Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| AAEAFEGH_1 | 1350048 | 1350857 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| AAEAFEGH_1 | 1350841 | 1351797 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| AAEAFEGH_1 | 1351794 | 1352942 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| AAEAFEGH_1 | 1356438 | 1357289 | rfbD | 0.0 | Capsule | Immune modulation | 99.65 | 100.00 | WP_014621820 |
| AAEAFEGH_1 | 866028 | 867686 | fbp54 | 0.0 | FBPs | Adherence | 99.64 | 100.00 | WP_011227179 |
| AAEAFEGH_1 | 1348843 | 1350048 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226326 |
| AAEAFEGH_1 | 43648 | 44487 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| AAEAFEGH_1 | 1353051 | 1354061 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226330 |
| AAEAFEGH_1 | 1347768 | 1348823 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.43 | 100.00 | WP_002948022 |
| AAEAFEGH_1 | 1111764 | 1112633 | rfbA | 0.0 | Capsule | Immune modulation | 99.42 | 100.00 | WP_011681286 |
| AAEAFEGH_1 | 1345987 | 1347771 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.38 | 100.00 | WP_011226325 |
| AAEAFEGH_1 | 1111171 | 1111764 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_011226149 |
| AAEAFEGH_1 | 1111171 | 1111764 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| AAEAFEGH_1 | 1111171 | 1111764 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| AAEAFEGH_1 | 986162 | 986857 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 98.99 | 100.29 | WP_011226047 |
| AAEAFEGH_1 | 986162 | 986857 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 98.42 | 100.29 | WP_011227247 |
| AAEAFEGH_1 | 1053539 | 1054332 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.24 | 100.25 | - |
| AAEAFEGH_1 | 986866 | 987597 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.22 | 100.00 | WP_011226048 |
| AAEAFEGH_1 | 987598 | 989058 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 98.02 | 100.00 | WP_011681177 |
| AAEAFEGH_1 | 986866 | 987597 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 97.95 | 100.00 | WP_011681176 |
| AAEAFEGH_1 | 976839 | 978254 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| AAEAFEGH_1 | 986866 | 987597 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.54 | 100.00 | WP_011227248 |
| AAEAFEGH_1 | 1354064 | 1355335 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| AAEAFEGH_1 | 987598 | 989058 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.26 | 100.21 | WP_011226049 |
| AAEAFEGH_1 | 1147965 | 1148728 | srtA | 0.0 | Sortase A | Exoenzyme | 97.12 | 100.13 | - |
| AAEAFEGH_1 | 987598 | 989058 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.30 | 100.21 | WP_041827043 |
| AAEAFEGH_1 | 985394 | 986152 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 95.52 | 100.94 | WP_011681174 |
| AAEAFEGH_1 | 985394 | 986152 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 95.39 | 100.94 | WP_011226046 |
| AAEAFEGH_1 | 983972 | 985337 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.24 | 99.85 | WP_011681173 |
| AAEAFEGH_1 | 985399 | 986152 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 94.56 | 99.07 | WP_011227246 |
| AAEAFEGH_1 | 983970 | 985337 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.01 | 100.00 | WP_011226045 |
| AAEAFEGH_1 | 986162 | 986857 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 88.94 | 100.29 | WP_011681175 |
| AAEAFEGH_1 | 613695 | 614998 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| AAEAFEGH_1 | 1647623 | 1648633 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.44 | 99.41 | WP_002986042 |
| AAEAFEGH_1 | 146492 | 147775 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| AAEAFEGH_1 | 1109695 | 1110741 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| AAEAFEGH_1 | 1151415 | 1152398 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| AAEAFEGH_1 | 719809 | 720882 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| AAEAFEGH_1 | 530010 | 530978 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| AAEAFEGH_1 | 1524409 | 1526712 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| AAEAFEGH_1 | 1246226 | 1247707 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| AAEAFEGH_1 | 741751 | 743997 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| AAEAFEGH_1 | 72260 | 73258 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| AAEAFEGH_1 | 27165 | 28136 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| AAEAFEGH_1 | 1409445 | 1408294 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| AAEAFEGH_1 | 1372257 | 1370269 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| AAEAFEGH_1 | 1135205 | 1133475 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| AAEAFEGH_1 | 1868985 | 1867507 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| AAEAFEGH_1 | 613695 | 614996 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| AAEAFEGH_1 | 1853796 | 1851904 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| AAEAFEGH_1 | 746922 | 745213 | PGM | 0.0 | phosphoglucomutase | 83.71 | 99.65 | ACH87041 |
| AAEAFEGH_1 | 1692112 | 1693122 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| AAEAFEGH_1 | 900838 | 899477 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| AAEAFEGH_1 | 1744156 | 1742264 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| AAEAFEGH_1 | 599260 | 600150 | bglB | 1.35e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| AAEAFEGH_1 | 807993 | 807055 | SP_0676 | 2.39e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| AAEAFEGH_1 | 744189 | 745046 | metF | 1.55e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| AAEAFEGH_1 | 1025859 | 1025155 | covR | 4.44e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| AAEAFEGH_1 | 1205034 | 1204363 | rr01 | 3.05e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| AAEAFEGH_1 | 1025859 | 1025155 | walR | 1.87e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| AAEAFEGH_1 | 304529 | 305215 | CovR | 1.02e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| AAEAFEGH_1 | 750876 | 751544 | CiaR | 2.05e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| AAEAFEGH_1 | 750876 | 751547 | ciaR | 2.02e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| AAEAFEGH_1 | 73534 | 73908 | SpxA2 | 1.17e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| AAEAFEGH_1 | 912198 | 912599 | SpxA1 | 4.86e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| AAEAFEGH_1 | 147933 | 148433 | RopE (M5005_Spy_1611) | 4.99e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| AAEAFEGH_1 | 1524409 | 1526706 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| AAEAFEGH_1 | 1729684 | 1728665 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| AAEAFEGH_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)