Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 22 | 28 | 35.61 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| IADDBMHP_1 | 1044227 | 1044967 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 94.87 | 100.00 | WP_011681174 |
| IADDBMHP_1 | 1691296 | 1692147 | rfbD | 0.0 | Capsule | Immune modulation | 94.37 | 100.00 | WP_014621820 |
| IADDBMHP_1 | 1041324 | 1042784 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 94.25 | 100.14 | WP_011226049 |
| IADDBMHP_1 | 1045024 | 1046391 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.15 | 100.00 | WP_011226045 |
| IADDBMHP_1 | 1045024 | 1046389 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.14 | 99.85 | WP_011681173 |
| IADDBMHP_1 | 1041324 | 1042784 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 94.11 | 100.00 | WP_011681177 |
| IADDBMHP_1 | 1044227 | 1044967 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 94.06 | 100.00 | WP_011226046 |
| IADDBMHP_1 | 1044227 | 1044962 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 93.61 | 98.13 | WP_011227246 |
| IADDBMHP_1 | 1041324 | 1042784 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 93.36 | 100.14 | WP_041827043 |
| IADDBMHP_1 | 1688299 | 1689108 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 92.97 | 99.88 | WP_002948020 |
| IADDBMHP_1 | 1689092 | 1690048 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 92.69 | 99.90 | WP_011226328 |
| IADDBMHP_1 | 1684274 | 1686030 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 92.66 | 98.43 | WP_011226325 |
| IADDBMHP_1 | 827183 | 827776 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 92.42 | 100.00 | WP_011226149 |
| IADDBMHP_1 | 1690045 | 1691193 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 92.35 | 99.91 | WP_041828290 |
| IADDBMHP_1 | 827183 | 827776 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 92.26 | 100.00 | WP_011226149 |
| IADDBMHP_1 | 827183 | 827776 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 92.26 | 100.00 | WP_011226149 |
| IADDBMHP_1 | 1042785 | 1043516 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 92.21 | 100.00 | WP_011226048 |
| IADDBMHP_1 | 1687094 | 1688299 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 92.04 | 100.00 | WP_011226326 |
| IADDBMHP_1 | 1042785 | 1043516 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 91.80 | 100.00 | WP_011681176 |
| IADDBMHP_1 | 826314 | 827183 | rfbA | 0.0 | Capsule | Immune modulation | 91.49 | 100.00 | WP_011681286 |
| IADDBMHP_1 | 1686027 | 1687073 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 91.38 | 99.43 | WP_002948022 |
| IADDBMHP_1 | 1042785 | 1043516 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 91.26 | 100.00 | WP_011227248 |
| IADDBMHP_1 | 43035 | 43874 | cbpD | 0.0 | Autolysin | Exoenzyme | 91.07 | 100.00 | WP_011226733 |
| IADDBMHP_1 | 1150616 | 1152270 | fbp54 | 0.0 | FBPs | Adherence | 90.94 | 99.70 | WP_011227179 |
| IADDBMHP_1 | 1043525 | 1044217 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 88.63 | 99.71 | WP_011227247 |
| IADDBMHP_1 | 1043525 | 1044217 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 88.63 | 99.71 | WP_011226047 |
| IADDBMHP_1 | 649122 | 650425 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| IADDBMHP_1 | 1043525 | 1044217 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 87.48 | 99.71 | WP_011681175 |
| IADDBMHP_1 | 1993105 | 1994115 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.36 | 99.80 | WP_002986042 |
| IADDBMHP_1 | 827979 | 829025 | rfbB | 0.0 | Capsule | Immune modulation | 84.54 | 99.90 | WP_002263087 |
| IADDBMHP_1 | 1299242 | 1300003 | srtA | 0.0 | Sortase A | Exoenzyme | 84.29 | 99.74 | - |
| IADDBMHP_1 | 137697 | 138980 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.68 | 99.61 | WP_000107753 |
| IADDBMHP_1 | 1054578 | 1055161 | SPD_RS01775 | 2.80e-148 | Capsule | Immune modulation | 83.25 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| IADDBMHP_1 | 1302692 | 1303675 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 96.95 | 100.00 | AAK75326 |
