Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 29 | 38.29 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| KGMDKBNI_1 | 1356944 | 1357753 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| KGMDKBNI_1 | 1357737 | 1358693 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| KGMDKBNI_1 | 1358690 | 1359838 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| KGMDKBNI_1 | 1363334 | 1364185 | rfbD | 0.0 | Capsule | Immune modulation | 99.65 | 100.00 | WP_014621820 |
| KGMDKBNI_1 | 871858 | 873516 | fbp54 | 0.0 | FBPs | Adherence | 99.64 | 100.00 | WP_011227179 |
| KGMDKBNI_1 | 1355739 | 1356944 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226326 |
| KGMDKBNI_1 | 43691 | 44530 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| KGMDKBNI_1 | 1359947 | 1360957 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226330 |
| KGMDKBNI_1 | 1354664 | 1355719 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.43 | 100.00 | WP_002948022 |
| KGMDKBNI_1 | 1118655 | 1119524 | rfbA | 0.0 | Capsule | Immune modulation | 99.42 | 100.00 | WP_011681286 |
| KGMDKBNI_1 | 1352883 | 1354667 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.38 | 100.00 | WP_011226325 |
| KGMDKBNI_1 | 1118062 | 1118655 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.33 | 100.00 | WP_011226149 |
| KGMDKBNI_1 | 1118062 | 1118655 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| KGMDKBNI_1 | 1118062 | 1118655 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.16 | 100.00 | WP_011226149 |
| KGMDKBNI_1 | 991992 | 992687 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 99.14 | 100.29 | WP_011226047 |
| KGMDKBNI_1 | 991992 | 992687 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 98.56 | 100.29 | WP_011227247 |
| KGMDKBNI_1 | 1060430 | 1061223 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.24 | 100.25 | - |
| KGMDKBNI_1 | 992696 | 993427 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.22 | 100.00 | WP_011226048 |
| KGMDKBNI_1 | 993428 | 994888 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 98.02 | 100.00 | WP_011681177 |
| KGMDKBNI_1 | 992696 | 993427 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 97.95 | 100.00 | WP_011681176 |
| KGMDKBNI_1 | 982669 | 984084 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.88 | 100.00 | WP_011681165 |
| KGMDKBNI_1 | 1154858 | 1155619 | srtA | 0.0 | Sortase A | Exoenzyme | 97.64 | 100.00 | - |
| KGMDKBNI_1 | 992696 | 993427 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.54 | 100.00 | WP_011227248 |
| KGMDKBNI_1 | 1360960 | 1362231 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| KGMDKBNI_1 | 993428 | 994888 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.26 | 100.21 | WP_011226049 |
| KGMDKBNI_1 | 993428 | 994888 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 96.30 | 100.21 | WP_041827043 |
| KGMDKBNI_1 | 991224 | 991982 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 95.52 | 100.94 | WP_011681174 |
| KGMDKBNI_1 | 991224 | 991982 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 95.39 | 100.94 | WP_011226046 |
| KGMDKBNI_1 | 989802 | 991167 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.24 | 99.85 | WP_011681173 |
| KGMDKBNI_1 | 991229 | 991982 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 94.56 | 99.07 | WP_011227246 |
| KGMDKBNI_1 | 989800 | 991167 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.01 | 100.00 | WP_011226045 |
| KGMDKBNI_1 | 991992 | 992687 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.08 | 100.29 | WP_011681175 |
| KGMDKBNI_1 | 619528 | 620831 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.17 | 99.54 | WP_000022832 |
| KGMDKBNI_1 | 1653666 | 1654676 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.44 | 99.41 | WP_002986042 |
| KGMDKBNI_1 | 152333 | 153616 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| KGMDKBNI_1 | 1116586 | 1117632 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| KGMDKBNI_1 | 1158306 | 1159289 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| KGMDKBNI_1 | 725641 | 726714 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| KGMDKBNI_1 | 535843 | 536811 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| KGMDKBNI_1 | 1530452 | 1532755 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| KGMDKBNI_1 | 1253120 | 1254601 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| KGMDKBNI_1 | 747582 | 749828 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| KGMDKBNI_1 | 72303 | 73301 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| KGMDKBNI_1 | 27208 | 28179 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| KGMDKBNI_1 | 1415485 | 1414334 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| KGMDKBNI_1 | 1379155 | 1377167 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| KGMDKBNI_1 | 1142098 | 1140368 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| KGMDKBNI_1 | 1874662 | 1873184 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| KGMDKBNI_1 | 619528 | 620829 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| KGMDKBNI_1 | 1859473 | 1857581 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| KGMDKBNI_1 | 752753 | 751044 | PGM | 0.0 | phosphoglucomutase | 83.71 | 99.65 | ACH87041 |
| KGMDKBNI_1 | 1698150 | 1699160 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| KGMDKBNI_1 | 906668 | 905307 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| KGMDKBNI_1 | 1750192 | 1748300 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| KGMDKBNI_1 | 605093 | 605983 | bglB | 1.35e-178 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| KGMDKBNI_1 | 813822 | 812884 | SP_0676 | 2.40e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| KGMDKBNI_1 | 750020 | 750877 | metF | 1.56e-164 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| KGMDKBNI_1 | 1031689 | 1030985 | covR | 4.46e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| KGMDKBNI_1 | 1211928 | 1211257 | rr01 | 3.06e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| KGMDKBNI_1 | 1031689 | 1030985 | walR | 1.88e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| KGMDKBNI_1 | 310371 | 311057 | CovR | 1.02e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| KGMDKBNI_1 | 756707 | 757375 | CiaR | 2.06e-117 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| KGMDKBNI_1 | 756707 | 757378 | ciaR | 2.02e-115 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| KGMDKBNI_1 | 73577 | 73951 | SpxA2 | 1.17e-69 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| KGMDKBNI_1 | 918028 | 918429 | SpxA1 | 4.88e-66 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| KGMDKBNI_1 | 153774 | 154274 | RopE (M5005_Spy_1611) | 5.01e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| KGMDKBNI_1 | 1530452 | 1532749 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| KGMDKBNI_1 | 1735720 | 1734701 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| KGMDKBNI_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)