Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 15 | 36 | 39.00 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| GBIBDABG_24 | 46079 | 47539 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 95.89 | 100.00 | WP_011681177 |
| GBIBDABG_24 | 46079 | 47539 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 95.55 | 100.21 | WP_011226049 |
| GBIBDABG_22 | 37928 | 38779 | rfbD | 0.0 | Capsule | Immune modulation | 95.07 | 100.00 | WP_014621820 |
| GBIBDABG_24 | 48982 | 49722 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 95.01 | 100.00 | WP_011681174 |
| GBIBDABG_24 | 46079 | 47539 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 94.87 | 100.21 | WP_041827043 |
| GBIBDABG_24 | 48982 | 49722 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 94.33 | 100.00 | WP_011226046 |
| GBIBDABG_11 | 467765 | 468811 | rfbB | 0.0 | Capsule | Immune modulation | 94.17 | 100.00 | WP_002947383 |
| GBIBDABG_24 | 47540 | 48271 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 94.13 | 100.00 | WP_011681176 |
| GBIBDABG_24 | 47540 | 48271 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 93.99 | 100.00 | WP_011226048 |
| GBIBDABG_24 | 49779 | 51146 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 93.93 | 100.00 | WP_011226045 |
| GBIBDABG_24 | 48982 | 49717 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 93.75 | 98.13 | WP_011227246 |
| GBIBDABG_24 | 49779 | 51144 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 93.63 | 99.85 | WP_011681173 |
| GBIBDABG_24 | 47540 | 48271 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 93.31 | 100.00 | WP_011227248 |
| GBIBDABG_11 | 466969 | 467562 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 91.58 | 100.00 | WP_011226149 |
| GBIBDABG_11 | 466969 | 467562 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 91.41 | 100.00 | WP_011226149 |
| GBIBDABG_11 | 466969 | 467562 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 91.41 | 100.00 | WP_011226149 |
| GBIBDABG_11 | 466100 | 466969 | rfbA | 0.0 | Capsule | Immune modulation | 90.81 | 100.00 | WP_011681286 |
| GBIBDABG_19 | 115023 | 116680 | fbp54 | 0.0 | FBPs | Adherence | 90.60 | 99.88 | WP_011227179 |
| GBIBDABG_24 | 48280 | 48972 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 88.47 | 99.86 | WP_011227247 |
| GBIBDABG_24 | 48280 | 48972 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 88.47 | 99.86 | WP_011226047 |
| GBIBDABG_20 | 9215 | 10225 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 88.35 | 99.80 | WP_002986042 |
| GBIBDABG_11 | 288443 | 289746 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.24 | 99.54 | WP_000022832 |
| GBIBDABG_24 | 48280 | 48972 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 87.75 | 99.86 | WP_011681175 |
| GBIBDABG_11 | 103999 | 104895 | cbpD | 0.0 | Autolysin | Exoenzyme | 84.88 | 93.19 | WP_082302295 |
| GBIBDABG_2 | 43283 | 44044 | srtA | 0.0 | Sortase A | Exoenzyme | 84.16 | 99.74 | - |
| GBIBDABG_18 | 200031 | 201314 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.68 | 99.61 | WP_000107753 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| GBIBDABG_2 | 52173 | 53246 | MntE | 0.0 | manganese homeostasis | 96.09 | 99.72 | ABF32167 |
| GBIBDABG_2 | 40595 | 39612 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 96.04 | 100.00 | AAK75326 |
| GBIBDABG_4 | 54532 | 56838 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 94.41 | 99.22 | AAK74619 |
| GBIBDABG_21 | 73674 | 75155 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 93.32 | 100.00 | ABJ54480 |
| GBIBDABG_11 | 196863 | 197831 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| GBIBDABG_19 | 5527 | 7773 | metE | 0.0 | methionine biosynthesis enzymes | 92.52 | 100.00 | AAK74738 |
| GBIBDABG_6 | 36687 | 35716 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 91.67 | 100.00 | ABF36968 |
| GBIBDABG_21 | 9990 | 3442 | PrtA | 0.0 | serine protease | 90.35 | 101.73 | ABJ55268 |
| GBIBDABG_11 | 439235 | 440965 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 89.95 | 100.00 | AAK34199 |
| GBIBDABG_1 | 68025 | 69176 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.58 | 99.74 | AAL00050 |
| GBIBDABG_22 | 24665 | 26653 | uvrB | 0.0 | excinuclease ABC, B subunit | 89.29 | 100.00 | AE014259_2 |
