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
KOFIEAFP_02103	6.96e-265	-	4.2.1.47	-	M	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KOFIEAFP_02104	1.8e-271	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase small chain, CPSase domain
KOFIEAFP_02105	0.0	-	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
KOFIEAFP_02106	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
KOFIEAFP_02107	0.0	-	1.4.1.13, 1.4.1.14	-	E	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	GXGXG motif
KOFIEAFP_02108	0.0	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
KOFIEAFP_02109	1.09e-59	-	-	-	S	ko:K08998	-	ko00000	Haemolytic
KOFIEAFP_02110	4.9e-76	-	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	Ribonuclease P
KOFIEAFP_02111	1.1e-34	-	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L34
KOFIEAFP_02112	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
KOFIEAFP_02113	0.0	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
KOFIEAFP_02114	0.0	-	-	-	G	-	-	-	Trehalase
KOFIEAFP_02115	1.6e-216	-	5.1.3.15	-	G	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Aldose 1-epimerase
KOFIEAFP_02116	3.45e-157	-	1.4.3.5	-	H	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
KOFIEAFP_02117	4.86e-199	-	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate phosphoribosyl transferase, N-terminal domain
KOFIEAFP_02118	3.2e-209	-	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Polyprenyl synthetase
KOFIEAFP_02119	9.55e-242	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KOFIEAFP_02121	5.5e-176	-	-	-	-	-	-	-	-
KOFIEAFP_02122	0.0	-	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase alpha chain
KOFIEAFP_02123	1.68e-219	-	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Pyridine nucleotide-disulphide oxidoreductase
KOFIEAFP_02124	2.29e-223	-	-	-	E	ko:K00612	-	ko00000,ko01000	lipolytic protein G-D-S-L family
KOFIEAFP_02125	6.61e-134	panZ	-	-	K	-	-	-	-acetyltransferase
KOFIEAFP_02131	9.48e-165	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
KOFIEAFP_02132	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
KOFIEAFP_02133	2.09e-207	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
KOFIEAFP_02134	8.59e-273	-	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	Thermophilic metalloprotease (M29)
KOFIEAFP_02135	5.35e-139	-	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KOFIEAFP_02136	3.01e-188	-	5.2.1.8	-	O	ko:K03773	-	ko00000,ko01000,ko03110	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
KOFIEAFP_02149	0.0	-	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
KOFIEAFP_02150	2.36e-130	-	-	-	D	ko:K06287	-	ko00000	Maf-like protein
KOFIEAFP_02151	2.66e-290	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KOFIEAFP_02153	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
KOFIEAFP_02154	0.0	-	-	-	GK	-	-	-	carbohydrate kinase activity
KOFIEAFP_02155	1.77e-201	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
KOFIEAFP_02156	1.21e-209	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KOFIEAFP_02157	0.0	-	-	-	I	-	-	-	Acetyltransferase (GNAT) domain
KOFIEAFP_02158	2.8e-143	-	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Cytidylate kinase
KOFIEAFP_02159	8.17e-147	-	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Phosphate acyltransferases
KOFIEAFP_02160	1.57e-259	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KOFIEAFP_02161	3.75e-121	actI	1.5.1.36	-	S	ko:K00484	ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220	ko00000,ko00001,ko01000	FMN binding
KOFIEAFP_02162	3.86e-162	rnc	3.1.26.3	-	K	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
KOFIEAFP_02163	0.0	-	-	-	P	ko:K07221	-	ko00000,ko02000	Phosphate-selective porin O and P
KOFIEAFP_02164	5.67e-257	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
KOFIEAFP_02166	2.11e-272	-	-	-	S	-	-	-	regulation of ryanodine-sensitive calcium-release channel activity
KOFIEAFP_02168	6.46e-230	-	-	-	M	-	-	-	lytic endotransglycosylase activity
KOFIEAFP_02169	3.86e-18	-	-	-	-	-	-	-	-
KOFIEAFP_02170	1.47e-178	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
KOFIEAFP_02171	4.83e-163	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Tetrapyrrole (Corrin/Porphyrin) Methylases
KOFIEAFP_02172	7.51e-116	-	-	-	S	-	-	-	Lipopolysaccharide-assembly
KOFIEAFP_02173	1.18e-170	-	-	-	S	ko:K05807	-	ko00000,ko02000	Outer membrane lipoprotein
KOFIEAFP_02174	2.88e-116	hisI	3.5.4.19	-	E	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Phosphoribosyl-AMP cyclohydrolase
KOFIEAFP_02175	2.56e-223	-	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
