Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 28 | 37.54 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| HGIAEJHP_1 | 1137529 | 1138398 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| HGIAEJHP_1 | 1136936 | 1137529 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| HGIAEJHP_1 | 1136936 | 1137529 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| HGIAEJHP_1 | 1351548 | 1352504 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| HGIAEJHP_1 | 1350755 | 1351564 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.75 | 100.00 | WP_002948020 |
| HGIAEJHP_1 | 1352501 | 1353649 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| HGIAEJHP_1 | 1136936 | 1137529 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| HGIAEJHP_1 | 1349550 | 1350755 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226326 |
| HGIAEJHP_1 | 1346694 | 1348478 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.55 | 100.00 | WP_011226325 |
| HGIAEJHP_1 | 1357145 | 1357996 | rfbD | 0.0 | Capsule | Immune modulation | 99.53 | 100.00 | WP_014621820 |
| HGIAEJHP_1 | 43686 | 44525 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| HGIAEJHP_1 | 1353758 | 1354768 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226330 |
| HGIAEJHP_1 | 1348475 | 1349530 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.43 | 100.00 | WP_002948022 |
| HGIAEJHP_1 | 901766 | 903424 | fbp54 | 0.0 | FBPs | Adherence | 99.34 | 100.00 | WP_011227179 |
| HGIAEJHP_1 | 1013981 | 1014712 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.04 | 100.00 | WP_011681176 |
| HGIAEJHP_1 | 1013981 | 1014712 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011226048 |
| HGIAEJHP_1 | 1013981 | 1014712 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.63 | 100.00 | WP_011227248 |
| HGIAEJHP_1 | 1080719 | 1081507 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 99.75 | - |
| HGIAEJHP_1 | 1004040 | 1005455 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 97.81 | 100.00 | WP_011681165 |
| HGIAEJHP_1 | 1173721 | 1174482 | srtA | 0.0 | Sortase A | Exoenzyme | 97.64 | 100.00 | - |
| HGIAEJHP_1 | 1354771 | 1356042 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| HGIAEJHP_1 | 1014713 | 1016173 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.47 | 100.00 | WP_011681177 |
| HGIAEJHP_1 | 1014713 | 1016173 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.85 | 100.21 | WP_011226049 |
| HGIAEJHP_1 | 1014713 | 1016173 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.89 | 100.21 | WP_041827043 |
| HGIAEJHP_1 | 1013280 | 1013972 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 95.40 | 99.86 | WP_011227247 |
| HGIAEJHP_1 | 1013280 | 1013972 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 95.40 | 99.86 | WP_011226047 |
| HGIAEJHP_1 | 1011090 | 1012455 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.17 | 99.85 | WP_011681173 |
| HGIAEJHP_1 | 1012512 | 1013270 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 93.94 | 100.94 | WP_011681174 |
| HGIAEJHP_1 | 1011088 | 1012455 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 93.93 | 100.00 | WP_011226045 |
| HGIAEJHP_1 | 1012512 | 1013270 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 93.81 | 100.94 | WP_011226046 |
| HGIAEJHP_1 | 1012517 | 1013270 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 93.24 | 99.07 | WP_011227246 |
| HGIAEJHP_1 | 1013280 | 1013972 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.47 | 100.00 | WP_011681175 |
| HGIAEJHP_1 | 638397 | 639700 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| HGIAEJHP_1 | 1645974 | 1646984 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.45 | 99.90 | WP_002986042 |
| HGIAEJHP_1 | 1135461 | 1136507 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| HGIAEJHP_1 | 160759 | 162042 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.58 | 99.77 | WP_000107753 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| HGIAEJHP_1 | 1177169 | 1178152 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| HGIAEJHP_1 | 742113 | 743186 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| HGIAEJHP_1 | 554999 | 555967 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| HGIAEJHP_1 | 1522965 | 1525268 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| HGIAEJHP_1 | 1251765 | 1253246 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| HGIAEJHP_1 | 778556 | 780802 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| HGIAEJHP_1 | 65876 | 66868 | recA | 0.0 | DNA recombination and repair | 91.24 | 85.31 | AAL00560 |
| HGIAEJHP_1 | 27202 | 28173 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| HGIAEJHP_1 | 1409180 | 1408029 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| HGIAEJHP_1 | 1373288 | 1371300 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| HGIAEJHP_1 | 1160973 | 1159243 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| HGIAEJHP_1 | 1853973 | 1852495 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| HGIAEJHP_1 | 638397 | 639698 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| HGIAEJHP_1 | 1838783 | 1836894 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.89 | 98.75 | ABP91129 |
| HGIAEJHP_1 | 783727 | 782018 | PGM | 0.0 | phosphoglucomutase | 83.89 | 99.65 | ACH87041 |
| HGIAEJHP_1 | 1689654 | 1690664 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| HGIAEJHP_1 | 927726 | 926365 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| HGIAEJHP_1 | 1741348 | 1739456 | PepO | 0.0 | endopeptidase | 80.03 | 100.00 | ABF32980 |
| HGIAEJHP_1 | 623962 | 624852 | bglB | 5.33e-177 | putative phospho--glucosidase | 88.22 | 99.66 | AAK33487 |
| HGIAEJHP_1 | 843091 | 842153 | SP_0676 | 2.37e-167 | transcription facot | 81.15 | 97.20 | AAK74821 |
| HGIAEJHP_1 | 780994 | 781851 | metF | 8.70e-165 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| HGIAEJHP_1 | 1052881 | 1052177 | covR | 4.41e-131 | responder protein | 85.53 | 100.00 | AAK71319 |
| HGIAEJHP_1 | 1232789 | 1232118 | rr01 | 3.02e-124 | response regulator | 83.93 | 99.56 | CAB54566 |
| HGIAEJHP_1 | 1052881 | 1052177 | walR | 1.86e-121 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| HGIAEJHP_1 | 787681 | 788349 | CiaR | 9.47e-118 | two-component response regulator | 84.75 | 99.55 | AAK74935 |
| HGIAEJHP_1 | 315152 | 315838 | CovR | 1.01e-117 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| HGIAEJHP_1 | 787681 | 788352 | ciaR | 1.03e-115 | two component system response regulator | 82.59 | 99.12 | AIK75708 |
| HGIAEJHP_1 | 67180 | 67575 | SpxA2 | 3.20e-73 | transcriptional regulator | 90.15 | 100.00 | ERL21461 |
| HGIAEJHP_1 | 162200 | 162700 | RopE (M5005_Spy_1611) | 4.95e-75 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| HGIAEJHP_1 | 1522965 | 1525262 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| HGIAEJHP_1 | 1726939 | 1725920 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 95.88 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| HGIAEJHP_1 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)