Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 25 | 32 | 40.61 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| FDPFDMPP_39 | 131892 | 132761 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| FDPFDMPP_39 | 132761 | 133354 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| FDPFDMPP_18 | 297389 | 298195 | STER_RS07060 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681437 |
| FDPFDMPP_39 | 132761 | 133354 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| FDPFDMPP_42 | 13640 | 14371 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 99.73 | 100.00 | WP_011681176 |
| FDPFDMPP_18 | 301159 | 302904 | STR_RS06885 | 0.0 | Capsule | Immune modulation | 99.71 | 100.00 | WP_011227426 |
| FDPFDMPP_18 | 296448 | 297389 | STR_RS06905 | 0.0 | Capsule | Immune modulation | 99.68 | 100.00 | WP_011227430 |
| FDPFDMPP_39 | 132761 | 133354 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| FDPFDMPP_33 | 2565 | 3708 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 99.65 | 100.00 | - |
| FDPFDMPP_18 | 299415 | 301055 | STER_RS07050 | 0.0 | Capsule | Immune modulation | 99.63 | 96.47 | WP_041827753 |
| FDPFDMPP_2 | 50351 | 52009 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| FDPFDMPP_18 | 296448 | 297389 | STER_RS07065 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011681438 |
| FDPFDMPP_21 | 21857 | 22696 | cbpD | 0.0 | Autolysin | Exoenzyme | 99.52 | 100.00 | WP_011226733 |
| FDPFDMPP_18 | 298195 | 299397 | STER_RS07055 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011681436 |
| FDPFDMPP_18 | 297389 | 298195 | STR_RS06900 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011227429 |
| FDPFDMPP_18 | 299415 | 301055 | STR_RS06890 | 0.0 | Capsule | Immune modulation | 99.45 | 96.47 | WP_041827077 |
| FDPFDMPP_18 | 298195 | 299397 | STR_RS06895 | 0.0 | Capsule | Immune modulation | 99.42 | 100.00 | WP_011227428 |
| FDPFDMPP_18 | 291368 | 292642 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 98.98 | 100.00 | WP_011226331 |
| FDPFDMPP_18 | 292642 | 293604 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 98.86 | 95.25 | WP_011226330 |
| FDPFDMPP_42 | 12189 | 12929 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.52 | 100.00 | WP_011681174 |
| FDPFDMPP_42 | 12189 | 12929 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.38 | 100.00 | WP_011226046 |
| FDPFDMPP_18 | 301159 | 302904 | STER_RS07045 | 0.0 | Capsule | Immune modulation | 98.17 | 100.00 | WP_011681434 |
| FDPFDMPP_18 | 289414 | 290265 | rfbD | 0.0 | Capsule | Immune modulation | 98.12 | 100.00 | WP_014621820 |
| FDPFDMPP_42 | 12194 | 12929 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 98.10 | 98.13 | WP_011227246 |
| FDPFDMPP_42 | 13640 | 14371 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 97.95 | 100.00 | WP_011227248 |
| FDPFDMPP_42 | 13640 | 14371 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 97.81 | 100.00 | WP_011226048 |
| FDPFDMPP_39 | 97232 | 97993 | srtA | 0.0 | Sortase A | Exoenzyme | 97.77 | 100.00 | - |
| FDPFDMPP_42 | 14372 | 15832 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 97.67 | 100.00 | WP_011681177 |
| FDPFDMPP_42 | 14372 | 15832 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 96.51 | 100.21 | WP_011226049 |
| FDPFDMPP_42 | 14372 | 15832 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 95.69 | 100.21 | WP_041827043 |
| FDPFDMPP_42 | 10768 | 12133 | STER_RS05300 | 0.0 | Capsule | Immune modulation | 95.39 | 99.85 | WP_011681173 |
| FDPFDMPP_42 | 10766 | 12133 | STU_RS14630 | 0.0 | Capsule | Immune modulation | 94.37 | 100.00 | WP_011226045 |
| FDPFDMPP_18 | 295306 | 296451 | STR_RS06910 | 0.0 | Capsule | Immune modulation | 93.02 | 99.74 | WP_011227431 |
| FDPFDMPP_18 | 295306 | 296451 | STER_RS07070 | 0.0 | Capsule | Immune modulation | 92.76 | 99.74 | WP_011681439 |
| FDPFDMPP_42 | 12939 | 13631 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 92.50 | 100.00 | WP_011681175 |
| FDPFDMPP_29 | 78984 | 80287 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| FDPFDMPP_42 | 12939 | 13631 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 87.88 | 100.00 | WP_011226047 |
| FDPFDMPP_42 | 12939 | 13631 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 87.59 | 100.00 | WP_011227247 |
| FDPFDMPP_24 | 51 | 1061 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 87.46 | 99.80 | WP_002986042 |
| FDPFDMPP_18 | 297389 | 298195 | SGO_RS05020 | 0.0 | Capsule | Immune modulation | 82.90 | 100.00 | WP_012000440 |
| FDPFDMPP_55 | 6252 | 7535 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| FDPFDMPP_39 | 133783 | 134829 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
| FDPFDMPP_42 | 1235 | 1818 | SPD_RS01775 | 8.02e-148 | Capsule | Immune modulation | 83.11 | 96.04 | WP_001819836 |
| FDPFDMPP_18 | 298195 | 298932 | SGO_RS05025 | 0.0 | Capsule | Immune modulation | 84.96 | 60.29 | WP_012000441 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| FDPFDMPP_12 | 27641 | 28714 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| FDPFDMPP_39 | 94545 | 93562 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.21 | 100.00 | AAK75326 |
| FDPFDMPP_18 | 119158 | 116855 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| FDPFDMPP_29 | 162531 | 161563 | spr0084 | 0.0 | pathogenitcity related | 92.88 | 98.48 | AAK98888 |