| IADDBMHP_1 | 1291105 | 1290032 | MntE | 0.0 | manganese homeostasis | 96.09 | 99.72 | ABF32167 |
| IADDBMHP_1 | 1869745 | 1872051 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 94.41 | 99.22 | AAK74619 |
| IADDBMHP_1 | 558646 | 559614 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| IADDBMHP_1 | 1450325 | 1451806 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 93.12 | 100.00 | ABJ54480 |
| IADDBMHP_1 | 1272049 | 1269803 | metE | 0.0 | methionine biosynthesis enzymes | 92.92 | 100.00 | AAK74738 |
| IADDBMHP_1 | 24540 | 25511 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 91.36 | 100.00 | ABF36968 |
| IADDBMHP_1 | 800933 | 802663 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 90.12 | 100.00 | AAK34199 |
| IADDBMHP_1 | 1732629 | 1731478 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.58 | 99.74 | AAL00050 |
| IADDBMHP_1 | 1704151 | 1702163 | uvrB | 0.0 | excinuclease ABC, B subunit | 89.44 | 100.00 | AE014259_2 |
| IADDBMHP_1 | 2199603 | 2198125 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.83 | 100.00 | ADE32434 |
| IADDBMHP_1 | 649122 | 650423 | Eno | 0.0 | enolase | 86.44 | 99.77 | ABP90468 |
| IADDBMHP_1 | 2184254 | 2182362 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.58 | 98.90 | ABP91129 |
| IADDBMHP_1 | 1266881 | 1268590 | PGM | 0.0 | phosphoglucomutase | 84.76 | 99.65 | ACH87041 |
| IADDBMHP_1 | 63934 | 65025 | recA | 0.0 | DNA recombination and repair | 84.64 | 95.36 | AAL00560 |
| IADDBMHP_1 | 2042128 | 2043138 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| IADDBMHP_1 | 1134766 | 1136127 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.67 | 99.56 | ABP90420 |
| IADDBMHP_1 | 634716 | 635606 | bglB | 1.27e-176 | putative phospho--glucosidase | 87.54 | 99.66 | AAK33487 |
| IADDBMHP_1 | 1269613 | 1268756 | metF | 3.31e-169 | methionine biosynthesis enzymes | 88.11 | 99.31 | AAK74739 |
| IADDBMHP_1 | 1226905 | 1227855 | SP_0676 | 4.28e-169 | transcription facot | 81.39 | 98.45 | AAK74821 |
| IADDBMHP_1 | 995541 | 996245 | covR | 3.52e-132 | responder protein | 86.38 | 100.00 | AAK71319 |
| IADDBMHP_1 | 1385740 | 1385069 | rr01 | 4.75e-126 | response regulator | 84.82 | 99.56 | CAB54566 |
| IADDBMHP_1 | 1262214 | 1261543 | ciaR | 5.58e-123 | two component system response regulator | 85.71 | 99.12 | AIK75708 |
| IADDBMHP_1 | 1262214 | 1261546 | CiaR | 7.56e-123 | two-component response regulator | 86.55 | 99.55 | AAK74935 |
| IADDBMHP_1 | 995541 | 996245 | walR | 5.79e-122 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| IADDBMHP_1 | 65199 | 65594 | SpxA2 | 2.18e-74 | transcriptional regulator | 91.67 | 100.00 | ERL21461 |
| IADDBMHP_1 | 1123292 | 1122891 | SpxA1 | 4.53e-69 | transcriptional regulator | 82.84 | 100.00 | ERL19273 |
| IADDBMHP_1 | 118883 | 119296 | GrpE | 1.72e-66 | protein grpE | 81.88 | 80.59 | ABP89267 |
| IADDBMHP_1 | 139147 | 139638 | RopE (M5005_Spy_1611) | 1.07e-71 | probable DNA-directed RNA polymerase subunit delta | 82.93 | 85.86 | AAK34603 |
| IADDBMHP_1 | 1869745 | 1872045 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.09 | 98.08 | MYN69560 |
| IADDBMHP_1 | 2077268 | 2076249 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 85.88 | 100.00 | ABJ55451 |
| IADDBMHP_1 | 282571 | 283020 | CovR | 2.07e-98 | serves to repress GAS virulence factor-encoding genes | 80.67 | 65.35 | ACE75886 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| IADDBMHP_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| IADDBMHP_1 | 923591 | 966087 | False | Siphoviridae | VOG0275, VOG0682, VOG4602, VOG6127, VOG3622, VOG8337, VOG11077, VOG4552, VOG3478, VOG0651, VOG5996, VOG4566, VOG0189, VOG3430, VOG1309, VOG0685, VOG0226, VOG4693, VOG0655, VOG4567, VOG0657, VOG0044, VOG0658, VOG0198, VOG4841, VOG4581, VOG1886, VOG0202, VOG4556, VOG4573, VOG4553, VOG0204, VOG0205, VOG0207, VOG4586, VOG0209, VOG6163, VOG4605, VOG4599, VOG0647, VOG0648, VOG7888, VOG0054, VOG5034, VOG7557, VOG4025, VOG10230, VOG0866 |
Phigaro v2.4.0 (Database: Jan. 2024 release)