KOFIEAFP_02176	2e-120	-	3.2.2.28	-	L	ko:K03649	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	G/U mismatch-specific uracil-DNA glycosylase activity
KOFIEAFP_02177	1.03e-195	-	-	-	-	-	-	-	-
KOFIEAFP_02178	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
KOFIEAFP_02179	1.19e-137	-	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	Serine/threonine phosphatases, family 2C, catalytic domain
KOFIEAFP_02181	1.24e-182	-	-	-	Q	-	-	-	methyltransferase activity
KOFIEAFP_02182	0.0	-	6.3.5.1	-	H	ko:K01950	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	NAD synthase
KOFIEAFP_02183	2.28e-79	-	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
KOFIEAFP_02184	1.19e-315	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	BNR/Asp-box repeat
KOFIEAFP_02186	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
KOFIEAFP_02190	1.09e-09	-	-	-	K	-	-	-	transcriptional
KOFIEAFP_02195	4.39e-244	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
KOFIEAFP_02196	9.5e-239	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KOFIEAFP_02197	4.5e-283	-	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	FAD binding domain
KOFIEAFP_02198	6.09e-254	MA20_42350	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	Glycosyl transferase, family 2
KOFIEAFP_02199	2.89e-252	-	-	-	M	-	-	-	Glycosyl transferase, family 2
KOFIEAFP_02200	1.25e-240	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
KOFIEAFP_02202	0.0	-	-	-	S	-	-	-	polysaccharide biosynthetic process
KOFIEAFP_02203	1.41e-289	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
KOFIEAFP_02204	1.34e-282	-	-	-	M	-	-	-	Glycosyl transferases group 1
KOFIEAFP_02205	6.18e-143	-	-	-	S	-	-	-	Hexapeptide repeat of succinyl-transferase
KOFIEAFP_02206	4.96e-271	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
KOFIEAFP_02207	2.94e-184	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
KOFIEAFP_02208	4.2e-208	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KOFIEAFP_02209	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase activity
KOFIEAFP_02210	0.000513	-	-	-	-	-	-	-	-
KOFIEAFP_02211	7.45e-49	XK27_09985	-	-	S	-	-	-	Protein of unknown function (DUF1232)
KOFIEAFP_02212	1.43e-194	-	-	-	S	ko:K07051	-	ko00000	TatD related DNase
KOFIEAFP_02213	8.94e-56	-	-	-	-	-	-	-	-
KOFIEAFP_02214	4.83e-163	-	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	-
KOFIEAFP_02215	0.0	-	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
KOFIEAFP_02216	1.29e-187	-	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	2Fe-2S iron-sulfur cluster binding domain
KOFIEAFP_02217	4.34e-284	-	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KOFIEAFP_02218	4.05e-135	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KOFIEAFP_02219	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
KOFIEAFP_02220	0.0	-	-	-	T	-	-	-	5TM C-terminal transporter carbon starvation CstA
KOFIEAFP_02221	5.7e-160	-	-	-	-	-	-	-	-
KOFIEAFP_02222	0.0	-	-	-	P	-	-	-	PA14 domain
KOFIEAFP_02223	9.51e-81	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KOFIEAFP_02224	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KOFIEAFP_02225	5.58e-289	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	NusA-like KH domain
KOFIEAFP_02226	3.73e-195	-	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease/Exonuclease/phosphatase family
KOFIEAFP_02227	1.72e-144	-	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KOFIEAFP_02228	3.69e-168	-	-	-	J	-	-	-	Putative rRNA methylase
KOFIEAFP_02229	1.34e-202	-	-	-	S	-	-	-	Domain of unknown function (DUF362)
KOFIEAFP_02230	0.0	-	-	-	C	-	-	-	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein
KOFIEAFP_02231	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
KOFIEAFP_02233	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_02234	4.14e-184	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
KOFIEAFP_02235	7.33e-143	-	-	-	S	-	-	-	RNA recognition motif
KOFIEAFP_02236	0.0	-	-	-	M	-	-	-	Bacterial sugar transferase
KOFIEAFP_02237	3.1e-284	-	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Galactokinase galactose-binding signature
KOFIEAFP_02238	0.0	-	-	-	S	ko:K03307	-	ko00000	Sodium:solute symporter family
KOFIEAFP_02240	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
KOFIEAFP_02241	3.02e-227	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KOFIEAFP_02242	1.13e-271	-	-	-	M	-	-	-	Monogalactosyldiacylglycerol (MGDG) synthase
KOFIEAFP_02243	7.16e-174	coaX	2.7.1.33	-	K	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Type III pantothenate kinase
KOFIEAFP_02244	8.56e-45	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Phosphopantetheine attachment site
