Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 29 | 36.40 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| IOEGKKHE_1 | 1112346 | 1113215 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| IOEGKKHE_1 | 1111753 | 1112346 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| IOEGKKHE_1 | 1336656 | 1337915 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681445 |
| IOEGKKHE_1 | 1111753 | 1112346 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| IOEGKKHE_1 | 1111753 | 1112346 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| IOEGKKHE_1 | 1335683 | 1336659 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.59 | 99.90 | WP_011681444 |
| IOEGKKHE_1 | 864151 | 865809 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| IOEGKKHE_1 | 43869 | 44708 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| IOEGKKHE_1 | 1334697 | 1335665 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 99.28 | 100.00 | WP_011681443 |
| IOEGKKHE_1 | 1148539 | 1149300 | srtA | 0.0 | Sortase A | Exoenzyme | 99.21 | 100.00 | - |
| IOEGKKHE_1 | 974507 | 975238 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 99.18 | 100.00 | WP_011226048 |
| IOEGKKHE_1 | 974507 | 975238 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011227248 |
| IOEGKKHE_1 | 974507 | 975238 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011681176 |
| IOEGKKHE_1 | 1333980 | 1334695 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.32 | 99.86 | WP_011681442 |
| IOEGKKHE_1 | 1332864 | 1333634 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 97.92 | 99.23 | WP_011681440 |
| IOEGKKHE_1 | 964538 | 965953 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| IOEGKKHE_1 | 975239 | 976699 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.67 | 100.00 | WP_011681177 |
| IOEGKKHE_1 | 1054094 | 1054892 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 97.62 | 100.88 | - |
| IOEGKKHE_1 | 1338034 | 1338885 | rfbD | 0.0 | Capsule | Immune modulation | 97.30 | 100.00 | WP_014621820 |
| IOEGKKHE_1 | 973806 | 974498 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 97.11 | 100.00 | WP_011226047 |
| IOEGKKHE_1 | 973806 | 974498 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 96.97 | 100.00 | WP_011227247 |
| IOEGKKHE_1 | 975239 | 976699 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.65 | 100.21 | WP_011226049 |
| IOEGKKHE_1 | 975239 | 976699 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.96 | 100.21 | WP_041827043 |
| IOEGKKHE_1 | 971616 | 972981 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.46 | 99.85 | WP_011681173 |
| IOEGKKHE_1 | 971614 | 972981 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.08 | 100.00 | WP_011226045 |
| IOEGKKHE_1 | 973038 | 973796 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 93.41 | 100.94 | WP_011681174 |
| IOEGKKHE_1 | 973038 | 973796 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 93.02 | 100.94 | WP_011226046 |
| IOEGKKHE_1 | 973043 | 973796 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 92.71 | 99.07 | WP_011227246 |
| IOEGKKHE_1 | 973806 | 974498 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 90.06 | 99.86 | WP_011681175 |
| IOEGKKHE_1 | 610398 | 611701 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| IOEGKKHE_1 | 1624601 | 1625611 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| IOEGKKHE_1 | 1110278 | 1111324 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| IOEGKKHE_1 | 148663 | 149946 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.58 | 99.77 | WP_000107753 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| IOEGKKHE_1 | 1151987 | 1152970 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| IOEGKKHE_1 | 714549 | 715622 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| IOEGKKHE_1 | 1501630 | 1503933 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| IOEGKKHE_1 | 526796 | 527764 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| IOEGKKHE_1 | 1221123 | 1222604 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| IOEGKKHE_1 | 746463 | 748709 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| IOEGKKHE_1 | 70521 | 71513 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| IOEGKKHE_1 | 27386 | 28357 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| IOEGKKHE_1 | 1387818 | 1386667 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| IOEGKKHE_1 | 1351923 | 1349935 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| IOEGKKHE_1 | 1135789 | 1134059 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 87.87 | 100.00 | AAK34199 |
| IOEGKKHE_1 | 1821057 | 1819579 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| IOEGKKHE_1 | 610398 | 611699 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| IOEGKKHE_1 | 1805868 | 1803976 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| IOEGKKHE_1 | 751634 | 749925 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| IOEGKKHE_1 | 1666287 | 1667297 | pdh | 0.0 | pyruvate dehydrogenase | 82.79 | 99.70 | ABP91006 |
| IOEGKKHE_1 | 893708 | 892347 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| IOEGKKHE_1 | 1718309 | 1716417 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| IOEGKKHE_1 | 595963 | 596853 | bglB | 5.19e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| IOEGKKHE_1 | 809209 | 808274 | SP_0676 | 7.30e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| IOEGKKHE_1 | 748901 | 749758 | metF | 1.51e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| IOEGKKHE_1 | 1013519 | 1012815 | covR | 4.33e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| IOEGKKHE_1 | 1202148 | 1201477 | rr01 | 2.97e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| IOEGKKHE_1 | 1013519 | 1012815 | walR | 1.82e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| IOEGKKHE_1 | 303091 | 303777 | CovR | 1.01e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| IOEGKKHE_1 | 755588 | 756256 | CiaR | 2.00e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| IOEGKKHE_1 | 755588 | 756259 | ciaR | 1.97e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| IOEGKKHE_1 | 71810 | 72184 | SpxA2 | 1.14e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| IOEGKKHE_1 | 905072 | 905473 | SpxA1 | 3.72e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| IOEGKKHE_1 | 150104 | 150604 | RopE (M5005_Spy_1611) | 4.87e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| IOEGKKHE_1 | 1501630 | 1503927 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| IOEGKKHE_1 | 1703835 | 1702816 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| IOEGKKHE_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)