Probiotic potential risk score
| ARGs | VFs | PGs | PPRS |
|---|---|---|---|
| 0 | 27 | 35 | 44.20 |
PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).
Antibiotic resistance genes
Comprehensive Antibiotic Resistance Database (CARD)
| Query ID | Begin | End | ARO name | ARO accession | CARD name | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
RGI v6.0.3 (Database: CARD Variants v4.0.2, Nov. 2023 release)
ResFinder
| Query ID | Begin | End | Resistance gene | Phenotype | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|
| No hit found | |||||||
ResFinder v4.6.0 (Database: resfinder_db, Aug. 2024 release)
AMRFinderPlus
| Query ID | Begin | End | Gene symbol | Sequence name | Method | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
AMRFinderPlus v4.0.3 (Database: Oct. 2024 release)
Virulence factors
Virulence Factor Database (VFDB)
| Query ID | qstart | qend | Gene name | e-value | VF name | VF category | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|---|
| PDEGELGB_54 | 19478 | 20347 | rfbA | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011681286 |
| PDEGELGB_54 | 20347 | 20940 | STER_RS06030 | 0.0 | Capsule | Immune modulation | 100.00 | 100.00 | WP_011226149 |
| PDEGELGB_82 | 6423 | 7232 | STU_RS16245 | 0.0 | Capsule | Immune modulation | 99.88 | 100.00 | WP_002948020 |
| PDEGELGB_54 | 20347 | 20940 | STR_RS05880 | 0.0 | Capsule | Immune modulation | 99.83 | 100.00 | WP_011226149 |
| PDEGELGB_82 | 7216 | 8172 | STU_RS16250 | 0.0 | Capsule | Immune modulation | 99.79 | 100.00 | WP_011226328 |
| PDEGELGB_82 | 8169 | 9317 | STU_RS16255 | 0.0 | Capsule | Immune modulation | 99.74 | 100.00 | WP_041828290 |
| PDEGELGB_54 | 20347 | 20940 | STU_RS15260 | 0.0 | Capsule | Immune modulation | 99.66 | 100.00 | WP_011226149 |
| PDEGELGB_82 | 12813 | 13664 | rfbD | 0.0 | Capsule | Immune modulation | 99.65 | 100.00 | WP_014621820 |
| PDEGELGB_102 | 13157 | 14815 | fbp54 | 0.0 | FBPs | Adherence | 99.58 | 100.00 | WP_011227179 |
| PDEGELGB_82 | 5218 | 6423 | STU_RS16240 | 0.0 | Capsule | Immune modulation | 99.58 | 100.00 | WP_011226326 |
| PDEGELGB_82 | 9426 | 10436 | STU_RS16260 | 0.0 | Capsule | Immune modulation | 99.50 | 100.00 | WP_011226330 |
| PDEGELGB_30 | 95 | 651 | STR_RS05245 | 0.0 | Capsule | Immune modulation | 99.46 | 92.83 | WP_196767671 |
| PDEGELGB_82 | 2362 | 4146 | STU_RS16230 | 0.0 | Capsule | Immune modulation | 99.44 | 100.00 | WP_011226325 |
| PDEGELGB_82 | 4143 | 5198 | STU_RS16235 | 0.0 | Capsule | Immune modulation | 99.43 | 100.00 | WP_002948022 |
| PDEGELGB_109 | 595 | 2010 | STER_RS05250 | 0.0 | Capsule | Immune modulation | 99.15 | 100.00 | WP_011681165 |
| PDEGELGB_30 | 803 | 1538 | STER_RS05305 | 0.0 | Capsule | Immune modulation | 98.91 | 99.33 | WP_011681174 |
| PDEGELGB_20 | 14455 | 15423 | cbpD | 0.0 | Autolysin | Exoenzyme | 98.86 | 100.00 | WP_082302295 |
| PDEGELGB_53 | 13834 | 14595 | srtA | 0.0 | Sortase A | Exoenzyme | 98.82 | 100.00 | - |
| PDEGELGB_30 | 2249 | 2980 | STER_RS05315 | 0.0 | Capsule | Immune modulation | 98.77 | 100.00 | WP_011681176 |
| PDEGELGB_30 | 2981 | 4435 | STR_RS05265 | 0.0 | Capsule | Immune modulation | 98.76 | 100.00 | WP_041827043 |
| PDEGELGB_92 | 312 | 1271 | STR_RS05240 | 0.0 | Capsule | Immune modulation | 98.54 | 100.00 | WP_041827042 |
| PDEGELGB_30 | 2249 | 2980 | STU_RS14645 | 0.0 | Capsule | Immune modulation | 98.50 | 100.00 | WP_011226048 |
| PDEGELGB_64 | 818 | 1611 | cshA | 0.0 | Cell surface hydrophobicity proteins | Adherence | 98.36 | 100.25 | - |
| PDEGELGB_30 | 2249 | 2980 | STR_RS05260 | 0.0 | Capsule | Immune modulation | 98.36 | 100.00 | WP_011227248 |
