Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| PJKPJGJL_1 | 1122850 | 1123443 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| PJKPJGJL_1 | 996534 | 997994 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 99.93 | 100.00 | WP_011681177 |
| PJKPJGJL_1 | 1122850 | 1123443 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| PJKPJGJL_1 | 1335489 | 1336298 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_002948020 |
| PJKPJGJL_1 | 1123443 | 1124312 | rfbA | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011681286 |
| PJKPJGJL_1 | 1122850 | 1123443 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| PJKPJGJL_1 | 877892 | 879550 | fbp54 | 0.0 | FBPs | Adherence | 99.64 | 100.00 | WP_011227179 |
| PJKPJGJL_1 | 1336282 | 1337238 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226328 |
| PJKPJGJL_1 | 43710 | 44549 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| PJKPJGJL_1 | 1331416 | 1333200 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.44 | 100.00 | WP_011226325 |
| PJKPJGJL_1 | 1334284 | 1335489 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.17 | 100.00 | WP_011226326 |
| PJKPJGJL_1 | 1343425 | 1344276 | rfbD | 0.0 | Capsule | Immune modulation | 99.06 | 100.00 | WP_014621820 |
| PJKPJGJL_1 | 995802 | 996533 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011681176 |
| PJKPJGJL_1 | 1159631 | 1160392 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| PJKPJGJL_1 | 1337235 | 1338383 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 98.78 | 100.00 | WP_041828290 |
| PJKPJGJL_1 | 995802 | 996533 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011227248 |
| PJKPJGJL_1 | 995802 | 996533 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011226048 |
| PJKPJGJL_1 | 1063876 | 1064669 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.24 | 100.25 | - |
| PJKPJGJL_1 | 984370 | 985785 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 98.23 | 100.00 | WP_011681165 |
| PJKPJGJL_1 | 994351 | 995091 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.11 | 100.00 | WP_011226046 |
| PJKPJGJL_1 | 994351 | 995091 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.71 | 100.00 | WP_011681174 |
| PJKPJGJL_1 | 996534 | 997994 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.40 | 100.21 | WP_011226049 |
| PJKPJGJL_1 | 994356 | 995091 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.15 | 98.13 | WP_011227246 |
| PJKPJGJL_1 | 992927 | 994294 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 97.00 | 100.00 | WP_011226045 |
| PJKPJGJL_1 | 996534 | 997994 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.85 | 100.21 | WP_041827043 |
| PJKPJGJL_1 | 995101 | 995793 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.38 | 100.00 | WP_011227247 |
| PJKPJGJL_1 | 995101 | 995793 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.38 | 100.00 | WP_011226047 |
| PJKPJGJL_1 | 1333197 | 1334264 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 95.27 | 101.14 | WP_002948022 |
| PJKPJGJL_1 | 992929 | 994294 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.58 | 99.85 | WP_011681173 |
| PJKPJGJL_1 | 995101 | 995793 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 90.48 | 100.00 | WP_011681175 |
| PJKPJGJL_1 | 1341048 | 1342322 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 89.42 | 99.92 | WP_011226331 |
| PJKPJGJL_1 | 597192 | 598495 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.02 | 99.46 | WP_000022832 |
| PJKPJGJL_1 | 1629811 | 1630821 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| PJKPJGJL_1 | 139911 | 141194 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.81 | 99.77 | WP_000107753 |
| PJKPJGJL_1 | 1121375 | 1122421 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| PJKPJGJL_1 | 981967 | 982550 | SPD_RS01775 | 1.08e-151 | Capsule | Immune modulation | 83.59 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| PJKPJGJL_1 | 1163079 | 1164062 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| PJKPJGJL_1 | 716461 | 717534 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| PJKPJGJL_1 | 1506833 | 1509136 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| PJKPJGJL_1 | 513556 | 514524 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| PJKPJGJL_1 | 744781 | 747027 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| PJKPJGJL_1 | 1233391 | 1234872 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.70 | 100.00 | ABJ54480 |
| PJKPJGJL_1 | 63341 | 64339 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| PJKPJGJL_1 | 27227 | 28198 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| PJKPJGJL_1 | 1392816 | 1391665 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| PJKPJGJL_1 | 1357453 | 1355465 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| PJKPJGJL_1 | 1146880 | 1145150 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| PJKPJGJL_1 | 1839498 | 1838020 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| PJKPJGJL_1 | 597192 | 598493 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| PJKPJGJL_1 | 1824310 | 1822418 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| PJKPJGJL_1 | 749952 | 748243 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| PJKPJGJL_1 | 1673208 | 1674218 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| PJKPJGJL_1 | 901404 | 900043 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| PJKPJGJL_1 | 1723552 | 1721660 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| PJKPJGJL_1 | 582756 | 583646 | bglB | 5.25e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| PJKPJGJL_1 | 822795 | 821857 | SP_0676 | 2.35e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| PJKPJGJL_1 | 747219 | 748076 | metF | 1.53e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| PJKPJGJL_1 | 1036196 | 1035492 | covR | 4.37e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| PJKPJGJL_1 | 1214416 | 1213745 | rr01 | 3.00e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| PJKPJGJL_1 | 1036196 | 1035492 | walR | 1.84e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| PJKPJGJL_1 | 292939 | 293625 | CovR | 1.00e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| PJKPJGJL_1 | 753906 | 754574 | CiaR | 2.02e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| PJKPJGJL_1 | 753906 | 754577 | ciaR | 1.99e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| PJKPJGJL_1 | 64615 | 64989 | SpxA2 | 1.15e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| PJKPJGJL_1 | 912766 | 913167 | SpxA1 | 3.76e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| PJKPJGJL_1 | 141352 | 141852 | RopE (M5005_Spy_1611) | 4.91e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| PJKPJGJL_1 | 1506833 | 1509130 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| PJKPJGJL_1 | 1709092 | 1708073 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| PJKPJGJL_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)