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ORF_ID	e_value	Gene_name	EC_number	CAZy	COGs	KEGG_ko	KEGG_Pathway	BRITE	Description
CIGNAPPK_00002	0.0	-	-	-	MU	ko:K18139	ko01501,ko02024,map01501,map02024	ko00000,ko00001,ko00002,ko01504,ko02000	Outer membrane efflux protein
CIGNAPPK_00003	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIGNAPPK_00004	1.58e-282	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIGNAPPK_00005	0.0	prlC	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
CIGNAPPK_00006	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	LeuA allosteric (dimerisation) domain
CIGNAPPK_00008	6.78e-42	-	-	-	S	-	-	-	PurA ssDNA and RNA-binding protein
CIGNAPPK_00009	2.49e-255	-	-	-	D	ko:K03593	-	ko00000,ko03029,ko03036	Iron-sulfur cluster assembly protein
CIGNAPPK_00010	0.0	-	-	-	V	ko:K03327	-	ko00000,ko02000	MatE
CIGNAPPK_00011	0.0	-	-	-	V	-	-	-	T5orf172
CIGNAPPK_00012	7.07e-187	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	Eco57I restriction endonuclease
CIGNAPPK_00013	3.21e-63	-	-	-	V	-	-	-	Type II restriction enzyme, methylase subunits
CIGNAPPK_00014	6.33e-74	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CIGNAPPK_00015	0.0	-	4.1.1.3	-	C	ko:K01571	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	HMGL-like
CIGNAPPK_00016	0.0	-	-	-	I	ko:K06131	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	Phospholipase D. Active site motifs.
CIGNAPPK_00017	5.77e-208	-	2.1.1.45	-	F	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Thymidylate synthase
CIGNAPPK_00018	4.13e-114	-	1.5.1.3	-	H	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	ko00000,ko00001,ko00002,ko01000	Dihydrofolate reductase
CIGNAPPK_00019	0.0	-	-	-	V	-	-	-	AcrB/AcrD/AcrF family
CIGNAPPK_00020	4.2e-264	-	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Biotin-lipoyl like
CIGNAPPK_00021	1.69e-107	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CIGNAPPK_00023	1.53e-241	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Amidohydrolase
CIGNAPPK_00024	8.17e-159	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
CIGNAPPK_00025	4.25e-291	-	-	-	L	-	-	-	helicase superfamily c-terminal domain
CIGNAPPK_00026	1.71e-110	ruvC	3.1.22.4	-	L	ko:K01159	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIGNAPPK_00027	6.95e-122	-	-	-	-	-	-	-	-
CIGNAPPK_00028	0.0	sepA	-	-	Q	-	-	-	COG2015, Alkyl sulfatase and related hydrolases
CIGNAPPK_00029	1.82e-112	-	-	-	F	ko:K08311	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	NUDIX domain
CIGNAPPK_00030	4.91e-241	-	-	-	E	ko:K07588	-	ko00000,ko01000	ArgK protein
CIGNAPPK_00031	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_00032	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_00034	2.47e-116	gepA	-	-	K	-	-	-	Phage-associated protein
CIGNAPPK_00035	1.15e-173	thiM	2.7.1.50	-	H	ko:K00878	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CIGNAPPK_00036	3.42e-135	thiE	2.5.1.3, 2.7.1.49, 2.7.4.7, 4.1.99.17	-	H	ko:K00788,ko:K03147,ko:K14153	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
CIGNAPPK_00037	2.17e-213	-	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
CIGNAPPK_00038	7.1e-311	-	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
CIGNAPPK_00039	3.77e-102	-	-	-	K	-	-	-	Transcriptional regulator
CIGNAPPK_00040	1.37e-273	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIGNAPPK_00041	5.01e-254	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CIGNAPPK_00043	6.97e-174	-	-	-	P	ko:K10716	-	ko00000,ko02000	domain protein
CIGNAPPK_00044	0.0	htpG	-	-	O	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	Hsp90 protein
CIGNAPPK_00045	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
CIGNAPPK_00046	1.35e-284	-	-	-	P	ko:K03449	-	ko00000,ko02000	Major Facilitator Superfamily
CIGNAPPK_00047	6.99e-242	pheS	6.1.1.20	-	J	ko:K01889	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Aminoacyl tRNA synthetase class II, N-terminal domain
CIGNAPPK_00048	0.0	pheT	6.1.1.20	-	J	ko:K01890	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	B3/4 domain
CIGNAPPK_00049	4.29e-256	-	-	-	S	-	-	-	Domain of unknown function (DUF4105)
CIGNAPPK_00050	1.66e-143	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
CIGNAPPK_00051	0.0	-	4.1.99.1	-	E	ko:K01667	ko00380,map00380	ko00000,ko00001,ko01000	Beta-eliminating lyase
CIGNAPPK_00052	1.03e-34	-	-	-	KLT	-	-	-	Tyrosine-protein kinase, subgroup, catalytic domain
CIGNAPPK_00053	6.59e-227	-	-	-	S	-	-	-	Protein conserved in bacteria
CIGNAPPK_00054	5.51e-211	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIGNAPPK_00055	1.15e-159	-	3.2.2.20	-	L	ko:K01246	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Methyladenine glycosylase
CIGNAPPK_00056	8.93e-181	proC	1.5.1.2	-	E	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyrroline-5-carboxylate reductase dimerisation
CIGNAPPK_00059	1.17e-245	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
CIGNAPPK_00060	2.94e-131	-	-	-	-	-	-	-	-
CIGNAPPK_00061	0.0	-	-	-	D	-	-	-	nuclear chromosome segregation
CIGNAPPK_00062	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
CIGNAPPK_00063	0.0	-	5.4.99.2	-	I	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Methylmalonyl-CoA mutase
CIGNAPPK_00067	2.68e-226	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
CIGNAPPK_00068	3.7e-259	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
CIGNAPPK_00069	0.0	pgi	5.3.1.9	-	G	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglucose isomerase
CIGNAPPK_00070	0.0	-	2.7.9.1	-	G	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Pyruvate phosphate dikinase, PEP/pyruvate binding domain
CIGNAPPK_00071	4.25e-144	aat	2.3.2.6	-	O	ko:K00684	-	ko00000,ko01000	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CIGNAPPK_00072	5.88e-259	-	-	-	L	ko:K03575	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	endonuclease III
CIGNAPPK_00073	9.27e-220	aroE	1.1.1.25	-	E	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIGNAPPK_00074	0.0	-	1.17.4.1	-	F	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko03400	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
CIGNAPPK_00076	2.72e-181	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
CIGNAPPK_00077	1.12e-116	agmK	1.8.1.8	-	O	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko03110	belongs to the thioredoxin family
CIGNAPPK_00078	2.52e-281	-	2.7.2.4	-	E	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
CIGNAPPK_00079	0.0	-	1.1.1.3	-	E	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Homoserine dehydrogenase
CIGNAPPK_00081	2.34e-108	-	-	-	S	-	-	-	Threonine/Serine exporter, ThrE
CIGNAPPK_00082	1.66e-171	-	-	-	S	-	-	-	Putative threonine/serine exporter
CIGNAPPK_00083	0.0	-	2.1.1.13	-	E	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	B12 binding domain
CIGNAPPK_00085	5.32e-148	-	-	-	Q	-	-	-	PA14
CIGNAPPK_00088	2.85e-107	-	-	-	-	-	-	-	-
CIGNAPPK_00089	0.0	mmyX	5.3.1.12	-	F	ko:K01812,ko:K07149,ko:K16139	ko00040,ko01100,map00040,map01100	ko00000,ko00001,ko00002,ko01000,ko02000	Psort location Cytoplasmic, score
CIGNAPPK_00090	4.96e-113	ybaK	-	-	S	ko:K03976	-	ko00000,ko01000,ko03016	Cys-tRNA(Pro) hydrolase activity
CIGNAPPK_00092	7.17e-172	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	Glutamine amidotransferase class-I
CIGNAPPK_00093	7.35e-119	-	-	-	T	ko:K07005	-	ko00000	pyridoxamine 5'-phosphate
CIGNAPPK_00094	4.33e-171	-	-	-	S	-	-	-	Integral membrane protein (intg_mem_TP0381)
CIGNAPPK_00096	5.24e-268	-	-	-	C	-	-	-	NADH:flavin oxidoreductase / NADH oxidase family
CIGNAPPK_00097	2.09e-150	-	4.1.3.27	-	EH	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Peptidase C26
CIGNAPPK_00098	3.11e-248	pabB	2.6.1.85, 4.1.3.27, 4.1.3.38	-	EH	ko:K01665,ko:K03342,ko:K13503,ko:K13950	ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIGNAPPK_00099	2.44e-153	-	4.1.3.38	-	E	ko:K02619	ko00790,map00790	ko00000,ko00001,ko01000	branched-chain-amino-acid transaminase activity
CIGNAPPK_00100	1.64e-314	-	5.1.3.8	-	G	ko:K01787	ko00520,map00520	ko00000,ko00001,ko01000	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
CIGNAPPK_00101	1.38e-223	-	4.1.3.3	-	EM	ko:K01639	ko00520,map00520	ko00000,ko00001,ko01000	Dihydrodipicolinate synthetase family
CIGNAPPK_00102	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00103	1.53e-195	-	-	-	I	-	-	-	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
CIGNAPPK_00104	0.0	-	-	-	D	-	-	-	Tetratricopeptide repeat
CIGNAPPK_00105	2.26e-306	pepT	3.4.11.4	-	E	ko:K01258	-	ko00000,ko01000,ko01002	Cleaves the N-terminal amino acid of tripeptides
CIGNAPPK_00106	0.0	-	4.3.2.2	-	F	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Adenylosuccinate lyase C-terminus
CIGNAPPK_00107	1.78e-102	MA20_05485	-	-	S	-	-	-	Putative bacterial sensory transduction regulator
CIGNAPPK_00108	1.37e-249	-	-	-	M	-	-	-	HlyD family secretion protein
CIGNAPPK_00109	0.0	-	2.7.7.7	-	L	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	ko00000,ko00001,ko01000,ko03032,ko03400	Helix-hairpin-helix class 2 (Pol1 family) motifs
CIGNAPPK_00110	1.82e-125	-	2.4.2.8	-	F	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko01000	Phosphoribosyl transferase domain
CIGNAPPK_00112	6.48e-142	-	2.3.1.183	-	M	ko:K03823	ko00440,ko01130,map00440,map01130	ko00000,ko00001,ko01000	Acetyltransferase (GNAT) domain
CIGNAPPK_00113	7.56e-246	-	-	-	S	-	-	-	Imelysin
CIGNAPPK_00114	0.0	-	-	-	C	-	-	-	Di-haem oxidoreductase, putative peroxidase
CIGNAPPK_00115	2.43e-264	-	-	-	J	-	-	-	Endoribonuclease L-PSP
CIGNAPPK_00116	4.39e-219	yclN	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
CIGNAPPK_00117	1.23e-228	fatC	-	-	P	ko:K02015	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion homeostasis
CIGNAPPK_00118	1.06e-180	yclP	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ABC transporter, ATP-binding protein
CIGNAPPK_00119	2.42e-209	fatB	-	-	P	ko:K02016	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	iron ion transport
CIGNAPPK_00120	2.69e-185	ccs1	-	-	O	ko:K07399	-	ko00000	cytochrome c biogenesis protein
CIGNAPPK_00121	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
CIGNAPPK_00122	4.87e-235	-	-	-	S	-	-	-	Acyltransferase family
CIGNAPPK_00123	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
CIGNAPPK_00124	4.58e-103	-	-	-	S	-	-	-	Protein of unknown function (DUF721)
CIGNAPPK_00125	4.64e-52	-	-	-	C	-	-	-	4Fe-4S single cluster domain of Ferredoxin I
CIGNAPPK_00126	0.0	-	-	GT2	M	ko:K03820	-	ko00000,ko01000	Carbon-nitrogen hydrolase
CIGNAPPK_00127	1.56e-176	-	-	-	S	-	-	-	Phosphodiester glycosidase
CIGNAPPK_00128	3.41e-232	-	2.7.7.13	-	JM	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
CIGNAPPK_00129	0.0	fabZ	3.5.1.108, 4.2.1.59	-	IM	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
CIGNAPPK_00130	7.44e-231	-	-	-	G	-	-	-	pfkB family carbohydrate kinase
CIGNAPPK_00131	3.1e-80	crcB	-	-	D	ko:K06199	-	ko00000,ko02000	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIGNAPPK_00132	0.0	-	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	N-6 DNA Methylase
CIGNAPPK_00133	8.64e-121	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
CIGNAPPK_00134	0.0	-	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Type I restriction enzyme R protein N terminus (HSDR_N)
CIGNAPPK_00135	1.48e-275	-	1.1.1.1	-	C	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	ko00000,ko00001,ko01000	Iron-containing alcohol dehydrogenase
CIGNAPPK_00141	6.72e-210	-	-	-	L	ko:K04763	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
CIGNAPPK_00142	8.12e-271	-	2.1.1.72	-	H	ko:K07318	-	ko00000,ko01000,ko02048	PFAM D12 class N6 adenine-specific DNA methyltransferase
CIGNAPPK_00144	2.08e-240	BT0173	-	-	S	-	-	-	Psort location Cytoplasmic, score
CIGNAPPK_00145	1.06e-169	BT0174	-	-	C	ko:K04488	-	ko00000	iron-sulfur transferase activity
CIGNAPPK_00146	2.43e-201	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
CIGNAPPK_00148	8.29e-100	cysJ	1.8.1.2	-	C	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	hydroxylamine reductase activity
CIGNAPPK_00167	8.59e-76	-	-	-	S	-	-	-	Mu-like prophage FluMu protein gp28
CIGNAPPK_00171	1.98e-12	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
CIGNAPPK_00187	1.15e-72	-	2.1.1.72	-	L	ko:K00571	-	ko00000,ko01000,ko02048	DNA methylase
CIGNAPPK_00189	7.21e-261	aroC	4.2.3.5	-	E	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIGNAPPK_00190	1.33e-52	-	-	-	L	ko:K03530	-	ko00000,ko03032,ko03036,ko03400	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
CIGNAPPK_00191	4.73e-303	-	2.5.1.7	-	M	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	ko00000,ko00001,ko01000,ko01011	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
CIGNAPPK_00193	5.22e-312	aroA	2.5.1.19	-	E	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
CIGNAPPK_00194	6.33e-86	-	-	-	S	ko:K06940	-	ko00000	Putative zinc- or iron-chelating domain
CIGNAPPK_00197	5.03e-192	uppP	3.6.1.27	-	V	ko:K06153	ko00550,map00550	ko00000,ko00001,ko01000,ko01011	Bacitracin resistance protein BacA
CIGNAPPK_00198	2.6e-238	tatC	-	-	U	ko:K03118	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIGNAPPK_00199	0.0	gltX	6.1.1.17	-	J	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIGNAPPK_00200	0.0	kefA	-	-	M	ko:K05802,ko:K22051	-	ko00000,ko02000	cellular water homeostasis
CIGNAPPK_00201	1.78e-97	queF	1.7.1.13	-	S	ko:K09457	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	QueF-like protein
CIGNAPPK_00202	1.02e-159	queC	6.3.4.20	-	F	ko:K06920	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Queuosine biosynthesis protein QueC
CIGNAPPK_00203	9.88e-145	tmk	2.7.4.9	-	F	ko:K00943	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIGNAPPK_00204	0.0	-	-	-	J	-	-	-	Beta-Casp domain
CIGNAPPK_00205	1.23e-62	-	-	-	S	-	-	-	Protein of unknown function (DUF1232)
CIGNAPPK_00206	2.22e-162	-	-	-	S	-	-	-	Protein of unknown function (DUF4230)
CIGNAPPK_00207	4.25e-306	-	1.1.1.42	-	C	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	br01601,ko00000,ko00001,ko00002,ko01000	Isocitrate/isopropylmalate dehydrogenase
CIGNAPPK_00208	2.89e-273	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
CIGNAPPK_00209	2.04e-62	-	-	-	E	ko:K07032	-	ko00000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
CIGNAPPK_00211	0.0	-	-	-	C	-	-	-	Cytochrome c
CIGNAPPK_00212	7.76e-299	-	-	-	P	-	-	-	ABC-type Zn2 transport system, periplasmic component surface adhesin
CIGNAPPK_00213	3.17e-157	-	-	-	C	-	-	-	Cytochrome c
CIGNAPPK_00215	1.65e-314	-	-	-	C	ko:K00185	-	ko00000	Polysulphide reductase, NrfD
CIGNAPPK_00216	1.33e-253	-	5.4.4.2	-	HQ	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	chorismate binding enzyme
CIGNAPPK_00217	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 31
CIGNAPPK_00218	1.25e-315	-	-	-	G	-	-	-	Glycosyl transferase 4-like domain
CIGNAPPK_00219	8.59e-293	-	3.2.1.1	GH57	G	ko:K07405	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolase family 57
CIGNAPPK_00220	3.27e-129	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
CIGNAPPK_00221	7.4e-93	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
CIGNAPPK_00222	2.29e-136	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
CIGNAPPK_00223	4.54e-284	-	5.4.99.22	-	M	ko:K06178	-	ko00000,ko01000,ko03009	translation initiation factor activity
CIGNAPPK_00224	2.18e-117	-	-	-	L	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	ko00000,ko00001,ko03029,ko03032,ko03400	Single-strand binding protein family
CIGNAPPK_00225	4.11e-314	purD	6.3.4.13	-	F	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
CIGNAPPK_00226	1.12e-142	-	-	-	S	ko:K09974	-	ko00000	Domain of unknown function (DUF1287)
CIGNAPPK_00227	0.0	fhs	6.3.4.3	-	H	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Formate--tetrahydrofolate ligase
CIGNAPPK_00228	9.98e-223	-	1.1.1.169	-	H	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Ketopantoate reductase PanE/ApbA C terminal
CIGNAPPK_00229	1.65e-208	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_00230	2.82e-185	-	-	-	T	-	-	-	Calcineurin-like phosphoesterase superfamily domain
CIGNAPPK_00231	0.0	-	-	-	EP	ko:K13894	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_00232	0.0	-	-	-	P	ko:K13895	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_00233	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
CIGNAPPK_00234	2.7e-231	-	-	-	EP	ko:K02031	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
CIGNAPPK_00235	3.75e-243	-	-	-	E	ko:K02032	ko02024,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
CIGNAPPK_00236	2.2e-274	-	5.1.1.1	-	M	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIGNAPPK_00238	3.87e-208	-	-	-	EG	-	-	-	EamA-like transporter family
CIGNAPPK_00239	9.03e-283	-	-	-	Q	-	-	-	Multicopper oxidase
CIGNAPPK_00240	0.0	-	3.1.5.1	-	F	ko:K01129	ko00230,map00230	ko00000,ko00001,ko01000	Phosphohydrolase-associated domain
CIGNAPPK_00241	1.69e-232	-	-	-	O	-	-	-	Parallel beta-helix repeats
CIGNAPPK_00243	1.37e-221	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
CIGNAPPK_00245	1.07e-138	-	-	-	K	-	-	-	ECF sigma factor
CIGNAPPK_00246	4.94e-217	ytpP	2.7.1.180, 5.3.4.1	-	CO	ko:K01829,ko:K03671,ko:K03734,ko:K06196	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko01000,ko02000,ko03110	cell redox homeostasis
CIGNAPPK_00247	0.0	-	4.1.99.17	-	H	ko:K03147	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	ThiC-associated domain
CIGNAPPK_00248	0.0	copA	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
CIGNAPPK_00249	7.29e-60	csoR	-	-	S	ko:K21600	-	ko00000,ko03000	negative regulation of transcription, DNA-templated
CIGNAPPK_00250	1.45e-133	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
CIGNAPPK_00251	0.0	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	N-terminal domain of BNR-repeat neuraminidase
CIGNAPPK_00252	3.2e-121	-	-	-	-	-	-	-	-
CIGNAPPK_00253	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
CIGNAPPK_00254	0.0	fucI	5.3.1.25, 5.3.1.3	-	G	ko:K01818	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CIGNAPPK_00256	0.0	-	2.7.1.51	-	G	ko:K00879	ko00051,ko01120,map00051,map01120	ko00000,ko00001,ko01000	FGGY family of carbohydrate kinases, C-terminal domain
CIGNAPPK_00257	1.2e-200	-	-	-	G	-	-	-	Class II Aldolase and Adducin N-terminal domain
CIGNAPPK_00259	0.0	-	-	-	M	-	-	-	AsmA-like C-terminal region
CIGNAPPK_00260	2.14e-170	-	-	-	S	ko:K06911	-	ko00000	Pirin
CIGNAPPK_00262	8.36e-173	-	2.1.1.226, 2.1.1.227	-	J	ko:K06442	-	ko00000,ko01000,ko03009	FtsJ-like methyltransferase
CIGNAPPK_00265	3.34e-214	nagB	3.5.99.6	-	G	ko:K02564	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
CIGNAPPK_00266	2.73e-284	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	S-adenosylmethionine-dependent methyltransferase
CIGNAPPK_00267	4.7e-57	-	-	-	S	ko:K06960	-	ko00000	KH domain
CIGNAPPK_00268	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00269	0.0	-	2.1.1.191	-	J	ko:K06969	-	ko00000,ko01000,ko03009	RNA cap guanine-N2 methyltransferase
CIGNAPPK_00270	3.06e-216	-	1.1.1.133	-	M	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	ko00000,ko00001,ko00002,ko01000	RmlD substrate binding domain
CIGNAPPK_00271	5.51e-240	-	4.2.1.113	-	M	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Mandelate Racemase Muconate Lactonizing
CIGNAPPK_00272	0.0	-	-	-	G	-	-	-	Glycosyl hydrolase family 20, domain 2
CIGNAPPK_00274	0.0	-	-	-	V	-	-	-	Polysaccharide biosynthesis C-terminal domain
CIGNAPPK_00275	0.0	-	3.2.1.1	GH13	G	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	ko00000,ko00001,ko01000	Alpha amylase, catalytic domain
CIGNAPPK_00276	3.33e-102	-	-	-	G	-	-	-	single-species biofilm formation
CIGNAPPK_00277	7.97e-113	-	-	-	K	ko:K13640	-	ko00000,ko03000	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CIGNAPPK_00278	4.8e-128	-	-	-	S	-	-	-	Flavodoxin-like fold
CIGNAPPK_00279	1.57e-188	-	4.1.1.44	-	S	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	ko00000,ko00001,ko01000	Cupin domain
CIGNAPPK_00280	9.83e-101	-	-	-	S	-	-	-	Antibiotic biosynthesis monooxygenase
CIGNAPPK_00281	9.98e-129	-	-	-	C	-	-	-	FMN binding
CIGNAPPK_00282	3.6e-265	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
CIGNAPPK_00283	7.33e-271	-	-	-	C	-	-	-	Aldo/keto reductase family
CIGNAPPK_00284	6.7e-265	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
CIGNAPPK_00285	2.25e-206	-	-	-	S	-	-	-	Aldo/keto reductase family
CIGNAPPK_00286	2.83e-238	-	1.2.7.3	-	-	ko:K00176,ko:K07138	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	br01601,ko00000,ko00001,ko00002,ko01000	-
CIGNAPPK_00287	8.06e-301	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_00288	1.32e-140	-	-	-	M	-	-	-	polygalacturonase activity
CIGNAPPK_00290	2.32e-192	-	-	-	KT	-	-	-	Peptidase S24-like
CIGNAPPK_00291	1.73e-291	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_00295	3.8e-80	-	-	-	S	-	-	-	Bacteriophage head to tail connecting protein
CIGNAPPK_00297	5.96e-284	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
CIGNAPPK_00298	0.0	-	3.1.1.1	-	S	ko:K03928	-	ko00000,ko01000	thiolester hydrolase activity
CIGNAPPK_00299	7.26e-285	-	-	-	IQ	-	-	-	Beta-ketoacyl synthase, C-terminal domain
CIGNAPPK_00300	9.45e-261	-	2.3.1.47	-	H	ko:K00652	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_00304	0.0	aspS	6.1.1.12	-	J	ko:K01876	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIGNAPPK_00305	7.37e-311	-	6.1.1.21	-	J	ko:K01892	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Histidyl-tRNA synthetase
CIGNAPPK_00306	1.44e-175	hypB	-	-	KO	ko:K04652	-	ko00000,ko03110	CobW/HypB/UreG, nucleotide-binding domain
CIGNAPPK_00307	0.0	-	-	-	O	ko:K04656	-	ko00000	HypF finger
CIGNAPPK_00308	3.9e-50	-	-	-	O	ko:K04653	-	ko00000	HupF/HypC family
CIGNAPPK_00309	1.35e-262	-	-	-	O	ko:K04654	-	ko00000	Hydrogenase formation hypA family
CIGNAPPK_00310	6.95e-239	-	-	-	O	ko:K04655	-	ko00000	AIR synthase related protein, N-terminal domain
CIGNAPPK_00311	1.14e-279	-	-	-	S	-	-	-	COG0790 FOG TPR repeat, SEL1 subfamily
CIGNAPPK_00312	0.0	-	-	-	M	-	-	-	Glycosyl transferase 4-like domain
CIGNAPPK_00313	0.0	dnaK	-	-	O	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	MreB/Mbl protein
CIGNAPPK_00314	2.2e-61	groS	-	-	O	ko:K04078	-	ko00000,ko03029,ko03110	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIGNAPPK_00315	0.0	groL	-	-	O	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
CIGNAPPK_00316	7.54e-99	-	-	-	S	-	-	-	peptidase
CIGNAPPK_00317	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
CIGNAPPK_00321	8.04e-298	-	-	-	-	-	-	-	-
CIGNAPPK_00322	0.0	-	-	-	D	-	-	-	Chain length determinant protein
CIGNAPPK_00323	2.63e-142	-	-	-	M	-	-	-	Polysaccharide biosynthesis/export protein
CIGNAPPK_00325	1.09e-148	ruvA	3.6.4.12	-	L	ko:K03550	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
CIGNAPPK_00326	1.67e-249	-	1.2.1.12	-	G	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
CIGNAPPK_00327	6.72e-285	pgk	2.7.2.3	-	G	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Phosphoglycerate kinase
CIGNAPPK_00328	1.81e-234	-	-	-	-	-	-	-	-
CIGNAPPK_00329	0.0	-	3.2.1.20	GH31	G	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	ko00000,ko00001,ko01000	myo-inosose-2 dehydratase activity
CIGNAPPK_00330	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
CIGNAPPK_00331	0.0	-	-	-	L	-	-	-	TRCF
CIGNAPPK_00332	1.33e-295	-	-	-	-	-	-	-	-
CIGNAPPK_00333	0.0	-	-	-	G	-	-	-	Major Facilitator Superfamily
CIGNAPPK_00334	7.36e-255	-	-	-	S	-	-	-	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CIGNAPPK_00336	5.56e-214	-	3.1.3.15	-	E	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	PHP domain
CIGNAPPK_00337	5.69e-259	-	2.3.1.8	-	C	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Phosphate acetyl/butaryl transferase
CIGNAPPK_00338	4.05e-242	tilS	6.3.4.19	-	D	ko:K04075	-	ko00000,ko01000,ko03016	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
CIGNAPPK_00339	2.59e-75	-	-	-	J	ko:K02909	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L31
CIGNAPPK_00343	3.13e-99	-	-	-	MP	-	-	-	regulation of cell-substrate adhesion
CIGNAPPK_00346	0.0	-	1.1.1.22	-	M	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	ko00000,ko00001,ko00002,ko01000	UDP binding domain
CIGNAPPK_00347	1.83e-231	-	1.1.1.37	-	C	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible oxidation of malate to oxaloacetate
CIGNAPPK_00348	0.0	-	-	-	G	-	-	-	Glycogen debranching enzyme
CIGNAPPK_00349	0.0	-	-	-	M	-	-	-	NPCBM/NEW2 domain
CIGNAPPK_00350	0.0	-	-	-	M	ko:K04744	-	ko00000,ko02000	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CIGNAPPK_00351	2.94e-155	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
CIGNAPPK_00352	1.07e-192	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
CIGNAPPK_00353	5.49e-172	-	5.4.99.19	-	J	ko:K06183	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
CIGNAPPK_00354	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_00355	4.37e-124	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	adenylate kinase activity
CIGNAPPK_00356	1.52e-167	-	3.6.3.21	-	E	ko:K02028	-	ko00000,ko00002,ko01000,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
CIGNAPPK_00357	0.0	-	-	-	ET	ko:K02029,ko:K02030	-	ko00000,ko00002,ko02000	Bacterial periplasmic substrate-binding proteins
CIGNAPPK_00359	4.29e-255	argC	1.2.1.38	-	E	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Semialdehyde dehydrogenase, NAD binding domain
CIGNAPPK_00360	2.26e-306	argJ	2.3.1.1, 2.3.1.35	-	E	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CIGNAPPK_00361	1.44e-110	-	-	-	S	-	-	-	Putative zinc- or iron-chelating domain
CIGNAPPK_00362	7.7e-31	-	-	-	S	ko:K07126	-	ko00000	Sel1-like repeats.