| GBIBDABG_23 | 25732 | 27210 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| GBIBDABG_11 | 288443 | 289744 | Eno | 0.0 | enolase | 86.44 | 99.77 | ABP90468 |
| GBIBDABG_23 | 41056 | 42948 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.26 | 98.90 | ABP91129 |
| GBIBDABG_19 | 10694 | 8985 | PGM | 0.0 | phosphoglucomutase | 84.76 | 99.65 | ACH87041 |
| GBIBDABG_6 | 1894 | 803 | recA | 0.0 | DNA recombination and repair | 84.64 | 95.36 | AAL00560 |
| GBIBDABG_25 | 56220 | 55210 | pdh | 0.0 | pyruvate dehydrogenase | 82.79 | 99.70 | ABP91006 |
| GBIBDABG_19 | 130448 | 129087 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| GBIBDABG_11 | 274037 | 274927 | bglB | 7.29e-178 | putative phospho--glucosidase | 87.88 | 99.66 | AAK33487 |
| GBIBDABG_19 | 50709 | 49759 | SP_0676 | 2.68e-170 | transcription facot | 81.39 | 98.45 | AAK74821 |
| GBIBDABG_19 | 7963 | 8820 | metF | 9.94e-170 | methionine biosynthesis enzymes | 88.11 | 99.31 | AAK74739 |
| GBIBDABG_11 | 98514 | 99218 | NisK | 1.05e-130 | two-component signal-transduction systems | 91.06 | 100.00 | ABP89872 |
| GBIBDABG_11 | 97846 | 98526 | NisR | 7.09e-130 | two-component signal-transduction systems | 93.39 | 100.00 | ABP89873 |
| GBIBDABG_24 | 388 | 1092 | covR | 4.68e-127 | responder protein | 85.53 | 100.00 | AAK71319 |
| GBIBDABG_21 | 27823 | 27152 | rr01 | 9.09e-127 | response regulator | 84.38 | 99.56 | CAB54566 |
| GBIBDABG_19 | 15358 | 16029 | ciaR | 7.50e-125 | two component system response regulator | 85.71 | 99.12 | AIK75708 |
| GBIBDABG_19 | 15358 | 16026 | CiaR | 9.33e-125 | two-component response regulator | 87.00 | 99.55 | AAK74935 |
| GBIBDABG_24 | 388 | 1092 | walR | 1.06e-120 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| GBIBDABG_18 | 53779 | 53093 | CovR | 4.44e-120 | serves to repress GAS virulence factor-encoding genes | 81.66 | 100.00 | ACE75886 |
| GBIBDABG_6 | 629 | 234 | SpxA2 | 4.03e-76 | transcriptional regulator | 91.67 | 100.00 | ERL21461 |
| GBIBDABG_19 | 141917 | 142318 | SpxA1 | 1.86e-69 | transcriptional regulator | 82.09 | 100.00 | ERL19273 |
| GBIBDABG_8 | 6688 | 6284 | GrpE | 1.14e-68 | protein grpE | 82.96 | 78.82 | ABP89267 |
| GBIBDABG_18 | 30571 | 30284 | spr0479 | 4.30e-48 | essential gene | 85.42 | 98.97 | AAK99283 |
| GBIBDABG_11 | 164153 | 164407 | spr1327 | 2.69e-44 | essential gene | 92.94 | 100.00 | AAL00131 |
| GBIBDABG_23 | 80542 | 80279 | spr0175 | 6.01e-43 | pathogenitcity related | 85.23 | 100.00 | AAK98979 |
| GBIBDABG_23 | 79716 | 79450 | spr0177 | 1.05e-41 | essential gene | 83.15 | 88.12 | AAK98981 |
| GBIBDABG_18 | 199864 | 199373 | RopE (M5005_Spy_1611) | 9.84e-73 | probable DNA-directed RNA polymerase subunit delta | 82.93 | 85.86 | AAK34603 |
| GBIBDABG_4 | 54532 | 56832 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.97 | 98.08 | MYN69560 |
| GBIBDABG_25 | 19534 | 20553 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 97.35 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| GBIBDABG_1 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_2 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_3 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_4 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_5 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_6 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_7 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_8 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_9 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_10 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_11 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_12 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_13 | 1.0 | 0.0 | 1.0 |
| GBIBDABG_14 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_15 | 1.0 | 0.0 | 1.0 |
| GBIBDABG_16 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_17 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_18 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_19 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_20 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_21 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_22 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_23 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_24 | 0.0 | 1.0 | 0.0 |
| GBIBDABG_25 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)