KOFIEAFP_02245	3.5e-132	-	-	-	-	-	-	-	-
KOFIEAFP_02246	1.67e-174	-	-	-	S	-	-	-	Lysin motif
KOFIEAFP_02247	3.07e-98	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
KOFIEAFP_02260	7.16e-115	-	-	-	S	ko:K03748	-	ko00000	DUF218 domain
KOFIEAFP_02262	3.4e-231	-	-	-	S	-	-	-	mannose-ethanolamine phosphotransferase activity
KOFIEAFP_02266	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RQC
KOFIEAFP_02268	3.68e-175	-	-	-	-	-	-	-	-
KOFIEAFP_02269	3.89e-209	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KOFIEAFP_02270	2.18e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
KOFIEAFP_02271	1.22e-288	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KOFIEAFP_02272	5.49e-206	-	-	-	S	ko:K03453	-	ko00000	Bile acid
KOFIEAFP_02275	6.39e-71	-	-	-	-	-	-	-	-
KOFIEAFP_02276	0.0	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
KOFIEAFP_02277	0.0	-	2.3.1.40, 6.2.1.20	-	IQ	ko:K05939	ko00071,ko00564,map00071,map00564	ko00000,ko00001,ko01000	AMP-binding enzyme
KOFIEAFP_02278	3.49e-45	-	-	-	T	-	-	-	pathogenesis
KOFIEAFP_02280	0.0	-	2.1.1.13	-	E	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	B12 binding domain
KOFIEAFP_02281	6.75e-171	-	-	-	S	-	-	-	Putative threonine/serine exporter
KOFIEAFP_02282	2.34e-108	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
KOFIEAFP_02284	0.0	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
KOFIEAFP_02285	2.52e-281	-	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
KOFIEAFP_02286	1.12e-116	agmK	1.8.1.8	-	O	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko03110	belongs to the thioredoxin family
KOFIEAFP_02287	1.11e-180	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
KOFIEAFP_02289	0.0	-	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
KOFIEAFP_02290	7.62e-219	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KOFIEAFP_02291	3.4e-258	-	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	endonuclease III
KOFIEAFP_02292	4.25e-144	aat	2.3.2.6	-	O	ko:K00684	-	ko00000,ko01000	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KOFIEAFP_02293	0.0	-	2.7.9.1	-	G	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Pyruvate phosphate dikinase, PEP/pyruvate binding domain
KOFIEAFP_02294	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglucose isomerase
KOFIEAFP_02295	1.15e-262	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
KOFIEAFP_02296	4.13e-174	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
KOFIEAFP_02302	8.38e-129	-	-	-	S	-	-	-	Glycosyl hydrolase 108
KOFIEAFP_02307	2.05e-06	-	-	-	L	-	-	-	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KOFIEAFP_02308	7.78e-20	-	-	-	-	-	-	-	-
KOFIEAFP_02312	1.74e-139	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
KOFIEAFP_02315	3.95e-252	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KOFIEAFP_02316	3.74e-210	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
KOFIEAFP_02317	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KOFIEAFP_02318	3.58e-199	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KOFIEAFP_02322	4.33e-161	menG	2.1.1.163, 2.1.1.201	-	Q	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	ubiE/COQ5 methyltransferase family
KOFIEAFP_02323	0.0	-	-	-	V	-	-	-	MatE
KOFIEAFP_02325	5.1e-265	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
KOFIEAFP_02326	3.71e-260	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
KOFIEAFP_02327	1.66e-248	ppiD	5.2.1.8	-	O	ko:K03769,ko:K03770,ko:K03771,ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl cis-trans isomerase activity
KOFIEAFP_02329	0.0	-	-	-	-	-	-	-	-
KOFIEAFP_02330	3.42e-180	kdsB	2.7.7.38	-	M	ko:K00979	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KOFIEAFP_02331	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
KOFIEAFP_02332	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
KOFIEAFP_02333	0.0	-	4.2.1.2	-	C	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible hydration of fumarate to (S)- malate
KOFIEAFP_02335	5.11e-106	-	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	6-pyruvoyl tetrahydropterin synthase
KOFIEAFP_02337	0.0	-	3.2.1.52	GH20	G	ko:K01207,ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko01501,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map01501,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
KOFIEAFP_02338	1.53e-302	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KOFIEAFP_02339	1.02e-228	-	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate synthetase A protein
KOFIEAFP_02340	5.01e-255	-	-	-	S	-	-	-	Putative S-adenosyl-L-methionine-dependent methyltransferase