CIGNAPPK_00364	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	ATPases associated with a variety of cellular activities
CIGNAPPK_00365	5.07e-150	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
CIGNAPPK_00366	1.14e-126	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
CIGNAPPK_00367	3e-250	-	-	-	-	-	-	-	-
CIGNAPPK_00369	1.57e-176	-	5.3.1.16	-	E	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Histidine biosynthesis protein
CIGNAPPK_00370	4.43e-61	-	-	-	S	ko:K09131	-	ko00000	DUF167
CIGNAPPK_00371	4.23e-117	grpE	-	-	O	ko:K03687	-	ko00000,ko03029,ko03110	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CIGNAPPK_00372	2.95e-263	dnaJ	-	-	O	ko:K03686	-	ko00000,ko03029,ko03110	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
CIGNAPPK_00373	2.31e-176	-	2.1.1.193	-	J	ko:K09761	-	ko00000,ko01000,ko03009	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
CIGNAPPK_00374	2.96e-242	-	3.1.3.18	-	F	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
CIGNAPPK_00375	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
CIGNAPPK_00376	1.02e-228	-	2.5.1.32, 2.5.1.99	-	I	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Squalene/phytoene synthase
CIGNAPPK_00377	0.0	-	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Peptidase S24-like
CIGNAPPK_00378	0.0	-	1.1.3.15	-	C	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	FAD linked oxidases, C-terminal domain
CIGNAPPK_00379	6.29e-151	-	-	-	-	-	-	-	-
CIGNAPPK_00380	5.09e-168	pks6	-	-	Q	-	-	-	amino acid activation for nonribosomal peptide biosynthetic process
CIGNAPPK_00381	1.76e-173	-	-	-	S	-	-	-	Protein of unknown function (DUF3485)
CIGNAPPK_00382	8.36e-230	-	-	-	C	-	-	-	Transmembrane exosortase (Exosortase_EpsH)
CIGNAPPK_00383	4.58e-220	prs	2.7.6.1	-	EF	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIGNAPPK_00384	1.24e-131	ctc	-	-	J	ko:K02897	ko03010,map03010	ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIGNAPPK_00386	1.48e-141	hisB	4.2.1.19	-	E	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Imidazoleglycerol-phosphate dehydratase
CIGNAPPK_00387	1.31e-147	hisH	-	-	E	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CIGNAPPK_00388	1.56e-60	-	-	-	J	ko:K02990	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S6
CIGNAPPK_00389	8.87e-212	-	1.1.1.262	-	H	ko:K00097	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal phosphate biosynthetic protein PdxA
CIGNAPPK_00392	6.8e-224	-	-	-	M	-	-	-	D-alanyl-D-alanine carboxypeptidase
CIGNAPPK_00393	5.43e-255	-	2.7.1.11, 2.7.1.90	-	G	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Phosphofructokinase
CIGNAPPK_00394	1.68e-220	-	-	-	L	-	-	-	Membrane
CIGNAPPK_00395	6.18e-173	zupT	-	-	P	ko:K07238	-	ko00000,ko02000	transporter
CIGNAPPK_00396	8.72e-235	-	-	-	CO	-	-	-	Protein of unknown function, DUF255
CIGNAPPK_00399	0.0	-	2.6.1.66	-	E	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_00400	2.58e-196	-	-	-	S	-	-	-	Domain of unknown function (DUF1732)
CIGNAPPK_00401	4.39e-145	-	2.7.4.8	-	F	ko:K00942	ko00230,ko01100,map00230,map01100	ko00000,ko00001,ko00002,ko01000	Guanylate kinase homologues.
CIGNAPPK_00402	0.0	-	-	-	P	-	-	-	Citrate transporter
CIGNAPPK_00403	7.58e-209	-	-	-	J	ko:K01894	-	ko00000,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), catalytic domain
CIGNAPPK_00406	1.79e-216	menA	2.5.1.74	-	H	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	UbiA prenyltransferase family
CIGNAPPK_00407	5.46e-170	-	4.2.1.10	-	E	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Type I 3-dehydroquinase
CIGNAPPK_00409	3.21e-217	-	-	-	-	-	-	-	-
CIGNAPPK_00410	3.17e-166	-	-	-	S	ko:K05810	-	ko00000,ko01000	Multi-copper polyphenol oxidoreductase laccase
CIGNAPPK_00411	7.74e-174	-	-	-	T	-	-	-	Outer membrane lipoprotein-sorting protein
CIGNAPPK_00412	2.79e-226	-	3.5.1.104	-	G	ko:K22278	-	ko00000,ko01000	Polysaccharide deacetylase
CIGNAPPK_00413	0.0	secD	-	-	U	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIGNAPPK_00415	1.55e-276	-	3.4.23.43	-	NOU	ko:K02654	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	Type IV leader peptidase family
CIGNAPPK_00416	2.38e-258	-	3.2.2.10	-	S	ko:K06966	ko00230,ko00240,map00230,map00240	ko00000,ko00001,ko01000	Possible lysine decarboxylase
CIGNAPPK_00417	2.95e-262	rpoA	2.7.7.6	-	K	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIGNAPPK_00418	4.19e-87	rplQ	-	-	J	ko:K02879	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L17
CIGNAPPK_00419	1.54e-217	-	2.3.1.39	-	I	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Acyl transferase domain
CIGNAPPK_00421	6.65e-169	-	-	-	S	-	-	-	HAD-hyrolase-like
CIGNAPPK_00422	3.06e-286	-	-	-	S	ko:K11720	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
CIGNAPPK_00423	3.63e-270	-	-	-	E	-	-	-	serine-type peptidase activity
CIGNAPPK_00424	2.03e-308	-	-	-	M	-	-	-	OmpA family
CIGNAPPK_00425	3.11e-216	-	-	-	S	-	-	-	haloacid dehalogenase-like hydrolase
CIGNAPPK_00426	0.0	-	-	-	M	-	-	-	Peptidase M60-like family
CIGNAPPK_00427	9.77e-296	-	-	-	EGP	-	-	-	Major facilitator Superfamily
CIGNAPPK_00428	0.0	-	-	-	KT	-	-	-	Sigma factor PP2C-like phosphatases
CIGNAPPK_00429	6.91e-165	-	-	-	K	ko:K03088	-	ko00000,ko03021	Sigma-70 region 2
CIGNAPPK_00430	1.93e-241	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
CIGNAPPK_00431	5.9e-270	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	site-specific DNA-methyltransferase (adenine-specific) activity
CIGNAPPK_00432	3.54e-55	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	COG0732 Restriction endonuclease S subunits
CIGNAPPK_00433	0.0	-	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CIGNAPPK_00434	1.38e-174	-	-	-	NU	ko:K02457,ko:K08084	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	protein transport across the cell outer membrane
CIGNAPPK_00435	9.06e-189	-	-	-	-	-	-	-	-
CIGNAPPK_00436	2.55e-247	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
CIGNAPPK_00437	4.87e-183	-	6.3.1.20	-	H	ko:K03800	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
CIGNAPPK_00438	4.06e-244	-	-	-	C	ko:K19265	-	ko00000,ko01000	Aldo/keto reductase family
CIGNAPPK_00439	0.0	hppA	3.6.1.1	-	C	ko:K15987	ko00190,map00190	ko00000,ko00001,ko01000	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane
CIGNAPPK_00443	0.0	-	4.1.3.27	-	EH	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	ko00000,ko00001,ko00002,ko01000	Anthranilate synthase component I, N terminal region
CIGNAPPK_00444	0.0	trpD	2.4.2.18, 4.1.3.27	-	E	ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIGNAPPK_00445	6.8e-177	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
CIGNAPPK_00446	1.7e-154	trpF	5.3.1.24	-	E	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	N-(5'phosphoribosyl)anthranilate (PRA) isomerase
CIGNAPPK_00447	3.6e-287	-	4.2.1.20	-	E	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CIGNAPPK_00448	1.5e-185	trpA	4.2.1.20	-	E	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
CIGNAPPK_00450	0.0	-	-	-	T	-	-	-	pathogenesis
CIGNAPPK_00451	2.25e-91	-	-	-	O	-	-	-	response to oxidative stress
CIGNAPPK_00452	2.76e-294	-	2.3.1.31	-	E	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	ko00000,ko00001,ko01000	alpha/beta hydrolase fold
CIGNAPPK_00453	1.08e-63	-	-	-	J	ko:K02919	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L36
CIGNAPPK_00454	0.0	-	2.3.1.241	-	M	ko:K02517	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Glycosyltransferase family 9 (heptosyltransferase)
CIGNAPPK_00455	1.28e-180	-	1.97.1.4	-	C	ko:K04069	-	ko00000,ko01000	4Fe-4S single cluster domain
CIGNAPPK_00456	0.0	-	2.3.1.54	-	C	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	ko00000,ko00001,ko01000	Pyruvate formate lyase-like
CIGNAPPK_00457	2.2e-166	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
CIGNAPPK_00458	0.0	-	-	-	EG	-	-	-	BNR repeat-like domain
CIGNAPPK_00459	0.0	legA	3.5.1.2	-	G	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	response to abiotic stimulus
CIGNAPPK_00460	5.87e-199	supH	-	-	Q	-	-	-	phosphatase activity
CIGNAPPK_00462	5.49e-85	nuoA	1.6.5.3	-	C	ko:K00330	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_00463	7.13e-276	-	-	-	G	-	-	-	Major Facilitator Superfamily
CIGNAPPK_00464	0.000175	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CIGNAPPK_00467	8.52e-37	-	-	-	K	-	-	-	sequence-specific DNA binding
CIGNAPPK_00468	2.2e-169	-	-	-	S	-	-	-	Pfam:HipA_N
CIGNAPPK_00477	4.06e-47	-	-	-	S	-	-	-	Psort location Cytoplasmic, score 8.96
CIGNAPPK_00479	1.06e-217	-	-	-	O	-	-	-	ATPase activity
CIGNAPPK_00480	0.0	-	-	-	O	-	-	-	Belongs to the peptidase S8 family
CIGNAPPK_00481	1.96e-10	-	-	-	S	-	-	-	PFAM FRG domain
CIGNAPPK_00482	2.08e-95	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
CIGNAPPK_00483	7.45e-36	-	-	-	-	-	-	-	-
CIGNAPPK_00486	7.61e-08	-	-	-	S	-	-	-	TM2 domain
CIGNAPPK_00493	3.38e-59	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
CIGNAPPK_00494	1.99e-130	-	-	-	S	-	-	-	Virulence protein RhuM family
CIGNAPPK_00495	7.06e-157	-	-	-	S	-	-	-	filamentation induced by cAMP protein Fic
CIGNAPPK_00496	9.51e-27	-	-	-	V	-	-	-	Restriction endonuclease
CIGNAPPK_00497	6.29e-41	-	-	-	S	-	-	-	von Willebrand factor type A domain
CIGNAPPK_00498	8.66e-08	-	-	-	KLT	-	-	-	Lanthionine synthetase C-like protein
CIGNAPPK_00502	0.0	uvrB	-	-	L	ko:K03702	ko03420,map03420	ko00000,ko00001,ko03400	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
CIGNAPPK_00503	2.91e-38	-	-	-	J	ko:K02916	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L35
CIGNAPPK_00504	6.39e-80	rplT	-	-	J	ko:K02887	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIGNAPPK_00505	0.0	-	-	-	M	ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	Peptidase family M50
CIGNAPPK_00508	0.0	-	-	-	L	-	-	-	UvrD/REP helicase N-terminal domain
CIGNAPPK_00509	0.0	-	-	-	L	-	-	-	PD-(D/E)XK nuclease superfamily
CIGNAPPK_00510	3.44e-208	MA20_36650	-	-	EG	-	-	-	spore germination
CIGNAPPK_00511	2.46e-71	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
CIGNAPPK_00513	3.7e-268	-	-	-	V	-	-	-	Type II restriction enzyme, methylase subunits
CIGNAPPK_00514	1.35e-260	-	-	-	L	-	-	-	Type III restriction enzyme res subunit
CIGNAPPK_00515	1.45e-47	-	-	-	P	-	-	-	T5orf172
CIGNAPPK_00516	0.0	-	-	-	S	-	-	-	Alpha-2-macroglobulin family
CIGNAPPK_00517	2.08e-284	-	-	-	C	-	-	-	Iron-containing alcohol dehydrogenase
CIGNAPPK_00519	2.28e-120	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	6-O-methylguanine DNA methyltransferase, DNA binding domain
CIGNAPPK_00522	2.96e-212	-	-	-	-	-	-	-	-
CIGNAPPK_00523	5.41e-150	-	-	-	O	-	-	-	Glycoprotease family
CIGNAPPK_00524	2.89e-272	-	2.3.3.1	-	C	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Citrate synthase, C-terminal domain
CIGNAPPK_00526	3.86e-112	-	2.1.1.207	-	J	ko:K03216	-	ko00000,ko01000,ko03016	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily
CIGNAPPK_00527	4.12e-139	-	-	-	L	-	-	-	RNase_H superfamily
CIGNAPPK_00529	6.68e-103	smpB	-	-	O	ko:K03664	-	ko00000	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
CIGNAPPK_00530	4.3e-44	-	2.7.7.6	-	K	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	RNA polymerase activity
CIGNAPPK_00531	3.51e-136	-	5.4.99.20	-	J	ko:K06181	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
CIGNAPPK_00532	2.16e-188	-	-	-	-	-	-	-	-
CIGNAPPK_00533	1.3e-104	-	2.7.4.6	-	F	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	ko00000,ko00001,ko00002,ko01000,ko04131	NDK
CIGNAPPK_00534	1.36e-207	-	-	-	S	-	-	-	Glycosyltransferase like family 2
CIGNAPPK_00535	4.12e-225	-	-	-	M	-	-	-	Glycosyl transferase family 2
CIGNAPPK_00537	7.26e-285	-	-	-	NU	ko:K02653	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein F
CIGNAPPK_00538	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II secretion system (T2SS), protein E, N-terminal domain
CIGNAPPK_00539	0.0	-	-	-	NU	ko:K02652	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
CIGNAPPK_00540	5.14e-245	-	-	-	J	-	-	-	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIGNAPPK_00541	8.12e-110	-	-	-	S	-	-	-	Control of competence regulator ComK, YlbF/YmcA
CIGNAPPK_00542	1.1e-280	-	2.6.1.1	-	E	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
CIGNAPPK_00543	0.0	murJ	-	-	S	ko:K03980	-	ko00000,ko01011,ko02000	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
CIGNAPPK_00544	1.26e-271	-	-	-	IM	-	-	-	Cytidylyltransferase-like
CIGNAPPK_00545	1.74e-157	-	1.15.1.1	-	P	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	ko00000,ko00001,ko01000	Iron/manganese superoxide dismutases, alpha-hairpin domain
CIGNAPPK_00546	0.0	-	-	-	S	-	-	-	Glycosyl hydrolase-like 10
CIGNAPPK_00547	2.28e-170	-	-	-	S	ko:K06898	-	ko00000	AIR carboxylase
CIGNAPPK_00548	8.38e-192	-	-	-	L	ko:K06864	-	ko00000	tRNA processing
CIGNAPPK_00549	2.37e-291	larC	4.99.1.12	-	S	ko:K09121	-	ko00000,ko01000	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CIGNAPPK_00550	1.07e-238	-	2.5.1.90	-	H	ko:K02523	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Polyprenyl synthetase
CIGNAPPK_00551	0.0	-	-	-	E	ko:K03305	-	ko00000	POT family
CIGNAPPK_00552	0.0	-	5.2.1.8	-	O	ko:K03770	-	ko00000,ko01000,ko03110	PPIC-type PPIASE domain
CIGNAPPK_00553	2.39e-126	-	-	-	S	-	-	-	Pfam:DUF59
CIGNAPPK_00554	2.59e-107	-	-	-	-	-	-	-	-
CIGNAPPK_00556	3.12e-219	-	-	-	E	-	-	-	Domain of unknown function (DUF3472)
CIGNAPPK_00557	0.0	nuoN	1.6.5.3	-	C	ko:K00343	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_00558	0.0	-	1.6.5.3	-	C	ko:K00342	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Proton-conducting membrane transporter
CIGNAPPK_00559	0.0	-	1.6.5.3	-	CP	ko:K00341	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
CIGNAPPK_00560	6.01e-61	nuoK	1.6.5.3	-	C	ko:K00340	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_00561	7.62e-157	-	1.6.5.3	-	C	ko:K00339	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone/plastoquinone oxidoreductase chain 6
CIGNAPPK_00562	1.8e-124	nuoI	1.6.5.3	-	C	ko:K00338	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_00563	1.04e-309	nuoH	1.6.5.3	-	C	ko:K00337	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIGNAPPK_00564	0.0	-	1.6.5.3	-	C	ko:K00336	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
CIGNAPPK_00565	0.0	-	1.6.5.3	-	C	ko:K00335	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
CIGNAPPK_00566	2.88e-142	-	1.6.5.3	-	C	ko:K00334	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	Thioredoxin-like [2Fe-2S] ferredoxin
CIGNAPPK_00567	4.39e-307	nuoD	1.6.5.3	-	C	ko:K00333	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_00569	0.0	-	-	-	G	-	-	-	Polysaccharide deacetylase
CIGNAPPK_00570	0.0	-	-	-	P	-	-	-	Putative Na+/H+ antiporter
CIGNAPPK_00571	4.37e-141	-	2.5.1.9	-	H	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Lumazine binding domain
CIGNAPPK_00572	7.24e-205	-	-	-	J	ko:K02687	-	ko00000,ko01000,ko03009	Ribosomal protein L11 methyltransferase (PrmA)
CIGNAPPK_00573	0.0	pmp21	-	-	T	-	-	-	pathogenesis
CIGNAPPK_00574	0.0	-	2.4.1.25	GH77	G	ko:K00705	ko00500,ko01100,map00500,map01100	ko00000,ko00001,ko01000	4-alpha-glucanotransferase
CIGNAPPK_00576	0.0	-	2.8.4.4	-	J	ko:K14441	-	ko00000,ko01000,ko03009	Uncharacterized protein family UPF0004
CIGNAPPK_00577	0.0	-	-	-	-	ko:K07403	-	ko00000	-
CIGNAPPK_00578	0.0	dnaG	-	-	L	ko:K02316	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
CIGNAPPK_00579	0.0	sigA	-	-	K	ko:K03086	-	ko00000,ko03021	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
CIGNAPPK_00580	3.72e-187	-	3.4.13.22	-	M	ko:K08641	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	D-ala-D-ala dipeptidase
CIGNAPPK_00583	0.0	-	-	-	E	-	-	-	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIGNAPPK_00584	0.0	-	3.4.21.102	-	M	ko:K03797	-	ko00000,ko01000,ko01002	tail specific protease
CIGNAPPK_00585	1.9e-214	-	2.7.7.41	-	S	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	ko00000,ko00001,ko00002,ko01000	Cytidylyltransferase family
CIGNAPPK_00586	0.0	-	3.6.4.13	-	L	ko:K03579	-	ko00000,ko01000	ATP-dependent helicase C-terminal
CIGNAPPK_00587	0.0	-	-	-	P	ko:K03306	-	ko00000	phosphate transporter
CIGNAPPK_00588	2.39e-311	-	-	-	O	-	-	-	peroxiredoxin activity
CIGNAPPK_00589	0.0	-	2.7.7.19	-	J	ko:K00970	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	Poly A polymerase head domain
CIGNAPPK_00590	0.0	-	-	-	G	-	-	-	Alpha amylase, catalytic domain
CIGNAPPK_00591	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
CIGNAPPK_00592	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00593	7.21e-183	-	-	-	S	ko:K09778	-	ko00000	Domain of unknown function (DUF374)
CIGNAPPK_00594	7.21e-203	folD	1.5.1.5, 3.5.4.9	-	H	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIGNAPPK_00595	2.91e-182	-	1.3.1.10, 1.3.1.9	-	I	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Enoyl-(Acyl carrier protein) reductase
CIGNAPPK_00596	1.3e-202	-	-	-	I	-	-	-	Diacylglycerol kinase catalytic domain
CIGNAPPK_00597	1.7e-284	-	-	-	E	-	-	-	Transglutaminase-like superfamily
CIGNAPPK_00598	3.54e-260	-	-	-	J	ko:K05541	-	ko00000,ko01000,ko03016	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIGNAPPK_00599	1.31e-289	-	1.17.7.4	-	IM	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	LytB protein
CIGNAPPK_00601	2.34e-43	rpsT	-	-	J	ko:K02968	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S20
CIGNAPPK_00602	1.16e-141	-	-	-	S	-	-	-	Haloacid dehalogenase-like hydrolase
CIGNAPPK_00603	0.0	-	2.2.1.6	-	EH	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Thiamine pyrophosphate enzyme, central domain
CIGNAPPK_00605	0.0	-	-	-	L	-	-	-	Protein of unknown function (DUF1524)
CIGNAPPK_00607	2.57e-220	-	4.1.1.65	-	I	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Phosphatidylserine decarboxylase
CIGNAPPK_00608	3.85e-152	-	5.1.3.1	-	G	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Ribulose-phosphate 3 epimerase family
CIGNAPPK_00609	0.0	leuS	6.1.1.4	-	J	ko:K01869	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Leucyl-tRNA synthetase, Domain 2
CIGNAPPK_00610	0.0	-	-	-	P	-	-	-	Sulfatase
CIGNAPPK_00612	1.75e-299	-	4.1.1.96	-	E	ko:K13747	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Pyridoxal-dependent decarboxylase, C-terminal sheet domain
CIGNAPPK_00613	0.0	-	4.1.1.19	-	E	ko:K01585	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
CIGNAPPK_00614	1.93e-267	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CIGNAPPK_00615	2.65e-161	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 2 family
CIGNAPPK_00616	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
CIGNAPPK_00617	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
CIGNAPPK_00618	0.0	rarA	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
CIGNAPPK_00619	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_00621	9.49e-302	-	2.7.1.11, 2.7.1.90	-	H	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
CIGNAPPK_00622	1.15e-219	-	-	-	M	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
CIGNAPPK_00623	2.18e-269	-	-	-	K	-	-	-	Periplasmic binding protein-like domain
CIGNAPPK_00627	6.18e-125	cobU	2.7.1.156, 2.7.7.62, 6.3.5.10	-	H	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	cobinamide kinase activity
CIGNAPPK_00628	2.35e-207	-	-	-	G	-	-	-	myo-inosose-2 dehydratase activity
CIGNAPPK_00629	6.86e-174	cobS	2.7.8.26	-	H	ko:K02233	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CIGNAPPK_00630	2.08e-241	cobT	2.4.2.21	-	H	ko:K00768	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIGNAPPK_00631	1.11e-237	cobD	6.3.1.10	-	H	ko:K02227	ko00860,ko01100,map00860,map01100	ko00000,ko00001,ko00002,ko01000	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIGNAPPK_00632	0.0	cobQ	-	-	H	-	-	-	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
CIGNAPPK_00633	0.0	-	-	-	H	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
CIGNAPPK_00634	0.0	-	-	-	E	ko:K13893	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
CIGNAPPK_00635	0.0	-	3.2.1.23	-	G	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
CIGNAPPK_00636	6.65e-160	-	-	-	M	ko:K16079	-	ko00000,ko02000	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CIGNAPPK_00637	2.37e-314	-	3.5.4.28, 3.5.4.31	-	F	ko:K12960	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Amidohydrolase family
CIGNAPPK_00638	0.0	-	1.8.1.4	-	C	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
CIGNAPPK_00639	5.34e-136	dam	2.1.1.72	-	L	ko:K06223	ko03430,map03430	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	D12 class N6 adenine-specific DNA methyltransferase
CIGNAPPK_00640	8.25e-198	-	-	-	-	-	-	-	-
CIGNAPPK_00642	6.52e-233	-	2.3.1.61	-	C	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
CIGNAPPK_00643	0.0	-	1.2.4.2	-	C	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoglutarate dehydrogenase C-terminal
CIGNAPPK_00644	5.15e-246	-	1.10.3.14	-	C	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit II
CIGNAPPK_00645	0.0	-	1.10.3.14	-	C	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	ko00000,ko00001,ko00002,ko01000	Cytochrome bd terminal oxidase subunit I
CIGNAPPK_00646	2.7e-113	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_00647	2.34e-107	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
CIGNAPPK_00648	0.0	-	-	-	T	-	-	-	Chase2 domain
CIGNAPPK_00649	4.33e-235	-	2.7.1.221	-	S	ko:K07102	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko01000	Phosphotransferase enzyme family
CIGNAPPK_00650	1.25e-307	-	4.2.1.20	-	E	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CIGNAPPK_00651	4.98e-92	-	-	-	K	-	-	-	helix_turn_helix multiple antibiotic resistance protein
CIGNAPPK_00653	1.23e-112	-	1.16.3.2	-	P	ko:K02217	-	ko00000,ko01000	Ferritin-like domain
CIGNAPPK_00654	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00655	3.15e-103	-	-	-	J	-	-	-	YjgF/chorismate_mutase-like, putative endoribonuclease
CIGNAPPK_00657	7.16e-115	-	-	-	S	ko:K03748	-	ko00000	DUF218 domain
CIGNAPPK_00659	3.4e-231	-	-	-	S	-	-	-	mannose-ethanolamine phosphotransferase activity
CIGNAPPK_00663	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RQC
CIGNAPPK_00665	1.52e-175	-	-	-	-	-	-	-	-
CIGNAPPK_00666	3.89e-209	sucD	6.2.1.5	-	C	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CIGNAPPK_00667	2.18e-269	sucC	6.2.1.5	-	C	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
CIGNAPPK_00668	2.1e-289	hisD	1.1.1.23	-	E	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CIGNAPPK_00669	5.49e-206	-	-	-	S	ko:K03453	-	ko00000	Bile acid
CIGNAPPK_00672	6.39e-71	-	-	-	-	-	-	-	-
CIGNAPPK_00673	0.0	xseA	3.1.11.6	-	L	ko:K03601	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
CIGNAPPK_00674	0.0	-	2.3.1.40, 6.2.1.20	-	IQ	ko:K05939	ko00071,ko00564,map00071,map00564	ko00000,ko00001,ko01000	AMP-binding enzyme
CIGNAPPK_00685	0.0	-	4.3.1.19	-	E	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
CIGNAPPK_00686	1.37e-129	-	-	-	D	ko:K06287	-	ko00000	Maf-like protein
CIGNAPPK_00687	2.66e-290	hflX	-	-	S	ko:K03665	-	ko00000,ko03009	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIGNAPPK_00689	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
CIGNAPPK_00690	0.0	-	-	-	GK	-	-	-	carbohydrate kinase activity
CIGNAPPK_00691	4.34e-202	-	-	-	S	ko:K07052	-	ko00000	CAAX protease self-immunity
CIGNAPPK_00692	4.91e-209	thiL	2.7.4.16	-	H	ko:K00946	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIGNAPPK_00693	0.0	-	-	-	I	-	-	-	Acetyltransferase (GNAT) domain
CIGNAPPK_00694	2.8e-143	-	2.7.4.25	-	F	ko:K00945	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Cytidylate kinase
CIGNAPPK_00695	8.17e-147	-	2.3.1.51	-	I	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Phosphate acyltransferases
CIGNAPPK_00696	1.57e-259	recF	-	-	L	ko:K03629	ko03440,map03440	ko00000,ko00001,ko03400	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIGNAPPK_00697	3.15e-121	actI	1.5.1.36	-	S	ko:K00484	ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220	ko00000,ko00001,ko01000	FMN binding
CIGNAPPK_00698	6.03e-32	-	-	-	V	-	-	-	Abortive
CIGNAPPK_00699	2.4e-162	rnc	3.1.26.3	-	K	ko:K03685	ko03008,ko05205,map03008,map05205	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
CIGNAPPK_00700	0.0	-	-	-	P	ko:K07221	-	ko00000,ko02000	Phosphate-selective porin O and P
CIGNAPPK_00701	2.72e-18	-	-	-	-	-	-	-	-
CIGNAPPK_00702	3.77e-181	-	-	-	S	-	-	-	Endonuclease/Exonuclease/phosphatase family
CIGNAPPK_00703	1.19e-163	rsmI	2.1.1.198	-	H	ko:K07056	-	ko00000,ko01000,ko03009	Tetrapyrrole (Corrin/Porphyrin) Methylases
CIGNAPPK_00704	1.25e-114	-	-	-	S	-	-	-	Lipopolysaccharide-assembly
CIGNAPPK_00705	1.67e-170	-	-	-	S	ko:K05807	-	ko00000,ko02000	Outer membrane lipoprotein
CIGNAPPK_00706	2.88e-116	hisI	3.5.4.19	-	E	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Phosphoribosyl-AMP cyclohydrolase
CIGNAPPK_00707	6.3e-224	-	2.7.7.7	-	L	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
CIGNAPPK_00708	1.41e-120	-	3.2.2.28	-	L	ko:K03649	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	G/U mismatch-specific uracil-DNA glycosylase activity
CIGNAPPK_00709	1.51e-194	-	-	-	-	-	-	-	-
CIGNAPPK_00710	0.0	carB	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CIGNAPPK_00711	1.28e-136	-	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	Serine/threonine phosphatases, family 2C, catalytic domain
CIGNAPPK_00713	4.33e-183	-	-	-	Q	-	-	-	methyltransferase activity
CIGNAPPK_00714	0.0	-	6.3.5.1	-	H	ko:K01950	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	NAD synthase
CIGNAPPK_00715	2.28e-79	-	-	-	P	ko:K11741	-	ko00000,ko02000	Small Multidrug Resistance protein
