Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| BIHGECFC_1 | 1132156 | 1132749 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| BIHGECFC_1 | 1005839 | 1007299 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 99.93 | 100.00 | WP_011681177 |
| BIHGECFC_1 | 1132156 | 1132749 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| BIHGECFC_1 | 1344802 | 1345611 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_002948020 |
| BIHGECFC_1 | 1132749 | 1133618 | rfbA | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011681286 |
| BIHGECFC_1 | 1132156 | 1132749 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| BIHGECFC_1 | 887197 | 888855 | fbp54 | 0.0 | FBPs | Adherence | 99.64 | 100.00 | WP_011227179 |
| BIHGECFC_1 | 1345595 | 1346551 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226328 |
| BIHGECFC_1 | 43649 | 44488 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| BIHGECFC_1 | 1340729 | 1342513 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.44 | 100.00 | WP_011226325 |
| BIHGECFC_1 | 1343597 | 1344802 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.17 | 100.00 | WP_011226326 |
| BIHGECFC_1 | 1352738 | 1353589 | rfbD | 0.0 | Capsule | Immune modulation | 99.06 | 100.00 | WP_014621820 |
| BIHGECFC_1 | 1005107 | 1005838 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.91 | 100.00 | WP_011681176 |
| BIHGECFC_1 | 1168942 | 1169703 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| BIHGECFC_1 | 1346548 | 1347696 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 98.78 | 100.00 | WP_041828290 |
| BIHGECFC_1 | 1005107 | 1005838 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011227248 |
| BIHGECFC_1 | 1005107 | 1005838 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011226048 |
| BIHGECFC_1 | 1073181 | 1073974 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.24 | 100.25 | - |
| BIHGECFC_1 | 993675 | 995090 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 98.23 | 100.00 | WP_011681165 |
| BIHGECFC_1 | 1003656 | 1004396 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.11 | 100.00 | WP_011226046 |
| BIHGECFC_1 | 1003656 | 1004396 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 97.71 | 100.00 | WP_011681174 |
| BIHGECFC_1 | 1005839 | 1007299 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.40 | 100.21 | WP_011226049 |
| BIHGECFC_1 | 1003661 | 1004396 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.15 | 98.13 | WP_011227246 |
| BIHGECFC_1 | 1002232 | 1003599 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 97.00 | 100.00 | WP_011226045 |
| BIHGECFC_1 | 1005839 | 1007299 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.85 | 100.21 | WP_041827043 |
| BIHGECFC_1 | 1004406 | 1005098 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.38 | 100.00 | WP_011227247 |
| BIHGECFC_1 | 1004406 | 1005098 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.38 | 100.00 | WP_011226047 |
| BIHGECFC_1 | 1342510 | 1343577 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 95.27 | 101.14 | WP_002948022 |
| BIHGECFC_1 | 1002234 | 1003599 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.58 | 99.85 | WP_011681173 |
| BIHGECFC_1 | 1004406 | 1005098 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 90.48 | 100.00 | WP_011681175 |
| BIHGECFC_1 | 1350361 | 1351635 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 89.42 | 99.92 | WP_011226331 |
| BIHGECFC_1 | 606491 | 607794 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.02 | 99.46 | WP_000022832 |
| BIHGECFC_1 | 1639127 | 1640137 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| BIHGECFC_1 | 145684 | 146967 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.81 | 99.77 | WP_000107753 |
| BIHGECFC_1 | 1130681 | 1131727 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| BIHGECFC_1 | 991272 | 991855 | SPD_RS01775 | 1.09e-151 | Capsule | Immune modulation | 83.59 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| BIHGECFC_1 | 1172390 | 1173373 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| BIHGECFC_1 | 725762 | 726835 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| BIHGECFC_1 | 1516146 | 1518449 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| BIHGECFC_1 | 522853 | 523821 | spr0084 | 0.0 | pathogenitcity related | 92.57 | 98.48 | AAK98888 |
| BIHGECFC_1 | 754082 | 756328 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| BIHGECFC_1 | 1242702 | 1244183 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 91.70 | 100.00 | ABJ54480 |
| BIHGECFC_1 | 63280 | 64278 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| BIHGECFC_1 | 27166 | 28137 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| BIHGECFC_1 | 1402129 | 1400978 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| BIHGECFC_1 | 1366766 | 1364778 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| BIHGECFC_1 | 1156191 | 1154461 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| BIHGECFC_1 | 1846167 | 1844689 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| BIHGECFC_1 | 606491 | 607792 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| BIHGECFC_1 | 1830978 | 1829086 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| BIHGECFC_1 | 759253 | 757544 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| BIHGECFC_1 | 1682525 | 1683535 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| BIHGECFC_1 | 910709 | 909348 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| BIHGECFC_1 | 1732869 | 1730977 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| BIHGECFC_1 | 592055 | 592945 | bglB | 5.27e-178 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| BIHGECFC_1 | 832100 | 831162 | SP_0676 | 2.36e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| BIHGECFC_1 | 756520 | 757377 | metF | 1.53e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| BIHGECFC_1 | 1045501 | 1044797 | covR | 4.39e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| BIHGECFC_1 | 1223727 | 1223056 | rr01 | 3.01e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| BIHGECFC_1 | 1045501 | 1044797 | walR | 1.85e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| BIHGECFC_1 | 298713 | 299399 | CovR | 1.01e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| BIHGECFC_1 | 763207 | 763875 | CiaR | 2.02e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| BIHGECFC_1 | 763207 | 763878 | ciaR | 1.99e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| BIHGECFC_1 | 64554 | 64928 | SpxA2 | 1.16e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| BIHGECFC_1 | 922071 | 922472 | SpxA1 | 1.48e-65 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| BIHGECFC_1 | 147125 | 147625 | RopE (M5005_Spy_1611) | 4.93e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| BIHGECFC_1 | 1516146 | 1518443 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| BIHGECFC_1 | 1718409 | 1717390 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| BIHGECFC_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)