Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 20 | 29 | 35.23 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| KKNCGCPN_1 | 2031820 | 2032535 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 96.51 | 99.86 | WP_011681442 |
| KKNCGCPN_1 | 2030850 | 2031818 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 94.94 | 100.00 | WP_011681443 |
| KKNCGCPN_1 | 2027660 | 2028511 | rfbD | 0.0 | Capsule | Immune modulation | 94.84 | 100.00 | WP_014621820 |
| KKNCGCPN_1 | 560332 | 561697 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.51 | 99.85 | WP_011681173 |
| KKNCGCPN_1 | 561754 | 562494 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 94.47 | 100.00 | WP_011681174 |
| KKNCGCPN_1 | 560330 | 561697 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.22 | 100.00 | WP_011226045 |
| KKNCGCPN_1 | 561754 | 562494 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 93.93 | 100.00 | WP_011226046 |
| KKNCGCPN_1 | 563937 | 565397 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 93.84 | 100.14 | WP_011226049 |
| KKNCGCPN_1 | 563937 | 565397 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 93.78 | 99.93 | WP_011681177 |
| KKNCGCPN_1 | 561759 | 562494 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 93.48 | 98.13 | WP_011227246 |
| KKNCGCPN_1 | 563937 | 565397 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 92.95 | 100.14 | WP_041827043 |
| KKNCGCPN_1 | 2032881 | 2033657 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 92.79 | 100.00 | WP_011681440 |
| KKNCGCPN_1 | 2028630 | 2029883 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 92.34 | 99.44 | WP_011681445 |
| KKNCGCPN_1 | 563205 | 563936 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 91.94 | 100.00 | WP_011226048 |
| KKNCGCPN_1 | 739657 | 740526 | rfbA | 0.0 | Capsule | Immune modulation | 91.15 | 100.00 | WP_011681286 |
| KKNCGCPN_1 | 451128 | 452786 | fbp54 | 0.0 | FBPs | Adherence | 91.08 | 99.94 | WP_011227179 |
| KKNCGCPN_1 | 563205 | 563936 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 90.98 | 100.00 | WP_011681176 |
| KKNCGCPN_1 | 563205 | 563936 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 90.98 | 100.00 | WP_011227248 |
| KKNCGCPN_1 | 1475469 | 1476308 | cbpD | 0.0 | Autolysin | Exoenzyme | 90.95 | 100.00 | WP_011226733 |
| KKNCGCPN_1 | 739064 | 739657 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 90.91 | 100.00 | WP_011226149 |
| KKNCGCPN_1 | 739064 | 739657 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 90.74 | 100.00 | WP_011226149 |
| KKNCGCPN_1 | 739064 | 739657 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 90.74 | 100.00 | WP_011226149 |
| KKNCGCPN_1 | 1732011 | 1733021 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 88.35 | 99.80 | WP_002986042 |
| KKNCGCPN_1 | 914866 | 916169 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.24 | 99.54 | WP_000022832 |
| KKNCGCPN_1 | 562504 | 563196 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 88.18 | 99.86 | WP_011227247 |
| KKNCGCPN_1 | 562504 | 563196 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 88.18 | 99.86 | WP_011226047 |
| KKNCGCPN_1 | 562504 | 563196 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 87.75 | 99.86 | WP_011681175 |
| KKNCGCPN_1 | 309557 | 310318 | srtA | 0.0 | Sortase A | Exoenzyme | 84.40 | 99.87 | - |
| KKNCGCPN_1 | 737745 | 738791 | rfbB | 0.0 | Capsule | Immune modulation | 83.59 | 99.90 | WP_002263087 |
| KKNCGCPN_1 | 1385127 | 1386410 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.61 | 99.61 | WP_000107753 |