CIGNAPPK_00716	6.85e-315	-	3.2.1.18	GH33	G	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	ko00000,ko00001,ko01000,ko02042	BNR/Asp-box repeat
CIGNAPPK_00717	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
CIGNAPPK_00719	1.09e-09	-	-	-	K	-	-	-	transcriptional
CIGNAPPK_00722	3.09e-51	vsr	-	-	L	ko:K07458	-	ko00000,ko01000,ko03400	May nick specific sequences that contain T G mispairs resulting from m5C-deamination
CIGNAPPK_00723	2.38e-18	-	-	-	S	-	-	-	Protein of unknown function DUF262
CIGNAPPK_00725	4.51e-122	-	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	DNA (cytosine-5-)-methyltransferase activity
CIGNAPPK_00727	5.47e-243	ruvB	3.6.4.12	-	L	ko:K03551	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
CIGNAPPK_00728	9.5e-239	fabH	2.3.1.180	-	I	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIGNAPPK_00729	5.25e-282	-	1.8.1.2	-	P	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	FAD binding domain
CIGNAPPK_00730	1.63e-210	MA20_42350	2.7.8.12	-	M	ko:K09809	-	ko00000,ko01000	Glycosyl transferase, family 2
CIGNAPPK_00731	2.66e-248	-	-	-	M	-	-	-	Glycosyl transferase, family 2
CIGNAPPK_00732	1.78e-240	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
CIGNAPPK_00734	0.0	-	-	-	S	-	-	-	polysaccharide biosynthetic process
CIGNAPPK_00735	5.65e-283	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
CIGNAPPK_00736	4.02e-284	-	-	-	M	-	-	-	Glycosyl transferases group 1
CIGNAPPK_00737	3.73e-144	-	-	-	S	-	-	-	Hexapeptide repeat of succinyl-transferase
CIGNAPPK_00738	1.04e-272	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_00739	2.94e-184	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
CIGNAPPK_00740	1.47e-208	miaA	2.5.1.75	-	J	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	ko00000,ko00001,ko01000,ko01006,ko03016	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIGNAPPK_00741	0.0	-	-	-	M	-	-	-	4-amino-4-deoxy-L-arabinose transferase activity
CIGNAPPK_00742	2.72e-263	mnmA	2.8.1.13	-	J	ko:K00566	ko04122,map04122	ko00000,ko00001,ko01000,ko03016	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
CIGNAPPK_00743	2.81e-314	mnmE	-	-	J	ko:K03650	-	ko00000,ko01000,ko03016	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIGNAPPK_00744	3.95e-13	-	-	-	S	-	-	-	Mac 1
CIGNAPPK_00745	2.82e-154	-	-	-	S	-	-	-	UPF0126 domain
CIGNAPPK_00746	5.27e-189	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
CIGNAPPK_00747	4.54e-105	-	-	-	K	ko:K03925	-	ko00000	Belongs to the MraZ family
CIGNAPPK_00748	0.0	rsmH	2.1.1.199	-	M	ko:K03438	-	ko00000,ko01000,ko03009	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
CIGNAPPK_00750	0.0	-	3.4.16.4	-	M	ko:K03587	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011,ko03036	Penicillin-binding Protein dimerisation domain
CIGNAPPK_00751	0.0	murE	6.3.2.13	-	M	ko:K01928	ko00300,ko00550,map00300,map00550	ko00000,ko00001,ko01000,ko01011	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIGNAPPK_00752	0.0	-	6.3.2.10	-	M	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Mur ligase middle domain
CIGNAPPK_00753	1.99e-261	mraY	2.7.8.13	-	M	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIGNAPPK_00754	1.45e-314	murD	6.3.2.9	-	M	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIGNAPPK_00755	1e-160	mltD	-	CBM50	M	ko:K08307,ko:K12204,ko:K19224	-	ko00000,ko01000,ko01002,ko01011,ko02044	LysM domain
CIGNAPPK_00756	1.33e-277	-	-	-	D	ko:K03588	ko04112,map04112	ko00000,ko00001,ko02000,ko03036	Cell cycle protein
CIGNAPPK_00757	5.55e-267	-	2.4.1.227	GT28	M	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	ko00000,ko00001,ko01000,ko01011	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIGNAPPK_00758	0.0	murB	-	-	M	-	-	-	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain
CIGNAPPK_00759	1.44e-228	ddl	6.3.2.4	-	M	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	D-ala D-ala ligase N-terminus
CIGNAPPK_00760	7.32e-216	-	-	-	M	ko:K03589	ko04112,map04112	ko00000,ko00001,ko03036	POTRA domain, FtsQ-type
CIGNAPPK_00761	1.15e-238	recA	-	-	L	ko:K03553	ko03440,map03440	ko00000,ko00001,ko00002,ko03400	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CIGNAPPK_00762	1.92e-238	-	3.5.1.28	-	M	ko:K01448	ko01503,map01503	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	Ami_3
CIGNAPPK_00763	2.91e-140	-	2.3.1.181	-	H	ko:K03801	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Biotin/lipoate A/B protein ligase family
CIGNAPPK_00764	0.0	-	4.2.1.33, 4.2.1.35	-	E	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase family (aconitate hydratase)
CIGNAPPK_00765	1.53e-146	-	4.2.1.33, 4.2.1.35	-	E	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
CIGNAPPK_00766	2.89e-273	-	-	-	-	-	-	-	-
CIGNAPPK_00767	0.0	-	-	-	O	-	-	-	Trypsin
CIGNAPPK_00768	0.0	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
CIGNAPPK_00769	3.72e-283	-	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	3-dehydroquinate synthase
CIGNAPPK_00771	3.1e-173	-	-	-	E	-	-	-	ATPases associated with a variety of cellular activities
CIGNAPPK_00772	2.05e-198	tsf	-	-	J	ko:K02357	-	ko00000,ko03012,ko03029	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIGNAPPK_00773	5.88e-163	rpsB	-	-	J	ko:K02967	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S2
CIGNAPPK_00774	1.86e-171	cbiX	4.99.1.3	-	S	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	ko00000,ko00001,ko01000	sirohydrochlorin cobaltochelatase activity
CIGNAPPK_00775	2.72e-197	-	2.5.1.55	-	M	ko:K01627	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	DAHP synthetase I family
CIGNAPPK_00778	6.31e-171	-	-	-	S	ko:K06861	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_00779	6.55e-221	-	-	-	E	-	-	-	Phosphoserine phosphatase
CIGNAPPK_00780	0.0	-	6.3.2.45	-	M	ko:K02558	-	ko00000,ko01000	Mur ligase family, catalytic domain
CIGNAPPK_00781	1.8e-305	-	-	-	M	-	-	-	OmpA family
CIGNAPPK_00782	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
CIGNAPPK_00783	2.27e-86	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
CIGNAPPK_00784	9.58e-117	ywrF	-	-	S	-	-	-	FMN binding
CIGNAPPK_00785	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
CIGNAPPK_00786	0.0	-	-	-	T	-	-	-	pathogenesis
CIGNAPPK_00788	0.0	asnS	6.1.1.22	-	J	ko:K01893	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
CIGNAPPK_00789	7.81e-316	-	-	-	-	-	-	-	-
CIGNAPPK_00790	5.12e-71	-	-	-	O	ko:K03671	ko04621,ko05418,map04621,map05418	ko00000,ko00001,ko03110	Thioredoxin-like domain
CIGNAPPK_00792	5.24e-159	-	-	-	S	-	-	-	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIGNAPPK_00793	1.31e-255	-	-	-	M	ko:K02022	-	ko00000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIGNAPPK_00794	8.42e-302	-	4.2.1.129, 5.4.99.17, 5.5.1.16	-	I	ko:K06045,ko:K17811	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
CIGNAPPK_00795	0.0	-	-	-	I	-	-	-	PFAM Prenyltransferase squalene oxidase
CIGNAPPK_00796	2.98e-295	-	3.2.1.23	-	M	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
CIGNAPPK_00797	5.69e-287	-	3.2.1.23	-	M	ko:K12308	ko00052,map00052	ko00000,ko00001,ko01000	Belongs to the glycosyl hydrolase 43 family
CIGNAPPK_00800	9.2e-214	-	-	-	K	-	-	-	LysR substrate binding domain
CIGNAPPK_00801	5.45e-234	-	-	-	S	-	-	-	Conserved hypothetical protein 698
CIGNAPPK_00802	2.12e-251	-	-	-	E	-	-	-	Aminotransferase class-V
CIGNAPPK_00803	2.2e-313	-	-	-	S	-	-	-	Protein of unknown function (DUF1015)
CIGNAPPK_00804	0.0	-	1.1.1.399, 1.1.1.95	-	EH	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
CIGNAPPK_00805	4e-190	-	2.7.13.3	-	Q	ko:K07777	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Transposase
CIGNAPPK_00806	6.66e-167	-	4.3.99.3	-	O	ko:K10026	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko01000,ko03016	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
CIGNAPPK_00807	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIGNAPPK_00808	5.84e-173	-	-	-	K	-	-	-	Transcriptional regulator
CIGNAPPK_00809	0.0	-	-	-	P	-	-	-	Dimerisation domain of Zinc Transporter
CIGNAPPK_00810	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
CIGNAPPK_00812	1.36e-242	queA	2.4.99.17	-	J	ko:K07568	-	ko00000,ko01000,ko03016	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CIGNAPPK_00813	1.79e-201	-	-	-	S	-	-	-	SigmaW regulon antibacterial
CIGNAPPK_00815	2.02e-173	-	2.8.1.10	-	H	ko:K03149	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Thiazole biosynthesis protein ThiG
CIGNAPPK_00816	1.14e-294	-	-	-	E	-	-	-	Amino acid permease
CIGNAPPK_00817	1.1e-153	gph	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
CIGNAPPK_00818	6.62e-257	-	-	-	S	ko:K11744	-	ko00000	AI-2E family transporter
CIGNAPPK_00819	2.39e-314	-	4.1.1.20	-	E	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase, pyridoxal binding domain
CIGNAPPK_00820	1.32e-235	-	4.1.2.13	-	G	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Fructose-bisphosphate aldolase class-II
CIGNAPPK_00821	0.0	-	-	-	T	ko:K06207	-	ko00000	Elongation factor G C-terminus
CIGNAPPK_00822	8.55e-214	-	2.6.1.42	-	E	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIGNAPPK_00823	2.03e-222	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
CIGNAPPK_00824	4.46e-127	-	2.1.1.63	-	L	ko:K00567	-	ko00000,ko01000,ko03400	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIGNAPPK_00825	6.46e-137	-	-	-	T	-	-	-	histone H2A K63-linked ubiquitination
CIGNAPPK_00827	3.23e-253	obg	-	-	S	ko:K03979	-	ko00000,ko01000,ko03009	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIGNAPPK_00828	2.84e-286	-	-	-	S	-	-	-	Phosphotransferase enzyme family
CIGNAPPK_00829	3.81e-255	-	6.3.2.4	-	F	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	ko00000,ko00001,ko01000,ko01011	Belongs to the D-alanine--D-alanine ligase family
CIGNAPPK_00830	5.09e-267	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
CIGNAPPK_00832	3.69e-75	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_00835	0.0	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_00836	1.38e-95	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_00837	0.0	-	-	-	E	ko:K20265	ko02024,map02024	ko00000,ko00001,ko02000	amino acid
CIGNAPPK_00838	1.43e-220	-	3.5.1.2	-	E	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	ko00000,ko00001,ko01000	Glutaminase
CIGNAPPK_00839	2.43e-95	-	-	-	K	-	-	-	-acetyltransferase
CIGNAPPK_00840	5.82e-308	-	-	-	E	ko:K03310	-	ko00000	Sodium:alanine symporter family
CIGNAPPK_00842	3.95e-252	prfA	-	-	J	ko:K02835	-	ko00000,ko03012	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIGNAPPK_00843	7.03e-215	prmC	2.1.1.297	-	J	ko:K02493	-	ko00000,ko01000,ko03012	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
CIGNAPPK_00844	0.0	priA	-	-	L	ko:K04066	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIGNAPPK_00845	1.25e-199	dapF	5.1.1.7	-	E	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIGNAPPK_00849	4.33e-161	menG	2.1.1.163, 2.1.1.201	-	Q	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	ubiE/COQ5 methyltransferase family
CIGNAPPK_00850	0.0	-	-	-	V	-	-	-	MatE
CIGNAPPK_00852	0.0	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
CIGNAPPK_00853	5.28e-262	rlmN	2.1.1.192	-	J	ko:K06941	-	ko00000,ko01000,ko03009	Elongator protein 3, MiaB family, Radical SAM
CIGNAPPK_00854	1.1e-197	-	-	-	U	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SRP54-type protein, GTPase domain
CIGNAPPK_00855	2.33e-205	nusB	-	-	K	ko:K03625	-	ko00000,ko03009,ko03021	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIGNAPPK_00856	7.32e-105	ribH	2.5.1.78	-	H	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
CIGNAPPK_00857	9.59e-288	-	3.5.4.25, 4.1.99.12	-	H	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	ko00000,ko00001,ko00002,ko01000	GTP cyclohydrolase II
CIGNAPPK_00858	0.0	glnS	6.1.1.18	-	J	ko:K01886	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (E and Q), anti-codon binding domain
CIGNAPPK_00859	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00860	0.0	-	-	-	EGP	-	-	-	Sugar (and other) transporter
CIGNAPPK_00861	6.62e-257	-	-	-	S	-	-	-	ankyrin repeats
CIGNAPPK_00862	8.62e-311	hemL	5.4.3.8	-	H	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
CIGNAPPK_00863	1.06e-44	-	-	-	J	ko:K02970	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S21
CIGNAPPK_00864	0.0	-	2.7.1.167, 2.7.7.70	-	M	ko:K03272	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	pfkB family carbohydrate kinase
CIGNAPPK_00865	6.51e-128	-	5.3.1.28	-	G	ko:K03271	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
CIGNAPPK_00866	6.23e-118	-	3.1.3.82, 3.1.3.83	-	E	ko:K03273	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Polynucleotide kinase 3 phosphatase
CIGNAPPK_00867	5e-222	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
CIGNAPPK_00869	3.51e-250	-	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	NMT1/THI5 like
CIGNAPPK_00870	1.34e-188	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_00871	1.4e-195	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_00872	2.31e-187	lpxD	2.3.1.191	-	M	ko:K02536	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIGNAPPK_00873	1.48e-120	-	-	-	M	ko:K06142	-	ko00000	Outer membrane protein (OmpH-like)
CIGNAPPK_00874	8.39e-197	panC	6.3.2.1	-	H	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIGNAPPK_00875	1.83e-150	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_00876	6.25e-144	-	-	-	-	-	-	-	-
CIGNAPPK_00877	4.86e-201	-	-	-	S	-	-	-	DisA bacterial checkpoint controller nucleotide-binding
CIGNAPPK_00879	6.94e-153	-	6.3.3.3	-	H	ko:K01935	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	AAA domain
CIGNAPPK_00880	0.0	-	-	-	G	-	-	-	beta-N-acetylhexosaminidase activity
CIGNAPPK_00881	0.0	-	-	-	S	-	-	-	Type I phosphodiesterase / nucleotide pyrophosphatase
CIGNAPPK_00882	8.16e-179	rph	2.7.7.56	-	J	ko:K00989	-	ko00000,ko01000,ko03016	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIGNAPPK_00884	1.33e-174	-	-	-	NU	-	-	-	Prepilin-type N-terminal cleavage methylation domain
CIGNAPPK_00886	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	PFAM coagulation factor 5 8 type domain protein
CIGNAPPK_00887	9.86e-168	-	-	-	M	-	-	-	Peptidase family M23
CIGNAPPK_00888	1.48e-144	nadD	2.7.7.18	-	H	ko:K00969	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIGNAPPK_00889	4.37e-200	-	5.4.99.12	-	J	ko:K06173	-	ko00000,ko01000,ko03016	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
CIGNAPPK_00892	0.0	-	-	-	S	-	-	-	Terminase
CIGNAPPK_00893	2.46e-215	-	-	-	D	ko:K19234,ko:K19236	ko01503,map01503	ko00000,ko00001,ko01002,ko01011	ErfK ybiS ycfS ynhG family protein
CIGNAPPK_00894	4.89e-153	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	Maltose acetyltransferase
CIGNAPPK_00895	3.01e-49	rpsO	-	-	J	ko:K02956	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal_S15
CIGNAPPK_00896	0.0	pnp	2.7.7.8	-	J	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
CIGNAPPK_00897	2.13e-311	tlyC	-	-	S	ko:K03699	-	ko00000,ko02042	PFAM CBS domain containing protein
CIGNAPPK_00898	4.62e-309	-	-	-	S	-	-	-	PFAM CBS domain containing protein
CIGNAPPK_00899	0.0	-	-	-	C	-	-	-	Cytochrome c554 and c-prime
CIGNAPPK_00900	1.63e-164	-	-	-	CO	-	-	-	Thioredoxin-like
CIGNAPPK_00901	1.1e-159	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
CIGNAPPK_00902	3.87e-155	-	2.5.1.3	-	H	ko:K00788	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Thiamine monophosphate synthase
CIGNAPPK_00903	8.57e-238	pyrD	1.3.5.2	-	F	ko:K00254	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydroorotate dehydrogenase
CIGNAPPK_00904	0.0	-	2.7.7.7	-	L	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase alpha chain like domain
CIGNAPPK_00905	2.12e-141	-	-	-	J	-	-	-	Acetyltransferase (GNAT) domain
CIGNAPPK_00906	0.0	-	4.1.1.15	-	E	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	ko00000,ko00001,ko00002,ko01000	Pyridoxal-dependent decarboxylase conserved domain
CIGNAPPK_00907	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_00909	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	PFAM Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_00911	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
CIGNAPPK_00912	0.0	-	-	-	KT	ko:K02584	ko02020,map02020	ko00000,ko00001,ko03000	Bacterial regulatory protein, Fis family
CIGNAPPK_00913	9.68e-221	-	2.5.1.21	-	I	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko01006	Squalene/phytoene synthase
CIGNAPPK_00914	0.0	-	-	-	S	-	-	-	Fungal chitosanase of glycosyl hydrolase group 75
CIGNAPPK_00915	3.14e-192	-	-	-	S	ko:K07124	-	ko00000	Enoyl-(Acyl carrier protein) reductase
CIGNAPPK_00916	8.38e-98	-	-	-	-	-	-	-	-
CIGNAPPK_00917	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
CIGNAPPK_00920	9.85e-147	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
CIGNAPPK_00925	2.63e-302	-	-	-	MU	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	efflux transmembrane transporter activity
CIGNAPPK_00928	4.36e-200	menB	4.1.3.36	-	H	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Enoyl-CoA hydratase/isomerase
CIGNAPPK_00929	6.38e-258	-	-	-	S	-	-	-	AAA domain, putative AbiEii toxin, Type IV TA system
CIGNAPPK_00931	0.0	ftsH	-	-	O	ko:K03798	-	ko00000,ko00002,ko01000,ko01002,ko03110	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIGNAPPK_00932	4.69e-79	rsfS	-	-	S	ko:K09710	-	ko00000,ko03009	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
CIGNAPPK_00933	0.0	mutS	-	-	L	ko:K03555	ko03430,map03430	ko00000,ko00001,ko03400	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIGNAPPK_00934	9.22e-141	-	2.7.7.7	-	L	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Exonuclease
CIGNAPPK_00935	7.74e-174	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
CIGNAPPK_00936	0.0	-	-	-	CO	-	-	-	Disulphide bond corrector protein DsbC
CIGNAPPK_00937	1.86e-94	-	-	-	O	-	-	-	OsmC-like protein
CIGNAPPK_00939	3.42e-111	-	3.5.4.12	-	F	ko:K01493	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000,ko02044	Cytidine and deoxycytidylate deaminase zinc-binding region
CIGNAPPK_00940	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
CIGNAPPK_00942	2.94e-204	-	1.3.1.12	-	E	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Prephenate dehydrogenase
CIGNAPPK_00943	0.0	-	-	-	P	ko:K02014	-	ko00000,ko02000	TonB dependent receptor
CIGNAPPK_00944	4.97e-168	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_00945	0.0	-	-	-	V	ko:K02004	-	ko00000,ko00002,ko02000	MacB-like periplasmic core domain
CIGNAPPK_00947	1.78e-154	cat	2.3.1.28	-	V	ko:K19271	-	br01600,ko00000,ko01000,ko01504	Chloramphenicol acetyltransferase
CIGNAPPK_00949	1.24e-230	-	-	-	EP	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Oligopeptide/dipeptide transporter, C-terminal region
CIGNAPPK_00950	0.0	der	-	-	S	ko:K03977	-	ko00000,ko03009	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal
CIGNAPPK_00951	9.67e-251	-	-	-	S	ko:K07091	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Predicted permease YjgP/YjgQ family
CIGNAPPK_00952	1.1e-125	-	-	-	L	ko:K03584	ko03440,map03440	ko00000,ko00001,ko03400	Recombination protein O N terminal
CIGNAPPK_00953	3.99e-183	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_00954	0.0	dxs	2.2.1.7	-	HI	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIGNAPPK_00955	3.08e-52	xseB	3.1.11.6	-	L	ko:K03602	ko03430,map03430	ko00000,ko00001,ko01000,ko03400	exodeoxyribonuclease VII activity
CIGNAPPK_00956	0.0	-	-	-	O	-	-	-	C-terminal four TMM region of protein-O-mannosyltransferase
CIGNAPPK_00957	0.0	-	-	-	T	-	-	-	Bacterial regulatory protein, Fis family
CIGNAPPK_00958	1.82e-274	-	-	-	T	-	-	-	PAS domain
CIGNAPPK_00959	8.28e-98	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase superfamily
CIGNAPPK_00960	0.0	gpmI	5.4.2.12	-	G	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	BPG-independent PGAM N-terminus (iPGM_N)
CIGNAPPK_00961	4.16e-85	-	-	-	J	ko:K02950	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S12/S23
CIGNAPPK_00962	2.91e-104	-	-	-	J	ko:K02992	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S7p/S5e
CIGNAPPK_00963	0.0	-	-	-	J	ko:K02355	-	ko00000,ko03012,ko03029	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIGNAPPK_00964	3.67e-65	-	-	-	J	ko:K02946	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S10p/S20e
CIGNAPPK_00965	3.86e-149	rplC	-	-	J	ko:K02906	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIGNAPPK_00966	1.82e-129	rplD	-	-	J	ko:K02926	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L4/L1 family
CIGNAPPK_00967	8.72e-58	rplW	-	-	J	ko:K02892	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
CIGNAPPK_00968	1.85e-203	rplB	-	-	J	ko:K02886	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIGNAPPK_00969	1.05e-58	rpsS	-	-	J	ko:K02965	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIGNAPPK_00970	4.05e-152	-	-	-	-	-	-	-	-
CIGNAPPK_00971	4.97e-70	-	-	-	J	ko:K02890	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
CIGNAPPK_00972	5.2e-156	rpsC	-	-	J	ko:K02982	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIGNAPPK_00973	6.89e-97	-	-	-	J	ko:K02878	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIGNAPPK_00974	2.36e-34	-	-	-	J	ko:K02904	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L29 protein
CIGNAPPK_00975	2.19e-56	rpsQ	-	-	J	ko:K02961	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIGNAPPK_00976	6.79e-79	rplN	-	-	J	ko:K02874	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIGNAPPK_00977	6.2e-203	-	-	-	-	-	-	-	-
CIGNAPPK_00978	0.0	valS	6.1.1.9	-	J	ko:K01873	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
CIGNAPPK_00979	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Domain of unknown function (DUF4982)
CIGNAPPK_00980	3.33e-254	-	5.2.1.8	-	O	ko:K03771	-	ko00000,ko01000,ko03110	SurA N-terminal domain
CIGNAPPK_00981	1.82e-171	-	2.5.1.39	-	H	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01006	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIGNAPPK_00982	1.43e-142	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
CIGNAPPK_00988	1.9e-62	-	-	-	L	-	-	-	bacterial (prokaryotic) histone like domain
CIGNAPPK_00989	4.03e-206	-	3.1.26.4	-	L	ko:K03471	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
CIGNAPPK_00990	2.43e-126	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
CIGNAPPK_00991	1.45e-172	-	-	-	F	-	-	-	NUDIX domain
CIGNAPPK_00992	1.42e-149	trmB	2.1.1.33	-	J	ko:K03439	-	ko00000,ko01000,ko03016	Putative methyltransferase
CIGNAPPK_00993	1.39e-282	tgt	2.4.2.29	-	J	ko:K00773	-	ko00000,ko01000,ko03016	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
CIGNAPPK_00994	5.64e-66	-	-	-	U	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase subunit
CIGNAPPK_00995	6.5e-186	-	-	-	DTZ	-	-	-	EF-hand, calcium binding motif
CIGNAPPK_00996	4.58e-215	-	-	-	L	ko:K03733	-	ko00000,ko03036	Phage integrase, N-terminal SAM-like domain
CIGNAPPK_00997	7.74e-08	-	-	-	E	-	-	-	LysE type translocator
CIGNAPPK_00999	9.56e-51	-	-	-	J	ko:K02959	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Ribosomal protein S16
CIGNAPPK_01000	1.55e-128	aroK	2.7.1.71	-	E	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIGNAPPK_01001	6.97e-241	-	2.7.7.87	-	J	ko:K07566	-	ko00000,ko01000,ko03009,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
CIGNAPPK_01002	6.98e-80	-	-	-	FG	ko:K02503	-	ko00000,ko04147	HIT domain
CIGNAPPK_01003	2.03e-116	-	-	-	S	ko:K07040	-	ko00000	Uncharacterized ACR, COG1399
CIGNAPPK_01004	2.73e-38	rpmF	-	-	J	ko:K02911	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	Belongs to the bacterial ribosomal protein bL32 family
CIGNAPPK_01005	1.22e-246	plsX	2.3.1.15	-	I	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
CIGNAPPK_01006	0.0	-	-	-	S	ko:K07037	-	ko00000	7TM receptor with intracellular HD hydrolase
CIGNAPPK_01007	1.17e-116	ybeY	-	-	S	ko:K07042	-	ko00000,ko03009	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIGNAPPK_01009	2.58e-28	-	-	-	L	-	-	-	Belongs to the 'phage' integrase family
CIGNAPPK_01016	9.41e-72	-	-	-	KT	-	-	-	Peptidase S24-like
CIGNAPPK_01020	5.55e-49	-	-	-	S	-	-	-	AAA domain
CIGNAPPK_01027	3.45e-11	-	2.1.1.37, 3.1.21.4	-	L	ko:K00558,ko:K01155	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	DNA (cytosine-5-)-methyltransferase activity
CIGNAPPK_01028	3.31e-47	-	-	-	L	-	-	-	DNA restriction-modification system
CIGNAPPK_01029	5.14e-32	-	-	-	K	-	-	-	ROK family
CIGNAPPK_01030	1.14e-137	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
CIGNAPPK_01034	1.49e-08	-	-	-	-	-	-	-	-
CIGNAPPK_01038	0.0	-	-	-	S	-	-	-	Carbohydrate esterase, sialic acid-specific acetylesterase
CIGNAPPK_01039	1.04e-109	nrdR	-	-	K	ko:K07738	-	ko00000,ko03000	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIGNAPPK_01040	7.2e-125	-	-	-	-	-	-	-	-
CIGNAPPK_01041	0.0	-	-	-	U	ko:K03321	-	ko00000,ko02000	Sulfate permease family
CIGNAPPK_01042	0.0	argH	4.3.2.1	-	E	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Argininosuccinate lyase C-terminal
CIGNAPPK_01043	4.32e-164	-	-	-	S	-	-	-	SWIM zinc finger
CIGNAPPK_01044	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01045	2.46e-307	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
CIGNAPPK_01046	4.2e-204	nfo	3.1.21.2	-	L	ko:K01151	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CIGNAPPK_01047	7.24e-24	-	-	-	K	-	-	-	SMART regulatory protein ArsR
CIGNAPPK_01048	2.05e-15	-	-	-	CO	-	-	-	Thioredoxin domain
CIGNAPPK_01049	6.86e-37	-	-	-	CO	-	-	-	PFAM cytochrome c biogenesis protein, transmembrane region
CIGNAPPK_01050	1.74e-159	-	-	-	P	ko:K07089	-	ko00000	Predicted permease
CIGNAPPK_01051	6.63e-258	-	-	-	S	ko:K03698	-	ko00000,ko01000,ko03019	Metal dependent phosphohydrolases with conserved 'HD' motif.
