Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| HKBGHNIH_1 | 936103 | 936972 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| HKBGHNIH_1 | 935510 | 936103 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| HKBGHNIH_1 | 1153003 | 1153812 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| HKBGHNIH_1 | 935510 | 936103 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| HKBGHNIH_1 | 1153796 | 1154752 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| HKBGHNIH_1 | 1154749 | 1155897 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| HKBGHNIH_1 | 935510 | 936103 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| HKBGHNIH_1 | 1159393 | 1160244 | rfbD | 0.0 | Capsule | Immune modulation | 99.65 | 100.00 | WP_014621820 |
| HKBGHNIH_1 | 727613 | 729271 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| HKBGHNIH_1 | 1151798 | 1153003 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226326 |
| HKBGHNIH_1 | 1148942 | 1150726 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226325 |
| HKBGHNIH_1 | 1156006 | 1157016 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226330 |
| HKBGHNIH_1 | 1150723 | 1151778 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.34 | 100.00 | WP_002948022 |
| HKBGHNIH_1 | 633580 | 634995 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 99.15 | 100.00 | WP_011681165 |
| HKBGHNIH_1 | 972291 | 973052 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| HKBGHNIH_1 | 1705922 | 1706761 | cbpD | 0.0 | Autolysin | Exoenzyme | 98.69 | 100.00 | WP_011226733 |
| HKBGHNIH_1 | 876438 | 877226 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.48 | 99.75 | - |
| HKBGHNIH_1 | 608676 | 609407 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011226048 |
| HKBGHNIH_1 | 608676 | 609407 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.09 | 100.00 | WP_011681176 |
| HKBGHNIH_1 | 608676 | 609407 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.68 | 100.00 | WP_011227248 |
| HKBGHNIH_1 | 1157019 | 1158290 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| HKBGHNIH_1 | 607215 | 608675 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.06 | 100.00 | WP_011681177 |
| HKBGHNIH_1 | 610118 | 610858 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.03 | 100.00 | WP_011681174 |
| HKBGHNIH_1 | 610118 | 610858 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 96.36 | 100.00 | WP_011226046 |
| HKBGHNIH_1 | 607215 | 608675 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.30 | 100.21 | WP_011226049 |
| HKBGHNIH_1 | 607215 | 608675 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.17 | 100.21 | WP_041827043 |
| HKBGHNIH_1 | 610118 | 610853 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 96.06 | 98.13 | WP_011227246 |
| HKBGHNIH_1 | 610915 | 612278 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 95.53 | 99.71 | WP_011226045 |
| HKBGHNIH_1 | 609416 | 610108 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.25 | 99.86 | WP_011227247 |
| HKBGHNIH_1 | 609416 | 610108 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.25 | 99.86 | WP_011226047 |
| HKBGHNIH_1 | 610915 | 612282 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.52 | 99.93 | WP_011681173 |
| HKBGHNIH_1 | 609416 | 610108 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.32 | 100.00 | WP_011681175 |
| HKBGHNIH_1 | 414728 | 416031 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| HKBGHNIH_1 | 1447214 | 1448224 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.36 | 99.80 | WP_002986042 |
| HKBGHNIH_1 | 1810293 | 1811576 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| HKBGHNIH_1 | 934035 | 935081 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| HKBGHNIH_1 | 975739 | 976722 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| HKBGHNIH_1 | 522369 | 523442 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| HKBGHNIH_1 | 1325205 | 1327508 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| HKBGHNIH_1 | 331097 | 332065 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| HKBGHNIH_1 | 1050397 | 1051878 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| HKBGHNIH_1 | 550746 | 552992 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| HKBGHNIH_1 | 1725552 | 1726544 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| HKBGHNIH_1 | 1689436 | 1690407 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| HKBGHNIH_1 | 1211514 | 1210363 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| HKBGHNIH_1 | 1175213 | 1173225 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| HKBGHNIH_1 | 959544 | 957814 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| HKBGHNIH_1 | 1651213 | 1649735 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| HKBGHNIH_1 | 414728 | 416029 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| HKBGHNIH_1 | 1636026 | 1634134 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| HKBGHNIH_1 | 852809 | 854518 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| HKBGHNIH_1 | 1490499 | 1491509 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| HKBGHNIH_1 | 699718 | 701079 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| HKBGHNIH_1 | 1540861 | 1538969 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| HKBGHNIH_1 | 400292 | 401182 | bglB | 5.32e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| HKBGHNIH_1 | 783073 | 784008 | SP_0676 | 7.48e-168 | transcription facot | 81.73 | 96.89 | AAK74821 |
| HKBGHNIH_1 | 553184 | 554041 | metF | 1.55e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| HKBGHNIH_1 | 570365 | 571069 | covR | 4.43e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| HKBGHNIH_1 | 1031422 | 1030751 | rr01 | 3.04e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| HKBGHNIH_1 | 570365 | 571069 | walR | 1.87e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| HKBGHNIH_1 | 111746 | 112432 | CovR | 1.04e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| HKBGHNIH_1 | 848855 | 848187 | CiaR | 2.05e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| HKBGHNIH_1 | 848855 | 848184 | ciaR | 2.01e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| HKBGHNIH_1 | 1726841 | 1727236 | SpxA2 | 3.75e-74 | transcriptional regulator | 90.91 | 100.00 | ERL21461 |
| HKBGHNIH_1 | 688358 | 687957 | SpxA1 | 3.81e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| HKBGHNIH_1 | 1811734 | 1812234 | RopE (M5005_Spy_1611) | 4.98e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| HKBGHNIH_1 | 1325205 | 1327502 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| HKBGHNIH_1 | 1526407 | 1525388 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| HKBGHNIH_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)