| PDEGELGB_30 | 789 | 1538 | STR_RS05250 | 0.0 | Capsule | Immune modulation | 98.27 | 100.00 | WP_011227246 |
| PDEGELGB_30 | 2981 | 4435 | STU_RS14650 | 0.0 | Capsule | Immune modulation | 98.21 | 100.00 | WP_011226049 |
| PDEGELGB_30 | 803 | 1538 | STU_RS14635 | 0.0 | Capsule | Immune modulation | 98.10 | 99.33 | WP_011226046 |
| PDEGELGB_82 | 10439 | 11710 | STU_RS16265 | 0.0 | Capsule | Immune modulation | 97.48 | 99.76 | WP_011226331 |
| PDEGELGB_30 | 2981 | 4435 | STER_RS05320 | 0.0 | Capsule | Immune modulation | 96.65 | 99.79 | WP_011681177 |
| PDEGELGB_89 | 33282 | 38176 | SAG_RS09105 | 0.0 | Agglutinin receptor | Adherence | 92.87 | 99.98 | WP_000167699 |
| PDEGELGB_89 | 33282 | 38224 | SSU98_0978 | 0.0 | Agglutinin receptor | Adherence | 92.82 | 99.78 | YP_001200536 |
| PDEGELGB_89 | 33282 | 38224 | SSU05_0965 | 0.0 | Agglutinin receptor | Adherence | 92.80 | 99.78 | YP_001198331 |
| PDEGELGB_30 | 1548 | 2240 | STER_RS05310 | 0.0 | Capsule | Immune modulation | 89.90 | 100.00 | WP_011681175 |
| PDEGELGB_30 | 1548 | 2240 | STU_RS14640 | 0.0 | Capsule | Immune modulation | 89.75 | 100.00 | WP_011226047 |
| PDEGELGB_30 | 1548 | 2240 | STR_RS05255 | 0.0 | Capsule | Immune modulation | 89.47 | 100.00 | WP_011227247 |
| PDEGELGB_44 | 49411 | 50714 | eno | 0.0 | Streptococcal enolase | Exoenzyme | 88.10 | 99.46 | WP_000022832 |
| PDEGELGB_83 | 92 | 1102 | plr/gapA | 0.0 | Streptococcal plasmin receptor/GAPDH | Adherence | 86.54 | 99.41 | WP_002986042 |
| PDEGELGB_45 | 62891 | 64174 | tig/ropA | 0.0 | Trigger factor | Stress survival | 80.73 | 99.77 | WP_000107753 |
| PDEGELGB_54 | 21369 | 22415 | rfbB | 0.0 | Capsule | Immune modulation | 80.61 | 100.00 | WP_009659423 |
BLASTN v2.16.0 (Database: VFDB, Dec. 2024 release)
VirulenceFinder
| Query ID | Begin | End | Database | Virulence factor | Protein function | Identity | Coverage | Accession no. |
|---|---|---|---|---|---|---|---|---|
| No hit found | ||||||||
VirulenceFinder v2.0. 4 (Database: virulencefinder_db, Feb . 2024 release)
Pathogenic genes
PHI-base
| Query ID | qstart | qend | Gene name | e-value | Function | Identity | Coverage | Gene ID |
|---|---|---|---|---|---|---|---|---|
| PDEGELGB_53 | 11147 | 10164 | ldh(Sp_1220) | 0.0 | L-lactate dehydrogenase | 94.82 | 100.00 | AAK75326 |
| PDEGELGB_62 | 6711 | 7784 | MntE | 0.0 | manganese homeostasis | 94.41 | 99.72 | ABF32167 |
| PDEGELGB_89 | 38197 | 33287 | B9H01_RS04765 | 0.0 | glucan-binding protein | 93.40 | 99.63 | AUS90958 |
| PDEGELGB_44 | 134399 | 133431 | spr0084 | 0.0 | pathogenitcity related | 93.19 | 98.48 | AAK98888 |
| PDEGELGB_63 | 15570 | 13267 | pfl2(Sp_0459) | 0.0 | formate acetyltransferase | 92.97 | 99.22 | AAK74619 |
| PDEGELGB_78 | 13142 | 11661 | SPD_0310 | 0.0 | UPF0371 protein SPD_0310 | 92.31 | 100.00 | ABJ54480 |
| PDEGELGB_96 | 6146 | 8392 | metE | 0.0 | methionine biosynthesis enzymes | 91.72 | 100.00 | AAK74738 |
| PDEGELGB_84 | 1890 | 892 | recA | 0.0 | DNA recombination and repair | 91.29 | 85.82 | AAL00560 |
| PDEGELGB_52 | 15407 | 14436 | prsA2 | 0.0 | ribose-phosphate pyrophosphokinase | 90.12 | 100.00 | ABF36968 |
| PDEGELGB_42 | 19995 | 18844 | potA | 0.0 | ABC transporter ATP-binding protein-spermidine/putrescine transport | 89.32 | 99.74 | AAL00050 |
| PDEGELGB_82 | 28634 | 26646 | uvrB | 0.0 | excinuclease ABC, B subunit | 88.99 | 100.00 | AE014259_2 |
| PDEGELGB_53 | 27346 | 29076 | ptsI | 0.0 | phosphoenolpyruvate-protein phosphotransferase | 88.04 | 100.00 | AAK34199 |
| PDEGELGB_40 | 26994 | 28472 | IMPDH | 0.0 | inosine-5'-monophosphate dehydrogenase | 87.22 | 100.00 | ADE32434 |
