Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 21 | 33 | 39.12 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| CCKBHMOF_16 | 53592 | 54461 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| CCKBHMOF_16 | 52999 | 53592 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| CCKBHMOF_21 | 27897 | 28865 | STER_RS07090 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681443 |
| CCKBHMOF_16 | 52999 | 53592 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| CCKBHMOF_16 | 52999 | 53592 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| CCKBHMOF_9 | 13075 | 14733 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| CCKBHMOF_1 | 21034 | 21873 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.41 | 100.00 | WP_011226733 |
| CCKBHMOF_21 | 28883 | 29860 | STER_RS07095 | 0.0 | Capsule | Immune modulation | 99.39 | 100.00 | WP_011681444 |
| CCKBHMOF_16 | 88361 | 89122 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| CCKBHMOF_13 | 7442 | 8182 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011226046 |
| CCKBHMOF_14 | 25 | 1479 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.49 | 100.00 | WP_041827043 |
| CCKBHMOF_13 | 7442 | 8182 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011681174 |
| CCKBHMOF_15 | 19938 | 20731 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 100.25 | - |
| CCKBHMOF_21 | 27180 | 27896 | STER_RS07085 | 0.0 | Capsule | Immune modulation | 98.19 | 100.00 | WP_011681442 |
| CCKBHMOF_13 | 8192 | 8884 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011227247 |
| CCKBHMOF_13 | 8192 | 8884 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_011226047 |
| CCKBHMOF_14 | 25 | 1479 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 97.94 | 100.00 | WP_011226049 |
| CCKBHMOF_13 | 7447 | 8182 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 97.83 | 98.13 | WP_011227246 |
| CCKBHMOF_21 | 31234 | 32085 | rfbD | 0.0 | Capsule | Immune modulation | 97.07 | 100.00 | WP_014621820 |
| CCKBHMOF_14 | 25 | 1479 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 96.92 | 99.79 | WP_011681177 |
| CCKBHMOF_21 | 26064 | 26834 | STER_RS07075 | 0.0 | Capsule | Immune modulation | 96.89 | 99.10 | WP_011681440 |
| CCKBHMOF_21 | 29857 | 31115 | STER_RS07100 | 0.0 | Capsule | Immune modulation | 96.51 | 99.92 | WP_011681445 |
| CCKBHMOF_13 | 6018 | 7385 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 96.42 | 100.00 | WP_011226045 |
| CCKBHMOF_13 | 6020 | 7385 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 94.14 | 99.85 | WP_011681173 |
| CCKBHMOF_13 | 8192 | 8884 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011681175 |
| CCKBHMOF_2 | 95763 | 97066 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| CCKBHMOF_25 | 564 | 1574 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.46 | 99.80 | WP_002986042 |
| CCKBHMOF_34 | 6130 | 7413 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| CCKBHMOF_16 | 51524 | 52570 | rfbB | 0.0 | Capsule | Immune modulation | 80.52 | 100.00 | WP_009659423 |
| CCKBHMOF_11 | 66738 | 67321 | SPD_RS01775 | 1.90e-151 | Capsule | Immune modulation | 83.42 | 96.20 | WP_001819836 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| CCKBHMOF_16 | 91809 | 92792 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| CCKBHMOF_3 | 86443 | 87516 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| CCKBHMOF_2 | 12126 | 13094 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| CCKBHMOF_22 | 2317 | 4620 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| CCKBHMOF_16 | 162126 | 163607 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| CCKBHMOF_14 | 57919 | 55673 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| CCKBHMOF_12 | 12635 | 13633 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| CCKBHMOF_1 | 4551 | 5522 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| CCKBHMOF_21 | 73121 | 71970 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.06 | 99.74 | AAL00050 |
| CCKBHMOF_21 | 45124 | 43136 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| CCKBHMOF_16 | 75613 | 73883 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| CCKBHMOF_29 | 71731 | 70253 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.42 | 100.00 | ADE32434 |
| CCKBHMOF_2 | 95763 | 97064 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| CCKBHMOF_29 | 56542 | 54650 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| CCKBHMOF_8 | 47718 | 46009 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| CCKBHMOF_27 | 21661 | 22671 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| CCKBHMOF_11 | 1520 | 159 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| CCKBHMOF_28 | 48722 | 46830 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| CCKBHMOF_2 | 81328 | 82218 | bglB | 8.52e-180 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| CCKBHMOF_8 | 5070 | 4135 | SP_0676 | 2.12e-169 | transcription facot | 81.73 | 96.89 | AAK74821 |
| CCKBHMOF_14 | 55481 | 54624 | metF | 5.96e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| CCKBHMOF_14 | 38301 | 37597 | covR | 1.71e-132 | responder protein | 85.53 | 100.00 | AAK71319 |
| CCKBHMOF_16 | 143149 | 142478 | rr01 | 2.84e-125 | response regulator | 83.93 | 99.56 | CAB54566 |
| CCKBHMOF_14 | 38301 | 37597 | walR | 7.20e-123 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| CCKBHMOF_23 | 4172 | 4858 | CovR | 3.50e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| CCKBHMOF_8 | 51672 | 52340 | CiaR | 5.83e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| CCKBHMOF_8 | 51672 | 52343 | ciaR | 5.74e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| CCKBHMOF_12 | 13909 | 14283 | SpxA2 | 9.03e-72 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| CCKBHMOF_11 | 12879 | 13280 | SpxA1 | 1.40e-67 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| CCKBHMOF_36 | 14124 | 14411 | spr0479 | 3.03e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| CCKBHMOF_37 | 119438 | 119692 | spr1327 | 1.30e-44 | essential gene | 94.12 | 100.00 | AAL00131 |
| CCKBHMOF_29 | 13952 | 14215 | spr0175 | 3.80e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| CCKBHMOF_29 | 14779 | 15045 | spr0177 | 8.32e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| CCKBHMOF_34 | 7571 | 8071 | RopE (M5005_Spy_1611) | 2.27e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| CCKBHMOF_22 | 2317 | 4614 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| CCKBHMOF_28 | 34261 | 33242 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| CCKBHMOF_1 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_2 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_3 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_4 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_5 | 1.0 | 0.0 | 1.0 |
| CCKBHMOF_6 | 1.0 | 0.0 | 1.0 |
| CCKBHMOF_7 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_8 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_9 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_10 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_11 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_12 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_13 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_14 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_15 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_16 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_17 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_18 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_19 | 1.0 | 0.0 | 1.0 |
| CCKBHMOF_20 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_21 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_22 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_23 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_24 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_25 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_26 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_27 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_28 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_29 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_31 | 1.0 | 0.0 | 1.0 |
| CCKBHMOF_32 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_33 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_34 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_35 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_36 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_37 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_38 | 0.0 | 1.0 | 0.0 |
| CCKBHMOF_39 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)