CIGNAPPK_01052	0.0	-	-	-	S	ko:K02238	-	ko00000,ko00002,ko02044	Competence protein
CIGNAPPK_01053	0.0	miaB	2.8.4.3	-	J	ko:K06168	-	ko00000,ko01000,ko03016	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIGNAPPK_01054	1.91e-302	-	2.1.1.190	-	J	ko:K03215	-	ko00000,ko01000,ko03009	tRNA (Uracil-5-)-methyltransferase
CIGNAPPK_01057	0.0	hsdM	2.1.1.72	-	V	ko:K03427	-	ko00000,ko01000,ko02048	COG0286 Type I restriction-modification system methyltransferase subunit
CIGNAPPK_01058	7.05e-148	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	Type I restriction modification DNA specificity domain
CIGNAPPK_01059	2.53e-205	-	-	-	V	-	-	-	AAA domain
CIGNAPPK_01060	0.0	hsdR	3.1.21.3	-	V	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CIGNAPPK_01061	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01062	7.36e-55	himA	-	-	L	ko:K03530,ko:K04764,ko:K05788	-	ko00000,ko03032,ko03036,ko03400	regulation of translation
CIGNAPPK_01063	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Glycosyl hydrolase family 36 N-terminal domain
CIGNAPPK_01064	0.0	-	-	-	P	ko:K07085	-	ko00000	Predicted Permease Membrane Region
CIGNAPPK_01065	4.64e-111	-	-	-	T	ko:K03413	ko02020,ko02030,map02020,map02030	ko00000,ko00001,ko00002,ko02022,ko02035	cheY-homologous receiver domain
CIGNAPPK_01066	0.0	-	-	-	T	-	-	-	Histidine kinase
CIGNAPPK_01067	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
CIGNAPPK_01068	1.07e-188	-	1.97.1.4	-	O	ko:K04069	-	ko00000,ko01000	Radical SAM superfamily
CIGNAPPK_01069	3.8e-43	nrdD	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	CTP reductase activity
CIGNAPPK_01070	0.0	-	1.1.98.6	-	F	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Anaerobic ribonucleoside-triphosphate reductase
CIGNAPPK_01071	0.0	-	-	-	M	-	-	-	Glycosyl Hydrolase Family 88
CIGNAPPK_01072	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF1705)
CIGNAPPK_01074	1.96e-121	ngr	-	-	C	-	-	-	Rubrerythrin
CIGNAPPK_01076	8.88e-268	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
CIGNAPPK_01077	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_01078	4.93e-286	-	-	-	EGP	-	-	-	Major facilitator Superfamily
CIGNAPPK_01079	1.18e-276	-	3.1.3.1	-	P	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	Alkaline phosphatase homologues
CIGNAPPK_01080	3.06e-85	-	-	-	M	ko:K03282	-	ko00000,ko02000	Large-conductance mechanosensitive channel, MscL
CIGNAPPK_01081	1.95e-312	-	2.6.1.11, 2.6.1.17	-	E	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
CIGNAPPK_01082	1.2e-105	-	-	-	S	-	-	-	ACT domain protein
CIGNAPPK_01083	9.29e-132	-	-	-	J	ko:K02356	-	ko00000,ko03012	Elongation factor P (EF-P) OB domain
CIGNAPPK_01084	4.72e-244	-	-	-	G	-	-	-	Glycosyl hydrolases family 16
CIGNAPPK_01085	0.0	-	3.6.3.54	-	P	ko:K17686	ko01524,ko04016,map01524,map04016	ko00000,ko00001,ko01000	E1-E2 ATPase
CIGNAPPK_01086	0.0	-	-	-	L	ko:K03631	-	ko00000,ko03400	RecF/RecN/SMC N terminal domain
CIGNAPPK_01087	3.71e-190	-	3.1.4.55	-	S	ko:K06167	ko00440,map00440	ko00000,ko00001,ko01000	Metallo-beta-lactamase superfamily
CIGNAPPK_01088	1.76e-192	-	-	-	M	-	-	-	Glycosyl transferase WecB/TagA/CpsF family
CIGNAPPK_01089	2.14e-171	yyaQ	-	-	V	-	-	-	Protein conserved in bacteria
CIGNAPPK_01090	1.34e-90	-	-	-	-	-	-	-	-
CIGNAPPK_01093	4.72e-206	-	-	-	S	ko:K09949	-	ko00000	Protein of unknown function (DUF1009)
CIGNAPPK_01094	1.63e-298	-	2.3.1.12	-	C	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
CIGNAPPK_01095	9.47e-236	-	1.2.4.1	-	C	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Transketolase, pyrimidine binding domain
CIGNAPPK_01096	1.13e-221	-	1.2.4.1	-	C	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	br01601,ko00000,ko00001,ko00002,ko01000	Dehydrogenase E1 component
CIGNAPPK_01097	6.65e-193	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CIGNAPPK_01098	1e-242	-	-	-	M	ko:K18094	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	Biotin-lipoyl like
CIGNAPPK_01099	0.0	-	-	-	V	ko:K18095	ko01501,ko02020,map01501,map02020	ko00000,ko00001,ko00002,ko01504,ko02000	AcrB/AcrD/AcrF family
CIGNAPPK_01100	0.0	-	-	-	S	-	-	-	pathogenesis
CIGNAPPK_01101	2.1e-99	-	-	-	S	-	-	-	peptidase
CIGNAPPK_01102	3e-171	-	-	-	S	ko:K06973	-	ko00000	Putative neutral zinc metallopeptidase
CIGNAPPK_01103	6.42e-101	-	-	-	S	-	-	-	peptidase
CIGNAPPK_01104	0.0	-	2.1.1.107, 4.2.1.75	-	H	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Uroporphyrinogen-III synthase HemD
CIGNAPPK_01105	9.54e-102	-	-	-	-	-	-	-	-
CIGNAPPK_01106	0.0	-	5.99.1.2	-	L	ko:K03169	-	ko00000,ko01000,ko03032	Bacterial DNA topoisomeraes I ATP-binding domain
CIGNAPPK_01110	8.8e-169	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
CIGNAPPK_01111	0.0	-	4.2.1.3	-	C	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Aconitase C-terminal domain
CIGNAPPK_01112	2.57e-133	-	-	-	D	-	-	-	ErfK ybiS ycfS ynhG family protein
CIGNAPPK_01113	3.56e-284	msrA	1.8.4.11, 1.8.4.12	-	O	ko:K12267	-	ko00000,ko01000	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIGNAPPK_01116	0.0	-	-	-	E	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	transmembrane transport
CIGNAPPK_01117	1.17e-271	-	-	-	S	-	-	-	tRNA-splicing ligase RtcB
CIGNAPPK_01118	2.75e-214	-	-	-	K	-	-	-	LysR substrate binding domain
CIGNAPPK_01119	3.03e-296	-	-	-	EGP	-	-	-	Major facilitator Superfamily
CIGNAPPK_01121	4.11e-129	-	-	-	S	-	-	-	Cobalamin adenosyltransferase
CIGNAPPK_01122	3.78e-74	-	-	-	L	-	-	-	Cupin 2, conserved barrel domain protein
CIGNAPPK_01123	0.0	rnr	-	-	K	ko:K12573	ko03018,map03018	ko00000,ko00001,ko01000,ko03016,ko03019	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
CIGNAPPK_01125	0.0	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Collagenase
CIGNAPPK_01126	1.53e-286	-	6.3.2.12, 6.3.2.17	-	H	ko:K11754	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Mur ligase middle domain
CIGNAPPK_01128	0.0	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
CIGNAPPK_01129	0.0	-	2.7.11.1	-	L	ko:K08282	-	ko00000,ko01000	SNF2 Helicase protein
CIGNAPPK_01130	0.0	-	3.1.3.5	-	F	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	ko00000,ko00001,ko01000	Calcineurin-like phosphoesterase
CIGNAPPK_01131	1.77e-124	-	-	-	M	ko:K03642	-	ko00000	Lytic transglycolase
CIGNAPPK_01132	4.2e-208	nadK	2.7.1.23	-	G	ko:K00858	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko01000	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIGNAPPK_01133	1.53e-47	rplX	-	-	J	ko:K02895	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S L24/mitochondrial 39S L24
CIGNAPPK_01134	5.36e-138	rplE	-	-	J	ko:K02931	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIGNAPPK_01135	4.08e-88	rpsH	-	-	J	ko:K02994	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIGNAPPK_01136	2.25e-105	rplF	-	-	J	ko:K02933	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIGNAPPK_01137	2.38e-74	rplR	-	-	J	ko:K02881	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIGNAPPK_01138	3.38e-102	rpsE	-	-	J	ko:K02988	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIGNAPPK_01139	6.42e-101	rplO	-	-	J	ko:K02876	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
CIGNAPPK_01141	0.0	secY	-	-	U	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
CIGNAPPK_01142	6.41e-155	adk	2.7.4.3	-	F	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko04147	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
CIGNAPPK_01143	1.29e-192	map	3.4.11.18	-	J	ko:K01265	-	ko00000,ko01000,ko01002	Metallopeptidase family M24
CIGNAPPK_01144	1.64e-263	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_01145	0.0	-	3.6.1.11, 3.6.1.40	-	FP	ko:K01524	ko00230,map00230	ko00000,ko00001,ko01000	Ppx/GppA phosphatase family
CIGNAPPK_01146	0.0	-	2.7.4.1	-	P	ko:K00937	ko00190,ko03018,map00190,map03018	ko00000,ko00001,ko01000,ko03019	Polyphosphate kinase middle domain
CIGNAPPK_01147	8.71e-283	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
CIGNAPPK_01149	1.89e-275	-	-	GT2	S	ko:K19427	-	ko00000,ko01000	PFAM glycosyl transferase family 2
CIGNAPPK_01150	3.06e-226	-	-	-	S	-	-	-	Glycosyl transferase family 11
CIGNAPPK_01151	2.94e-264	-	-	-	S	-	-	-	Glycosyltransferase like family 2
CIGNAPPK_01152	1.82e-296	-	-	-	-	-	-	-	-
CIGNAPPK_01153	3.2e-267	-	-	-	S	-	-	-	PFAM glycosyl transferase family 2
CIGNAPPK_01154	3.93e-128	-	3.5.1.124	-	S	ko:K03152	-	ko00000,ko01000,ko01002	DJ-1/PfpI family
CIGNAPPK_01155	1.38e-230	-	-	-	C	-	-	-	e3 binding domain
CIGNAPPK_01156	4.34e-284	-	3.5.1.25	-	G	ko:K01443	ko00520,ko01130,map00520,map01130	ko00000,ko00001,ko01000	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIGNAPPK_01157	4.05e-135	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIGNAPPK_01158	0.0	-	-	-	EGIP	-	-	-	Phosphate acyltransferases
CIGNAPPK_01159	0.0	-	-	-	T	-	-	-	5TM C-terminal transporter carbon starvation CstA
CIGNAPPK_01160	4.68e-159	-	-	-	-	-	-	-	-
CIGNAPPK_01161	0.0	-	-	-	P	-	-	-	PA14 domain
CIGNAPPK_01162	2e-82	rbfA	-	-	J	ko:K02834	-	ko00000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CIGNAPPK_01163	0.0	infB	-	-	J	ko:K02519	-	ko00000,ko03012,ko03029	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIGNAPPK_01164	5.58e-289	nusA	-	-	K	ko:K02600	-	ko00000,ko03009,ko03021	NusA-like KH domain
CIGNAPPK_01165	3.73e-195	-	3.1.11.2	-	L	ko:K01142	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Endonuclease/Exonuclease/phosphatase family
CIGNAPPK_01166	2.35e-142	-	3.6.1.66	-	F	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIGNAPPK_01167	6.08e-135	-	-	-	J	-	-	-	Putative rRNA methylase
CIGNAPPK_01168	1.63e-203	-	-	-	S	-	-	-	Domain of unknown function (DUF362)
CIGNAPPK_01169	0.0	-	-	-	C	-	-	-	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein
CIGNAPPK_01170	0.0	-	-	-	V	-	-	-	ABC-2 type transporter
CIGNAPPK_01172	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01173	3.54e-185	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_01174	7.33e-143	-	-	-	S	-	-	-	RNA recognition motif
CIGNAPPK_01175	0.0	-	-	-	M	-	-	-	Bacterial sugar transferase
CIGNAPPK_01176	3.1e-284	-	2.7.1.6	-	G	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000,ko04147	Galactokinase galactose-binding signature
CIGNAPPK_01177	0.0	-	-	-	S	ko:K03307	-	ko00000	Sodium:solute symporter family
CIGNAPPK_01179	0.0	-	3.6.4.12	-	L	ko:K03657	ko03420,ko03430,map03420,map03430	ko00000,ko00001,ko01000,ko03400	UvrD-like helicase C-terminal domain
CIGNAPPK_01180	3.02e-227	fmt	2.1.2.9	-	J	ko:K00604	ko00670,ko00970,map00670,map00970	ko00000,ko00001,ko01000	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIGNAPPK_01181	1.13e-271	-	-	-	M	-	-	-	Monogalactosyldiacylglycerol (MGDG) synthase
CIGNAPPK_01182	1.39e-171	coaX	2.7.1.33	-	K	ko:K03525	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Type III pantothenate kinase
CIGNAPPK_01183	8.56e-45	acpP	-	-	IQ	ko:K02078	-	ko00000,ko00001	Phosphopantetheine attachment site
CIGNAPPK_01184	1e-131	-	-	-	-	-	-	-	-
CIGNAPPK_01185	4.09e-175	-	-	-	S	-	-	-	Lysin motif
CIGNAPPK_01186	2.52e-97	dtd	-	-	J	ko:K07560	-	ko00000,ko01000,ko03016	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
CIGNAPPK_01187	2.42e-73	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_01188	6.06e-221	-	-	-	M	-	-	-	self proteolysis
CIGNAPPK_01189	4.81e-153	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_01190	0.0	-	-	-	E	-	-	-	Sodium:solute symporter family
CIGNAPPK_01191	0.0	pyrG	6.3.4.2	-	F	ko:K01937	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
CIGNAPPK_01192	3.42e-180	kdsB	2.7.7.38	-	M	ko:K00979	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CIGNAPPK_01193	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01195	2.88e-249	ppiD	5.2.1.8	-	O	ko:K03769,ko:K03770,ko:K03771,ko:K07533	-	ko00000,ko01000,ko03110	peptidyl-prolyl cis-trans isomerase activity
CIGNAPPK_01196	3.71e-260	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
CIGNAPPK_01197	5.1e-265	-	-	-	NU	ko:K02669	-	ko00000,ko02035,ko02044	Type II/IV secretion system protein
CIGNAPPK_01200	2.69e-38	-	-	-	T	-	-	-	ribosome binding
CIGNAPPK_01201	6.61e-232	-	-	-	Q	ko:K02067	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MlaD protein
CIGNAPPK_01202	4.3e-190	-	-	-	Q	ko:K02065	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_01203	2.58e-168	-	-	-	Q	ko:K02066	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Permease MlaE
CIGNAPPK_01204	0.0	-	-	-	H	-	-	-	NAD synthase
CIGNAPPK_01205	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
CIGNAPPK_01206	0.0	-	-	-	V	ko:K11085	ko02010,map02010	ko00000,ko00001,ko01000,ko02000	ABC transporter transmembrane region
CIGNAPPK_01207	0.0	-	5.4.2.2	-	G	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
CIGNAPPK_01208	1.72e-147	-	-	-	M	-	-	-	NLP P60 protein
CIGNAPPK_01209	3.38e-294	ftsA	-	-	D	ko:K03590	ko04112,map04112	ko00000,ko00001,ko03036,ko04812	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
CIGNAPPK_01210	7.7e-312	-	-	-	D	ko:K03531	ko04112,map04112	ko00000,ko00001,ko02048,ko03036,ko04812	Tubulin/FtsZ family, GTPase domain
CIGNAPPK_01213	7.11e-235	-	-	-	S	ko:K01128	-	ko00000,ko01000	acid phosphatase activity
CIGNAPPK_01214	6.5e-311	-	1.5.1.7	-	E	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Saccharopine dehydrogenase C-terminal domain
CIGNAPPK_01215	1.53e-219	-	-	-	O	-	-	-	Thioredoxin-like domain
CIGNAPPK_01216	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
CIGNAPPK_01217	0.0	-	-	-	E	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Bacterial extracellular solute-binding proteins, family 5 Middle
CIGNAPPK_01218	1.31e-216	-	-	-	EP	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_01219	1.6e-213	-	-	-	EP	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	ko00000,ko00001,ko00002,ko02000	N-terminal TM domain of oligopeptide transport permease C
CIGNAPPK_01220	6.05e-86	-	-	-	S	ko:K09922	-	ko00000	Putative member of DMT superfamily (DUF486)
CIGNAPPK_01221	7.04e-279	-	6.1.1.1	-	J	ko:K01866	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	tRNA synthetases class I (W and Y)
CIGNAPPK_01222	9.48e-237	-	-	-	S	ko:K14347	-	ko00000,ko02000,ko04147	SBF-like CPA transporter family (DUF4137)
CIGNAPPK_01225	0.0	-	-	-	S	-	-	-	Large extracellular alpha-helical protein
CIGNAPPK_01226	0.0	-	-	-	M	-	-	-	Aerotolerance regulator N-terminal
CIGNAPPK_01227	1.77e-235	-	-	-	S	-	-	-	Peptidase family M28
CIGNAPPK_01228	1.24e-200	-	-	-	K	ko:K03497	-	ko00000,ko03000,ko03036,ko04812	ParB-like nuclease domain
CIGNAPPK_01231	8.73e-131	-	-	-	S	-	-	-	Glycosyl hydrolase 108
CIGNAPPK_01233	0.0	-	-	-	L	ko:K02621	-	ko00000,ko01000,ko02048,ko03032,ko03036	DNA Topoisomerase IV
CIGNAPPK_01234	1.83e-74	-	-	-	-	-	-	-	-
CIGNAPPK_01236	4.02e-188	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
CIGNAPPK_01237	0.0	-	-	-	G	-	-	-	cellulose 1,4-beta-cellobiosidase activity
CIGNAPPK_01238	5.84e-81	feoB	-	-	P	ko:K04759	-	ko00000,ko02000	transporter of a GTP-driven Fe(2 ) uptake system
CIGNAPPK_01240	0.0	-	-	-	P	-	-	-	Domain of unknown function
CIGNAPPK_01241	1.12e-302	-	-	-	S	-	-	-	AI-2E family transporter
CIGNAPPK_01242	0.0	rseP	3.4.21.116	-	M	ko:K06399,ko:K11749	ko02024,ko04112,map02024,map04112	ko00000,ko00001,ko01000,ko01002	metalloendopeptidase activity
CIGNAPPK_01243	2.11e-89	-	-	-	-	-	-	-	-
CIGNAPPK_01244	4.36e-266	-	3.5.3.12	-	E	ko:K10536	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Porphyromonas-type peptidyl-arginine deiminase
CIGNAPPK_01245	0.0	-	-	-	H	ko:K07137	-	ko00000	5-formyltetrahydrofolate cyclo-ligase activity
CIGNAPPK_01247	3.73e-90	-	5.4.99.18	-	F	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR carboxylase
CIGNAPPK_01248	1.15e-122	-	2.4.2.9	-	F	ko:K02825	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000,ko03000	Phosphoribosyl transferase domain
CIGNAPPK_01249	3.64e-221	pyrB	2.1.3.2	-	F	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
CIGNAPPK_01250	5.56e-306	-	3.5.2.3	-	F	ko:K01465	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Dihydro-orotase-like
CIGNAPPK_01251	1.39e-162	-	-	-	S	-	-	-	Uncharacterised protein family UPF0066
CIGNAPPK_01252	1.16e-86	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CIGNAPPK_01253	1.41e-281	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIGNAPPK_01254	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIGNAPPK_01255	6.41e-284	-	-	-	V	-	-	-	Beta-lactamase
CIGNAPPK_01256	9.1e-317	-	-	-	MU	-	-	-	Outer membrane efflux protein
CIGNAPPK_01257	3.42e-313	-	-	-	V	-	-	-	MacB-like periplasmic core domain
CIGNAPPK_01258	2.12e-162	-	-	-	V	ko:K02003	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_01259	3.51e-284	-	-	-	M	ko:K02005	-	ko00000	HlyD family secretion protein
CIGNAPPK_01261	5.75e-98	nudI	3.6.1.55	-	F	ko:K03574,ko:K12944	-	ko00000,ko01000,ko03400	GDP-mannose mannosyl hydrolase activity
CIGNAPPK_01262	4.56e-125	-	-	-	S	ko:K07095	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
CIGNAPPK_01263	2.86e-245	sun	2.1.1.176, 2.1.1.178	-	J	ko:K03500,ko:K11392	-	ko00000,ko01000,ko03009	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIGNAPPK_01264	5.9e-232	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
CIGNAPPK_01265	1.46e-118	-	-	-	T	-	-	-	Prokaryotic dksA/traR C4-type zinc finger
CIGNAPPK_01266	5.67e-33	rpmG	-	-	J	ko:K02913	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L33
CIGNAPPK_01267	4.52e-49	-	-	-	J	ko:K02963	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S18
CIGNAPPK_01268	3.84e-189	folE2	3.5.4.16	-	S	ko:K09007	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Type I GTP cyclohydrolase folE2
CIGNAPPK_01269	1.02e-178	-	-	-	S	-	-	-	Cytochrome C assembly protein
CIGNAPPK_01270	7.78e-238	hemA	1.2.1.70	-	H	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Glutamyl-tRNAGlu reductase, N-terminal domain
CIGNAPPK_01271	2.31e-232	-	2.5.1.61	-	H	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000	Porphobilinogen deaminase, dipyromethane cofactor binding domain
CIGNAPPK_01273	8.67e-85	-	-	-	S	-	-	-	Protein of unknown function, DUF488
CIGNAPPK_01274	0.0	hsdR	3.1.21.3	-	L	ko:K01153	-	ko00000,ko01000,ko02048	Subunit R is required for both nuclease and ATPase activities, but not for modification
CIGNAPPK_01275	2.99e-28	-	3.1.21.3	-	V	ko:K01154	-	ko00000,ko01000,ko02048	type i restriction
CIGNAPPK_01276	0.0	-	2.1.1.72	-	L	ko:K03427	-	ko00000,ko01000,ko02048	type I restriction-modification system
CIGNAPPK_01277	0.0	-	-	-	M	ko:K02847,ko:K13009,ko:K16705	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	-O-antigen
CIGNAPPK_01278	0.0	mutL	-	-	L	ko:K03572	ko03430,map03430	ko00000,ko00001,ko03400	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIGNAPPK_01279	1.04e-54	thiS	-	-	H	ko:K03154	ko04122,map04122	ko00000,ko00001	thiamine diphosphate biosynthetic process
CIGNAPPK_01287	6.38e-118	-	2.1.1.37	-	L	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	C-5 cytosine-specific DNA methylase
CIGNAPPK_01298	2.87e-71	-	-	-	S	-	-	-	Phage terminase large subunit (GpA)
CIGNAPPK_01303	3.99e-22	-	-	-	OU	-	-	-	Serine dehydrogenase proteinase
CIGNAPPK_01313	3.44e-17	-	-	-	D	-	-	-	nuclear chromosome segregation
CIGNAPPK_01321	3.84e-33	-	-	-	M	-	-	-	Peptidoglycan-binding domain 1 protein
CIGNAPPK_01322	1.07e-10	-	-	-	K	ko:K07726	-	ko00000,ko03000	Helix-turn-helix XRE-family like proteins
CIGNAPPK_01332	0.0	-	-	-	S	ko:K07126	-	ko00000	beta-lactamase activity
CIGNAPPK_01333	1.06e-182	-	-	-	D	ko:K03496	-	ko00000,ko03036,ko04812	AAA domain
CIGNAPPK_01334	0.0	-	-	-	KLT	-	-	-	Sulfatase-modifying factor enzyme 1
CIGNAPPK_01335	3.77e-289	kbl	2.3.1.29	-	E	ko:K00639	ko00260,map00260	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_01336	9.23e-124	-	3.6.1.55	-	F	ko:K03574	-	ko00000,ko01000,ko03400	NUDIX domain
CIGNAPPK_01337	1.17e-231	-	2.7.1.4	-	G	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	ko00000,ko00001,ko01000	pfkB family carbohydrate kinase
CIGNAPPK_01339	9.9e-121	-	-	-	-	-	-	-	-
CIGNAPPK_01340	5.86e-184	-	-	-	H	ko:K22132	-	ko00000,ko03016	ThiF family
CIGNAPPK_01341	1.45e-190	-	-	-	S	ko:K09769	-	ko00000	YmdB-like protein
CIGNAPPK_01342	1.56e-103	-	-	-	T	-	-	-	Universal stress protein family
CIGNAPPK_01343	1.02e-233	-	6.1.1.2	-	J	ko:K01867	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (W and Y)
CIGNAPPK_01344	5.1e-204	-	-	-	GM	-	-	-	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIGNAPPK_01345	2.14e-165	-	2.7.7.60	-	I	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
CIGNAPPK_01346	8.39e-89	-	-	-	S	ko:K09117	-	ko00000	Yqey-like protein
CIGNAPPK_01347	8.61e-222	-	-	-	CO	-	-	-	amine dehydrogenase activity
CIGNAPPK_01348	0.0	-	2.3.3.13	-	E	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	HMGL-like
CIGNAPPK_01349	1e-214	-	-	-	Q	-	-	-	Fumarylacetoacetate (FAA) hydrolase family
CIGNAPPK_01350	6e-76	-	-	-	P	ko:K03972	-	ko00000	Rhodanese Homology Domain
CIGNAPPK_01351	0.0	-	3.2.1.50	-	G	ko:K01205	ko00531,ko01100,ko04142,map00531,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha-L-fucosidase
CIGNAPPK_01352	0.0	-	-	-	O	ko:K03696	ko01100,map01100	ko00000,ko03110	C-terminal, D2-small domain, of ClpB protein
CIGNAPPK_01353	8.21e-246	-	2.7.14.1	-	E	ko:K19405	-	ko00000,ko01000	ATP:guanido phosphotransferase, C-terminal catalytic domain
CIGNAPPK_01354	5.46e-126	-	-	-	S	ko:K19411	-	ko00000	UvrB/uvrC motif
CIGNAPPK_01355	1.34e-180	-	-	-	P	ko:K09819	-	ko00000,ko00002,ko02000	FecCD transport family
CIGNAPPK_01356	1.52e-192	-	-	-	P	ko:K09820	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