| PDEGELGB_44 | 50714 | 49413 | Eno | 0.0 | enolase | 86.21 | 99.77 | ABP90468 |
| PDEGELGB_40 | 42183 | 44075 | gidA | 0.0 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | 86.05 | 98.90 | ABP91129 |
| PDEGELGB_96 | 11317 | 9608 | PGM | 0.0 | phosphoglucomutase | 83.71 | 99.65 | ACH87041 |
| PDEGELGB_47 | 2072 | 1062 | pdh | 0.0 | pyruvate dehydrogenase | 83.09 | 99.70 | ABP91006 |
| PDEGELGB_58 | 30234 | 31595 | mnmE | 0.0 | central tRNA-modifying GTPase | 82.24 | 99.56 | ABP90420 |
| PDEGELGB_98 | 59884 | 57992 | PepO | 0.0 | endopeptidase | 80.19 | 100.00 | ABF32980 |
| PDEGELGB_44 | 65149 | 64259 | bglB | 1.06e-179 | putative phospho--glucosidase | 88.89 | 99.66 | AAK33487 |
| PDEGELGB_61 | 3945 | 3007 | SP_0676 | 5.99e-169 | transcription facot | 81.15 | 97.20 | AAK74821 |
| PDEGELGB_96 | 8584 | 9441 | metF | 1.40e-166 | methionine biosynthesis enzymes | 86.36 | 99.31 | AAK74739 |
| PDEGELGB_64 | 29292 | 29996 | covR | 1.26e-132 | responder protein | 85.53 | 100.00 | AAK71319 |
| PDEGELGB_49 | 19727 | 19056 | rr01 | 6.85e-126 | response regulator | 83.93 | 99.56 | CAB54566 |
| PDEGELGB_64 | 29292 | 29996 | walR | 5.31e-123 | DNA-binding response regulator | 82.13 | 100.00 | ANC99504 |
| PDEGELGB_57 | 7744 | 7058 | CovR | 1.31e-119 | serves to repress GAS virulence factor-encoding genes | 80.79 | 100.00 | ACE75886 |
| PDEGELGB_96 | 15271 | 15939 | CiaR | 1.86e-119 | two-component response regulator | 84.31 | 99.55 | AAK74935 |
| PDEGELGB_96 | 15271 | 15942 | ciaR | 1.83e-117 | two component system response regulator | 82.14 | 99.12 | AIK75708 |
| PDEGELGB_84 | 616 | 242 | SpxA2 | 8.91e-72 | transcriptional regulator | 91.20 | 94.70 | ERL21461 |
| PDEGELGB_58 | 18875 | 18474 | SpxA1 | 1.10e-67 | transcriptional regulator | 80.60 | 100.00 | ERL19273 |
| PDEGELGB_66 | 25497 | 25210 | spr0479 | 1.31e-48 | essential gene | 85.42 | 98.97 | AAK99283 |
| PDEGELGB_20 | 56313 | 56567 | spr1327 | 1.11e-45 | essential gene | 95.29 | 100.00 | AAL00131 |
| PDEGELGB_40 | 86735 | 86472 | spr0175 | 4.62e-42 | pathogenitcity related | 84.09 | 100.00 | AAK98979 |
| PDEGELGB_40 | 85908 | 85642 | spr0177 | 8.16e-34 | essential gene | 84.27 | 88.12 | AAK98981 |
| PDEGELGB_45 | 62733 | 62233 | RopE (M5005_Spy_1611) | 1.82e-76 | probable DNA-directed RNA polymerase subunit delta | 81.44 | 87.43 | AAK34603 |
| PDEGELGB_63 | 15570 | 13273 | PFL (B9H01_RS01125) | 0.0 | formate C-acetyltransferase | 82.94 | 98.08 | MYN69560 |
| PDEGELGB_89 | 3573 | 2377 | AUS90997 (B9H01_RS07385) | 0.0 | site-specific integrase | 97.74 | 100.00 | AUS90997 |
| PDEGELGB_98 | 45412 | 44393 | ilvC (SPD_0406) | 0.0 | ketol-acid reductoisomerase (NADP(+)) | 96.47 | 100.00 | ABJ55451 |
BLASTX v2.16.0 (Database: PHI base v4.16, May. 2024 release)
Plasmid
PlasmidFinder
| Query ID | Begin | End | Plasmid | Query / Template | Identity | Accession no. |
|---|---|---|---|---|---|---|
| No hit found | ||||||
PlasmidFinder v 2.1.6 (Database: plasmidfinder_db v 2.2.0 , Nov. 2024 release)
PlasmidHunter
| Query ID | Prediction | Chromosome | Plasmid |
|---|---|---|---|
| PDEGELGB_2 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_5 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_6 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_8 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_9 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_11 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_13 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_20 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_30 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_36 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_38 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_39 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_40 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_41 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_42 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_43 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_44 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_45 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_47 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_49 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_50 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_51 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_52 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_53 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_54 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_55 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_57 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_58 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_60 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_61 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_62 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_63 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_64 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_66 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_67 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_68 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_69 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_70 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_71 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_72 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_73 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_74 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_76 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_78 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_80 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_81 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_82 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_83 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_84 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_85 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_86 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_87 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_89 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_90 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_91 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_92 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_93 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_94 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_96 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_97 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_98 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_99 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_100 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_101 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_102 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_104 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_109 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_111 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_113 | 0.0 | 1.0 | 0.0 |
| PDEGELGB_115 | 1.0 | 0.0 | 1.0 |
| PDEGELGB_117 | 0.0 | 1.0 | 0.0 |
PlasmidHunter v 1.4.5 (Database: May. 2024 release)
Prophage
Phigaro
| Query ID | Begin | End | Transposable | Taxonomy | pVOGs |
|---|---|---|---|---|---|
| No hit found | |||||
Phigaro v2.4.0 (Database: Jan. 2024 release)