| KKNCGCPN_1 | 550607 | 551190 | SPD_RS01775 | 2.67e-148 | Capsule | Immune modulation | 83.25 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| KKNCGCPN_1 | 306869 | 305886 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 96.34 | 100.00 | AAK75326 |
| KKNCGCPN_1 | 318453 | 319526 | MntE | 0.0 | manganese homeostasis | 95.53 | 99.72 | ABF32167 |
| KKNCGCPN_1 | 1851983 | 1849677 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 94.41 | 99.22 | AAK74619 |
| KKNCGCPN_1 | 159762 | 158281 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 93.52 | 100.00 | ABJ54480 |
| KKNCGCPN_1 | 337515 | 339761 | metE | 0.0 | methionine biosynthesis enzymes | 93.19 | 100.00 | AAK74738 |
| KKNCGCPN_1 | 1007321 | 1006353 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| KKNCGCPN_1 | 1490728 | 1489757 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 91.67 | 100.00 | ABF36968 |
| KKNCGCPN_1 | 765911 | 764181 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 90.12 | 100.00 | AAK34199 |
| KKNCGCPN_1 | 1985825 | 1986976 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.58 | 99.74 | AAL00050 |
| KKNCGCPN_1 | 2014219 | 2016207 | uvrB | 0.0 | excinuclease ABC, B subunit | 89.44 | 100.00 | AE014259_2 |
| KKNCGCPN_1 | 1527653 | 1529131 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.83 | 100.00 | ADE32434 |
| KKNCGCPN_1 | 916169 | 914868 | Eno | 0.0 | enolase | 86.44 | 99.77 | ABP90468 |
| KKNCGCPN_1 | 1544602 | 1546494 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.58 | 98.90 | ABP91129 |
| KKNCGCPN_1 | 342683 | 340974 | PGM | 0.0 | phosphoglucomutase | 84.76 | 99.65 | ACH87041 |
| KKNCGCPN_1 | 1454435 | 1453344 | recA | 0.0 | DNA recombination and repair | 84.64 | 95.36 | AAL00560 |
| KKNCGCPN_1 | 1677412 | 1676402 | pdh | 0.0 | pyruvate dehydrogenase | 83.38 | 99.70 | ABP91006 |
| KKNCGCPN_1 | 466554 | 465193 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.67 | 99.56 | ABP90420 |
| KKNCGCPN_1 | 930589 | 929699 | bglB | 2.62e-177 | putative phospho--glucosidase | 87.88 | 99.66 | AAK33487 |
| KKNCGCPN_1 | 381840 | 380890 | SP_0676 | 2.62e-169 | transcription facot | 81.39 | 98.45 | AAK74821 |
| KKNCGCPN_1 | 339951 | 340808 | metF | 9.14e-168 | methionine biosynthesis enzymes | 87.06 | 99.31 | AAK74739 |
| KKNCGCPN_1 | 245581 | 246252 | rr01 | 4.53e-126 | response regulator | 84.82 | 99.56 | CAB54566 |
| KKNCGCPN_1 | 611036 | 610332 | covR | 9.40e-126 | responder protein | 85.53 | 100.00 | AAK71319 |
| KKNCGCPN_1 | 346653 | 347324 | ciaR | 2.02e-124 | two component system response regulator | 86.16 | 99.12 | AIK75708 |
| KKNCGCPN_1 | 346653 | 347321 | CiaR | 3.74e-124 | two-component response regulator | 87.44 | 99.55 | AAK74935 |
| KKNCGCPN_1 | 611036 | 610332 | walR | 2.14e-119 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| KKNCGCPN_1 | 1247082 | 1246396 | CovR | 2.96e-118 | serves to repress GAS virulence factor-encoding genes | 81.22 | 100.00 | ACE75886 |
| KKNCGCPN_1 | 1453169 | 1452774 | SpxA2 | 2.08e-74 | transcriptional regulator | 91.67 | 100.00 | ERL21461 |
| KKNCGCPN_1 | 478021 | 478422 | SpxA1 | 1.90e-68 | transcriptional regulator | 82.09 | 100.00 | ERL19273 |
| KKNCGCPN_1 | 1399420 | 1399007 | GrpE | 1.64e-66 | protein grpE | 81.88 | 80.59 | ABP89267 |
| KKNCGCPN_1 | 1384960 | 1384469 | RopE (M5005_Spy_1611) | 1.02e-71 | probable DNA-directed RNA polymerase subunit delta | 82.93 | 85.86 | AAK34603 |
| KKNCGCPN_1 | 1851983 | 1849683 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 83.22 | 98.08 | MYN69560 |
| KKNCGCPN_1 | 1640996 | 1642015 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 97.35 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| KKNCGCPN_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)