CIGNAPPK_01357	2.03e-100	-	-	-	-	-	-	-	-
CIGNAPPK_01358	7.15e-230	-	-	-	P	ko:K02077	-	ko00000,ko00002,ko02000	Zinc-uptake complex component A periplasmic
CIGNAPPK_01359	0.0	hyl	2.3.1.48, 3.2.1.169, 3.2.1.35	GH84	G	ko:K01197,ko:K15719	ko00531,ko01100,ko04931,map00531,map01100,map04931	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	beta-N-acetylhexosaminidase activity
CIGNAPPK_01360	0.0	-	-	-	L	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
CIGNAPPK_01362	5.04e-58	-	-	-	S	-	-	-	peptidoglycan biosynthetic process
CIGNAPPK_01363	1.3e-206	-	1.4.1.16	-	S	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CIGNAPPK_01365	0.000103	-	-	-	S	-	-	-	Entericidin EcnA/B family
CIGNAPPK_01366	3.46e-234	-	-	-	S	ko:K07192	ko04910,map04910	ko00000,ko00001,ko03036,ko04131,ko04147	prohibitin homologues
CIGNAPPK_01367	2.13e-118	-	-	-	-	-	-	-	-
CIGNAPPK_01368	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
CIGNAPPK_01369	2.22e-298	lpxK	2.7.1.130	-	M	ko:K00912	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
CIGNAPPK_01370	1.94e-140	-	-	-	S	ko:K07164	-	ko00000	C4-type zinc ribbon domain
CIGNAPPK_01371	3.18e-264	-	3.1.13.5	-	J	ko:K03684	-	ko00000,ko01000,ko03016	3'-5' exonuclease
CIGNAPPK_01372	3.68e-75	-	-	-	-	-	-	-	-
CIGNAPPK_01373	4.15e-191	-	3.6.1.66	-	S	ko:K02428	ko00230,map00230	ko00000,ko00001,ko01000	MazG nucleotide pyrophosphohydrolase domain
CIGNAPPK_01374	2.06e-70	-	-	-	-	-	-	-	-
CIGNAPPK_01375	1.69e-180	-	-	-	S	-	-	-	competence protein
CIGNAPPK_01376	1.67e-100	-	-	-	S	ko:K07107	-	ko00000,ko01000	Thioesterase-like superfamily
CIGNAPPK_01379	0.0	-	3.1.6.1	-	P	ko:K01130	ko00140,ko00600,map00140,map00600	ko00000,ko00001,ko01000	Sulfatase
CIGNAPPK_01380	1.3e-143	-	-	-	-	-	-	-	-
CIGNAPPK_01381	9.08e-165	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
CIGNAPPK_01382	4.82e-178	tpiA	5.3.1.1	-	G	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000,ko04147	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
CIGNAPPK_01383	2.71e-300	-	2.1.1.176	-	J	ko:K03500	-	ko00000,ko01000,ko03009	16S rRNA methyltransferase RsmB/F
CIGNAPPK_01384	2.35e-114	-	3.1.6.8	-	P	ko:K01134	ko00600,ko04142,map00600,map04142	ko00000,ko00001,ko01000	COG3119 Arylsulfatase A
CIGNAPPK_01385	2.9e-316	argG	6.3.4.5	-	E	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	ko00000,ko00001,ko00002,ko01000,ko04147	Arginosuccinate synthase
CIGNAPPK_01387	2.79e-54	rpsN	-	-	J	ko:K02954	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIGNAPPK_01388	8.43e-59	-	-	-	S	-	-	-	Zinc ribbon domain
CIGNAPPK_01389	4.77e-310	-	-	-	S	-	-	-	PFAM CBS domain containing protein
CIGNAPPK_01390	5.92e-150	-	3.1.26.4	-	L	ko:K03470	ko03030,map03030	ko00000,ko00001,ko01000,ko03032	Ribonuclease HII
CIGNAPPK_01391	4.83e-82	-	-	-	L	ko:K07460	-	ko00000	Uncharacterised protein family UPF0102
CIGNAPPK_01393	2.27e-175	-	4.1.1.48	-	E	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Indole-3-glycerol phosphate synthase
CIGNAPPK_01394	1.38e-228	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
CIGNAPPK_01395	2.31e-156	-	-	-	S	-	-	-	3D domain
CIGNAPPK_01396	1.45e-149	nth	4.2.99.18	-	L	ko:K10773	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIGNAPPK_01397	9.91e-171	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
CIGNAPPK_01398	1.65e-113	aglS	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
CIGNAPPK_01399	4.52e-101	exbD2	-	-	U	ko:K03559	-	ko00000,ko02000	biopolymer transport protein
CIGNAPPK_01400	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_01401	3.31e-196	-	-	-	-	-	-	-	-
CIGNAPPK_01402	8.99e-277	-	-	-	K	-	-	-	sequence-specific DNA binding
CIGNAPPK_01403	0.0	-	-	-	J	ko:K08301	-	ko00000,ko01000,ko03009,ko03019	Ribonuclease E/G family
CIGNAPPK_01404	5.06e-236	-	-	-	D	ko:K03569	-	ko00000,ko02048,ko03036,ko04812	Actin
CIGNAPPK_01405	0.0	lacZ_17	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	beta-galactosidase activity
CIGNAPPK_01407	2.24e-263	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
CIGNAPPK_01409	1.3e-177	-	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	CobB/CobQ-like glutamine amidotransferase domain
CIGNAPPK_01410	0.0	purL	6.3.5.3	-	F	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
CIGNAPPK_01411	5.55e-116	-	-	-	-	-	-	-	-
CIGNAPPK_01412	1.89e-166	-	6.3.2.6	-	F	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	SAICAR synthetase
CIGNAPPK_01413	0.0	-	-	-	K	-	-	-	Transcription elongation factor, N-terminal
CIGNAPPK_01414	0.0	-	2.2.1.1	-	G	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CIGNAPPK_01415	3.46e-179	proB	2.7.2.11	-	E	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CIGNAPPK_01416	2.46e-307	proA	1.2.1.41	-	E	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CIGNAPPK_01417	1.34e-201	-	2.3.1.30	-	E	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	ko00000,ko00001,ko00002,ko01000	Serine acetyltransferase, N-terminal
CIGNAPPK_01418	1.06e-109	-	-	-	S	ko:K15977	-	ko00000	DoxX
CIGNAPPK_01419	2.76e-292	-	4.2.1.129, 5.4.99.17	-	I	ko:K06045	ko00909,ko01110,map00909,map01110	ko00000,ko00001,ko01000	PFAM Prenyltransferase squalene oxidase
CIGNAPPK_01420	4.7e-193	-	-	-	-	-	-	-	-
CIGNAPPK_01421	3.37e-224	-	5.3.1.13	-	M	ko:K06041	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	SIS domain
CIGNAPPK_01422	9.39e-183	-	-	-	H	-	-	-	ThiF family
CIGNAPPK_01423	8.92e-111	-	-	-	U	-	-	-	response to pH
CIGNAPPK_01424	1.74e-224	-	-	-	-	-	-	-	-
CIGNAPPK_01425	4.09e-218	-	-	-	I	-	-	-	alpha/beta hydrolase fold
CIGNAPPK_01427	0.0	-	-	-	G	-	-	-	Raffinose synthase or seed imbibition protein Sip1
CIGNAPPK_01428	5.15e-270	-	-	-	S	-	-	-	COGs COG4299 conserved
CIGNAPPK_01429	7.25e-153	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_01430	0.0	-	3.4.16.4	-	M	ko:K05515	ko00550,ko01501,map00550,map01501	ko00000,ko00001,ko01000,ko01011	Penicillin-binding Protein dimerisation domain
CIGNAPPK_01431	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01432	1.8e-218	-	-	-	C	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko03110	ATP synthase A chain
CIGNAPPK_01433	1.65e-11	-	-	-	S	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	PFAM H transporting two-sector ATPase C subunit
CIGNAPPK_01434	6.22e-78	atpF	-	-	C	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase B/B' CF(0)
CIGNAPPK_01435	6.46e-86	-	-	-	C	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	ATP synthase delta (OSCP) subunit
CIGNAPPK_01436	0.0	atpA	3.6.3.14	-	C	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIGNAPPK_01437	4.5e-201	atpG	-	-	C	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIGNAPPK_01438	0.0	atpD	3.6.3.14	-	C	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194,ko01000	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIGNAPPK_01439	1.24e-90	atpC	-	-	C	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	ko00000,ko00001,ko00002,ko00194	Produces ATP from ADP in the presence of a proton gradient across the membrane
CIGNAPPK_01440	1.38e-139	-	-	-	-	-	-	-	-
CIGNAPPK_01441	8.17e-124	sprT	-	-	K	-	-	-	SprT-like family
CIGNAPPK_01442	1.49e-275	-	-	-	S	-	-	-	COGs COG4299 conserved
CIGNAPPK_01443	2.94e-285	-	2.6.1.59	-	M	ko:K02805	-	ko00000,ko01000,ko01007	DegT/DnrJ/EryC1/StrS aminotransferase family
CIGNAPPK_01444	2.98e-115	flmH	2.3.1.57	-	J	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	ko00000,ko00001,ko00002,ko01000	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIGNAPPK_01445	1.95e-222	-	-	-	M	-	-	-	Glycosyl transferase family 2
CIGNAPPK_01446	1.08e-73	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
CIGNAPPK_01447	3.2e-76	-	-	-	P	ko:K03297,ko:K11741	-	ko00000,ko02000	Multidrug Resistance protein
CIGNAPPK_01450	0.0	-	2.6.1.62	-	H	ko:K00833	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class-III
CIGNAPPK_01451	1.77e-234	-	2.8.1.6	-	H	ko:K01012	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	Biotin and Thiamin Synthesis associated domain
CIGNAPPK_01452	0.0	-	-	-	P	-	-	-	Sulfatase
CIGNAPPK_01453	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
CIGNAPPK_01454	2.04e-293	-	-	-	O	ko:K09015	-	ko00000	Uncharacterized protein family (UPF0051)
CIGNAPPK_01455	0.0	-	-	-	O	ko:K09014	-	ko00000	Uncharacterized protein family (UPF0051)
CIGNAPPK_01456	1.02e-178	-	-	-	O	ko:K09013	-	ko00000,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_01457	6.78e-100	-	-	-	P	ko:K09825	-	ko00000,ko03000	Ferric uptake regulator family
CIGNAPPK_01458	2.14e-57	rpmA	-	-	J	ko:K02899	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L27 protein
CIGNAPPK_01459	1.93e-66	rplU	-	-	J	ko:K02888	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal prokaryotic L21 protein
CIGNAPPK_01460	3.34e-106	-	-	-	S	ko:K06925	-	ko00000,ko03016	Threonylcarbamoyl adenosine biosynthesis protein TsaE
CIGNAPPK_01461	3.73e-200	-	-	-	S	ko:K06889	-	ko00000	alpha beta
CIGNAPPK_01463	0.0	-	-	-	M	-	-	-	Parallel beta-helix repeats
CIGNAPPK_01464	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_01465	2.58e-225	-	-	-	S	-	-	-	Polyphosphate kinase 2 (PPK2)
CIGNAPPK_01467	1.36e-175	-	-	-	-	-	-	-	-
CIGNAPPK_01468	3.35e-131	-	-	-	L	-	-	-	Conserved hypothetical protein 95
CIGNAPPK_01469	1.18e-309	-	2.4.99.12, 2.4.99.13, 2.4.99.14, 2.4.99.15	GT30	M	ko:K02527	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)
CIGNAPPK_01470	1.98e-232	-	-	-	S	-	-	-	Aspartyl protease
CIGNAPPK_01471	3.37e-272	rsgA	3.1.3.100	-	S	ko:K06949	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000,ko03009	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
CIGNAPPK_01472	1.97e-159	-	6.3.2.5	-	H	ko:K21977	ko00770,map00770	ko00000,ko00001,ko00002,ko01000	DNA / pantothenate metabolism flavoprotein
CIGNAPPK_01473	3.38e-279	-	2.8.1.7	-	E	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	Aminotransferase class-V
CIGNAPPK_01474	6.51e-103	-	-	-	K	ko:K03826	-	ko00000,ko01000	acetyltransferase
CIGNAPPK_01475	2.48e-173	-	-	-	K	ko:K03436	-	ko00000,ko03000	DeoR C terminal sensor domain
CIGNAPPK_01476	0.0	-	-	-	L	-	-	-	Polyphosphate kinase 2 (PPK2)
CIGNAPPK_01477	0.0	-	-	-	S	-	-	-	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CIGNAPPK_01478	1.1e-257	-	-	-	M	-	-	-	Peptidase family M23
CIGNAPPK_01480	8.37e-126	-	4.1.1.36	-	H	ko:K01598	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Flavoprotein
CIGNAPPK_01481	1.31e-81	-	-	-	DJ	-	-	-	Addiction module toxin, RelE StbE family
CIGNAPPK_01482	2.34e-208	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
CIGNAPPK_01484	1.26e-139	-	-	-	K	ko:K03088	-	ko00000,ko03021	ECF sigma factor
CIGNAPPK_01485	0.0	-	2.4.2.14	-	F	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01002	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CIGNAPPK_01486	4.07e-246	-	6.3.3.1	-	F	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	AIR synthase related protein, N-terminal domain
CIGNAPPK_01487	7.5e-105	-	-	-	S	ko:K15977	-	ko00000	DoxX
CIGNAPPK_01488	9.94e-243	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
CIGNAPPK_01489	0.0	-	3.1.1.53	-	E	ko:K05970	-	ko00000,ko01000	Carbohydrate esterase, sialic acid-specific acetylesterase
CIGNAPPK_01490	1.84e-177	-	-	-	-	-	-	-	-
CIGNAPPK_01491	0.0	-	3.6.4.13	-	L	ko:K05592	ko03018,map03018	ko00000,ko00001,ko01000,ko03009,ko03019	DbpA RNA binding domain
CIGNAPPK_01492	0.0	-	-	-	P	ko:K01138	-	ko00000,ko01000	PA14 domain
CIGNAPPK_01493	4.72e-154	-	-	-	L	-	-	-	Membrane
CIGNAPPK_01496	0.0	-	-	-	E	-	-	-	lipolytic protein G-D-S-L family
CIGNAPPK_01497	1.85e-149	-	-	-	-	-	-	-	-
CIGNAPPK_01499	1.34e-109	ptsN	2.7.1.202	-	G	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	ko00000,ko00001,ko00002,ko01000,ko02000	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIGNAPPK_01500	0.0	-	-	-	P	ko:K03281	-	ko00000	Voltage gated chloride channel
CIGNAPPK_01501	2.47e-253	-	-	-	L	-	-	-	Transposase IS200 like
CIGNAPPK_01502	0.0	-	1.4.1.4	-	E	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	ko00000,ko00001,ko01000	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
CIGNAPPK_01503	3.35e-269	-	2.4.1.182	GT19	M	ko:K00748	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIGNAPPK_01504	3.89e-149	dedA	-	-	S	-	-	-	FtsZ-dependent cytokinesis
CIGNAPPK_01505	1.3e-116	-	-	-	S	-	-	-	nitrogen fixation
CIGNAPPK_01506	6.22e-74	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CIGNAPPK_01507	6.11e-76	-	-	-	S	-	-	-	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CIGNAPPK_01508	1.26e-112	-	-	-	CO	-	-	-	cell redox homeostasis
CIGNAPPK_01510	2.47e-179	-	-	-	-	-	-	-	-
CIGNAPPK_01512	0.0	-	-	-	S	-	-	-	Bacteriophage head to tail connecting protein
CIGNAPPK_01514	1.15e-143	-	-	-	-	-	-	-	-
CIGNAPPK_01515	3.45e-64	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CIGNAPPK_01517	5.87e-32	cas2	-	-	L	ko:K09951	-	ko00000,ko02048	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CIGNAPPK_01518	8.36e-119	cas1	-	-	L	ko:K15342	-	ko00000,ko02048,ko03400	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CIGNAPPK_01519	1.6e-57	cas4	3.1.12.1	-	L	ko:K07464	-	ko00000,ko01000,ko02048	crispr-associated protein cas4
CIGNAPPK_01520	1.48e-83	cas3	-	-	L	ko:K07012	-	ko00000,ko01000,ko02048	DEAD-like helicases superfamily
CIGNAPPK_01521	4.23e-108	-	-	-	S	ko:K19119	-	ko00000,ko02048	CRISPR-associated protein (Cas_Cas5)
CIGNAPPK_01522	1.64e-134	csd1	3.5.1.28	-	M	ko:K01447,ko:K17733,ko:K19117	-	ko00000,ko01000,ko01002,ko01011,ko02048	N-Acetylmuramoyl-L-alanine amidase
CIGNAPPK_01523	2.28e-118	csd2	-	-	L	ko:K19118	-	ko00000,ko02048	CRISPR-associated protein, Csd2 family
CIGNAPPK_01524	1.83e-284	-	-	-	S	-	-	-	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
CIGNAPPK_01525	0.0	-	1.2.1.88, 1.5.5.2	-	CE	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	ko00000,ko00001,ko01000,ko03000	Proline dehydrogenase
CIGNAPPK_01527	1.43e-45	-	-	-	S	-	-	-	R3H domain
CIGNAPPK_01528	0.0	-	1.11.1.6	-	P	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	ko00000,ko00001,ko00002,ko01000	Catalase
CIGNAPPK_01530	0.0	-	-	-	O	-	-	-	Cytochrome C assembly protein
CIGNAPPK_01531	1.08e-136	rbr	-	-	C	-	-	-	Rubrerythrin
CIGNAPPK_01532	7.6e-145	-	-	-	J	-	-	-	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIGNAPPK_01534	0.0	-	-	-	D	ko:K03466	-	ko00000,ko03036	Ftsk_gamma
CIGNAPPK_01535	5.68e-180	-	-	-	M	ko:K01991	ko02026,map02026	ko00000,ko00001,ko02000	polysaccharide export
CIGNAPPK_01536	0.0	gumC	-	-	DM	ko:K16554	ko05111,map05111	ko00000,ko00001,ko02000	PFAM lipopolysaccharide biosynthesis protein
CIGNAPPK_01537	1.11e-163	-	3.1.3.48	-	GM	ko:K01104	-	ko00000,ko01000	protein tyrosine phosphatase activity
CIGNAPPK_01538	5.64e-175	-	-	-	M	-	-	-	Bacterial sugar transferase
CIGNAPPK_01539	1.78e-166	wbyL	-	GT2	M	ko:K13002	-	ko00000,ko01000,ko01003,ko01005	transferase activity, transferring glycosyl groups
CIGNAPPK_01540	1.42e-121	-	-	-	S	-	-	-	Polysaccharide biosynthesis protein
CIGNAPPK_01541	2.56e-26	-	-	-	M	-	-	-	Glycosyltransferase like family 2
CIGNAPPK_01542	1.43e-64	-	-	-	H	-	-	-	Pfam:DUF1792
CIGNAPPK_01543	8e-27	-	-	-	S	-	-	-	Glycosyl transferase family 2
CIGNAPPK_01545	1.94e-120	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
CIGNAPPK_01546	1.19e-152	lsgC	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
CIGNAPPK_01547	8.1e-119	-	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
CIGNAPPK_01548	1.19e-17	-	2.3.1.79	-	S	ko:K00661	-	ko00000,ko01000	COG0110 Acetyltransferase (isoleucine patch superfamily)
CIGNAPPK_01549	2.72e-27	-	-	-	S	-	-	-	O-Antigen ligase
CIGNAPPK_01550	2.95e-108	-	-	-	M	-	-	-	Glycosyl transferases group 1
CIGNAPPK_01551	5.73e-125	-	-	-	M	-	-	-	Glycosyl transferases group 1
CIGNAPPK_01552	6.28e-30	-	-	-	S	-	-	-	Glycosyl transferase family 2
CIGNAPPK_01553	1.54e-66	-	-	-	S	ko:K03818	-	ko00000,ko01000	Bacterial transferase hexapeptide (six repeats)
CIGNAPPK_01554	9.15e-09	-	-	-	I	-	-	-	Psort location CytoplasmicMembrane, score
CIGNAPPK_01555	6.02e-103	-	-	-	M	-	-	-	PFAM glycosyl transferase family 2
CIGNAPPK_01556	0.0	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_01558	2.62e-285	-	-	-	S	-	-	-	very-long-chain-acyl-CoA dehydrogenase activity
CIGNAPPK_01559	1.19e-92	-	5.1.3.29	-	G	ko:K02431	-	ko00000,ko01000	RbsD / FucU transport protein family
CIGNAPPK_01560	7.15e-299	-	4.4.1.8	-	E	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	ko00000,ko00001,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_01561	0.0	-	6.1.1.10	-	J	ko:K01874	ko00450,ko00970,map00450,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
CIGNAPPK_01562	0.0	menD	2.2.1.9	-	H	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CIGNAPPK_01564	2.57e-315	-	1.1.1.40	-	C	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Malic enzyme, NAD binding domain
CIGNAPPK_01565	0.0	-	-	-	I	ko:K06889,ko:K09914	-	ko00000	PFAM Prenyltransferase squalene oxidase
CIGNAPPK_01566	3.28e-228	exsH	3.2.1.178, 3.2.1.18, 3.2.1.52	GH16,GH20,GH33	G	ko:K01186,ko:K12373,ko:K20830	ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko02042,ko03110	xyloglucan:xyloglucosyl transferase activity
CIGNAPPK_01567	5.88e-256	-	3.2.1.52	-	G	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	ko00000,ko00001,ko00002,ko01000	Glycosyl hydrolase family 3 N terminal domain
CIGNAPPK_01568	3.23e-128	pyrE	2.4.2.10	-	F	ko:K00762	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIGNAPPK_01569	3.06e-157	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_01570	0.0	yidC	-	-	O	ko:K03217,ko:K06872	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	serine-type endopeptidase activity
CIGNAPPK_01571	9.22e-268	-	-	-	H	-	-	-	Elongator protein 3, MiaB family, Radical SAM
CIGNAPPK_01573	2.56e-309	-	6.1.1.11	-	J	ko:K01875	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Seryl-tRNA synthetase N-terminal domain
CIGNAPPK_01574	5.79e-274	-	-	-	E	-	-	-	Alcohol dehydrogenase GroES-like domain
CIGNAPPK_01576	4.08e-215	-	3.5.1.53	-	K	ko:K12251	ko00330,ko01100,map00330,map01100	ko00000,ko00001,ko01000	Carbon-nitrogen hydrolase
CIGNAPPK_01577	3.82e-231	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
CIGNAPPK_01578	3.22e-215	-	-	-	S	-	-	-	Protein of unknown function DUF58
CIGNAPPK_01579	2.63e-135	-	3.1.1.29	-	J	ko:K01056	-	ko00000,ko01000,ko03012	Peptidyl-tRNA hydrolase
CIGNAPPK_01580	0.0	-	-	-	M	-	-	-	Transglycosylase
CIGNAPPK_01581	0.0	-	3.4.24.3	-	NU	ko:K01387	-	ko00000,ko01000,ko01002,ko02042	translation initiation factor activity
CIGNAPPK_01582	0.0	-	-	-	H	-	-	-	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIGNAPPK_01584	0.0	purA	6.3.4.4	-	F	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIGNAPPK_01586	0.0	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
CIGNAPPK_01587	6.94e-298	-	1.12.99.6	-	C	ko:K06282	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	NiFe/NiFeSe hydrogenase small subunit C-terminal
CIGNAPPK_01588	0.0	-	1.12.99.6	-	C	ko:K06281	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nickel-dependent hydrogenase
CIGNAPPK_01589	9.22e-290	hyaC	-	-	C	ko:K03620	ko02020,map02020	ko00000,ko00001	Prokaryotic cytochrome b561
CIGNAPPK_01590	3.4e-126	-	-	-	C	ko:K03605	-	ko00000,ko01000,ko01002	Hydrogenase maturation protease
CIGNAPPK_01591	8.53e-76	-	-	-	C	ko:K04651	-	ko00000,ko03110	Hydrogenase/urease nickel incorporation, metallochaperone, hypA
CIGNAPPK_01593	1.37e-86	-	-	-	S	ko:K09940	-	ko00000	Domain of unknown function (DUF4870)
CIGNAPPK_01594	4.16e-178	-	-	-	M	-	-	-	NLP P60 protein
CIGNAPPK_01595	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycosyl hydrolase family 20, domain 2
CIGNAPPK_01596	3.85e-151	-	1.5.1.34	-	C	ko:K10679	ko00633,ko01120,map00633,map01120	ko00000,ko00001,ko01000	Nitroreductase family
CIGNAPPK_01597	5.22e-255	-	2.6.1.9	-	E	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	Aminotransferase class I and II
CIGNAPPK_01601	1.13e-218	-	-	-	S	ko:K11941	-	ko00000,ko01000	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_01602	0.0	-	4.2.1.2	-	C	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible hydration of fumarate to (S)- malate
CIGNAPPK_01604	1.03e-105	-	4.1.2.50, 4.2.3.12	-	H	ko:K01737	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000,ko03016	6-pyruvoyl tetrahydropterin synthase
CIGNAPPK_01606	0.0	-	3.2.1.52	GH20	G	ko:K01207,ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko01501,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map01501,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_01607	1.47e-302	ffh	3.6.5.4	-	U	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko01000,ko02044	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIGNAPPK_01608	3.4e-227	-	2.5.1.72	-	H	ko:K03517	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate synthetase A protein
CIGNAPPK_01609	5.01e-255	-	-	-	S	-	-	-	Putative S-adenosyl-L-methionine-dependent methyltransferase
CIGNAPPK_01610	0.0	rpoC	2.7.7.6	-	K	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIGNAPPK_01612	3.69e-64	rplL	-	-	J	ko:K02935	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
CIGNAPPK_01613	9.92e-110	rplJ	-	-	J	ko:K02864	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIGNAPPK_01614	1.74e-156	rplA	-	-	J	ko:K02863	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
CIGNAPPK_01615	2.58e-93	rplK	-	-	J	ko:K02867	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CIGNAPPK_01616	6.29e-135	nusG	-	-	K	ko:K02601	-	ko00000,ko03009,ko03021	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.