| FDPFDMPP_39 | 14328 | 12847 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.71 | 100.00 | ABJ54480 |
| FDPFDMPP_23 | 5571 | 7817 | metE | 0.0 | methionine biosynthesis enzymes | 91.99 | 100.00 | AAK74738 |
| FDPFDMPP_21 | 1845 | 847 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| FDPFDMPP_22 | 4234 | 5205 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| FDPFDMPP_18 | 240279 | 241430 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| FDPFDMPP_18 | 276238 | 278226 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.84 | 100.00 | AE014259_2 |
| FDPFDMPP_39 | 110744 | 112474 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| FDPFDMPP_47 | 26950 | 28428 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.63 | 100.00 | ADE32434 |
| FDPFDMPP_29 | 80287 | 78986 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| FDPFDMPP_47 | 41688 | 43580 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 85.74 | 98.90 | ABP91129 |
| FDPFDMPP_23 | 10742 | 9033 | PGM | 0.0 | phosphoglucomutase | 84.06 | 99.65 | ACH87041 |
| FDPFDMPP_50 | 54828 | 53818 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| FDPFDMPP_2 | 25374 | 26735 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| FDPFDMPP_50 | 4493 | 6385 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| FDPFDMPP_29 | 94722 | 93832 | bglB | 4.94e-179 | putative phospho--glucosidase | 88.55 | 99.66 | AAK33487 |
| FDPFDMPP_7 | 39571 | 40506 | SP_0676 | 2.01e-169 | transcription facot | 81.73 | 96.89 | AAK74821 |
| FDPFDMPP_23 | 8009 | 8866 | metF | 1.35e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| FDPFDMPP_42 | 52626 | 51922 | covR | 3.20e-132 | responder protein | 85.53 | 100.00 | AAK71319 |
| FDPFDMPP_39 | 42432 | 43103 | rr01 | 2.30e-125 | response regulator | 83.93 | 99.56 | CAB54566 |
| FDPFDMPP_42 | 52626 | 51922 | walR | 1.35e-122 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| FDPFDMPP_20 | 16033 | 16719 | CovR | 1.50e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| FDPFDMPP_23 | 14696 | 15364 | CiaR | 1.80e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| FDPFDMPP_23 | 14696 | 15367 | ciaR | 1.77e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| FDPFDMPP_21 | 571 | 197 | SpxA2 | 1.41e-71 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| FDPFDMPP_15 | 25564 | 25277 | spr0479 | 2.99e-49 | essential gene | 86.46 | 98.97 | AAK99283 |
| FDPFDMPP_46 | 22742 | 22488 | spr1327 | 1.07e-44 | essential gene | 94.12 | 100.00 | AAL00131 |
| FDPFDMPP_47 | 86278 | 86015 | spr0175 | 3.85e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| FDPFDMPP_47 | 85451 | 85185 | spr0177 | 8.43e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| FDPFDMPP_55 | 7693 | 8193 | RopE (M5005_Spy_1611) | 1.79e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| FDPFDMPP_18 | 119158 | 116861 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| FDPFDMPP_50 | 18948 | 19967 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| FDPFDMPP_2 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_3 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_5 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_7 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_9 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_10 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_12 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_15 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_16 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_17 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_18 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_19 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_20 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_21 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_22 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_23 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_24 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_25 | 1.0 | 0.0 | 1.0 |
| FDPFDMPP_26 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_27 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_28 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_29 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_30 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_31 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_32 | 1.0 | 0.0 | 1.0 |
| FDPFDMPP_33 | 1.0 | 0.0 | 1.0 |
| FDPFDMPP_34 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_35 | 1.0 | 0.0 | 1.0 |
| FDPFDMPP_36 | 1.0 | 0.0 | 1.0 |
| FDPFDMPP_37 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_39 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_42 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_46 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_47 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_50 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_53 | 0.0 | 1.0 | 0.0 |
| FDPFDMPP_55 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| FDPFDMPP_5 | 5692 | 16088 | True | Siphoviridae | VOG9404, VOG5532, VOG0944, VOG0058, VOG0275, VOG9403, VOG9667, VOG4602, VOG4603 |
Phigaro v2.4.0 (Database: Jan. 2024 release)