Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 20 | 34 | 39.45 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| FIGPJKLC_4 | 62436 | 63287 | rfbD | 0.0 | Capsule | Immune modulation | 95.31 | 100.00 | WP_014621820 |
| FIGPJKLC_19 | 58975 | 59706 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 94.40 | 100.00 | WP_011227248 |
| FIGPJKLC_19 | 58975 | 59706 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 93.72 | 100.00 | WP_011226048 |
| FIGPJKLC_19 | 58975 | 59706 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 93.44 | 100.00 | WP_011681176 |
| FIGPJKLC_4 | 68615 | 70371 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 93.17 | 98.43 | WP_011226325 |
| FIGPJKLC_4 | 64609 | 65565 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 92.48 | 100.00 | WP_011226328 |
| FIGPJKLC_4 | 65549 | 66358 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 92.36 | 99.88 | WP_002948020 |
| FIGPJKLC_4 | 66358 | 67563 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 92.12 | 100.00 | WP_011226326 |
| FIGPJKLC_4 | 63464 | 64612 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 91.56 | 99.91 | WP_041828290 |
| FIGPJKLC_19 | 57514 | 58974 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 91.40 | 99.86 | WP_011681177 |
| FIGPJKLC_4 | 67584 | 68618 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 91.10 | 99.15 | WP_002948022 |
| FIGPJKLC_14 | 32507 | 33100 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 91.08 | 100.00 | WP_011226149 |
| FIGPJKLC_6 | 301944 | 303602 | fbp54 | 0.0 | FBPs | Adherence | 91.02 | 99.94 | WP_011227179 |
| FIGPJKLC_14 | 32507 | 33100 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 90.91 | 100.00 | WP_011226149 |
| FIGPJKLC_14 | 32507 | 33100 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 90.91 | 100.00 | WP_011226149 |
| FIGPJKLC_19 | 57514 | 58974 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 90.78 | 100.00 | WP_011226049 |
| FIGPJKLC_19 | 57514 | 58974 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 90.10 | 100.00 | WP_041827043 |
| FIGPJKLC_4 | 9601 | 10506 | cbpD | 0.0 | Autolysin | Exoenzyme | 89.96 | 93.50 | WP_082302295 |
| FIGPJKLC_19 | 59715 | 60407 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011226047 |
| FIGPJKLC_19 | 59715 | 60407 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 89.61 | 100.00 | WP_011227247 |
| FIGPJKLC_19 | 59715 | 60407 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.47 | 100.00 | WP_011681175 |
| FIGPJKLC_14 | 197280 | 198583 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| FIGPJKLC_18 | 19352 | 20365 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 85.67 | 99.90 | WP_002986042 |
| FIGPJKLC_6 | 152037 | 152798 | srtA | 0.0 | Sortase A | Exoenzyme | 84.40 | 99.87 | - |
| FIGPJKLC_14 | 31191 | 32237 | rfbB | 0.0 | Capsule | Immune modulation | 83.49 | 99.90 | WP_002263087 |
| FIGPJKLC_21 | 7763 | 9046 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.84 | 99.61 | WP_000107753 |
| FIGPJKLC_14 | 33100 | 33969 | rfbA | 0.0 | Capsule | Immune modulation | 80.28 | 99.77 | WP_002904719 |
| FIGPJKLC_19 | 60417 | 61087 | STU_RS14635 | 9.38e-150 | Capsule | Immune modulation | 81.13 | 90.28 | WP_011226046 |
| FIGPJKLC_19 | 60417 | 61087 | STER_RS05305 | 4.36e-148 | Capsule | Immune modulation | 80.98 | 90.28 | WP_011681174 |
| FIGPJKLC_19 | 60417 | 61087 | STR_RS05250 | 4.43e-138 | Capsule | Immune modulation | 80.09 | 89.20 | WP_011227246 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| FIGPJKLC_6 | 149348 | 148365 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 96.95 | 100.00 | AAK75326 |
| FIGPJKLC_6 | 160935 | 162008 | MntE | 0.0 | manganese homeostasis | 96.09 | 99.72 | ABF32167 |
| FIGPJKLC_16 | 13106 | 10800 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 94.41 | 99.22 | AAK74619 |
| FIGPJKLC_6 | 11868 | 10387 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 93.32 | 100.00 | ABJ54480 |
| FIGPJKLC_14 | 288867 | 287899 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| FIGPJKLC_6 | 180476 | 182722 | metE | 0.0 | methionine biosynthesis enzymes | 92.79 | 100.00 | AAK74738 |
| FIGPJKLC_5 | 24526 | 23555 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 91.67 | 100.00 | ABF36968 |
| FIGPJKLC_6 | 99602 | 106075 | PrtA | 0.0 | serine protease | 91.39 | 100.61 | ABJ55268 |
| FIGPJKLC_14 | 59344 | 57614 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 89.95 | 100.00 | AAK34199 |