CIGNAPPK_01617	3.61e-46	-	-	-	U	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	SecE/Sec61-gamma subunits of protein translocation complex
CIGNAPPK_01619	9.94e-287	tuf	-	-	J	ko:K02358	-	ko00000,ko03012,ko03029,ko04147	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIGNAPPK_01621	2.49e-256	tsaD	2.3.1.234	-	O	ko:K01409	-	ko00000,ko01000,ko03016	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIGNAPPK_01622	0.0	clpX	-	-	O	ko:K03544	ko04112,map04112	ko00000,ko00001,ko03110	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIGNAPPK_01623	2.5e-153	-	3.4.21.92	-	OU	ko:K01358	ko04112,ko04212,map04112,map04212	ko00000,ko00001,ko01000,ko01002	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
CIGNAPPK_01624	9.77e-281	tig	-	-	O	ko:K03545	-	ko00000	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
CIGNAPPK_01625	0.0	-	-	-	M	ko:K07277	-	ko00000,ko02000,ko03029	Surface antigen
CIGNAPPK_01626	4.84e-155	-	1.14.11.27	-	P	ko:K10277	-	ko00000,ko01000,ko03036	peptidyl-arginine hydroxylation
CIGNAPPK_01627	2.6e-231	-	1.5.1.20	-	E	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	ko00000,ko00001,ko00002,ko01000	Methylenetetrahydrofolate reductase
CIGNAPPK_01628	2.38e-169	-	-	-	CO	-	-	-	Protein conserved in bacteria
CIGNAPPK_01630	1.46e-147	-	-	-	K	-	-	-	Bacterial regulatory proteins, tetR family
CIGNAPPK_01631	0.0	-	-	-	P	ko:K07239	-	ko00000	AcrB/AcrD/AcrF family
CIGNAPPK_01632	1.96e-297	czcB	-	-	M	ko:K15727	-	ko00000,ko02000	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIGNAPPK_01633	7.45e-296	-	-	-	MU	ko:K15725	-	ko00000,ko02000	efflux transmembrane transporter activity
CIGNAPPK_01635	2.13e-204	-	-	-	G	ko:K06867,ko:K07001	-	ko00000	response to abiotic stimulus
CIGNAPPK_01636	0.0	-	-	-	E	-	-	-	PFAM major facilitator superfamily MFS_1
CIGNAPPK_01639	1.66e-215	-	-	-	KQ	-	-	-	Hypothetical methyltransferase
CIGNAPPK_01640	2.18e-290	metK	2.5.1.6	-	H	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIGNAPPK_01641	0.0	ahcY	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIGNAPPK_01642	1.22e-249	rgpB	-	-	M	-	-	-	transferase activity, transferring glycosyl groups
CIGNAPPK_01643	1.87e-248	-	-	-	-	-	-	-	-
CIGNAPPK_01644	0.0	-	-	-	H	-	-	-	Flavin containing amine oxidoreductase
CIGNAPPK_01645	7.12e-226	-	-	-	-	-	-	-	-
CIGNAPPK_01646	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
CIGNAPPK_01647	0.0	-	3.6.4.12	-	L	ko:K03654	ko03018,map03018	ko00000,ko00001,ko01000,ko03400	RecQ zinc-binding
CIGNAPPK_01649	2.05e-299	-	-	-	M	-	-	-	Glycosyl transferases group 1
CIGNAPPK_01650	9.76e-258	-	-	-	S	-	-	-	Glycoside-hydrolase family GH114
CIGNAPPK_01651	0.0	-	1.4.3.16	-	H	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
CIGNAPPK_01652	2.86e-133	-	2.1.1.185	-	J	ko:K03218	-	ko00000,ko01000,ko03009	SpoU rRNA Methylase family
CIGNAPPK_01653	2.64e-205	-	3.1.1.53	-	L	ko:K03547,ko:K05970	-	ko00000,ko01000,ko03400	3'-5' exonuclease activity
CIGNAPPK_01654	9.94e-90	-	-	-	K	-	-	-	Helix-turn-helix diphteria tox regulatory element
CIGNAPPK_01655	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
CIGNAPPK_01657	2.83e-303	-	-	-	M	ko:K07267	-	ko00000,ko02000	wide pore channel activity
CIGNAPPK_01660	0.0	-	-	-	P	ko:K04759	-	ko00000,ko02000	Ferrous iron transport protein B C terminus
CIGNAPPK_01661	4.02e-48	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
CIGNAPPK_01662	2.48e-40	feoA	-	-	P	ko:K04758	-	ko00000,ko02000	iron ion homeostasis
CIGNAPPK_01663	0.0	-	1.11.1.5	-	P	ko:K00428	-	ko00000,ko01000	Di-haem cytochrome c peroxidase
CIGNAPPK_01664	1.56e-228	lipA	2.8.1.8	-	H	ko:K03644	ko00785,ko01100,map00785,map01100	ko00000,ko00001,ko01000	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIGNAPPK_01665	1.1e-131	tadA	3.5.4.33	-	FJ	ko:K11991	-	ko00000,ko01000,ko03016	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
CIGNAPPK_01666	3.46e-242	-	2.7.1.2	-	GK	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	ROK family
CIGNAPPK_01667	0.0	-	-	-	P	-	-	-	E1-E2 ATPase
CIGNAPPK_01668	0.0	-	-	-	K	ko:K03628	ko03018,map03018	ko00000,ko00001,ko03019,ko03021	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIGNAPPK_01669	1.85e-142	coaE	2.7.1.24	-	H	ko:K00859	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIGNAPPK_01670	0.0	-	-	-	NU	ko:K02453	ko03070,ko05111,map03070,map05111	ko00000,ko00001,ko00002,ko02044	Bacterial type II and III secretion system protein
CIGNAPPK_01671	2.27e-245	-	-	-	-	-	-	-	-
CIGNAPPK_01672	1.06e-208	-	-	-	-	-	-	-	-
CIGNAPPK_01673	0.0	-	-	-	NU	-	-	-	Type IV pilus assembly protein PilM;
CIGNAPPK_01674	2.8e-169	-	-	-	-	-	-	-	-
CIGNAPPK_01675	1.15e-255	-	-	-	G	-	-	-	M42 glutamyl aminopeptidase
CIGNAPPK_01676	8.4e-260	lgt	-	-	M	ko:K13292	-	ko00000,ko01000	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIGNAPPK_01677	1.19e-156	-	-	-	S	-	-	-	Protein of unknown function (DUF3313)
CIGNAPPK_01678	1.68e-313	-	3.4.11.9	-	E	ko:K01262	-	ko00000,ko01000,ko01002	Aminopeptidase P, N-terminal domain
CIGNAPPK_01679	3.88e-207	hisG	2.4.2.17	-	E	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	ATP phosphoribosyltransferase
CIGNAPPK_01680	2.09e-10	-	-	-	S	-	-	-	Mitochondrial domain of unknown function (DUF1713)
CIGNAPPK_01681	8.6e-291	-	2.7.13.3	-	T	ko:K07636	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	His Kinase A (phosphoacceptor) domain
CIGNAPPK_01682	6.89e-168	-	-	-	T	ko:K07657	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
CIGNAPPK_01683	0.0	-	4.2.1.9	-	EG	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Dehydratase family
CIGNAPPK_01684	0.0	-	-	-	T	-	-	-	pathogenesis
CIGNAPPK_01685	1.64e-267	xerD1	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
CIGNAPPK_01686	1.39e-206	-	3.2.2.27	-	L	ko:K21929	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	Uracil DNA glycosylase superfamily
CIGNAPPK_01687	1.4e-287	-	4.1.99.19	-	H	ko:K03150	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko01000	Biotin and Thiamin Synthesis associated domain
CIGNAPPK_01688	0.0	-	-	-	M	-	-	-	Sulfatase
CIGNAPPK_01689	3.09e-290	-	-	-	-	-	-	-	-
CIGNAPPK_01690	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
CIGNAPPK_01691	0.0	-	-	-	S	-	-	-	Protein of unknown function (DUF2851)
CIGNAPPK_01692	1.29e-118	-	-	-	T	-	-	-	STAS domain
CIGNAPPK_01693	0.0	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
CIGNAPPK_01694	0.0	-	-	-	I	-	-	-	Prenyltransferase and squalene oxidase repeat
CIGNAPPK_01695	1.26e-247	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
CIGNAPPK_01696	0.0	-	2.1.1.182	-	IJ	ko:K02528	-	ko00000,ko01000,ko03009	Ribosomal RNA adenine dimethylases
CIGNAPPK_01697	2.93e-102	-	-	-	-	-	-	-	-
CIGNAPPK_01698	9.86e-54	-	-	-	-	-	-	-	-
CIGNAPPK_01699	5.51e-122	-	-	-	-	-	-	-	-
CIGNAPPK_01700	3.53e-300	-	-	-	V	ko:K03327	-	ko00000,ko02000	drug transmembrane transporter activity
CIGNAPPK_01701	0.0	-	-	-	P	-	-	-	Cation transport protein
CIGNAPPK_01704	9.28e-149	-	-	-	M	ko:K17733	-	ko00000,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
CIGNAPPK_01710	1.3e-265	-	-	GT4	M	ko:K16703	-	ko00000,ko01000,ko01003	transferase activity, transferring glycosyl groups
CIGNAPPK_01712	0.0	-	-	-	M	-	-	-	pathogenesis
CIGNAPPK_01717	0.0	-	-	-	O	ko:K03695	ko04213,map04213	ko00000,ko00001,ko03110	C-terminal, D2-small domain, of ClpB protein
CIGNAPPK_01718	1.9e-232	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CIGNAPPK_01719	2.5e-79	-	-	-	S	-	-	-	PFAM Cupin 2 conserved barrel domain protein
CIGNAPPK_01720	1.12e-129	-	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CIGNAPPK_01721	0.0	-	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CIGNAPPK_01722	0.0	-	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CIGNAPPK_01724	2.4e-167	-	-	-	T	ko:K07667	ko02020,ko02024,map02020,map02024	ko00000,ko00001,ko00002,ko02022	Transcriptional regulatory protein, C terminal
CIGNAPPK_01725	0.0	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
CIGNAPPK_01727	4.92e-06	-	-	-	-	-	-	-	-
CIGNAPPK_01728	0.0	-	3.2.1.23	-	G	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Beta galactosidase small chain
CIGNAPPK_01729	1.78e-266	-	-	-	S	-	-	-	Uncharacterized protein conserved in bacteria (DUF2219)
CIGNAPPK_01730	4.37e-203	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
CIGNAPPK_01731	2.63e-84	-	-	-	M	-	-	-	Lysin motif
CIGNAPPK_01732	1.24e-179	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_01733	0.0	-	-	-	V	-	-	-	MatE
CIGNAPPK_01734	4.46e-254	-	3.3.1.1	-	H	ko:K01251	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	adenosylhomocysteinase activity
CIGNAPPK_01736	1.02e-258	-	2.7.7.7	-	L	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
CIGNAPPK_01738	1.63e-156	-	-	-	M	-	-	-	Bacterial transferase hexapeptide (six repeats)
CIGNAPPK_01739	2.16e-264	-	1.1.1.193, 3.5.4.26	-	H	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	ko00000,ko00001,ko00002,ko01000	RibD C-terminal domain
CIGNAPPK_01740	0.0	gidA	-	-	D	ko:K03495	-	ko00000,ko03016,ko03036	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
CIGNAPPK_01741	7.08e-272	-	2.7.7.7	-	L	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III, delta subunit
CIGNAPPK_01742	0.0	-	-	-	O	-	-	-	Trypsin
CIGNAPPK_01743	7.97e-108	-	2.2.1.6	-	E	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	ACT domain
CIGNAPPK_01744	0.0	-	3.6.4.13	-	L	ko:K03578	-	ko00000,ko01000	Oligonucleotide/oligosaccharide-binding (OB)-fold
CIGNAPPK_01745	3.52e-161	-	-	-	P	ko:K03499	-	ko00000,ko02000	TrkA-N domain
CIGNAPPK_01746	0.0	-	-	-	P	-	-	-	Cation transport protein
CIGNAPPK_01747	8.16e-209	-	-	-	S	-	-	-	Protein of unknown function (DUF1524)
CIGNAPPK_01748	4.33e-17	-	-	-	K	-	-	-	Helix-turn-helix domain
CIGNAPPK_01750	7.4e-178	hisF	-	-	E	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	ko00000,ko00001,ko00002,ko01000	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
CIGNAPPK_01751	0.0	-	-	-	G	-	-	-	Domain of unknown function (DUF4091)
CIGNAPPK_01752	3.2e-70	-	-	-	K	-	-	-	HxlR-like helix-turn-helix
CIGNAPPK_01753	1.32e-101	manC	-	-	S	-	-	-	Cupin domain
CIGNAPPK_01754	0.0	-	1.2.7.1	-	C	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	br01601,ko00000,ko00001,ko00002,ko01000	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIGNAPPK_01755	0.0	lysS	6.1.1.6	-	J	ko:K04567	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class II (D, K and N)
CIGNAPPK_01756	1.02e-187	pppL	3.1.3.16	-	T	ko:K20074	-	ko00000,ko01000,ko01009	protein serine/threonine phosphatase activity
CIGNAPPK_01757	4.34e-152	-	2.3.1.15	-	I	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko01004	Glycerol-3-phosphate acyltransferase
CIGNAPPK_01758	1.34e-234	gpsA	1.1.1.94	-	C	ko:K00057	ko00564,ko01110,map00564,map01110	ko00000,ko00001,ko01000	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
CIGNAPPK_01759	8.62e-102	-	-	-	-	-	-	-	-
CIGNAPPK_01761	6.95e-264	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
CIGNAPPK_01762	1.32e-313	pqqE	-	-	C	ko:K06139	-	ko00000	SMART Elongator protein 3 MiaB NifB
CIGNAPPK_01763	0.0	metY	2.5.1.49	-	E	ko:K01740	ko00270,ko01100,map00270,map01100	ko00000,ko00001,ko01000	Cys/Met metabolism PLP-dependent enzyme
CIGNAPPK_01764	5.93e-05	-	-	-	-	-	-	-	-
CIGNAPPK_01765	0.0	-	-	-	O	ko:K07391	-	ko00000	Magnesium chelatase, subunit ChlI C-terminal
CIGNAPPK_01766	2.36e-209	-	-	-	S	-	-	-	Rhomboid family
CIGNAPPK_01767	2.63e-269	-	-	-	E	-	-	-	FAD dependent oxidoreductase
CIGNAPPK_01768	2.64e-267	leuB	1.1.1.85	-	CE	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	br01601,ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
CIGNAPPK_01771	0.0	-	-	-	S	-	-	-	Phosphoadenosine phosphosulfate reductase
CIGNAPPK_01772	2e-120	-	-	-	K	-	-	-	ParB domain protein nuclease
CIGNAPPK_01775	9.17e-116	-	-	-	L	-	-	-	Staphylococcal nuclease homologues
CIGNAPPK_01776	5.62e-247	-	-	-	M	-	-	-	Alginate lyase
CIGNAPPK_01777	1.79e-206	-	-	-	IQ	-	-	-	KR domain
CIGNAPPK_01780	7.17e-104	yciA	-	-	I	ko:K10806	ko01040,map01040	ko00000,ko00001,ko01000,ko01004	acyl-coa hydrolase
CIGNAPPK_01781	1.42e-315	hsrA	-	-	EGP	-	-	-	Major facilitator Superfamily
CIGNAPPK_01782	1.72e-290	-	-	-	I	-	-	-	transferase activity, transferring acyl groups other than amino-acyl groups
CIGNAPPK_01783	3.4e-242	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
CIGNAPPK_01784	2.62e-180	-	-	-	CH	-	-	-	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
CIGNAPPK_01785	0.0	-	3.2.1.23	-	G	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	ko00000,ko00001,ko01000	Glycosyl hydrolases family 35
CIGNAPPK_01786	8.77e-158	-	-	-	C	-	-	-	Nitroreductase family
CIGNAPPK_01787	0.0	-	-	-	E	-	-	-	Transglutaminase-like
CIGNAPPK_01788	6.8e-111	-	-	-	S	-	-	-	Bacterial transferase hexapeptide (six repeats)
CIGNAPPK_01789	6.56e-112	-	-	-	S	ko:K08999	-	ko00000	Bifunctional nuclease
CIGNAPPK_01791	0.0	-	-	-	P	-	-	-	Citrate transporter
CIGNAPPK_01793	2.8e-258	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
CIGNAPPK_01794	0.0	-	-	-	I	-	-	-	Acyltransferase family
CIGNAPPK_01795	2.57e-253	-	-	-	S	-	-	-	Glycosyltransferase family 10 (fucosyltransferase) C-term
CIGNAPPK_01796	5.24e-312	-	-	-	M	-	-	-	Glycosyl transferases group 1
CIGNAPPK_01797	7.27e-205	-	-	-	-	-	-	-	-
CIGNAPPK_01798	4.05e-290	-	-	-	M	-	-	-	Glycosyltransferase like family 2
CIGNAPPK_01799	1.31e-244	-	5.1.3.20	-	M	ko:K03274	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01005	3-beta hydroxysteroid dehydrogenase/isomerase family
CIGNAPPK_01800	5.25e-233	-	-	GT9	M	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	ADP-heptose-lipopolysaccharide heptosyltransferase activity
CIGNAPPK_01801	5.82e-250	-	-	-	S	-	-	-	Glycosyltransferase like family 2
CIGNAPPK_01802	3.88e-245	-	-	-	H	-	-	-	PFAM glycosyl transferase family 8
CIGNAPPK_01803	5.56e-212	lpxG	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase
CIGNAPPK_01805	2.54e-242	-	3.1.13.3, 3.1.3.7	-	S	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko01000,ko03400	DHHA1 domain
CIGNAPPK_01806	9.36e-171	truB	5.4.99.25	-	J	ko:K03177	-	ko00000,ko01000,ko03016	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIGNAPPK_01807	1.88e-224	-	2.7.1.26, 2.7.7.2	-	H	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Riboflavin kinase
CIGNAPPK_01808	9e-65	panD	4.1.1.11	-	H	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CIGNAPPK_01809	5.95e-89	-	-	-	U	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Preprotein translocase SecG subunit
CIGNAPPK_01810	1.15e-151	-	-	-	NU	-	-	-	Prokaryotic N-terminal methylation motif
CIGNAPPK_01811	1.19e-256	-	2.5.1.54	-	E	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	ko00000,ko00001,ko00002,ko01000	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CIGNAPPK_01812	3.17e-129	-	-	-	-	-	-	-	-
CIGNAPPK_01813	5.05e-233	-	-	-	S	ko:K07088	-	ko00000	Membrane transport protein
CIGNAPPK_01814	5.9e-182	-	-	-	S	-	-	-	NYN domain
CIGNAPPK_01815	5.5e-154	ppaX_1	3.1.3.18, 3.6.1.1	-	S	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	glycolate biosynthetic process
CIGNAPPK_01816	1.58e-138	-	-	-	S	-	-	-	Maltose acetyltransferase
CIGNAPPK_01817	0.0	-	6.3.5.2	-	F	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	ko00000,ko00001,ko00002,ko01000,ko01002	GMP synthase C terminal domain
CIGNAPPK_01818	0.0	-	1.1.1.205	-	F	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	IMP dehydrogenase / GMP reductase domain
CIGNAPPK_01819	3.5e-121	-	3.1.3.48	-	T	ko:K01104	-	ko00000,ko01000	Low molecular weight phosphatase family
CIGNAPPK_01833	9.11e-67	-	-	-	KT	-	-	-	Peptidase S24-like
CIGNAPPK_01835	4.93e-64	-	-	-	F	-	-	-	acetyltransferase
CIGNAPPK_01836	4.71e-33	-	-	-	M	-	-	-	lytic transglycosylase activity
CIGNAPPK_01842	5.63e-177	-	-	-	O	-	-	-	Trypsin
CIGNAPPK_01843	4.04e-240	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
CIGNAPPK_01844	1.03e-201	-	-	-	-	-	-	-	-
CIGNAPPK_01845	0.0	-	-	-	S	-	-	-	Sulfatase-modifying factor enzyme 1
CIGNAPPK_01846	4.53e-283	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_01848	2.63e-10	-	-	-	-	-	-	-	-
CIGNAPPK_01850	8.23e-62	gatC	6.3.5.6, 6.3.5.7	-	J	ko:K02435	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIGNAPPK_01851	0.0	gatA	6.3.5.6, 6.3.5.7	-	J	ko:K02433	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
CIGNAPPK_01852	2.48e-228	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
CIGNAPPK_01853	1.26e-210	-	-	-	S	-	-	-	Protein of unknown function DUF58
CIGNAPPK_01854	8.06e-134	-	-	-	-	-	-	-	-
CIGNAPPK_01855	2.3e-229	-	-	-	S	-	-	-	Protein of unknown function (DUF1194)
CIGNAPPK_01857	8.51e-42	-	-	-	S	ko:K07114	-	ko00000,ko02000	von Willebrand factor (vWF) type A domain
CIGNAPPK_01858	0.0	-	-	-	S	-	-	-	Oxygen tolerance
CIGNAPPK_01859	1.16e-205	yeaE	-	-	S	-	-	-	aldo-keto reductase (NADP) activity
CIGNAPPK_01860	0.0	-	6.1.1.14	-	J	ko:K01880	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Anticodon binding domain
CIGNAPPK_01861	3.7e-156	-	-	-	S	-	-	-	DUF218 domain
CIGNAPPK_01862	1.93e-209	-	-	-	S	-	-	-	CAAX protease self-immunity
CIGNAPPK_01863	1.59e-286	-	-	-	E	ko:K10907	-	ko00000,ko01000,ko01007	Cys/Met metabolism PLP-dependent enzyme
CIGNAPPK_01864	8.26e-106	-	-	-	K	-	-	-	Lrp/AsnC ligand binding domain
CIGNAPPK_01865	0.0	-	-	-	L	-	-	-	SNF2 family N-terminal domain
CIGNAPPK_01866	8.46e-84	-	-	-	P	ko:K06195	-	ko00000	ApaG domain
CIGNAPPK_01867	2.23e-204	-	-	-	-	-	-	-	-
CIGNAPPK_01868	0.0	-	-	-	M	-	-	-	Glycosyl transferase family group 2
CIGNAPPK_01869	2.03e-190	-	-	-	S	-	-	-	L,D-transpeptidase catalytic domain
CIGNAPPK_01870	1.88e-135	-	-	-	K	ko:K07735	-	ko00000,ko03000	Uncharacterized ACR, COG1678
CIGNAPPK_01871	1.02e-163	-	-	-	S	ko:K06997	-	ko00000	Alanine racemase, N-terminal domain
CIGNAPPK_01872	0.0	-	-	-	S	-	-	-	50S ribosome-binding GTPase
CIGNAPPK_01873	4.75e-138	-	6.3.3.2	-	H	ko:K01934	ko00670,ko01100,map00670,map01100	ko00000,ko00001,ko01000	5-formyltetrahydrofolate cyclo-ligase family
CIGNAPPK_01874	8.83e-209	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_01875	0.0	-	-	-	E	-	-	-	Peptidase dimerisation domain
CIGNAPPK_01876	3.12e-223	hprK	-	-	T	ko:K06023	-	ko00000,ko01000	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
CIGNAPPK_01877	8.72e-53	-	-	-	G	ko:K11189	-	ko00000,ko02000	PTS HPr component phosphorylation site
CIGNAPPK_01878	0.0	-	2.7.3.9	-	G	ko:K08483	ko02060,map02060	ko00000,ko00001,ko01000,ko02000	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIGNAPPK_01879	0.0	-	-	-	P	-	-	-	Sulfatase
CIGNAPPK_01880	1.64e-223	-	2.1.3.3	-	E	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIGNAPPK_01881	5.06e-94	-	-	-	S	ko:K02426	-	ko00000	Fe-S metabolism associated domain
CIGNAPPK_01883	0.0	-	2.4.1.18	CBM48,GH13	G	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	ko00000,ko00001,ko00002,ko01000,ko04147	Alpha amylase, C-terminal all-beta domain
CIGNAPPK_01884	2.06e-262	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
CIGNAPPK_01885	0.0	cobD	2.6.1.9, 2.7.7.74, 4.1.1.81	-	M	ko:K00817,ko:K04720,ko:K07281	ko00340,ko00350,ko00360,ko00400,ko00401,ko00562,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00562,map00860,map00960,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000,ko01007	nucleotidyl transferase
CIGNAPPK_01886	7.52e-266	odh	1.5.1.28	-	I	ko:K04940	-	ko00000,ko01000	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIGNAPPK_01887	0.0	-	2.7.7.15	-	H	ko:K00968	ko00440,ko00564,ko01100,ko05231,map00440,map00564,map01100,map05231	ko00000,ko00001,ko00002,ko01000	Oxidoreductase family, NAD-binding Rossmann fold
CIGNAPPK_01888	5.99e-225	-	-	-	M	ko:K07271	-	ko00000,ko01000	LICD family
CIGNAPPK_01889	9.47e-130	-	-	-	S	-	-	-	protein trimerization
CIGNAPPK_01891	7.48e-183	-	2.1.1.144, 2.1.1.197	-	FG	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko00002,ko01000	trans-aconitate 2-methyltransferase activity
CIGNAPPK_01892	0.0	-	2.7.7.9	-	G	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	ko00000,ko00001,ko00002,ko01000	UTP--glucose-1-phosphate uridylyltransferase
CIGNAPPK_01893	8.27e-124	-	-	-	-	-	-	-	-
CIGNAPPK_01894	3.22e-63	-	-	-	J	-	-	-	RF-1 domain
CIGNAPPK_01895	1.79e-122	coaD	2.7.7.3	-	H	ko:K00954	ko00770,ko01100,map00770,map01100	ko00000,ko00001,ko00002,ko01000	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIGNAPPK_01896	2.13e-275	dxr	1.1.1.267	-	I	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
CIGNAPPK_01897	1.15e-300	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
CIGNAPPK_01898	4.34e-48	-	-	-	K	ko:K18566	ko00332,ko01130,map00332,map01130	ko00000,ko00001,ko01000	acetyltransferase
CIGNAPPK_01899	1.15e-146	-	-	-	J	ko:K02520	-	ko00000,ko03012,ko03029	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CIGNAPPK_01900	0.0	thrS	6.1.1.3	-	J	ko:K01868	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIGNAPPK_01902	4.89e-237	-	4.2.1.24	-	H	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	ko00000,ko00001,ko00002,ko01000,ko04147	Delta-aminolevulinic acid dehydratase
CIGNAPPK_01904	2.04e-160	-	-	-	T	-	-	-	Transcriptional regulatory protein, C terminal
CIGNAPPK_01905	0.0	-	-	-	T	-	-	-	His Kinase A (phosphoacceptor) domain
CIGNAPPK_01906	5.99e-231	-	4.1.1.35	-	M	ko:K08678	ko00520,ko01100,map00520,map01100	ko00000,ko00001,ko00002,ko01000	3-beta hydroxysteroid dehydrogenase/isomerase family
CIGNAPPK_01907	3.71e-184	-	-	-	I	-	-	-	Acyl-ACP thioesterase
CIGNAPPK_01909	5.88e-277	-	-	-	O	-	-	-	Domain present in PSD-95, Dlg, and ZO-1/2.
CIGNAPPK_01910	1.58e-239	-	-	-	O	-	-	-	Trypsin-like peptidase domain
CIGNAPPK_01911	0.0	-	2.4.1.129, 3.4.16.4	GT51	M	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	ko00000,ko00001,ko01000,ko01003,ko01011	Transglycosylase
CIGNAPPK_01912	2.44e-285	-	-	-	S	ko:K09760	-	ko00000	RmuC family
CIGNAPPK_01913	2.32e-170	-	3.1.3.18	-	S	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	ko00000,ko00001,ko01000	HAD-hyrolase-like
CIGNAPPK_01914	1.25e-132	-	2.3.1.129	-	M	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	ko00000,ko00001,ko00002,ko01000,ko01005	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIGNAPPK_01915	4.56e-209	-	-	-	S	-	-	-	RDD family
CIGNAPPK_01916	0.0	-	-	-	M	ko:K09808	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	MacB-like periplasmic core domain
CIGNAPPK_01917	2.29e-208	-	3.5.2.6	-	V	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	ko00000,ko00001,ko00002,ko01000,ko01504	Beta-lactamase enzyme family
CIGNAPPK_01918	2.27e-90	-	-	-	S	ko:K09793	-	ko00000	Protein of unknown function (DUF456)
CIGNAPPK_01919	9.7e-58	-	-	-	S	-	-	-	Psort location CytoplasmicMembrane, score
CIGNAPPK_01920	0.0	-	3.2.1.51	GH95	G	ko:K15923	ko00511,map00511	ko00000,ko00001,ko01000	Glycosyl hydrolase family 65, N-terminal domain
CIGNAPPK_01921	1.55e-258	-	-	-	S	-	-	-	Peptidase family M28
CIGNAPPK_01922	4.26e-250	-	-	-	I	-	-	-	alpha/beta hydrolase fold
CIGNAPPK_01923	0.0	ileS	6.1.1.5	-	J	ko:K01870	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CIGNAPPK_01924	1.76e-186	lspA	3.4.23.36	-	MU	ko:K03101	ko03060,map03060	ko00000,ko00001,ko01000,ko01002	Signal peptidase (SPase) II
CIGNAPPK_01925	4.84e-152	-	-	-	S	-	-	-	Protein of unknown function (DUF1573)
CIGNAPPK_01926	3.13e-114	-	-	-	P	-	-	-	Rhodanese-like domain
CIGNAPPK_01927	1.34e-298	-	2.8.1.7, 4.4.1.16	-	E	ko:K11717	ko00450,ko01100,map00450,map01100	ko00000,ko00001,ko01000	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIGNAPPK_01928	0.0	-	-	-	S	-	-	-	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CIGNAPPK_01930	0.000232	-	2.7.11.1, 2.7.11.17	-	T	ko:K08794,ko:K13412,ko:K17530	ko04626,ko04921,ko04925,ko05145,map04626,map04921,map04925,map05145	ko00000,ko00001,ko01000,ko01001	protein serine/threonine kinase activity
CIGNAPPK_01932	8.14e-75	rplS	-	-	J	ko:K02884	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
CIGNAPPK_01933	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_01934	4.12e-100	-	5.1.99.1	-	E	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	ko00000,ko00001,ko00002,ko01000	Glyoxalase-like domain
CIGNAPPK_01935	0.0	-	2.1.3.15, 6.4.1.3	-	I	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Carboxyl transferase domain
CIGNAPPK_01937	3.41e-55	-	-	-	I	-	-	-	PFAM biotin lipoyl attachment domain-containing protein
CIGNAPPK_01938	0.0	-	4.1.1.3	-	C	ko:K01572	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000,ko02000	Na+-transporting oxaloacetate decarboxylase beta subunit
CIGNAPPK_01939	2.72e-191	-	6.3.4.15	-	H	ko:K03524	ko00780,ko01100,map00780,map01100	ko00000,ko00001,ko01000,ko03000	Biotin/lipoate A/B protein ligase family
CIGNAPPK_01940	0.0	-	-	-	C	-	-	-	Acetyl-CoA hydrolase/transferase C-terminal domain
CIGNAPPK_01942	9.53e-206	-	2.7.7.24	-	M	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CIGNAPPK_01943	7.56e-271	-	4.2.1.46	-	M	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	ko00000,ko00001,ko00002,ko01000	Male sterility protein
CIGNAPPK_01944	1.13e-228	-	2.7.1.11	-	G	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	Phosphofructokinase
CIGNAPPK_01945	2.72e-183	-	-	-	L	ko:K10800	ko03410,map03410	ko00000,ko00001,ko01000,ko03400	uracil-dna glycosylase
CIGNAPPK_01946	0.0	gatB	6.3.5.6, 6.3.5.7	-	J	ko:K02434	ko00970,ko01100,map00970,map01100	ko00000,ko00001,ko01000,ko03029	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIGNAPPK_01947	0.0	poxB	1.2.3.3, 1.2.5.1	-	EH	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	ko00000,ko00001,ko01000	Thiamine pyrophosphate enzyme, central domain
CIGNAPPK_01949	0.0	-	-	-	G	-	-	-	alpha-galactosidase
CIGNAPPK_01951	0.0	-	3.6.3.8	-	P	ko:K01537	-	ko00000,ko01000	Cation transporter/ATPase, N-terminus
CIGNAPPK_01952	2.17e-284	mtrC	-	-	M	ko:K03585	ko01501,ko01503,map01501,map01503	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIGNAPPK_01953	0.0	-	-	-	V	ko:K03296	-	ko00000	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIGNAPPK_01954	0.0	-	-	-	P	ko:K14445	-	ko00000,ko02000	Citrate transporter
CIGNAPPK_01956	6.08e-178	-	2.7.1.49, 2.7.4.7	-	H	ko:K00941	ko00730,ko01100,map00730,map01100	ko00000,ko00001,ko00002,ko01000	Phosphomethylpyrimidine kinase
CIGNAPPK_01958	1.78e-164	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
CIGNAPPK_01961	0.0	-	-	-	L	-	-	-	DNA restriction-modification system
CIGNAPPK_01964	1.12e-114	-	-	-	-	-	-	-	-
CIGNAPPK_01965	1.1e-182	-	-	-	IQ	-	-	-	Enoyl-(Acyl carrier protein) reductase
CIGNAPPK_01967	1.56e-160	-	3.5.1.88	-	J	ko:K01462	-	ko00000,ko01000	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
CIGNAPPK_01968	2.9e-258	tdh	1.1.1.103	-	E	ko:K00060	ko00260,map00260	ko00000,ko00001,ko01000	Alcohol dehydrogenase GroES-like domain
CIGNAPPK_01969	0.0	-	2.4.1.1	GT35	G	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	ko00000,ko00001,ko01000	Carbohydrate phosphorylase
CIGNAPPK_01970	2.13e-182	-	-	-	P	ko:K10716	-	ko00000,ko02000	domain protein
CIGNAPPK_01971	3.13e-83	-	1.20.4.1	-	P	ko:K00537	-	ko00000,ko01000	ArsC family
CIGNAPPK_01972	0.0	-	-	-	J	ko:K07576	-	ko00000	Beta-Casp domain
CIGNAPPK_01973	8.48e-56	tatA	-	-	U	ko:K03116	ko03060,ko03070,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
CIGNAPPK_01974	6.16e-240	-	-	-	S	-	-	-	PFAM Sel1 domain protein repeat-containing protein
CIGNAPPK_01975	2.55e-243	-	5.4.99.22	-	J	ko:K06178	-	ko00000,ko01000,ko03009	RNA pseudouridylate synthase
CIGNAPPK_01976	2.05e-28	-	-	-	-	-	-	-	-
CIGNAPPK_01977	4.67e-173	trmD	2.1.1.228	-	J	ko:K00554	-	ko00000,ko01000,ko03016	tRNA (Guanine-1)-methyltransferase
CIGNAPPK_01978	8.8e-239	prfB	-	-	J	ko:K02836	-	ko00000,ko03012	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CIGNAPPK_01979	1.66e-87	-	-	-	K	ko:K03709	-	ko00000,ko03000	iron dependent repressor
CIGNAPPK_01980	0.0	-	-	-	J	ko:K02945	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
CIGNAPPK_01981	1.72e-134	-	-	-	C	-	-	-	Nitroreductase family
CIGNAPPK_01982	1.23e-110	-	-	-	S	-	-	-	Acetyltransferase (GNAT) family
CIGNAPPK_01987	2.97e-210	-	-	-	M	-	-	-	Peptidase family M23
CIGNAPPK_01988	5.87e-228	-	-	-	G	-	-	-	Xylose isomerase-like TIM barrel
CIGNAPPK_01989	4.13e-183	panB	2.1.2.11	-	H	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
CIGNAPPK_01990	4.21e-121	-	2.7.6.3	-	H	ko:K00950	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
CIGNAPPK_01991	4.14e-175	dapB	1.17.1.8	-	E	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate reductase, N-terminus
CIGNAPPK_01992	2.07e-203	dapA	4.3.3.7	-	EM	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Dihydrodipicolinate synthetase family
CIGNAPPK_01995	1.06e-204	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_01998	0.0	proS	6.1.1.15	-	J	ko:K01881	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Prolyl-tRNA synthetase, C-terminal
CIGNAPPK_01999	4.12e-158	-	-	-	S	-	-	-	Peptidase family M50
CIGNAPPK_02001	2.27e-215	-	-	-	JM	-	-	-	Nucleotidyl transferase
CIGNAPPK_02002	8.25e-273	-	-	-	S	-	-	-	Phosphotransferase enzyme family
CIGNAPPK_02003	1.01e-222	-	5.1.3.2	-	M	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	ko00000,ko00001,ko00002,ko01000	NmrA-like family
CIGNAPPK_02005	0.0	-	-	-	L	ko:K07478	-	ko00000	MgsA AAA+ ATPase C terminal
CIGNAPPK_02006	7.99e-294	-	-	-	-	-	-	-	-
CIGNAPPK_02007	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_02008	1.03e-138	mntP	-	-	P	-	-	-	manganese ion transmembrane transporter activity
CIGNAPPK_02010	1.83e-184	-	-	-	S	-	-	-	Phenazine biosynthesis-like protein
CIGNAPPK_02011	1.34e-175	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase
CIGNAPPK_02012	2.06e-315	-	-	-	K	ko:K03092	ko02020,ko05111,map02020,map05111	ko00000,ko00001,ko03021	Sigma-54 factor, Activator interacting domain (AID)
CIGNAPPK_02013	5.48e-273	ycaD	-	-	EGP	ko:K08219	-	ko00000,ko02000	Major facilitator Superfamily
CIGNAPPK_02014	6.79e-222	-	3.4.11.10, 3.4.11.6	-	DZ	ko:K19701	-	ko00000,ko01000,ko01002	aminopeptidase activity
CIGNAPPK_02015	1.16e-287	-	-	-	G	-	-	-	Xylose isomerase domain protein TIM barrel
CIGNAPPK_02016	0.0	-	-	-	S	-	-	-	inositol 2-dehydrogenase activity
CIGNAPPK_02018	1.88e-274	-	3.6.4.13	-	L	ko:K11927	ko03018,map03018	ko00000,ko00001,ko01000,ko03019	helicase superfamily c-terminal domain
CIGNAPPK_02020	3.6e-145	-	2.7.8.5	-	I	ko:K00995	ko00564,ko01100,map00564,map01100	ko00000,ko00001,ko01000	CDP-alcohol phosphatidyltransferase
CIGNAPPK_02021	0.0	-	6.5.1.2	-	L	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	ko00000,ko00001,ko01000,ko03032,ko03400	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIGNAPPK_02022	0.0	-	3.2.1.51	GH29	G	ko:K01206	ko00511,map00511	ko00000,ko00001,ko01000,ko04147	Alpha-L-fucosidase
CIGNAPPK_02023	9.77e-278	-	4.2.1.51, 5.4.99.5	-	E	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Chorismate mutase type II
CIGNAPPK_02024	3.72e-237	-	5.4.99.23	-	J	ko:K06180	-	ko00000,ko01000,ko03009	Responsible for synthesis of pseudouridine from uracil
CIGNAPPK_02025	1.91e-191	-	-	-	S	-	-	-	NIF3 (NGG1p interacting factor 3)
CIGNAPPK_02026	0.0	-	-	-	S	-	-	-	Domain of unknown function (DUF4340)
CIGNAPPK_02027	0.0	-	-	-	N	-	-	-	ABC-type uncharacterized transport system
CIGNAPPK_02028	2.49e-183	-	-	-	S	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
CIGNAPPK_02029	1.09e-223	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	AAA domain, putative AbiEii toxin, Type IV TA system
CIGNAPPK_02030	0.0	dnaA	-	-	L	ko:K02313	ko02020,ko04112,map02020,map04112	ko00000,ko00001,ko03032,ko03036	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIGNAPPK_02031	2.38e-133	nudF	3.6.1.13	-	L	ko:K01515	ko00230,map00230	ko00000,ko00001,ko01000	nUDIX hydrolase
CIGNAPPK_02033	5e-252	-	2.3.1.1	-	E	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Acetyltransferase (GNAT) family
CIGNAPPK_02034	0.0	secA	-	-	U	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
CIGNAPPK_02035	0.0	-	-	-	L	ko:K03701	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
CIGNAPPK_02037	5.84e-174	-	6.3.5.11, 6.3.5.9	-	V	ko:K02224,ko:K18554	ko00860,ko01100,ko01120,map00860,map01100,map01120	br01600,ko00000,ko00001,ko01000,ko01504	Chloramphenicol phosphotransferase-like protein
CIGNAPPK_02038	6.46e-83	-	-	-	K	ko:K07343	-	ko00000	positive regulation of type IV pilus biogenesis
CIGNAPPK_02039	1.12e-223	-	-	-	CO	-	-	-	Redoxin
CIGNAPPK_02040	1.73e-123	paiA	-	-	K	-	-	-	acetyltransferase
CIGNAPPK_02041	6.52e-216	-	-	-	K	-	-	-	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
CIGNAPPK_02043	0.0	argS	6.1.1.19	-	J	ko:K01887	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	Arginyl tRNA synthetase N terminal dom
CIGNAPPK_02044	0.000939	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_02045	0.0	-	3.4.24.70	-	E	ko:K01414	-	ko00000,ko01000,ko01002	Peptidase family M3
CIGNAPPK_02046	0.0	-	-	-	S	-	-	-	Oxidoreductase family, C-terminal alpha/beta domain
CIGNAPPK_02047	2.51e-06	-	-	-	-	-	-	-	-
CIGNAPPK_02048	0.0	-	-	-	G	-	-	-	Glycosyl hydrolases family 18
CIGNAPPK_02049	0.0	-	-	-	S	ko:K07126,ko:K13582	ko04112,map04112	ko00000,ko00001	beta-lactamase activity
CIGNAPPK_02051	9.75e-278	-	6.2.1.26	-	IQ	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	AMP-binding enzyme
CIGNAPPK_02052	1.04e-69	-	-	-	K	-	-	-	ribonuclease III activity
CIGNAPPK_02053	3.27e-166	-	-	-	-	-	-	-	-
CIGNAPPK_02054	3.49e-139	nuoC	1.6.5.3	-	C	ko:K00332	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_02055	5.36e-138	nuoB	1.6.5.3	-	C	ko:K00331	ko00190,ko01100,map00190,map01100	ko00000,ko00001,ko00002,ko01000	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIGNAPPK_02058	6.1e-46	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_02060	5.18e-06	lepB	3.4.21.89	-	U	ko:K03100	ko02024,ko03060,map02024,map03060	ko00000,ko00001,ko01000,ko01002	Belongs to the peptidase S26 family
CIGNAPPK_02061	0.0	gyrB	5.99.1.3	-	L	ko:K02470	-	ko00000,ko01000,ko03032,ko03400	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIGNAPPK_02062	0.0	-	5.99.1.3	-	L	ko:K02469	-	ko00000,ko01000,ko03032,ko03400	DNA Topoisomerase IV
CIGNAPPK_02063	3.24e-148	-	-	-	C	-	-	-	lactate oxidation
CIGNAPPK_02064	1.45e-296	-	-	-	O	ko:K08303	ko05120,map05120	ko00000,ko00001,ko01000,ko01002	Peptidase family U32
CIGNAPPK_02065	5.28e-20	-	3.5.3.1	-	E	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	ko00000,ko00001,ko00002,ko01000	COG0010 Arginase agmatinase formimionoglutamate hydrolase arginase family
CIGNAPPK_02066	0.0	-	-	-	U	-	-	-	Involved in the tonB-independent uptake of proteins
CIGNAPPK_02067	0.0	-	-	-	C	-	-	-	cytochrome C peroxidase
CIGNAPPK_02068	1.98e-281	-	-	-	J	-	-	-	PFAM Endoribonuclease L-PSP
CIGNAPPK_02070	0.0	-	1.8.1.2	-	P	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Nitrite and sulphite reductase 4Fe-4S domain
CIGNAPPK_02071	1.33e-182	-	-	-	P	ko:K02050	-	ko00000,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_02072	2.4e-188	-	-	-	P	ko:K02049	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_02073	2.06e-258	-	-	-	P	ko:K02051	-	ko00000,ko00002,ko02000	NMT1/THI5 like
CIGNAPPK_02074	0.0	-	2.7.1.25, 2.7.7.4	-	P	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
CIGNAPPK_02075	7.33e-218	-	2.7.7.4	-	EH	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Phosphoadenosine phosphosulfate reductase family
CIGNAPPK_02076	8.78e-172	-	1.8.4.10, 1.8.4.8	-	EH	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Phosphoadenosine phosphosulfate reductase family
CIGNAPPK_02077	1.31e-214	-	2.5.1.47	-	E	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	ko00000,ko00001,ko00002,ko01000	Pyridoxal-phosphate dependent enzyme
CIGNAPPK_02078	3.97e-153	phoU	-	-	P	ko:K02039	-	ko00000	negative regulation of phosphate transmembrane transport
CIGNAPPK_02079	1.62e-183	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CIGNAPPK_02080	0.0	-	-	-	P	ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_02081	0.0	pstC	-	-	P	ko:K02037,ko:K02038	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	Binding-protein-dependent transport system inner membrane component
CIGNAPPK_02082	2.51e-220	-	-	-	P	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	ko00000,ko00001,ko00002,ko02000	PBP superfamily domain
CIGNAPPK_02083	3.69e-185	-	3.6.3.27	-	P	ko:K02036	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
CIGNAPPK_02084	8.65e-140	-	-	-	P	ko:K02039	-	ko00000	PhoU domain
CIGNAPPK_02085	2.15e-234	-	5.1.3.3	-	G	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	ko00000,ko00001,ko00002,ko01000	Converts alpha-aldose to the beta-anomer
CIGNAPPK_02086	7.65e-101	-	-	-	M	ko:K06077	-	ko00000	Glycine zipper 2TM domain
CIGNAPPK_02088	0.0	-	-	-	S	ko:K07263	-	ko00000,ko01000,ko01002	Insulinase (Peptidase family M16)
CIGNAPPK_02089	1.35e-152	-	-	-	H	-	-	-	HD superfamily hydrolase involved in NAD metabolism
CIGNAPPK_02090	1.75e-229	-	-	-	L	-	-	-	Elongator protein 3, MiaB family, Radical SAM
CIGNAPPK_02091	3.03e-231	-	-	-	J	-	-	-	Belongs to the universal ribosomal protein uS2 family
CIGNAPPK_02092	1.7e-101	-	-	-	K	-	-	-	DNA-binding transcription factor activity
CIGNAPPK_02093	9.17e-70	-	-	-	M	-	-	-	Polymer-forming cytoskeletal
CIGNAPPK_02094	2.53e-120	frr	-	-	J	ko:K02838	-	ko00000,ko03012	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
CIGNAPPK_02095	4.62e-165	pyrH	2.7.4.22	-	F	ko:K09903	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko01000	Amino acid kinase family
CIGNAPPK_02096	8.41e-208	-	-	-	M	-	-	-	Mechanosensitive ion channel
CIGNAPPK_02097	3.6e-152	-	1.11.1.15	-	O	ko:K03386	ko04214,map04214	ko00000,ko00001,ko01000,ko04147	C-terminal domain of 1-Cys peroxiredoxin
CIGNAPPK_02098	0.0	-	-	-	S	-	-	-	Sodium:neurotransmitter symporter family
CIGNAPPK_02099	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_02100	2.37e-46	-	-	-	J	-	-	-	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIGNAPPK_02101	3.08e-146	recR	-	-	L	ko:K06187	ko03440,map03440	ko00000,ko00001,ko03400	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIGNAPPK_02103	3.9e-306	-	2.3.1.179	-	I	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
CIGNAPPK_02105	9.82e-110	msrB	1.8.4.11, 1.8.4.12	-	O	ko:K07305,ko:K12267	-	ko00000,ko01000	peptide-methionine (R)-S-oxide reductase activity
CIGNAPPK_02106	7.19e-260	dinB	2.7.7.7	-	L	ko:K02346	-	ko00000,ko01000,ko03400	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIGNAPPK_02107	9.12e-299	nupG	-	-	G	ko:K03289,ko:K03301,ko:K08218,ko:K11537	ko01501,map01501	ko00000,ko00001,ko00002,ko02000	Major facilitator Superfamily
CIGNAPPK_02110	0.0	-	-	-	S	-	-	-	Phage portal protein, lambda family
CIGNAPPK_02111	3.83e-176	-	-	-	OU	ko:K04773	-	ko00000,ko01000,ko01002	Peptidase family S49
CIGNAPPK_02113	5.7e-198	-	-	-	-	-	-	-	-
CIGNAPPK_02123	0.0	-	-	-	D	-	-	-	nuclear chromosome segregation
CIGNAPPK_02129	1.3e-105	-	-	-	L	-	-	-	transposase and inactivated derivatives, IS30 family
CIGNAPPK_02130	0.0	-	-	-	S	-	-	-	Phage terminase large subunit (GpA)
CIGNAPPK_02135	4.69e-135	-	-	-	S	-	-	-	Glycosyl hydrolase 108
CIGNAPPK_02136	9.25e-103	-	-	-	K	ko:K07726	-	ko00000,ko03000	sequence-specific DNA binding
CIGNAPPK_02137	3.93e-45	-	-	-	N	-	-	-	mRNA binding
CIGNAPPK_02142	3.12e-190	-	-	-	K	-	-	-	BRO family, N-terminal domain
CIGNAPPK_02152	5.33e-217	-	-	-	M	-	-	-	PFAM YD repeat-containing protein
CIGNAPPK_02153	6.59e-78	-	-	-	M	-	-	-	self proteolysis
CIGNAPPK_02157	0.0	kdpA	3.6.3.12	-	P	ko:K01546	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CIGNAPPK_02158	0.0	kdpB	3.6.3.12	-	P	ko:K01547	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CIGNAPPK_02159	1.26e-132	kdpC	3.6.3.12	-	P	ko:K01548	ko02020,map02020	ko00000,ko00001,ko01000	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CIGNAPPK_02160	3.88e-263	-	2.7.13.3	-	T	ko:K07646	ko02020,map02020	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	Osmosensitive K+ channel His kinase sensor domain
CIGNAPPK_02161	1.97e-230	-	2.7.11.1	-	T	ko:K08884,ko:K12132,ko:K20333	ko02024,map02024	ko00000,ko00001,ko01000,ko01001	PFAM Formylglycine-generating sulfatase enzyme
CIGNAPPK_02163	4.85e-195	-	-	-	S	-	-	-	Metallo-beta-lactamase superfamily
CIGNAPPK_02164	3.34e-139	-	-	-	K	ko:K03088	-	ko00000,ko03021	DNA-templated transcription, initiation
CIGNAPPK_02165	0.0	-	-	-	KLT	-	-	-	Protein tyrosine kinase
CIGNAPPK_02166	2.81e-280	-	-	-	C	-	-	-	Aldo/keto reductase family
CIGNAPPK_02167	6.71e-90	-	-	-	K	-	-	-	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CIGNAPPK_02168	2.44e-260	-	4.1.2.48	-	E	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	Beta-eliminating lyase
CIGNAPPK_02169	2.53e-293	-	-	-	-	-	-	-	-
CIGNAPPK_02170	0.0	-	-	-	S	-	-	-	von Willebrand factor type A domain
CIGNAPPK_02171	0.0	-	-	-	S	-	-	-	Aerotolerance regulator N-terminal
CIGNAPPK_02172	1.58e-205	-	-	-	S	-	-	-	Protein of unknown function DUF58
CIGNAPPK_02173	0.0	-	-	-	S	-	-	-	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIGNAPPK_02174	1.78e-241	-	-	-	V	-	-	-	ATPases associated with a variety of cellular activities
CIGNAPPK_02175	0.0	-	-	-	-	-	-	-	-
CIGNAPPK_02176	2.12e-237	-	-	-	S	ko:K03924	-	ko00000,ko01000	ATPase family associated with various cellular activities (AAA)
CIGNAPPK_02177	4.24e-296	-	-	-	S	ko:K07148	-	ko00000	Protein of unknown function (DUF418)
CIGNAPPK_02179	4.01e-240	-	-	-	E	-	-	-	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIGNAPPK_02181	5.75e-202	-	-	-	O	-	-	-	stress-induced mitochondrial fusion
CIGNAPPK_02182	1.96e-208	-	-	-	S	ko:K07071	-	ko00000	Domain of unknown function (DUF1731)
CIGNAPPK_02183	5.98e-121	-	-	-	M	ko:K03098	-	ko00000,ko04147	Lipocalin-like domain
CIGNAPPK_02184	1.35e-236	-	1.1.1.86	-	E	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CIGNAPPK_02185	9.78e-188	-	3.6.3.34	-	P	ko:K02013	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_02186	9.64e-153	-	-	-	K	-	-	-	Transcriptional regulator
CIGNAPPK_02188	0.0	-	-	-	P	-	-	-	Sulfatase
CIGNAPPK_02190	1.04e-78	divIC	-	-	D	ko:K05589,ko:K13052	-	ko00000,ko03036	cell cycle
CIGNAPPK_02191	4.6e-305	-	4.2.1.11	-	G	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
CIGNAPPK_02192	2.45e-48	-	-	-	E	-	-	-	Aminotransferase class I and II
CIGNAPPK_02193	0.0	-	-	-	E	-	-	-	Aminotransferase class I and II
CIGNAPPK_02194	1.51e-220	-	2.7.1.180	-	H	ko:K03734	-	ko00000,ko01000	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
CIGNAPPK_02195	0.0	-	3.2.1.22	-	G	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	ko00000,ko00001,ko01000	Alpha galactosidase A
CIGNAPPK_02196	1.04e-49	-	-	-	-	-	-	-	-
CIGNAPPK_02197	1.45e-55	rpmB	-	-	J	ko:K02902	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal L28 family
CIGNAPPK_02198	1.5e-232	-	-	-	C	-	-	-	Zinc-binding dehydrogenase
CIGNAPPK_02199	2.13e-96	-	-	-	L	ko:K07447	-	ko00000,ko01000	Likely ribonuclease with RNase H fold.