| FIGPJKLC_4 | 50260 | 52248 | uvrB | 0.0 | excinuclease ABC, B subunit | 89.59 | 100.00 | AE014259_2 |
| FIGPJKLC_2 | 9822 | 10973 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| FIGPJKLC_23 | 30851 | 32329 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.83 | 100.00 | ADE32434 |
| FIGPJKLC_14 | 198583 | 197282 | Eno | 0.0 | enolase | 86.44 | 99.77 | ABP90468 |
| FIGPJKLC_23 | 47613 | 49505 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.74 | 98.90 | ABP91129 |
| FIGPJKLC_1 | 14004 | 15095 | recA | 0.0 | DNA recombination and repair | 84.91 | 95.36 | AAL00560 |
| FIGPJKLC_6 | 185640 | 183931 | PGM | 0.0 | phosphoglucomutase | 84.59 | 99.65 | ACH87041 |
| FIGPJKLC_23 | 197749 | 196739 | pdh | 0.0 | pyruvate dehydrogenase | 83.38 | 99.70 | ABP91006 |
| FIGPJKLC_6 | 317528 | 316167 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.89 | 99.56 | ABP90420 |
| FIGPJKLC_14 | 212997 | 212107 | bglB | 3.68e-178 | putative phospho--glucosidase | 87.88 | 99.66 | AAK33487 |
| FIGPJKLC_6 | 225612 | 224662 | SP_0676 | 5.46e-170 | transcription facot | 81.39 | 98.45 | AAK74821 |
| FIGPJKLC_6 | 182912 | 183769 | metF | 4.22e-168 | methionine biosynthesis enzymes | 86.71 | 99.31 | AAK74739 |
| FIGPJKLC_19 | 25188 | 25892 | covR | 3.27e-127 | responder protein | 85.53 | 100.00 | AAK71319 |
| FIGPJKLC_6 | 81463 | 82134 | rr01 | 7.95e-127 | response regulator | 84.82 | 99.56 | CAB54566 |
| FIGPJKLC_6 | 190308 | 190979 | ciaR | 3.55e-125 | two component system response regulator | 86.16 | 99.12 | AIK75708 |
| FIGPJKLC_6 | 190308 | 190976 | CiaR | 6.56e-125 | two-component response regulator | 87.44 | 99.55 | AAK74935 |
| FIGPJKLC_10 | 58792 | 58106 | CovR | 2.54e-121 | serves to repress GAS virulence factor-encoding genes | 82.10 | 100.00 | ACE75886 |
| FIGPJKLC_19 | 25188 | 25892 | walR | 7.43e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| FIGPJKLC_1 | 15269 | 15664 | SpxA2 | 2.05e-76 | transcriptional regulator | 91.67 | 100.00 | ERL21461 |
| FIGPJKLC_6 | 328985 | 329386 | SpxA1 | 2.36e-69 | transcriptional regulator | 82.09 | 100.00 | ERL19273 |
| FIGPJKLC_8 | 11963 | 11535 | GrpE | 3.79e-69 | protein grpE | 80.42 | 83.53 | ABP89267 |
| FIGPJKLC_10 | 35588 | 35301 | spr0479 | 2.18e-48 | essential gene | 85.42 | 98.97 | AAK99283 |
| FIGPJKLC_15 | 27221 | 26967 | spr1327 | 1.39e-46 | essential gene | 94.12 | 100.00 | AAL00131 |
| FIGPJKLC_23 | 111982 | 111719 | spr0175 | 1.21e-42 | pathogenitcity related | 85.23 | 100.00 | AAK98979 |
| FIGPJKLC_23 | 111157 | 110891 | spr0177 | 2.68e-41 | essential gene | 83.15 | 88.12 | AAK98981 |
| FIGPJKLC_21 | 9213 | 9704 | RopE (M5005_Spy_1611) | 6.61e-73 | probable DNA-directed RNA polymerase subunit delta | 83.54 | 85.86 | AAK34603 |
| FIGPJKLC_16 | 13106 | 10806 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.22 | 98.08 | MYN69560 |
| FIGPJKLC_23 | 161077 | 162096 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 85.88 | 100.00 | ABJ55451 |
| FIGPJKLC_6 | 288959 | 289498 | pnuC | 4.86e-94 | NAD salvage pathway importer | 83.89 | 66.91 | AAK75931 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| FIGPJKLC_1 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_2 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_3 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_4 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_5 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_6 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_7 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_8 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_9 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_10 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_11 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_12 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_13 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_14 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_15 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_16 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_17 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_18 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_19 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_20 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_21 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_22 | 0.0 | 1.0 | 0.0 |
| FIGPJKLC_23 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)