CIGNAPPK_02200	2.41e-259	-	2.7.7.13	-	M	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Nucleotidyl transferase
CIGNAPPK_02201	1.06e-173	-	2.5.1.31	-	I	ko:K00806	ko00900,ko01110,map00900,map01110	ko00000,ko00001,ko01000,ko01006	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIGNAPPK_02202	0.0	-	-	-	L	ko:K02622	-	ko00000,ko01000,ko02048,ko03032,ko03036	TopoisomeraseII
CIGNAPPK_02203	1.42e-209	ispE	2.7.1.148	-	I	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GHMP kinases N terminal domain
CIGNAPPK_02205	0.0	-	3.6.4.12	-	L	ko:K03722	-	ko00000,ko01000,ko03400	HELICc2
CIGNAPPK_02206	6.85e-179	cbiO	-	-	P	ko:K02006,ko:K02008,ko:K16784,ko:K16786	ko02010,map02010	ko00000,ko00001,ko00002,ko01000,ko02000	ATPase activity
CIGNAPPK_02207	2.42e-195	cbiQ	-	-	P	ko:K02007,ko:K02008	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	transmembrane transporter activity
CIGNAPPK_02208	1.77e-238	cbiM	-	-	P	ko:K02007,ko:K02009,ko:K16915	ko02010,map02010	ko00000,ko00001,ko00002,ko02000	cobalt ion transport
CIGNAPPK_02210	1.06e-18	-	-	-	S	-	-	-	Lipocalin-like
CIGNAPPK_02211	3.2e-209	argB	2.7.2.8	-	E	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Amino acid kinase family
CIGNAPPK_02212	1.05e-226	-	-	-	P	ko:K03284	-	ko00000,ko02000	CorA-like Mg2+ transporter protein
CIGNAPPK_02213	1.06e-94	rplI	-	-	J	ko:K02939	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L9, N-terminal domain
CIGNAPPK_02214	0.0	-	2.1.2.3, 3.5.4.10	-	F	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	ko00000,ko00001,ko00002,ko01000,ko04147	AICARFT/IMPCHase bienzyme
CIGNAPPK_02215	5.64e-173	pdxJ	2.6.99.2	-	H	ko:K03474	ko00750,ko01100,map00750,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CIGNAPPK_02216	7.44e-84	acpS	2.7.8.7	-	I	ko:K00997	ko00770,map00770	ko00000,ko00001,ko01000	4'-phosphopantetheinyl transferase superfamily
CIGNAPPK_02218	0.0	pckG	4.1.1.32	-	C	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	ko00000,ko00001,ko00002,ko01000	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
CIGNAPPK_02219	4.02e-166	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
CIGNAPPK_02220	0.0	-	3.6.4.12	-	L	ko:K03655	ko03440,map03440	ko00000,ko00001,ko01000,ko03400	RecG wedge domain
CIGNAPPK_02222	0.0	-	-	-	C	ko:K00184	-	ko00000	4Fe-4S dicluster domain
CIGNAPPK_02223	6.18e-180	-	-	-	C	-	-	-	Cytochrome c7 and related cytochrome c
CIGNAPPK_02224	2.09e-302	-	-	-	S	-	-	-	Oxidoreductase family, NAD-binding Rossmann fold
CIGNAPPK_02226	4.46e-255	aroB	4.2.3.4	-	E	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	ko00000,ko00001,ko00002,ko01000	Iron-containing alcohol dehydrogenase
CIGNAPPK_02229	9.55e-242	asd	1.2.1.11	-	E	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	ko00000,ko00001,ko00002,ko01000	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIGNAPPK_02230	4.54e-209	-	2.5.1.1, 2.5.1.10, 2.5.1.29	-	H	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000,ko01006	Polyprenyl synthetase
CIGNAPPK_02231	1.77e-201	-	2.4.2.19	-	H	ko:K00767	ko00760,ko01100,map00760,map01100	ko00000,ko00001,ko00002,ko01000	Quinolinate phosphoribosyl transferase, N-terminal domain
CIGNAPPK_02232	3.45e-157	-	1.4.3.5	-	H	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	ko00000,ko00001,ko00002,ko01000	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
CIGNAPPK_02233	2.77e-217	-	5.1.3.15	-	G	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	ko00000,ko00001,ko01000	Aldose 1-epimerase
CIGNAPPK_02234	0.0	-	-	-	G	-	-	-	Trehalase
CIGNAPPK_02235	0.0	-	-	-	E	-	-	-	GDSL-like Lipase/Acylhydrolase family
CIGNAPPK_02236	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
CIGNAPPK_02237	1.1e-34	-	-	-	J	ko:K02914	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein L34
CIGNAPPK_02238	4.9e-76	-	3.1.26.5	-	J	ko:K03536	-	ko00000,ko01000,ko03016	Ribonuclease P
CIGNAPPK_02239	1.32e-60	-	-	-	S	ko:K08998	-	ko00000	Haemolytic
CIGNAPPK_02240	0.0	yidC	-	-	U	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	ko00000,ko00001,ko00002,ko02044,ko03029	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
CIGNAPPK_02241	0.0	-	1.4.1.13, 1.4.1.14	-	E	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	ko00000,ko00001,ko01000	GXGXG motif
CIGNAPPK_02242	0.0	glnA	6.3.1.2	-	S	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	ko00000,ko00001,ko01000,ko04147	glutamine synthetase
CIGNAPPK_02243	0.0	-	6.3.5.5	-	EF	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CIGNAPPK_02244	1.88e-273	carA	6.3.5.5	-	F	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	ko00000,ko00001,ko00002,ko01000	Carbamoyl-phosphate synthase small chain, CPSase domain
CIGNAPPK_02245	6.96e-265	-	4.2.1.47	-	M	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CIGNAPPK_02246	1.31e-268	fcl	1.1.1.271	-	GM	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	ko00000,ko00001,ko01000	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
CIGNAPPK_02247	5.05e-297	-	-	-	C	-	-	-	Na+/H+ antiporter family
CIGNAPPK_02248	5.85e-276	-	-	-	-	-	-	-	-
CIGNAPPK_02249	1.39e-228	-	5.3.1.8	-	G	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Phosphomannose isomerase type I
CIGNAPPK_02250	1.29e-181	-	3.5.1.28	-	M	ko:K01447	-	ko00000,ko01000	PFAM N-acetylmuramoyl-L-alanine amidase family 2
CIGNAPPK_02251	1.93e-117	ispF	4.6.1.12	-	I	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
CIGNAPPK_02252	2.32e-185	-	3.1.3.25	-	G	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	ko00000,ko00001,ko00002,ko01000	Inositol monophosphatase family
CIGNAPPK_02253	0.0	-	-	-	M	-	-	-	PFAM glycosyl transferase family 51
CIGNAPPK_02254	0.0	-	-	-	S	-	-	-	Tetratricopeptide repeat
CIGNAPPK_02255	1.08e-97	-	-	-	U	ko:K03559	-	ko00000,ko02000	Biopolymer transport protein ExbD/TolR
CIGNAPPK_02256	6.34e-183	-	-	-	U	ko:K03561	-	ko00000,ko02000	MotA/TolQ/ExbB proton channel family
CIGNAPPK_02257	0.0	-	-	-	L	ko:K03703	ko03420,map03420	ko00000,ko00001,ko03400	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
CIGNAPPK_02258	1.27e-99	-	2.1.1.177	-	J	ko:K00783	-	ko00000,ko01000,ko03009	Predicted SPOUT methyltransferase
CIGNAPPK_02259	1.67e-86	rpsI	-	-	J	ko:K02996	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S9/S16
CIGNAPPK_02260	2.79e-97	rplM	-	-	J	ko:K02871	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIGNAPPK_02261	6.12e-40	infA	-	-	J	ko:K02518	-	ko00000,ko03012	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIGNAPPK_02262	0.0	nnrD	4.2.1.136, 5.1.99.6	-	G	ko:K17758,ko:K17759	-	ko00000,ko01000	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CIGNAPPK_02263	8.01e-173	-	-	-	L	ko:K03630	-	ko00000	RadC-like JAB domain
CIGNAPPK_02265	4.03e-174	-	-	-	D	-	-	-	Phage-related minor tail protein
CIGNAPPK_02267	0.0	dnaX	2.7.7.7	-	L	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIGNAPPK_02268	8.25e-63	-	-	-	L	ko:K09747	-	ko00000	YbaB/EbfC DNA-binding family
CIGNAPPK_02269	5.41e-253	-	-	-	N	ko:K18353	ko01502,ko02020,map01502,map02020	ko00000,ko00001,ko00002,ko01504	Endonuclease Exonuclease Phosphatase
CIGNAPPK_02270	0.0	-	3.6.1.1	-	C	ko:K15986	ko00190,map00190	ko00000,ko00001,ko01000	DHHA2
CIGNAPPK_02272	5.46e-189	-	4.1.1.23	-	F	ko:K01591	ko00240,ko01100,map00240,map01100	ko00000,ko00001,ko00002,ko01000	Orotidine 5'-phosphate decarboxylase / HUMPS family
CIGNAPPK_02273	0.0	-	-	-	S	-	-	-	OPT oligopeptide transporter protein
CIGNAPPK_02274	0.000651	-	-	-	-	-	-	-	-
CIGNAPPK_02275	0.0	-	-	-	G	-	-	-	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
CIGNAPPK_02276	1.29e-187	-	1.3.5.1, 1.3.5.4	-	C	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002,ko01000	2Fe-2S iron-sulfur cluster binding domain
CIGNAPPK_02277	0.0	-	1.3.5.1, 1.3.5.4	-	C	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	ko00000,ko00001,ko00002,ko01000	Fumarate reductase flavoprotein C-term
CIGNAPPK_02278	4.83e-163	-	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	ko00000,ko00001,ko00002	-
CIGNAPPK_02279	8.94e-56	-	-	-	-	-	-	-	-
CIGNAPPK_02280	2.88e-194	-	-	-	S	ko:K07051	-	ko00000	TatD related DNase
CIGNAPPK_02281	2.14e-48	XK27_09985	-	-	S	-	-	-	Protein of unknown function (DUF1232)
CIGNAPPK_02283	1.15e-05	-	-	-	-	-	-	-	-
CIGNAPPK_02284	2.14e-19	-	-	-	S	-	-	-	Acetyltransferase (GNAT) domain
CIGNAPPK_02285	7.5e-306	-	-	-	C	-	-	-	Sulfatase-modifying factor enzyme 1
CIGNAPPK_02286	2.57e-170	-	1.1.1.100	-	IQ	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	ko00000,ko00001,ko00002,ko01000,ko01004	KR domain
CIGNAPPK_02288	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
CIGNAPPK_02289	2.17e-08	-	-	-	M	-	-	-	major outer membrane lipoprotein
CIGNAPPK_02291	4.21e-137	-	-	-	J	ko:K05808	-	ko00000,ko03009	Sigma 54 modulation/S30EA ribosomal protein C terminus
CIGNAPPK_02293	8.88e-149	corC_1	-	-	P	ko:K03699	-	ko00000,ko02042	Psort location CytoplasmicMembrane, score
CIGNAPPK_02294	4.04e-160	-	-	-	IQ	-	-	-	Short chain dehydrogenase
CIGNAPPK_02295	3.93e-308	-	-	-	C	-	-	-	Carboxymuconolactone decarboxylase family
CIGNAPPK_02296	2.9e-275	-	-	-	S	ko:K06889	-	ko00000	X-Pro dipeptidyl-peptidase (S15 family)
CIGNAPPK_02297	8.36e-186	-	-	-	S	-	-	-	Alpha/beta hydrolase family
CIGNAPPK_02298	4.25e-178	-	-	-	C	-	-	-	aldo keto reductase
CIGNAPPK_02299	4.26e-219	-	-	-	K	-	-	-	Transcriptional regulator
CIGNAPPK_02300	0.0	-	-	-	G	-	-	-	Belongs to the glycosyl hydrolase 31 family
CIGNAPPK_02301	3.9e-303	-	-	-	C	-	-	-	4 iron, 4 sulfur cluster binding
CIGNAPPK_02302	1.88e-111	-	-	-	KT	ko:K07705	ko02020,map02020	ko00000,ko00001,ko00002,ko02022	phosphorelay signal transduction system
CIGNAPPK_02303	2.59e-174	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
CIGNAPPK_02304	1.61e-183	-	-	-	-	-	-	-	-
CIGNAPPK_02305	4.19e-133	-	-	-	S	-	-	-	Protein of unknown function (DUF2589)
CIGNAPPK_02306	1.2e-49	-	-	-	-	-	-	-	-
CIGNAPPK_02308	4.9e-74	-	-	-	S	ko:K09954	-	ko00000	Putative quorum-sensing-regulated virulence factor
CIGNAPPK_02309	5.94e-178	-	4.2.99.20	-	I	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	ko00000,ko00001,ko00002,ko01000	Alpha/beta hydrolase family
CIGNAPPK_02310	1.69e-129	-	-	-	U	ko:K05595	-	ko00000,ko02000	MarC family integral membrane protein
CIGNAPPK_02315	2.41e-232	-	-	-	E	-	-	-	PFAM lipolytic protein G-D-S-L family
CIGNAPPK_02318	7.48e-188	-	-	-	O	ko:K04083	-	ko00000,ko03110	Hsp33 protein
CIGNAPPK_02319	3.62e-121	-	5.2.1.8	-	O	ko:K03768	-	ko00000,ko01000,ko03110	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIGNAPPK_02320	0.0	-	-	-	S	ko:K06158	-	ko00000,ko03012	ABC transporter
CIGNAPPK_02321	9.28e-139	-	-	-	-	-	-	-	-
CIGNAPPK_02322	5.74e-211	ybfH	-	-	EG	-	-	-	spore germination
CIGNAPPK_02323	1.6e-75	-	-	-	G	-	-	-	Cupin 2, conserved barrel domain protein
CIGNAPPK_02324	0.0	cysS	6.1.1.16	-	J	ko:K01883	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	tRNA synthetases class I (C) catalytic domain
CIGNAPPK_02325	0.0	-	3.2.1.52	GH20	G	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	ko00000,ko00001,ko00002,ko01000,ko03110	Glycoside hydrolase, family 20, catalytic core
CIGNAPPK_02326	0.0	-	-	-	P	-	-	-	Domain of unknown function (DUF4976)
CIGNAPPK_02327	9.83e-235	-	-	-	CO	-	-	-	Thioredoxin-like
CIGNAPPK_02329	0.0	lepA	-	-	M	ko:K03596	ko05134,map05134	ko00000,ko00001	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
CIGNAPPK_02330	6.21e-39	-	-	-	-	-	-	-	-
CIGNAPPK_02337	1.05e-188	-	5.2.1.8	-	O	ko:K03773	-	ko00000,ko01000,ko03110	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
CIGNAPPK_02338	5.35e-139	-	2.1.2.2	-	F	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIGNAPPK_02339	8.59e-273	-	-	-	E	ko:K19689	-	ko00000,ko01000,ko01002	Thermophilic metalloprotease (M29)
CIGNAPPK_02340	5.34e-210	-	-	-	S	ko:K07098	-	ko00000	Calcineurin-like phosphoesterase superfamily domain
CIGNAPPK_02341	0.0	-	-	-	P	ko:K03455	-	ko00000	TrkA-N domain
CIGNAPPK_02342	1.2e-167	-	-	-	L	ko:K03424	-	ko00000,ko01000	TatD related DNase
CIGNAPPK_02348	1.97e-135	panZ	-	-	K	-	-	-	-acetyltransferase
CIGNAPPK_02349	8.67e-228	-	-	-	E	ko:K00612	-	ko00000,ko01000	lipolytic protein G-D-S-L family
CIGNAPPK_02350	7.15e-221	-	1.8.1.9	-	O	ko:K00384	ko00450,map00450	ko00000,ko00001,ko01000	Pyridine nucleotide-disulphide oxidoreductase
CIGNAPPK_02351	0.0	-	4.3.1.17	-	E	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	ko00000,ko00001,ko01000	Serine dehydratase alpha chain
CIGNAPPK_02352	5.5e-176	-	-	-	-	-	-	-	-
CIGNAPPK_02353	0.0	gcvP	1.4.4.2	-	E	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIGNAPPK_02354	6.67e-86	gcvH	-	-	E	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
CIGNAPPK_02355	2.85e-267	gcvT	2.1.2.10	-	E	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	ko00000,ko00001,ko00002,ko01000	Aminomethyltransferase folate-binding domain
CIGNAPPK_02356	5.5e-262	ychF	-	-	J	ko:K06942	-	ko00000,ko03009	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
CIGNAPPK_02357	6.04e-219	-	3.4.16.4	-	M	ko:K07258	ko00550,ko01100,map00550,map01100	ko00000,ko00001,ko01000,ko01002,ko01011	D-alanyl-D-alanine carboxypeptidase
CIGNAPPK_02358	3.24e-271	-	-	-	LU	ko:K04096	-	ko00000	DNA recombination-mediator protein A
CIGNAPPK_02359	3.63e-270	-	-	-	M	-	-	-	Glycosyl transferase 4-like
CIGNAPPK_02360	1.18e-224	-	-	-	M	ko:K07276	-	ko00000	Mitochondrial fission ELM1
CIGNAPPK_02361	1.12e-269	-	1.17.99.6	-	C	ko:K18979	-	ko00000,ko01000,ko03016	Domain of unknown function (DUF1730)
CIGNAPPK_02362	1.11e-79	rpsM	-	-	J	ko:K02952	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIGNAPPK_02363	2.11e-121	rpsK	-	-	J	ko:K02948	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CIGNAPPK_02364	4.36e-142	-	-	-	J	ko:K02986	ko03010,map03010	br01610,ko00000,ko00001,ko00002,ko03011	Ribosomal protein S4/S9 N-terminal domain
CIGNAPPK_02365	3.44e-192	-	-	-	E	-	-	-	haloacid dehalogenase-like hydrolase
CIGNAPPK_02369	1.07e-124	-	-	-	K	-	-	-	Acetyltransferase (GNAT) domain
CIGNAPPK_02370	0.0	-	2.7.1.40	-	G	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	Pyruvate kinase, barrel domain
CIGNAPPK_02371	2.41e-288	-	3.5.1.42	-	S	ko:K03742	ko00760,map00760	ko00000,ko00001,ko01000	Competence-damaged protein
CIGNAPPK_02372	6.87e-153	-	-	-	O	-	-	-	methyltransferase activity
CIGNAPPK_02373	7.92e-183	-	-	-	U	ko:K20276	ko02024,map02024	ko00000,ko00001	domain, Protein
CIGNAPPK_02374	0.0	-	-	-	CO	-	-	-	Thioredoxin-like
CIGNAPPK_02390	2.58e-69	-	-	-	MP	-	-	-	regulation of cell-substrate adhesion
CIGNAPPK_02393	2.03e-38	-	-	-	L	-	-	-	Mu-like prophage protein gp29
CIGNAPPK_02394	1.01e-18	-	3.6.4.12	-	L	ko:K02314	ko03030,ko04112,map03030,map04112	ko00000,ko00001,ko01000,ko03032	DnaB-like helicase C terminal domain
CIGNAPPK_02395	1.84e-300	-	-	-	L	ko:K04763	-	ko00000,ko03036	Belongs to the 'phage' integrase family
CIGNAPPK_02397	9.22e-248	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
CIGNAPPK_02398	4.18e-243	-	-	-	V	ko:K01992	-	ko00000,ko00002,ko02000	ABC-2 family transporter protein
CIGNAPPK_02399	0.0	-	-	-	V	ko:K01990	-	ko00000,ko00002,ko02000	ATPases associated with a variety of cellular activities
CIGNAPPK_02400	1.37e-227	-	-	-	M	ko:K01993	-	ko00000	HlyD family secretion protein
CIGNAPPK_02401	0.0	alaS	6.1.1.7	-	J	ko:K01872	ko00970,map00970	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIGNAPPK_02402	3.85e-194	-	2.7.8.8	-	I	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	ko00000,ko00001,ko00002,ko01000	CDP-alcohol phosphatidyltransferase
CIGNAPPK_02403	1.64e-119	-	-	-	-	-	-	-	-
CIGNAPPK_02404	6.16e-198	-	2.5.1.15	-	H	ko:K00796	ko00790,ko01100,map00790,map01100	ko00000,ko00001,ko00002,ko01000	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIGNAPPK_02405	0.0	-	-	-	M	-	-	-	Bacterial membrane protein, YfhO
CIGNAPPK_02406	0.0	ispG	1.17.7.1, 1.17.7.3	-	I	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	ko00000,ko00001,ko00002,ko01000	GcpE protein
CIGNAPPK_02407	1.14e-148	-	-	-	IQ	-	-	-	RmlD substrate binding domain